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<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W389</accession>
    <name>F9W389_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_25680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000374">
        <property type="protein sequence ID" value="CCD11597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25680"/>
    <dbReference type="OrthoDB" id="1669917at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388616" evidence="10">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD11597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="42993" checksum="9186CA75A9346324" modified="2011-10-19" version="1">MELRSKWWWLAVGVFMTWSPVLGTGNTPKAIPTKAGAAICTLSKALKDVTPWATQKVKDGAAKITHLEMKLLEWQSKFIQPKSRGSGSEACKVTGLLFRQVRKEIDKTRKEVEKLEKEASKAAAFAANSAGRLDEFITVFVNARNESGDGFCIGKDKAATPEDLRGCFSGTDFGEESLVDISERASEQEPNLDSAIEGIKHSKLSSHFNGVSSTNTGCNLIKGASGGILGNTDLEKSLWWGGGILTIGKGFQGVFNNSLKAGEILAATKDTATWTKDPAKQIVHLMNASNAFNAFKAVQEKIQAKVKSIEEKIQTCLGGQETGENNTEQNATEQTGTTEQTPASPTCSDNVAKIAADLKEKRALLARYQKVKGWIPPSSAYNAKIPFIHFGFLLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3H8</accession>
    <name>F9W3H8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1054</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000412">
        <property type="protein sequence ID" value="CCD11696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26510"/>
    <dbReference type="OrthoDB" id="1693863at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="23362" checksum="F42506D347139EB1" modified="2011-10-19" version="1">MYPASCNTQSVHRGVAISPYSSWLARITQLFQHVIPAPHTAPHTKACAHTQHASKSFGNAILFTTILPQSHGHFAPPLVRKMEDTQSQGIINHEKRKPQLYFPCCVAYGTPQTPGDAASEIENRRSSCVGCAAFLKPLYTLRLVTAFDPHQNDFASFNCGFVGFLLITIRHAKETTPMLHGACYASQSSRTRTPAQLSAVCKACNCARCFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3V5</accession>
    <name>F9W3V5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000480">
        <property type="protein sequence ID" value="CCD11831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27740"/>
    <dbReference type="OrthoDB" id="895016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="246" mass="26173" checksum="5002AF31D3CB8F14" modified="2011-10-19" version="1">MHFSSRLEAICATAFPVTSAERIATVVNGFGVKRVRVWENDMEIQTPISASECDLLEGSRSFTSSINSSCDAADFSDTDSISNSEMSNVGWSTGTQSHAINESFSSPASHVRPLPAGSLSCSEEVVVGSGFGNSSPEVLFNNMTMSSSSNVDSPFTSVSSQCTCPTSGSSGTQMSSPKGETTTEKQTDWSSTPDNSNDKCRIAGEDGATTEGSGQLLQSLIVTTQQDLYVDFDAEYDDNDDINYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3V7</accession>
    <name>F9W3V7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_02980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000482">
        <property type="protein sequence ID" value="CCD11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02980"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389764" evidence="5">
        <location>
            <begin position="21"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="43"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="383" mass="42271" checksum="5D4FCD93BE31B5B6" modified="2011-10-19" version="1">MMLKLVFMIMVLTSMIGVSGSNEKEYEALCDVLRRAERVLNTTSTNGLLKRELTQAIYGRIDRALAIENGQVRVKGRCNDQTNRGQFCSYYTVSSRSYGCFAESLAGTILCTCTPGKNGHGKNFCGVNALKTSETWSGGGEEPAKKSILFQEVWDKVREKCFVGSDIVQSNTEELRNLEVAAKQFRDTLSPIRNSFFYISGSGADKCSGSNRNDVCTKYYGPKRNKNSVYIPWLTKILSALENIKNFPTQPAFQKDSAPTHTVAPTPEGPPAPVTSITVSPAESGPAEVREATTDESLHILRENTDSPSGEYEHLHPPQPTPDVASRNRRAITTNSDSVQNNKHKTTEAPIEKENTSNEFDFDHLISGSKIIKPILLLFAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W402</accession>
    <name>F9W402_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1132</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2119</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_16490</name>
        <name evidence="2" type="ORF">TCIL3000_0_28230</name>
        <name evidence="3" type="ORF">TCIL3000_0_52460</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000499">
        <property type="protein sequence ID" value="CCD11885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001596">
        <property type="protein sequence ID" value="CCD14647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002423">
        <property type="protein sequence ID" value="CCD16746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16490"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52460"/>
    <dbReference type="OrthoDB" id="1728724at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17188" checksum="E9F37F8CD7E1A3DF" modified="2011-10-19" version="1">MLKNNVLSVARYTKQLENKKHPTKKTQNTFANRCVANKNKRVNPLSKTNIKPSGKKNHGKKMQKDVMKRLNIKKIESNPITNRVNFKNNFIPSVIGVNKPNKNKAGPILSWVIANILRSHKLTYPHKTAKTSINIITIMYISKQKSILFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W455</accession>
    <name>F9W455_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_28760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000517">
        <property type="protein sequence ID" value="CCD11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28760"/>
    <dbReference type="OMA" id="CEASEAY"/>
    <dbReference type="OrthoDB" id="777540at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="153"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="5">
        <location>
            <begin position="622"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="941"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="966" mass="108407" checksum="132C596419DF91AD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4D0</accession>
    <name>F9W4D0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1170</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_29410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000542">
        <property type="protein sequence ID" value="CCD12020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29410"/>
    <dbReference type="OMA" id="EAYLGEF"/>
    <dbReference type="OrthoDB" id="1351067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="PTHR22629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="SSF69645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20640" checksum="AB74E90026EF66CA" modified="2011-10-19" version="1">MNDECQAYYTCVSRTLHAALCIGNYPSRAVERHNKPEVEVNDCTSDTGLGKSPEFLLNPIRITRSEHESCFIEPSINSVRVSFSFLKTEALADLISRKYVSFLAQRGQEFRILRKRPVSGYDISFLITHEDVETIPRGKIIQFMITFLMEIDEDIRNLKMNANERARRAASEIFKAMALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H7</accession>
    <name>F9W4H7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000556">
        <property type="protein sequence ID" value="CCD12069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29880"/>
    <dbReference type="OMA" id="ANDKRNC"/>
    <dbReference type="OrthoDB" id="1399249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="288" mass="31740" checksum="E772C069068D27EE" modified="2011-10-19" version="1">MKLHTPDSHDKIAWRRRYFFVAPPSHNVINRCKPTEVPHNLSVIVATNLSAVQAASFLRPIASLEKRSDNVGKSRSTFPLGSMKSTLDTAPIPPLFKVEVYVWNDTTLREILEEVLCSSPAAARVLLPPDASAADAVSSAASPDARGAVVDDKQSISEDSVMDGSKSSPDRMSGGEAPAKRSRLETKSESDSGELHGNDLSQSGSHRREGELRSPHDKPAKVYAFRVFIENEKPKIENIALLNTTRPIFHSGDYMTMKELRGTVRSPCKWKLGDLLVFTPTVQYYRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Q8</accession>
    <name>F9W4Q8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_15780</name>
        <name evidence="7" type="ORF">TCIL3000_0_30660</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000592">
        <property type="protein sequence ID" value="CCD12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002394">
        <property type="protein sequence ID" value="CCD16671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15780"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30660"/>
    <dbReference type="OrthoDB" id="1670703at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007659398" evidence="5">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="56"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38196" checksum="DE007EDF74873DA2" modified="2011-10-19" version="1">MKIQFLVFICAVVAVSGAEDGGAVVPRDHNKDEYHRLCNLMKAAVTKWGDGGQGLSEPLKKALGRTLFGNDKGGDLGQLKGVLPSDYNDVEDTPDSRGLWCGDPREGDYIGQNQARWSGHSAPHDMVCLCTAGEKGWPVNRSETSTEKDKLCGQDRTALKAESNQGWGYTRHTGNAHVDATWKATVTHCLDGDGKGEGLKVALGNFIEKLKPSPSRTYPSREQLGEGNATDSDACSGSSARGVCVMYYTNMKPTPWWKVLQEALIDDEKIQAEKRREEEEKRKQQEEERKTDESHEENITSSETTTQGTEKNRIETLHEAIRKYNTTSGTPISLPSSWLLSAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S3</accession>
    <name>F9W4S3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000597">
        <property type="protein sequence ID" value="CCD12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30770"/>
    <dbReference type="OMA" id="NWAGFFS"/>
    <dbReference type="OrthoDB" id="1302407at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="195" mass="23083" checksum="E857E2A89261EAB4" modified="2011-10-19" version="1">MLNLLSMPCLHRFSMYLYLCHPHRVVVRSTKQVKCPSKMIRRTAPAVSFTTSHRALMLRTNRPLLAADMHSTERFKAAWDEMPVHLLGASRKQSFEWYWKCMYQLGIRSTYRMTKGRVAMTWGALFVFLYLTYASVFYSSFYHIYYQDWPEEFKRENARAYAQSKGSDVWAADGKFIRPYFHINPPMLTMTTDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U1</accession>
    <name>F9W4U1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000605">
        <property type="protein sequence ID" value="CCD12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="190523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14676" checksum="331FD270A4A1AE10" modified="2011-10-19" version="1">MKDKRVYRHLRNEFAKTAAGIPMIQLCAALKCFVRGLVEGGETRSLDEQVQQELEREDMDAFLRFCVENLLPGFADGMEVKCVLAATESLYQLGYTSPEFYEKAARYLASKCSSASPPVNGSEPANTVCLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V5</accession>
    <name>F9W4V5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000616">
        <property type="protein sequence ID" value="CCD12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="EIARCEV"/>
    <dbReference type="OrthoDB" id="1668670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="363" mass="40891" checksum="6753134B329692CB" modified="2011-10-19" version="1">MEDCGGLDGMSLHDFLMEHFGETFGSPSVSMPMFMGNPSFFLRDESVLAMITNSSPYAELVRAYEIYNAMREGVDRLSARGIFSFLQWARADAANEMEGVNDSVRGKLNAALFIARRNEETIRVGNAASAVELDGVYDSVFNSKWSYVVMSDEYSKKWLGMGVLRVSEGEQPHLWSEEQADVPCKPWEPWEGDVVPGVRGKLVMAVLSSQKGWPYGFFQRDGVREEKVKSLTGYNAACDAYILKENLRVWNIAQENINRWNSGVGDVHPFVVIGMPGIGKSFATGSLLLYQLLHYLPEDLKVMAYFVRNEACIFHRKERRVVYYAEEEIARCEVEGMARRGIKGYMICDVSGNSVHIGDLPYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V8</accession>
    <name>F9W4V8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_31090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000618">
        <property type="protein sequence ID" value="CCD12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31090"/>
    <dbReference type="OrthoDB" id="1671733at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388681" evidence="5">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="38940" checksum="F1206A1994940917" modified="2011-10-19" version="1">MMMKFWTVLYLCVVGVIADTNVKNYNLEEYNALCNLLKIAVYKWSDLKSKGSGDPLKKALGRTLFGERDGDEVQSLKAPFPKDYEKVIGNHGTRYFWCGQRRKENELSGVNLPRSSGHSAPHDLVCLCTVGKDGWPVNDGEGKLCGQSKEIFKGGTKGWGTGAPGEVKEQIAETWNKVVTPCLQKSEVGESLRGALKIFKDRINKTISNEGKSGYLLGKGDPKNYPCSGNGQVCVMYYDSTDATEHPPWWVDLEEAINKDEAEQELKKREDEKRKKEEAKNQHHTHKKENSLPQHAPRTAALQSPPQDIQEAEQTNHDNISAPLETLEEASGTHITPPCSWFLGVLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W510</accession>
    <name>F9W510_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_31570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000643">
        <property type="protein sequence ID" value="CCD12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31570"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389892" evidence="5">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="42"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37444" checksum="709488EC6C4F0E1B" modified="2011-10-19" version="1">MWGNVMLLFVFPHYLVKAVNCHNELERELLCDIFRQSKRVLQKFEEAEPLKQAIYGATENNAQIINLGNVTLGTSCHGPVLRDQFCGYHGSKREKDGCFSESLLGTFFCVCAPGARRGYVDKLCGVSIKRDFDLWYGSAPPGNGEIEVIFGNVWGNVIRNCTGGGESVEGGSEELEKLIKAVEEVENKTLLGRDGLFYFGWSGGKDCSGSDRGDICAAYQRKDGSGSKAHIPWVEKIKKAITNLQKMEREGQDSDFRQIPTGKSSESITTLAHHAERYTELAVQSEGTVTPPSSDRTPSKTKISTKTSPITNIPHLATDLNEDGTSLTDQKWLVISALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W553</accession>
    <name>F9W553_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000659">
        <property type="protein sequence ID" value="CCD12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167673at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="457" mass="53308" checksum="A1EB835B37863BBD" modified="2011-10-19" version="1" fragment="single">MIPFVLPSLKPPPTGRTWNSRIRLPPQNPSFLDTVPKLVFPTVEASRCAEDVKKLEALRAEQRLSEAIESIERQQRKLRATIGRCEYEWRYHLLWQHQEEKAMLECCLEAASVSASARQRARYSQKVRDFEARGHVQHVEAVMRENIQVAEKDARDYIISLENVVSFKGLQRTATGEAESVESFLDSLKGVQEIERRIAQDSFRPPSIFEPVTQLTISRGCALNGSFRTPTLFYDSAPCKEEHVERVTTMIGEQLDRLIIYWEHDVVTSVSMRESALREKLYQLFRWGSCQLRLRALLTIQRWWRMLQAAPWTERCKKALRLCLRERRWRMTSADYHNVLSRMRKNQSPHGNLVSKNEVSVLMAALLRAAEISHQWTYEYFVYTLMNYARQMYELAQHDLGVGSSSRGNSSDLEGNNGELTMWSQTPMLMPNRMFLRLRTMQLYPQWRATRWVDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W575</accession>
    <name>F9W575_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_32160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000668">
        <property type="protein sequence ID" value="CCD12323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32160"/>
    <dbReference type="OrthoDB" id="1666421at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="68"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="46838" checksum="FD249D898ABCDA95" modified="2011-10-19" version="1">MPLLPPKKEFLPIMIIIYAGQHTVMHVYYVHILLLFIYLFDHLFIRCVISVSVVGMENVIRLLVVSVLVVVYAVADDKATTGMSITLQKATAVCHIARKLKGVSTYVAQKLEEYDQKIQEIQMMRDVVRLKVFMPGGEKLNCGKESAFLLYVYERLAAMQEVMGKLRQAGTKAAGSAGIAAGRLDEFVSVFKQAAGEPSDRNFLNTCYKGSGSQNIFYGIGDDTDKQYGDGVKSLGEYIDAQFTLSGTGTGGSGSNGETLAHVKNSNYYVHEHAIVHGMPWGDGIFTVQGGDQGEWKQVPSKDVTVLRSAAEDYQVFVSLLKSIHSIYAVIKADWVKNKLVSDNTIRNVLYTIKTTEGQKRRVSEEDDNSPEGPPWFPTWNPSNMRNKLLEDELTLCEEHKRSGTAVVSIPLPLFLCFIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I5</accession>
    <name>F9W5I5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 132</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_03390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000717">
        <property type="protein sequence ID" value="CCD12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03390"/>
    <dbReference type="OrthoDB" id="1722147at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20655" checksum="1E85283DB28584F7" modified="2011-10-19" version="1">MSRSRLSHYGTGATHSRGTKCWPPTQGTQRCWHNCSIILERGCSHAPTSMERRVSMRAVYWLLECKPTKPQGYPLVRRMLTDNEDNTPRSGTSSDLLSLICRTIRAITEAPRPSRTSIAFPSAHDPQSLFLSCCVVGGVFRWDFYPLCLVLLHTVCSLSFFIIFSFPCLCTYLLFFFLCGVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W681</accession>
    <name>F9W681_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1432</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_35450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000832">
        <property type="protein sequence ID" value="CCD12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35450"/>
    <dbReference type="OrthoDB" id="1664678at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="438" mass="47731" checksum="AA8B5B6E4FFFE3F4" modified="2011-10-19" version="1">MFSLSFSLGKKGIAVVQQVRMRGFSCVVSLWVVVLVSGRASGNNGDGVCKLNENAAGLLCAIAKLMEKAHQITETHDYKDIDGTWGNVELHKDQVEARTKTLQTEIEAAKHKGTLTDEDGKRLTNVSLDAQDKTLEEHKKAENAIKAHNGTHSDAKSSTSKALGGTRVEGNCHSTASLLGIIQCYVKGETPQGDVKIETLCNGKDYQRHLSEHFGESIANCNGIGKRKTYCNGTGSALKAVLKRWNTTDKTKADSGGTCAVKGDWEKHALNASDQMHQLDKNVQTIHEANLLTTSYLSIIHQMQEDVKNGKHMKEIVANARKAGQEGAKVVVEKQDDNTGDGTEKQSGKTASPVEEEVKVTVQLDGLKFDEENMPAHSKETFPKFYIYLLAILLPLCCLVIGVTMFCILRRVRSTHAEKSIPVDGATMNKVGGTHAQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6B7</accession>
    <name>F9W6B7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prolyl endopeptidase</fullName>
            <ecNumber evidence="2">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_35790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01000847">
        <property type="protein sequence ID" value="CCD12722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35790"/>
    <dbReference type="OMA" id="NMGAGHG"/>
    <dbReference type="OrthoDB" id="1124637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="4">
        <location>
            <begin position="23"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="493"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="715" mass="80583" checksum="0A2C2E52C7E585F6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T8</accession>
    <name>F9W6T8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000936">
        <property type="protein sequence ID" value="CCD12895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37330"/>
    <dbReference type="OrthoDB" id="1725433at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17239" checksum="7DB2F49578AF3B50" modified="2011-10-19" version="1">MAPLACGMSGVMAGVSHLVVCPQAVAFFSGGSRALREGTESERHGHTSGIMKALMGLRCLLEAYSLLSLRAAADVTTSLLDLKALFPHVELPCEALRLFCCRATNSDEWRELSPVLVSGVSRVSSHLSVRCVARAARALFELTNKVLQQQWQDSHGTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W744</accession>
    <name>F9W744_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000980">
        <property type="protein sequence ID" value="CCD13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17074" checksum="C7C2B1EB82D19C35" modified="2011-10-19" version="1">MKMEEGVKKVENEERKYKTMLNGNLWFLSEAIKDKANKLNISPSLGVPMKNNEIKKNQNYYTIMDEAKMIKDKILKNQAEILLRKSKAWIAYSRDNADETSNIDDMNVSHFFDVGKINPQDTICIYIFHLIQTLNIHPATMADTGCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7E8</accession>
    <name>F9W7E8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001014">
        <property type="protein sequence ID" value="CCD13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38990"/>
    <dbReference type="OrthoDB" id="1685923at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="32893" checksum="AACA15B0DA114654" modified="2011-10-19" version="1">MKGEFNLVLLSTRVAPQVTFQEGEKAGSGELVVLFALVIHLLKISPFCFYICTRHTQKQNVRLKYLPFSWQKGKTPWRQVQQMIVRGHAVGLLLAVVARCLAPGVSPFGYASAANKDVNSGSGRHEVGDSEKICEMAAELVNTMRKAGALGKEVARHVEEASAAKERSRSLRLRSEAAVQDANDAAESTSVYGISGSAGGEKAKRVFLRVDAAFEGFRKAARTVSALVSLVLERAATAELKINETEKLAQTEVNNTLSLLDAAAKEVHLLIHAMSRPTAPKRCGGVLVLGGQLELQREDGKMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P9</accession>
    <name>F9W7P9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001063">
        <property type="protein sequence ID" value="CCD13221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="362" mass="41767" checksum="9FEC8F376574AFC6" modified="2011-10-19" version="1" fragment="single">MDLLRYQRNQAELARRNHGSPNKQQRLSSNRAGQSGLTVEVARRFGSCPLAKKPETHRKVRPRFPTDPAKDLEKGVTTLARKTTSLVSTEGSDLPLQDVVVDTLDIDTLTRIMTCKVRRRFKYLLSLFVSTNAETTYRAKFMLSDADTKQLSDNGIIERINHADIQGFAWPFCVAELKKKGWRRRMILWPQEGNEKVRQLFHYKPSLNLYNRIKYVSSVWHDGPALRVDLKASFYQIPLSSEMSQHLAFWAGSRDNGGWYAFKRLPMGHTLSPEIMQLAMSSLMCDERFTMIPRLLRVCSIDTWLDDARVLAPSLKKLEATSALIKFRMRTCEATIGEWEIAHDYEFIGIHWDHRHHMVSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7X5</accession>
    <name>F9W7X5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001099">
        <property type="protein sequence ID" value="CCD13297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04370"/>
    <dbReference type="OMA" id="WAVEASK"/>
    <dbReference type="OrthoDB" id="1754837at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="652" mass="73988" checksum="334444C4B5BFE68B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W814</accession>
    <name>F9W814_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001120">
        <property type="protein sequence ID" value="CCD13340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41020"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18958" checksum="3115266E8C2A2A2E" modified="2011-10-19" version="1">MPESPSSPSPEGMAQETPWNMEKDVVDVLLEGVLPAKEMNLYGFLMPVSPHLTEFHTHFTLRDFVRTPRRFIEEEDGCDLIWQNLPRLVWKFKECVRPRLRHYGHPDGWKAAQWECWEILIHLDHPPLDVVGHQKYSTNRYRGTFFLYRPRRPSSTCRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W835</accession>
    <name>F9W835_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_41180a</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001129">
        <property type="protein sequence ID" value="CCD13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41180a"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="117"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="318" mass="36002" checksum="C7718485AC74707B" modified="2011-10-19" version="1" fragment="single">MPHEMSSTPTGLGCKFCSFHALILDALEMLHGSLLVTGFLAHIVLLATSDMENEHEKLIFCLIRLMAEREPKELVFRNSVEESEIVSRIKQLNSSVMNFHRMKVGGSERRYVDKRSKEYGREIHKILEAALHLKAEADAYKFQAAAKRDSARANLKRVIYGDAMNFTAEDTDIQRRIDDNTSKENVFQDIRDKGKSCSGPGAGRSLINDYFCLCFTESHFGSNEKSYRGVCGDGIVETTWDDTKEGWLAKWHKNKDKGCERFQGRLPSPPLIEEALYLFNKTVDVSHTKYHEKGVFGHHQPHDVDGKPISCDGTGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W856</accession>
    <name>F9W856_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001139">
        <property type="protein sequence ID" value="CCD13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41400"/>
    <dbReference type="OrthoDB" id="1700269at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22035" checksum="1A781F65E024C312" modified="2011-10-19" version="1">MVGRCTAVRVASGTRQEPSVPRCRCDAPLFSQYGQPELGRLVVSYFPPQQRTSLQYRFSGQQSGKEQTERTGPPLTAPRVGLGLRCISARCLSPLHARYSVPSRAKVSLERQPLLSCALRSVQYFSLAFPTPLPSRHTVFCSCILVRSLPVPPFSRSYPADKPELQTGHLITLIFQPTPVDHCPQSFHSPHGVHFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8C0</accession>
    <name>F9W8C0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001160">
        <property type="protein sequence ID" value="CCD13452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42010"/>
    <dbReference type="OrthoDB" id="1692341at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="241" mass="27735" checksum="340221C3AE54C0B5" modified="2011-10-19" version="1">MPIPLTDPLYPLPRASPSFSSHIRNIFRSKSKGTISVALQQLPSLFSYFYHQPHVALLDPQRTIQRKSEICICLYKSGRQQVLRHQTDIHSGHRKQNKKEKQIKATKDYLFLLHSHIHQTSGNSSIRLSFLSPPRSSIYTLIPCEGHSSPCAAPTRRRHRSADTLYKRKKEKRKKKRKQGENKNTKLETKSMSKFTITYPTSYPSHPLLLHCGIVILFIAHHFRMKKEAKDSLVVCPDMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8M2</accession>
    <name>F9W8M2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1747</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001183">
        <property type="protein sequence ID" value="CCD13556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42980"/>
    <dbReference type="OrthoDB" id="1717362at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17528" checksum="8D467275B969F7DA" modified="2011-10-19" version="1">MIIHSPCTQHIAGIGNSSAVTLPSALVCCLHSILRSTVHTATPHLSQPPFNHIVRSSSHTATQAALTAYFHFTENNPTEFHSLLKRAHTQVSPNDTHSKHHPPIPNVATGLTKLQGLYATRGLEFGFPARLGWLLDREGYFPVCPYLSHRLFMLYRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q7</accession>
    <name>F9W8Q7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001199">
        <property type="protein sequence ID" value="CCD13593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04530"/>
    <dbReference type="OrthoDB" id="580796at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="41102" checksum="52E9948DFA296CA7" modified="2011-10-19" version="1">METQEQATLKGPEKSASKEEGALAEPKKRGRPRKATQTPTVTTSDAAERAEGGKTLSAEGKAMAGTSLGEESGEAARGMKSENVALGGDTELEKAKGSKEKRGRKKTKDLKDARKKKVGKKQKKAAKKAGRPQKNTKEKKSKGTKLKKEKREKAKEEGDAQGKEASKGEHTQERTTERAKISESTETVTLKEVAEAQGVLEKPLVEGRSHSEAAEAVVKQKQDRKQPTPSDAKAAQIESKDTPSKAPGDGEAVKLSPELVAELKGAPPLTFDNSVTVDRFDGTNLELRRPDLNTSWDIRMSHGGEHVFLTRLPPLSTTLKAHPFMKTLQPDETGKISWQVEEVNGIDLKNASKPIRSQAMDSIKKSAKVSFILRRLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8T1</accession>
    <name>F9W8T1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1774</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001213">
        <property type="protein sequence ID" value="CCD13617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43550"/>
    <dbReference type="OMA" id="DVKMDAM"/>
    <dbReference type="OrthoDB" id="1655910at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="742" mass="84505" checksum="A1D2AEBD1498F924" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8X8</accession>
    <name>F9W8X8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1796</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001237">
        <property type="protein sequence ID" value="CCD13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44000"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="134"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="39282" checksum="3824AC093A2AB753" modified="2011-10-19" version="1">MSAHLRHPNRQCALQEALRQKLLLCGDVEANPGPLKVLQLNVKSLTKTKLSSLLSRGSDIIIVQETWKSEKEILSLKTHPYIMYSYSRRGRGGGVAIMVRNTLKSRQVTMKIPEYDTNTEAVLVEVILRNGSNMYIASVYLPPPAVVTSTLHKLVTTVPASSPFLLCGDFNLHHPLWALKGDEAPSDTAQKLLDITLDANLSLANEPGFTFARGPTERSCIDLTFQRFLTVECWTARVTIHSDHFLIKFSVRASHRNEIPPAAPVRRRHFYSWKKCDWDSFRNKMDSQLPNFDPRNIHRNIKAFTDCYYTALRRRYPRGMIKDGPIFWDREIIEAERYVETLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Y4</accession>
    <name>F9W8Y4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_44060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001240">
        <property type="protein sequence ID" value="CCD13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44060"/>
    <dbReference type="OMA" id="EQRTGRH"/>
    <dbReference type="OrthoDB" id="953860at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="3">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="27906" checksum="41C162ABA98EFD4A" modified="2011-10-19" version="1">MDFFRRTFNNIKLRLHISKVFQEASKYPVVLSPECLELAESYPAIVAAVIGDSLGKSSTLHVYGYLLLLEKLVNSCSSAFHSAMAQNCALQENLVLLATGRADGAERRRSRHLARLTLLEYSRMFADVPELRSLATLATAAEQRTGRHLLRAIVLENKSVRIIEPRPQDIVVFSPTESTAGSAVQTELPAVWPCSICTSMNRRSDESCLACGATRNKEDGALSFLKKSALSSGMGDHVGTCTESKSNAEMAGPAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W954</accession>
    <name>F9W954_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1818</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001262">
        <property type="protein sequence ID" value="CCD13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44520"/>
    <dbReference type="OMA" id="GAHLMMP"/>
    <dbReference type="OrthoDB" id="401807at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="PTHR12217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="567"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="660" mass="74150" checksum="10206A124DD757CC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I0</accession>
    <name>F9W9I0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_45700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001313">
        <property type="protein sequence ID" value="CCD13880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45700"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394625" evidence="5">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36393" checksum="300C4127EEB80715" modified="2011-10-19" version="1">MILGMRAWVMVVVVWVRIVIGEESPNNHNKNEYEALCSVLSSAVTIFESGRGSSALKKALEQAIFGSKTQQDKLESLLWALPQEFQAPGDRQNWCGVCANSHHYPGKSIPHDMLCLCTVGGAGYPFSYGASTLCGKSARELGCSGDYRTDCSGSEGWTESKHGEPAKTHVRATWDAVVKPCFRAQSPNSLEETRNTLMKHLKPPDGYSPIWGRGHSYCGGTGGNVCLNYPNPCGPTNFPQWVKDLSEALEKEDFAKAENTSTGPSTTTPKRNGVQPQVGRTLERGGEYSQAAKEAEIETPQHHTNDGKPISHPSEKENDSTIISPIGLLCVALIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P8</accession>
    <name>F9W9P8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1884</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001335">
        <property type="protein sequence ID" value="CCD13952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46370"/>
    <dbReference type="OrthoDB" id="1721677at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="19734" checksum="6B12F6549DEEDD9B" modified="2011-10-19" version="1">MIGVVMASLPVPRAGSSYPQPIPSEPKRSPLYTQQECKRCPALPDREAIRVPEDPFPACIQIVSRGASFSWVSRLPEKRKASCRKFGIFSKRLTNQGADSLQRSSVPPLLLSSTVSVWASSSPCSRGPEGERASWIEPTNVGRMMGTAPPRRPFCRTACRSVRDSKWGAPRGQSSCTSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9S4</accession>
    <name>F9W9S4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001342">
        <property type="protein sequence ID" value="CCD13979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46630"/>
    <dbReference type="OrthoDB" id="261724at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPP_II_complex_TRAPPC10_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAPPC10" evidence="1">
        <location>
            <begin position="123"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="21281" checksum="B36BAC78F1B4E4B8" modified="2011-10-19" version="1">MSMECQCIQGVTLHSLEPIISTGTELVSVTAGPLPCHIEYMEVFTVTTKLRVLKTGRLLLGFVQMLLSPGSSTQRIASGFSLPEIEVESSTLELTVKYPPTATVGSHFTMTCEIVNKTAALQSCQFTMEKSNAVGLISGAENWNVSIGPHAACETSIVLRPLTTGVLHLPSVSLKHSSGGSYGSVAACQFHSQKICVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Z0</accession>
    <name>F9W9Z0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001364">
        <property type="protein sequence ID" value="CCD14045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47250"/>
    <dbReference type="OrthoDB" id="1722927at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16107" checksum="8066E45C31E28DF5" modified="2011-10-19" version="1">MPRPGRAERVHLGMCTIGTVQQVSNSGKRLVAFLSRAIRVSGILKNGPPQSGSDKLPFPSSLIIWIFCFLVFLLTHSSTRNVAPCGMADGGTCHLVARIRGAKRTPVAMLKGSMKKSGVCVVFCVAFGMSGGLDNVVSKSPKVRNAVHKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAA0</accession>
    <name>F9WAA0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48160"/>
    <dbReference type="OrthoDB" id="1688985at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="254" mass="29854" checksum="4CD0C3FD6AB7E036" modified="2011-10-19" version="1">MLSKQQTECGECYQSSKQNVKNAIKAANRMWRMLSKQQTECEECYQSSKQNVKNAIKAANRMWRMLSKQQTECEECYQSSKQNVKNAIKAANRMWRTLSKQQTECRERYQSSKQNVENAIKAANRMWRTLSKQQTECRERYQSSKQNVENAIKAASRMWRMLSKQQTECGEHYQSSKQNVDNTIKAANRMLRTLSKQQTECGECYQSSKQNVKNAIKAANRMWRMLSKQQTECRERYQSSKQNVENAIKAANRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAB4</accession>
    <name>F9WAB4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001410">
        <property type="protein sequence ID" value="CCD14175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05180"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394802" evidence="5">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="97"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="50491" checksum="81B2B07BFEE994B3" modified="2011-10-19" version="1">MRKTMCILEFLFFMIFFGGASNGASETLYNEEEFKQLCKILKVAEGEPAPIPDELGKFLETRKILEKLLRSTKTSMATYQKVIQLKSSDKEDAEFVSYTVKRRIANEKIKHAMEKANDVYNRMEEELIKAKKERTLARSNLVHAIYGVQVGELPKEENITDVLQNVSKASIFNRWGGNKKINVHDDVPKDPTCGATTGEGAGFTLINDFYCLCVGKDNAKAVCHEKIRGPCCCCKDCTKSCQCDNSCDCSNCNKCEGCEHHKSWMYLFDVENSKIVDVPEGWKLIREACNGTFKEAVNTTAESIQEVLDEFNKLLGNNTKKITGNSDAENESRRLVVLGYVSRMNGDYNSCTGKENAVCVDYWTVLNNRHGIVWHTFMVQAQKHLKTMDKHVKKAQQLSAMIQKLKESAEESYRNSTHGSLLWSEDKGFRKNICHLFFVFLAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAE2</accession>
    <name>F9WAE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001422">
        <property type="protein sequence ID" value="CCD14203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48500"/>
    <dbReference type="OMA" id="DETDEMW"/>
    <dbReference type="OrthoDB" id="1699337at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="247" mass="26796" checksum="5ACBD04EFF48745D" modified="2011-10-19" version="1">MLTPGIITTTGDSGCHGPAYAGSCCRDEVQTRKRKCARSTTPRFTSPISKKATQTSWMSSAGGSTSCGAAATSSWHVAEDFCEDDGSGTPYSSSSLSPVVSNRDDAGYNSEELLEEQREFSQRRAKKYVSEVARNRDLHRSAMVSRLPKSPAVMQFYFGIAQRDATAKGDYCRSYSEALRMHQCVTEEEEGSMVGAEGSPSRGKGPRFLPNSALKFTGNDIDVVRTTALLLMEEQEKESRASGGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG4</accession>
    <name>F9WAG4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_00860</name>
        <name evidence="4" type="ORF">TCIL3000_0_05230</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001432">
        <property type="protein sequence ID" value="CCD14226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002062">
        <property type="protein sequence ID" value="CCD15804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="T01.983"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00860"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05230"/>
    <dbReference type="OMA" id="GWGAIVH"/>
    <dbReference type="OrthoDB" id="1170036at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF62">
        <property type="entry name" value="PTHR11599:SF62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="205" mass="22457" checksum="599B5B33588C923F" modified="2011-10-19" version="1">MSILTYSGGSCLAMAGKECFVIISDNRLGEGLKTISMDVPKLHVINDGIVMGLTGLRTDQQTFAQKVRFRTEMYKLREEREINGKAFAALVASMLYEARFGPWFVEPVIGTIDRKTGEVYLCATDLIGAPCEPEDYVCAGTCAESLHGMCEALWRPGLEAEELFEIAAQAMLSACDRDSLSGYGAVAAIVTKDKLITRLIRGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH2</accession>
    <name>F9WAH2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1973</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001434">
        <property type="protein sequence ID" value="CCD14234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48790"/>
    <dbReference type="OMA" id="ETRRDEC"/>
    <dbReference type="OrthoDB" id="1343160at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22535" checksum="90EEE2584BC67EA6" modified="2011-10-19" version="1">MSLGSVLAPYHHVLLQHYNILAFDELRELVECYGEVLDISSYCYGRKELISVVQFKDPASVELCYESLRSYTNDASCVISRVALIYGESLTIFASKDYVGSLSERETRRDECSYGYLVVYLSHVSGGVRSAFADLIKKDGNIVDYVLDLEDKERCFLCYASMIAAEDSRRALSIACPELKKNIYYCNENDFSSAKQKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW5</accession>
    <name>F9WAW5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_50060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001491">
        <property type="protein sequence ID" value="CCD14388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50060"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390082" evidence="5">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="37197" checksum="2A3D6D6C1BB6884E" modified="2011-10-19" version="1">MCKEVLYFLFLAMRVIPVGSHDNVFQKLCDITEKAFLLLKLSKNNAQVNQSLEAAIYGTDDRAHFDRDGGLTSTKGCSIWNYGRSQVCNFQNSGGCFAESLLGSLLCLCIPGKSDAKNMCGVDDLDTSAFWSGWSGPDEKENLFKNVWGNIKKKCTKEYGNVIGGEKNLKELKSAVDTIRDDAIRDYNGYFYFGGILTSDCSGSEKKNVCVKYKMDSNGNVAIPWADKINEAIQILEYAERSGENLGIAKSLASGNWKTVARKAEEKRSEHVSHEEDATQESENVSSTLGIKQLKTRNKRSTPGSQEAGIASISTEVTEDGSLITPPFSWLPFAALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ3</accession>
    <name>F9WAZ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2039</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001507">
        <property type="protein sequence ID" value="CCD14419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50350"/>
    <dbReference type="OrthoDB" id="157269at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20326" checksum="D0742B8D38598EDB" modified="2011-10-19" version="1">MCYPECGGPELGTRRLLFGIFEKYDVIPCSPWEDHAMQSETSSIRDRHASAVQHHTIFRDPMRCSSQDNGSREVYASSYTGRQAVTGEMLTIPSTSWSPGAKLLPAHPVRSTDDSPSFPASPAPELLTTLNSNSHGERLHSTGSLLRNLTLREKSALIVQLAWKKWKAHRREAAERAIVNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB43</accession>
    <name>F9WB43_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2058</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001528">
        <property type="protein sequence ID" value="CCD14474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50840"/>
    <dbReference type="OMA" id="SGRAYIF"/>
    <dbReference type="OrthoDB" id="1657630at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="585" mass="66575" checksum="6960577037850668" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB63</accession>
    <name>F9WB63_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2067</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001538">
        <property type="protein sequence ID" value="CCD14494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51030"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17335" checksum="24EA058E20CAAD95" modified="2011-10-19" version="1">MAPSCARKRKPIDWNADGTAGSIESRPTSRVQPVKATTEENSEHSQASHVAARQGDTIIFPLCNVASAHCQAGVVYWMKMHGIARETVLKPTKVGKEAFHAYNGDYDVFLPHVAPLPERGCWPFAPPVSRTSPNSSPMYTASKRNMEKKRKGKMRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBG4</accession>
    <name>F9WBG4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_52000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001580">
        <property type="protein sequence ID" value="CCD14596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52000"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390105" evidence="5">
        <location>
            <begin position="18"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="46"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="353" mass="38815" checksum="A26747FDD09817EB" modified="2011-10-19" version="1">MWRRLFLFLFLTLKVSPVDDYNKDVFNNLCGITKRASSILRLQEWNANVKHDLEEAIYGKRERAQFNKDGEVDFGGDCDLFDSGRSQLCSFKGRGNQGTGRNGCFADSLIGTVLCICTPGNNNPKDLCSLGGLETVGVWSGWELREHEKNLFKKVWEKIKERCTSVTRSELIREDHSRTLKKAVTNVTSKLRYDNKGYFYLSGDGAGDCSGTNRGNICSAYKGSDKGIAKVPWADKINEAIEKLETAQATASTSTSPIRMSGSPAAEGAPGEKIDLAGQNEPTSHETHDQRESDVTDTQKGPSTGHSDTAKSRGQRSTQRSRETDTASLANDPEEDGTLITRQKCVLIAALIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBG6</accession>
    <name>F9WBG6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001582">
        <property type="protein sequence ID" value="CCD14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52030"/>
    <dbReference type="OrthoDB" id="1695978at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24751" checksum="FA33F79C27A2C5F8" modified="2011-10-19" version="1">MYHHLPSHTGPHXLSRGAQRGILKNGPPQSGSDRLPSPPLVESGFSVFANPETRIALGKNATSLSPLFDTCWTVPIVHIPEWTLSARPARRGIRVGEPTAPETFQPVDVSVSSSGACVLTALPVLLPSVFPYHTQHAPGFLPLVKSQESLHEALLAPWTPRAFPHAALYDASIQKPRLFLCRFGLCCLDNDVAAITPSLIIAPGSWLLTLSCPFRDVSTMGIQQRSVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBM9</accession>
    <name>F9WBM9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_05530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001599">
        <property type="protein sequence ID" value="CCD14662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05530"/>
    <dbReference type="OMA" id="VFMNREW"/>
    <dbReference type="OrthoDB" id="1064706at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="64"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="30473" checksum="8003BD7642A9B32D" modified="2011-10-19" version="1">MVSYAYALTKDGRRRAPRPLFGVSIVKPFPWLRIALGIGGMAFLIRREYKSRYEVSPREQFLRKVAVTPYGVLGMQVSLQGGLVRAGSEPDEGTCIVDPADLRHIFTTATGAEGASGAIYNMLGLRGPFPDDVVQAISRLCDAKLHKYSEKNNVIHVIDPDFREGTWSEREAALELSRAYRNLLHEFVGGEGDVLRVPPLSSGQRAGPLYSQLSIITQSAMAMAFDQLHIFDREYLLRRDKRIELCVFMNREWDLYQSVFKNCTQPTRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC15</accession>
    <name>F9WC15_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001653">
        <property type="protein sequence ID" value="CCD14802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="13471" checksum="44AF2B7229D76E21" modified="2011-10-19" version="1">MSSLSITSNGGTSDTPTTSSPRIPQKRLDPSASDTTASKQTLPSHPRDALDKSQQAVFLQSTQITEEPSPHKRETLQLAQTNAAFAKPSAQPRKETGESTAASATPTTDFTVTLSSAPTASATVTACPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCB1</accession>
    <name>F9WCB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001696">
        <property type="protein sequence ID" value="CCD14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54740"/>
    <dbReference type="OMA" id="DQHANSE"/>
    <dbReference type="OrthoDB" id="1656544at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="227"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
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            <begin position="1144"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1178" mass="128715" checksum="D998A8FCA80797F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>F9WCB5_TRYCI</name>
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        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2211</fullName>
        </submittedName>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
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        <source>
            <strain evidence="1 2">IL3000</strain>
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    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="CCD14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="17860" checksum="5E74F1626F2A73E0" modified="2011-10-19" version="1">MEFIREKVSTSFSFDFRPAETPSVTCHVGGLLTIEDVNLMAYFDCERKMDFVSLRQSMVRFTLPGNSDFLRASGEARGALRAEWTALEATESALHNQFNSACAHSSQMRVSTCSKVRMSSCSECNNSSCVCIRDCCTAGSAVGSERQNDCYVTGAAGWLGCEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCN5</accession>
    <name>F9WCN5_TRYCI</name>
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        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2251</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001743">
        <property type="protein sequence ID" value="CCD15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="AECENAK"/>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
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        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
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        <location>
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        </location>
    </feature>
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    </feature>
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        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="39852" checksum="5F9B49C7176B74EC" modified="2011-10-19" version="1">MTPRCVIPMAPLLAATVTFVVAENDQEPADGKLNPDATKALCTLHALATSLEAESDRLMANMRDDMRYIENTFASAKAKQEGFGDIVEKMQLDKTGEMATKGEFAETLAAIAKARDLAKKQLSVAANVSRVAVRHAKEAIGKANGTGLNAVMLTYCNTTKPSGRSSRWFKVTNGTCGGGLVVPLNGSIYRIDCAGAAKPDASAVGSVTYQTMMLALRAWEAHKPKPKSMASDWKSTARREQKGCSKDGYSSEVACTASEKGWVGHYNSSAKELRKLEGASHAMQAAATEAKKQFEVVLALENLVGLARGGFLPTREVGAECENAKQGTRIVPYLIATAVSFVVVVPGFLLCALLLNCGRKRKDTVPSAECVGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCR4</accession>
    <name>F9WCR4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56260"/>
    <dbReference type="OrthoDB" id="1695500at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394680" evidence="1">
        <location>
            <begin position="25"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="210" mass="24528" checksum="927366712065283D" modified="2011-10-19" version="1">MRWFHGAPCGFLLFLLYGPHMGNAFLPWRRSFVCTEGEKLLEKVEDQFSQRLKSYAAMLNSTDSLQEHCESLKKVLATPPEQGTTGLRHREETWGKYYTAFLRDQTLADEFRDQVKSLIQDIKRHCGSWIGFYLANWGLHKRLEQKVVDGQRLKQEFDDHLSRVHALWAQANITGCSPEEYERMVQAYQELERERRRKATDDKASQVGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCU6</accession>
    <name>F9WCU6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_56560</name>
        <name evidence="5" type="ORF">TCIL3000_11_6160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001767">
        <property type="protein sequence ID" value="CCD15094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.6160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56560"/>
    <dbReference type="OMA" id="TFRETQN"/>
    <dbReference type="OrthoDB" id="35378at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="PTHR10102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC95193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1278" mass="143963" checksum="300C35F568DF5D4E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDK6</accession>
    <name>F9WDK6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001880">
        <property type="protein sequence ID" value="CCD15360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15698" checksum="F64C894D92CD1178" modified="2011-10-19" version="1">MIHDTFFSFASPFVARVFIIVVVIVLFLCMHYTRYFFSCVSVKGLPIRLALSYIFMNKHAHMRLCNRMPPTTCSFGHGFYLLLHNDGFTYTKIFNLACLHLGEHPQQIEGWIEIQRVASRRRRVRGKGVNLSAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDN5</accession>
    <name>F9WDN5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001891">
        <property type="protein sequence ID" value="CCD15389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59150"/>
    <dbReference type="OrthoDB" id="1653706at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="806"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1346" mass="149502" checksum="BF99CA47065D1BE5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDN7</accession>
    <name>F9WDN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_59180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001893">
        <property type="protein sequence ID" value="CCD15391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59180"/>
    <dbReference type="OrthoDB" id="1506658at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="PTHR13000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nup54" evidence="3">
        <location>
            <begin position="184"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="41866" checksum="D26A155B8FF31580" modified="2011-10-19" version="1">MMGTLGGGTAGAAPAGFGTANTSTATSGFGAPAGKATTGGGFGTSNTGGFGTGATTGGGFGTGATTGGFGTSNTGGFGTSNTGGFGTGATTGGFGTGATTGGFGGGMTGVSGRPTVMGAAQQSAVACQSALARYLLEFDNAYNAMHPNCRFRAFLYNLCTPGQSMMAVERERLIYTAAGGDSREEDLLRAQQRNPDPVRMYPTRVHFMQELKARMDKQKEMLAAMLKHVDSLISKAEYFRELDEENGAQFSELVQEQAMLQRRWYTLLRKVETLRQLGVPLAEESRIGGITNALSAQLAAPDMYRSALKELQPFLDAESAMVTSLVRRHSAVATDGMERGTAANSGALLNNRVDRALMRDWVRYAERIQQGVESLNALLERDTRDMRAIHRHLVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR0</accession>
    <name>F9WDR0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001899">
        <property type="protein sequence ID" value="CCD15414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06080"/>
    <dbReference type="OrthoDB" id="1713662at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18833" checksum="5DCDB72C256AB01B" modified="2011-10-19" version="1">MSVQRRNEASDKPTHQVASTPSTQHQPGGTGDNEMKEILWKACKSWEDVLLLLFLTQECGRTYGACNPNVALAAFLEDPSHYIEEDERRKEAVEKLPQKLHQLKGCIFRDVPFLRAIGITTREQWAYRRFYHKMLTPITNYILLRACGSPLHGGTNKEVTLTVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR7</accession>
    <name>F9WDR7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001901">
        <property type="protein sequence ID" value="CCD15421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59430"/>
    <dbReference type="OMA" id="RNDFVHA"/>
    <dbReference type="OrthoDB" id="840669at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018216">
        <property type="term" value="P:peptidyl-arginine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PTHR11006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="301" mass="34157" checksum="7D3D8DDED3AD387D" modified="2011-10-19" version="1">MPSDDNAVSSNTTTDYYFDSYSHYGIHMEMLKDYHRTTSYRDAIWRNAYLFKNKVVLDVGCGTGILSMFAAKAGARKVIGVDCSTIAVQAREIVKANGFEDVITIIQGKVEDLQLDEKVDIIISEWMGYFLLYESMLNTVLYARDKWGVPGVKMFPDKANMHVCGVTDHQYIKERFDVWRNVQGIDFSYFKRLSFLEPLVDTVERSQIVTNMARLVSFDINTVKEAELSFKSEFALEAQSSRGRRGSAGRAEDVENDVCVHGLSVHFDTPFTAGHDVVVLDTTPLAPPTHWRQTVLYLFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE10</accession>
    <name>F9WE10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_60210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001936">
        <property type="protein sequence ID" value="CCD15515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60210"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394702" evidence="4">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="82"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="47075" checksum="9AF2D744A9501657" modified="2011-10-19" version="1">MIMINTFLLVALVFCVGLGSAQPSAAEFNLFCRILAEANDMMYGPGYVYDENADRDIVKEMEVLYNATTANMKDFGNSLWDTKEFLKEHPPPMNPQNREDAHREIDKLIKEGEKKIEENKKIAEGVNKEINSAKLSVAQGIFGDEVKELPKQDGNLTKILNNTGSIFNHHESPSQSCGDGNKETGKTLLNDFFCVCVGDGDKESAGPCSPHILPSKHGNESNGGWKKMKIKSGEAFQFNESFKHIEKVCTEELVVEKQPIKNMDALLDEYVGMIGAGPAKEANGNKIFGHRGRGRGHDNANKVTKCDGTGSTGDYDKADYHNENICVDYTNHTQDGINYNIPWHNKFKSYTDFMKEAKKLEDQILKNRAALLLLKTEAWLAYSREKDDETSNLDDMNISNLLDGTQLPSFSLLLSYLSIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE14</accession>
    <name>F9WE14_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001937">
        <property type="protein sequence ID" value="CCD15520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60260"/>
    <dbReference type="OrthoDB" id="1717509at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19999" checksum="69E99CC85755E1D2" modified="2011-10-19" version="1">MRDNWTSSSRCFPTRRRTASLTESTTVWVVGETQQTDGICLTVFRIEKKLEIGEHNLAKIPERMPNKEPDLTTALENVNHSAVEAYFRRIYWVDIHACCNLINGKKGITSSGLQDKLWWGGGILTIGKGFEGELKGEKFGPGEIADARDSATTWTGFPHTIPHLQKPSPHSSFQNTAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE67</accession>
    <name>F9WE67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_60590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60590"/>
    <dbReference type="OrthoDB" id="1667464at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394929" evidence="5">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="100"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="45510" checksum="4BE19CC495591CE7" modified="2011-10-19" version="1">MHVRTAITRTLLFLLTRLVPPSEAAEAVRNRAEFSALCWFWRIHVTADMILETTDHQHLSPESLIKHRMLVEWLEDDGNHAAWGLDARLSAALWYLNETERDTAQKMYDAFKQKRQEFAQLEKAIQQKANETRRVLETVRTRFRMAAYGHTRKDEPSERWMEEAYSRDTKRSDACTLKNTRLPGQPYAGSSLVNDLLCLCLAGRPGGGDDNAQICGAELEQKDWKFTWTDSTGFVPEGWAEKAWSIMGPACGQVQRPTDLTEKNILAASNHFESLIGTNPNPNRDKFPWVLGYSGQGQEGATRRVCSANAGRPNEAWGQCVHYANTTGGGRGRIDWLQAFYDLLPQVRQYEALQRELEGLDWKVKALSQDLEEAFEEAGFKNQAPRKPHHGLPLLVWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEA0</accession>
    <name>F9WEA0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001964">
        <property type="protein sequence ID" value="CCD15606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60920"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="22482" checksum="AAE7CE16BC30B775" modified="2011-10-19" version="1">MEVIAPSKFVRVLPAQGKARWDEFRLISDKLISQRMKRSVKDEDALNEGVKKGVRQAAEKAIHKGNGVVPPFWTPELTKLDVMVQQCRNEQKRDARIRWRRKVLEDTAIRRWEDNVSRPTVKDPVSWNLVESIYAPRPLTSPVLVVDRHSWLKRQQAQALERMYKERLTKAPKAPDMQIPSTRHETFKPIRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ7</accession>
    <name>F9WEQ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002052">
        <property type="protein sequence ID" value="CCD15773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07840"/>
    <dbReference type="OrthoDB" id="1713209at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21513" checksum="DD452F53632C9256" modified="2011-10-19" version="1">MCKTPANISPPVPVLPCRLYYNHLPMPCLLRRVPTAVRCNNRKWHARYFISLLVQRSHLHSYTNCHSSCVIASGIPFISFVHRYTFSFFLFSILPGGMSLSRFHTVVHGSLDINQILSSTTSKWKQVLVSFLFGRSFSFSFSFFPHRYCTTKITLISLPLVISFPANFCFLTRSLRLSLIFHTSTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEY4</accession>
    <name>F9WEY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_08470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002077">
        <property type="protein sequence ID" value="CCD15850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08470"/>
    <dbReference type="OrthoDB" id="1666018at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="67"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45012" checksum="A7EF1132BDB2E064" modified="2011-10-19" version="1">MYFLFLFGIEIGRMYPRRIGTSTWVAIVLAITMVVKGVRGGVYSDEWELNGVDHHHLCEVFKATAELWEASRQSEMKLDSGLEAALRQALFSNVGKKDLASITEAVPAAYRPAKPVHRGTWCGSCKNSERYYPGRSITHDLMCLCSAGYYGNPFYGFYLFFFKETGFKLCGRERKDMIKDRHHGWYAYNGYGLTKGLDKPWRTIVWGCVNSREKTFGTGIQDLTAKVKKLSGAMKNFTAILKVVNGRYKLGGFQGHTESDGSSETNMHVLYDTCDDKKKPWWKRLNETLTSKTPEQLLVPRKTQSPSSEPSEELNDGPEEELLEGFAGEEGLEPESSTADGGSAPQVDTENATQIQGPTNSTESTVIPLNATASGNSSHPRLEYLRSGSHINQPLLFLGAIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF38</accession>
    <name>F9WF38_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 345</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002098">
        <property type="protein sequence ID" value="CCD15906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08980"/>
    <dbReference type="OrthoDB" id="1709807at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20684" checksum="1A30B7FE43475680" modified="2011-10-19" version="1">MRDTMCASNTSLHAKELHCGSRAVLRCANPWTAGWLARYAMEKKEVRPSCKKPGLSSLSPPPAQNRRSHCQRMCICWSRRFPPRSSGFAPGESWLKDGEWESIKNAPTQPPLHAGLLLRQGSACTRHGCTKFVLTSRRPHVSRTPCQLVFQEARRLDHLWATASPGNVANANVPSQATRVITWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF71</accession>
    <name>F9WF71_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_09250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09250"/>
    <dbReference type="OrthoDB" id="531253at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="884"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134935" checksum="ED4B751C1210B9C4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFD7</accession>
    <name>F9WFD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002132">
        <property type="protein sequence ID" value="CCD16005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09760"/>
    <dbReference type="OrthoDB" id="92354at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="531" mass="60747" checksum="49102CF72C24591A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG9</accession>
    <name>F9WFG9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_10080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002143">
        <property type="protein sequence ID" value="CCD16040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10080"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394988" evidence="5">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="45"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38084" checksum="AE5226D0072DA885" modified="2011-10-19" version="1">MMKALFLVMVCLVFMLLHGRTTKSHNHNGEHYGTLCDILATAVQKWKSTNNPTAKKTLSQAIFGHPNGKGDPSKLDLPSTHLKPGNRKNWCGECMHNDQESYPGKSIPHDLLCMCTVGENGYPFIQYSEVRQLCGKGAKELGCDKDAGNAERCHSDNNKHGWTESNWDGQASKHLNATWHAIVKACLRGKPKPDVDKARKTLLQKLDVGEYSTPSWAWGHSGCAGGNSDVCVGYGSWCLEHPKEYPQWWKTLYEALNAPDLTQTRMNATTTTLLNHTFDDSGEEEEGRETQGASGEGTHHDPSRTRQRHKRSSHAVSHIIKEEDGTMLLLPRSWLLGAPFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH1</accession>
    <name>F9WFH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002143">
        <property type="protein sequence ID" value="CCD16042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14435" checksum="2803C4DFC1664475" modified="2011-10-19" version="1">MVCPFHPGRLCKKPSTLHTRSECVRRCVAIPSLSVVEVQTECHSTRPTLWAHTNLEEVALGFVENLHRYGRHTSGSHRRGDLASVSSATGSPVPALPGDSFGRSDAIFHTGPLSHRGYLVHIPVTPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFS2</accession>
    <name>F9WFS2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002183">
        <property type="protein sequence ID" value="CCD16150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11010"/>
    <dbReference type="OrthoDB" id="1706206at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23041" checksum="7A13E702C7C3A007" modified="2011-10-19" version="1" fragment="single">MKLVFTCPAEVEVELTVVEVVRASLEPLETARGFFRGLLHGARQYDAEDGHTLTTDTLQKAMRQVVFEDEGGGDLQTLAMRRWTTTLRYALDPETAMHEFLLAFLGELQTLDSFVENHRGADAFHQAARRIVFGEERPSERDLQTLAIQYVARSVLQSEDPEKKARELLGGVLHEARHLDREHHHHQGEEALLKAMEEISESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFW5</accession>
    <name>F9WFW5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_11440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658191at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="270"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="615" mass="68839" checksum="6A3F627106D6AC25" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ8</accession>
    <name>F9WFZ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002209">
        <property type="protein sequence ID" value="CCD16228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11760"/>
    <dbReference type="OrthoDB" id="1701031at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21129" checksum="937494DAA492D213" modified="2011-10-19" version="1">MRPPPPSRVLKYPASCNTQSVHRGVAISPYSSWLARITQLFQHVIPAPHTAPHTKACAHTQRASKSFGNAILLTTILPQSHGHFATSLVRKMVGHLPRGIISHERGKPQLHFLCCLDSKTPQTPGAAASETEGRRSFSVGCATFIKTLYTLRHVAPFYSHQHYFPSVDCGPSVSSSIPIQRAKETTHVLYGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG20</accession>
    <name>F9WG20_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002217">
        <property type="protein sequence ID" value="CCD16250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11980"/>
    <dbReference type="OMA" id="HRFMEAY"/>
    <dbReference type="OrthoDB" id="218476at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1418" mass="155360" checksum="78301C4041D6D0FE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG68</accession>
    <name>F9WG68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002237">
        <property type="protein sequence ID" value="CCD16302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12420"/>
    <dbReference type="OMA" id="ICHTSIE"/>
    <dbReference type="OrthoDB" id="96741at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
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    </feature>
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        <location>
            <begin position="375"/>
            <end position="408"/>
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    </feature>
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            <end position="554"/>
        </location>
    </feature>
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            <end position="583"/>
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        <location>
            <begin position="589"/>
            <end position="615"/>
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        </location>
    </feature>
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        <location>
            <begin position="905"/>
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        </location>
    </feature>
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            <begin position="939"/>
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        </location>
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            <begin position="967"/>
            <end position="985"/>
        </location>
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            <begin position="5"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1127" mass="124288" checksum="75AB9DBF308EE509" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG98</accession>
    <name>F9WG98_TRYCI</name>
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        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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    </evidence>
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            <dbReference type="EMBL" id="CCD16332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF8</accession>
    <name>F9WGF8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 498</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TCIL3000_0_13180</name>
    </gene>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002268">
        <property type="protein sequence ID" value="CCD16394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13180"/>
    <dbReference type="OrthoDB" id="1668320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="260"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="39993" checksum="D4A41E778E0A16D1" modified="2011-10-19" version="1">MSFLVFRHPARCKTVFATIISVFVIFSFPSPGAFQNCFCNNYFMSFLVFRHPARCKTVFATIISCVSFLVIRRPACCKTVLATIISVIRVISSYPSPGALQNCFSNNYLMLFRVIFSFPSPGALQNCFSNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFSNNYFVSFLVFHHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFRVIFSFPSPGALQNCFCNNYFSYSCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGI6</accession>
    <name>F9WGI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 506</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002277">
        <property type="protein sequence ID" value="CCD16422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13430"/>
    <dbReference type="OMA" id="VCEQHEE"/>
    <dbReference type="OrthoDB" id="1641032at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20400" checksum="4ED1B19F2A8155AC" modified="2011-10-19" version="1">MPLDDFVSRVAQRSSLSGNATPFTPSYLNQPNTLSNNREAGASGGIVRRSTGGAGAELAGLQNSKKKQRKTSKNANNGKVVSMKERKCGDDDDSGQKETLNTATSNTLQSALNVGKGISNEELRLLEGFLCDSDPNFTSGKGGARYEDGIFMNDDEQMQSEEEEWLLQQMMDIEIGGDKLLKLEEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGJ9</accession>
    <name>F9WGJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 508</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002279">
        <property type="protein sequence ID" value="CCD16436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13580"/>
    <dbReference type="OMA" id="HIMDEYS"/>
    <dbReference type="OrthoDB" id="214389at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="828" mass="91263" checksum="065A351705A07D07" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN1</accession>
    <name>F9WGN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002292">
        <property type="protein sequence ID" value="CCD16468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13880"/>
    <dbReference type="OrthoDB" id="1715149at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18567" checksum="71389F723DE52AC7" modified="2011-10-19" version="1">MIPQSTPWVIGLQLQNNTPIIFSLFYYAFTARAPPSPRLSSGTSPHSMEPLIGLWAFRKNFREIAFSRTLRPYLAIMRRRIGAWKNSDIRATPPFSRLFWGSIPLWGMWATRHSQVGIIPSEMLPATHAKAFSSLLQLVHSALFSLKPFSAEHSSLWVADYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS9</accession>
    <name>F9WGS9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002316">
        <property type="protein sequence ID" value="CCD16516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1171699at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14525" checksum="22E0FE706C9F5492" modified="2011-10-19" version="1">MCRPLSPFLDNLFTEFVQVGADERSLQESFITVVRSLLHFEGHWLGLPQSEVLLIRVTEDGGAGTAVSNASSSLDTPPRRWSTWLGGGEGSKSDVSPVGWRTIDICTSGCSDSVSLNSEVINSVQHLFTRAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH32</accession>
    <name>F9WH32_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TCIL3000_11_12770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_15300</name>
        <name evidence="2" type="ORF">TCIL3000_11_12770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002367">
        <property type="protein sequence ID" value="CCD16621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.12770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15300"/>
    <dbReference type="OMA" id="MEDDIVR"/>
    <dbReference type="OrthoDB" id="1489616at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC95781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="202" mass="23437" checksum="28649EA734AD5E2B" modified="2011-10-19" version="1">MLRPVAQPGGTALVFSAVGATQRRWLKASTTPKTADEQTVPVLHSLYRRLRKEGEERKMLEDALSVHSLETNIRVGLRLLQCHTRLINTNRQLKELPVWRVVRCVSLGITRRYYALQIFLIRLRLRSAAAISNVLVYMLLLVVCFMLYEIYHVCRIGVTRAEDRYRALAIPIVQTFDALEDAVRRRKEAHLKQMEDDVVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH62</accession>
    <name>F9WH62_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 600</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002381">
        <property type="protein sequence ID" value="CCD16651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15590"/>
    <dbReference type="OrthoDB" id="1669212at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="437" mass="45688" checksum="0F088133F119D2E1" modified="2011-10-19" version="1" fragment="single">MSASPAVSPSLVQRGVERPMSGASMFFPRECEACLSRSQMSASPAVSPSLVQRGVERPMSGVSMTTRGECEACLSRSQVSASPAVSPSLVQRGVERPMSGASMTTSGEREACLSRSQVSASPAVSPSLVQRGVERPMSGVSVVLPEECEACLSRSQMSASPAVSPSLVQRGVERPMSGVSVVLPEECEACLSRSQMSASPAVSPSLVQRGVERPMSDVSVVSGGSDAVCSRLKGIGLSRSGSSVCASSRVLGECGKIDCAVFDSCGVGECTGGKCDKCCDVGVTKSSVDGLRFLEYSLCSAVGSGYFDSFLLDERSDWYWPARKVVKRGSVRDDVVCFNASLREGTNNKCFASSVPPVVNDCGVEDASVCSGVGGCSGVRLPKVNSGDVSATVSFFERRDVLPSCDAPFGDNGDPKERFFETPKGALLEPSARFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA2</accession>
    <name>F9WHA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002401">
        <property type="protein sequence ID" value="CCD16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15980"/>
    <dbReference type="OrthoDB" id="125522at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="22892" checksum="2F571B06DC73A48E" modified="2011-10-19" version="1">MDQQGRSRGRRQGRRNKREPTTLSSPKTIPWSMEKDVVEVLLEGIMSPDRINLYWFLKPVCSVVQEQYAGFTLCDFVRNPRHCIPEVSVCDEVWRYLPHLLWKWRHCATPLVRHVGPPDVWRPAQWSSWQKYIDLDDTPLEAIDEDVWRRCRRPPPPPYRPYQGVLLIEAMPSFIQVPYSTMGYLVPIPQPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC5</accession>
    <name>F9WHC5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_16230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16230"/>
    <dbReference type="OrthoDB" id="1663190at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395055" evidence="4">
        <location>
            <begin position="22"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="91"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="427" mass="46510" checksum="3420E0E8E0C7A2EA" modified="2011-10-19" version="1">MACSLNVIAVLSFSILGVASGQKELEIDKDENIEAFALLCRIYNVAKNPPINHVDLEEPHKIVEEINSINASFSEEKVANETEQMGNIVVAQHSTTTREAALGQLSLNQITQRAHKILEDIRKINVTKEIEKAKAEFHQVIFGDDGNESNLCHATVKGMDNRSDVCGKPGQLSKGNGAGKNLVVDFFCLCAQRTDSSEGAKQACGFHVGRIDKHYGWSEQGPWGSSTMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLKTGGVYRWGSGAKIEGSERKAGMLGTGVGAKEGAVSGPVCDGKKGNGRTSPSTGGVCVYYGQESDSWEEKILWLKKFKTALGTADALNRQTATVQRDIKRLHMLLHRAEEIYETAKVIPEVKNSVGLPEAFSNATGNLTAHNATRTRSYSHSVNHYLITLCAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW1</accession>
    <name>F9WHW1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002490">
        <property type="protein sequence ID" value="CCD16906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17890"/>
    <dbReference type="OrthoDB" id="1717912at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20428" checksum="5FF714800C880F44" modified="2011-10-19" version="1">MLRCTQFNSNLTNMPAVDWRYKIETVVLLRRCGERTGGTIETDNFKVSVVPPDTIVDIITITTTKVELFLTLMSAIMPSSVEKKESRQKLSCGNTSKENGGIDVGSSIQKLKCTKRKGSLKAVSCANVNSFCLTKRAICRHAHCVHYIGQPPSQKPRPVIAFGLRFSLLPLLSIHHFPFPLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHZ1</accession>
    <name>F9WHZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 709</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_18180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002502">
        <property type="protein sequence ID" value="CCD16936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18180"/>
    <dbReference type="OMA" id="LWVLCIC"/>
    <dbReference type="OrthoDB" id="458757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="590" mass="65391" checksum="231246EFC9D3E019" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII8</accession>
    <name>F9WII8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 800</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002603">
        <property type="protein sequence ID" value="CCD17136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19830"/>
    <dbReference type="OMA" id="SGMQPER"/>
    <dbReference type="OrthoDB" id="105185at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1128"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="850"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1428"/>
            <end position="1442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1535" mass="173864" checksum="0E38454FE96A4815" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIN6</accession>
    <name>F9WIN6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002620">
        <property type="protein sequence ID" value="CCD17184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="109" mass="12200" checksum="107AE6409AAE7503" modified="2011-10-19" version="1">MFWWCRFGREIQLPTSLPFHGVGWLGRRNPRAPGVLGRHPRHVVNWFSSRPCGHLFRHVLRPHGLCDITVFETLLPMENKGRGKGSSGLNPGTTLLSSQLSDSSFPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ2</accession>
    <name>F9WIQ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 820</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002625">
        <property type="protein sequence ID" value="CCD17200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20370"/>
    <dbReference type="OMA" id="KLAGTHC"/>
    <dbReference type="OrthoDB" id="1589300at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="40841" checksum="C66D5273D93A83C6" modified="2011-10-19" version="1">MVSGSSLCDSTSAHAATWLRKKIMFSSVLYDLTVLRLLHCVQMYTTHLPGQLQTSDAVQNLVKYYPNPPRESVNMAAMYGLDESRLRRIRRLPPSREGVDVGGSPSSMQALIPEEGDLLTCEFTGEKYQYSGLVLWSSSRLLLLICTVRDATLCERQHDSYLSRLALRAKQSLLNLLTEKALQSQLEFAWERFRKNAFAGDGAEDTEEGDALHCLRVLQARSVKFSLHNFMEPFLHINVNWRDLLSNARRNLWYSYEPDYALHLINVHGVQTSAERPDEVNDFQEGLILTLGACGLGEEYLVAVEFDSHRKCDVIKTAALYRHTNDRSSAHTAMTDRELQLVECVLRLLSSALWNHEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIV6</accession>
    <name>F9WIV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389191" evidence="1">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13855" checksum="239234631AB38224" modified="2011-10-19" version="1">MMLMWTFWPFGLEASVHSGAGSLAKALRTSLSSLKGSWVKLSVKSEAAKPLYLQVVRYLCQASKKQGTIPAIPGLSLQADHPDHDRLMTRSWKKLLGMHAKGGMTCILPILLLHNFREGSVARVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIX5</accession>
    <name>F9WIX5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002652">
        <property type="protein sequence ID" value="CCD17274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21070"/>
    <dbReference type="OrthoDB" id="1745121at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394808" evidence="1">
        <location>
            <begin position="18"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12823" checksum="83D46D2D96E22483" modified="2011-10-19" version="1">MVSALFPFIAPPAICWCAFTLGCTFRHNVVGSFFPLTSNVLTGACFIHTDSPSKQTDKYPSSSSKCRPYGSHISVPFTRAHPFRYAPHSQLPVKLLLPMDGSAMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ77</accession>
    <name>F9WJ77_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_22040</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002693">
        <property type="protein sequence ID" value="CCD17381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22040"/>
    <dbReference type="OMA" id="YFYQRAA"/>
    <dbReference type="OrthoDB" id="378349at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="5"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="507"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="624" mass="69233" checksum="F37DD70A0B958E4C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB7</accession>
    <name>F9WJB7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002707">
        <property type="protein sequence ID" value="CCD17421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="DITDITY"/>
    <dbReference type="OrthoDB" id="964931at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="PTHR21231:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13384" checksum="4D178E0C658978FB" modified="2011-10-19" version="1">MVCFECPFMTILTKCDLLPPDMRENELEKWCYCNSDHLNLKPLPGRWQQMVRTMASIIHDFNVVTFCPMDITDITYVSNVCSQIDEVLQVVDEAEVNDRDPPENPVSGEGALDGGASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJN3</accession>
    <name>F9WJN3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23540a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002748">
        <property type="protein sequence ID" value="CCD17540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23540a"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="22" mass="2893" checksum="E0258037B0E57412" modified="2011-10-19" version="1" fragment="single">LHRRFFIFVCMWCNMQICMKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJS6</accession>
    <name>F9WJS6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 945</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_23960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002763">
        <property type="protein sequence ID" value="CCD17584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23960"/>
    <dbReference type="OMA" id="MRECERC"/>
    <dbReference type="OrthoDB" id="58737at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="941"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1254" mass="139067" checksum="AEF0E6CC5E9EDCA5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJS9</accession>
    <name>F9WJS9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_02550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002764">
        <property type="protein sequence ID" value="CCD17587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02550"/>
    <dbReference type="OrthoDB" id="1671234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389233" evidence="5">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="38983" checksum="7C99A23A69B50C7C" modified="2011-10-19" version="1">MIMKFWIIVFLAVMEIVGADNVVSEETKDHNKEAHKALCDLMKAAANKWREVEKRVPTDPLRNALVTTLFGYGTVGTLETLRSVLPSDYDDVEGTDSSRSNWCGQPLNGDYQNNYPRWSGHSAPHDMVCLCTLGNNTWPLVGSEKDKLCGQNKNSLGGDNEWWSGTNNTKKRDAIEKTWKVTVNPCLSGSSPEKDLKEALKKFTGKIVHTWDAKYDENHYVLGQNGTDYISKPCDGSPKDGLCVKYYNSTKPFPWWVDLEKALIEDAEIQKQRAEEERRKQQDRERKTDEPHAEALTSGPQTNNQTEQHRNANLTEKLRKYNIKSGTPISRPSSWLLRAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK40</accession>
    <name>F9WK40_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 984</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_24870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002807">
        <property type="protein sequence ID" value="CCD17701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24870"/>
    <dbReference type="OMA" id="MRVTIMD"/>
    <dbReference type="OrthoDB" id="161922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026829">
        <property type="entry name" value="Mon2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PTHR10663:SF333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mon2_C" evidence="2">
        <location>
            <begin position="1363"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2075"/>
            <end position="2114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2170"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2075"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2173"/>
            <end position="2187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2240" mass="243691" checksum="14C8FE69141B802C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W354</accession>
    <name>F9W354_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1002</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000354">
        <property type="protein sequence ID" value="CCD11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25350"/>
    <dbReference type="OMA" id="ECFQKVE"/>
    <dbReference type="OrthoDB" id="1665370at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="429" mass="44532" checksum="14A7376D0F720348" modified="2011-10-19" version="1" fragment="single">MDVASPKQRDSLVVPPALETSGVAAPKQRDSLVVPPALETSGVAAPKQRDSLVVPPALETSGVAAPKQRDSLVVPPALEAMDVAAPKQRDSLVVPPALEAMDVASPKQRDSLVVPPALEAMDVASPKQRDSLVVPPALEAMDVAAPKQRDSLVVPPALEAMDVASPKQRDSLVVPPAPETSDVAAPKQRDSLVVPPALEAMDVASPKQRDSLVVPPAPETSDVAAPKQRDSLVVPPAPETSHVAAPKQRDSLVVPPAPETSHVAAPKQRDSLVVPPAPETSDVAAPKQRDSLIVPPALEASDVTAPKQRDSLVVPPALEASDVAAPKQRDSLVVPPAPETSDVAAPKQRDSLVVPPALETSDVASPKQRDSLVVPPAPETSHVAAPKQRDSLVVPPAPETSDVAAPKQRDSLVVPPAPETSHVAAPKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W361</accession>
    <name>F9W361_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000356">
        <property type="protein sequence ID" value="CCD11569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25420"/>
    <dbReference type="OrthoDB" id="1238370at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30083" checksum="A1DDE8E2C10ED087" modified="2011-10-19" version="1">MPITDFALDPELCSDKGCSVDAAGPTAKFSAVDCASDFSEGTLQAQIRSVVEAVLNESHFPWRAAEVAEQRKEQRRALKAFKQECRQRCTALEEKLRFALEAIESTGSSLAELRAGCFMAEAARSAAAETGCLASSPREQLFAQPSTRMNSPFAKATTKGASADSEQHLMDLVLRRTKRFTEACEERCVQRVALEITQPLAEHVRRLISAHQSMVDTVVESRCEQLEGRITRTLQQQQMQLKELGSRLGGLRSDVQSALRDFSEKLDVACPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W378</accession>
    <name>F9W378_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000368">
        <property type="protein sequence ID" value="CCD11586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1248045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13771" checksum="1CC733791720CF0A" modified="2011-10-19" version="1">MVPSEVERSLIFSLVVQKDGALSFRLDESLLKLREPLHCFADMGTRGTFKRPVTVVICGEEEFPKKSKEQFLKHFPKTRFVLFDGDRSAGINGLFTQSEVFGRTLLDAMELLGDVTTNESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W395</accession>
    <name>F9W395_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000376">
        <property type="protein sequence ID" value="CCD11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25740"/>
    <dbReference type="OrthoDB" id="1691241at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="26253" checksum="159006E0EEFB4494" modified="2011-10-19" version="1">MEAEKGRYFVCARCGSAYKHNGTRLRGIRAHATRKMKDEFVVFTLTMHHTLQCWHGPMKCEREQCLTTMHLQAKHSQPKEGVEHNALKAMRQESAAYLLVCQTLFPLRQKHGLECLKEEQVYHSEPLARSLADLFKLKGFHDPTSYFPVEKPNQAVRRGRSPDLLEVPSPSAQFLVVRVVSHKDVKNAFTLQAVCFTILLEEARTGPALRSVFPAGLRNAENSRASSGARAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D1</accession>
    <name>F9W3D1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1039</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000395">
        <property type="protein sequence ID" value="CCD11642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26070"/>
    <dbReference type="OMA" id="RNFWIST"/>
    <dbReference type="OrthoDB" id="1611231at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="24257" checksum="E430F0822748FDB5" modified="2011-10-19" version="1">MSVAHCQRITAAAAYLLDSRGFIKDEVTLRQITYFACMHRFASAVWLSTQLADDLGLTLRYMQSPINVWNPLMGESFVHVTTASALMQKALRHHPVDVSHIQTQDNVLVLSVASSPDGSPRWLAAPDHIRHHFVAPDVKYNPRSPVMSPRTATCYRNFWISTVIAAYLGIDGEGPVITRVPSCLTSLLNADQLYPSSLLQDAEFQCFLETQPNCSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D6</accession>
    <name>F9W3D6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_26120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000397">
        <property type="protein sequence ID" value="CCD11647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26120"/>
    <dbReference type="OMA" id="MAPYSSK"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="17467" checksum="90F3AA52640F10CF" modified="2011-10-19" version="1" fragment="single">MFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFMRGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALELFEELMENKDDYKKFYEQFSKNVKLGIHEDSANRKKLMELLRFHSSESGEEMTTLKDYVTRMKEGQKCIYYVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G6</accession>
    <name>F9W3G6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000408">
        <property type="protein sequence ID" value="CCD11683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16867" checksum="3FC3D24420FF145D" modified="2011-10-19" version="1">MRWEKSPGMETGKPPFFEFAIKDPYGLDNIGRNLDIEAAVYVKSAHSEALKTLLQEYADPEFAVNIITQSPPKPIRRNRTLASRGISSATCSPDQLEARHILKKVAFHERRRAMERFGERTARHTEEQRVVSSVAKDVLGWIKCDKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Q1</accession>
    <name>F9W3Q1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1089</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000451">
        <property type="protein sequence ID" value="CCD11774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27190"/>
    <dbReference type="OrthoDB" id="1710304at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19723" checksum="EF1F9A93CB78BDED" modified="2011-10-19" version="1">MVKRWLPQTTGNGQTLLHSGELSRSCVVRPLFGYVPLNFSNGYRSPATVTPNKALGSRSFLERGPPAQWASLCSNSFFLDQAQDSLWDRLLPPADLQTWGRVRCIPRGTQLQYCGAVEFCLWFPPKLLPACVCVGVVDFGTLQKLKAEYFDFRLQVYTKLMPSWCQLFLLLLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W474</accession>
    <name>F9W474_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000525">
        <property type="protein sequence ID" value="CCD11962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28950"/>
    <dbReference type="OMA" id="ATGGCPC"/>
    <dbReference type="OrthoDB" id="1204142at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="31149" checksum="DB4696343BAD390B" modified="2011-10-19" version="1">MDTTDAVATMPKKPKSKIDSCPQQSKRHATQSARHDKYHRCDCYGHTLGLPNYKALAQPRTNNYYNAVGGCPCIPRSVARPGSWRQKRDQIRSASNYRQTWCAKGHPNATCCVHAGEAYGWLPGPHGVLSKNCAASGLCDTFGNMEFKRPPRRGDIDSDVSSVNTQKLEGLESLILKEHGERRRIEMDVDELEEIKKKGTEEDYKLDFHNEKSRKLAMAATESQLKGLLREVRGIVDRPLNQTNIDILRGIIDRQERLMKLRAAKATEDFPPIIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A2</accession>
    <name>F9W4A2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000533">
        <property type="protein sequence ID" value="CCD11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29160"/>
    <dbReference type="OrthoDB" id="1729781at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16950" checksum="5668D3C4DF39E643" modified="2011-10-19" version="1">MHCGETLLPCAFHWAMRTLGCVLHREGDHHRLVLHLSCGMRTCSAQAGAIVLVCAAASCTHKVSSFLRFHVPAYSSTFPRPLPIHIHLCLLHTLPVSVSYSFCSFSLYGEVGTTALATASRRGLDVSLARDGSTFCSDTLCHLRGTCFWMVVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4B6</accession>
    <name>F9W4B6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000538">
        <property type="protein sequence ID" value="CCD12005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29300"/>
    <dbReference type="OrthoDB" id="1668438at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="43785" checksum="2B51D2C481DE88C3" modified="2011-10-19" version="1">MNMAEYFVWWIMVGLFMTWFPVSSESSFYPKAIPTEAGGAICTLSRKLKDVIHWTVGKLSELRKTREVYTSKFLDWQLHFHGSPECELNESIFEECRVVLKEVNEEIGGLPAKAILAGALAARSAGRLDEFITVFVNAQKDSFIDGVNYCLGGGGNPARRRDLLDCFPDEEKLEMGENNLAKIPESMTNEKELDLTAALENVKHSAVETYFSRIHWLDIHADCNLIKGKKEGILDGALNGPLWWGGGILTIGKGFNGEIKSSQFIAGEIANDSKGSNSDNKAFWIKSPHTIPHLKKTLAAFQAFKDAAARITRKFSEIEKIEKRIETCLSNETMEDGHTQSCLKSAVKLNAELQVANALLARYHKEKGPLPSGSALILHQSVVNVWYLFAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J6</accession>
    <name>F9W4J6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transmembrane protein 107</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_30050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000564">
        <property type="protein sequence ID" value="CCD12090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30050"/>
    <dbReference type="OMA" id="SWQATAH"/>
    <dbReference type="OrthoDB" id="1298018at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029248">
        <property type="entry name" value="TMEM107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14995">
        <property type="entry name" value="TMEM107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18190" checksum="2483FF7CC1160E8D" modified="2011-10-19" version="1">MYFSNSFSRTHSPGRCFTLTRRFNVAVLVPLRLFAASLHLTALICVADASAEFMRVSSSGTEQGGSNGKIPKDSLILCLALSFILLFFNLWGIISGRTLRFGFMNFMHVCTHTSAAILLGLAWYTSAHTKQLWHVFYALSLSPALLEVFALFLSYYRGLDVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K9</accession>
    <name>F9W4K9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 1195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_30180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000569">
        <property type="protein sequence ID" value="CCD12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30180"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37964" checksum="43EEE870AB9E8570" modified="2011-10-19" version="1">MASDTSFATKTYVCVTCFILDVCAYWAVETRFLAPIFMASHYKYITGNEHAEPSSVLFWLNIFTFYNLILFAARALAERPELERLVRGWGLRLRFTLSIVLILAELALIFFLPVLSMSPPYAIVSLCFTTILGTIGKQFLGRTTHTLWDFLLTEKAGGVMRFTAFLVAIVHATLCIIVVVPGTTGESRENTLSLHTVVYAVVLVIALVMVLSLSLIRCTREGFRSAQRAAQKGRVEGINHLIERVGKTRKTLESIRVRLHAQSDPILRNEVQKEHQQAKRETVEAQEDIRRRLKDEASISALSRLAEFEAEWARPLPPEASSDGGNRDVAQSPQAPDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4N7</accession>
    <name>F9W4N7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000581">
        <property type="protein sequence ID" value="CCD12131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30450"/>
    <dbReference type="OrthoDB" id="1728267at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15725" checksum="A57B21BA56E9A60F" modified="2011-10-19" version="1">MIYFSFYSNQSGKFKPFQYKTEPLMVSALIPFIAPAAICWCAFTLGCTFRYNVVGSFFPLTSNVLTGACFILTDSPSKQTDKYPSSSNKCRPHGSHISVPFTRAHPFRYAPHSQLPVKLLLPMGASLRAVNAKWCMALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z3</accession>
    <name>F9W4Z3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_31410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="8"/>
    <dbReference type="EMBL" id="CAEQ01000633">
        <property type="protein sequence ID" value="CCD12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31410"/>
    <dbReference type="OMA" id="VLQCKYI"/>
    <dbReference type="OrthoDB" id="871204at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="PTHR45780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="10">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CTP_transf_like" evidence="10">
        <location>
            <begin position="219"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="384" mass="43214" checksum="DF11D72D48D0CC17" modified="2011-10-19" version="1">MNGSTSKVCLNADCPDDPYPLYATSPLPPKRPGTTRVWVDGCFDMLHFGHANALRQAKSLGDELFVGCHSDAEIILHKGLPVMHEEERYEALRGCKWVDFVVEGYPYVTRVEDMMRFGVDYVVHGDDISVDLEGRNSYQAIIDAGMFKVVKRTESISTTDLVSRMLRAAPNKPAYAADKTLLDEEIAKHPPTRYLTTSRKIAQFSNNRPPPRDGKIVYVQGSFDLFHVGHVQFLKKVRALGDYLVVGLYDDQTIRGEKGELFPIMSLNERVLGVLSCRHVDEVIFGVPGSVTREMITSLGIRVVACGSMVSSPIRTRDCDALTVPRELGILQEIESTSSLSTNDIIERVMKNWTTLVERQSKKRLKDRLVESQKPELYRNVTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W516</accession>
    <name>F9W516_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000644">
        <property type="protein sequence ID" value="CCD12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31630"/>
    <dbReference type="OrthoDB" id="1667526at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="415" mass="47003" checksum="E61DE38F874D2899" modified="2011-10-19" version="1">MVVCLFLCEVMCFSSFSIFLIIVGIWDTRMMVRAMWAMGFAMVMFMDDVRVYSYPDGTVFNDVEYKALCEVFKASADLWDASKSAGKVPSNVLKSALSQALFGSTGGGDLESLKDELPKEYRDPGQRKYRCGYCDYKTDTYAGKSITHDLMCLCTPGKDAEPFYGHYWWLFGYYYKENGFKLCGTLKEEMGVDRSHGWYEEQKKRGTKGLEKAWKTVIMGCLKKWKNSSKTVSQDVTEKVKKLSMAMQNFTKALRRVNGLDKLGGFDEHNEADGTTERNLHVRYGNCEKKRKPWWKRLNETLNGKTPEDVLVDPSVSAQPTGAIDEPEEDGEFLEESHGESFESESPATQTSDSLQKNNGNSTHIPTTNSSNNRTMGPLNNTDSRNSTFPRIEYLRSNTAKTPPCSWLIGAPFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W554</accession>
    <name>F9W554_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1277</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000660">
        <property type="protein sequence ID" value="CCD12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31950"/>
    <dbReference type="OMA" id="PRTRKEC"/>
    <dbReference type="OrthoDB" id="1392446at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="53"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="251" mass="28404" checksum="8EBCB3A898A6DA62" modified="2011-10-19" version="1">MVECWKSGANFSGESSSIFLEEVDKRRSSTLHKVITNVLCEANLFPYPSQSSDKLSSVDLYVAAFSALPERGFTSQTFPNWEEWNDSSAKNFLVGVVGVAWTSLSPGCVVEGYLHVVWVRPEYRRRRIVQQLLRRTLSITEGGPLSHRVIRWRLHTMKSSAATNEYLLATLRNGVARAASSKATDDGAFDAADGNAAYEEELRDVELLFSAVKRMYKKFGFCVRRYIYKYYAGKADAVEMIKNIPRTRKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W585</accession>
    <name>F9W585_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1289</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000674">
        <property type="protein sequence ID" value="CCD12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32250"/>
    <dbReference type="OMA" id="TRAEARC"/>
    <dbReference type="OrthoDB" id="1138688at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="409" mass="44919" checksum="7E15637B27650B41" modified="2011-10-19" version="1">MFTSTTAPHTFQPPAVRVPLLETPTTMLSSTCSVWMKPQGPNASESTLRDHYQSADTGGIGGSFFCDSASLIDNSKRMDRVDELLRSVHKHCRGVPEERNGVERMSPSPARMQTKTRSTRSTSRSDPQSRSGDEKGRSPSPGNHLQGGPPARPGWNRRTPVPRARPVVSDPRTEPRRITRSSSSEDHNHLRQERFRGSNSARPALSAPKAVNKISTVTVVSSRAQPSQRPKPNASEPSVVVVLPQRKQGSSVLDGKRAEELLTDDPRFNFMHASLQEAQERATRAEARCEELEVTVHTLQLQHNESTRRLEERQAQLNAQVQYLLQWVRQLEGAAVKGEVVLGGIRETEGSDPLPGTQCGYKGREDTFVPSCGTDNATGAGLLRQEVGPRSTSLRVPPNPPICLKLQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W593</accession>
    <name>F9W593_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000682">
        <property type="protein sequence ID" value="CCD12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32330"/>
    <dbReference type="OMA" id="CRSLWEP"/>
    <dbReference type="OrthoDB" id="1258478at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="454" mass="51399" checksum="6AC030170A626FCB" modified="2011-10-19" version="1">MVDVVSIAQSILDCADDAALQILSLAPELPPVTVDTPVTEARRSYIRLAGMLHPDKLKGKLEKATEVFQKLVRAFEKVADPKYRKALMVQQAKEKKKNKGSAAAREHKAAGTKQKVETKTLLDTDDTRTRKRTNKGLSVNRKTKESVHDDFIVHDSEDDYEDVEEEDFGNNDNDSEFDKYFFQSTVPPPVSSNRAMIGTPRVGGIYIRTVVQCPQCRTTWEPDSKQQYSLFMGPAGKKIHCETCLCRFGCATAFHACPHCKCAFDYDATMYDSQIDCTRCKKVFGFPYYPVNQNLIDLVRLEEWRERVERESALERTQRANRRHREASEEQNELHTLVGTCIVEEKCPLCKAPVTSRHRRHVEGCMKKSPADRAASGRDLLPREDKAKKTPRTREPKAVVTVKSAVNPKRTKASKTITTNKSAKTVRKKRARSESTSSESEEEFFSESSSSYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W594</accession>
    <name>F9W594_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000683">
        <property type="protein sequence ID" value="CCD12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13617" checksum="CB38FC2FCE01B612" modified="2011-10-19" version="1">MYSSTGKSGGTATKAISTKPKRHRRCCLPRCDPVRGTPLRKREKERECVQPGSVEHDKGPPTCEKEAWCTNCTLRQRVWFPYGTKIATPLRNTSHSTLERVPRAGDPTLLLPGAQKNGGGSTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E9</accession>
    <name>F9W5E9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000707">
        <property type="protein sequence ID" value="CCD12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32810"/>
    <dbReference type="OrthoDB" id="535356at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019176">
        <property type="entry name" value="Cytochrome_B561-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21780">
        <property type="entry name" value="PTHR21780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="327" mass="35787" checksum="916036789AF4E154" modified="2011-10-19" version="1">MGAAAATFSGGNGIGSASSSGGIRVQYGSTGEREERSASGKRSVNNIWGSVGVVDPERSLGSVRKWLSHLCQTLVEEVSATDRWFAERQLISFDCSHSLEEVIPMPSPSAPSRVGFGAPQTQAAPPQPFRKADALMEERRKIASQGQNVQNCDVTMHLDQRLQLETKLDTNTTFPPATPTSVTEQHAQRSYVLERIRTFASQTSLASYHHSRGDKHSWRNGFPTDAHLLIHIVRTCVPGFSDYVKFPHQSSNSQHDVTLVVGDMGEPYFYVRYRSGCTDETFSTRTGPNSLFEALVLFAAVLRTRHRGSYGGIGGLLDLTLSGLLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W617</accession>
    <name>F9W617_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000811">
        <property type="protein sequence ID" value="CCD12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34820"/>
    <dbReference type="OMA" id="YAMGIGM"/>
    <dbReference type="OrthoDB" id="826593at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43162" checksum="14C6F9A773055056" modified="2011-10-19" version="1">MYAVKPWGKVILVGSGVEMYALGIGMRWRESNVLLVEKQADPSYELTNRRRCVLTSQTVKILKDLGCTTAKVEGILQRPRGWRFVSPNLEIMREGSTFPGCADGEATYQCTEGVLLRTLRTEFLRFGGDISWGTEAFDAFESGDGSGTWSLRKMYGLETEAEAIITTANETSFTPLLIADDPDRLAVLFDEETGVLPGEGKLAEKIFGTSDVVIVIGSKIVVHMWYIDGVITWRAIRRAQKDVQGIDTPDFHPFLREVFQGSTNKLSRVRIIPATTPAIKDSAAHAKVSVLGDGLLPIDPFEWRGDRARCGIEEASVLCRAFYGKKYHRGNVPRLLREVEQDALARRAAALARDLRDAEHFLSSQPVIDAMHHEYVQQNEILSLTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6B2</accession>
    <name>F9W6B2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000845">
        <property type="protein sequence ID" value="CCD12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14539" checksum="7D1AAB56EF4E6A0B" modified="2011-10-19" version="1">MGSGGGLAELSLGYKELLIHNFHVALRQPLLLEVIQISKRLPGVTQFAFALIASTYVVEVDGIWDKGQYTIRVQNADDIAAFQVLFPRIHYGGGNVFHPLEEAVVRAVMIEEVFLTVPAEDWICSHMMSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D3</accession>
    <name>F9W6D3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03610</name>
        <name evidence="1" type="ORF">TCIL3000_6_30</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575319">
        <property type="protein sequence ID" value="CCC90777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000850">
        <property type="protein sequence ID" value="CCD12738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="130178at199999999"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC90777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16038" checksum="5964585D8587D32F" modified="2011-10-19" version="1">MHGTIEVPIKPHEATVLQLAERACLNTAVPGGHKTETPEKEERVHTMGRVQRFNGYGYQLWTDGSVTLDVSSGAEALVCPLNGKREKVTLCGGNLDSSFRVECVAVEAGLHRLLRIIEMNESRKTRVVAFTGSLSLLVALKQELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N9</accession>
    <name>F9W6N9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000901">
        <property type="protein sequence ID" value="CCD12846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36870"/>
    <dbReference type="OMA" id="PSNEACQ"/>
    <dbReference type="OrthoDB" id="1158228at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="35501" checksum="F479D7D25139C17B" modified="2011-10-19" version="1">MEGILWQEKFMEEYKRGQRTQDGTEATNYKKALMSKFRGKRGTDSNKASSDDVKAINYHTTGMGHRSSVPAPTVPESTACDQTPSVYSGRPIEEPITNHDNVTKEEVTQPALEEGIQEHQGVAVGKTAEDMGEEAPQGDAAEAEPSNEAGQSQAEEAPQGDVAEAEPSNEAGQSQAEEAPQGDVAEAEPSNEAGQSQAEEAPQGDADEAEPSNEACQSQAEEAPQGDAAEAEPSNEACQSQAEEAPQGDVAEAEPSNEAGQSQAEXAPQGDVAEAEPSNEAGQSQAEEAPQGDAAEAEPSNEAGQSQAEDAPQGDAAEAEPSNEAGQSQAEDAPQGDVAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R2</accession>
    <name>F9W6R2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000919">
        <property type="protein sequence ID" value="CCD12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37080"/>
    <dbReference type="OMA" id="FNGRMRI"/>
    <dbReference type="OrthoDB" id="483501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="609" mass="69139" checksum="F31F6F74AEB85718" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R3</accession>
    <name>F9W6R3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000919">
        <property type="protein sequence ID" value="CCD12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37090"/>
    <dbReference type="OMA" id="FTARRTV"/>
    <dbReference type="OrthoDB" id="394189at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="46484" checksum="364D4F3984574251" modified="2011-10-19" version="1">MAPLGDAWDSLPLQADGNVVFASFITLLSPNGDGVKRTGPPTSVVSGERDDAIVCVLASRDVVFFDFMGEGGIPREVQRFCGPPPLCVSRFMRTPVSSSAFCASLLPLDVSYMCRVQVASGGVPSSGAGAGSAGPVYLRGVVGTSDGRVDVFSEHGYVFGFVACDGPVVAVRPIYNVSVHCGENPAPPDEGGDQGRPLELATANLGFVTASADGVVYVWQRDSTMLKPTVLDRSAFLSRTVCWQAVQPSSRDWLLNGAATPRTPFVLYTTPGLASELRVRSAVTFDDVESRVQLPGGFATRTTAIASDEKAALVARGRNVYQVTFADASCVDVFEADSNVVGLHMSCGGGDILAAACDVRGTVYLLSKTPVCVCGRYRAAGGGPVQSVSLHAASRLLTIVGGNGKAEVVMAPENPDNAGAAPATTVLQCLVSLRRRDGDGAAAPGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6S8</accession>
    <name>F9W6S8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000928">
        <property type="protein sequence ID" value="CCD12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03700"/>
    <dbReference type="OMA" id="VFTQFIF"/>
    <dbReference type="OrthoDB" id="1643834at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="20807" checksum="CB1D8706E85CDC0C" modified="2011-10-19" version="1">MMFTGFYIFYIYILYNFICFFFAFGINFLIYYLEFFTFLLFYIFFDFVSFSNYIYNYFGLLVNFNIIFCAYLFCLFYFIIYFLFCFIFFVIRCLFVVIVDFLFFNFDIFLSILLCDIVYLDFISLLLVYFSFIFNFIYGFFIFILILGLVFLLLFFVINLFFGFTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y8</accession>
    <name>F9W6Y8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoacyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_37660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01000949">
        <property type="protein sequence ID" value="CCD12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37660"/>
    <dbReference type="OMA" id="FHNNSEI"/>
    <dbReference type="OrthoDB" id="1333903at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="243" mass="26051" checksum="0DCB712A7D296BC6" modified="2011-10-19" version="1">MLGIIGVDSGTLLLCTVGLVIGLLVPLAVLGVLGQRCQAANQRLATSRRRKAVEFLEKLRKRKGEPSSAPFHNNSEIPEANGAEISPESDSGEEEDVIDSSDKTEFERIEELRLKMILVIRSDGKKIPAQTVATRAADAAMSLVEAVQSTAAAEDWKRWYLWWNMVGCTKITLKSSSVEELQRLLAEAHGRGLPCCSGYSDSGVVSFPTAGPGSDESELTVVAVGPVPSDIVNPLTGSLKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W741</accession>
    <name>F9W741_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1562</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000977">
        <property type="protein sequence ID" value="CCD13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38180"/>
    <dbReference type="OrthoDB" id="1671887at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="44784" checksum="94772EADDB20676F" modified="2011-10-19" version="1">MCSSHRRKVAWDSSLDYTHVDERRLPAASRAASLETQLSQYLYPFLDRSGSGNSKGGDVGHSAAAGARKSGSLKMKKKVKQATPDATELPRPSDRPSPNFDHHREECPPQTGSPANHDNETNEDDNMQPTRPEACEASTVSHFRKSSITSQLQYGTCGGDDDLQHCAQLLLERCNGSSTRPPLGFSYKCVDTGRYMPHLMVGSLPPSRGSRASRKGKHYTALVSASHNRISISPGSRASERTGTTSSGLKKPRNAGQPEPATEKLTPISPSQGLEEEDTAVPHSAAGQSSGSSDTTSTNTLYVCEAEEGALDTKQTLPSGPPDVKAEEPATPTEAERSGTTCESGMADAKSGAREEPVIRETGERAGDPHEETSEKTEEKVDEEKDPNEELSEAEESGEECVTDGEITESAPEEVATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7F4</accession>
    <name>F9W7F4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001021">
        <property type="protein sequence ID" value="CCD13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04260"/>
    <dbReference type="OrthoDB" id="1737014at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17444" checksum="2BAFAEF53EC19540" modified="2011-10-19" version="1">MIMRKAEMRNQRVTRRGLLDARSGAPEVTIILMVRTDTVIDSGRTDLKGASGVGVETEIEIETRKENEKKGVVGKKTGIGIGIGIAIDRCRVAVPMDTKDTTYSRKVATGGVAKVAIRTALQLTSMMIEKKMHVSDDSVTKRDAGGNMLWSRAFVISIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S9</accession>
    <name>F9W7S9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein TCIL3000_11_11980</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein TCIL3000_11_11990</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_40200</name>
        <name evidence="5" type="ORF">TCIL3000_11_11980</name>
        <name evidence="6" type="ORF">TCIL3000_11_11990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001076">
        <property type="protein sequence ID" value="CCD13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.11980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.11990"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40200"/>
    <dbReference type="OMA" id="KANPIMM"/>
    <dbReference type="OrthoDB" id="288077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="639"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC95706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC95707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="663" mass="71822" checksum="A0359CAD8BA9BC09" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y6</accession>
    <name>F9W7Y6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001104">
        <property type="protein sequence ID" value="CCD13308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40750"/>
    <dbReference type="OrthoDB" id="1560735at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="21515" checksum="9572D95456545492" modified="2011-10-19" version="1">MSSTLNQQHILTPYVYISYTIKFNVHVPVILPLICVREKFCICVHCRFFLCSAYVYSYLLPLCNVCVCVRNRVGVTRLVGNYLYRIVRKTSVDISVCISVAVMFHASLMARSFSQESFYRMSKYMKSRNPNEKYLRTGHIVLETLKRYHAYVLALVFTLGVTCYDQLKHPEKVRIPIHDGRSLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8C2</accession>
    <name>F9W8C2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 1727</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_42030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001161">
        <property type="protein sequence ID" value="CCD13454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42030"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="OrthoDB" id="1319902at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="PTHR21094"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="264" mass="30084" checksum="BACD8CFB5141A4E8" modified="2011-10-19" version="1">MGSNMRIWESLRSDARQADNLIERKISALEVMARSVDVEGGSGHLFERDSHNTCDTNRYSGALSCSSTNAPDTTAVAVAPEVRVRNTRERFEHSRAELEMALQRFETLLGTMEEAASTLPPESAALTHTERFRQLAAEKRRSLTRIIADFRRRCERIELLPNINRELDLHREDIGTQLLLQEQESLRHTQRTLNNIIDRGEQAHHQLRGQRDVFSTISGRLQEISTRVPFVKNVLSKIDSKRRREAVILGSVIGVCFILVVLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H6</accession>
    <name>F9W8H6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="3">DMQ hydroxylase</shortName>
            <ecNumber evidence="3">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_42540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="3">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42540"/>
    <dbReference type="OMA" id="HYNDQVR"/>
    <dbReference type="OrthoDB" id="1242061at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="PTHR11237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="268" mass="30078" checksum="8C3671F5D5A61D09" modified="2011-10-19" version="1">MASLVALQCCFICFLSPTPFGAISLCLNAVTPIRVTHHLLLIVIYALCCLIFSIYITPSSRACKSMLRRSLGSLERSAHAYNRYTRRQKLDEAIRVDQAGEVGAVRICKYQLLWLSPLDSSVPIVKEILGDEVVHEKVMNDLAHKHSVQLTSLDPLFHFGAFALGSVTALLGKEAVMCCHAAVEVTIAQHYNDQLRELQVLESDSILQDDEAKNWKEVKDYIAQFRDEEKHHQELGEQNGAREAPVYPVLYNGIRMICRLGVSLAKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8W0</accession>
    <name>F9W8W0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 1788</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_43840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001228">
        <property type="protein sequence ID" value="CCD13646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43840"/>
    <dbReference type="OrthoDB" id="1669419at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390017" evidence="9">
        <location>
            <begin position="26"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="14"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="292"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="43845" checksum="96E9CDC98B5E963B" modified="2011-10-19" version="1">MFMHNNLLTWSALILCAMQSDVANGGINTEAGKALCTVVRTLKNVTPWVSEQLTAVITKVNNLNLQILNHHLFNEGQGENLEIRCPEERKHLAKVHSILEEARNTTSKLVEKAVRAAALSAKSAGRLEEFIMVFAKANGASKRCLGTERTAATYEELSDCFSGSEIAEEHLIKIHESCDGASTQEPHLTAAVNAINFSTLQKNNIQNTGGTGCNLIKGTNCGIINGETILGKVWWGGGILTISGSFDGDMSKVEAGEFTDDARGAKWTAAPTTAIVHFDEAIKAFDTFKTTKESLQRIVEEASGELEKCKKQRKTTEKSKIKTGTKSAQEMCLENAVVLRNELREAQNLLDRYKKEKGELEPLNPENETVNKTLRTTHPSMGAADRNKPIKIFGLLIITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W914</accession>
    <name>F9W914_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04600"/>
    <dbReference type="OMA" id="TENIIWG"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388847" evidence="1">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="48074" checksum="B27D59A7D2939990" modified="2011-10-19" version="1">MCDRYIFLVVVVTLVGVVMVEARDLPALKLESAQGACAVSRLMKSMYNFVSSRNKEAQEMYESVERMYDLGRVRIAQHVLENGECDRMTFFVLFSQRIKENMTRKIRELASAGVKLVGAAGLAAGRLDEFINIFRHSWHVQTSHIFSTTYNHTYSFCLRGKGTKPVDKKSIVDCFMNDKETDDNGFVPVDGGDVHWLDQDDMGSLLDMRLKLVDGDPRDEHGQNRRCVLLSMEDGGGYLGGGNKGKKVLWADGLLGVTSGNTKKSGFTGSVRSSSYSTNIMWEAKPSSSIPVLKDFVVRYNDYRKLFDEVKHLSAAMTDDWTVDHLMKYAEGIASLLYKPEELDVLLSVDENEGNETAEEDQRRLRLRHTVEPFVGLNDRKQEWLAQYNKELVSKEFLAAEIQLCRSAAELHLRRNRWFFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W945</accession>
    <name>F9W945_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1815</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001259">
        <property type="protein sequence ID" value="CCD13735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44430"/>
    <dbReference type="OMA" id="KYCTIVP"/>
    <dbReference type="OrthoDB" id="865202at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="33112" checksum="5DD4EF0DC5F30F6E" modified="2011-10-19" version="1">MEVPHDDYDISVMIQIVKEVQRLLISKQFSTYSEFDREITNMLKNYKSIGDGFERFRIDLTKDAANSPDLASSLIDMNARCEARLRDFECSQKDQINDMLPFIRSTSRILVHGCGDLLALAIACAIQEREGVRFYICEGRPATAKYPQGTGAALLRKAAETHEGMRLAEKLSNYCTIIPDAGVGAVMNKVDFVVTGAYCVTEHGGLVHSTGSLQIATVASAMNVPFYVLCETFKFAHIFPLSTADLKQPEGCSDVPLVEFVPPSMVTLVFSEQGIMPPSAVTYEMFRFHTALFASGNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W975</accession>
    <name>F9W975_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1830</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001275">
        <property type="protein sequence ID" value="CCD13765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44720"/>
    <dbReference type="OMA" id="AMSAIRC"/>
    <dbReference type="OrthoDB" id="1271143at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30174" checksum="CB56856D0650FF63" modified="2011-10-19" version="1">MPVSLPDNQKDGLGDASPALSGKETLQDAQKMEYRATVLEAEGKEIESLQLMESALQVRCKELGTNTTSGSLLGETCDAAERVVMKCNVLGVKSFKESKYDVAAALLDYAIELTGEKSFPLREDDARRRRLLGVTLNNYGCMERHRGHFTLAIEYMQRSMECTGQQSPVAFLNISAIQTQLRLCEDAVESAMSAIRCLGPNPEDPSLLVVAHHNLAMALELIDPSRAYEEYSNALRLAHEVIGKKSEVTKTVEGNMQRFMQVAQGKHKASFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M3</accession>
    <name>F9W9M3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001324">
        <property type="protein sequence ID" value="CCD13925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46110"/>
    <dbReference type="OrthoDB" id="1706901at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24323" checksum="6C25976B0D734A3B" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGEFPMSSARARRLFANWKACLRAAGGGEAGRHGEGSRGFRDPTGDTHNCARECQACHGKGRKFMFQLRRSCCVRLNGVCVQVKNSLIHSICGVPVVEIAVAKDTPSTLRNVSCGGGGGLGHPRSSKGRGPNARGLFACRVCKWLLKACASMERHRIGRHGGATLPEDPPCMAALDAAEDAAAERRRWEERVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M9</accession>
    <name>F9W9M9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001331">
        <property type="protein sequence ID" value="CCD13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46190"/>
    <dbReference type="OrthoDB" id="1655801at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="719" mass="83033" checksum="4E80633404DD88FB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Z3</accession>
    <name>F9W9Z3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001367">
        <property type="protein sequence ID" value="CCD14048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00460"/>
    <dbReference type="OMA" id="MAKGQEM"/>
    <dbReference type="OrthoDB" id="766640at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STPPase_N" evidence="2">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18185" checksum="F160C8E52BC7B07B" modified="2011-10-19" version="1" fragment="single">MSNRSVFMNCDEIIKKLLLSPTHNTAATHGSSGEDGNNNHRTYTRMSRLSAFQSGRPQEGNARPDSSGAAREDLTEAEVRWLVMESRALFMSQPMLIEIAAPVRICGDVHGQYSDLLRLFDLGGYPPPANLIFLGNTGTGAKSLETISPPPKNWGSRAFFFSGKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA42</accession>
    <name>F9WA42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001386">
        <property type="protein sequence ID" value="CCD14098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47650"/>
    <dbReference type="OrthoDB" id="34513at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="872" mass="96472" checksum="608AF3C8657E09A3" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA92</accession>
    <name>F9WA92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48080"/>
    <dbReference type="OrthoDB" id="1659561at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394799" evidence="5">
        <location>
            <begin position="20"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="473"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="565" mass="60929" checksum="A19A15079793C967" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAB1</accession>
    <name>F9WAB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001410">
        <property type="protein sequence ID" value="CCD14171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05140"/>
    <dbReference type="OrthoDB" id="1686636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="35294" checksum="86CBB0C2E9F24454" modified="2011-10-19" version="1">MPKRLAWSPEGDEHDSWLPERACPKSREEEAAPLPEDDEWMVVIRRRQPPRNPSWTLRSTIREVLLEGMKDPHNLSLFDVLQLHYRDVQTKVARFTVGDFLRNPERCMKDKDRRKDIGMSMSQMRSRLRERLLHISYDLFSYHIQTLGDWAKKGRSETVEPIARSLLDRALKQAQETPTQAEERVQAEEPVQREPRGSRQGPVFLPSSSSSSSVSSCPGRESSPSTDVEFLVEFPPPPKTEENSSPHGTQPAPRRKRRASASMKSLREASPPTPQEVHPSRTPPTRQPSQESYSDVEFLGANPPPSRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC6</accession>
    <name>F9WAC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001414">
        <property type="protein sequence ID" value="CCD14187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48350"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20197" checksum="1A65D9EBD19C6085" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPHMHSYVSRFSIRDFARNPWRCVGEADGREKVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDFREGMVWAVCKMPSQPRGFLEAPYPIGYTGPIPMPDPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAF4</accession>
    <name>F9WAF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_48630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001427">
        <property type="protein sequence ID" value="CCD14216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48630"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388903" evidence="2">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="22981" checksum="B52FDB1A00BDFCCF" modified="2011-10-19" version="1">MTPLSTILSFLLPLPFPFLPQPEGISMSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPHIHSYVSRFSIRDFARNPWRCVGEADGREQVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH5</accession>
    <name>F9WAH5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1975</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001436">
        <property type="protein sequence ID" value="CCD14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48820"/>
    <dbReference type="OrthoDB" id="1720571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17492" checksum="6F15EC3A8DA3C709" modified="2011-10-19" version="1" fragment="single">MNHQWHDVLIVDDEGDKAFSDAAPLLLEALEIVSHTRMLHFSLGVDCLAAGLQSVKDDRFTYRAKMGEAREMRSMMASLLDSVHDSFSTIMETNKAPQQTGKGRTDDYRSLLRCDGGLIAPRSLKLKTLLSWDPAFSYKTFFGRFKRLCQIVADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAL9</accession>
    <name>F9WAL9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1990</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001452">
        <property type="protein sequence ID" value="CCD14289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49290"/>
    <dbReference type="OMA" id="RMCERGT"/>
    <dbReference type="OrthoDB" id="1659220at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="504" mass="58254" checksum="D5FB8901673D6736" modified="2011-10-19" version="1">MPYVTLHPGGRMCERGTFKKNFDEWLSDRGYVHPFIVIGTPGIGKSFATGSLLLYQLLHYPSEDLKVVAYFVSGKAYIFHREDRRVVFYEEQRAAVRKVNEMIRRGIVGYIIFDISENSIHIMDLPYVWGIVLISSPNVKKFHEFAKQRQDTLPIYMNCYEDAEFKAALVLERHLQVVNNQIKLEDVNLESDWKVLKERIRMIGPLPRYALASEATYKKRVEEVTRALLLMPDDFGYCMRVLANPHEEGTTHKLVKLVRCEVKDKFRCRNRVTSIYVLKELAKKLRQAHLRRSLIYYILCGAREMCAGLLEELGLDAFMLREAVDTLVEHFEHLPNEKEAKRESVLSQGGAEGRVPTIISEFASDGPKQELKTGRLYKPLIPNFPLVDGFFVVEGKGPKTIVLLQITKAKEHHTNKTTVREFRDYMGEVFEDWENIEGSYSWEIIYIQHADSTAIKKRLRCASSRYAANDTDLALWDRIHQYQVTLNSDTASEFISRSSDPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAQ2</accession>
    <name>F9WAQ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001468">
        <property type="protein sequence ID" value="CCD14323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49560"/>
    <dbReference type="OMA" id="SAYYPRK"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="153"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="622"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="941"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1171"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1382"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1106"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1140"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1405" mass="158026" checksum="09E0E85D06E59E3E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAQ3</accession>
    <name>F9WAQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001468">
        <property type="protein sequence ID" value="CCD14324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49570"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="550"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1022" mass="112974" checksum="B1FC69668CC5B967" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB85</accession>
    <name>F9WB85_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_51240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001546">
        <property type="protein sequence ID" value="CCD14516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51240"/>
    <dbReference type="OrthoDB" id="1668236at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="44532" checksum="0FF69B5A1C36C2FE" modified="2011-10-19" version="1">MKREPRTIGKGMLAVVVVVMAMVIGGVVAYPPGSVFNDEEYKALCDVFQASLDLWNASRTSSKKLDNLLEKHLCQALFGKSSGGKVDDFKEILPQEYNDPGYRLYRCGYCDYNTETYPGKSITHDLMCLCTPGKDAEPFYGYYWWIFGYYHKENGFKLCGRLREEMGVDLSHGWYAHKGKHQAKGLENSWKTVTMGCFNGWKNSNKTANQTLEEKVKRLSETLDNFKKKGLKKVNGRYKLGGFDEHNEADGSSEKHIHVRYGTCKYGRRPWWKKLEEVLQGKNPESLLFEHSVNQPAAGQGTGTEDDEEEGGILMEEGKFPSHPGMEEGPTSKTEGAQGVNATQTSGPINSTVIHLNSTRYGTMDGAENYSAQYQMLRSSTSTHPPASWLLCATFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBK7</accession>
    <name>F9WBK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001592">
        <property type="protein sequence ID" value="CCD14640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52400"/>
    <dbReference type="OrthoDB" id="1691803at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="25350" checksum="767017A58FB358DD" modified="2011-10-19" version="1">MAASLFFTSSIPLTHKHTRARLNLPHTCSGRHTHFSRWELSVRNVAGLIGATRPPSYTLRCFYGRLTLVWWLVFDRAVTWIVIISRSFQHLSEHLQKKGKKCQTLGAHSRSRVTEGCVVSENETCYHIRAARRSHMLLRTASIGRWGIHILLSSIFRWIVLPVNNWSMFCGSIALTSRATTLCLPVGDDCFTMVTNSFVKSSGRFDATDVMDGRPLIFLGGALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP3</accession>
    <name>F9WBP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001605">
        <property type="protein sequence ID" value="CCD14676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52720"/>
    <dbReference type="OMA" id="GAPCSER"/>
    <dbReference type="OrthoDB" id="1521647at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20030" checksum="4A4E9D71193343F3" modified="2011-10-19" version="1">MVSAELLCRDDSASASSLTDMVLTNCSRPQSNCGKEFLSVSGTQRLTSYVDIPVEDVHKRFSIEEEGAVAGECEAVPLPRRFGFDMIGLASVTEDILRGLYEACDVHHTGGVERGVLRELMRTSFSHFGAPCSERDLDRFFESVTPFHIRRRLTPEEQLTSLMPFDEFCVAFLSWLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBS9</accession>
    <name>F9WBS9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001623">
        <property type="protein sequence ID" value="CCD14713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53060"/>
    <dbReference type="OrthoDB" id="1687969at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="312" mass="35853" checksum="27D21AD2AA261EAF" modified="2011-10-19" version="1">MPKHLAWSPEGDEHDSWLPERTQPKSRKEEAAPLPEDDEWMVVIRRRQPPTKPSWTMRSTIREVLLEGMKDPNHLNLFDFLQLHYRDVPENVARFTVGDFLRNPERCMKDKDRRKDIGMSMSQMRSRLRERLLHVSYDLFSYHIQTLGDWAKKGRSERVEAIVRNLLDRALKQAQETHTQAEERVQEEEPVQRKPRGSRQGPVVRPSWSPSTSVSSGSSCTRRESSPSTDVEFLVEYPSPLKKEENSPPHGSQPAPRRKRRASASMESSREATPPMPQEVAPSGTPPTRQQSQESYSDVEFLGANPPPSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC24</accession>
    <name>F9WC24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_53920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001658">
        <property type="protein sequence ID" value="CCD14811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53920"/>
    <dbReference type="OrthoDB" id="1674035at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388959" evidence="4">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="85"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="36750" checksum="9C41C19837630E67" modified="2011-10-19" version="1">MALFVNLLLALVFICSWWGDAAGEPGAEIKSIDNAEQFALLCRIYNVAKNPPINHVDLQDPNKIVNEIDSINDSFADEKQHNESDKVENISDAQIKPITNTLEAAVAKAILRRINQKAHKILEEIRKMNATRDIAKVKGEFNQVIFGLEGNESDLKKGALSGVEGRANACGSSGLTSKGNSAGKNLVVDFFCLCVQNAEKNNGIEKVCGVQVGGKDEKHSWDDTNGPLGSSSMWASIKKECGNLLHQHPKSTEEGHEVLGDFLMHLKLGGVYRWGSNKVLGSGRKQGMLGTGVGADDGANGNGILCDGKKGYASKGRKSPPGGICVYYGPEKWEENIDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE2</accession>
    <name>F9WCE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001706">
        <property type="protein sequence ID" value="CCD14935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00680"/>
    <dbReference type="OrthoDB" id="1726051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17457" checksum="5A8476D330642DED" modified="2011-10-19" version="1">MHTCTSHMHRTHAHTPGTSSDAGCTHTHGRVQQQDTHCASATQHVMHLPHGEETKAGKPTHTFSFVYFHYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVSRGADTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE3</accession>
    <name>F9WCE3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_55040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001707">
        <property type="protein sequence ID" value="CCD14936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55040"/>
    <dbReference type="OMA" id="ACSECVF"/>
    <dbReference type="OrthoDB" id="689831at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="290"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="379" mass="40624" checksum="3CB2AF76F5AC3E66" modified="2011-10-19" version="1">MLLSIPAAHQEVVTSLQFSPYYPSVFCSTSGDDTGALWDLRNSPDSCNIAKLVCHSDPVNHALFVEGRDQLLLTASDDRTVACWDVREISQPVGVIRGFGEGVNKMLRLPSGVPGGGGGGGSSNAVPSLLVACACDDGQVYVHSVGTPEDSQPQNGLRSENAHETLDSLGTLMDRFWVSTNTVNDLALTPNPNLLLTASEDNAIRLWNIAPLLNGRATGDDRLVASFEEFEDPVNHIAVRYSSPPNEVPRGFDSATPSSTCWLYAACSEFVFAVDLDPINGVFGGEARTFSGHQDYVRGLEFFSEETLLTVSDDSTAIEWSLSTVQLVRQVKLHEGLVMASAMSAAKDILVTGTDNGEIRAWSLPFSTETCCASSPCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCF7</accession>
    <name>F9WCF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001715">
        <property type="protein sequence ID" value="CCD14950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55180"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="519426at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGGY_C" evidence="1">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20038" checksum="D832753054C41FEE" modified="2011-10-19" version="1">MRRNMNLFGHISECEKLARSVPGTQGVVFVPAFSGLLAPYWDPSARGTIVGMTLKTTRAHIIRAALQAIALQLNDVVGSMKRDAGLSLTSLRVDGGLTKNGLLMEIQSNLLGVDILVPSMHETTALGAALCAGLAAGVWSSLDEVKAVSLRENSWRTVSPTGSPKERAEMIAEWKEALKRTKWAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCK1</accession>
    <name>F9WCK1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_55620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001732">
        <property type="protein sequence ID" value="CCD14995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55620"/>
    <dbReference type="OMA" id="LVRCSKT"/>
    <dbReference type="OrthoDB" id="1637451at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23094" checksum="07981C9527DEF06C" modified="2011-10-19" version="1">MDLFFFQVIDRETLTHASLFSVGVELLCAVIVFVIVGVLLRVLPQILVVWRRKHRSLRHEVKEETERALMESSKVPTGVSRNEVCIKRAVVAVPQENGGNAKNNDITENGEGKSLDDALDAFFTEESMLHEALLDVSTGSTVKTKQEKFLKALAPPKESVHHKANGRHPPSARANPTVAAPNTEGSLDEALERFFDEENLLDEALLGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCV6</accession>
    <name>F9WCV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001775">
        <property type="protein sequence ID" value="CCD15104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56660"/>
    <dbReference type="OMA" id="NTHYPVA"/>
    <dbReference type="OrthoDB" id="1032251at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="753" mass="81449" checksum="8FB113E75AD7BD29" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCZ0</accession>
    <name>F9WCZ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001792">
        <property type="protein sequence ID" value="CCD15138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56980"/>
    <dbReference type="OrthoDB" id="743037at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16218" checksum="A6AFF75B602FD741" modified="2011-10-19" version="1">MMGVLRGCGMQKQGAIIISLVYSVIGVPLGLLLFFLTNFGIGALWLGPAVGVTAFGFPVYLYMMLRYIKWDRLEPSTETYDAMMEEDSGVSKGSNEGRISHEPLAFGAPRGGSFAAGAAGGLKCEPLCGAGSQLMAEEAGKEDSASNPKANKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD97</accession>
    <name>F9WD97_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2339</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001841">
        <property type="protein sequence ID" value="CCD15248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57900"/>
    <dbReference type="OrthoDB" id="373523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="596" mass="65789" checksum="1E8CC8EFA26BDADB" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL7</accession>
    <name>F9WDL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2379</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001885">
        <property type="protein sequence ID" value="CCD15371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TREMCAG"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="712" mass="81781" checksum="98D299BCC749BF07" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDM9</accession>
    <name>F9WDM9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2383</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001890">
        <property type="protein sequence ID" value="CCD15383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59090"/>
    <dbReference type="OMA" id="AMWRELN"/>
    <dbReference type="OrthoDB" id="338241at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="69637" checksum="899050905EA19F39" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDP2</accession>
    <name>F9WDP2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_59230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001893">
        <property type="protein sequence ID" value="CCD15396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59230"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="43363" checksum="45703E5A5834F457" modified="2011-10-19" version="1">MAKNVRMRVMQKPRRPTGKLLLLCAGIVSLIIILCVLWGTSGCQPNTATGKDSLTPINYDAYLRFIPPDVVSTWKAHEFLVVMGIPSVDIDGRQRRRDLQRATWWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRKRMGEGGGWGPEAQLVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRVNLLWKSLELVYATGACYTLSKDAAQAIVSYKPLAALLRKPYSIWHMMQYKMMSVDDEDVMVGRVLARKIRFKGLIVVNVGRCRLHGSGKTGLFPAVTQKSVVVYHIREEDYQRLWEWFDDNGRSHVPSQLHWFSKTSATLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDP3</accession>
    <name>F9WDP3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_59240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001893">
        <property type="protein sequence ID" value="CCD15397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59240"/>
    <dbReference type="OMA" id="IYHISEV"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="43933" checksum="9CEE671462ABD3D6" modified="2011-10-19" version="1">MLVEKPAVLFRARKSRISVYMLPLMTLLALAMVSYTLYGIGNGDHTPEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDIDGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRRRIGEGGSWGFQSEVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRASLLWTTDDIVFAAGYCTTLSKDAAQAVVSYKPLAALLSKPYSIWHMMQYSSMSVMHEDIMVGRVLREKVKFEDLITVDMRSCKFHESGRRGIFTTVTQKSVVVHHIREEDYQRLWEWFDDNGRSHVPSQLRWFSETNAIVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDP4</accession>
    <name>F9WDP4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001893">
        <property type="protein sequence ID" value="CCD15398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59250"/>
    <dbReference type="OrthoDB" id="1096950at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="28063" checksum="B034A9C0DAB64B2A" modified="2011-10-19" version="1">MPMACADLVELLQVCVRGAMAAQRYIILELLQLDSSDAPRRDVRIADFEPQSLRMLRDRLRHVVTVSVKGQLAHKEGTAANDLVTTADIVTQTVLERALADAFPDMPFTLVGEEDANTSAAIASQVDDCMRRFLVADFPIPLQADLNRHACTESRLICAETYEELRSRIGVFLDPIDGTNCFVDGHWTAPLTLVGITLDGLPVAGVVNRLFYCTIDHVTCGSGAECGSLSYVWNDASTGPFLLHEGRRVHVGARHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDU2</accession>
    <name>F9WDU2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001914">
        <property type="protein sequence ID" value="CCD15446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="16140" checksum="44AEB7F10653DE22" modified="2011-10-19" version="1">MAAKKKLMLHSPSLLNCFESGNRTRRSRGRKKSHALLVYNGFKYVYMSMTLNASTLTVIRSPPSNVPLWHSAFMNAKSNRHQKEEKKRHNGTSQHHKTKKSIRPFNNKCKHPPRPNLRVRFGRAQPPDGITPAWSHPPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDU6</accession>
    <name>F9WDU6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2406</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001915">
        <property type="protein sequence ID" value="CCD15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59700"/>
    <dbReference type="OrthoDB" id="1715553at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16881" checksum="EC872FAA49E604FA" modified="2011-10-19" version="1">MFDVSRSNAYSPLGDGPSLRTLSDLPPREGCIYSQHRGVCSYSERDLRGVPRTYGCNYLGGSIPNPPELTVLDAPHAVWVSAFIPCWRLVAVPTPWVLRTKHFVAMCGTFCGELACHRLRGALGFLNLVSPNPPNTDVLKPIKTWMGYVATFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDX6</accession>
    <name>F9WDX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_59990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001926">
        <property type="protein sequence ID" value="CCD15481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59990"/>
    <dbReference type="OMA" id="DESHNIE"/>
    <dbReference type="OrthoDB" id="186062at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="DEAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="4"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="407" mass="45706" checksum="82AEC8765FB518CB" modified="2011-10-19" version="1" fragment="single">MVESSSPYVMPFEPYAVQKDMMQTITTSLLSSSPHLPIAAVEIPTGCGKTLALLSSVLRYQAELEKLTPHELEQHFRKRRCGARIAEIAASTDTAVQQTSWCQCDGRTPPTAELGLLRTDEGAVDDDSLWRVSSLFFKQFRPPSGKRLRVESDGKGASELSRQHRPPPCTIFYVTRTHSQLRQSVGELRKLRGLERLKMNILGSRKQYCINQHAMRAYASKALPAEGNNLGEVCDKLVSLGQCEAVHGYGVLGSRALTRPLNQSRSDKVWDIEDLVTEGVGMKCCPYYAARDLVFFAHINFATYQYLLDPLIRHECKMEPALKNHSIIIFDEAHNVSSVCQEALSMEMPLDALQLILSEIQPLINPADAPATLSYPREFKLTKWTLVQLFTLLYDVFNAALKFVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY6</accession>
    <name>F9WDY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001932">
        <property type="protein sequence ID" value="CCD15491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60080"/>
    <dbReference type="OMA" id="FFMKCKM"/>
    <dbReference type="OrthoDB" id="1398309at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="PTHR12857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="DUF866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17558" checksum="D8835738B6B12080" modified="2011-10-19" version="1">MPQYSLLASAETEGVERIQPMRPRDWGMKVECDSCREVSPNYIYVDETEERENAGGGTRNAVFKCSFCKTVITVDVDPSSYGAYYPESEDDTPLVVMEVRGATPVELDVGSNWVVVSEGATFEGADLSTDWMEYDEKSGTAVSVSQFEVSFHRLKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY7</accession>
    <name>F9WDY7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 162</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04330</name>
        <name evidence="2" type="ORF">TCIL3000_0_60090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001044">
        <property type="protein sequence ID" value="CCD13167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001932">
        <property type="protein sequence ID" value="CCD15492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04330"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60090"/>
    <dbReference type="OrthoDB" id="1717077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18389" checksum="763A9A44BF0B1373" modified="2011-10-19" version="1">MHRGCSLGIHSYVKLLCLYARNLVGIGHLSVVPGSSALSRPPHGLVQSQQTDAGQTHSECIAAFPTVWSEVNERGQALSCVCGHGNSLLCRLLLFLSGNVEYNPGSMKLLIPSGCYQPGRLQQHRVVACLSDTGNPFWKEVVEMRSLQLYLVFNILAWWFELHVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE49</accession>
    <name>F9WE49_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001952">
        <property type="protein sequence ID" value="CCD15555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786902at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="14269" checksum="21CE825455573980" modified="2011-10-19" version="1">MPSQKKVRALPTLCVTPSQPCAYLVQPRASVVRCARETSSHGGDEAAGGSNHPMASPPLVLHCSAPTWRGRGSGPFVVSLVRCSDPLGAAVFRAAACDAASHNSMRKPPWLPQSLHTIPARVRGRAPLRTALANSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI7</accession>
    <name>F9WEI7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002017">
        <property type="protein sequence ID" value="CCD15697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00780"/>
    <dbReference type="OMA" id="LMMMIED"/>
    <dbReference type="OrthoDB" id="1692088at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043636">
        <property type="entry name" value="L1_RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004244">
        <property type="entry name" value="Transposase_22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11505">
        <property type="entry name" value="PTHR11505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02994">
        <property type="entry name" value="Transposase_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase_22" evidence="3">
        <location>
            <begin position="191"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="266" mass="30639" checksum="698045B16CACE211" modified="2011-10-19" version="1">MAKGKRKNPTNRNQDHSPSSERSTPTPPSPGHPNTTENLDPDLKTFLMMMIEDIKKDFHKSLKELQESTAKELQALKEKQENTAKQVEIIKEKQENTSKQVMEMNKTILELKGEVDTIKKTQSEATLEIETLGKRSGTIDASISNRIQEMEERISGAEDSIENIDTTVKENTKCKRILTQNIQVMQDTMRRPNLRIIGIDENEDFQLKGPANIFNKIIEENFPNIKKEMPMIIQEAYRTPNRLDQKRNSSRHIIIRTTNALNKDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF66</accession>
    <name>F9WF66_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 354</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09200"/>
    <dbReference type="OrthoDB" id="1732665at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="16458" checksum="1DD5C5B8DC80D83A" modified="2011-10-19" version="1">MNKTAGIKGTQCTFQTVCSPHAVQQCVLLWQCVDMCDAFPSTDCLHRSLAGATLKMKENMETTNNGTYTDTGGKQCKYEEITMGFGTFVHLLSAPATAVTLAPRESRTTAATSSVVLAPHISCKSNLTIGPSPAAGGLGLTRVTATAYELTSSVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF90</accession>
    <name>F9WF90_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002116">
        <property type="protein sequence ID" value="CCD15958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="16133" checksum="A0F0987B45CD0F58" modified="2011-10-19" version="1">MPTMLEVSAAQVESKQPEHSQFYHNEGNEEQITQKTSLFAKPFVPRKFQNALHLRFPLLHHFRPNGGLLLYKFLPCLLTFALVLQPLLLELRNVHQLVVHFMDHVINHTHCSFCVTPMDLHAHNALRACLLLQCIVHALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFB5</accession>
    <name>F9WFB5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 367</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002123">
        <property type="protein sequence ID" value="CCD15983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09550"/>
    <dbReference type="OrthoDB" id="1706154at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20124" checksum="B0FDC9A4A6DA2713" modified="2011-10-19" version="1">MLHLVLPTPFDGVPKTISSIARSVSQFVSMNRQSITGLAALQTNWMKYEYTTLCIRWHHLEPDTGRNIRHSLGHYFSSSEKSNTCLGWLPPDTLFPCTVWVPQLNFIYQVCWINQLQPEANQIRAAGSMQVNTILHTAPITHITRVAASLRVVAKRAYMMGPTSSRVDGSGLCHFHGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFF8</accession>
    <name>F9WFF8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002139">
        <property type="protein sequence ID" value="CCD16026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09970"/>
    <dbReference type="OrthoDB" id="1741026at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="22082" checksum="234D369A30E3348C" modified="2011-10-19" version="1">MIAVQITFSSLSFFFLIFYMQRKEKKENFIAHFFFFSSLLFLVCSFFVFFSLFSFVTFPTHAAQHSEKYKKNYFAFPPPPHTQNTPQRLHRCTMESATRPARAHARTLNGGFFFSFKKRRKKNEGAIWPQMEKEKQTKKKTGTSGVLATGGKLTGTKQREKEKRTGVLQACWGVVYNCAAWHTRVCACRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG2</accession>
    <name>F9WFG2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Transaldolase</fullName>
            <ecNumber evidence="4 7">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_10000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 7"/>
    <dbReference type="EMBL" id="CAEQ01002141">
        <property type="protein sequence ID" value="CCD16030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10000"/>
    <dbReference type="OMA" id="KFGYKTL"/>
    <dbReference type="OrthoDB" id="1402459at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="PTHR10683:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="333" mass="36486" checksum="17D5E0E7693F1AB4" modified="2011-10-19" version="1">MNQLEALKKHTCVVIDTADFSLLKEFSAEDATTNPSLVLAGSQLPQHAHLVTGAVEFARANVDRFGDGLLASSTDRKAQILELAVDKLTVSFGVEILKAIPGRVSTEVDARLSYDVARMVQKAKHLVRLYEEAGVTRERLYVKIASTWEGIRAAEQLERDGINCNLTLLFSFGQAVACAQAGVSLISPFVGRVLDWYKAKYPERADTFVGANDPGVVTVTRVYNYYKQHGYKTIVMGASFRNTAEVLELAGCDKLTISPKLLQELASTPGEVVRKLSPTQFTQPIPKLPELTKAESLFEGEPNDMAVEKLEEGIRNFATDTGKLEAHIVTLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ7</accession>
    <name>F9WFQ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002177">
        <property type="protein sequence ID" value="CCD16134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10850"/>
    <dbReference type="OrthoDB" id="1730556at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16202" checksum="3A02F7F526BEC533" modified="2011-10-19" version="1">MKSACNKWAALALPHHTHTWPSLLSSLPHYTTGGSICHGGVQPKSAGTTHPSLLSTLHMPFSAASSIQLLTGISHGAVARPCSSTLKQIAFRVGNMRRLLPTVTQHSSPSGTHAKPLHPLRKPKPPEVKAALRQYGPSDIAVLASSVCCNHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFV2</accession>
    <name>F9WFV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002189">
        <property type="protein sequence ID" value="CCD16182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1705837at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15173" checksum="CBFA0E23648F8000" modified="2011-10-19" version="1">MQFLGKCETLCTPLNPPACCFGRPFRQSSGHKKINDSGDFLRHNSITSSLLEHCLRPRATAQIPKRHPNGGPRGACVPLWSNYRTSKQWPAGSSDGAYLSGCPKQAQPSTKQLCTVMLDRNTPKRAATISVDRLHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG87</accession>
    <name>F9WG87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 476</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002244">
        <property type="protein sequence ID" value="CCD16321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12600"/>
    <dbReference type="OMA" id="CDNPTSM"/>
    <dbReference type="OrthoDB" id="1474195at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="39349" checksum="B07645FFCB9684E2" modified="2011-10-19" version="1">MVEPQEGNIYARSAILRWAESILQGEYNSFTDIQAKDVAVLLYAIFNDSRTVGERVGPVVSLQDIQFCDNPTSMVRLLNAKRVLSLVQSLSSCSSEVSAAAGNDTNGDGGCLVSGGVGNMSACAWLEGKAFVEELKMWRWIRTEAFKRGLEANELTERVRTFLGRASGSGAGDEDAVKKLGLAAKRSRADQGPVECAAGIHHEAPSSAVVQTPCGVREDGSAVDEQRDVGAGRPIAMDAKGLGNQVNEDLARTGEGATGSLLNITCDGVEASTGLLNVLEDVMKELNEQRHAVGENTGQGTFEGNRNEAQAQGGLQGNCDQTSECSSCPAIYATAIRHNYAAIERLEALRKLAVTACLRKDAAGLLGVLSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGR4</accession>
    <name>F9WGR4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01002307">
        <property type="protein sequence ID" value="CCD16501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="826926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PTHR12320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="15658" checksum="CC6156967C0456FF" modified="2011-10-19" version="1">MNVSRGLLQPTKSKALLGFSFRAVKWAPHPKRADTGGEDAFMSHLDAQGVFDGVSWWRNHVGVNSGLYSAALARSLHEVIEEVAAPATMSSLDLLQRAYDRSLAKGIPGTSTALVMTLQCSGGGACTSDGGETTEFINDVWTLQCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW8</accession>
    <name>F9WGW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_14700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002339">
        <property type="protein sequence ID" value="CCD16556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14700"/>
    <dbReference type="OrthoDB" id="1673731at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390369" evidence="5">
        <location>
            <begin position="25"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="38666" checksum="5252506B8A27FB12" modified="2011-10-19" version="1">MMTAIKIFVAACFCFMEVVVSINGKDHNRAQYNVLCDLLKVAVGRWGNAGESLSPPLREALERTLFGSAGGGTVETLKKELPEDYKEAEGKTSSRTAWCGKPREKDGHYDIKQVRFPGHSATHDLVCLCTAGDHGWPINSGSEKLCGKGPNELGVESKKQGWGIQGQGKDQIQATWTNVTSECLKGDGAGANLQKALEVFRNTLTLEPDSDKNGKRYLLGEGKFSDYPCSGNNQVCVMYYNTTSNAKHKPWWKDLEEAINIDEQMQKTRKEEKRKQKEIPEKKETKNQEKSQPTQEPRTAALTSAPQGSQDAEQENPENISNPIATLEETSGTFIIPPCTWFLGTFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH29</accession>
    <name>F9WH29_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_15270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002365">
        <property type="protein sequence ID" value="CCD16618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15270"/>
    <dbReference type="OMA" id="HIANDEY"/>
    <dbReference type="OrthoDB" id="1407357at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="24475" checksum="FFE64A65334EE0C5" modified="2011-10-19" version="1">MGEGGSWGLEPEVVMSRKTYLWFQFALHMFPNAPYLVKGDDDMFMRVPQYLADLRVMPRQGLYMGLIYRPLFPWKPHHFVFATGVCFVLSKDAAQAFVSYKPLAALLSKPYSIWRIMQYFSVSARHEDVMVGHVLIRKIKFKGLITVNVGRCRLHGPGSNGLFPVVTPKSVVVFHIQEEDYQRLWKWFEDHGLPPAPSQLHWFTQTRAALVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHF7</accession>
    <name>F9WHF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 643</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002429">
        <property type="protein sequence ID" value="CCD16750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NGECFRR"/>
    <dbReference type="OrthoDB" id="1654423at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="893" mass="100269" checksum="0D1C177F36A7E8B2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ5</accession>
    <name>F9WHJ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 657</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002445">
        <property type="protein sequence ID" value="CCD16788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16880"/>
    <dbReference type="OrthoDB" id="1659167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="574" mass="63479" checksum="449638FA755215D3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI78</accession>
    <name>F9WI78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 741</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002538">
        <property type="protein sequence ID" value="CCD17023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18850"/>
    <dbReference type="OrthoDB" id="1731030at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17558" checksum="F409A85591458C31" modified="2011-10-19" version="1">MKCFGGEWNLFLENISSYLNLWHIFVYDDEEIEEHGLHGEECYRERRLVHPKYRKRVAESDSAYVRLGREARATLENQILDRVMRCERCKHGRLCKECTEGLMKLPCTSALCWITAVHRVKRVTGSRGLLAWDPLLPLVVTDNPSDAIPGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI95</accession>
    <name>F9WI95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_18990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002550">
        <property type="protein sequence ID" value="CCD17040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18990"/>
    <dbReference type="OrthoDB" id="1260050at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="56"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="230" mass="25186" checksum="74D8D567FC0BC8E0" modified="2011-10-19" version="1" fragment="single">MEACTRWFFYFIPFPSFRSTYHFSVFFCGEIFFFAKDTHNDFIVLLFYATAGKSAMKIILRSLTGKEHEQEVTPDTKVQDIKRVLEEEYAPESLRICYNNSVLEDLETMGNLGVGDKSVLVFVGKKRTIQKLVAKAIEDTLSLASVGQTQEQNVKEAPHVSEGSEAPTTASAPTAGEQPSAETAAPAPRTGSSVAATQGVDPALIDSIAAMGFEDRDQIALALRAAYMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIB6</accession>
    <name>F9WIB6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002562">
        <property type="protein sequence ID" value="CCD17062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19190"/>
    <dbReference type="OrthoDB" id="870358at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="439" mass="49155" checksum="A2FF5A3CD28DC757" modified="2011-10-19" version="1" fragment="single">MMEGTEGTERCAASTSTIIEEIRALAKSMLESTEAVRQKSQYVENCKTYDALLSVLGSTPLTKRSTTSQKHQSHSDPNGIFPSGTDEFSSCTTTDRTDFNNCRVQKVLNDDANFCETELDDAEVENASTVQDGYECPSTAGAFCSMTKGSNTNKIITDFSADSDENVYDGVRTQVVFKAVDPGLYQDISSCTWQPEPLLLHPETGETVEDDSEDKDDIGSDYENDMSVMGSKKIYRVPSFPFGGGITEGQARFLSRTFFDTINRGGLATSTRPIHISTKDFIEYKYTECATTEAERSRFKPSSPFEFVVELERGVIFDAVRARESRRKEFRRLAEEGKAPITMGSFNLRVIMDPLKTGFEEEKTFPIERGTIIADRYQIVELLGKATFSRAVRCYDLYQPIYEDDEECNEREKDVLTDGQSRTTDAEGSGEINNLTKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF3</accession>
    <name>F9WIF3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002582">
        <property type="protein sequence ID" value="CCD17100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19520"/>
    <dbReference type="OMA" id="FFMIRKE"/>
    <dbReference type="OrthoDB" id="1590264at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19714" checksum="BBE08C9AEABFF30C" modified="2011-10-19" version="1">MRAFRLTKFVAASGLVRPQSTGGFGRQPMRGQYQNQYQDQNQSHQRFGGPRDGRHQRGTSSPGPSAGGCHNRLSEPQLVAKLLEHFPVGKTSVPVNKWAPLVPDEIQEALVPFGGLAQFAAAQTNFFNIRKENGMTIVTLSTMATTLCAERDKIIKKREEKAAAYAARRREQPRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIL4</accession>
    <name>F9WIL4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_20070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002616">
        <property type="protein sequence ID" value="CCD17162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20070"/>
    <dbReference type="OMA" id="RRCARAN"/>
    <dbReference type="OrthoDB" id="1458782at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389176" evidence="3">
        <location>
            <begin position="26"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="509" mass="54170" checksum="5AA3E45D757B9F39" modified="2011-10-19" version="1">MRTISFIYSKIAVLFFVAFTCPVSAVHTYAVFPLSSSGNMSFFRRATRRCARANMRLATPSSLGDASNVVKLLDRCGPPNAPVLAGGHTVLCSDRFMLFFWSPVLNAPQYPVEHADLYCGRRHIQSEMHKCEVFGSVAGRLFYQADMKPESGVSCTSPVAMDYDPSSLYQMEVPKIGHGGLLAWFVSRNNTDGPHTTLKSLEVDVDRPNRAIMGGESFLVSHVLCQGGRASIVSDSKCSFNAAQAFASLSNNSVVGSSSKGIHWLVAAFVIILALLALSLIVVGIIWAVSSNKSSGATGQGDGGFRSGRWQGSRPSTTTVPVGAPLARSSSSRVPSRSGSRYGNGPSQRPGTGTVSVQRQMNVGAESVARTGSFRGPPASRQGSFSENPLQRRSSLYGSGVQRGDSFRNSSMSRLGSFGGGNASRPTSLYASPVGGSLNLRNTDQSREDGSGRNNIPEQISISAGGASRRDSFNRNAVAQNGSFRGPNFSRRGSFQSNSAPQRGGLFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ4</accession>
    <name>F9WIQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 821</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002626">
        <property type="protein sequence ID" value="CCD17202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20390"/>
    <dbReference type="OrthoDB" id="1473359at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1121" mass="121816" checksum="2B93DECCDFC3C816" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD3</accession>
    <name>F9WJD3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002712">
        <property type="protein sequence ID" value="CCD17437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22560"/>
    <dbReference type="OrthoDB" id="1674767at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395109" evidence="5">
        <location>
            <begin position="18"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37156" checksum="169CDCC1FD6E3CA7" modified="2011-10-19" version="1">MKLINVWVVMFMVVVCAEQSSASLNEDHNKEAHKALCDLMKAAVGKWGDRGQGLSEPMKKALGKTLFGREEGERVEDLKGKLPGDYEKVVNEVDSRGLACGQPYEDSYNEPPPRWSGHSAPHDMVCLCTLGKNGWPLNDNQKATTLCGKNANELGGGNDGWSGNGTGITQIKATWTSVATPCLDGVGKGDLKEKLKDFLRKLVQKNTTANPNRYQLGQGTPGDDHACTGTNNLGVCVMYYNSTATYPKPWWTELQNAIPEEEEIQKQLAEQEKQKHKEDAQKSDSSQEAVLKSAPTTTNQTEQNKHDSNLSDTIRKFSIKSGTPISMTSSWLLGALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJF2</accession>
    <name>F9WJF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22750"/>
    <dbReference type="OrthoDB" id="1683757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="30103" checksum="A352B1EC97B4F287" modified="2011-10-19" version="1">MSKKSNETQEVNEVHASKVGVDHGEYGGGHLGEGQGRLGCNECVELFQYLLRQPLWHAPPYCCDHAAVSGKSGEVCPRCSQTGVYPTGPEPQARAHAEAPPTQPRQTEGCRYCFPGGVETPWVHSGYRTDGAHGVGPCLPACHAPQSTQRGSSRKHLMKRRSGECNRIRGACTLVSFSVHQSIFCSIIAIPPHYSSTRSFLPTIIPPTHPSPQGITMSNSPSSPSPAGMAQDNTPWSMEKDVVEVLLKGLGDPEKINLYRFLDLWRCVNAFLRFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK1</accession>
    <name>F9WJK1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002737">
        <property type="protein sequence ID" value="CCD17506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23230"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="22986" checksum="D08B095F208CE25E" modified="2011-10-19" version="1">MTPLHSILSFLLPQTIPFLPQPEKVTMSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKGIGKPEGINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK9</accession>
    <name>F9WJK9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002741">
        <property type="protein sequence ID" value="CCD17514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23310"/>
    <dbReference type="OrthoDB" id="1209592at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="278" mass="30603" checksum="0C7D2F27A3698792" modified="2011-10-19" version="1">MDLLYEEINAPPEYIGHVVGERGATIARLQSETGATITIIDGCKVHITAEDPTQLRAATECVRQIISDAINPDYEGPDGRRLRKEAAQLASKRAQLFNEATRQREEGNMQQMSALLEQGKQVGEQMKLTNREAAAAIAWYNNEGKGREGNYFDMHGLRVDEALEMLRARVEALRVALKGASGELRVITGVGRHSGPEGAKLRRAAVEFFRAEGLVFEEVSAAEIRATVTAAGPPVGHHQPQREADQPVENVEKMTGSPGEHQKPQLKKVEETKFCCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJU8</accession>
    <name>F9WJU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 955</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002775">
        <property type="protein sequence ID" value="CCD17606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24130"/>
    <dbReference type="OMA" id="RICACEY"/>
    <dbReference type="OrthoDB" id="247838at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039941">
        <property type="entry name" value="TT30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20931">
        <property type="entry name" value="PTHR20931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="234" mass="27692" checksum="580C3F053D85FCA7" modified="2011-10-19" version="1">MAQANIYWEIENYPMVEKLFRQSAEFCSEHEIWKLNVAHVFFMQETKFREAIRYYEPVVEANEENLLNCSAIVLANLCVAYIMTALNDKAEEIMRRIEREEEKLLYVDPEKQPLHLCIVNLVIGTLYCSKGNFEFGISRIVKSLEPYHRKIMTDTWFYAKRCFLALAMHLAKHMVVLKDATFDEILNFFDQADHYGEKIPAFVHPDPSKQETSSKNSVRWEARQLKHLYLQLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK46</accession>
    <name>F9WK46_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002808">
        <property type="protein sequence ID" value="CCD17707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24930"/>
    <dbReference type="OrthoDB" id="1706152at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19412" checksum="023A6224604D5F22" modified="2011-10-19" version="1">MISRGEWRDSCCNISHALNPSLGLGVPITKLSSTLSTRLMRFLGKCETLCTPLNPPACCFGRPFRQSSGHKKINDSGDFLRHNSITSSLLEHCLRPRATAQIPKRHPNVGPRGACVAPWSKYRTSKQWPAGSSDGAYLSGCPKQAQPSTKQLCTVMLDRNTPKRAATISVDRLHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W472</accession>
    <name>F9W472_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000523">
        <property type="protein sequence ID" value="CCD11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28930"/>
    <dbReference type="OrthoDB" id="1446852at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="18605" checksum="B555216442C3C551" modified="2011-10-19" version="1">MNTAAVFSPSLLRRTALVTCMSVSSVDRAGLNPACCGCNLSSMQSLTLRATMRSINLHSVLVSVTGLKDAMLLAGLFGFSNGTMMPCFHLAGTCPVRKLQLNSRNTHFFATLPSSFSSSQCISSSPGAVPEESSRSATSSSASVMGRKVLRLVLGILISGACGALVDLAMYILANACAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A7</accession>
    <name>F9W4A7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_29210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000534">
        <property type="protein sequence ID" value="CCD11996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29210"/>
    <dbReference type="OMA" id="FEAQHQR"/>
    <dbReference type="OrthoDB" id="1484985at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="269"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="40309" checksum="87C9314F4F3F6BDC" modified="2011-10-19" version="1">MELSVPTLDLANAKGVVNFHNDRAERGRGTTVTSLPPKPKPRSFSAMNEKQTYESVLLLTKSLHAPAKPLLWGHKNVNKRECVSVSLDNFETAPRIKAVFNTPRSVKACSLAAVNPRDLLRRQLSDFMGHGVPENLVQMRYTYYESRRNAKIAQVRQIRDSIPVTVSPEVNGQEEQSSPDNVDDGRIPKGRASSCELNKPPVRRSISNGAVSRSSSVAYKTGVDKTRTSSRRSTIYGSDGRSASTGVVKVLNRIMGENRSPSTADYDMMKRIEEREERANEVKQRADEMEASRQRALVLKELKKEVKGINKLIERENEKNNAVKMRRQKLDIRLLRARERQKRSEQERLNRISSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4L6</accession>
    <name>F9W4L6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1201</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_30240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000576">
        <property type="protein sequence ID" value="CCD12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30240"/>
    <dbReference type="OrthoDB" id="1668348at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="19269" checksum="AC3471D932120A03" modified="2011-10-19" version="1">MMCMCAIRVGGSAARITHACGLKNSVAMEGYEVGHAYDAWEKIVILCDTSERAVDAAALRGALRSFSNSLGFLGKEDSPQYKSPHMLGSMGRHPKDGCTGDMGFQASLCVDYRALIDPDDEGTRNLRMIPWYNLVASAADLLDQGNNAAVAAARLHSQMQAIAEVALSIYYEGSGKVGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P1</accession>
    <name>F9W4P1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000583">
        <property type="protein sequence ID" value="CCD12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1668909at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388664" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14739" checksum="7BED3E6C865A18B8" modified="2011-10-19" version="1" fragment="single">MATEAHLIWLFPACVLMLCLEVTCENKRQAIPTEVGESICSLSNKLKDVAPWTVGQVAALKKNRDEYASKFLDWKLHFHGSPECGENESILEEILKVLGKVNKEIKTLPAKAIRAGALAVKSAGRLDEFITIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S0</accession>
    <name>F9W4S0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000597">
        <property type="protein sequence ID" value="CCD12165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30740"/>
    <dbReference type="OMA" id="KHGSANT"/>
    <dbReference type="OrthoDB" id="1095528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="263"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="547" mass="58613" checksum="4C063EE4EE383AF2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W534</accession>
    <name>F9W534_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000651">
        <property type="protein sequence ID" value="CCD12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11568" checksum="93460E2917FE18DE" modified="2011-10-19" version="1">MMFHTHKACRVQNEVPYMTIKRLHRCYCLGLEHGQQRQQAIQNHRLGSVSTANHRINVLVMVVTHCPVSSQYDFLSFLINQIRHSTASGDASNTTDQPIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W581</accession>
    <name>F9W581_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_32220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000671">
        <property type="protein sequence ID" value="CCD12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32220"/>
    <dbReference type="OrthoDB" id="1673830at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="88"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="42235" checksum="4D0824567E33FB3B" modified="2011-10-19" version="1">MKRIFNQLLILFYYVPYFFRIEMSSMIILKSLKVILMLRVVVMGVPENIESVKEHTQDYFGPLCDVMRAMSGVWQSVTGPEEYSTEDIKKLDETVGRSLFGSKWSEGRTGDWHLPENFSGLNPNRKDVCGSKKKNTDMPTASESMASAILCLCTPANTEKKLCEIQVNGNGKWQLGGKQEVKVVFEHIWGQWSGDGIMTECGSPSMDISFEAAKKNFNEKLEKLKSILANKSDTLHPTATKCDGSNPCAHVTENPDWLKKLKELANINLTPAPPPPQLARKETHEPPSSSTTVPVTGPPATTTPEPVTSQVPEETSQPSRLRSPEEEAKKVPLTQPGPGKTPAEVPEDKEEKKEDHVPVPGNETSSTLINGPKWPLLAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5A1</accession>
    <name>F9W5A1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000684">
        <property type="protein sequence ID" value="CCD12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32350"/>
    <dbReference type="OMA" id="GENQWER"/>
    <dbReference type="OrthoDB" id="814241at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_P" evidence="1">
        <location>
            <begin position="82"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="376" mass="40262" checksum="9C5E304B145F3A8C" modified="2011-10-19" version="1">MCSIPVVCPVSCRLHVEGSFTGAVHVLSTHVDDIHAVLELARTDAAAFHLSSSAQLGVSATGEPGRHTETSEGYGPRVLVVGETNTGKSSLCRTLTNLATTTQKCSVALVDVDVGQQGITCPGSIAAVFVENYIPVDDGFNTMMPLVFFFGGKAVTASSRRHYLDLCACAAAGVTSVAASKPAFAIGGTVVNTMGWTNGIGRDILYELLSLFSITHVVICGSDDELAEDLRKAAIGRNIIFLSYPKQTRMPPRTAAVRSAWRDEQVVSYLQGTLRTPLTSYRGIAFVKDVYFLDALTLKPMPCQDVRPLTLAAVSWADSVEFVDQVNVAGFIVILEVGKRFFSFLSPASGSLPKPFILVSDNIQLPWEKVPPFSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S6</accession>
    <name>F9W5S6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_34010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000760">
        <property type="protein sequence ID" value="CCD12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34010"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394562" evidence="4">
        <location>
            <begin position="19"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="81"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="226"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="435" mass="49133" checksum="6BABEBB45EA0D48F" modified="2011-10-19" version="1">MVIGKFALVALVFEVAFGAERPSEDEFNLFCRIFAETNDMMLEPDYVYDEGKDKEIVKEMEVLYNATTGNMDDFGKMLWKTKEFLKEHPPPTNPKNRRETHREIQDLIDKGEKIIQDNRDLASHINQKVEKAKLSVAKGIYGNHVTVVQKEDGNLTKILSNTSGIFNSNTSAKDSCGNESAGAGKTLLNDFFCVCVGEGDHESAGPCHSDLVPPRGDNTHCCKEDCDKECCEDSECCKCAWTQMKYSSENNPVNLTESLEKIEEVCRDLLGEKKETKKIPALLEEYVGMIGHGGAKERQNKTHMFGQSGWGAEDTTIEDKLKECTGSGDVGNGDWKNNNKICVDYTKNYNEGTRTYDIPWHTKFREASEKMDQAKQLKDQILKNRANLLLLKSQAWVAYNREKDDETANLDDMNVSQLFDGSMLRFPSPYLFLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5V3</accession>
    <name>F9W5V3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_34260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000778">
        <property type="protein sequence ID" value="CCD12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34260"/>
    <dbReference type="OMA" id="IAVQFLE"/>
    <dbReference type="OrthoDB" id="139272at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06974">
        <property type="entry name" value="TerD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003325">
        <property type="entry name" value="TerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02342">
        <property type="entry name" value="TerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TerD" evidence="2">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="556" mass="63190" checksum="858374A27424999D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5V8</accession>
    <name>F9W5V8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000782">
        <property type="protein sequence ID" value="CCD12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00290"/>
    <dbReference type="OrthoDB" id="1673862at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="328" mass="36287" checksum="7BCCF7E6F62B1F85" modified="2011-10-19" version="1">MNGMPSGEKSLGTSPSLKFATPAEPCVSPSRQASPNGSLLNTTSLQSTSLDVGSERLVYLGLYPDLGFGDGVSVCPPPLQRFRPNNVRCPAFENARRSNPTNQRPHTFSPGQLPPKPKDTPRGVRFDFADTHRSPSLSVNRHVPSDVKGGGRYIHPHPPPRKQHRETTYMDPRSEMSCESQLHTPLKRYTKNARLPKVQAPFSSRCSLPSSNIDRQHLCSEPRSRSLFNATQSIDESNWSRPFTQDSHPSNRRTRLGSAISTPCSTRAMGSSTNTVRRLGEIASKMANAHLSCPQIHRTPLVRSEARASPTHPREPTTLHAVYRDTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X8</accession>
    <name>F9W5X8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000795">
        <property type="protein sequence ID" value="CCD12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16725" checksum="839DDBDF1A758C3A" modified="2011-10-19" version="1">MLIVLLLLLGLVLAAEVTCTHLCHYPCSPPSAPSDHNCFFFCAVLQCFPHSFIRSLCDMFTQKIFVFLYFCFHRYSSFPPHFALSLRHSATNGIYTGHVGEVNGVVCRDDVKCLSMYKLGGRTHRIPPNFCFLSFIFFFSFFFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Z0</accession>
    <name>F9W5Z0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000801">
        <property type="protein sequence ID" value="CCD12593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13525" checksum="474A9596429C9694" modified="2011-10-19" version="1">MSSMVTMGRLRAPGFSSEGFPAPSNFSIMRRIGRIIASRQIMSISAPDMPSVRLAQAFQSTSGDTEDGVRVCLNIVARASCVGSPTRIRFSRRRSIALSRSHGVLLAARTKTTSPPRRFDRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W651</accession>
    <name>F9W651_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_35150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000822">
        <property type="protein sequence ID" value="CCD12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35150"/>
    <dbReference type="OrthoDB" id="1667371at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394714" evidence="3">
        <location>
            <begin position="25"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46051" checksum="F61F977FB7B6D0D9" modified="2011-10-19" version="1">MGMQRIVCVGSLLVAVLLSGGATGNAGNSNGVCRLNENAAGLLCTIAKLVEKAKNITENHDYKDIDETWGYVALHKEVVDHRVKNLPDIIETAKAKGTLTDKDAEHLTTLYLDAHNKNTQQHNKSKAAMDAHNKTHEDAKNSTALALGEGYVTGNCNMVSSLLGILQCYVKGEQPHSNLNVETICKEKNYNLDESQNTLLTNCNKIGNHKTYCNGTGAALKVALEKWNGMDKKKAAENGNCEVKKDWEERTKKAQEHMSRLDEHVQIIHDAKLLTTAYFAIVDKIKTGVENGKPMKVIVANAREAGQKGAKVVVGKLSIHTENDTHNTTKPLLEEEEVNVNVQLDGLKFDEDENGPAHSKESFPKIYIYLLSILLPLFCLVMGITLYCLIRKPRSSHPEKSTPVDGATMNKAGDTQAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W682</accession>
    <name>F9W682_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_35460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000832">
        <property type="protein sequence ID" value="CCD12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35460"/>
    <dbReference type="OrthoDB" id="1678477at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394718" evidence="5">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="61"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="39831" checksum="2AD9C82F2F1F4BDF" modified="2011-10-19" version="1">MMIVKKMLMMMMGVMVMSVQANVEEKTGISGFELLCEAMKVTTGAWMIGYPTEYSDEFDAKMKEFGRTINKIFFGEKGSESHFGYWVLPENFEGNNPKRNAVCGLEGGTTIMPLASKSMASAFLCLCMSTDDSPDDICGLGVEGSIKWPESGRDIKEAFKKVWGREPQEGIRKVCEGSHASFSSLEEAEKNLTASLNSLESALTSKGGVLCTEKTECDKTLHSVHVTPTPAWLELLRKVEKDIPILVEELKRRPSPDPEPASSSEILPSPTESPESTSITEPVPITSRVSQEYTEQEPRKTSEKKPMSELVQVPKSEPEPEKTIEAPQKQEEDTLSVSESETSSSVTKKPIWLFWAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W685</accession>
    <name>F9W685_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000833">
        <property type="protein sequence ID" value="CCD12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35490"/>
    <dbReference type="OrthoDB" id="1731563at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16797" checksum="18F490E3C67602B5" modified="2011-10-19" version="1">MHGTHAHTPGTSSDAGCTHTHGRVQQQDTHCASATQHVMHLQHGEETKAGKPTHMFSFLYFQYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVYREAHTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D5</accession>
    <name>F9W6D5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000852">
        <property type="protein sequence ID" value="CCD12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35940"/>
    <dbReference type="OrthoDB" id="1654493at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="957" mass="103673" checksum="2F6EE6D24D900A1D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I6</accession>
    <name>F9W6I6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_36420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000879">
        <property type="protein sequence ID" value="CCD12791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36420"/>
    <dbReference type="OMA" id="DTRGPTM"/>
    <dbReference type="OrthoDB" id="1305724at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="19797" checksum="C820D31F58FB5989" modified="2011-10-19" version="1">MASLIEKGLSTLCCITASSKPWADGEADGDAKYEDLQGPGNRNNSGSLSDKRICVPQKIDPKTFFANERTFLKWMSISVMIGMMSLTLLNFGDMSSSASELAGLVLLPVSIIFMIHSLFVFKDRANKIYMREPMRYDDTKGPTILVLVLGISLGVAAIFSVQRHYYRTASASYSDGARFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I9</accession>
    <name>F9W6I9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000880">
        <property type="protein sequence ID" value="CCD12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16972" checksum="A1189FB9975830C1" modified="2011-10-19" version="1">MIRVPFYTNGSHENSVMCDRPSRVLFPVALHVTRTRVFTVLELVVCVWKPSQWCAEVSSALISKQCPPQSAMQILPASTTAVRRHRCRKQGAQCLMFLCFVVFAWVCATGRTHQENPDHHHHHPEPYPPHLHIPYIPLLPLPYLLCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6V3</accession>
    <name>F9W6V3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_37440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000941">
        <property type="protein sequence ID" value="CCD12910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37440"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="43561" checksum="EECC9D0F092E7088" modified="2011-10-19" version="1">MLVEKPAVLFRARKSRISVYMLPLMTLLALAMVGYTLYGIGNGDHTPEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDVDGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRRRIGEGGSWGRAAEVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRASLLWTTDDIVFAAGYCTTLSKDAAQAVVSYKPLAALLRKPYSIWHMMQYSSMSVMHEDIMVGRVLREKIKLDNLVIVNVKECRFHDVPNNLERRITNNSVVLHHIGELHYFKLLRHFPTNATPPAPSPIRWVNGYTAILPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W701</accession>
    <name>F9W701_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1543</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_37780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000956">
        <property type="protein sequence ID" value="CCD12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37780"/>
    <dbReference type="OrthoDB" id="1332686at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="24"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="117"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="369" mass="40659" checksum="64D28F7C1B2BFA13" modified="2011-10-19" version="1">MHYRPNQKSPTTGNRRPYEFYSRDNLFICNLSPGVDESALKRIFSAYGEIVSAAVMRNIHTGESLGTAFVRFATTEQAQRAMEALTGSMQEGRAMIVQWAKRQHDDTPVGEARKKIVKLFVRNIPLDVGAEEVRRLFERFGAVESVTLHKDTAAASHADVGQPLRRIAFVTFVAEGVADRAAEAVHNTRPFASHGPVPLMVKLAEDHSERRATAATAAVPGFKPSSLFVPLPRFRGPQLHRKVHPQREQYSEGRRFDTLDSEICCFPVAAPRPPDAIGSVETNELTDVAVDHVAVPKPLLMMSCQADEERPGNHTGVPNSISNESSLASSQPTSAATYKKLRNIRYTHEPYRGVACTVGILPVPSQQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W732</accession>
    <name>F9W732_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000970">
        <property type="protein sequence ID" value="CCD12991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38090"/>
    <dbReference type="OrthoDB" id="1699329at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="242" mass="26538" checksum="7FDFC88290D8DAB3" modified="2011-10-19" version="1">MGCGASKPSVEHCNKSQLELEQANAQQLSCPIADDSPTPPAPEVPQASEMDTGVNKRSSEVSLSSKFPSEGASNLPYRMSRGISDADSDLRNGSGMLSNDECAASDFATFSHKGYRCLYCHREGDVGVCNSSFPALVCEDCSCHNGWEQEAGQTSDNIQTKTNGSNAAEEHSNKSEGFRSSFAGTACEHRNVCDDQYERCSRCTRQRRRRISRERICIRYTSEAIYVDDVRCSHTRTGGFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W797</accession>
    <name>F9W797_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1587</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001004">
        <property type="protein sequence ID" value="CCD13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38780"/>
    <dbReference type="OrthoDB" id="1710305at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="54"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19442" checksum="D6FB78C99BD92217" modified="2011-10-19" version="1">MGHYGALSSEPLMTRGRTWVCVYTQNEFANAGYQPAEAFRVKVHWEGLLPVQGEIVVVEDDPTLRLLMVEIVSELGATVRHFDSADDAITYLLQAHEKCRMVIADHGVPGQIQGTEFVGMVKGRWPSIEAILTSGYALDLTTIPSATIYLHKPWSLDELVLSVAALLQPGRPLTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7R9</accession>
    <name>F9W7R9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1646</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001071">
        <property type="protein sequence ID" value="CCD13241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40100"/>
    <dbReference type="OrthoDB" id="1657174at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="702" mass="73944" checksum="55CC850DDB5986CF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W826</accession>
    <name>F9W826_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001124">
        <property type="protein sequence ID" value="CCD13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="15196" checksum="350F8B2AE06D3A63" modified="2011-10-19" version="1">MSGKGKVRQEERGESGKCLPWNCRFYLSGFLFSFHAPPLVTLGDDNNEWGTFQLTRSYGKVINYVEKSPVFSPPFLFYLFLLYFFFFVVVVCVRRPRVFKELMVVVVVGVAAYRCLPFYCTFLLAPLPPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W852</accession>
    <name>F9W852_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1707</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001138">
        <property type="protein sequence ID" value="CCD13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41360"/>
    <dbReference type="OMA" id="VQPHLCH"/>
    <dbReference type="OrthoDB" id="502636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="456" mass="49756" checksum="61CAF078FE52A624" modified="2011-10-19" version="1">MAFEPMAMDTLRKIVSVKLERLSAAGDETQDGFVSSWQPLRFKLTAALVNEDGQSDRGVMALMAAAGESDFRLLWHRLFHVLRITPSVTHGCMEQKSHEQNGPHDLGCLPHRATRNRALPPDTAGITGEPFTVTAMGMHGGMAVAPVTTTLPAAAENAGRTPDGSTGEIPTHMESVYEFHYFLPDVGGFQDEIVVSFTIMTQFFDESAAEIGHSLVSAGGRTGLLLGPASLALGVCHYRAGVNQPLRCASVSRRVTDICVLSCLTVTNNISAPVEIREVAFDIFSTRVERPHDRGAIGSRSPEQRLGPCGTDLRALKLLQRAISVTPLLLHEHCLPTTLQPEESICFQFTIRVQPHLCHLFTPVTATRRFDASQGETTNGEREPTAVWRPSCVGEAERVPCGELRQVLSQNFTSYLYLHYNPLGAARDGSPNEAASAHHRTIRHPLNWSLLAPEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W881</accession>
    <name>F9W881_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1714</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001147">
        <property type="protein sequence ID" value="CCD13409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41600"/>
    <dbReference type="OMA" id="LRIYETE"/>
    <dbReference type="OrthoDB" id="1183644at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="1">
        <location>
            <begin position="127"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="35681" checksum="183D57D1C5109C27" modified="2011-10-19" version="1">MFQMTPSTSFSGRQLWNSTKLIRENRNVRRSHGACVVGSAAAVKRAWREYKIRPNVVYVPDTEPTVASWCLEEDLPTCVVRCSPAEINRRLLSAELCDGYAAEFPTPTAPLLEMFLGEGKPTRLASMLVLVGLRIPSNVGVLIRGAVDMGFESVLLIDCVDLFSEKVLRASGGTAFSPRIKVFEASGDAVSLLSNVATEHHLLPLLAVPSQMAEPAFEVAKRFHASNAMRRAQSNSREAPLHVGPLLVLGSEAQGLSALTGGWTIPHQYVSVPLPNSTIDSVNVGVAGSVLMHGFRPAAEKKFVELGEVQQAGEREGVAFPTVTPLVSVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8A9</accession>
    <name>F9W8A9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1722</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_41900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001156">
        <property type="protein sequence ID" value="CCD13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41900"/>
    <dbReference type="OrthoDB" id="1697866at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="14"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="236" mass="26392" checksum="89A1E64D31B5670A" modified="2011-10-19" version="1">MQSNYYNNHDNSHHNRLCLCGTYGDKHYPGESVRHDMLCLCTPVPEGPTEGTNDELCGRKTGGLGAAETEGPRMGFGPNAESVKKTWEDIVQSCLRYGVRKGLKNLMEEFNKEVELKKNRLGGEMEDNPTLCGGNALNNTCVNYAGDRPGAESVCARSQTWWQRLYEAIKDEPPEEEIENKQKAEKLEKVETNKPSENNPEIPKVKTLTATTQTTSPGSGTLINRNQWPLLIFLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8G0</accession>
    <name>F9W8G0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1734</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001169">
        <property type="protein sequence ID" value="CCD13492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42380"/>
    <dbReference type="OMA" id="NYICKPM"/>
    <dbReference type="OrthoDB" id="176683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="992" mass="109489" checksum="567385199CB0C2C9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H2</accession>
    <name>F9W8H2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_42500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42500"/>
    <dbReference type="OMA" id="YKGRCAI"/>
    <dbReference type="OrthoDB" id="321721at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="10"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="590" mass="65071" checksum="0DF177E5CEFEAA3A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8K4</accession>
    <name>F9W8K4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001175">
        <property type="protein sequence ID" value="CCD13537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42820"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19829" checksum="C15FB06CD6AA6865" modified="2011-10-19" version="1">MSQSPSSPSPEGMAKTETQWNTEKDVVEVLLKGLGDPKKINLYPFLQPAYPWMHSYVSRLSITDFARNTWRCVGDADGRENVWESFPRLLWQLRVLALKLVYYAGSPEGWGPREWEVWREFLKLDETDHDIMGGMVWAVSRMPPQTRGFLGAPYPTGYPGPIPMPHPKEPGPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8U6</accession>
    <name>F9W8U6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001220">
        <property type="protein sequence ID" value="CCD13632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43700"/>
    <dbReference type="OMA" id="FEDWERM"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="25602" checksum="65B5F01F6BF35231" modified="2011-10-19" version="1">MLVASIKASKLREILSGALEKCADLFEIAGLRAFLDKTTVHTLVRHLEHLPRGNEAKRESVLSQRHGNGRVPTTLFEFASDSPKRELETGCLYKPLIPNFPLVDGFFVVEGKGPKTIVLPQITKAKEHHTKKTTVREFRDYMGKVFEDWERMEGGCSWEIIYIQHVDSAAIKKRQQCASSRYAANDTDLALWDRIHQYQVTLNSDIASEFISRSSDPREVQSASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8X3</accession>
    <name>F9W8X3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1792</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001233">
        <property type="protein sequence ID" value="CCD13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43950"/>
    <dbReference type="OrthoDB" id="1718663at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008813">
        <property type="entry name" value="Plasmid_replication_RepL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05732">
        <property type="entry name" value="RepL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RepL" evidence="1">
        <location>
            <begin position="79"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20268" checksum="72B68E32FE49EE35" modified="2011-10-19" version="1">MNSYNNEAINDAAEEAAAAVAQGLNTLLDRENEKPNGKGPVKTKVSTKVELDKEKSLKEGTKYFYGFSTNLLKLDLTPTEFKIIIHILETLKWGNVVAMTQKSIATKTNISPSVVNRNWKSLIEKNVLIADEDGSIYLNTNFFFIGLYAHMDAQRRKDFEKASGYNDNITHMHNSPGTQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
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    <name>F9W8Y2_TRYCI</name>
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1798</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TCIL3000_0_44040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001239">
        <property type="protein sequence ID" value="CCD13668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44040"/>
    <dbReference type="OMA" id="IVREYWR"/>
    <dbReference type="OrthoDB" id="1111987at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="839" mass="94002" checksum="8D409C106C686892" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I1</accession>
    <name>F9W9I1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1866</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001315">
        <property type="protein sequence ID" value="CCD13883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45720"/>
    <dbReference type="OrthoDB" id="821308at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="2">
        <location>
            <begin position="251"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="531" mass="58707" checksum="1F61EC816954A626" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9S1</accession>
    <name>F9W9S1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001341">
        <property type="protein sequence ID" value="CCD13976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46600"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1079" mass="132527" checksum="A2EE92670C54F0CC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9S8</accession>
    <name>F9W9S8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001342">
        <property type="protein sequence ID" value="CCD13983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46670"/>
    <dbReference type="OrthoDB" id="1727925at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18141" checksum="807B1989A7E3512F" modified="2011-10-19" version="1">MLSLPGGAPKVNSLESHFNSAVVKDVEGFFFADLCKGICLLLFGQWTPIAHKSLRTQWSVACSAFAKFQLAASVVSSLTLFLFIMLKYVSLRALLKTHISTTLLSYWFTFSNFFSRSSSSRVQKGVNPFPFCITILAAVRTADKVVQFNQPHSSGNFRTTLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9X9</accession>
    <name>F9W9X9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001363">
        <property type="protein sequence ID" value="CCD14034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47140"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001995">
        <property type="entry name" value="Peptidase_A2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50175">
        <property type="entry name" value="ASP_PROT_RETROV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25980" checksum="5EFB25199887F578" modified="2011-10-19" version="1">MVIGATGSKFYPWTTERALQINKNIVTHSFLVIPECPAPLLGRDLLTKLKAQVQFTSEGPQVSWGKAPVACLVLNTEEEYRLHEEQPKNAVSSGWLTAFPNVWAEQAGMGLAKQVPLVVVELKADATPISVRQYPMSKEAREGIRPHIQRLLDQGVLVACQSPWNTPLLPVRKPRTNDYRPVQDLREVNKRVLDIHPTVPNPYNLLSSLPPERTWYTVLGIKRCLLLPALAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Z2</accession>
    <name>F9W9Z2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001365">
        <property type="protein sequence ID" value="CCD14047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05030"/>
    <dbReference type="OMA" id="WNAYLAC"/>
    <dbReference type="OrthoDB" id="482151at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="593" mass="66389" checksum="82E5171D8A0A8F2F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA54</accession>
    <name>F9WA54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1938</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001395">
        <property type="protein sequence ID" value="CCD14110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47740"/>
    <dbReference type="OMA" id="CAVANSP"/>
    <dbReference type="OrthoDB" id="808873at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37245" checksum="87D30F20398BB676" modified="2011-10-19" version="1">MTTSVIPAVGAGVPLRVLDCSLGAMAHALPRRWLTSDSCQSVARFALDIITGGIIMAGATETLVPLSLVDALHNTYDDNTPGEGPQNEMWGSMEKYRQFIIFAAPRDVPKLIRRFPQYKKVCLCAPSGPLASRMLFGKYFEEFYAEELNPALYTLADAGDYKCTVWLRSSLTCRYEGLYVPPIRVAETAARLLSCEVPGASGSCSCERVVLEEGVCGLTPRWLETAIKTASSCGIPINSIMLALCRGSVGSQSENYLLSKVIRMGMVSVAASSVPAPVFPETDELLGIDDIHTFSLGWNDAYGGRVSAEELESTDDCVEYCAAVRERWLRWPLLTRSEEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA86</accession>
    <name>F9WA86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48020"/>
    <dbReference type="OMA" id="GPANQNI"/>
    <dbReference type="OrthoDB" id="1669926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394633" evidence="5">
        <location>
            <begin position="22"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="25"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="155"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="423" mass="46190" checksum="E446E00CD704A8DA" modified="2011-10-19" version="1">MGVQNQVVFGLLIGMIFCAACVSPGNTNRPAFLALCNLIQLTEKEVTLPAFVNTPTDLENDLIKLNMTTAEDNWYNLFPGNGESVWEQVKSEEKFKVFAGEEDTLWAQMYEKWEKAKKELLAESAEEGPKEFARPPAGARRTIARVKIQRMWRFYEDTEKKRSGLKEKLEAKKAEIEKAFQLARAGTETGSVTSESFNTANRSTACGGKGADATGKSLANDLTCLCSATSIQYAQNVCTDGLPGQLWSTNDRGSERTDAYTAIKKVCDAEAVNDLKPTAHTIEKLLRNFTGLLGKGVAEGNIAPYVLGGNIVASGSCAGGYSAQICVNYRKSFLGEAEGIPWFKQLEKAAELLEELDEEEKEAHALNARGESLRDAAWVAYEEVAATELKNIAAGAGVRGGARIQRVFATAHFTLLWALPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAF8</accession>
    <name>F9WAF8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001429">
        <property type="protein sequence ID" value="CCD14220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48670"/>
    <dbReference type="OrthoDB" id="1665286at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394807" evidence="5">
        <location>
            <begin position="24"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="19"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46025" checksum="36D3382B702A7E2D" modified="2011-10-19" version="1">MFFKNRILLETALLSGFLLQVCGQMKEGSNAKQYGILCDIYNVAANPPNSLYDTNKVEKITKEIYIIDASLSDDSWLSETSEKDTNGNVTGELKGNNSNGASNWHELKHDVASAASNYTGFQNILSTKTFVSRAQRKLKKIVSQMEKVIKNVQEANTAANLDGIKKDFETVIGKIGEQTTKEDRVALCGNPSNNKAGTSAGKFLILDFLCLCSRPCISDNLPNVCGPDIKENRWDKTTGDGKSDEKGEETWKILKEGCENRGSTKLADPNAGYVALGEFLTAVSQDTVTTYKDKPGIFGSVYNQRGSGPTGGCTGRGGEGHGACLYYGNNGKDGGRNIPWVQKFKSGLEKLKKFQNITASVQSDIMLLTMLQIRAEEIYEDTKAILELEKSNHEEATTHSAALNHRYHISLFFPWSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI4</accession>
    <name>F9WAI4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1977</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_48950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001438">
        <property type="protein sequence ID" value="CCD14251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48950"/>
    <dbReference type="OrthoDB" id="1675828at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="8"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="32538" checksum="3D6C74303EAFE6F3" modified="2011-10-19" version="1">MSAAENIEKAKPEFAQVIFGDGGNESDLEHTALNGVGYRVTACGKPGQDTKGESAGNNLAVDFFCLCAQRQDGAGINQVCGFYVGSNRENGQLCRSGTRGPMGSSTMSASIKGCCGKHMQKHPKSTTEVRHILDQFLKHLKTGGVYRWGDSGDKVDGSKRKAAMLGAGVRKKNGSENGPVCDGKKGKSQSSVGVCVYYGTESDGKNISWAIKFETALARVDYVNNNTDSIQRALHKLQMLLHRAEQIYETAKVITEIQRPAVPKAFQNESVNLTAYNAMRTRSYSRRAYIIPLWALFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAP3</accession>
    <name>F9WAP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001464">
        <property type="protein sequence ID" value="CCD14314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49480"/>
    <dbReference type="OrthoDB" id="1666787at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388915" evidence="5">
        <location>
            <begin position="21"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="17"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="99"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="424" mass="45920" checksum="9B653498C3D71DB4" modified="2011-10-19" version="1">MACIMKAIAVAIVVGSVVSGQKELEIDKDENIEPFSLLCRIYNVARNPPINYVDLQEADTIVEEIDVLNTSLVEPKLHNETEQMGNGGEAMISPAAMRETAIAQISLNQITQKAHTVLDEINKMDAAKEIENAKAEFNKVIFGENGNESELDKGALSGVNGRTTACGSPGGGAKGINAGKSLVVDFFCLCARNPEEQGVNQVCGFYVGVKDSKIGWNESDPMGSSTMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLKTGGVYRWGNGKTIDGSERKEGMLGTGVGNKEDSGNGPVCNGKKGGKLPSSPGGVCVYYGPKSDNWEEKIEWLKQFETALASVDAVNNQTANIQRSTRKLQMLLQRAEEIYETAKVISEVQNPVSLPAAFQNASGNLTAYNATRTRSYSYSSHPHFILLFFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAS4</accession>
    <name>F9WAS4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001479">
        <property type="protein sequence ID" value="CCD14345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49750"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23985" checksum="29961D0AC76D8F3B" modified="2011-10-19" version="1">MHSFLNINTTPISTLSYLSFFPYPFLSPTLIGITMSESPSSPSPEGMAQDNTPWSMEKDVVEVLLKGIGDPEKINLYRFLQPAYPFMHSYVSRFSLRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMIWAVCRMPTQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT3</accession>
    <name>F9WAT3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00580"/>
    <dbReference type="OrthoDB" id="261724at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="504" mass="55930" checksum="4354313CE35569C3" modified="2011-10-19" version="1">MNGPVELCSHNANTVSFLFCLEDPGVYFCSPVSARVRIGAICLNVEWRFDETSIERHLSQMLQFQNCRYDPRRYLPFVCLDNLANHIELSVPNHMEGVEGESLTLDVVIRAESRLNGEGIIAFSCIEGVYESAGCAMDNSCLQEEGNPAKGYVYFALDNVLHVLSEGGLRLKMKYNCKKAGKYSVSVTFRLYSVMHMDVEITKTVQVHICYPFVLTYTLFKTLPWRIQQKCSNRNATDFLHIVPEVSTALIQREIHTLVRPQEYVNHDANALREVKDILLYNVFTNKEKRDDINFFQGEVVVVTMSMECQCIQGVTLHSLEPIISTGTELVSVTAGPLPCHIEYMEVFTVTTKLRVLKTGRLLLGFVQMLLSPGSSTQRIASGFSLPEIEVESSTLELTVKYPPTATVGSHFTMTCEIVNKTAALQSCQFTMEKSNAVGLISGAENWNVSIGPHAACETSVVLRPLTTGVLQLPSVSLKHSSGGSFGSVAACQFHSQKICVLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV7</accession>
    <name>F9WAV7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001489">
        <property type="protein sequence ID" value="CCD14379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49970"/>
    <dbReference type="OrthoDB" id="1709451at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21206" checksum="756EC31CF0CCC291" modified="2011-10-19" version="1">MSWYTITSTRTIPWSMEKDVVEVLLDGVTSPDHVNLYWFLRPVLACLPVDLVCFTLGDFVRNPRHCIPEVNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPCQGVVLVEAAPAFIQVPYSTVGYLVHLPVTTRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAY0</accession>
    <name>F9WAY0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2030</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001497">
        <property type="protein sequence ID" value="CCD14404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1686745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="29428" checksum="086C5A21BB35916C" modified="2011-10-19" version="1">MQQQLEHLQGIIAQQAAQLEEYVRTDATLRQQLTGQGVGVHTEEDERHHGKQDTGNVKRMDEYAWKGFPPHAPRPSSGGVGIRGIKELQGNSWMSGVRPEYKYSYISECDMEYLEDRNPEQLIAAYQYMSPTAATPGPAYTEAWKNFVSWALGLRSEGISEGHLQLGRQLYNQLRTIQTVKDHPGVKIEDIRESVEYPHRKDDVFIQAALKAKRHQTAIPPGRAQCFTCGRVVHYSSSCRVSKKKPESHPTNGFRPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB54</accession>
    <name>F9WB54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_50940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001534">
        <property type="protein sequence ID" value="CCD14485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50940"/>
    <dbReference type="OMA" id="NDQLHEE"/>
    <dbReference type="OrthoDB" id="1672844at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394825" evidence="10">
        <location>
            <begin position="27"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="18"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="318"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD14485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="390" mass="42138" checksum="B78B01DFA1C6BB5F" modified="2011-10-19" version="1" fragment="single">MFMELRSTWWLFLASVILSLQNTVWGNSQKAIPTKAGAAICTLSKTLKDVTPWATQQVEDGAAKITHLEMKLLEWQSKFIQSKSKGSGSEECKITGLLFRQVRKEINKARTEVEKLEKEASKAAALAANSAGRLEEFITVFANAKGESNSNYCLGDSKPATNEELKDCFGGKDLSEESLVDIGEKASDKELNLNSAIDSIKHSKLSSHFSGTSSTNAGCNLIKGDTGGILKSVGLEKSLWWGGGILTIGKDFAGDLASITAGEIPNATVSKATWTADPAKQIVHLKNASDAFKAFKAVQEKIKEKVESIEQKIQACIGGQESGENSTEQNTTEHTATTEQTTTSPTCFDNVARIAADLKEKRALLARYQKVKGWIPPSSAFNAKNPSTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ5</accession>
    <name>F9WBQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001613">
        <property type="protein sequence ID" value="CCD14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52830"/>
    <dbReference type="OMA" id="NWIAKCH"/>
    <dbReference type="OrthoDB" id="1655556at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="700" mass="79196" checksum="FF6C98376BA5C8B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU7</accession>
    <name>F9WBU7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53260"/>
    <dbReference type="OrthoDB" id="1657867at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="616" mass="70170" checksum="7ED38C67E6E09309" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC29</accession>
    <name>F9WC29_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001661">
        <property type="protein sequence ID" value="CCD14817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53980"/>
    <dbReference type="OMA" id="YHTISLH"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="211" mass="24736" checksum="29C71F36A59FC34C" modified="2011-10-19" version="1" fragment="single">MPLYNTIALYHIIALYHTIALYHTIALYHTIALYHTIALYHTISLYHTIALYHIIALYHTIALYHTIALYHIIALYHTIALYHTISLHHIIALYHTTALYHTIALYHTIALYHTIALYHIIALYHTIALYHTISLHHTISLHHIIALYHTTALYHTIALYHTIALYHTIALYHIIALYHIIALYHTIALYHTIALYHTIALYHTIALIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC47</accession>
    <name>F9WC47_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001667">
        <property type="protein sequence ID" value="CCD14839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54160"/>
    <dbReference type="OrthoDB" id="1701535at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="23657" checksum="5BCA0F3FDE2A32F1" modified="2011-10-19" version="1">MAVKAPTTTVPKTIALRRATAVRHIGRKLKTVSNCVSKRLVEYEQKFDDVNKVRVIVLNKVFMQGGHNLNCGKESSLLPYTQERLVALQQTMEQNREAGTMAAGSAGISACGLDEFMSVSKQNTRETSDRNFPATCYKGNDNNDTKDATDTQYGDGVEGLGKCVDAQFSLRNTQGGRIGNNCTLANMKNDGGYVDKKPFTTISSGEWNFWIQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC70</accession>
    <name>F9WC70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001677">
        <property type="protein sequence ID" value="CCD14862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GNLGMPN"/>
    <dbReference type="OrthoDB" id="884222at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="385" mass="41793" checksum="D80E5C6A95C6A408" modified="2011-10-19" version="1">MQVTLNFSFTQPHLKHQSRDVAVTMHVPVPTQRPYAAANLFYMCTGTLPPPELLPETATLTLESAQSVAGLKPFADSAVVRIERDVVMEIGSSTTKTIFGGFTKDEFLNAGEYPAVQQNIIAAMQKLPAGTVLIGNXGIPHSNGTATRLAAGCRGKRRRGXXEFRPYQPLGLVTSGLQALQEACAAVAVHPRTLVPVHKVKMSASGIHFSLNPSQGAQSADKMTRVAVTRTAGRTRCREEFEEVGAEREQLTESNTSAFFDQSRKFPTGPSEGHSSAAAQPQAKRLRTERVVTNEDGKVALRTTAVECAEGEPFDYMAAQEAAFLNDIDLISKTQALRHSRHSHRQQKKQRSSNGGGKQMPGKAGKKSARPASLPNGKKTLQRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC79</accession>
    <name>F9WC79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="LEEANGC"/>
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    <dbReference type="Proteomes" id="UP000000702">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="540" mass="56848" checksum="B68291FDDD539D26" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>F9WCC5_TRYCI</name>
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    </organism>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54870"/>
    <dbReference type="OrthoDB" id="1801420at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="18851" checksum="34F1CEACD7165E99" modified="2011-10-19" version="1">MFYGRLLQCNRHSLYLHIYPTYHHYSKRTHGFACCCSHSTFLPVFFCLFLLLLWWWWLTFPLFLFYPLPVLERFPPSFLALLLLLFACFSLSALFSCVYFFSIPREVSFHSFRPVTYVCKRRQRTELVNIIVCFYFYIYYYHRCHHHHYVCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCI4</accession>
    <name>F9WCI4_TRYCI</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001726">
        <property type="protein sequence ID" value="CCD14977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="80"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13610" checksum="575D10E94F8FF125" modified="2011-10-19" version="1">MALPPHTASNIDNTAAVTFHYFSLLLLLLLLLSLPLLLAPFPLLFLYLCFNYIFARGTFRYLLFFFFLLFLCFSFLFIYFPSYIFVCNSPSASTVPLSASSEFPFFFFFFFAFASRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS0</accession>
    <name>F9WCS0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001753">
        <property type="protein sequence ID" value="CCD15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="13842" checksum="157114ABF3F826B8" modified="2011-10-19" version="1">MSCVEIVKPHRVTHSSAMGFPLTSVPRRCGCSSMKSACNKWAALALSHRTHAWPSLLSSLPHYTTGGFLCCRGAQPKSAGTTHPSLLPTLHTPFSAASSIQLLTGISHGAVARPCSSTFKQIAFQVVKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCU8</accession>
    <name>F9WCU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001768">
        <property type="protein sequence ID" value="CCD15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56580"/>
    <dbReference type="OrthoDB" id="1689981at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="263" mass="29557" checksum="BBA356DF41DEDF9E" modified="2011-10-19" version="1">MTWLPISLKNAAKCDKWYQLQNHHIAQSLNANGAWEKLFRVIPVHATFSVSTNKKTTAALFFSLSLMMSRVCGVCAVCSRDVFENGVRRVRVPSSPINISCRQEGESPVCVLWCCYVRVRRVVCGMCVEVWSLWHEGRVCLLWGGVLLHFVPLETRPLSRLPSFPLRVIIAASFHPCRSRTPPLPPPVFTSKLFELKRQSGDVAWEGGFLPSSAVLTPHCGTGVCMSAHPQEFIYVYMLTDLSVAGPPAKLKHITQRRKRKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD04</accession>
    <name>F9WD04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001798">
        <property type="protein sequence ID" value="CCD15152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57120"/>
    <dbReference type="OrthoDB" id="1268130at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394884" evidence="1">
        <location>
            <begin position="38"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="39820" checksum="36DCBB44E4D9B0D0" modified="2011-10-19" version="1">MHFHVGKVVMHPSASQLVSHFPLFILLLSLSLPTKKAKGVLNKAAASHAALSLTAEVRHTQWRVMQSTKAKVTKQEQHNVPVTLSTSSSASVYLTTITNRIAARHGVSFLILKPVEYTGQTKEPQESIKNSMKGAIAKGSTNNPQAMEKFKQSAEMWSAMWAQPSGSVGSQVQTQHRVRPILPASLLLLFSDMGMSKPYEPLGLLGLLKPEDEVVSRCFRGAEARQSPLQPVICIYLNALESIIEVTDRLSAQAKAMYCQIYRENALKRGTDVANHGGNSTKSADNSPEKCRSRFFLLTPSAPYAALRETANRIVNDEDTGLTGTGTSLGLGEACEILLVYDFNHSSHSFARDTPRSAIQRCGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD25</accession>
    <name>F9WD25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_05890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001810">
        <property type="protein sequence ID" value="CCD15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05890"/>
    <dbReference type="OMA" id="RRIWDLT"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="108"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="474" mass="53203" checksum="4350077247BF46BE" modified="2011-10-19" version="1" fragment="single">MCEARLKPMNEVAHRRALEYYLRLKAKGAAHAKLAESIFPPEHPIRVRLAKVKHLYSTIDGMGKQHDATVLQLARRVHFNTTTPGGLKADAPEKDKKMHTMRRVVRFRDFDYQVWTDGSVVLDVSSGAGALVYPKEGRREKVVLGAGSLARSYRAECVAMEAGLKRLVDVIELNQTHRTRVVAFTDSLSLLMALGTGPSVVEDAILRRIWDLTLRLVRLRVSVNFQFVFSHCGVPRNEAADKAAEQGNAKPQMYPAWITDIVAAVERQIRNEMYKDFEEGLRPRTHRSVLLGHVRPAPKHTKLGRLGESLLAQFRTGTSRHFGWLHRVLTRKTDRLECRWCRVQDIGCDAVKGHTLAKSAVDSANAPDLGIATRQSDPIICPLCHMVCARRQAGVVHLVKIHRLERECALAMTKKARRAALTYKNGCTCHVCGDAFERRGLLVEHMAQHPPDVVPTVEERPKGAREEDEADDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD50</accession>
    <name>F9WD50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001820">
        <property type="protein sequence ID" value="CCD15201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16386" checksum="16072BC45FB26A1D" modified="2011-10-19" version="1">MESMVEAFLERARDDWGAMNAWNFFSHYYGNPYGMHRHTAVTMQQYLENPDKFVPDPATREYIQLNLKLKRALMQKHFQRDLDKLKAAGIVSLDEWQRLGATVDMGPMARMVLASAYQHALHHSPPKGILKKPTPKKAEKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD71</accession>
    <name>F9WD71_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001832">
        <property type="protein sequence ID" value="CCD15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13842" checksum="9C76D687D65A672A" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMSFLVFRHLARCKTVFATIISCFSVSFLVFRHLARCKTVFATIISCFSVSFLVFRHLARCKTVFATIISCFSVSFLVFRHPARCKIVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD83</accession>
    <name>F9WD83_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001836">
        <property type="protein sequence ID" value="CCD15234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57760"/>
    <dbReference type="OrthoDB" id="1679832at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390172" evidence="5">
        <location>
            <begin position="17"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="326" mass="36147" checksum="B381DFC551F4A7F7" modified="2011-10-19" version="1">MKFLFFLVVVIFGVAASEDETNHNGPQHKALCDLMKAAVGKWGDGGKGLSEPMSKALNRTIFGKEGGGDITELRKQLPNFYDEVLEGNANRFMSCVGRQSGQSAPYDMVCLCTAGEKGWPLSESGIGALCGQPKDTLGSGNEGWSDEERKKGEKGLNATWRNVVTPCLEGGIGKDLKEALETFKGKLVNKSDEFLPDMYQLGEGKPDHNGACTGSKKYGVCVMYYNGTKTMDHRPWWVDLQNAIPQEEKFQEKKKKREEERRKQQEREKQDIPQAAALTSAPPTNNQTDQQHNKANLTTQFHRLNMTSGTLISIPTTWLLTTIILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDG0</accession>
    <name>F9WDG0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001863">
        <property type="protein sequence ID" value="CCD15313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390213" evidence="1">
        <location>
            <begin position="32"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="12797" checksum="4407045F7FA2F411" modified="2011-10-19" version="1">MLLPRNDTIFLAALMLLPLGALLFCPPGVSCVGAYEERKAYRAHTVRCALIVAWVMKFDGVVVSGKCPVTLEVIAACVGPSCWRAVSLEAPITGNMKVVLGGGRRLILGGIVEWVDVDPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE13</accession>
    <name>F9WE13_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001936">
        <property type="protein sequence ID" value="CCD15518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60240"/>
    <dbReference type="OMA" id="QERFTHR"/>
    <dbReference type="OrthoDB" id="1659206at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="592" mass="63392" checksum="9FD1E3CAECB952B4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK7</accession>
    <name>F9WEK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002031">
        <property type="protein sequence ID" value="CCD15718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="37762" checksum="FB301976F199C150" modified="2011-10-19" version="1" fragment="single">MNRGGDILDGFFVSPGISLNQGGGSSASWGAEQQQQQALQHQRRPLPQSSTTLQPHTPDISIDVATTSVCSSTTNNGEKDTPGLPKGRGDADYGKMVLEPTAAELGLNGNLDRVGRGNRNSRGDAADNGKSAGDYIRAGVESGIKSAVPSAASGNESYVPLGSQYLFDVDQRMLPQAAHHMQPNIQAQLNATSPPSVDPMGESNVGSDAGLHCGDNMLEQLLSSLEDSRERAKSFLMHLMGVAPLATPVAATLSQLVANLEEGIANIKQSRGLFSLGTMINEGAALRGMGGDVPRDSSHALAQQAQPQQQRYRPGVADVPLFTGSAVPVRYGDRGAWHPPQGRGPNGECGSTMDIGCPTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEL3</accession>
    <name>F9WEL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_07360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002032">
        <property type="protein sequence ID" value="CCD15724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07360"/>
    <dbReference type="OrthoDB" id="1667565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394949" evidence="5">
        <location>
            <begin position="25"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="115"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="410" mass="45271" checksum="7E1B1D89C2E6EF79" modified="2011-10-19" version="1">MLLNSAFRLLICVSTVSLWLHVCAENLNRREYRAMCRIYRIALRHHNDSASAYVGSQLDWKRFDELYERVKACVEATGNTTEGEVELETDFGSVKLPSGPVTAKAHNICVAGAGKMDHINKAAQLLKVNAEDAAQRAIANLKTAITTEKNLENAGQEPRGWNDDAARDATCDSHENGGRAGVQLTTDLICLCIGMYYNTHKACGTGIPGHGGFRASQKKFSKEKDHWADIHKDCDKMSVKDDFTIENINTSIENFNALLGAKPGKWSTKTKKSSWVLGHTAEAPSCRTNETKRWDKNICIDYGLSDGSLGEIKWRSQIYKTRNFLLEAEANIAKARKLLERMEFLLVVLEKDLLLANISNSLVLAAGLKTVRPHVSLKSFGGTGLQESGGGGSRHYLALMGVLTLMFSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER7</accession>
    <name>F9WER7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_07940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002056">
        <property type="protein sequence ID" value="CCD15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07940"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="117"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="366" mass="41592" checksum="C7A41864C4FD0540" modified="2011-10-19" version="1">MPHGVSCMHTGLGCKFCSFHALILDALEMLHGSLLVTGLLAYIAMLATSDMENEHEKLIFCLIRLMAEREPKELVFRNSVEESEIVSRIKQLNSSVMNFHRMKVGGSERRYVDKRSKEYGREIHKILEAALHLKAEADAYKLQAAAKRDSARANLKRVIYGDAMNFTAEDTDIQRRIDDNTSKENVFQNIGKPEESCSGRGAGRSLINDYFCLCFTKDHLGSNEKSYRGVCGDGIVETSWDDTKEGWLAKWHKNKDKGCERFQGRLPSPPLIEEALYLFNKTVVAIHAKYHERDVLGHYQPYDREKKPVPCMSTTYSNACVDYKHVLSHGGIPWVNRLQNASEDLREMEDLVSNLKYSYEAGATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF24</accession>
    <name>F9WF24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002094">
        <property type="protein sequence ID" value="CCD15892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="IEEPLCG"/>
    <dbReference type="OrthoDB" id="964725at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15511" checksum="4BE8A29C07206DE4" modified="2011-10-19" version="1" fragment="single">MRHYVIGQLVWLAKVTIQLLIAMGVGVKWVFMTARLVLFVAVSFSYFLPFAWWYLISPNIIRRVAYRSSRRTKRRNLEMMFKRITEKRMNAKRAEFGNSLRMEEVMGPDAMKQLASALWLPSNCVSQVGASFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF96</accession>
    <name>F9WF96_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 362</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002117">
        <property type="protein sequence ID" value="CCD15964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09500"/>
    <dbReference type="OMA" id="ESMANEM"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389055" evidence="1">
        <location>
            <begin position="21"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="750" mass="81760" checksum="F4C13B8CA58D262B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFE2</accession>
    <name>F9WFE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002132">
        <property type="protein sequence ID" value="CCD16010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15121" checksum="7AE80BA0B0B90860" modified="2011-10-19" version="1">MVIQKCAAASTMSNEGDRTSPNPRPISLLMKYSLSPLNPHLTIRTSHHPKEKREVQRVLPLPLDRPCHSFFLIMGCALLRAGLANCREPFFPSQSCASPFINSLQEPPCFVFGLVLVLVLKWECTPCDQWSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFV6</accession>
    <name>F9WFV6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trypan_glycop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_11350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15661" checksum="662EF99EDE4570AE" modified="2011-10-19" version="1">MKLLEWQSKFIQSKSKGSDTEACKITGLLFRQVRKEIEKARAEVEKFEEEASKAAAFAVNSAGRLDEFITVFANAKGSDSSYFCLGDGSAAKPEDSRDCFSGTDFREESLDDIRESASAQEPNFFSAIKSIKYSKLSSHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG25</accession>
    <name>F9WG25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FUN14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002222">
        <property type="protein sequence ID" value="CCD16255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="YIQVNWK"/>
    <dbReference type="OrthoDB" id="1431148at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21346">
        <property type="entry name" value="PTHR21346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15592" checksum="DA09131AA8D5770A" modified="2011-10-19" version="1">MSVRSKREDNNSPERKEKGEDDFIHKLPAFYPRLSKEIGMSSILGAAVGVTSKRLTSDALYGTGLAIIILQFLNFFGYIQVNWKKMESDAVKVIDKDDDCLKRVDVNTFFQRFICFVGKGVGDISGFMAGFYVGARYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG43</accession>
    <name>F9WG43_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_12240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002228">
        <property type="protein sequence ID" value="CCD16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12240"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394747" evidence="5">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="35"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="37540" checksum="4779EAFCEEC554F3" modified="2011-10-19" version="1">MFFVFMAMVMMGLSGSSLGTGTNEHHNHNGDNHDDLCSVLKAAVTLYHSRRSGEKLRKALKRAIFGNESGGGDIETLQKGLPETHNNPGNRKNWCGDCTYGGDHYPGKSIPHDLICMCTVGSSGFPFTHMSENGKTLCGKSATDLGCEKNRESGTGCHGKNNSHWWNDTSTNHEPNGKGQVKEHLETTWNTVVKPCLQGRHIEQAKKTLLEKLYVGHQSSPSWARGHTNCGGDHSDVCVSYGHQCHDNPNSPQWWQELYDALTTTEDTSAQGNSTRSPRKRTRRKTGSATAAGEPEDDSEEDEPENTGTTSTSNRPLPLLSNQQSGILLTKPLLCLLSASFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG58</accession>
    <name>F9WG58_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 468</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002235">
        <property type="protein sequence ID" value="CCD16292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12320"/>
    <dbReference type="OMA" id="YYRMYGH"/>
    <dbReference type="OrthoDB" id="559299at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="PTHR22589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carn_acyltransf" evidence="5">
        <location>
            <begin position="19"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="604" mass="65918" checksum="F54E44E7A863AAF6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG80</accession>
    <name>F9WG80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002242">
        <property type="protein sequence ID" value="CCD16314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390299" evidence="1">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="99" mass="11184" checksum="0C80BA5AE02944DB" modified="2011-10-19" version="1">MLLLLTVCAPVCISQCAFLPHTKVTTHVKRIRCQCSLSKCIKFSVDSNEMHSRAPGLSISELLMPLMRHRNGYGAPFKPLLISVKDCTTRQPICVRWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGA8</accession>
    <name>F9WGA8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12810"/>
    <dbReference type="OrthoDB" id="1690975at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="251" mass="28179" checksum="2CDDF7F4B58D3931" modified="2011-10-19" version="1">MPHTTGYRSLLVQHPREINGQLDHVVADFTGVVLRLRVKSTILIGIVLLYRSPLIQKFRECEAHVAAILSALLDSRDIFRSLPRTFVHTLLVALSCEYIGCIVRTLPLSPGWQLVNSFPGILPHTLLVLTSSRPRFHGTHILLTASLLRFSRYGLQFPHLRFCASSLISCLSYKFSQQLAILIDNDFMQFHVHQRFLWVVLHVVVCRILRGSQQIRQISQNTVASSLSLEAATSALDMLPGMSAISEAMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA3</accession>
    <name>F9WHA3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 618</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_15990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002401">
        <property type="protein sequence ID" value="CCD16692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15990"/>
    <dbReference type="OrthoDB" id="1666877at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390332" evidence="3">
        <location>
            <begin position="27"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="434" mass="47284" checksum="E67834EBEF3A2F2A" modified="2011-10-19" version="1">MLKLGVGIGMMVWVMVMVVVAGGTTGGTGTGSNGECKLHDEAAGLLCAMAKLVEKAKNITHNHDYKDVKDAWSNIQYNKDVVDHRVNHLPDIVEEAKNKGTLTEKDAEKLKKAYTEVHEKNKEQHDKAAKSNEAHNNTHRDAKSSISKALGDTLARSNCRSTGSLLDILQCHVKGTESQGANASLSEICKDAKHNEDPGVSQLLTTCLKISKSKTYCNGTGAALKVTMEKWKTADKRKKDTSSGSGSSRETCNVTDEWEKYVLNASTHMSLLDEHVQTIHDANFLTTAYFSVVHQMREDIANGKPMKAIVANARKAGQKGAQVVVEKNDPTSPNASHPTAGEKEEVQVTVQLEGLKSLEDEDHDPAHSKESFPKVYIYLLGLLLPLCCLIVCLTLYGVLRKPRSRSSPSHLDDKGSMPVEAATLGKDGSTRVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR1</accession>
    <name>F9WHR1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002477">
        <property type="protein sequence ID" value="CCD16855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17400"/>
    <dbReference type="OrthoDB" id="939345at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="PTHR22504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28345" checksum="86E8AD31A7E4A03A" modified="2011-10-19" version="1">MEFVPLESFEFLNSLLHSVEAQDCLMTVRLEAFTCRCTRKKKQLAASIADYANKTTPPLRPACPVGLPAPPLLNLSDEGPPTTQFEAVEHVEPSDIDDRLVFLVAALNSIYGEDGYDFSVLTEKDFVTCDEAHVRAEVNTTLRSLPPSCSPAVEQFWARVSEQTSDASQGCEYFRFSSPSCDPMASRALFSQHYFLYNKRTRLLVSLLVSAEGNLYRSDDGCAPDNHLYYDGYSSSSKSPLWPDGPGGASRDGECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI03</accession>
    <name>F9WI03_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002508">
        <property type="protein sequence ID" value="CCD16948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="114" mass="12652" checksum="E7567F86F13575C9" modified="2011-10-19" version="1" fragment="single">MIRSAYFPREAVVSSESLDTLLGETGAMVIGADVNSHHVLWDPLCPSDDKGECIVGWCVQNNRRIVHTRLATRGQPGTAALLSPHITLCRDCEISNWIFALTPDSDHHWIPFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI40</accession>
    <name>F9WI40_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002525">
        <property type="protein sequence ID" value="CCD16985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18540"/>
    <dbReference type="OrthoDB" id="1676182at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="319" mass="35761" checksum="5DF5CA63E4B39777" modified="2011-10-19" version="1" fragment="single">MRRACVKLEHMLHFLPTRLCRGLTVHHLDILYLLPISRGASCRVNDIKELSIRCGPYLASVAECVEQRCIHRGEGIGFDEGMQVLKHMGLVCTTSDWSDSRNDTVGTTSQRVSRTPTITVKLSSVEASSMPRESDNNDNVLLLLHGVVIPYLFSHQLSSRNLPQQRQQQPSPQSEATHCLATTKSSPDQGNGEWLTDEACLALLQPKEVSAAVNNNKKVRQIVSALLSRAVLAGVHDGVLHQPRSGSFCFHHDVIRHPTLRLLALQLWWNRKVEPFVRENVQQHGMLEDVPRGVWMEVAQRRVQDLLVMDAADSPKILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC7</accession>
    <name>F9WIC7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002568">
        <property type="protein sequence ID" value="CCD17074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19270"/>
    <dbReference type="OMA" id="TGQCSQV"/>
    <dbReference type="OrthoDB" id="872177at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="344"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="386"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46112" checksum="5650C88D1A959AF2" modified="2011-10-19" version="1">MRLRSFLLRYYPPGITLEYETSVGEVGEKNIDLLTLTPNTNLELLATDIIKEEPLLSMKLLPQLITYLQRLVDKLRAGYNNNQTFYLFKTLRAHMLPLTNCAFNKGGDSFITGSYDRTCKVWDTATGNEVVSLEGHRNVVYSVSFNNPYGNRVATGSFDKTCKIWDARTGQCYYTLAGHMAEIVCMSFNPQSTHLSSGSMDYTAKVWNLETGQELYTLLGHTAEIVSLNFNTTGDLILTGSFDTTAKLWDVRTGKCVHTLSSHRAEISSTQFNFAGNLCVTGCIDRTSKLWDVGSGQCVSTLRGHTDEILDVAFSASGSHIVTASADATARVYDAATCNCVASLVGHEGEISKVQFNPQGTKIISAANDKTCRLWSVETGQNLQTLTGHNDEIFSCAFNYEGDTILTGSKDNTCGIWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC9</accession>
    <name>F9WIC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002568">
        <property type="protein sequence ID" value="CCD17076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19290"/>
    <dbReference type="OrthoDB" id="1697819at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22114" checksum="AC0512B79381F981" modified="2011-10-19" version="1">MQEHLAQLVEQHPMCRKALRYHWPGPHCHSVRGRQNTEASTSMHQKRPSQLLVPIRDQGCCLTTDANCEQNKQLSMPEGTRNGRMQSQNFHSCSMLSSRQQDVGNNCLHFYGASGTALTQLDAKCRVSANEGKEGECAQQHQSCPITQPHDTAQHAGCYRPKLNVTVHCSGRPTTVIMTGKNQHSDPTCTEWAPPTAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WID5</accession>
    <name>F9WID5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002570">
        <property type="protein sequence ID" value="CCD17082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19350"/>
    <dbReference type="OMA" id="ERCPITA"/>
    <dbReference type="OrthoDB" id="1163845at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="479" mass="52013" checksum="C17E0D560A19C431" modified="2011-10-19" version="1">MQGVNLGDENKLCVQSLEAAEKELLSRCKQLSIIETVQKKTMELLQLCTSIREISFDTEYPFVDLQNFPALGYLVKLFLEEAPWLESFEGICNLPELQAFRVTGAPLRDDYLHTLSAGRNLVELRLESCNDLTDLSPLASIKTLKHLFIVDCVSVKKGIGTLGGLPTLRELYLSGTSMDSESLCGLCDTRSLAVLTIVSCGALEDISLLATIRTLHYLTVEVCTALKTGAGDIGKLPELYELDLSYSSIKDSCLSGLSESHSLRKLVLASCSNLSDVSSLGTMMTLEYLSLNSCGTVGDGAGNIGNLPKLRELDLASTNVTDATLKGLCVSRCLSKLNISACSNLTDLSPLVEISTLEELNIRACMELRRGIGDLGKLPALRKLDAACTPITNDLVQELSVSRSLVILLLDFCVDMTDVSHLANMSTLEELSINSCVSVTQGVGTLRNLPRLRNLNMRAVDASEDELTCLREMGVSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE7</accession>
    <name>F9WIE7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002579">
        <property type="protein sequence ID" value="CCD17094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744692at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="14830" checksum="B7DC89F5AF66D422" modified="2011-10-19" version="1">MRFSISLWASCRFFASVETGVFEKFLRHPQHLSKIIHVICRCIAKRFHFSHNFPVLVFVVCVIRYIRNHALGLLQNSAEQIELVFAGMLVPNSNAQHQRHQRKLHYHSFNLRKKKRIRIFIFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII3</accession>
    <name>F9WII3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 798</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002601">
        <property type="protein sequence ID" value="CCD17131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19780"/>
    <dbReference type="OMA" id="ANRHIVP"/>
    <dbReference type="OrthoDB" id="1127890at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
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            <end position="184"/>
        </location>
    </feature>
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            <begin position="348"/>
            <end position="374"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
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                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
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    </dbReference>
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            <begin position="7"/>
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            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="26109" checksum="EB392A9122F2B493" modified="2011-10-19" version="1">MFSWLLGSSNAQEAPRSGISASSTNKTQRSLEDLELKVEMLGKREDVLGKKMEEELEKAKQFYANKNKQGALQCMKRKKMYEDQLTNIAAQKQNLEVLIFTLQNQTMSMEVLEAQRRAKDELKMANKKMDADRVDQTMDELTEEMEKANAVSEALRQPLDVHVADEDELMAELMDGLGGVQMSQPLKAKETEALDLPKMPSVPSGELPKRQQTADESDEEALRALERELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS5</accession>
    <name>F9WIS5_TRYCI</name>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002630">
        <property type="protein sequence ID" value="CCD17223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="CDYIRLV"/>
    <dbReference type="OrthoDB" id="637376at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="618" mass="66142" checksum="D97CF44D15B84A2E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU4</accession>
    <name>F9WIU4_TRYCI</name>
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        <submittedName>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
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        </lineage>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002642">
        <property type="protein sequence ID" value="CCD17242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02330"/>
    <dbReference type="OMA" id="MGEMTSF"/>
    <dbReference type="OrthoDB" id="938634at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="TPT" evidence="4">
        <location>
            <begin position="31"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="322" mass="35318" checksum="9C80C1F7BF6DC88B" modified="2011-10-19" version="1">MPRHENIGEGLLSRLTLGDNKKICFSLFLNIVSSVSVVIVNKRLVYNEARFHFVTVLTILHFIVSFLGCLGLSMMGYSEIRRLSVIEVLPISAAFCGYVVFNNLSLLANTVSVYQTSKILCTPLIVLIEYVAYNKRESVETLVSIAVTCIGVAVTVYVDTNLTVMGSIWALLAIVSNSFYTIWGNTKQKELGVSAMQLLLYQAPISAMMLSLAIPMDGLGDLLRYEVTFTTLWTITLSCAFAFGVNLSFFLLVGQTSPLTMNVVGYLKTALVFIGGFIFLSSEADAKTLFGVTLTLVGLLFYTRSKMAGVAPVPVQKESRLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIV2</accession>
    <name>F9WIV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="12217" checksum="DB8D2C12121890F4" modified="2011-10-19" version="1">MIPKVSWFKKKNHIISSHSKILFFHMEVTVVTRESTWCKNRSLIKIFLVIQSKKKPKMVTHIPSRPLGTFFINSRFICCRPYLHGRRFVYFQRRGGFLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY7</accession>
    <name>F9WIY7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_21170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002658">
        <property type="protein sequence ID" value="CCD17287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21170"/>
    <dbReference type="OrthoDB" id="1662343at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390407" evidence="5">
        <location>
            <begin position="17"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="30"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="457" mass="49625" checksum="E2DA18AB252EC96F" modified="2011-10-19" version="1">MACLLELLASVAVVIGTLLGDAAVRGAFIQSVDNAEQFALLCRIYNVAKNPPTNHTDLQYHLKIMEEIDAPNASLAEQKRFNEIEKVKNSGSLSEDSNEAIPASWPQRDAGNNAVTTVASGKKHAKVNPAATGEALARIRLRQITQKAHKLIEEIRRLNVTEEIEKAKAEFAKVIFGEEANESDLCHGALKGVSGRAEACGKTGLSSKGDSAGKNLVVDFFCLCAHRADKKNGIDNVCGVQVGGKGDKADKHGWDTAAPLGSSSMWASVKKGCENLLHQHPKSTEEGHEVLKDFLKHLKSGGVYRWGTTNGVNGESSSRKEGMLGTGVGTNEDKEKDLVCNGSKGYGKSGKRPGGLCVYYGPHGWEENIEWLKQLKAALSTVDDMNRKTASVQRALEKLQMLHHRAEEIYEATKVILELENLEGLTAFQNVSGSFTAYNGTRTRSYSHNPHLYFALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ04</accession>
    <name>F9WJ04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002668">
        <property type="protein sequence ID" value="CCD17305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21330"/>
    <dbReference type="OrthoDB" id="1709818at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21331" checksum="44024EB5ED445DAB" modified="2011-10-19" version="1">MSPARQSYFRPIHTSPSISLCPTLTAASQAVAADGRLCDVPRQMMRGSHISLAGLKLTHIIEHSARLPKAFPFTTSGTSSGSHTHTHIRSHQDATCAPMDAATRSHAFASRRHHQLPTHHMPQPPERLIGAHQTHERHNVEPYAQFGATLLISNGAHRAQIPHFHFPLPDKANSPRTNTARHDHEEKQWKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ80</accession>
    <name>F9WJ80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002694">
        <property type="protein sequence ID" value="CCD17384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22070"/>
    <dbReference type="OrthoDB" id="1721091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17115" checksum="A027AFF662A6EB1F" modified="2011-10-19" version="1">MDGGRPSKRAGRNSKFGPPLEVFFAIFPMCVFVYETERGRLYIPRGGRRLCSSGVNAFILSFVKGKKCKSRHREILKSVTEVTPPPLQMGAFRLQAFCKGVCNTFERWGCFAAVADWEIIYTHSSVSAHTLYYRGVWERSARRVLRRVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA7</accession>
    <name>F9WJA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002704">
        <property type="protein sequence ID" value="CCD17411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22320"/>
    <dbReference type="OrthoDB" id="1708582at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="21601" checksum="98013AC66779AEB9" modified="2011-10-19" version="1">MSWYTITSPRTIPWSMEKDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAVSQYLPYLLWKFRLSATPLVKHFGPTETWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVLVEATPAFIQVPYPAVGYLVPIPVTPRPWPGLLNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJC4</accession>
    <name>F9WJC4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002710">
        <property type="protein sequence ID" value="CCD17428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22470"/>
    <dbReference type="OrthoDB" id="1657868at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="612" mass="67995" checksum="7A5962BFF9403084" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY4</accession>
    <name>F9WJY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15870</name>
        <name evidence="2" type="ORF">TCIL3000_0_24480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002398">
        <property type="protein sequence ID" value="CCD16680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002788">
        <property type="protein sequence ID" value="CCD17644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="13398" checksum="3BC5A3D95361A1B1" modified="2011-10-19" version="1">MPFSITPTMLICQLALRLLTLRDRPLHVCFRTLHPYADIFMPIIPVLSSTSTHALCSSCRADVCSSSTLLSSFHLAVSGDGAWNSAPRLSSLYFQSPCGRAVSMTTKVQHLPHISTIPDDAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK05</accession>
    <name>F9WK05_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_02600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02600"/>
    <dbReference type="OMA" id="RYPFREM"/>
    <dbReference type="OrthoDB" id="615868at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="507" mass="57221" checksum="124DA40A8DBA5029" modified="2011-10-19" version="1">MYSSPLHLHSEKKDGTIIWKPAKVMTTMQVTSGEGSRRADGQTMESEVNTATVLRYPFQHLELGWLMEYIETCLPEEERRPAATRLLNDFMAFAVLHGDPFLEKASCEFYKYVNKGSENRPRLSKDLSSQWGVVYAIFEAIQKASKYPQSDMNVRAHILEHIEKTMKDVGIVVSTQPRSGTSKAAEVITSVAAHVQRMRGAPESQEIYSSMMRLLRMLFFCFSPCIGVYSIFQDAISNGKGTFVCCEGCPCYNKLRNAYTLFIRDVEKMKVVDCLLMMAVKEEDAIACRLMRDLFTRLDYRNPFLDKPVRRIQNGSLFAARVTLFDALHNVKELLSDTRASPSRLTPHVESILLALYVVRREIKSIRDSSEQIEIVDQAIAAADAVYVRLGTDKVVQHLRTLKDHIFTIFAFLSDPEFHLAVHSRDLSNPRGQGGTKCCNPACPGNARETLKCSGCRMTSYCGVACQRADYKSHRPLCTEMGRRKATPNVVKVVETEIRVLKPIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK48</accession>
    <name>F9WK48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1774</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24950</name>
        <name evidence="1" type="ORF">TCIL3000_0_43540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001213">
        <property type="protein sequence ID" value="CCD13616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002808">
        <property type="protein sequence ID" value="CCD17709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43540"/>
    <dbReference type="OrthoDB" id="1731564at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16385" checksum="E921835BBA744EA4" modified="2011-10-19" version="1">MRSVCNKWAALALSHRAHGRPSLLSSLPHYTTGGSICCRDVQPKSAGITHLSLLPTLHTPFSAASSVQLLTGISQEAVAWPCGSSFKQIAFRVVKVRRLLPTVVQHGSPPGTHAKQLHSLRKSKSSEVQAALRQYGPFDIAVPASSVSCDHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W377</accession>
    <name>F9W377_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000368">
        <property type="protein sequence ID" value="CCD11585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1248045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16120" checksum="FE2C1BEE637F2BA8" modified="2011-10-19" version="1">MNFLRQKLFMRDTPAALSTSGKPLPLNYKLSTFRWHLDSRPPSKAILVHDLFSSSASWQTLLHGSIGKMPGRGLTPRVPLELYAVELRGHNYSMSVPFPEEGSPFALTCASDVLLLQQQIIRTDAKFIGIGFWCACCLPRCASVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3E9</accession>
    <name>F9W3E9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1045</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000401">
        <property type="protein sequence ID" value="CCD11661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26250"/>
    <dbReference type="OrthoDB" id="1761689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="26210" checksum="26409F5625A9E4E1" modified="2011-10-19" version="1" fragment="single">MIPSFSFMHRYDNGLHRVSLSRPSSAICCYISFHISAFPFSRCRCHREPLYSGGGSLASPRVRHRRSHPTTESVATPAAGAPLGAPAPAPAPALVPRPAPQPPPRGHCPRPAARHPPQVPPQLRLRLRLPLPASPRLLESPAPQPALRHPRPSAPPRLLQLQLSLLLLPPRPLPLPLPLLPLLLLLRLLPLPTQCPPPLQPHIRVVDHPPRHIPQQWKDPNLCEHRCLIRALQLPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G0</accession>
    <name>F9W3G0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1049</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000406">
        <property type="protein sequence ID" value="CCD11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26360"/>
    <dbReference type="OrthoDB" id="1746704at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16582" checksum="17DC996D560195A6" modified="2011-10-19" version="1">MNSSKRPAELAAKAEALDASFSSLSTSFLVLSHSFLTCRNRRPVILHASEPIPLDLDWMNLDCHSSSFISRCVIFAAPSYTCCVAQGVTSFKVLLKVHMAAPALVGMALGVFPVLSTGDHARKTPTSYNHFKRSSIATDLYLIFSVCLPILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3R0</accession>
    <name>F9W3R0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1094</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000456">
        <property type="protein sequence ID" value="CCD11783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27280"/>
    <dbReference type="OMA" id="YIFTYIH"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="626"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="691"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="868" mass="101759" checksum="984587FD61A40E8C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U0</accession>
    <name>F9W3U0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000473">
        <property type="protein sequence ID" value="CCD11814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27580"/>
    <dbReference type="OMA" id="WGPGDTQ"/>
    <dbReference type="OrthoDB" id="930591at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45410" checksum="707E9848CBECC527" modified="2011-10-19" version="1">MKEFNPILSPAQRKASMHTYPPVPKSCVVTGGTGFVGSRLVEMLVERGAERVVCFDIVPPQFTVGAWQHPAVEYVVGDIAKYGDVLRAISGADCVWHLAAAVGPFHPRELYRKVNYEGTVNVIRACKQLGVKKLVMSSSPSTRFKGSLFHCPCVDGLTEDEMPKLPLCSYMQMYAETKAAAEMAVADACCENLLTVSVAPHQVYGPRDNLFLPNMLEAAGTGKLRIFGSGKNRICFTHVDNYAHGLIIAERQLYEGSPVLGKFYIVTDGHTHPEPDAYCIFWDELDKAVKAMGFTSIHNKVRLNFWFLYIAALSAELLGWVLGCSFKLNVFNVFVLTMHRWFRITAAERDLLYKPIIPFRDGWDDTIDWFKERWLPTFERQNRSLLGLSHCSQQKIDMQAKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X2</accession>
    <name>F9W3X2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000489">
        <property type="protein sequence ID" value="CCD11850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27900"/>
    <dbReference type="OrthoDB" id="1704469at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="23071" checksum="BBBA0F8E24C9FEA0" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGESPMSSARARRLFANWKACLRAAGGGQAGRHGEGSRGFRDQTGDTHNRARECQTCHGKGRKFMFQLRRSCCVRLNGVCAQAKNSLIHSICGVPVVEIAVAKDTPSALRNVSCGGGGGLGHPRSSKGRGPNARGLFACRVCKWLLKACASRERHRIGRRGAQAPRLRGLMSRNANPRAINAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y4</accession>
    <name>F9W3Y4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000492">
        <property type="protein sequence ID" value="CCD11862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28020"/>
    <dbReference type="OrthoDB" id="1690676at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28577" checksum="4AD55F75186EE137" modified="2011-10-19" version="1">MHCGETLLPFTLHWAMPTLECVVHREGDPHRLVFHLSCGMRACASQAGATVLVCAAASCTRKASSFLRFHVPAYSSTFPRSLPIHLHLCLLHTLPASVFYSFYSFSLYGEVGTTALATATLRGLDVSLTCDESTIRNGTLCHLRGTCLLVSGWLLQFSRVILTPIGLLYALVSDGLYYALHMLTLWAVYCFLILVNFILTRIRSLVNDVVLFWLSLLSVCFASTCLFSLPYDECFLQHQRYFSLTMSAFSPSPYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W410</accession>
    <name>F9W410_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000501">
        <property type="protein sequence ID" value="CCD11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28310"/>
    <dbReference type="OrthoDB" id="1722763at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394543" evidence="1">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16666" checksum="987FB394A52AA4E3" modified="2011-10-19" version="1">MNAQTQKPLLLLYCLISSVMGYDVDLASLCAVKHRTAITLGTMIEHYVAAGKSAWRDFMLAASLWSQRSCLLSLRGHVFSVDRPSVVEIVTGAYDPRKKCNRYSAHCACLHFQTAQGPLVYRTHVVGSLCYAIHACYSVQALMPSALNQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W444</accession>
    <name>F9W444_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28650"/>
    <dbReference type="OrthoDB" id="1701523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="21713" checksum="F74D50008BBF1A69" modified="2011-10-19" version="1">MRWGLHYRGASHSRTLWSGVKTALEFWKERCVPQRIQWKTDLPRELQRNWECLGVAWKERRFGAAERIISSMTYVALLWAFLKGFREQGALHHMAQETPDVALRGALGTPYPNGKRSWKIWVNEAMGTREETTNWGSAVEACISCFPWLRLRGCNNMVVEAPIEKNAFRIFRQDITGRVSFVFNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W465</accession>
    <name>F9W465_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_28870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000520">
        <property type="protein sequence ID" value="CCD11953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28870"/>
    <dbReference type="OMA" id="HWFLETS"/>
    <dbReference type="OrthoDB" id="419481at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="SSF52087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="96"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="543" mass="59684" checksum="CFA1BA5D5016A15E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4I0</accession>
    <name>F9W4I0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_29930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000559">
        <property type="protein sequence ID" value="CCD12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29930"/>
    <dbReference type="OMA" id="IKKRAYG"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="96"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="332" mass="36525" checksum="B72A3B6FEB2EA22D" modified="2011-10-19" version="1">MEDCVVNYGAVRIALWSVARVFDPSLPCVAEAVTPSIIYEKRGFLGLTDGQLTGVLNGALFILVLAIAGLALMLSKIFQDARDNRRAPKEPTDPVTLIFTDIESSTALWAAHPTLMPDAVEAHHQLIRSLIVRYGCYEVKTVGDSFMIACRSPLAAVQLAGDLQRCFLHHDWGTTALDDSYHEFELQKAEAGGYVPPTAHLDPCVYRELWNGLRVRIGIHTGLCDIRLDEVTKGYDYYGCTSNIAARTEHVANGGQVLLTRAAYYSLSTAEREQVSVTSLGEATLRDVPDPVEIYQLEAVPGREFAALRLEHELDEGEQDISSSATDSIRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K5</accession>
    <name>F9W4K5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000568">
        <property type="protein sequence ID" value="CCD12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30140"/>
    <dbReference type="OMA" id="HEDYDMS"/>
    <dbReference type="OrthoDB" id="1455711at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029302">
        <property type="entry name" value="IFT43"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15305">
        <property type="entry name" value="IFT43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="25651" checksum="EB8B60DDE5D4A787" modified="2011-10-19" version="1">MPPKYGRRANASGHKNASGGTTHQPSGGGDAVQNQQAPKDNVVAASNLRKLDDGVDEESRNLSDMKQKAEAKRLVELVAEAPVGYTAALPRLASLDVSNIWNDFLQAIHEDYDMSALTACLSQQLDDEDAPWNPDMLLVQLTSDMLDAAQYNDGNGANSAAAGGRNDGLNDGASMAAAGEARRRRKQLLESANEAQEESAGRRRRQENPKVKEETVAPKAPRAFATGDNSRGVTPRGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K6</accession>
    <name>F9W4K6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000568">
        <property type="protein sequence ID" value="CCD12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30150"/>
    <dbReference type="OrthoDB" id="572856at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004127">
        <property type="term" value="F:cytidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026867">
        <property type="entry name" value="AK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359:SF105">
        <property type="entry name" value="PTHR23359:SF105"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="387"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="706" mass="81430" checksum="CDC3AAF6A11DB682" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P8</accession>
    <name>F9W4P8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_30560</name>
        <name evidence="10" type="ORF">TCIL3000_3_3520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="HE575316">
        <property type="protein sequence ID" value="CCC89917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000589">
        <property type="protein sequence ID" value="CCD12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_3_3520"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="817008at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC89917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="389" mass="44450" checksum="9FCC5D11E03AC8F1" modified="2011-10-19" version="1">MTEPVVTPWCVEGDVNYDKLIKDFGSHSIDSALLERIERVLGKKPHHFLRRGIFFSHRDLNLLLDVYEAGKPFYLYTGRGPSSESMHMGHLIPFMFTKWLQESFKVPLVIQMTDDEKFFFRNIPMEQVENMTTENIKDIIAMGFDPELTFIFRDFDYMGQMYRTVAKIERAFTASQVRGCFGFAMEDNCGRWMFPAIQAAPSFSSSFPHIFPPSMGNVFCLIPQAIDQDPYFRLTRDIAPRLGYLKPAVIHSKFFPGLTGSKGKMSSSSGAAVLLTDTEKMIKDKINKHAFSGGGATKEEHLLLGGNADVDVPFQWLTFFLEDDEELARIRKEYMLGRMMTGEVKKILINILSNINKCHQERKKKVTDEDVKLFTGIRPMGPAKEKMEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P9</accession>
    <name>F9W4P9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein TCIL3000_3_3510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_30570</name>
        <name evidence="5" type="ORF">TCIL3000_3_3510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575316">
        <property type="protein sequence ID" value="CCC89916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000589">
        <property type="protein sequence ID" value="CCD12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_3_3510"/>
    <dbReference type="OMA" id="KRITHDA"/>
    <dbReference type="OrthoDB" id="1204812at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="PTHR19957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="164"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC89916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="29262" checksum="C987018B7750A4BD" modified="2011-10-19" version="1">MDDPSWNRNCDLLAKALQSLDSSTSKIRRSTNKLLTLRDIATEREKVKRVTSSTNAKEVHAVQDALGFLERYMRLHPAQLRGQGMKLTAEAQVALDNYKKSCDAFYKRCMALEESLRSGKKTTRVKVEGGDGSDDDDLDEGTSLLRGGVADYKQKQEFEDDLYNEIMAERMRETKEIADSVRDINDIFNHIHSMVEEQGVGLDAIENNVTRSSQATRSALSHLQHARENQRSSRCNRMLMIFVVVLILMLLAMLWFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Q6</accession>
    <name>F9W4Q6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000592">
        <property type="protein sequence ID" value="CCD12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30640"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20149" checksum="E27574CA52C2F1A0" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQENTPWSMEKDVVEVLLKGIGDPEKINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4T4</accession>
    <name>F9W4T4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1227</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000604">
        <property type="protein sequence ID" value="CCD12179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30880"/>
    <dbReference type="OrthoDB" id="332184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="45701" checksum="41B86612A4E8FDD8" modified="2011-10-19" version="1">MVLEEEARAELDIMMNPTRWIKFASLPEVNERTRRQRLIAAELKQRMHIYTNIRYFIADAAQSDIDSLFSDEKTARLVLTADEMKSRIDLYSWSQAPGNAYTPRTAAIAAAGVGGLPPQALHALLAEESVERVHLGNDELRRRNLYQREYIVTTEDAARNEIELDELDEHVTMLDSLVQRNRALLERRRQEQQHSVKLLSEEQYYRKSIINDEQDEFEDLMEHIDAALNDILMAGASRLCVLQDFDSPSRRRHVPATPRQTKPFHYMSFAPEDMDHIPTANLAIEGMLGCSINKNLEVTCIARPLPKAEAEELQFQAGDMILDVAGYSLHSLSHLREVLANRAMQIQHEAREEFDDVPEEELLTNPALQKYVEVLCEHHNFLVQVLRGCDIFQIIVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G1</accession>
    <name>F9W5G1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32930"/>
    <dbReference type="OMA" id="VACHIDK"/>
    <dbReference type="OrthoDB" id="1327889at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48415" checksum="8828CA6588294062" modified="2011-10-19" version="1">MEELQRLAASCKAELVGRTQHWMAKLDGAFSNGATMSLQALRSAGVALFTFCLASVAAFVVLSACVAASVFGSLLLRQYILLLVPGNELTTLDFNTMPLETERWRLHDLSQMIAQFDVTPSDSLHGASTILTNRGAERDERHTSALRTEGDTLKMSLISKMVYGTVATSTLILPSPVRGDVFHADGSVSTEALFSQRKPMFHAKGVYNAKMQLVFHKEDVGRDISLVLESVVLMANESYVPQPLKSLRELLRVTSSFTITTGRRFGSWPRELLAESLHAAFCFPIWIFQTLSDVLHSDVFPVIDRATEVAVVTSVYTNFEPPLHLQPRLRAINFTLYHSEGDTSSKPRLKRALFHTSVELKGLAYYFSTYTISSFIGVTIFLLTLLGTGALTFAVAAGLFVVLPRLRHTAKCGGQKPLGRVSPAASHDGRVMAPKEEVDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5N2</accession>
    <name>F9W5N2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_33600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000741">
        <property type="protein sequence ID" value="CCD12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33600"/>
    <dbReference type="OMA" id="ASHGIND"/>
    <dbReference type="OrthoDB" id="116501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043547">
        <property type="term" value="P:positive regulation of GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="PTHR21422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GTPase_cat" evidence="5">
        <location>
            <begin position="618"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="738" mass="82715" checksum="CF2C903D94F077BE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5N4</accession>
    <name>F9W5N4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000742">
        <property type="protein sequence ID" value="CCD12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33620"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389822" evidence="2">
        <location>
            <begin position="28"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43933" checksum="D37A8285B5960985" modified="2011-10-19" version="1">MMEPRRVGKGVLAVVLLMAMAVGRVWASYTDYKEGHNFNGEDHDVLCAVFQASLDLWEASRDSELKLDAGLLGGVRQAIFGNYGSTNIEDFKDTLPKDYSKPKHRGVWCGTCHYQEKYYPGRSITHDLMCLCTPGYFGEPFYYYYWIFGYRFGKTGFKLCGKEHADMVKDQFDGWYAYQGEEAKGLEKPWKTVVMGCFNEWKSNKGTGKPNLEEKVATLNETIKKFISVLKDSNGRHKLGGMHGHNTDSDGKDEKSMHVWYGKCDDKKRPWWKKLSDVLTKKTLAQLVVKPHPTEPHGGPSSGSSGRGTTQQGHPGFPESGSKFQDEEAGEGSPEQGSNSTQTQGLTNGTATLFDGTGSGSMGAEGNYSAHFQYLRSGTHITLSYSWLLSALLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E1</accession>
    <name>F9W6E1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000852">
        <property type="protein sequence ID" value="CCD12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36000"/>
    <dbReference type="OMA" id="HAWRYTL"/>
    <dbReference type="OrthoDB" id="821308at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="2">
        <location>
            <begin position="298"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="768" mass="85181" checksum="16D9EED862207917" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6G6</accession>
    <name>F9W6G6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1463</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000866">
        <property type="protein sequence ID" value="CCD12771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36240"/>
    <dbReference type="OMA" id="PRPFHEQ"/>
    <dbReference type="OrthoDB" id="1243287at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="322"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="418" mass="46716" checksum="1DCB9B10CC1D497D" modified="2011-10-19" version="1">MLGRERKAKEKRLQQARRKEELNKIYTQLQAVIQAGRAGTSEVGGTDDNSDVSVLDEGRNNIVLTNVSDLGKTQSSDPPKKGKGYSSRDRTLPAIFAEQRQTSYKVDLLCTELKGAISKMEFEYVRRRRALRAGALDDLRSHAGTNARPAPSAAKLQKYRERCTTSEDGEVAIDCTVNDSGGDAPRGRCSADVHRVRIAAADEGLRDDQSVADYAAEPDVPLYCAGRTLRSEIEVMDDSIKKVSHCVASMSQLEEMDSGTPWWESAMLVREMKALSIRGNYHVRNILRWSLCAQDHFLMDVVSKNAQSARCSEEMVYMREQVGLFEKRNEQSKKVLAEAEAEIDALKESLMKASQVKSGMLEKVLELAQETGRVPQSCTSVQCAEMVMLLEHAKFPVILHADVERVKAWLQRRTVLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H8</accession>
    <name>F9W6H8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_36350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000873">
        <property type="protein sequence ID" value="CCD12783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36350"/>
    <dbReference type="OMA" id="WREIRCY"/>
    <dbReference type="OrthoDB" id="1185596at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="PTHR10676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MT" evidence="4">
        <location>
            <begin position="192"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="763"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="542"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="907" mass="99575" checksum="A1388BD3EF0B0793" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6L5</accession>
    <name>F9W6L5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_03650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000894">
        <property type="protein sequence ID" value="CCD12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03650"/>
    <dbReference type="OrthoDB" id="1674775at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388732" evidence="5">
        <location>
            <begin position="20"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="357" mass="40031" checksum="E749424EB24AA8AA" modified="2011-10-19" version="1">MMTMKLWMVVMVMVVGVGAFEGNRDYNVKEYEALCAVLKAAVSAFQSNRGSEGLKQALHRTIFGNKTGGNLQTLRSTFPTDYEGHEIHDTPRSLWCGDPPEGGYNEESQVRTSGHSAPHGLLCLCTTGKGGWPLSRDPGTTLCGKDKSALGGASEGWVRLTDWSDDVKGKEQREATWDNVTRPCLHEDGRKGENLNDAFKKFKVALVRKLDDDSENKYTETMGPKFANMYINRYQLGNGNPSKERACDGTPELGICLLYYDNMYPLPWWKDLEDALNEEEREKRRQEEIRKQESQSKQQPHSSELPHAEPLKSSLTTTHDTKQKNQESDTAQFSIINMKSGTSITTPLRLLSAAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W717</accession>
    <name>F9W717_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_37940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000963">
        <property type="protein sequence ID" value="CCD12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37940"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388747" evidence="6">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="47"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38330" checksum="E83F6AADBE52F27F" modified="2011-10-19" version="1">MWGNVMVVFVFSHYLVEAVHCHNEPEQKLLCNIFRQSERVLQKFVDTELLKEAIYGPTKGNALISKDGNLTLSSSCHTPVLRNEYCKYSRSERAKDGCFAESLLGTFFCICAPGAQRVNVNNLCGVDITRNFYLWHGPFPPNEGDIEELFDSVWKDVISNCTGESESVGSGNEELEKLRKAVEDVENTIKQDRNSFYYYLGGSGEKDCSGSDGKNVCAAYRKKDGIVSKAHIPWVKKIKEAITQLQKVERERQDLDFMERTTRKQSESIAAPAHHAGKGNAELTDQREGIVTPPNSSRTLPKTEISTKTSPITNIPHLATYLNEDGSLLTNQKWLVIAAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W730</accession>
    <name>F9W730_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1555</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000969">
        <property type="protein sequence ID" value="CCD12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38070"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23323" checksum="BAE3B9DE166E9B23" modified="2011-10-19" version="1">MKWTFTCPAEVEVELAVVELVRASLEPLETARGFFRSLLHGARQYDAEDGRTLTTDTLQKAMRQVVFEDEGGGDLQTLAMRRWTTTLRYALDPETAMHEFLLAFLGELHTLDRQVGNHRGADAFYKAAGRIVFGEARPSERDLQTLAIQYVARSVLQSEDPEKKARELLGGVLHEARHRDGEPHHHQGEEALLKAMEEILQKTSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W767</accession>
    <name>F9W767_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_38480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38480"/>
    <dbReference type="OrthoDB" id="131230at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="PTHR11932"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="SSF75632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULLIN_2" evidence="3">
        <location>
            <begin position="542"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="947" mass="106884" checksum="EC792D2A198A422D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W772</accession>
    <name>F9W772_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000993">
        <property type="protein sequence ID" value="CCD13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38530"/>
    <dbReference type="OMA" id="EAWIGTC"/>
    <dbReference type="OrthoDB" id="1459514at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="595" mass="65113" checksum="BD6F33BF5BEFC3A5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7H5</accession>
    <name>F9W7H5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1612</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001034">
        <property type="protein sequence ID" value="CCD13141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39200"/>
    <dbReference type="OMA" id="RQVKHAP"/>
    <dbReference type="OrthoDB" id="1095804at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PTHR21207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="312" mass="35303" checksum="E173D662463DB035" modified="2011-10-19" version="1">MAFSRRERKQLLRDRDLIPQMAESPFGPFPPGYGIKNDITVMKKGCPVQESQKKKKPGVENQKHEKELTECSAHSQQILVGHTGTGGMAVSTFKNSGSSFSLRVGCFGDIKGPEKAGALRKQVIPPTEFRKFYVRGDLPITIQQGASRSLSWRLNVTLLDYHHFLPIFFDGLRELEEPFKFVALQGCYDLLEKGGEKILPTIPQLIVPIKTALNTRHPTVIINVLKVLQKLVESADFVGQALVPYYRQILPAFNLYKNRNKNIGDRIDYSQTKRQNISDLINETLNLLELYGGEDAYINIKYMIPTYESCVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K7</accession>
    <name>F9W7K7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1624</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001047">
        <property type="protein sequence ID" value="CCD13175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39490"/>
    <dbReference type="OMA" id="NKNPFGG"/>
    <dbReference type="OrthoDB" id="1811759at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="21528" checksum="1352D5F7D8EA0BF5" modified="2011-10-19" version="1" fragment="single">MNTGFGGGIGQQPAPGVFGQQSVGAFGQGGVTGGFGQPAATGSFGQAATAGGFGQQPATGFGQAGATTPFGQATGRGATGGFGQPTAGAGLGQTPATTGAFGQPAATGGFGQAATAGGFGQPAATAGGFGQQSATGFGQAGATTPFGQATGRGTTGGFGQPTAGGFGQPAAGTGLGQTATATGAFGQPAATGGFGQQPATAGGFGQQPVTSFGQTATAGGFGQPATGVFGPPAASGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7T8</accession>
    <name>F9W7T8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001079">
        <property type="protein sequence ID" value="CCD13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40290"/>
    <dbReference type="OrthoDB" id="1700047at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="24489" checksum="58ABE4F632CA5C43" modified="2011-10-19" version="1">MTPPTLFPFCHPFPIPISPFSETSIKIPMSFYTITSPRTIPWSMEKDVVEVLLDGVAYADKINLYWFLRPVLACLPVDLVIFTLRDFVRNPRHCIPAANVCDALWQYLPYILWKFRQSATPLVKHFGPTQTWTKWHWDPWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPYQEVVVVEAAPAFIQVPYPTVGYLVHLPVTPRAWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y3</accession>
    <name>F9W7Y3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001104">
        <property type="protein sequence ID" value="CCD13305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40720"/>
    <dbReference type="OMA" id="LVEFGRC"/>
    <dbReference type="OrthoDB" id="361640at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1071" mass="120295" checksum="AE0997242C926AB8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y5</accession>
    <name>F9W7Y5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001104">
        <property type="protein sequence ID" value="CCD13307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40740"/>
    <dbReference type="OMA" id="DLTECET"/>
    <dbReference type="OrthoDB" id="647873at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="456" mass="49604" checksum="245FA12C462E2857" modified="2011-10-19" version="1">MNSSARKGTTATALMSTKNFLELIPLDVDLETTRQLVLKGKNITAIPPNIGVLLREVRRLDLTENDIRDVAPLATLTNLTSVNLTKNQRLLSVAALAPLQLTVCVLAHCGLRSLAGLEGSAATLRTLIVNDNNLVLQSPHGCSVDGVEVEDLGIAVKNYEVIACLTGCETLVLSRNPLLCSLCVPPAAEGEGREGREEKPEAGSGPEREQDWTHPLSAITKMSSLKKLSLSDCGLTHLPRRWFVPMVTELRLSRNKLTTLVPEGVLFRSVKILDVSHNELEEASTLRRCRFVRHLSVCGNPFMESGKVSIGLKRKAGEGDGNLQDGEDDVPPTPARARGAVLRYLMRVMPHLEVLDSTPLARFMEGVTNEEQLEEEGKSVHTAKAKGQSGADVAGQQAVVEDEDHVLDPPDVSEPAKAPIVRREHTNLLATKKKKYAQGADVAEIMIKRKSEVSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W825</accession>
    <name>F9W825_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001123">
        <property type="protein sequence ID" value="CCD13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="114" mass="13099" checksum="F4B36E528AFC2F58" modified="2011-10-19" version="1">MRKYYNFFKSCVMPQHQISLISISLKQYHKQCHKSNKLSNIILPSCYLRIEFLLAASFQTDKILNAGGIIYIYRTLDSPNIETKELSNTVVANRARLCNFSGENTKEKGNDFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8E9</accession>
    <name>F9W8E9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001165">
        <property type="protein sequence ID" value="CCD13481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42300"/>
    <dbReference type="OMA" id="ACKKQFK"/>
    <dbReference type="OrthoDB" id="858842at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="42972" checksum="7ED48EE51E9E3D3A" modified="2011-10-19" version="1">MSKAPRRCHYDVLQVARKATPEEIRSAYKKLSLLFHPDKNYDNQESAAEMFKDIQNAYAVLSDPDERSWYDAHRESLLNGCETCSSEYDINLYDYFTARCFEGFDDNEGGFYDVYGKVFARIVETESEHNAGAKLWPSFGDSATCWEDVSKFYTHWNNFSSYKSFAWKDEYKVNEIPDRASRRAAERFNQKLRLAAKREYVQVVRHLSNFVYRRDPRVAKEAKLKEEEKHMKDKEREEKELERARNRRLANKKLWAEAAKREADEEAARAERGESLDDCTLDLLYEMQQRQEQSIKMKDENMREFAMLSGDYDDSQSQKWSCPACKKQFKTEALYKEHNGSSKHKAKLRQLRAKNVDTEALMKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8G7</accession>
    <name>F9W8G7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_42450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42450"/>
    <dbReference type="OMA" id="ENHHLAC"/>
    <dbReference type="OrthoDB" id="904682at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="356"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="431"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>a nucleoside 3',5'-cyclic phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="638"/>
        </location>
        <ligand>
            <name>a nucleoside 3',5'-cyclic phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="680" mass="76719" checksum="C5AC545D87D2AAE1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8J5</accession>
    <name>F9W8J5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1737</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001172">
        <property type="protein sequence ID" value="CCD13527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42730"/>
    <dbReference type="OrthoDB" id="101142at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="SSF81837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH" evidence="1">
        <location>
            <begin position="341"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="993" mass="111028" checksum="6F4410AAB2DC878A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I5</accession>
    <name>F9W9I5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_45760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001317">
        <property type="protein sequence ID" value="CCD13887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45760"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390035" evidence="4">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="100"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26923" checksum="E39FCC9D2EAFF15C" modified="2011-10-19" version="1">MWNNVFFLTIILHILCFSTRSETYDNDTERKLLCKIFISATNVMKKYEENKILKETIYGTRGRALFNERGTVELPWSCGLSGTGRGSLYDYYHGGGCFADSLVGTFMCLCTHGGNSDSKNFCRLGNVGGVEIWSGWETKESTKDLFEKVWKKVRESCFKESRSSPGGEDDLRNLREVMKNVREQLRQGNEYFYLGGKEERSGCSGVNGDDVCVRCTGVSKDNAIIPWMKKIDGALEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I7</accession>
    <name>F9W9I7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1869</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001318">
        <property type="protein sequence ID" value="CCD13889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1709794at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20369" checksum="212DC91D4DFFF390" modified="2011-10-19" version="1" fragment="single">MFLCLYMNYTTFSMIDRSVSMRIKSLSPYREHKTGYKLYKTMKRTVDRLHAMGIISLHQWASAASVGEVESVDAHMKGELNAALLSARRNEETMRVGNALGGKEVDGVHDSVFNARWSYVMMSDEYSKKWLGMGVLLVSEGEQPHLWSEAQADVPYDPEEPWEGDEVPGVSGKLVMATLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA72</accession>
    <name>F9WA72_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1943</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_47880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001401">
        <property type="protein sequence ID" value="CCD14128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47880"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394632" evidence="4">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="50"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20103" checksum="B73B1C42E949ACA5" modified="2011-10-19" version="1">MLPTMRVRLVVMVSCVALVGGNKEHYNKEEHILLCEVLGAAVKRWGKNGENVTDQKVREALMQTIYGENEQKENPSKLNFPEEYGSSVDENSHNHRFEWCGTCAGKHYPGESATHDLPCLCTLGPDGIPNKTDDTLCGKKANELRAQQQERMRFGPNSQALKNTWEIIVKSCPKTGGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG7</accession>
    <name>F9WAG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001433">
        <property type="protein sequence ID" value="CCD14229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48740"/>
    <dbReference type="OrthoDB" id="1702045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="22875" checksum="992E2FFA442C226F" modified="2011-10-19" version="1">MIATLGNGSERCSGKGLQHSCRILRVAEWESPGESPMSSARARRLFANWEACLRAAGGGQAGRHGEGSRGFRDQTGDTHNRARECGTCHGKGRKFMFQLRSCCVRLNGVCVQAKNSLIHFICGVPVVEIAVAKDTPSALRNVSCGDGGGLGHPRSSKGRGPNARGLFACRVCKRLLKACASRERHRIGRRGAQAPRLRGLMSRNANPRAINAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAQ4</accession>
    <name>F9WAQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_49580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001469">
        <property type="protein sequence ID" value="CCD14325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49580"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="117"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="436" mass="49357" checksum="25F5FDDC5302E818" modified="2011-10-19" version="1">MPHEMSSTPTGLGCKFCSFHALILDALEMLHGSLLVTGFLAHIALLATSDMENEHEKLIFCLIRLMAEREPKELVFRNSVEESEIVSRIKQLNSSVMNFHRMKVGGSERRYVDKRSKEYGREIHKILEAALHLKAEADAYKFQAAAKRDSARANLKRVIYGDAMNFTAEDTDVQRRIDDNTSKENVFQDIRDKGKSCNGPGAGRSLINDYFCLCFTESHLGDNEKSYRGVCGDGIVETTWDDTKEGWLAKWHKNKDKGCERFQGRLPSPPLIEEALYLFNKTVDVSHTKYHEKGVFGHHQPHDVDGKPISCDGTGDKKTCVDYNHVLSHGGIPWVNRLQNASEDLREMEDLVSKSESILTRLELLEQDAEQIYVEAKFSLHLPEKNDLDSLMEEENALDDTEPNSSLDDTGASYSGRRNFDTIGMILMTLPLLSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC22</accession>
    <name>F9WC22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001657">
        <property type="protein sequence ID" value="CCD14809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="65609at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="17579" checksum="54756BB8633219CF" modified="2011-10-19" version="1">MGYMHRFTPWEWIAVQEADQPLIAEQIRQDNVGTSYFFSLNRYWRYKASPHGYIRHFENEVRDLVQFVDGVTPWKQAQKIRTYWEVRAHHPMPQFNRPEVAMHRNTMGLLPSHTWETDKKTGKVKAVKDSVRDYQTKTPYPKWVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC31</accession>
    <name>F9WC31_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_54000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001661">
        <property type="protein sequence ID" value="CCD14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54000"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394858" evidence="4">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="81"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="48949" checksum="CC3B3E40E8A142B3" modified="2011-10-19" version="1">MVIVKLSLVALVFCAGAALSGKKPPSAKEFNLFCRILRVANDMMVEPDYVYDENTDRETLKEMEVLYNATTDNMNDFRRTLWDMKDFLKEHPPPIRLENRRKAHSEIKKLIIKAEREITENREIAVEVNKEKDAAKWLVLQGMYGDNVKDVPREEGAWTDMRNNSENIFVSNTSAAESCGNNSAAGKTIFNDFFCVCVGEGVEDTEGPCHPGIMAPKRALKSNKHCYEDANSDNCTKWTEMKHHSSSIPPIPLVQAIGKIEQQCRIEIGKEEKVKDIPNLLKEFIELIGVGEAKDGTNAKNIFGHSGRLEKNGNNNVNQCTGAGITGDKDQPDYHNDRICVDYTKNLKEGKTYEIPWHNKLKEAFDKMQEAKKIEDKIFQNHADILLLKTKAWTAYSIEKDDETINLDDMNISSIFEGAQLPPLFPFIFLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC38</accession>
    <name>F9WC38_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001663">
        <property type="protein sequence ID" value="CCD14830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54080"/>
    <dbReference type="OrthoDB" id="1706053at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19813" checksum="DDC53E19E05F4BC7" modified="2011-10-19" version="1" fragment="single">MENWKPRRMGNGIMVMVMSMPVVKEWVWGSVEDHNEGYSFNGSEPDALCAVFQASADLWNASRNSDRRLTKGVEKYLGQALFGNTGSRKLETTTDALPKDYNNHKISRCGVLCGTYKYREQAHYPGQYTPMTSCVSARRGNRGEPFYGYWFFELIFEDTGFQALWKKKSGYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC65</accession>
    <name>F9WC65_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TCIL3000_0_54340</name>
        <name evidence="15" type="ORF">TCIL3000_11_4310</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL3000</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion inner membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001675">
        <property type="protein sequence ID" value="CCD14857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.4310"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54340"/>
    <dbReference type="OMA" id="HINNIYA"/>
    <dbReference type="OrthoDB" id="1575881at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="PTHR13462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="MCU" evidence="14">
        <location>
            <begin position="126"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCC95026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD14857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="249" mass="28383" checksum="5544F8A37369AA21" modified="2011-10-19" version="1">MRRVVSTLAGRCKGPATRHFPAGYYPLAHLQQRVCCSTAKGGEERNISKDDDGNCLSFIPQSQLTRTSLPLYHSRATSEAPSSLNVAVIADVDAFNRLVESVFTSNEKGVNSVIRDLKDAWRYQIEAIAPKVVAKHRIDDHINNIYAPLLRYMIAVLLVGQFIVFFHWVFVVFDWNLVEPITYFIGYTTVWISLVLHCYSPRGLSLEAVLAERRRGVLYKRAHIDGKRVERHLKHLSDVESQLRRYGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCH2</accession>
    <name>F9WCH2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001724">
        <property type="protein sequence ID" value="CCD14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55330"/>
    <dbReference type="OMA" id="NPDEWHE"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="588" mass="66985" checksum="600F6371EA4461A3" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCR8</accession>
    <name>F9WCR8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15849" checksum="BC50DD0AE48FD40D" modified="2011-10-19" version="1">MVSLSFSRPLLFIRNPVDSRIQDAFDSKHQRLIPTQRIEPHHQGCDALLTQELHVSQITRRRIRQLPRHVLENVPQPSCIVNEPCGVLKEFRHTGLGRSRVAKTEATFFLQVLGERHVLPGLTSRLENALDVSPHSPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD14</accession>
    <name>F9WD14_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05870</name>
        <name evidence="2" type="ORF">TCIL3000_0_21880</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001799">
        <property type="protein sequence ID" value="CCD15162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002684">
        <property type="protein sequence ID" value="CCD17362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05870"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21880"/>
    <dbReference type="OrthoDB" id="1708225at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21242" checksum="7A45BC48A98EC682" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVEVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEANVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDNDDMPLEAIDEEIWRRCRRPPPPPYQPYQGVVLVEAAPAFIEVPYSTVGYLVQIPISPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD62</accession>
    <name>F9WD62_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001826">
        <property type="protein sequence ID" value="CCD15213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="AYLMNVL"/>
    <dbReference type="OrthoDB" id="1626327at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001859">
        <property type="entry name" value="T.cruzi_P2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="PTHR21141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00456">
        <property type="entry name" value="RIBOSOMALP2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="108" mass="10592" checksum="E2B315BF2046A89B" modified="2011-10-19" version="1">MKYLAAYALVSLSGKTPTKNDIEAVLKAAGVPVNSSRVEELLAEFDGKDFDALCAEGKAKLVGGVACAGGAPAGGAAAPASSAAAPAAAAAAEAEEEDDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD69</accession>
    <name>F9WD69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001830">
        <property type="protein sequence ID" value="CCD15220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57640"/>
    <dbReference type="OrthoDB" id="432197at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="25988" checksum="80337FEB31228C67" modified="2011-10-19" version="1" fragment="single">MPTIQESIELVSGYHPTESSPADEAVMAAVQHLKTALGNVSQIADGIRPVLKTLVRAAVLIPGEWSSVLQSLRDALDCPDLPWLHRAFLLKLLPEMLNDGSDAPRNCVEVCELLLRWATPSGETEDGRDGTQCSGTQEQRVALTALFSLPEAYFATIVQCCVSRLPPSLPMCLSLLTNQHAPNPLKLAFERWIVEAEASSLHGDCVAVIKKTLQEKYSGFGSLFCKDACAALIASEGLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDI8</accession>
    <name>F9WDI8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001875">
        <property type="protein sequence ID" value="CCD15342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58710"/>
    <dbReference type="OrthoDB" id="1673730at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389012" evidence="5">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="59"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="348" mass="38277" checksum="0E1394DD5A8D0F95" modified="2011-10-19" version="1">MMTAIKICVAACFYFMAVVVSINGKDHNRAQYNVLCDLVKVAVERWGNAGGSLSPPLREALGRTLFGSRGGGTVETLKKGLPEDYKEAEGKTSSRTTWCGKPHEKDLYYGIKQMRFPGHSATHDLVCLCTAGDHGWPKNSGSEKLCGKGPNELGVENKEQGWGIKGQGKDQIQATWTSVTKECLEGDGKGVNLKDALETFVNTLGTLVKGNNSYQPLGEGNFNSDYSCSGTKTQGVCVKYYPEEKLSIPWWKDLKQAIEAEEQEQKKDEEEEKRKQQGQHQHHTEGQEKLQNKNAPHTAALRSTPQDSTEAEQTNQENISSPLATLEEASGTIIAQPCSWLFSAILHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE86</accession>
    <name>F9WE86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_60780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001961">
        <property type="protein sequence ID" value="CCD15592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60780"/>
    <dbReference type="OMA" id="RSHAYPY"/>
    <dbReference type="OrthoDB" id="326653at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017085">
        <property type="entry name" value="RNA_edit_cplx_Nase-su_MP81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037001">
        <property type="entry name" value="RNA_ed_MP81"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="814" mass="87042" checksum="0472A9286C8D1BAB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN0</accession>
    <name>F9WEN0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 291</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002038">
        <property type="protein sequence ID" value="CCD15741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07530"/>
    <dbReference type="OMA" id="THAKAVD"/>
    <dbReference type="OrthoDB" id="1667040at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48423" checksum="D0C73E8685B88787" modified="2011-10-19" version="1">MTSTPVKLEPAKAKLKCDIISSVDDELVSLRRLMREECRRRLAGCVRKKQSVRKSLEAGPAPVTTHSPIGNAPCGAVGAARKKTSNVGPTALHKYRQELSEVQMEANLGRKRVPWFLARMPNRKLLVRDVRKPQPKNGDVVFTHALQSKLVSRSGTSPGRAAARTCNALQLYKKELRGFSDVYKNSFCRSSTCYRVAACRSEVAIRLIRSKSSGSVQYGTPPSKYDGKRVVFLDSKITGADNIGNAPHCPKNELFKGGSLENSRDVRGIDLTSHTPNPSPILQTQIMFSSCDYKRSELSNEVLSSSVRTGRMRPLETSIETLPFTPEEMVSSVEDNYTERNSLMKQCVSNAGVSFFDVSNRDAIISSLKSAGGHRVTALNCPEEPMRCEPSPLFVELLDQLANASSVTDDASDSTEATPPPRSIHPQPHPFMDTSADTPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEU2</accession>
    <name>F9WEU2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002062">
        <property type="protein sequence ID" value="CCD15808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00900"/>
    <dbReference type="OMA" id="KVKHMYV"/>
    <dbReference type="OrthoDB" id="1229499at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="149"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="271" mass="30948" checksum="C3C605187D59942C" modified="2011-10-19" version="1">MPSRAVLRKKARRESKRRKQEAEGTKVGIATNATTTVQRQERPHKPQPKPPAVEPRMGQRMKRARQGADEKEEDTTTDGVSRKERKRFEAKRRLERQLKALNRAEADCSAEVGEADGEAGSCPDAEAQRHDPKYKNGTFWRDRKERRKRTVFLGNVPVRFKEHDVESLVRNELRRSWVPSEDEGAAEADVIEGEVVESVDFLNTMTNARRRHMYVTMRSVELAECVAKALNGKQVEGIALRCNFAADKTERKEAIQRRPGNGGPLLSHQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEX8</accession>
    <name>F9WEX8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_08410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002077">
        <property type="protein sequence ID" value="CCD15844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08410"/>
    <dbReference type="OrthoDB" id="1674033at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389043" evidence="5">
        <location>
            <begin position="23"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="46"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38452" checksum="A135EB87E0DCB770" modified="2011-10-19" version="1">MSRMYSWMVMFWVIIGVQSVSSETDHNEKEHHALCEFLKVAVDKWKEVKARKPEDPLRKALKDTIFGYGGVEEDLETLKTTLPRDYDKVGEEGSSRSNWCGQPLSGEYQESYPRWPGQSAPHDMVCLCTAGSHGWPINETGKLCAQGKDALSARSQWWSGTNNTEKKDAIQKTWKIIVKQCLSESIQKQDLKKTLQTFKDKIQRKIEETETYYVLGENGTDYLSNPCDGSPKNGLCVKYYPTYKETQTWWKDLGEAIEKDEQLQKQRQEETEEQKEEAEQHSPKTEALNSGHPTTNQTEQNRNDNITNQLRRFNLTSGTFITPPSSWLLSALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF40</accession>
    <name>F9WF40_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 347</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002101">
        <property type="protein sequence ID" value="CCD15908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09000"/>
    <dbReference type="OrthoDB" id="1694337at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26696" checksum="11C4AB45F32DA4DD" modified="2011-10-19" version="1">MLKVSKFHNIELCLQTQWLATPLGVCVGLLSFFALQGFLVSRSQNYLVSVGSYMALGKTLCFLRYWHLTSAPFSPYVFIDVRSILSTGVLRAISYVSFFIALRELGPLRCAILWSATLLTVKCAAYSLSVLHAMFLFCTTLSIFLCCYEPLRLEKGVTLSLFLTIGGVVFSFLTFIVFDNSFPNSGNFCFLTYEHLFCSVLLPPAASFCPLVSMPFRVCYAAFLSRFRPRPVVLXFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFF0</accession>
    <name>F9WFF0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 380</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002137">
        <property type="protein sequence ID" value="CCD16018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09890"/>
    <dbReference type="OrthoDB" id="1707757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21415" checksum="E1662EE038626178" modified="2011-10-19" version="1">MNIYHSFMKAKPHDKEIVFGVNAIIKTILHRKCFVWYTVLDNPCRMAFRVELYSLLGKCASLSPFPPYDTFVAFPHSVVKKSIPRSVCSHKKIIFLQTNPKIQSSGSTRKSDGIVSDNCLMSDRVLVIDKVFLSSEGGWGYGLCMGWVIHCLKSLRVLLCLLLPMHASRRCLHAFPKKRWGERIKVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN5</accession>
    <name>F9WFN5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_10690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002169">
        <property type="protein sequence ID" value="CCD16112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10690"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394997" evidence="4">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="46"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37789" checksum="1AE6CC8470311D99" modified="2011-10-19" version="1">MWGNVLIVFILSHYSVKAVNCHNEVEQKLLCDIFRQSGRVLQKYEDAELIEEAIYGPTDNNAQIINFGNVTLGTSCHTPVLRDAFCRYLGGERVENGCFAESLLGTFFCVCAPGARRGYVDKLCGVSIKPHVDSWFGSIPLGQDKIEELFDSVWGYVIRNCTGVSESVGSGNEELEKLRKAVEEIENTIKPDRNGFFYLGGSVWKDCSGLNGRDVCAAYKKKDGSDSKAHIPWVEKIKEAITHLQKVERERQDLDFRQITAGKHGESITAPIPRAGEGNAELTDQSEGIVTPPNSNEAPSKTKISTKISPLSDIPHLATYFNENDSPLTNQKWLVIAAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN6</accession>
    <name>F9WFN6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002169">
        <property type="protein sequence ID" value="CCD16113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10700"/>
    <dbReference type="OrthoDB" id="1706204at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22394" checksum="B8E5288FAD2B1E9F" modified="2011-10-19" version="1">MRAMCSLTVAGNIPLSTYATTATVACADVPGFTSHAVSPQVRCKLSIFLQHAIPTPHTASHPTIRARTETNTRRVQKLWERHPIHNNTPTLSWSLCLIPREENNRTFNKGLLTTSEGSLNCTSCAAWDKEHLRPLEPLLLRPKAAAPLLLDVQPFSRHSTHCNLLPHLIHTNATCASFGCGFVGLLLITIQHAKETTPMLHGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFR1</accession>
    <name>F9WFR1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002179">
        <property type="protein sequence ID" value="CCD16138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10890"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390282" evidence="2">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="22867" checksum="8535BD5FFEC795E6" modified="2011-10-19" version="1">MTPLLTILSFLLPTPHPLSPPPIGISMSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYPFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREKVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFS3</accession>
    <name>F9WFS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11020"/>
    <dbReference type="OrthoDB" id="1695843at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="307" mass="35676" checksum="2780CC81BAE99C79" modified="2011-10-19" version="1">MGNFAKRENWQKNGIWQKGEFCKKWDLVKNEIWQKREFGKKGNLAKKGNLKKKGIWQKREFVKKGNLAKNGIWQKGEFVKKGNLAKKGIWQKGEIWQKREFGKKGNLAKSGIWQKKGNLAKRGIWQKRGIWQKNGIWQKKEFGKKGNLAKKGNLAKRGIWQKKGIWQKRGIWQKGEFCEKEKWNLAKRGIWQKGEFGKKGNLDKKGNLAKKGIWQKNGIWQKGKFGKKGKFGKKGEFGKKGNLVKKGNLVKRGIWQKGEFCEKREIGKKGNLAKKGIWQKRGIWQKGKFGKKREFGKKGNLAKNGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT5</accession>
    <name>F9WFT5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_11140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11140"/>
    <dbReference type="OrthoDB" id="1678516at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390314" evidence="4">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="71"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33265" checksum="3F8E5F0BF0584086" modified="2011-10-19" version="1">MVMIGIWVIVGVVISLSTPSRGTDHNREAYQALCDVLQAAVAALVSGGPGLGEPLRTALWNTIFGPDVEQNFETLKSGPPAAYETVVAHSDSRAMSCGRPFLDLGWLRRVHQVRWSGHSATHDLLCLCTVGNNSWPFHEASPDTTTLCGEGKRTLKAEKGEGWSAMGTGKKQIKATWDHVVAPCLKEGKGKDLKQALNAFLRKLVNQSMDTHPSRYQIGQGQPDPSDACDGTPSRGVCVEYYASWNVTYSLPWWWDLKKALTPPTPPAPDEPALSTLLSFFFNPSDTLFTQLLSWLHGAASWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG79</accession>
    <name>F9WG79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 474</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002242">
        <property type="protein sequence ID" value="CCD16313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12520"/>
    <dbReference type="OrthoDB" id="1740751at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="16885" checksum="4041720D815CF127" modified="2011-10-19" version="1">MALSCMEALATRRKGRAGGAANVPANGVTETNQTAASFRHPAIGGLSVASSVGHPNERNPMNAAFVAIKPQKPKLARALEKRQVHAELQKAKSLKPMGERGCQTVTSLSEAASRHQRRVAGYLPQHFACSRSFIGMRRSNTEAEQHLAGTTDATAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGA6</accession>
    <name>F9WGA6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12790"/>
    <dbReference type="OrthoDB" id="1700263at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="21253" checksum="A615B070EB7B51D1" modified="2011-10-19" version="1">MPFCLQSHSNEHMPSSLCGYSIASLMPPTLTSWWPLTVCIMRSWLHNCLPNWTCSSDMPSGRSHNMPMGRSYLMPLWKLNPMAPVGGTHADMPPSIVQGICLHDIPSHTRMYEFSPRDSLHTSKRSLTTPQFPECRHRLMKVETLAVGSLSKRIRPYVWPSPCHAFHGASRTPLCYLLYLGQSIADVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGG1</accession>
    <name>F9WGG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002268">
        <property type="protein sequence ID" value="CCD16397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1692334at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="14270" checksum="DAC1EE6D864DFA2F" modified="2011-10-19" version="1" fragment="single">MFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFHVIFSFPSPGALQNCFCNNYFVSFLVFRHPARCKTVFATIISCFSVSFLVFRHLARCKTVFATIISCFSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGQ4</accession>
    <name>F9WGQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 529</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002303">
        <property type="protein sequence ID" value="CCD16491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14100"/>
    <dbReference type="OrthoDB" id="1260827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19450" checksum="1C0B8EB0B6CE6F8E" modified="2011-10-19" version="1">MPRPFGTWAPATTLAEFRARVPDFRNFKLVWAHKGRREVYYHPDALAHFKDHQQYKDAVDTIRAMRVSDRFFGEGVKYPRHPFIKMAVILAMHGTLTYTCLRYYYGTHVPANNPTWRKIVNKEWEEAINNSPWDHMSHVWQYSDQYASSIGEAVSPGRRKFYIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT8</accession>
    <name>F9WGT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002324">
        <property type="protein sequence ID" value="CCD16526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14420"/>
    <dbReference type="OMA" id="KWEELCG"/>
    <dbReference type="OrthoDB" id="973998at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="726"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="765" mass="83133" checksum="BF7441AC4BB05CF3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW5</accession>
    <name>F9WGW5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002338">
        <property type="protein sequence ID" value="CCD16553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14670"/>
    <dbReference type="OrthoDB" id="1671362at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010090">
        <property type="entry name" value="Phage_tape_meas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10145">
        <property type="entry name" value="PhageMin_Tail"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01760">
        <property type="entry name" value="tape_meas_TP901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMin_Tail" evidence="1">
        <location>
            <begin position="113"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="383" mass="40353" checksum="11C5D0E1BAEB3E90" modified="2011-10-19" version="1">MGTRWALPLPEAVAALSAFAASTTRSVVPLTSPRPSKNASIPALARGETLKNKRGDLRGQAVETIGTGVALGAPVVQSVRTAIEFQDQTRDIAITGGFDEAEEKRLSYVMRGAALRWNQTQTEVAKGTGVLIAGGISSAKELAAYAPVMAKAATATRASMDDLGSVAIALNDNLGIGAAGLERSMNMLAFAGKSGQFELADMAKWLPQLTPQFAALGVTGERAVAEIGASLQIARRGAGTNDEAANNFKNFLSKITAPDSIKAFEKAGIDLKSSMKNLVNEGFSPAEAMIKILTVHLGKKAPAAAAQYGKALDLKDDQEKQIALARLDEAYKLGELFVDQQVLSFVRPALANQKDLGDIQTGSKDAADKGVLDEDWKKQNGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH44</accession>
    <name>F9WH44_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 592</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_15420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002372">
        <property type="protein sequence ID" value="CCD16633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15420"/>
    <dbReference type="OrthoDB" id="1665688at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="315" mass="34549" checksum="14B4F4677DC3C192" modified="2011-10-19" version="1">MLSRITQKAHNILDEIRKNNVSEEIEKVKAELSHVIFGAGGAESDLCNGSLKDVTGRGAACGNSGLHAKGQSAGNNLVVDFFCLCAQRNDDGIHDACKVKVGSKSEKHSWGDKAPSGSSSMWASIKKECENLLHQHPKSAKEGHEVIDDFWNHLKSGGLYRWGNTRKVDGSERKPGMLGTGAGTEGSGGKDVVCDGRRGYTATRGSGTPPGGICVYYGQEPQWEENIEWLKKLKTAMNTVDVLNNKTATIKRDIEKLHMLLHRAEKVYESAKLITEIQQPVLPTNLQTTAKRLTAYSASRRHHPNTHFFSLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA0</accession>
    <name>F9WHA0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002400">
        <property type="protein sequence ID" value="CCD16689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15960"/>
    <dbReference type="OrthoDB" id="271370at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="289" mass="32154" checksum="A64EA85454BF4098" modified="2011-10-19" version="1">MFSFSSPQHADVDSTVCNGHEPKMRTELEIPSNHHGHVEQFSSSAELLNILFTAAARWADGHPLSEAVAFAVLYEDVVYRRYARLQRIPELMAFLERSMKKRVEGADMPDVLAACVPTFEPTSLMLSGRRLHEKPLLDIRAPVYIPPLMAVPSMKLSITAELLRSSILAVLPPQESLKEIQELAESSSDISEKGGDGAGPQEMSRVGLTCNNFFSPSIPNTVRVLYILNSHGLAKPKAKQQFVHISLLQRLCQLSDESLVRSLLELQMNGMVTVNVREYKVKSTLLTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHG8</accession>
    <name>F9WHG8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_16620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002434">
        <property type="protein sequence ID" value="CCD16761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16620"/>
    <dbReference type="OMA" id="CFAGHEK"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390343" evidence="3">
        <location>
            <begin position="30"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="444" mass="48156" checksum="684B2BE4AB91B97F" modified="2011-10-19" version="1">MSKGTHAAPYALVLVLLCVVHPLQVAVVAQPGPAASTKDYIIFPNARFWNGGQYLVSHGATERICREEGAILATDHSEATDAAINEVYFKLRQRYIYSYLGGDAAFSASEAQDVGSRCKEADNSTSIHCVYRWNRGLFDATTTNGIGEAFWRGSYRSTPGAGSMNDFPFRWIKDYPKFGFLYPISRRHYRESKRTWFDEYEDTGHEAAHVVRKEKQVKNFVLLCNIYVPTTSAPVPQPESDENASEELNGTNANETESEELNGTNTNETESEDLNGTNTNETASEELNGTNTNETASEELNGTNANETASEELNGTNANETESEELNGTSANETASEELNGTNVNETESDDSSSGVSSTEAPAGKVNGGVLALAILLPIIAIALLLLLWYFCFRRRDEKEDAPLSLREVYSPAECPSPVEAPLTSEGGGAAEGGSPNASPVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHQ5</accession>
    <name>F9WHQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002475">
        <property type="protein sequence ID" value="CCD16849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01910"/>
    <dbReference type="OMA" id="ECNRANI"/>
    <dbReference type="OrthoDB" id="1363674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="447" mass="51087" checksum="0E5CCE210F4CF00E" modified="2011-10-19" version="1">MAAEENKPSQRIRVHDTALYTQLMNAADWSHIIESEGREQRNSLAKREAEIALLRQQEREKANEVKHRLELLMMTRSRRKKEEKQERKHVKEFRERMRTLRQQHNELASKCAAVCRSDVVRAQRALQRLGWQREELVLRPIQEAINEAISDDASSRFRAALRLKMIESYVEECNRANISASRGVFRDVFDPVLYNPFLQREMCTIRYPRPPQPRTVVDIHRSEAEEIEKKYEQLALDYRKLQAESLTGALSKPSLAAGPLHTLTQRATPSDEVVDFPVGQLSYFPRRRATSSSNPPELRSLKDPRGSTESGDTEMEPNRMRILPPLTRGPERSAAGACAVLGSEPSGGEVMPFLGARETENDRLVQWMRQRRRSVQTRFGDLPVTAWEHFPQTSLGWNTAPDGSTKAFSKRRVDFANYRQYSQVELAYYSGPGPCAAASCEGCCADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR4</accession>
    <name>F9WHR4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002477">
        <property type="protein sequence ID" value="CCD16858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17430"/>
    <dbReference type="OrthoDB" id="1703977at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="266" mass="28202" checksum="38B7E1570F7F4175" modified="2011-10-19" version="1" fragment="single">MPPRRHRRRSFVVPQNLQTTQSPGPAPAAQQLPAAELGTNTEATAAQREINPPQAVTPAVRPVDHVPLPDSATAPQPFGAAGRPVVTKTPPLNRQQEPLPVANEGGDKVTEEAQPEASASQEQQQQKPPVKNAKATTESPVEAPAVNGQAARAAPPHPQRNSRDFKNTKRYGRAFVPTPAPDRKATGAATVASTETSAQKTTVAPVSAAMEQMRLRQQCGTPTSTSAESVGLSDESEGRKDNKAEGFNNMNTRKKPADTKARAPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW0</accession>
    <name>F9WHW0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_17880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002490">
        <property type="protein sequence ID" value="CCD16905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17880"/>
    <dbReference type="OMA" id="LWGIFNS"/>
    <dbReference type="OrthoDB" id="326569at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12393">
        <property type="entry name" value="PTHR12393"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="583" mass="64784" checksum="1174FFEA169617F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW6</accession>
    <name>F9WHW6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002491">
        <property type="protein sequence ID" value="CCD16911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17940"/>
    <dbReference type="OrthoDB" id="1393300at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="839" mass="95165" checksum="1D7096210A385200" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW9</accession>
    <name>F9WHW9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 700</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002492">
        <property type="protein sequence ID" value="CCD16914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17970"/>
    <dbReference type="OMA" id="RYLACVN"/>
    <dbReference type="OrthoDB" id="125521at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1756" mass="190884" checksum="A816DB430177B392" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHZ5</accession>
    <name>F9WHZ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_18220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002503">
        <property type="protein sequence ID" value="CCD16940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18220"/>
    <dbReference type="OMA" id="PFRSMIT"/>
    <dbReference type="OrthoDB" id="1072475at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="30"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="593" mass="66337" checksum="0F6E14447453299E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI08</accession>
    <name>F9WI08_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 715</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002509">
        <property type="protein sequence ID" value="CCD16953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18330"/>
    <dbReference type="OMA" id="GGCEYYE"/>
    <dbReference type="OrthoDB" id="939345at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="PTHR22504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28391" checksum="86F21A31A5B1E13A" modified="2011-10-19" version="1">MEFVPLESFEFLNSLLHSVEAQDCLMTVRLEAFTCRCTRKKKQLAASIADYANKTTPPLRPACPVGLPAPPLLNLSDEGPPTTQFEAVEHVEPSDIDDRLVFLVAALNSIYGEDGYDFSVLTEKDFVTCDEAHVRAEVNSTLRSLPPSCSPAVEQFWARVSEQTSDASQGCEYFRFSSPSCDPMASRALFSQHYFLYNKRTRLLVSLLVFAEGNLYRSDDGCAPDNHLYYDGYSSSSKSPLWPDGPGGASRDGECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI86</accession>
    <name>F9WI86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_18900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002544">
        <property type="protein sequence ID" value="CCD17031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18900"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389167" evidence="6">
        <location>
            <begin position="19"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="97"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="281"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="384" mass="42689" checksum="71C6657AAD7111DB" modified="2011-10-19" version="1" fragment="single">MVWFTDVIAAFVMVVVVGSTVSCQKELEIEKDENIEPFALLCRIYNVAKNPPINYVDLQEADDIVKEIDALNTSVSEEMLFNESKQLWNGVDTQNLPTSAREAALAQLSLNQITQKAHTILDEIKSMSLNKAIEKANSQFSQVIFGENGNETKLCQATVNDMDNRSKECGMPREGRKGDSAGKNLVVDFFCLCAMRTESSEGAKHACGFFVGKIDKYYGWSEQGPWGSSTMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLKTGGVYRWGSGNEVKGSKRKEGMLGTGVGEENSVDKEPLCNGKNGKTGKPPGGVCVYYGPDSDSWERNIDWLKKLKTSLENVDSLNNQTATIQRNIQRLQTLLQRAEKIYETTKVITEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE4</accession>
    <name>F9WIE4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 77</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002576">
        <property type="protein sequence ID" value="CCD17091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NTTCALV"/>
    <dbReference type="OrthoDB" id="458757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="509" mass="56774" checksum="9B1E67696232E9BD" modified="2011-10-19" version="1" fragment="single">MKRTDCNIVERLSTAQQKPTSEPHRFAVLVIGAFCSMCTSFMYAFNLVSGAMQSRYDLTQRDLSSITTVGMTFGYFLLPYGFIYDHFGPRPIFLIAATSFSLGTLLLALTFQDVIEGSLTRLCVYNAFMTLGCMLFDLGGIVTVLTRFPSNRGAVVAIMKTFTGLGSAIVGSVRLAFFKNNTSHYFYFLMGFAVAVGSLAIVFVRLPPFHLTGYEENHLSDEEKEQRRSRKAVYLKQKAPLWRFIYGFVLLITLIVFLPLQGALLAYLQLGDSFKVGFAATVIALTVVFPFMAIPIKIFDHAAAEEDKTPTENARSEELPSVEDAVETDVDYIAPQFQETFIESLRTVRLWCLLWSIFCCVGVHYIIIYNARFIYTALAGEVPDDALNTLLTVLNGVGSAVGRLLMSGFEIWTQKRKAEDRIPITVALFVPSCCIITMLTLFLVLPKGVLPLPYSIAAVSNGFMAAAIALVARTMFAKDPAKHYNFCFLASILSIIFLNRLLYGEWYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK8</accession>
    <name>F9WIK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002612">
        <property type="protein sequence ID" value="CCD17156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20010"/>
    <dbReference type="OrthoDB" id="748733at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="23615" checksum="C8E6664016C9DCF1" modified="2011-10-19" version="1" fragment="single">MLSWRSHGRCLLSRRRYLNRSSPHNLDKLRRAAMIESAVELPPYARSVVQVKPLVPLSSSIGTIAMLKLLDEAMEAACDARYGLHGRSSGGGASGACRASSLTHFISECKRLRRAMGECRDRENRLLLRGSLRSFWAENVDGAVACCAQRGRDLGFIAGLGLADDSLHVNFELLKFIVVCIMKEKHTCACVDMMLALHYIARELDHVECFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIM0</accession>
    <name>F9WIM0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20130</name>
        <name evidence="1" type="ORF">TCIL3000_0_52180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002617">
        <property type="protein sequence ID" value="CCD17168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52180"/>
    <dbReference type="OrthoDB" id="1715555at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16719" checksum="3E416042331975F8" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTHAPCRRQKPQCGQQLLHAFGFHHVPRVPGCAWCRAVVVTLACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIM7</accession>
    <name>F9WIM7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002617">
        <property type="protein sequence ID" value="CCD17175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20200"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16645" checksum="4E20686C050CB8E5" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTPAPCRGQKPQCGQQLLHTFGLHHVPRVPGCAWCRAVVVTLARGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCSTVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIR7</accession>
    <name>F9WIR7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="4">eIF3i</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_20520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002629">
        <property type="protein sequence ID" value="CCD17215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20520"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="OrthoDB" id="866359at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="37952" checksum="E93D45570F1DEBE3" modified="2011-10-19" version="1">MNIQGVALHGHMKPVTMIKFNREGDLLFSTAKEPDVSVWYTKTGERLGIYKGHSAVSACDVNNYSTLLVTGGMDFKAKLWCVESGDELANIMLKSPARAVGFSHDDDKLMVSTSRKMGEKSAVQLYNLPFVPPKNDYIVQPVKTAFNPCAEFISECDDITFAVWGPTNDTIYYSMSDGSVAILDVETMRTVRTQQPHEEMINRIAFDPNYYTLITASKDKTARLLDSRDMSTIQTYTSDVPVNDASISPCGDHVILGGGMDAQDVTTQGGQTTFEVKFYHKVHEKQLGQVRCHFGTINSVCFFPDGRGFASGAFDGLVKLHRFDDKYDSTPGAQPIWRPQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT4</accession>
    <name>F9WIT4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_20680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002637">
        <property type="protein sequence ID" value="CCD17232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20680"/>
    <dbReference type="OMA" id="VHHIKEN"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="43870" checksum="3C6770E40BEF5281" modified="2011-10-19" version="1">MLVEKPAVLFRARKSRISVYMLPLMTLLALAMVGYTLYGIGNGDHTPEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDVDGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRRRIGEGGSWGFQSEVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRASLLWTTDDIVFAAGYCTTLSKDAAQAVVSYKPLAALLSKPYSIWHMMQYSSMSVMHEDIMVGRVLREKVKFEDLITVDMRSCKFHESGRRGIFTTVTQKSVVVHHIREEDYQRLWEWFDDNGRSHVPSQLHWFSETNAIVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW2</accession>
    <name>F9WIW2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_20940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002647">
        <property type="protein sequence ID" value="CCD17261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20940"/>
    <dbReference type="OrthoDB" id="1675706at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390449" evidence="5">
        <location>
            <begin position="28"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="56"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="362" mass="39515" checksum="12C8F25823DB6E50" modified="2011-10-19" version="1">MKLLSRLRVSNLVLCVLWVQVVLGAQAQDSKNGFQVLCDVLRHAERVLNSADRNRVALKEALFGRNNGVLAVEKGQVSVKGACNYQTKRELLCTYYAGGKHGCFAQTLAGAILCTCTPDQRGGNFCRFGALNSGGTWSSGWLENQKDLFQKVWDQVKEKCSSEIGSDPTHTEPLDDLKDALDKVRGNLSQADRNSFYLGEPNCARKYGSKSCVTYLGKDRHHVHIPWLDTTQKALEDLKQASPREAILVQTTAPTTGTSPAPKESAPKNPEHLEHSSTPNTTTEREHTEDTFPPGTPSPPENQPSPKSRTRRSTTEDPTAISTAPDDSVILDPTVAPFSSPEGDSTDILTPLGLFMAASSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW5</accession>
    <name>F9WIW5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002648">
        <property type="protein sequence ID" value="CCD17264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14616" checksum="B770B7D0E9F66C8A" modified="2011-10-19" version="1">MVCGMAGTHCLTCSVISAKHNERKYHRSSASFPLHGHVQGPLPPHTSECRKAIAFTHWVTHAPLKHTTTHFIPSLPLTHGPTLPSLHWPWRVLRSLQSFPLARLSNYNKREMASRPPVTTAHPLGPMAASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ9</accession>
    <name>F9WIZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_21280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002667">
        <property type="protein sequence ID" value="CCD17300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21280"/>
    <dbReference type="OrthoDB" id="1667119at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="94"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="416" mass="46149" checksum="4B3C1FC0AC059D38" modified="2011-10-19" version="1">MTLVLFLLFCQGLERKMMKLFMVMMLVMGGWVRHWRVMANAAVSVNEGDNKEPFELLCKIYNVAQHPPIKPVDTKEYQKIVDDINALSAAANGKERVNTQTEETKSAQTQLTGITHEAHRLLGEIKKVNPEGQAEMARNTFNQVIFGKNGKEDLSHKALEVVPSRMAACGSKPLEKKGQSAGKNLIVDFFCLCAKHDVEDGVDKVCGVSVGNGRDSRWEGGTLDSANTMWDEVKNGCEKFSKHGVTSTQDGYSLYNDFLEKVKVGGNVKVKDSSTTPRHGMLGTAVSETGKNDLNCNGKKEVSSGGRFTSSAAGVCIFYGNHHQEDNIAWLKKFKEGLQLIDKLNTETAAWQHQLTTLLNRARELYEKVKADSQLEEEKTQEPTEAQHPTTDENENADSATQSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ09</accession>
    <name>F9WJ09_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 859</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002669">
        <property type="protein sequence ID" value="CCD17310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21380"/>
    <dbReference type="OrthoDB" id="1662607at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="752" mass="79439" checksum="EEFE96AF55245D68" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ48</accession>
    <name>F9WJ48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 872</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002683">
        <property type="protein sequence ID" value="CCD17351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21770"/>
    <dbReference type="OMA" id="AVYPTVH"/>
    <dbReference type="OrthoDB" id="1575622at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19484" checksum="BEEA02CD08B98481" modified="2011-10-19" version="1">MMMLHCFFGLEIQADGVSLTPPMPAESSLVLTHCALTGTQPGAVTLYAQSHDQPARFALCTLDAGRDMFYAPLHHVFSQKVSFTLVRPSAVKDSDGGEVPTMHLTGYFERSEEEYPEDDEYDTDDETVEDNDDTTGGARGAKGASKARNGPNKSKLQNQQKLAEGNRQVSGEKRKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB1</accession>
    <name>F9WJB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 892</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_22360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002705">
        <property type="protein sequence ID" value="CCD17415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22360"/>
    <dbReference type="OMA" id="FVFAGHI"/>
    <dbReference type="OrthoDB" id="1311668at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="191"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="451" mass="49354" checksum="7F3EA69F8FCB6EE4" modified="2011-10-19" version="1">MEQKAEYPGSNGSMFAYCVLNEAARKLFGVSSHEFYWKRMGLFVKADTMKDLAALIGCPLESVQDTLGEYERLSSSQRSCPVTRKSVYPCVLGTKGPFYVAFVTPSIHYTMGGCLISPSAEIQMKNTSSRSPLSHSNPILGLFGAGEVTGGVHGGNRLGGNSLLECVVFGRIAGDRGSTIQQKKQNALSFTEWTTVVLREVREGGMYGAGSRVLRFNLPGALQRSGLSLGQFIAIRGDWDGQQLLGYYSPITLPDDLGMIDILARSDKGTLREWISALEPGDAVEMKGCGGLVIERRLSDKHFVFAGHIINKLCLIAGGTGVAPMLQIIQAAFKKPFIDSIESVHLIYAAEDVTELTYREVLEERRRESHGKFKKAFVLNRPPPLWTDGVGFIDRGILTNHVQPPSDNLLVAICGPPVMQRVVKMTLKTLGYNMNLVRTVDETEPNASSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJE1</accession>
    <name>F9WJE1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 901</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002715">
        <property type="protein sequence ID" value="CCD17445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22640"/>
    <dbReference type="OMA" id="YLQARCR"/>
    <dbReference type="OrthoDB" id="1259586at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="21092" checksum="118738812DFA7D89" modified="2011-10-19" version="1">MAKKKPPCPSVNPQLYEKCQKPSITVAMGMKGSACSTSCWRAQVEKEESLRAAWAKKYDRQSEIQLINAVERTLQREKNVGDMYREGNDALKVMLSSKNDGGGGRLTAAYLKSRKARAPQDKYPRAQTEAQEVGWYLTEAEHAANSCFSRKLPYVNSRGLQMAYRRPGDEDHAALFGYSLSCSFPSGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI4</accession>
    <name>F9WJI4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 914</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002729">
        <property type="protein sequence ID" value="CCD17489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23070"/>
    <dbReference type="OrthoDB" id="1719486at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18588" checksum="F2A97991A4B1D7BE" modified="2011-10-19" version="1">MSVQRSNEASDKLTHQVASTPSTQRQPGGTEDSEVREVVWKVFKSWEGACLVDFLTQECGKTHGTCNPNVALAASLEDPSHYIEEDEEREEVVEKLPGKLHHMKGCIFRDVPFLRAIGITTCEQWAYRRFYHEMLTPIANYILLRACGSPLDGGTNKEDTQIVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJL3</accession>
    <name>F9WJL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 92</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002742">
        <property type="protein sequence ID" value="CCD17518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1049789at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18772" checksum="4F9A107D8E8A5F01" modified="2011-10-19" version="1" fragment="single">MIVPRPWEVGGWRKLPGPVGNTFEDVFWNAVGAYTGYSVDEFQSMLDAGAKLNASITFGAESVHEKVQPVVPARLVGDQVIRPIAPLSALPAVDICESEEAIMKLRSRCFQYTESIAQLLEATRNCCGHWGRLRRAQRIQLLRALSSEQKSRFEVDELCLYFTDLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJM1</accession>
    <name>F9WJM1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 929</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002746">
        <property type="protein sequence ID" value="CCD17527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="930" mass="102900" checksum="594CA41DF3ACA902" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ8</accession>
    <name>F9WJQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002755">
        <property type="protein sequence ID" value="CCD17566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="66074at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="35282" checksum="ADB5B04AB1C385C4" modified="2011-10-19" version="1" fragment="single">MEAFIEAARRAETLAAVDFAPVHEFIQNVPADSGSALQGAIAALVDAYSAADSSQLVLQCALMKCIGCILRSAAAGGRLSLEVDDYILLALFFNEISTVGDAQLFLLLTEAVTPLFQQSVALVFGPAGCGAEECSPIAPLRGELQSLWLAMARRLVAPANALESVGKQREYHGTEMLLGVVDCLRALLLSLLQAFACDGAASGEEEEGKRRECNESVMQAVCQVVEGVLLPLTHAVESLRPSSVSNAAGSGGGKSLPGLRPSGSHGETVSPLVLVASLRVLEELTWRCAGRGEGDPVADVGRFAVSRLLAIIQQYLVLQQQKSMKSVGMESQEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR5</accession>
    <name>F9WJR5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_23840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002760">
        <property type="protein sequence ID" value="CCD17573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23840"/>
    <dbReference type="OrthoDB" id="1674573at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395118" evidence="5">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="38429" checksum="658977082E5CED6B" modified="2011-10-19" version="1">MMKVLFFVIVAIFGVANATADGEKDHNEAEYRALCGVLNAAVNELRSGLESHSEPMRTALHRTIFGKDGGGSLDDLKSKLPGNYQLPDGYSTRPFFCGQPKQEKVNDKESHALWPGHSAPHDLLCLCTAGDGGWPLSASDAGKVKLCGKTLSDLGGEANLGWFRQQSGEKQIQATWTSVTRECLSGNGAETSLQSAMDAFKTKLKQNTSSSKHKDERLLGEGKFGDYPCGGSKQICVMYYNTTDNAKHKPWWKELEEAIKIDEQMQKTRKEETRKQKEIEKQKESYKQETLQFPRSPRTAAITSAPQGSQDAEQENPENISAPIATIEDASGTLLIHSCSWFLGVLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJS1</accession>
    <name>F9WJS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 944</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002762">
        <property type="protein sequence ID" value="CCD17579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23910"/>
    <dbReference type="OrthoDB" id="998390at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17568" checksum="9D21545B8581E648" modified="2011-10-19" version="1">MEGLDRAVESAIANYVERNKSKVMKNPSNVFCQALRKVLGKMELMMLTNDEIAIEEEREALRHYIIRNKRQLHTTEDLLSAMQYVKGISNRFGSTGGGAEGVEAAVLSDPKVISAQEQLLLWRHAAAIFLVRQQAKDALNSYHLLLAETLTKVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK52</accession>
    <name>F9WK52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 986</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002809">
        <property type="protein sequence ID" value="CCD17713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24990"/>
    <dbReference type="OMA" id="GREDHPM"/>
    <dbReference type="OrthoDB" id="1098256at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="41605" checksum="1E0FC6FCAFDB72A1" modified="2011-10-19" version="1">MQSSDGSFAFPILAPHTLPLSGVGSSKLLRSISMRCTLLRRAGFLQNLKPEKNNFFTNLWNKPRTRDESIKSYVPDVIEEGLREQRAVLQENTARDVVVELGYKVLSEIECKRPTPSIAPHLNKILTQYGYKDLIAQRPLSYLLYPCSTINTGHQPHELVLNFTENFRSFVEEVERNGCSLRNKNQNKEEQTAESGKVSTVPTPDVNGADAIPSDMTSDTLKSGPVIMASADKHEPMGVTLFIRILSGMSIANVQSGDLASAVRCVDAGLEYVVEPSRRGALLGMKSGILVRQRKYEEAVECAMEAVQVSGNIQGYIQGAFAMHMLHRLEEAVKFLERGREDHPMNTQLLDLMDKAVKELEQQPVVEETAKITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3C3</accession>
    <name>F9W3C3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1036</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_26010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000391">
        <property type="protein sequence ID" value="CCD11633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26010"/>
    <dbReference type="OrthoDB" id="1155557at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="34525" checksum="D8F12D66E23650C7" modified="2011-10-19" version="1">MQPTLPKNSEEAKNLARSLRQHADNKICFDCPQKNPTWCSVTYGIFLCMDCCGRHRGMGVHISFMRSADLDSWKPEKALRMALGGNAAAASFFQQHGGAADSRQRYVTAVAQSYKSRLDRLVAERMGEGSTMAGAVVSTARRGEGECPPPSSPRPQHQEREEDGGAFKDSTTNIGGPVQEPTMVTMSSKSVRQRAGGSLKKKGFGGALKVEGHLTESSRKVPQGLMCDVASPHVDGDGCNDNITGAKFGSCGSRCAGNAGDNATGGKKKTERCVDGSLKDGSIRKSNTGPPEDRVPDFSGMSSQPYDPHEAVADADGAYFNTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3C6</accession>
    <name>F9W3C6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000393">
        <property type="protein sequence ID" value="CCD11636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26020"/>
    <dbReference type="OrthoDB" id="1684114at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394656" evidence="1">
        <location>
            <begin position="30"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="37601" checksum="BD20138A40F9EC67" modified="2011-10-19" version="1">MLVDRGACANCVCVFIVMVMLSVPRLSCCRATEGALWPLKECAVNLCAVRRSLDNVQKAVDAIITTMGERVGEVKSLLKVVEMRREATAHLAATARRRAGGFRLASLIVTRVNAAVASTTRLMEETEKVYDEILSLSAAAKVRANGALDNATAASAIIFSILAKTRDAGNIHIGTGECIAASTDPVLTSRALAAHKESLAITDKKYGSEYPILREAWARVYPKLFVSLVQAEFLLAHLESDGSRAAELVERARASVRAATEAQMAARNSAREAEADASRASWARRESIREAKKTAAFRVVTGFREPSNLIKGTLVNETGISEGYVANMCFSRGGAAQALALLAALTRTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I9</accession>
    <name>F9W3I9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000416">
        <property type="protein sequence ID" value="CCD11707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26610"/>
    <dbReference type="OrthoDB" id="1684997at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="292" mass="31514" checksum="B20D61C44E086E35" modified="2011-10-19" version="1">MTLSEVISGFVKITLSAVISGFVKITLSEVISGFVKISLSEVISGFMKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKISLSEVISGFRKMTLSEVISGFVKMTLSEVISGFVKMTLCEVISGFLEMTLSEVISGFGKITLSYVISGSVKITLSEVISGFVKITLSEVISGYVEITLSEVIPDIGKITLSYVISGFEKMTLSEVISGFGKITLSEVISGCVKMTLSEVISGFVKMILSAVILGCVKMTLSEVISGGEHGYVSSERCLVEDESFSLREGRWIRRPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3K8</accession>
    <name>F9W3K8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1070</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000430">
        <property type="protein sequence ID" value="CCD11728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26810"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394539" evidence="1">
        <location>
            <begin position="18"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16527" checksum="DEFEAC35E080FE28" modified="2011-10-19" version="1">MVMMFWIVVMVVTGVSAQESGANVKDHNREVHDRLCAVLKAAVWKCVNGGEGLLEPLRNALRRTIFGNESGWNPEDLKRSLPKDYDEVLTGGGSRSAWCGGRDSGHSAPHGLLCLCKTGNNGFPLNGGTGKEKLCWQVKDALGGGAVGWGSQTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L1</accession>
    <name>F9W3L1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1070</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000430">
        <property type="protein sequence ID" value="CCD11732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26850"/>
    <dbReference type="OrthoDB" id="1692343at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="249" mass="28144" checksum="0DDA8BE8BAEA9A5E" modified="2011-10-19" version="1">MVNNQYEGWYAYMGYGQNKGLEKSWKTVVWGCLNNRKDKGREGSQDIEEKLKRLNTTIWNFTRIPSHANGRHKRGGYNDHHTASDGSDEKRIHVHYDTCDQLKKPWWKKLKEALKGKTETQLLVNRSAVTNTQDPLTPPPEEKGNTMLTAAEEGVPIPPPSPEDPTGGPTTEEEGGNGTVHMTQSDGLRNNSTNSTEHHRIRHPGQGGKLQCTFPVSQDQLPHNPTTLAFHCFFPNLEHTRNEIKPPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M6</accession>
    <name>F9W3M6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000438">
        <property type="protein sequence ID" value="CCD11747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14413" checksum="AAD422B34C7255BA" modified="2011-10-19" version="1">MASSNMHPPPLVQEEGPRAGIVPYVRKASTLGTAPARHVVDSAVEEAVHHPGNRAAIERDANKRQRRRPVTVHETVRPIDRVQEHADAGAQFLVCFSTNEPRFSAGVSIQVRLERNGEVSDKKPPHAVIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3S0</accession>
    <name>F9W3S0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000460">
        <property type="protein sequence ID" value="CCD11793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="86440at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16324" checksum="A1211DDA8DCEBCAC" modified="2011-10-19" version="1">MASVKSLTLLTDFEASAAGGKKFGYHTSKGGPTGALLPLQDTIRRILFSLPAAFSEVLRCMIGQQEASGENIYVPMSIHQQHFDDCGLIITMGRLKAIEKELTSNRLAIFDAAENKLMIPQHRKLLRILDEVSEERENARAGGGRPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W417</accession>
    <name>F9W417_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000504">
        <property type="protein sequence ID" value="CCD11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1686745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17066" checksum="CFB5B6D532356959" modified="2011-10-19" version="1">MEYLEDRNPEQLIAAYQYMSPTAATPGPAYTEAWKNFVSWALGLRSEGISEGHLQLGRQLYNQLRTIQTVKDHPGVKIEDIREAVEYPHRKDDVFIQAALKAKRHQTAIPPGRAQCFTCGRVVHYSSSCRVFKKKPESHPTNGFRPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W450</accession>
    <name>F9W450_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000513">
        <property type="protein sequence ID" value="CCD11934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28710"/>
    <dbReference type="OrthoDB" id="1731830at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="22880" checksum="209DE0093101C647" modified="2011-10-19" version="1">MCGTCSGHFFWFTNTFFTKKFSGTFLKNKNKFKNFWKNLVTGSNSPMSNFFALGAIFPIFQKTKKIAKKRQNVIKKLIKPFFDARNVFRTLFLVYQHIFHKKIFGHILKNKNKFKNFRKNLVTGSNSHMSNFFALGAIFPIFQKTKKIAKKRQNVIKKLIKPFFDVRNVFRTLFLVYQHIFHKKIFGHIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W463</accession>
    <name>F9W463_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_28850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000519">
        <property type="protein sequence ID" value="CCD11951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1656891at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="322"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD11951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="667" mass="74695" checksum="EAF09B3698FAD43E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U6</accession>
    <name>F9W4U6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_30980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000607">
        <property type="protein sequence ID" value="CCD12192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30980"/>
    <dbReference type="OMA" id="ATESHAK"/>
    <dbReference type="OrthoDB" id="1665017at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388679" evidence="5">
        <location>
            <begin position="24"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46043" checksum="4149642E62BEFF23" modified="2011-10-19" version="1">MFFKNRIILETALLYGFLLHVCGQIKEGSNAKQYGILCDIYNVAANPPNSMYDANHVEKIKKKIYVIDASLSDDSWLGETSEKDTNGNVTGELKGNNSNGASNWHELKHDVASVASNYTGFQNILSTKTFVSRAQRKLKKIVSQMEKVIKNVQEANTAANLDGIKKDFEAVIGKIGEQTTKEDRVALCGNPSNNKAGTSAGKFLILDFLCLCARPCISDKLPNVCGPDIKENRWDKTTGDGRSDEKGEETWKILKEGCENRGSTKLADPNAGYVALGEFLTAVSQDTVTTYKDKPGIFGSVYNQRGSGPTGGCTGRGGEGHGACLYYGNNGKDGGRNIPWVQKFKSGLEKLKKFQNITASVQSDIMLLKMLQIRAEEIHEDTKAILELEKSNHEEATSHSATLNHSYHISLFFPWSLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V0</accession>
    <name>F9W4V0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000610">
        <property type="protein sequence ID" value="CCD12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31030"/>
    <dbReference type="OMA" id="DVRYDWP"/>
    <dbReference type="OrthoDB" id="710636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="476" mass="52541" checksum="048A90B0F2DE50BC" modified="2011-10-19" version="1">MTGLVEELPLSRAKLPGLHATGCTGREVGPGSYDIKLDYGKFHHGVAPFGCASKRFEENQGRMVPGVGTYDILPTNTRKANISVIPFRSKVFRFQAYGGDDAPGPGTYSPCENPVRRRTRSHMIGFFRQEGPINGDTPGPGSYISHEYKKKRLHPGGIRFEAYSGRGPLQSNEYPGPGQYEYRDTDNSIYSRKPTISFASKTERSHNGDNGNPGPGAYDLPSVFLSKEHHEAANPEPLLAFCTKAARYLSSEKESYPGPGAYTGEIAPRRPQLCNEKKSVRSFAVTLGHTKPPARSNLGPGTYDPEKPRKGPKYQLGSVAFCSAVDRFPPLKFKEEKTDFIPRRDTERAPRRVHPARVLSDVIFNMIKPRKEQPFVNYLDDDRYDVIKPRCMGGGYLGCAPRFTSAAGKSWSPGPGQYNLPDNSSAVGKLSQCGTWGVDGRFKRHLVENPGPGHYSCDATLLKKSFNRTVNQSDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W526</accession>
    <name>F9W526_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1266</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_31730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000647">
        <property type="protein sequence ID" value="CCD12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31730"/>
    <dbReference type="OMA" id="FEGKCHF"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="363" mass="39936" checksum="8404003212404BA1" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVTVSTGKAPDAVDWRKKGAVTPVRDERLCDSSWAFSAIGNIEGQWKVAGHELTSLSEQMLLSCDTREDGCGGGLMDRAFQWIVSSNKGNVFTEQSYPYASTDGDVPRCNKSGKVVGAKISDYVDLPQDENAIAEWLAKNGPVAIAVEATSLQRYTGGVLTSCISEQLDHGVLLVGYDDTSKPPYWIIKNSWGKGWGEEGYIRIEKGTNQCLMKNYASSAVVSGPVPPPPPPPPTFTQEFCEGAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W567</accession>
    <name>F9W567_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1281</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000665">
        <property type="protein sequence ID" value="CCD12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32080"/>
    <dbReference type="OrthoDB" id="1700656at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22237" checksum="C2ED04770C579655" modified="2011-10-19" version="1">MVGRCTAVRVSHDTRQGPSVPRCRCDAPLFSRYGQPELCRPVVSYFPPQQRTSLQYRFSGCHSGRKQTERTGPLLTAPRVGLRLRRISARCISPLHARYSVPSRAKVSLEKQPLLSCALRSVQYFSLAFPTPLPSRHTVSCRCLLACSLPMPPFSRSYPADKPELQTVHLITLISQPTPVDHSPQSFHSPHAVHFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5C7</accession>
    <name>F9W5C7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ribonucleoprotein p18, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32610</name>
        <name evidence="1" type="ORF">TCIL3000_5_1650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000697">
        <property type="protein sequence ID" value="CCD12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_1650"/>
    <dbReference type="OMA" id="TWVMKEC"/>
    <dbReference type="OrthoDB" id="1261926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="21294" checksum="E7A4BC670D248624" modified="2011-10-19" version="1">MMRRVYSPAFCGITAARFAATTASKKYDLFGYEVDTNTAPWIEKIKKCKFYDEAGEVLVNMNVSNCPPDIATYNATLQRIYEAPSKQSTPVENESKFCAMMDLLEEMQHRNKLKPNEESWTWVMKECVKSGQFRLGYCIQQVMETECKGCPADLVKANEANAQKAKAEGKEHPSHLSQQVGLFDVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5T7</accession>
    <name>F9W5T7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_34120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000768">
        <property type="protein sequence ID" value="CCD12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34120"/>
    <dbReference type="OrthoDB" id="1295967at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="PTHR12415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19971" checksum="60D0FCAB82FFC5AB" modified="2011-10-19" version="1">MNLLCPFWINKIPRLRTDSPSALSLADLLYCNVEDPNEVWTHVILGGYVMDVEWLFRVSDPLLMSKCTIVLISGEKGFLHKYRHLVLHDRFGRNRVKIVEPCLPIPFGVHHSKMMLCINNNGIRVAVLTANFIEDDWNYKTQGIYFFHSPRLGSISFYITLCTPFIDFFGCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5U0</accession>
    <name>F9W5U0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_34150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000770">
        <property type="protein sequence ID" value="CCD12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34150"/>
    <dbReference type="OMA" id="KFQLEQC"/>
    <dbReference type="OrthoDB" id="1654096at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="402"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1141" mass="132769" checksum="63DEA35AEBC34083" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W605</accession>
    <name>F9W605_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000806">
        <property type="protein sequence ID" value="CCD12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03520"/>
    <dbReference type="OrthoDB" id="930815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38288" checksum="BC97F33790149921" modified="2011-10-19" version="1">MPMSSSEATSGKPVLLPPGSYVLLWTLPLVLSLFIFGIARPAVRVHPVVAVSGAASKHSQQWWLVQMHLGVAACLLFYYMYVACAYLLLSLKALRRLGMVPLHNGTYGWCVNELRRILRCGSNFYGWFDEVCDDYYLPIIPFPSFLEGNQTQKIYSSTEKPLSRSHLLYYRLVVLLALLLTCATLFYLSHTAERFCIPQMVMAYWRPRPAVGEEGECGGESKDEEEGKEVAADYLEFLTNDAEWWSMGDPDDSWIDSPEARMEERRWEDMDRNESRKHFKGQESRSPRSVLTECLLPLLFVCYAGLYALCGGMALFMLWVYPFFVVLLIIVSLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W652</accession>
    <name>F9W652_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000823">
        <property type="protein sequence ID" value="CCD12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35160"/>
    <dbReference type="OrthoDB" id="1281266at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008981">
        <property type="entry name" value="FMuLV_rcpt-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="PTHR10424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49830">
        <property type="entry name" value="SSF49830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18430" checksum="66CA9B419FCCEA34" modified="2011-10-19" version="1">MWGGHQITFVVNGTCETTGEAYWKPSSDWDLITVKRGSGYDKSNQGERNPYKYPENGCAFKNSPPGPCKGKYCNTLLIKFTEKGKQHRLSWLKGNRWGWRVYIPLRDPGFIFTIRLTVRDPAVTLVGPNKVLIEQGPPSRTGSPKGPGCTSSTNSTAQHSGTLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W661</accession>
    <name>F9W661_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000825">
        <property type="protein sequence ID" value="CCD12665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35250"/>
    <dbReference type="OMA" id="GPFLGMG"/>
    <dbReference type="OrthoDB" id="1276149at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="643" mass="70584" checksum="7767C6145F59EEFC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6F5</accession>
    <name>F9W6F5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Katanin p60 ATPase-containing subunit A1</fullName>
            <shortName evidence="1">Katanin p60 subunit A1</shortName>
            <ecNumber evidence="1">5.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">p60 katanin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">KATNA1</name>
        <name evidence="4" type="ORF">TCIL3000_0_36140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01000860">
        <property type="protein sequence ID" value="CCD12760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36140"/>
    <dbReference type="OMA" id="MRASNEV"/>
    <dbReference type="OrthoDB" id="717356at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03023">
        <property type="entry name" value="Katanin_p60_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028596">
        <property type="entry name" value="KATNA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Vps4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="301"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="309"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="553" mass="62291" checksum="A49F5992DD91BDAC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T7</accession>
    <name>F9W6T7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000936">
        <property type="protein sequence ID" value="CCD12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37320"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="17893" checksum="4EBB85A0AC1B03E7" modified="2011-10-19" version="1">MRHISWRVLSPKEAGGRRARAPRRVGAPSQIPPDMRSNAAHGSFEKHAHVSSEIHTLPPTDTHGGDVPLASFTPAVAAHNACQPAFPKTSARVSRVRSSAAGFSPNTITGWQALTSRECGRHCPEACSSSNTSPAISQSPRRSARRHGGSTHGSLASEFAFNQLNSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6X0</accession>
    <name>F9W6X0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000943">
        <property type="protein sequence ID" value="CCD12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37480"/>
    <dbReference type="OrthoDB" id="1717123at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23063" checksum="967EE69F2EE6E442" modified="2011-10-19" version="1">MRSKKCGEGALEHSVRLSSERGLFLPQVDVIVSIFSYTILLFFFLFLVLISGFVFFPHYYYYYYYYYYYTTSVVNRTAEGVSLPAIIFALFYFPVFVPVFSRSYSYIVLTGFLIVYTHTLTNEGYDISGNSCCHPRQCSVFVVVPSCGWCACVAGSLMGNRCNHTLHRPFSSPLVLSTHTVHPPSRFLYSLFLSHPFPPGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W794</accession>
    <name>F9W794_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001001">
        <property type="protein sequence ID" value="CCD13059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1248226at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15636" checksum="831AAF5C725D70A9" modified="2011-10-19" version="1">MLNALASRKAAPAQAAEHDKEWSNSTAIAGVLRQSIMRDALLLAERILASSESMQKIHTKFSLARVLQRCAVCGDDPREAMQKPSIGGLGGPKQAPRIVKLHADATGLESGTSGAQAGEQRVLLEMQRSKDRTQGLPYLYRCPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B1</accession>
    <name>F9W7B1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04030"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20051" checksum="95689825D3017751" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKGLGNPEKINLYCFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7G2</accession>
    <name>F9W7G2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001026">
        <property type="protein sequence ID" value="CCD13128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39100"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="OrthoDB" id="1458984at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="321" mass="34229" checksum="40A711042355ACB9" modified="2011-10-19" version="1">MSNSYTDYSHDHMFLGKSHEENAKRTLWVVALTVVMMVAEITAGYLTGSMALLADGFHMATHAGALGIAAAAYGYAKRHASNARYSFGTGKVGDLGGFASALILGLVSLGIAGESLFRLFQPTQVQFGTATLIAIVGLAVNVVSALLLSGGHNHHHGHDHGQDESHHAHGHDNNLRSAYIHVIADALTSVLAIAALLAGRYLGWVWLDPAMGIVGAVVIARWAWSLMRVTASVLLDQTDDHVAEEIRELVERQGDASIIDLHVWQVGPQARAAIVSVLGSPAVNAQNIRERLATVHEITHLTVEYRTKPGAVSPDQVAVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7G9</accession>
    <name>F9W7G9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001031">
        <property type="protein sequence ID" value="CCD13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00350"/>
    <dbReference type="OMA" id="HIFREQF"/>
    <dbReference type="OrthoDB" id="1300278at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="PTHR12378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="2">
        <location>
            <begin position="44"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="25878" checksum="1BE753055F826255" modified="2011-10-19" version="1">MAGAPKGGSLLEFANKARDALSDVLSGLGPEGTRRSAPADLPSSTVFLNVYDIVRSNNVLYYVGMGVHHTGVEVYGMEFAFGRCAGDTGVVQVEPKNTPPHTFREQLVLGTTKLTRGEVVALLQEFKGNREQWSGYSYHLVRNNCNHFSGAFAKRLLPPDVRFETYQEMMMGNGSNDVVEIYDNGERETVQLSNGNSVTVPVLMPSWVNRLASSAEGILGSKLVDSLDDMDKRAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q7</accession>
    <name>F9W7Q7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_39990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001065">
        <property type="protein sequence ID" value="CCD13229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39990"/>
    <dbReference type="OrthoDB" id="1672016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389916" evidence="5">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="87"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="353" mass="39224" checksum="97E26105D6D9ECA8" modified="2011-10-19" version="1">MEIWVLKTVMVVMVVMGIHAVGEEIVLNTSHFGALCNITKAATKLWSAANGQAHFFDKMEKITQIIDGIFFGLNCEASSGGIWNFPQNFIGTNPKRSAICGSKDTSAHMPSASDSLASTILCLCTPTTEDKKELCGYPVDGHGKWSDSESEDVEELFKKVWGDWEDGMFVKNCIHYDTYGDFEGARKNLTAEVESLKITLEDEKGVILGQKRTTCGVSDVCANVNRNPAWLEKLEILIENTKITIPLMVIQEAPREKMPKSESTDTLLPIHEPTNINTHTSPTAREDHKKQESPKYPENQPEAKAQPEPDPARKATEIPRKREEDINPVSEANETSGCLLTSKKWLFLSLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7R4</accession>
    <name>F9W7R4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1645</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001070">
        <property type="protein sequence ID" value="CCD13236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40050"/>
    <dbReference type="OrthoDB" id="1691243at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="234" mass="25618" checksum="C0AEF7101286A0E6" modified="2011-10-19" version="1">MLAISAQTLVYQRILRESGFGARSRPRVRNHKHCRSETGSKIESVSVKWRAPKKSKAYEGSQVSVCSCAYKAQWKEEMGNLTPTIRKCDQVTNIIVNAITTSGNYVCSHPNILNALEYGHPLEDIVVRVKTAGEKGAAIRSLVCDSELGNLNGNLISESNGGNGVLENSTGGVELRALEEDVDIGLDVDNPPNNARVSALGAWSLVAPVPFPVVFIEVLIFRLVRRWSQGDTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y1</accession>
    <name>F9W7Y1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1674</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001102">
        <property type="protein sequence ID" value="CCD13303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40700"/>
    <dbReference type="OrthoDB" id="1407825at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="381" mass="42893" checksum="6615CE1AD73D5AEC" modified="2011-10-19" version="1">MTSKCDGSYVLKETILAEAPKHTRRKRTTKSCHSQVFDIICDDHADEIVEEDITRDSEKHAEAAQQENVRMHTEEILSRKKRRKQRCNRSVSFLFDSIGDEGGSAVLRESATLCGKKKIRSTRRQPRKTNERSVTFTHIEEMERACEVSEALDNTGFDPPSETVSPAKHTRMKSLRRSSSPRGGNPNFTIVEVPEDHVETIIEGDFGIMNLTSRIHSELNGSYQRNGEQNMPLPHIHKDTKDKLCGPITTPQDTVRSSNKLRKRRKEDLHKSRQLECSFVQDEIMVEIQELDNESMQLKHCSSHIPKESNVNMGGDVMADSMTLNTIGSSILPDIPSMNSPKHGLRHKRTTAHVVNVTKLPEVLASEVPDVVADSMCSTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8C9</accession>
    <name>F9W8C9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1728</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_42100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001162">
        <property type="protein sequence ID" value="CCD13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42100"/>
    <dbReference type="OMA" id="TPPCEKQ"/>
    <dbReference type="OrthoDB" id="1275249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="302" mass="32135" checksum="8E59EB3EA1E25CD1" modified="2011-10-19" version="1">MLRRLNLHTASCIAARHRVALPSTLIVGRKFHLQNQQERGISIGQPSPLCESVRRLHSQPAQLMRVAGGIKPQTSPMNFTGSSDGSGSTADSLTPYVREHLMKVYGLLAAGCVAAGFGSVLMFATPLCKTIPFWLPMAAGFVPLLWLSYAPPQNPTLKMGLFFSFTVLEGMALAPLIASSMVKGVLGTAVVLTGAVFCGFSAGAYLAPRASLLALQGPLFGMLLGMVAISVLNIFYPTAFAHSIILYGGLALFSLMVSVDTQAMIERARCGAGDVVQDAMQMFLNVVNIFVRIAQILGSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8E7</accession>
    <name>F9W8E7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001165">
        <property type="protein sequence ID" value="CCD13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42280"/>
    <dbReference type="OMA" id="YAARTGW"/>
    <dbReference type="OrthoDB" id="814241at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF16575">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CLP1_P" evidence="2">
        <location>
            <begin position="135"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="48961" checksum="3345893E83531021" modified="2011-10-19" version="1">MVIRPTLMSNIDQVSFRLTAGSELVVVVPYETERCFANLKVTSVVGCLDPRVDILGAPGVVDVPYNLVPGVIFTVFAWSNAIVRIEGSKQLIKNCYKSTTHSFTRPIVEYHCLIHNARLLADKQTLFGPMVIVCGRNDAEKHAVARSLVSYATRTGWSPQLVDLDPGVSQMLGSPGTISAGIIEYPLTLDEETTAGPLSVSFFVGSSEAQIKGVSGEVNMYIPYVHYSRLLLSCVSERISRHIGGVSGSSGAIIVLPELRGNSGLLFITDLVRRFNISHVLCIGDDFFFSGLHEKVPKLCDYIGSRDLTDIRIDKLSESFHYQPLDNRPERLSFMIEQYFFGGGAVDIQPSEIRRRYTNITILILKDVDGHIAVSPVEQEALEGIVGCVGALFEASATNEKDTLSLAPFALARVQGIDANGVSLLVSTHSALPERLSMIVGNLRWVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L9</accession>
    <name>F9W8L9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1746</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001182">
        <property type="protein sequence ID" value="CCD13553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42950"/>
    <dbReference type="OrthoDB" id="1672057at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="38142" checksum="C45AFDDF47C5A6CE" modified="2011-10-19" version="1">MILWHGPSSTWTLCSRIRDVLMEDCCGLCDMSLRDFLMPHFGRMVGYLTASMSAFIGSPSIFLKVESLRTLVTSSPPYREFVREYELHKTLREGDYRQRAMGVINIRHCDSAAATTDEVEGVGACVRGVLNVALDIANGIGDAPTDEESDGMYDAVFNAEWRYVARSDEYSRKWLMVSVLGMAPGEQPHLWSGVQADVRPEHKEPWEGDVVPCVKVKLVMAFLSSLKGWPCGLFQRNEVPDVSTLTEYDVTCDAYIRKEYLRVWHIVKEGLDQWMESGRVVLPLIVIGTPGIGKSFATVSLLLYQLLHYTLERLEVVAYVVEGKAYISYREERRVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W949</accession>
    <name>F9W949_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001260">
        <property type="protein sequence ID" value="CCD13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44470"/>
    <dbReference type="OrthoDB" id="59535at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1791"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2023"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2410"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1794"/>
            <end position="1815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2528" mass="271251" checksum="0B4A77621FE8651C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W960</accession>
    <name>F9W960_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1826</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001271">
        <property type="protein sequence ID" value="CCD13750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44570"/>
    <dbReference type="OMA" id="MIVALEF"/>
    <dbReference type="OrthoDB" id="729651at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="646" mass="68774" checksum="0ADFB9D277F41119" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9A5</accession>
    <name>F9W9A5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 184</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001288">
        <property type="protein sequence ID" value="CCD13798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04870"/>
    <dbReference type="OMA" id="GWIPTIF"/>
    <dbReference type="OrthoDB" id="77113at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="328" mass="35974" checksum="342EC7D3767D3A0D" modified="2011-10-19" version="1">MVPEVDPSPSEVPLERLLWKGWIPTIFFEVLPKPRRVVELSPRLIVTLYNHKNEAIYREKLVASPGATVGQSLACTLLRHARMFGQQAVTPPSVEGTVPGSGVGRSSEGHSTNSCGQNALTSRQTPPSSSFGSHYLVLQVDPHECVIRKLFEMPVREDGTLDCDYPLGDMLSESPSTFNGGGVSTAVDPLVLSIVPAAPLPNDHFRLPCCHGEMFLEREGVPPATFGQPFVVTVSNSITVKSAQELLLEFTGLTPSDVLPLSRGVFVFPGRMCASLRLEESILDFMRRELRTMNPQIPSLLLNHRQSGEKHGLRYLAQSSPALRISKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9C0</accession>
    <name>F9W9C0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_45130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001293">
        <property type="protein sequence ID" value="CCD13815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45130"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="56"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="357" mass="39114" checksum="8DC51EABC666326C" modified="2011-10-19" version="1">MEVVEKWLKMRENFFLSVLLSHISVKMAVGHTVGDNTDVRNLLCDALKAGLAVQRSVNGEVNTTLREAIYGNRSRGLFGEGGEVTLPWSCGSGGNGRGVVCDYNGGGGCFVESLLGTFFCSCTPGYRIAGSEELCGVRDWGEGEMWLGWVVGDGTKYLFKKVWNSVIQRCYDGEEIGGDDTNHIKRLGEALQSVENNLRQSESFFYLGGSGNSGCSGVRGNDICARYKKNPRSNKAEIPWVDKFRKAISILEEERTRESSRITTRVASNSNKAVVAKGVTVLNEHTAHDTKGKINESEHSTSRGRTSINSEDKATERTEVSPKTSSNIDIANIENDLKEDGLLITQPLWLPLAALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9D6</accession>
    <name>F9W9D6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 185</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001299">
        <property type="protein sequence ID" value="CCD13836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04880"/>
    <dbReference type="OrthoDB" id="1722788at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18864" checksum="11A4FB4219FD6F56" modified="2011-10-19" version="1">MDWSPNVARSCFSKLPSNMSRDARHLVQIVPRQRDGQWAALSTISLHQFHRKTIRGGRQGRHLAKAGSPRNNSFCHLLLEPGATRPRRGRGGSMEWISLGLGAPEDGDISPFLIAIQTRAKFLGERCRAARTRLPVGLKNASPQISRGSRVSFFSHFSTSSPRRHQRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K8</accession>
    <name>F9W9K8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46000"/>
    <dbReference type="OrthoDB" id="1699179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="26246" checksum="27347A7340079BED" modified="2011-10-19" version="1">MHRSVVSVSTRPALPHRQTCKIRRYVNGSVVGHQDRHTSGEGKKNIHLDGSKQKEKEKRTKEGNGAENAGRAKYIHLTRETSKEENKCARRRTGSKNPLIASWRAPPTHSLTCLPCWLKEEGGRRQRFRRKQSNFKRERRGKKGIAKVVGRRKKERNTKQLRHRPVLELTILCMPLYIYAHKRYLAAYPFMHLDTLAVGAVHTLKYIRQGNLNKNKGKEKKKRIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M1</accession>
    <name>F9W9M1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001324">
        <property type="protein sequence ID" value="CCD13923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14587" checksum="F36A81623F31E990" modified="2011-10-19" version="1">MVCGMASTHSLTCSAISAKHNKRKYHRSSASFPLLGHVQGPLPPHTSECRKAIAFTHWVTHVPLKHTTTHFIPSLPLTHGLTLPSLHWPWRVLRSLQSLPLARLSNYNKREMASRPPVTTAHPLGPMAASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9R3</accession>
    <name>F9W9R3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1888</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_46520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001339">
        <property type="protein sequence ID" value="CCD13968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46520"/>
    <dbReference type="OMA" id="KTSGVNN"/>
    <dbReference type="OrthoDB" id="803033at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071076">
        <property type="term" value="P:RNA 3' uridylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAP-associated" evidence="4">
        <location>
            <begin position="580"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="968" mass="107379" checksum="51B1F13E2A524193" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9V4</accession>
    <name>F9W9V4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001354">
        <property type="protein sequence ID" value="CCD14009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14267" checksum="F0EDF54DB46E35CE" modified="2011-10-19" version="1">MWTRTTWKQKGCIMRRFYAFAGRHELLAGQTTVRLFYHKFAACKEQCNLVHEDTAFHIGCRALASADVLSGFVLIGRWRPHKTGSSRAALGARFRLQHASTRTGWSGVTPGMCSSRHVARDGTATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD3</accession>
    <name>F9WAD3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001415">
        <property type="protein sequence ID" value="CCD14194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48420"/>
    <dbReference type="OMA" id="SRHFFGI"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="66"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="49659" checksum="F226EC91609D4721" modified="2011-10-19" version="1">MSSAAPNPVPAGTEPVELTAVGCKGNDEQRHDTNPTPKPEDSKENVGCFAKAAAFVAATIPPGGIAASAFNIGSTTVGAGIFGLPAASQSSGLVMAMFYLLVIPGMAVFSTYALGVAADRSKVNTYEGVARVLLGKWGAYITALIRVLTSFSGCVAYVISTGDILHATLKNSSASDFLKTTAGNRLLTFIMWLCCMLPLVIPRHIDSLRHASTVAFVLMIYMVAVVVVHSCMNGLPENIKSVSVGRNESAEVVLFNSGNTAIEGLGVFIFAFGFQVTAYEVYMDMKDRSVRKLVIATIIAMTMCFTLYALTALFGYLDFGSKATSSILLMYDPLNEPEVLIGYVGVLVMLFVSYALLGMSCRNALYSLIGWDANTVAFWKHCIAVVSLSVVMLVCGLFIPKINTVLGFAGSISGGILGFIFPALFLMYSGGFTLQKVGPLCYTATYVLLLSGVIAAVFGTGATIYGVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW9</accession>
    <name>F9WAW9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_50100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001492">
        <property type="protein sequence ID" value="CCD14393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50100"/>
    <dbReference type="OrthoDB" id="1665575at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="53"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="110"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="426" mass="47106" checksum="50549DE95E822579" modified="2011-10-19" version="1">MFVSDNIVVCDNNWEGMKLLSCFFLEGLEGMMMKLFMVMMVVMGGWVREWRVMANAAVSVVQGDNVKPFSLLCKIYNVANHPPIKPVNTKEYQKIVDDINALSTAANGKERVNTQSEETKSAQTQLIGVTHEARKLLGEIKKVNPEGEVERARNAFNQVIFGKNGKEDLSQRGLELEPRRMTACGSKEQVGTSAGKNLIVDFFCLCAEYNENSERVAKVCGVSLGSGDGTGWGGTKLYPIATMWNEVKNGCETFSKQGVTSTQGGHFLYREFLDTISEGGKIKVNNSGTVPKHGMLGTAVSHGGNSDFNCNGKASVMRIGSAGVCVFYGNHHQEENIDWLKKFKAGLQLIDKLNTETASWQHQLTTLLNRARDLYEKVKADTQLENEEDTDDSPLAQHPNPDENENADSTTRSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB76</accession>
    <name>F9WB76_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001544">
        <property type="protein sequence ID" value="CCD14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51150"/>
    <dbReference type="OrthoDB" id="1710723at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19067" checksum="8F0D55906F567B4A" modified="2011-10-19" version="1">MEPHLIFPEASLIQSGLPATRQRFGIILARHDFVLFHSNQSGKLKPFQYKTEPLMVSALIPFIAPAAICWCAFTLGCTFRYNVVGSYFPLTSNVLTGACFIHTDSPSKQTDKYPSSSDKCRPYGSHISVPFTRTHPFRYAPHSQLPVKLLPPMDGSAMRLDKWCMALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBE1</accession>
    <name>F9WBE1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001566">
        <property type="protein sequence ID" value="CCD14573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51770"/>
    <dbReference type="OMA" id="REHPNER"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="758" mass="85437" checksum="5BF3B77E770D4D2E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH1</accession>
    <name>F9WBH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52080"/>
    <dbReference type="OMA" id="REIMAFY"/>
    <dbReference type="OrthoDB" id="1663028at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="500" mass="56916" checksum="EC4D3473D4A02574" modified="2011-10-19" version="1">MARRGVRRTRDEMEEEAVAPVVRAETPARDQVTAATVAAVRPVAVRHEVVVRANGRWTLNSSVKEVLLEDCGGLDDVSLHDFLMKYFKRTFGVEDTSMSVFMDDPSVCVSDDAVLRRITNSSPYREFVEEYEMYKTMREGVERLNAREIFSLLQWEGAVAANEVEDINAYVRGKLNAALLSVRRNEETIRVGDAPSVKVIDGAYDSVFNARWSYVVMSGGYGGKWLGMGVLRVGEGEQPHLWSEAQADALYDPKEPWEGDVVPGVKGKLVMAVLSSQKGWPYMLFSADEVQKRRVDSLTGYNAVCDAYIRRENLRVWHIVKENIDKWNSGVEDVHPFVVIGTPGIGKSFATGSLLLYQLLHHLPERLKVVAYFVSGKAYIFHREERRVVYYVYEETAIREIEEMASKGVKGYMIYDVSGKIVDVRVGSCSSSWGIILITSPDVRKYHEFTKQLHRTLPIYINCYEDVEFKAVLVWERQSQLAKKQKRLKQVKLANDWKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBX8</accession>
    <name>F9WBX8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001640">
        <property type="protein sequence ID" value="CCD14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53530"/>
    <dbReference type="OMA" id="VMEANEY"/>
    <dbReference type="OrthoDB" id="809861at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="1">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="25257" checksum="B1AC40A61574CBAC" modified="2011-10-19" version="1">MSGLEKCEKLLHKKVPEMGSKIYYKANIIYLDAEDVALLKEGEEVTLMDWGNAYIKNIRSSGVPAVITDADIELHLDGDVKKTKHKLTWVAENQDAEVMEANEYDHLLTKKKPDPEEHLENILAPVTKYTQEVYAEEAVNTLRKGDIIQLERRGYYIVDSVVPRKVLIAIPDGREKINHLSAKAHYMKYVAKQSHTTAADDLAAKRAAKAAKKAAQKQNSKQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC82</accession>
    <name>F9WC82_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_54480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001681">
        <property type="protein sequence ID" value="CCD14874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54480"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394671" evidence="6">
        <location>
            <begin position="22"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="49"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="44612" checksum="3A6A0009CCB58682" modified="2011-10-19" version="1">MFKSMKVMLVIFEMLVEFGNSSSVDNNGQEKGLLCDVLGFTQKVMSHMDSSLAKELKEAIYGSSRENYLFGEDGRLTAGASECGYEKMRIQLCIDNNEFSLGLGKDRCYAKSLVGTFYCLCVPGGRVERIGTLCGIKVSDYSGRGWLGSGSISPNTEGLFKDVWDNIIQKCTHEKENRKDYTEEVKLLEKSVDDVRSKIEGKKGDNNLYYLGGSGATLVVERVRTMSVRHIKEMGERENIPWAGKIEKALEKLKQTKNQSAIVKEAKRPSKKGTAELSQAPERLEGHTTLTVHETGDKANEDEEKTQKGWRKEKFRMETDQLKTKNHQSRQTAENTHLTSDHNEDGSHVTKQKWLTLAVFLNDNKILPQNNYSGNNNLNHTSCAFCEIIFLFSFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCA9</accession>
    <name>F9WCA9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2208</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001694">
        <property type="protein sequence ID" value="CCD14902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54720"/>
    <dbReference type="OMA" id="TITHESE"/>
    <dbReference type="OrthoDB" id="947320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028648">
        <property type="entry name" value="Vps5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="PTHR10555:SF170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="SSF64268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="486" mass="54707" checksum="7609BD537E961665" modified="2011-10-19" version="1">MSEDSTGHRLEFFVAGAERVFLENDNTLAFSHWSYKVLTRSFLESYQNPPILPCSEVQNNFIKGDGYIDYCTWHRYSDFQWLAAEVSKELPGIIFPPIPEKDINGTIDKLTAHFVGSDGLDASTNELVSQRSRRLQMTLNALAQTDIAHESQAVMAFTTLEEVEWHKFRESRECADKPSFFSSIRESCSDFLERLGVSGGARDAGHSISARLDSIMERHEKMVDIIKKCSDAVDRMSKSCLMDLPKRKKLANISKPLQKCDLPATACCIGSVVECSSPRGRIGVVKDMDGEKALVEWVGHEGEVSHVELCKLKYPETGVSDPVIIALHLLTQQIDTHLEETKTKVETEGIRDVLDSLWFICRYSVRCISTVKQIKKMESNMISFIQGSVSEVGNRDGAQIESMKKNLSDAYARFVEQYEKVYCPIQTKLLVGLVQKLGYSAAVLLSDDKWHKQIEQAYSALSLLEDETLEKSTELDFSVRNASLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ9</accession>
    <name>F9WCJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_55600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001731">
        <property type="protein sequence ID" value="CCD14993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1712841at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="21913" checksum="26BE11A55CE5674A" modified="2011-10-19" version="1" fragment="single">MKSGDVPSTRKRSRETGFSADAAIPCDEQPTGEQAEGRSTTAHGAQHAVVYVLSDEKASSVDDLSPPSTGNDTVITKGNSPGGTASGERKLKQVTLPSYGMVSDLSVFRKEIADRDAQIDELREKLAAAEVRLTERESTLLSVESQLEEAITCVERYQCVLREEMTRAARQSRSDARRALHMMHFENGQAGFLQNNNRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCN3</accession>
    <name>F9WCN3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001742">
        <property type="protein sequence ID" value="CCD15028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55940"/>
    <dbReference type="OMA" id="CADGINH"/>
    <dbReference type="OrthoDB" id="1099332at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="PTHR14927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22094" checksum="9F101C07A36E3AA0" modified="2011-10-19" version="1" fragment="single">MQVSLHNKVKTYNLTAGKSLPEWIAERRKNKRLAGGEHRIELIHDLEFPHFARTIFRTANGTHLFAAGDYPPRLKCFDVNQLSMKYSFNADMPVLSGVSLSPDFRKFALRGEGRQITVHHSAAIIDRVRVPHTMRSLAFHPHTAELLSSGTSHEIFRLSLETGAFVESYKTQCADGINHVEVFKDHGLVMCAGVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCW0</accession>
    <name>F9WCW0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001778">
        <property type="protein sequence ID" value="CCD15108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="PCENENK"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388989" evidence="2">
        <location>
            <begin position="30"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="712" mass="75552" checksum="E72D46D963360327" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCX0</accession>
    <name>F9WCX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2287</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001783">
        <property type="protein sequence ID" value="CCD15118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56780"/>
    <dbReference type="OMA" id="PGYMTQA"/>
    <dbReference type="OrthoDB" id="1204225at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="PTHR12406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36125" checksum="BBC6D9E394C19D70" modified="2011-10-19" version="1">MAPTDPREWIKKVRSKAPTLLEVGKPSPKAVLSFGGCGFLVTYSLGVALYLQQEKADLLSQSFLLGAGTGVIPAVALACGPRAVNIEKVRDAILDNRFIVTDDEKRIEVFTKYINQLLPRNAVELVSGRLALTIGFSNRDPGYMKQTKEQIHFGHHIAHWTDVSDLSQCILAATAPNTAKPMIFRDADNVMRGTMMSLSSELDQYCRHIYIHGYSGYAHNKHQTRHNIFFGRHGFLANTHFPFWKQVLLAFAPNIGGDSRREELLEAYDAGYNDARRYGRWEEDPYYFAKADRSPCDDFSFRQLRANLFGGKKAAERFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC4</accession>
    <name>F9WDC4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001855">
        <property type="protein sequence ID" value="CCD15277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06000"/>
    <dbReference type="OMA" id="YHTMSIE"/>
    <dbReference type="OrthoDB" id="1400644at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="207" mass="24193" checksum="5895C627EC24FA24" modified="2011-10-19" version="1">MLRRRSRNVFASAVTMLRMTNCTARQHATGESTENDAGSCSEGGTQGTSGNGCAETLYRDRLISEILSRDKEIFELKRQHELSMLRVEQNQRRVLKDQEDRGMYYEQNCNVHTFDTVSVGLYTQRNTLYHTMSIERLRNVKLFTTVLVTVLTCFYFYYRYMINDDWVYVQKPMRLLGSRVGALAELREQMEEEQLGRESQRGLQRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDI5</accession>
    <name>F9WDI5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001874">
        <property type="protein sequence ID" value="CCD15339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16177" checksum="F7950E975731493D" modified="2011-10-19" version="1">MRLYLCEGSNQNKQGGCAPKEYYASGSFRSLSSTAGRGINDAHNFDREQQPRMYVARRELSPVAATSRTPLMRRRRKKKKIREKASDRGVKGPGKQMAKKREERNIGVSFFFFSFRLSCGKRRSRPSALSTKRVGVQVLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ7</accession>
    <name>F9WDJ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 2372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_58780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001878">
        <property type="protein sequence ID" value="CCD15351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58780"/>
    <dbReference type="OrthoDB" id="674800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48955" checksum="9701D37AE312A18A" modified="2011-10-19" version="1">MALGLSSSAEVYVYVTCLFLGVSIILPLNTRYSAPMFMINYYKYVTGDENAKPNSVLFWANILTFYTVISLVTQSFVGPTVLTQTVRRLSLSLRFALSITLMMTEVFMVLMLPITKVSQTTAIVFFVIATILGGMGKPCLEATSYTLAASMPEKFTSTIMFGISICGLLTSMMQCIVKLSMENIYESQLTQSYIYFSLALLIMAVALVMALSLRYNSYAQEHVAEFRALKQKHDDNKVEPQTAADVPTEMKETTDVEDKSDVDSRGEGGMTTAEQLVATPIMPVVRIIRMMLISCFLGFFLTIFIFPSLIIPIDRADDWFSTIAALIFNIGNSIGSFSTSFETFRYPRRVVLYVSIVRFLLIIPFILSIYKHIPGHTVPYIFSFILGLTHYFPVLSMVYGPVTHGLNDGQKLMAGRLMGMALLLGASAASVVAMTVVIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ2</accession>
    <name>F9WDQ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2388</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001895">
        <property type="protein sequence ID" value="CCD15406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59330"/>
    <dbReference type="OrthoDB" id="427965at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="284" mass="30274" checksum="193270A535339DAB" modified="2011-10-19" version="1" fragment="single">MSNHVVFGRPMVVTEEKLNEAMKKQMKQRELREALDKQIAQARKLKDEALAGMRNVNKVTYATRDQPNGYGYGNDPHAVARHNKMNNDITDSTTTPRRNAQEDLRGNGVATLLPLCPSTSLPPNFAMSTSEGNPLAPPNVYNTNSTSANVVTRLARGGNVASTALASPRGKEPLPLGGSPQRNHPVANSPGTVCSNSPPRGGVADDAKTKVQVQKQHSPRKSVKSKVSSGLVAGKAPVSGGRRQFSQSPKRPGGLLPPLEVVDGISSRHPSEGTVLSGRNIETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ4</accession>
    <name>F9WDQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2389</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001896">
        <property type="protein sequence ID" value="CCD15408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59350"/>
    <dbReference type="OrthoDB" id="1691804at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394694" evidence="1">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24870" checksum="C7D3B29C2A492EA4" modified="2011-10-19" version="1">MGTPQHVSVMTMLPPLWLMCVLWGFATVTGEDCKDNVTVHVYNLLYSKKIPPSIYVPLIAGFNASVHAGRKKLPAGVNLTLLHPPSLELGVTPEWLSGKVEDLSQRDIPIVVGPAGTSVIPTFLPVLNEHNAVAFSPFTGSSTLRVWNKNLYFITASPTAELLALLRYAVTQLRLERLGFMYLQGISFGDEEYRLTVNALSNIGRGLCGLFTVKSSIAGAAPDAELFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDU8</accession>
    <name>F9WDU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_59720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001916">
        <property type="protein sequence ID" value="CCD15452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59720"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390228" evidence="5">
        <location>
            <begin position="20"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="38555" checksum="EAD8D50B0BB5B657" modified="2011-10-19" version="1">MFFVLVGMLMMGLSGNSLSTGISEHHNHNEDNHDTLCSVLKAAVTLYHSPPSGEKLKKALAQAIFGNQTGGKLEDLKKGLAHEYKTPGSRESSCGSCTYSDRKHYPGWSIPHDLICMCTVGEHGYPFGQNSDDHGNPTLCGRSAADFGCGKNPKDGSGCHENNKHWWTHSSNHDWSGTGQVREHLTATWEKVVKPCLQRRNNGQTKKTLLEKLKVEEQQSPKWARGHTLCNGFSGAVCVNYGHHCGTEHNNNSPQWWKELYEALTTMEDTRAQRNSTRFPRRRTLRKPGGTLTPEEPEDDSEEDEPEETGSTSTSNNNLPLTLLSNQQSGTHLIPPHSWFLTAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE50</accession>
    <name>F9WE50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2439</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001952">
        <property type="protein sequence ID" value="CCD15556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60480"/>
    <dbReference type="OrthoDB" id="1728304at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17471" checksum="B9A6EA5E3CE45724" modified="2011-10-19" version="1">MFLKTRLLARRGAEFTRPQHIVWQAARPLSTNYLSNYGDSIWEIQQKRNSMQGRWNISYLRCALMVTVSNGEPICCLSIVKCCLPPAAQCPTTLFFLFMPPFVLPQGGRGNSVLCFLATFESFPLVQGASGPRRLDRALNLPKGTVCDSVHPAPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEB7</accession>
    <name>F9WEB7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_61070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001969">
        <property type="protein sequence ID" value="CCD15624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61070"/>
    <dbReference type="OMA" id="IAVNARC"/>
    <dbReference type="OrthoDB" id="1661548at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="49766" checksum="07A6852CB1911A5F" modified="2011-10-19" version="1">MARKRGRRTRDEMEGEAAAPVVQPPARGEMTTATDTAVRHAAVSHEVVSRPSSTWTLDSVVEDVLMEGSGTLDDMSLHDFLMEHFGGTFGFPSVSMRVFMDDPSLCVSDEGVLRWITNSSPYREYEAMGEGVDRLSAKGIYFLHQWARADAANEVRDITLRVKGMLNAALYRVRRNEEAMRYVYAHSVKELDGVYDSVFNARWSYVVRSDEYDGKWLGMGVVDVAPGEQPQLWSKEQADVEPVVWDPWDGDEVPGVSGKLVMAVLSSQRGWLYGFFQRDDVPKAPTLTGYDAACDAYIRRENVRVWHIVEKNIDAWNSGVGYVHPFIVIGTPGIGNSFATGSLLLYQLLHHPSEKPKVVAYFVRGEAYLFHREERRVVYHLGKKTTIYGIEDMISSGVEGYIIYDMCVGHNSIDSLPDEWGAVLFTYSKDNSDWWSEDRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEC5</accession>
    <name>F9WEC5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 247</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001988">
        <property type="protein sequence ID" value="CCD15632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06510"/>
    <dbReference type="OrthoDB" id="1724334at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="19029" checksum="54A3E4429B6FC758" modified="2011-10-19" version="1">MGPPELAAAARPNATNISAGQVLFRVASCVDGLNKSSGDSCSRLISNVTKTASSFGGANFSNSSSHSGAPGSNADAAPTPSAVGGSRGIPAFVALFVWVCLLALVIFSLCRILCQCFGSNETSRTEYNEILGDYSPAGQATMVAVDAGAPVGCGKACAVGNASRRQFRDSRQRAARSAYGTDNPATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEL7</accession>
    <name>F9WEL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002034">
        <property type="protein sequence ID" value="CCD15728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16738" checksum="AD6743DAB2F53111" modified="2011-10-19" version="1">MCAMLYGNTFPICCGNLDCLPLHSSNILGPHRLGRSGTGIHGKFTMIMTTCLWKPSTRRSGVGVGGHHHPHTNPARVSLWSKRRRLSYKCRIPPWGTSLIYLLPPDHGLGYRICQFYSNHPVVFEKTFIAQNAFILIFFWEGRRNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN9</accession>
    <name>F9WEN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_07610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002043">
        <property type="protein sequence ID" value="CCD15750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07610"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="38267" checksum="8D4C4B1001F1FE19" modified="2011-10-19" version="1">MFVDTGEEEERLKEELHELRKECIVWKDMANFKKELTQESAREQRVHEGHAVDLGLVMESCAEFLELVAKVVEPLEPKGSDAERLKTSIMLEKLKKGLTKWPEYFETKKNCWQKRLEVEEEVMENDAVEKELKEQEKQVDELEKELETIEEKIKKDIVPMQQSDPEQHPCPYCDRIYASAKWLKRHVREDHPGQPTTGIDEDRVSFECPHGCGKTYQTRGWLMRHLQDKHGERPQSDEAADSNPIYCPHCDKKYASVGWLRRHVQKDHEGETDPDIGACGMRVPCPFCDRKYASFVSLKKRLKDKQENEAITGSDEGSVRLSCPHCKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF00</accession>
    <name>F9WF00_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002084">
        <property type="protein sequence ID" value="CCD15866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00990"/>
    <dbReference type="OrthoDB" id="1742787at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="20244" checksum="0FCF1E315C40E6A1" modified="2011-10-19" version="1">MLRLMLQKQRKKKKSGGLPSKRRSRRNVFRFFLLFFAFGFAVVAHNKKKNPGAFPTWMCRVTLMGQFKLFTCWAIFGPTRICNFHIDYLSSRVQNVLQMKVAPFCFSHFLWIISLIVIIILFRSPSPPTRTQTHPRHVTVLRPVGLRCDRVEDKVRPNKHENTGDARGREISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF39</accession>
    <name>F9WF39_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 345</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002098">
        <property type="protein sequence ID" value="CCD15907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08990"/>
    <dbReference type="OMA" id="HAISCAW"/>
    <dbReference type="OrthoDB" id="981799at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="10"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="45276" checksum="D19DF4A1C18DF87B" modified="2011-10-19" version="1">MSTGGESKDTSLETTSVRHIDGRRGRGLVAEVDFDPDSTILCVQYDIAVLYSPFVRNTCYRCFESVPKASKSHGQKRSSRRSPTRQSSKVASKRTQPRQKQTHIANSEQKAGDEHYECNACQNLVLCEDCVRDLVAVVQRQSASSGSPVAGEPCSPEERLRLLESHPLLQVHKQACAWYCSLPETMRDGDTDYLRFALQYGARALLGDTSLLLSVEELCTNATQQSPESREFCASFARRVVDTFAPQGFRVDADHLRDVLLRTKCNSIGYPFDDEQTLGWLLQEKLCMINHSCDPNAAIVRPRQSTLTSSAGHSACSVELIARRKIKAGEEITIAYIDVDSYGEDHQARRRHLLESYWFLCMCNRCETSAGTTAPSPSPPPPEAAHKKSSLAKNKNKRRKNGRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFD8</accession>
    <name>F9WFD8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002132">
        <property type="protein sequence ID" value="CCD16006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09770"/>
    <dbReference type="OrthoDB" id="1643824at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="334"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="413" mass="48252" checksum="B3CCE2BFE55AB84D" modified="2011-10-19" version="1">MDGKDDTEKVREMLEEICRVIVIQELFKNDPDLSADENALQHYAVLLKWEEHIQEKEDLDEESKRKAMIGFCQRMPLHLVFLQKPEYRRLKYVVMLQILLLMEVPSYSDRKWFYGLLARLLCSFIEPLREVNDQSDSDSSEGGSLFINTLMRFVEPDFGPDIQEMFKNNPDLSADENARQHYMKLRGWEERVQEKEDLDEESKRKAMIGFYQRMLLHLLFLQKPEYRRLKCVVRFQNQLLMEVPSYSDRKWFYGLLARLLYSSTDPNTPDDSEDDASDDSEDDASEDDASDDSEDDASEDDASDDSEDDASQDEDKEESESSPQSALRRARAAYEKTVKKLSKVEALKKDAEEQRASERYMERLSAKIAQLTEQKDRQVTTVDELETDLALERILQTTVASKTENSQVQFMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFE1</accession>
    <name>F9WFE1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002132">
        <property type="protein sequence ID" value="CCD16009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09800"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18126" checksum="4D74DFCFC3CA6964" modified="2011-10-19" version="1">MDSLNKQLNCILGFQHGNFADDLTIVCTSADLSAIQQTIQHGFDCIMRWSEDHYMEVSAEKTGYTLFAARETNLLSLKVGEAVLKKVRTPKLLGLTMQPHKGLSKHVEGAKAVADARLLQLRAVVSPEWGPEREKLRAFYRALVQAKVCYGMASWWFVISAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG6</accession>
    <name>F9WFG6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002142">
        <property type="protein sequence ID" value="CCD16036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10040"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389058" evidence="1">
        <location>
            <begin position="24"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17747" checksum="627D5B3B3B85547A" modified="2011-10-19" version="1">MMIMKLMFWMMMVVMGVATGADGDKGSDHDAGSHRRLCDLLQAAIKKWEVVKNENKEGPLHKALEKTIFGKEGGGKELEKLRRGLPEDYHTGANGQRANWCGKLYSSEERVVLVRWPGHSAPHDLMCLCTRGENLWLTTTQRSGTDTLCGQDAKTLEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFI2</accession>
    <name>F9WFI2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002148">
        <property type="protein sequence ID" value="CCD16054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10220"/>
    <dbReference type="OMA" id="VVPKPRW"/>
    <dbReference type="OrthoDB" id="1243765at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="19329" checksum="B6DE20FF22E11F54" modified="2011-10-19" version="1">MSGAFGRGSYRSVVAGTQNDLRRATFYPCAYELIQLHKAHKEVIRHFYVRDKVFDNKFPGTALANGLFKFVPNRRESYHMRELMESIRRRSIWMHRIKQQREINAKALAMLEQQHGEGFAADAISFTTPDSDAYFAPQRYQDVANSWPNYWQHPSVRHVVPKPTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFY4</accession>
    <name>F9WFY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 437</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002200">
        <property type="protein sequence ID" value="CCD16214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11620"/>
    <dbReference type="OrthoDB" id="1737530at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="17774" checksum="D8A48B20FD0A730B" modified="2011-10-19" version="1">MRRRIACPLRVAKFQCPVPVVVCTRCIGWRAARYAKPSALVACGTVKEPLPSLHHVALPSAFQQALATLSGSLCTKIPPIDVLLSKREPGAGGAGSSNGNKGGGKEGDERSIFPDSSPEDDGSDELLVARSVLFLIEIFGTSFVLYRLSHPSGKQTGWASLIKTLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG19</accession>
    <name>F9WG19_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 452</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002216">
        <property type="protein sequence ID" value="CCD16249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11970"/>
    <dbReference type="OMA" id="EVAQYVV"/>
    <dbReference type="OrthoDB" id="1571992at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390323" evidence="1">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20175" checksum="73452C5E3A485929" modified="2011-10-19" version="1">MTGRGNKPTQAAATTKLLWLFLFLCGSTPAIADGTGPLSLAGSVATLPEVHRFVEVQVIDGVTGAVVGSMPLDATLTFTFHAVPKTVSEVRLFPRLPLHRFRLNTSASVLRTPVRAEDGGSGWLHLSAVVEELKELSSHDQTEGNLATAATAMVVVALIAIGRYRLLSLFQLPAFRPPKPQKIAVAVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG21</accession>
    <name>F9WG21_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="3">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Signal peptidase complex catalytic subunit sec11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_11990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01002217">
        <property type="protein sequence ID" value="CCD16251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11990"/>
    <dbReference type="OMA" id="PYIGMLT"/>
    <dbReference type="OrthoDB" id="1486616at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="9">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="207" mass="23642" checksum="86CC6373117EFF21" modified="2011-10-19" version="1">MTSVTQRVDAVAMRMLRSQHLEKLNSASNPVNYVKSVVKNFIDTLPDKRNTFFMLLTLCTFFVGWRTAIAMTGCESPLVVVLSGSMEPFMFRGDLLVLHNIGEPRMGDVVVFSLPNRSIPIVHRVHRIRLLEDGETRLYLTKGDNNEMDDRTLYPKGYRWVEKKDIIGKVSVLVPRVGYITLIAEDHAWAKLVLVPLALIWCWYSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB1</accession>
    <name>F9WGB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002250">
        <property type="protein sequence ID" value="CCD16345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12840"/>
    <dbReference type="OrthoDB" id="459185at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="92"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="25792" checksum="79D131F602568BC9" modified="2011-10-19" version="1">MPYFVVDECPVTKRSCELTVEALSSHMNGTETVVKAVHCSKHYGAALLSNGRLVLLAQGSPKYHGSIVEHGADNVNDVAAGDTHIVFCKSDGTVYSFGYSNTYGQLGDGTVWASCTREDEPGGDGPPVLSSPQMIRGFGRGKLNIDEGDVVEGKRVCVPIASVACGSHHTLLLTRHGNAVYCCGHGLDGQLGGKRRPALQPSFKSIRLLFGLPIRQVAAAGKHSFVLLQTGSCLPLETTPAGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD8</accession>
    <name>F9WGD8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01480"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390337" evidence="1">
        <location>
            <begin position="24"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18218" checksum="559364B3B15CC0D4" modified="2011-10-19" version="1">MMLMKLWMVVLVVVLTTLVRASGHNEAQHDALCGVLKKAVSRWGKEGETLTEPLKTGLKVTIFGNESGGDIEKLRKELPEFYDNVWSGVSASGMPCAGYYSGRSAPHGLVCLCTVGTDGFPFHGRIENQKLCAQFKDALGGGANGWGRSLVVLDDSSEVSQNEKGETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH1</accession>
    <name>F9WGH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002271">
        <property type="protein sequence ID" value="CCD16407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="74004at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="112" mass="12383" checksum="FF07D5682473228E" modified="2011-10-19" version="1" fragment="single">MPSYSGGHPQTLEEVINTVLVTGEPAVVIPSCFLGELDAIVDEAKSRGMKLANVPKGGVTILPPIPVTDSELLNLCLSYCRFRTEENILRCLVVWIWTNFWKNPRALLYPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH6</accession>
    <name>F9WGH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_13360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002272">
        <property type="protein sequence ID" value="CCD16412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="288077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15337" checksum="5B510CAA96EFCE78" modified="2011-10-19" version="1">MDKSSGKKEEITITNDKGRLSEEEIERMVREAAEFEDEDRKVRERVEARNSLESAAYSLRNQVNDKDKLGGKLSADDKAAVEAAVKEAIRFLDENPNAEKEEYKTALDTMQSVTNPIVQKAYQSAGAGDKPQPMDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGR5</accession>
    <name>F9WGR5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002308">
        <property type="protein sequence ID" value="CCD16502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01640"/>
    <dbReference type="OrthoDB" id="12773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="591" mass="65681" checksum="ED85C7B8B99D7D80" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH98</accession>
    <name>F9WH98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 617</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002400">
        <property type="protein sequence ID" value="CCD16687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15940"/>
    <dbReference type="OrthoDB" id="1678996at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="294" mass="31704" checksum="7583F89D093DE375" modified="2011-10-19" version="1">MVSSNGGAYPQECLPKQQQQRQSLNTILQTVNFPPRLKYRPSVALPRKHDVIRFIVRRASSVGLYVKRNRDSLRNLSALGVTLVRAALQAAYRSSRIAIFTPSSGAGTECFATCAEDDGEGSSSAMDDTIAGGVLSGLAEFAEPSLFMGILSAFLAYGIDFQKARREALCPCQEKPEWMDANGTLLLECLNSCLPPLDNALWCLHGVANKILLLAAGKISKFRQLPVVDGNVDGLLGTPCPVTGEERSGCSAPSEAESIYLLLQRAYSILALLHVLPLSEVLSADGTPFFLKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA1</accession>
    <name>F9WHA1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002401">
        <property type="protein sequence ID" value="CCD16690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17123" checksum="7DF4FF608D1140BA" modified="2011-10-19" version="1">MEKDTLNSPRTRPVTMESTVEAILERARKDSGAIQAWSFFSTYYKETYGMRRYPSVTLQQFLENPELYMPDAKTLQHIQLNLKLKRALMQKHFQRDLAKLHEAKVVLLKDWSSYKEAVEIGPMTRTVLSGALIQALLQSPGSSLYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC7</accession>
    <name>F9WHC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002413">
        <property type="protein sequence ID" value="CCD16719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16250"/>
    <dbReference type="OMA" id="QYYGRIH"/>
    <dbReference type="OrthoDB" id="939343at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="30281" checksum="22257C1C90818CAF" modified="2011-10-19" version="1">MFSGSFCLLSRRFRYNTKFPALVSYNKLPWEVIHHETPQFHMHVAPHYEQVLTLSAKAHVPHIVSDKHVEVPEGHRLRLLPGLLYVMNGDSMPTGFSVNRVLDPTALQYYGGLSSKIARVDAVRMLVSEDLRLLCNCVTFRSPAHLTIAPHAALASVQSLSTATASGGGAIDGCFTLYHFVRPNRPPRELQLEKYYVHAPCAALLSEFASSNSRNNSWEPRLQSPRRTARVTALPAYRPPQSYLMGLAERLAVVPGSCFGRRSLMWGHWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD3</accession>
    <name>F9WHD3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002415">
        <property type="protein sequence ID" value="CCD16725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16310"/>
    <dbReference type="OrthoDB" id="1712339at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20674" checksum="F23B164D4D26D185" modified="2011-10-19" version="1">MFTLAKRITKEKKAKKPKSGPNMPFVKLRGSHANTVTSCRGRKAGPVIKVTGGSGSKGWHKLLSTFPRNPSRGRPVANNKMYETRWRKYCTGAWQRNFNCVYRCERWRWRWMTNVRNQMAKQIITQNYSHDLLTISNNVPALFTCLSGIYVRRLSGHATERHKHNKRFALCTLTRGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHU2</accession>
    <name>F9WHU2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TCIL3000_0_17700</name>
        <name evidence="12" type="ORF">TCIL3000_1_750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL3000</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="HE575314">
        <property type="protein sequence ID" value="CCC89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_1_750"/>
    <dbReference type="OMA" id="FKPGTEW"/>
    <dbReference type="OrthoDB" id="810128at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="25"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="337"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCC89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD16887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="591" mass="65770" checksum="092EDD0419E779C2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHX0</accession>
    <name>F9WHX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 700</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_17980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002492">
        <property type="protein sequence ID" value="CCD16915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17980"/>
    <dbReference type="OrthoDB" id="1663555at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="455" mass="50566" checksum="0B065BAFA5E31A08" modified="2011-10-19" version="1">MDRKKVVDYPAGTEFDICSWDLTDNSYCITLGRVKDSGDMCDSGVAWGSLGTGAMVAIIACGLLLLIILVLLLICLLRRCCCGRAKEPDGQLVVRRKMDVSSVNLSDITETSGDPSQYGRVNPLLICLNSREESQAVTPHATSPGNGNVANPFTWLGDLSPGTHEFTIDDVERDDRDQIALQEARDRYNMAVAFTEGIERLRVTAKEREIHLDDSGEFNMYEMAVRRGDDGSFRPDIPLAGTSDLLNEIYMRRASQRERAYFRPREEIEVSVMNNMSELSTDNHDTSRLTSCDSMNYTTTQNFYDENAFVSESEAGRRLRMMNWEEEEWQAIVDTEFSDYVRLQQATQSTPLPLPHAVVFPFDAPLPVDEDGENHDTSQDDDLIIYEDGVTSVQVYDAPVVASVVGRTQQSSVPREGSGLHPSTSLFSSPAPVELRRPSRGSGVFNVLSGPSRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHX4</accession>
    <name>F9WHX4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 702</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002494">
        <property type="protein sequence ID" value="CCD16919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18020"/>
    <dbReference type="OrthoDB" id="1680784at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29507" checksum="9AB6577DC40ABB68" modified="2011-10-19" version="1">MDSHSRQVGAVDCGDVGSLMSWVVPEPRVEATWTNFHGHNIVRRPQGTRVASWEEETSLPLQEVYVGTLSLEWVRRRTEDEALRLFDEVWNLMINTGGTSKRDRESHLRIATEDAHKMKQAGVIGHASDLPTKGWAIPSSVVEEKTAGRRRGFIAWPKAKNAKNDYEAEVPPGHISRYLSAVCNEAVALFDLEASFLQADMPRDIREGFRCCTENGELVELKWLPVVYKGDTEIVHTITRALAGGCGGSHNGVRGSKPLENPHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHY5</accession>
    <name>F9WHY5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 706</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_18120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002499">
        <property type="protein sequence ID" value="CCD16930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VHNVYNP"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="5">
        <location>
            <begin position="384"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="854"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="1222"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1193"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1243"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1201"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1289" mass="143448" checksum="A1EEB2AD3F7104BD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI73</accession>
    <name>F9WI73_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_18800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01002536">
        <property type="protein sequence ID" value="CCD17018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18800"/>
    <dbReference type="OMA" id="PLPYRDW"/>
    <dbReference type="OrthoDB" id="826926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017018">
        <property type="term" value="F:myosin phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PTHR12320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="334" mass="35364" checksum="EE055A0DFAE42433" modified="2011-10-19" version="1">MNVSRGLLQPTKSKALLGFSFRAVKWVPHPKRADTGGEDAFMSHLDAQGVFDGVSWWRNHVGVNSGLYSAALARSLHEVIEEVAAPATMSSLDLLQRAYDRSLAKGIPGTSTALVMTLQCSGGGACTSDGGETTEFSNDVLDICNVGDCRAMIIRDGDVVFVSGEQMHSFDYPFQLGESSTDVPSCAQQYHVKVRPGDLLLLGSDGVFDNLFAQKIAELSWACVGPAWAKFVLARGAVCGGGPAAGSHVSPADDVMKALTIALDEVMQAVRTTACDRGCETPYSNKAIEAGIYFRGGRLDDITLLGSVIDERVDSGGALLSSEGASLLPSPRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI83</accession>
    <name>F9WI83_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_02080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002543">
        <property type="protein sequence ID" value="CCD17028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02080"/>
    <dbReference type="OrthoDB" id="1672010at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="15"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36288" checksum="E563DF3803963A92" modified="2011-10-19" version="1">MVDDINALSDAANGKERVNTQSEETKSAQTQLIGVTHEARKLLGEIKKVNPEGEVEKVKYTFNQVIFGKNGKEDLSHEALEVEQKRMTACGGKDKGTSSGKNLVVDFFCLCAKHDDVNEGIDKVCGVSVGKGESVGWGTQLVSPNTMWKEVKDGCKKYAKQSVTSTQDGYSLYHRFMDNVMAGGNVKLNNSGTVPKHGMLGTAVSHGGNSDFNCNGKASVMRIGSAGVCVFYGNHHQEENIDWLKKFKAGLQLIDKLNTETASWQHQLTTLLNRARDLYEKVKADTQLENEENTDDSPLAQHPNPDENENADSTTRSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIM4</accession>
    <name>F9WIM4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002617">
        <property type="protein sequence ID" value="CCD17172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="DEWENQL"/>
    <dbReference type="OrthoDB" id="1655178at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="812" mass="91581" checksum="847C47666DFF9E91" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT0</accession>
    <name>F9WIT0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002634">
        <property type="protein sequence ID" value="CCD17228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20640"/>
    <dbReference type="OMA" id="TSEMSHR"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="45109" checksum="70FCA84FAFF8034A" modified="2011-10-19" version="1">MILWPQEGSEKVRQRFHYRPSLNLYNRIKYVSSVWHNGPALRVDLKASFYQIPLTSEMSHRLAFWAGSREHGGWYAFKRLPMGHTLSPEIMQLAMSSLMCDERFSTIPRALKVCSIDTWLDDARVLAPSEKKLKAISALIQFRMRTCEATIGEWEIAQEYDFIGIHWDHRHHIVSNSDRVIEKIRLLTDSDFWENIMRSPGIPASRIESLLARIIMASGIISIDLFRYHFCIKTIRRRLATLIQTRRDYPIGLHASTVRSLRQWVDRCICNKPRRPMRPCRIASPHTAMYTICTDASTKGWGGIVYDHTMGTISTYGGPWKRKMVARQIAELEAHALWNTWEQWKVTLDLQFRCLCSRKELKPTRDADRTTYSPVHIRFMVDSSVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT9</accession>
    <name>F9WIT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 832</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002638">
        <property type="protein sequence ID" value="CCD17237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20730"/>
    <dbReference type="OMA" id="VENTMAY"/>
    <dbReference type="OrthoDB" id="588600at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="477" mass="53219" checksum="A8B3195EF1CE653A" modified="2011-10-19" version="1" fragment="single">MCDFSNSMFSIVLRSNIGSHSNTRKCLFTMSSHSTDVYVIEDSTASEYSSAVQQISPHDGGGEDVDSSQRISTESCGSEESGEEATARIYVDVGTNTEGLSEPRAKEKVHAAVSELIDTIGQGAIRNDISKRDCNDAGKESRNIIIETQRYVSMQMGMLAKRPLPPVEEERTPRQTHECSQGNEPEWLCDIQAAIERVHDTFLEFGQREVDIPMRNSSPTVAQLSPAVETSRTFLPCDNVAVATHRVDENESIQQLRSEIQTLQEGMAEVHMIMCKEGVSSILPLYNELLSLREMARKEIVKDAVAVRSLLMMQEDHFRQQLGAAQKGMAYISRELNRKCCGSTESLVGTLVNDVEKLQELGCQLKRLREEHRGIPSGTDQVQHAASAMGPPNKKRRTSDDGFKPFLARLSQLGAQVATLQQEVETRKGECAKWRERYEFAIRSADVPQNNDVFNSLLDEVKRSLLEESKRKNASLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ28</accession>
    <name>F9WJ28_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002673">
        <property type="protein sequence ID" value="CCD17329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21570"/>
    <dbReference type="OMA" id="LSANGIM"/>
    <dbReference type="OrthoDB" id="1446809at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390463" evidence="1">
        <location>
            <begin position="19"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20510" checksum="DBC79C944FD73668" modified="2011-10-19" version="1" fragment="single">MGLKHFFRLFSLVGVCLATTAGAAAVLQLPAEVTSRMSGVWGATLQSPCKPFKVSEAITFSDGTARLESFGLTFTGALEGTKELSANGIMSLAGDMPEDKFRSYVLCAEHRNLMETKYRPGFGSEIHTTELVEYVGHLVENGDPAPRCGLAKFNVFIRVIGSDALGLKEDSWRYKQSLQYVEIEFSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ34</accession>
    <name>F9WJ34_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 86</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002676">
        <property type="protein sequence ID" value="CCD17335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02390"/>
    <dbReference type="OrthoDB" id="1759613at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18535" checksum="DE8F82443A842A64" modified="2011-10-19" version="1">MHALGGGNGMGRGSYGARSKGLPHQRSNRMDYCIKVFHVTATGHRPACSTRDSLPLLFITCGGGLLLCGAWLAAHFAQHVRYPHVLCRIHYISDCVRHPCRAASRSHARSVRMPRRVRKDKRRDCPFQVVSRRVSEEAKYVKSSRTELRRVVQSRKHHARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ65</accession>
    <name>F9WJ65_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 876</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002688">
        <property type="protein sequence ID" value="CCD17368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21910"/>
    <dbReference type="OMA" id="DACTISA"/>
    <dbReference type="OrthoDB" id="745981at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="65433" checksum="913A93C990ADD826" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ93</accession>
    <name>F9WJ93_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 888</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002701">
        <property type="protein sequence ID" value="CCD17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22180"/>
    <dbReference type="OrthoDB" id="1268135at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="222"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="375" mass="41355" checksum="3615B4859FB49E77" modified="2011-10-19" version="1">MKRPKKPFFDVRNMFRTLFLLSQHIFYKKNISLVTPATSTWCQGLVLRLGGSQAPAICPVRKDGGGQEADGYQRGSMQHHRHSGVNEVGRILPCTCGRATLDARRILLLVSGDIERNPGPMIRGAQWNAGGLSQVKRIALERKLHEDMVLFCLLQETHLASAESASLTTGGYQHVGQARIPHGGVGSILVRDGVGVEVGILEKEVPERATVTLRFSADVSLTIISAYFPRKADVSSWALDTLLGANGAMVIGADVNSHHVLWDPLRPSDDKGECIVDWCVQNDMRIANTGLATRRQPGTAALSSPDITLCRDCEISNWKSALSPDSDHHWITFDVFVGTSLDVIAPSKPVRALYSWNKARWNDFKKLSDDFIYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA4</accession>
    <name>F9WJA4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16011" checksum="CB6CE290CA7B9DD3" modified="2011-10-19" version="1">MHLVCPVAASWARTQKGLPFVEATGGVEVRTGACGQATAPRMNFRLPCHVHSEMFFSNKACGCRAWLTCTFQTSSNKTCGGVWEQQELFLCIHICRPLLYGILILFPSGSCTVFVTLVTFVFRYPSLAKACLITSRWITVMYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA9</accession>
    <name>F9WJA9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002704">
        <property type="protein sequence ID" value="CCD17413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22340"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20150" checksum="98A77B4C2F1D6A7A" modified="2011-10-19" version="1">MSESPSSPSPEGMAQDNTPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPFIHSYVSRFSITDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG3</accession>
    <name>F9WJG3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 907</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002722">
        <property type="protein sequence ID" value="CCD17468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22860"/>
    <dbReference type="OrthoDB" id="1684078at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="254" mass="29621" checksum="7A38ADE2C2546DA8" modified="2011-10-19" version="1">MPSLVTLSSFRYFKRNMCQVICYTFAATNFAYPFCIMFLTNFQWSQLGVCHIPIHVHNDFQCSGDVLTLPTCYRRCGSISPHKNFFCVISRPCFRKSMLFNEMLCHIFELMSSVWAFGTDFSGGVSGFCSMFSLYFCSSVSVSVTVHRLRHPARTYTLYFLNIFIYRESDIFIQLLMCGSSFFFFGQTYFVLWSCLTGLKIYRSFTVHIYLRFSKELYVTFALLLVYVARENCYFLNLNGQFHLPQDTVLNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY8</accession>
    <name>F9WJY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_24530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002789">
        <property type="protein sequence ID" value="CCD17649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24530"/>
    <dbReference type="OrthoDB" id="1667375at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="128"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="47930" checksum="B16642F2357580E2" modified="2011-10-19" version="1">MSYSSKKWQSDYIPCRVVYRVCFRSVIVVSCGILFYMIIFILSLKTLIISTLLSLHIFYCDFYTACWIMIMKGVDVIMIIVFMVMGVHAEVEKVVLHTDGFDNLCGIMKSVTGLWNSAIEDYDFFEKMKDLGHKIDEIFFGPKWAGQLGGLLDLPYQFEGKGPKRSEVCGSNSNSSGVPLPKDSMVSAFLCLCAPTSNVENDFCGLQVKDIGKWSDNDDKNVKEVFKIVWGHGYGTGVIEMCEVKDGSFDNMKLEIQNLAGNLTELENTLKVKKGTLGKSGATCNGSSSCANVTAKPAWLDKLEEIKNLANITLATFEEQKKNIVPETKGTTSNSASVPTDTNKPTPTPEPTSPPVSVPKPAAEGPQVSFEHKEQEVRKALEEKPKWEHKRKTEEIQQKRAEDTVTVQGTNETSASFLKYHNWPLCAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W379</accession>
    <name>F9W379_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1015</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000368">
        <property type="protein sequence ID" value="CCD11587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25580"/>
    <dbReference type="OrthoDB" id="1017611at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="PTHR21573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="482" mass="52718" checksum="B93497C1C79F3F41" modified="2011-10-19" version="1">MRVVASNGDKAYFFDFNSNTDIDEVAISSQLYIGEGAKEVHLGKNHLWVTRGRTADRYSLKGDVEVTGVEASHKVVTSSSGDTLLQSVDKVIVMNHNSKTISETECRSCAASMLLSPSGEFKGQVTAEEGLDGFDIKFPSNVVHVPLKGGVAGTPAILFAVYDSDQGPWALVRARNGHLIAVSERNGEMWERWEGLGALVMTVISDSSFREDRFGLWKTALGISSYGLVYSIPFIGMGSNIRVLADISKIVLQGTGANSMESVTVEQLQVSGGNTLHVLTSFGNVKLMVDLNTLTGNMNMASKHVDSLIVTPTFDIKRSLVVKGTIPTQDLHTYTVNTTSGVIEGFLVAGATPAKLLWTVRLPFSIVAFSSGEDALRTSIVNHLRVFPNKSGSTEEVRRKFPMRNVLAVAYYEPVEDEMPTLVVTAIDTITGSVLASVRHRNVEGAVHILIVEHVVLYHFMDVEKMRHSLGVWEMLKRKWDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W399</accession>
    <name>F9W399_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000376">
        <property type="protein sequence ID" value="CCD11607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ITDITHI"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="14419" checksum="F36CFDB462E33C26" modified="2011-10-19" version="1">MSDIAQIGDIVPLGDIAQIGDILQFSDTVQLSDIAQIGDIVPLGDIAQIGDIVQLSDIAQIGDTVQLSDIAQIGDIVPLGDIAQIGDILQFSDTVQFSDILQFSDTVQLSDIAQIGDIVPLSDIAQIGDILQFSDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3H3</accession>
    <name>F9W3H3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1053</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_26460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000411">
        <property type="protein sequence ID" value="CCD11691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26460"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="32784" checksum="0B4A9AA19DBA6183" modified="2011-10-19" version="1">MGKDNGVKGRLKEALYGDAVGASFNEDGVLAGGCGLGMVSRSQYCSHIEGVHPPFFGGSNRNGCFGHSLIGTFLCLCVPGNDRKDLCGLNNVHGGAGWTSSNGEEQTLFQRVWTGIEQKCKEHNTTGHVGDLESAVNNIKEETKRNKISGGNNGYYLGSGTAGATCSNTSPQHGCVTYAPTGNGDTPHIPWADKILEAINISKTHQKASSIKSPQTDHHHEDQDDSSDEASEGETDDHEEEGEEDESTQNHDHQNPATPPRSKRKRRSIQKNTEQPAESLKAILHHDDGSFLPQPFWLLSAVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I6</accession>
    <name>F9W3I6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000416">
        <property type="protein sequence ID" value="CCD11704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26580"/>
    <dbReference type="OrthoDB" id="1655877at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="747" mass="81290" checksum="EDE47FEFAA6CEC52" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X5</accession>
    <name>F9W3X5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000489">
        <property type="protein sequence ID" value="CCD11853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27930"/>
    <dbReference type="OrthoDB" id="1715016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18952" checksum="019A08144F518E5D" modified="2011-10-19" version="1">MSVQRRNEASDKLTHQVASTPSTQHQPGGTRDNELEEILQKAFKFWEDVCLVDFLAQRYGKTYGACDPNVTVATFLENPSHYIENDAEREEVVEKLPEKLHQLKGCILRDVTFLRAVGITTREQWAYRRFYPEMLTSITNCVLSRKYGSPLDGETNKEDTLIVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z0</accession>
    <name>F9W3Z0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28070"/>
    <dbReference type="OrthoDB" id="1728330at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18258" checksum="33297BD1A8FBA795" modified="2011-10-19" version="1">MSRLDEHVQTIHDAKLLTTSYLSIIYQMQEDVKHGKPMKAIVTNARKAGQKGAQVVVGKTGDTSPKASHPTAGEKEEVQVTVQLEGLKYLEEEDPDPAHSNESFPKVYVYLLGLLLPLCCLIVCLTLYCVLRKPRSRSSPSHLDDKGSMPVEAATLGKDGSTRVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W439</accession>
    <name>F9W439_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28580"/>
    <dbReference type="OrthoDB" id="1654038at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="812"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1075"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1075" mass="118542" checksum="FEC6A93575F5CCF1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W488</accession>
    <name>F9W488_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000531">
        <property type="protein sequence ID" value="CCD11976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29020"/>
    <dbReference type="OMA" id="ASWQQGV"/>
    <dbReference type="OrthoDB" id="1392782at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18988" checksum="6782691757A5E470" modified="2011-10-19" version="1">MGIGAIGLILYVSMRDDTVHHTAAVASEALGDVRLRERATQLSKEVVESVLKDKKSLDLVVGLVVRVLQEDDSMIAVSSFLRALFEDHYTQEVTKKFVLMTVLDPWVQEQIRVIAKDLVKDLLRDPEVKKALVKFLSECAATSLHDEKLHHDMAHTVRSVAKQAVNLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A1</accession>
    <name>F9W4A1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_29150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000533">
        <property type="protein sequence ID" value="CCD11990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29150"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001396">
        <property type="entry name" value="Metalthion_4_echinoidea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00873">
        <property type="entry name" value="MTECHINOIDEA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="128"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="313"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="501" mass="56469" checksum="0E4677F30386252D" modified="2011-10-19" version="1">MIKSSYLIIKRKAKKIYFLYYSLFFSFYSSKVKISMTMNCVLTIMIMIVMVIMGNTNEHYNAKEFRQLCKILRVAEGEPEKIPNELGKFMYTRSILEKLLRATKTSTATYQKVVKLSANDEEDGDFISYTVKRKTANAKIQHAMEKAKDIYTRMEEEFIQANKEQTQARNNLVHAIYGVQMGELPKEEEISSVLQNVSRLSISNGNGGVKNVKYHGNSTKPACGGVGENGAGFTLINDFYCLCVGKDNEKKVCHEKIKGPGVWKLESDCKKCEDCCKDGTCCCCCEGDCGNECKCGGECKCGSKCSCIGGKCTKCVLTGTWLSMKNDSDEELELQHGWPHIRKVCNETSTEQVNTTAESIQEVLDEFNKLLGSNSNTDIDTSSDKAEMDARRLFVLGFSKKIDGQGCNGNGQGVCVNYWSVSNLGIGIVWQNYMLEAQKHLKAMDKHIQKVQQLSSMIQKLKESAEESYRNSAHESMLWPLEDGFRKKKIYNFFIFFALFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4C3</accession>
    <name>F9W4C3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000540">
        <property type="protein sequence ID" value="CCD12012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29330"/>
    <dbReference type="OrthoDB" id="1667295at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="43429" checksum="46D81D1223EA8F5F" modified="2011-10-19" version="1">MSIKGSSVWWLVASMFMAWLPMVSVGSLYPKAIPTEAGESICTLSWKLKEVTLWASEKVEALRKESDAYASQLLDWQLHFHESLECEVNQSILEEIRTALGTANEELQKLPKKAIRAGALAAKSAGRLDEFITVFANAQKESFMNQVNYCMTGGGRPARRRDLIDCFPTGSRLEIGETNLAKIPESTTSRNEPNLASEIKNITHSSLSKHWYRYALDSGAECNLIKGASSGILGVNLNGPLWWGGVILTIGKSFSGQIEKTAFNAGEIANATKGSESNKSFWTASPSTAIPHLNKTLAAIQDFKDAEAIITRKFSEIEKIEKQIETCLSNETMEEGHTQSCFKNAVKINAELQAANALLERYHKEKGPPFSRSALIHHQSVVNVWYLILATFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W546</accession>
    <name>F9W546_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_31900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31900"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="33"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="368" mass="40972" checksum="45E1B2F5A0496346" modified="2011-10-19" version="1">MKVMVINTVSILYFTVEGEEKQNYEESKLLCNVFTAATESLRKAKNKRQLTDAIYGAGGSIKFRDDGSIEKDGNFFGQIGWRSVLCDYHEKDVRLALRARSNGCLAESLVGTFSCVCTPGDKNAQGLCGMKDLGSFGTWSGSFSGNELNQTLFKGVWNKLNEICNDGSENEQDYREKLKNLRRSVERIRRKIEASNGIGSLVLGQGRRIPCSGETTRHICAVYQEESGRPDTPWVKKIEVALGELEKKADATNVVPESGAARKGPIGTNKQNREATPSREIEENEEPQEPMARLPNIHRETDDQTEEEDPQSEITGSRGSFSGEPTERGKRTTKKPHITDIPHVATNPNEDGFFLNHPKVVLWAVLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D4</accession>
    <name>F9W5D4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1315</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000702">
        <property type="protein sequence ID" value="CCD12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32680"/>
    <dbReference type="OMA" id="SFFANCQ"/>
    <dbReference type="OrthoDB" id="663144at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028926">
        <property type="entry name" value="CEP76-C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15627">
        <property type="entry name" value="CEP76-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="567" mass="63872" checksum="C8995DE71E0432C6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E0</accession>
    <name>F9W5E0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_32740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000704">
        <property type="protein sequence ID" value="CCD12391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32740"/>
    <dbReference type="OrthoDB" id="1680832at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36402" checksum="D8224D854D07E997" modified="2011-10-19" version="1">MKLLEWQSKFLQSKSKGSGSEECKITSLLFRQVRKEIDKARTGMERLEKEASKAAAFAANSAGRLEEFITVFANAKNSSNGFCLGNGKAATPKELKDCFSGTDFREKSLVDISERVSEQEPNLDSKIEGIKHQSLRDSLGGGNNVGFNLTKGTKGGILKRTKLENSLWWGGGILSIGKGFDGNLGSSQNFGAGEIANNTKEGKHALWTENPATHIVHLKNASDAFKTFKAVQEKIKEKVESIEQQIQACMRDQESGENNTEQNATKHTTTTEQTPTSLTCFDNVVKIAAYLKEKRALLARYQKVKEWIPPNSDFNTKIAVTLFGILLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H9</accession>
    <name>F9W5H9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1327</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000715">
        <property type="protein sequence ID" value="CCD12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33120"/>
    <dbReference type="OrthoDB" id="1726049at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17254" checksum="6ADD1BC72C3C3F0F" modified="2011-10-19" version="1">MLSTFDLIFSWTALKGLKISEEFLRCTIWVAGSSVQRALRTVAFWISQAAMLGRLPANSFPIVKMPPPHQRDFSRFLLFRMPPPAPLIKLQPAFVVLAPAKCELSLLCLMPSTAATKLGSCALYLSLMSTKLSSPKSFLLKQSFNSPGVAALPSPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5P7</accession>
    <name>F9W5P7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1355</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000746">
        <property type="protein sequence ID" value="CCD12499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33750"/>
    <dbReference type="OMA" id="RERECAI"/>
    <dbReference type="OrthoDB" id="234138at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="PTHR14042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388700" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1664" mass="181849" checksum="0110192283CB6E41" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Q1</accession>
    <name>F9W5Q1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000749">
        <property type="protein sequence ID" value="CCD12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33790"/>
    <dbReference type="OrthoDB" id="271662at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="PTHR10887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112230" checksum="195142142A07CFA6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W604</accession>
    <name>F9W604_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000806">
        <property type="protein sequence ID" value="CCD12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03510"/>
    <dbReference type="OrthoDB" id="111565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="21334" checksum="A85CCD90C735F892" modified="2011-10-19" version="1" fragment="single">MQNTSVRLVPVIWKKKVVDVNQQLDDDMRAAVRILKSGDMSTIESMLKGIDDVNWKCSDGNTLLHWAATLSNIYAVRVLLGVGADIDAVNAVGATPLHCATLCGSCETINELLLHGADPTIRNQRGHTVFDFMRDLWADTLYEEYEELERVLLGLDGDEQEADNILLSMGISSNYDLMTKRDLRKTVSMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W630</accession>
    <name>F9W630_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_34950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000816">
        <property type="protein sequence ID" value="CCD12633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34950"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394713" evidence="4">
        <location>
            <begin position="23"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="93"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="305" mass="34581" checksum="C2F2F64185D8A508" modified="2011-10-19" version="1">MIIVIRCTSILLMTVIVVMVSSESDNYNEKEFKQLCNILRVAEGEPKKIPDELAKFSETRNVLEKLLRVTRTSTSTYQKVVQLKSSDKEDADFKSYTVKRKTANAKIQHAMEKTNEIFSRIEEELIQANKERMLARNSLAHAIYGVQVGELPKEKDIPDVLKNVSRGSISNHHGGEKKVKYHDTSKEPACGGAGESGAGFTLINDFYCLCVGKDNEKAVCHDKIRGPGKWEPEECKDCKDCCKDMSCCCCCGDNCNKCKCEKCNCKVLQLWKWAMAKVRSHRHVDETTEPRWCGTRASRWLPHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W674</accession>
    <name>F9W674_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_35380</name>
        <name evidence="5" type="ORF">TCIL3000_10_11600</name>
        <name evidence="6" type="ORF">TCIL3000_11_10200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575323">
        <property type="protein sequence ID" value="CCC94379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000831">
        <property type="protein sequence ID" value="CCD12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.10200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35380"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_10_11600"/>
    <dbReference type="OMA" id="TMAINFL"/>
    <dbReference type="OrthoDB" id="1172076at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC94379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC95548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="24570" checksum="ADB1C9543B6F28D4" modified="2011-10-19" version="1">MSKIPPAQLSEAIQTVLKDRKERKFKESIDLQVNLKNYDPQKDKRFSGSVRLPHVCRPRMTVCLLCDLVHEDVAKKSNVPTMNQEELKKLNKNKKLVKKMCNQYDAFLCSESIIKTVPRLVGPHMHRVGKFPTVCALSENLPEKVLELQSTVKFQLKKVLCLGTCVGHIDMTEDQVRQNVVMAINFLVSLLKKNWQNLKSAYIKSTMGKSQRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N3</accession>
    <name>F9W6N3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36810"/>
    <dbReference type="OrthoDB" id="1667561at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43556" checksum="DD66BB0F72F4AD8B" modified="2011-10-19" version="1">MVDAGSMWWLMAVMFMATLPVPCVSSYYPKAIPTEAGGAICSLSRKLKDVAPWTTGKLTELKKTRDEYASKFLDWQLHFHESSECEVNESILEKIMAALGTVDEELSELHAKSMQAGALAARSAGRLDEFITVFANAKGTAETFYNKASFCFGYKGRPATRTDLHDCFPTGSRFEMGEANLAKIPQSTADGDEPNLASVIENITHSALGEHWYRYALDSNANCNLIKGASGGILGVNLTGPIWWGGGIFTLGKSFNGEMERSKFKHGEIANASKESDSDTKAFWTEKPSEKIPHLQKTLAAFQAFKDAATRISKKFVEIDNIEKQIQLCLSNETMEERPTQSCFKNAVKLNAELQAANALLSRYHKEKGPLPSGSALILHSRCVFTFCYLIAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Q4</accession>
    <name>F9W6Q4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_37020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000912">
        <property type="protein sequence ID" value="CCD12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37020"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="83"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="44629" checksum="99363C750794DC10" modified="2011-10-19" version="1" fragment="single">LLCEAFWSANRVLSYIDKELTQELKLLREAVYGSDKKNALINVSGHVTPSLRCGYPLNGRTPLCTYYRGHPGTVVGLRKDGCFAESLFGTFLCICTPGEEQLPVRNLCRVAGLEYGDKWSGKWGRRGLEDKKTLFGKVLGSVMKACTEESRGEQDDSNGLEKLEKSVNNIKKKLKPGKREGFSYLGGSDNVIECSGVNGQDVCVAHQRGVDEARIPWVEKIEEVLDQLKPVFHRLSTMKASIQAPVASYTQGTAGQPEAPREAGEMIYRRYIHNTFKKYPLSRLERGRRKLKRPGFREAQNLQQSRGKQITKKTTPQPTSGTFPLTPTKAALQKTSHSCFSLPPYTTKQKNFFTSSVLVSPFHHDCQLISLQFTSSQHNHFTSILSLELGGVRNRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7A2</accession>
    <name>F9W7A2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1590</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001007">
        <property type="protein sequence ID" value="CCD13067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38830"/>
    <dbReference type="OMA" id="NWSGREN"/>
    <dbReference type="OrthoDB" id="1568870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389959" evidence="1">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="17445" checksum="91071A07AED3362E" modified="2011-10-19" version="1">MASWRSLAFGLLVCCALLCSDVHVTALTLHRPSYLSQRKMRSAEAGYGPTPMSGRNYRGKVVAVETKVLCDDGTAKTEWVDAILITRGGGCSQGRQALRAQSLGAVGLLVTDDGVGSEDEAEVDIPVERISKNDYASIMVALNNNIVVEATLGIPLNVLRYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K4</accession>
    <name>F9W7K4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_39450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001046">
        <property type="protein sequence ID" value="CCD13171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39450"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389969" evidence="3">
        <location>
            <begin position="25"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="310"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="389" mass="43011" checksum="FA146551B557C010" modified="2011-10-19" version="1">MVESRIIRKGILTILVATVVGIRAREINKNEHKKICDALKVSVGLWKMVQSKEWNPSIALASALGQAIFGNERGGNLEDLKETLPQAYVNPGHRGQWCGSCSHSGTHYPGISIPHDIMCLCSPGRCEEPFHYHYSDSYGCTLRWSWRTLCGKGHDDLGNEYSRGWFSMKSPAKIKQSTGNHTGYLQIPWKETVWGCIKDVLKISEKTHKTLEAQLNILNKTLQDFEKILKGRHTGMHKLGGTDKDTEDYASDEFTFHVRYGSCGDASHGGESKKPWWKKLLEGLTKSSNASREETEAFFNSASAGSTAGYYGGHYQHQQGHATPDGGPTPAGKRPSTTQGNGTQTQESTNITMGTHADGNYTAPRLEMLRSSTRITPPPSWLLNAAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7M4</accession>
    <name>F9W7M4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1629</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001052">
        <property type="protein sequence ID" value="CCD13195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39660"/>
    <dbReference type="OrthoDB" id="545242at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="437" mass="50435" checksum="F94E911F9AFA4BE8" modified="2011-10-19" version="1">MRHGPHDDCTQRYPSISFLLFVFNILKDIGFRGIFRYVCVCGPKGVVEAPRFCVTLFHTLKKKLPYITTMRFPPHNNNKNNCCYPYYYYCYFKMIPLSHCCPGGRLMNGDDEACVDLRRCWRTFMVDSADQSQRQEQGSDAKEAQHHLGHDELTLLRRYRVVGTEEDEQSLFFLSLISPNAELLRATSHLFTQLNFQFRQLAVENEGKVMLLRDYHEEQLTNLLEASNVEAGDMIVGSDITEHFVLKHQRELEELQQENCYTESVLMLELRENFFTFLKTSAHGTMDSLEHGAGWLKLRQDDEQRKHVANISSFCGPRFPVRVLELPNLLRKKLGGFRVKDPLLRPVVVDISPLANLRDCLFCLYAENQAAAQAVEEHLLRLSRQIHALLFFIGSEEEARSILTNKYAELFLTNDRRFAAKVVMSFCAVAPSSQSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7M6</accession>
    <name>F9W7M6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1631</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_39680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001054">
        <property type="protein sequence ID" value="CCD13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39680"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase H type-1" evidence="6">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="365"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="665" mass="74028" checksum="2FE3EF8741C02012" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7T0</accession>
    <name>F9W7T0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_40210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001076">
        <property type="protein sequence ID" value="CCD13252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40210"/>
    <dbReference type="OMA" id="KANPIMM"/>
    <dbReference type="OrthoDB" id="288077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="307" mass="33924" checksum="C77A3BF34A91CA62" modified="2011-10-19" version="1" fragment="single">MTYEGAIGIDLGTTYSCVGVWQNERVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPTNTVFDAKRLIGRKFSDSVVQSDMKHWPFKVVTKGDDKPVIQVQFHGETKTFNPEEISSMVLLKMKEVAESYLGKQVTKAVVTVPAYFNDSQRQATKDAGTIAGLEVLRIINEPTAAAIAYGLDKADEGKERNVLIFDLGGGTFDVTLLTIDGGIFEVKATNGDTHLGGEDFDNRLVAHFIEEFKRKNKGKDLSSNLRALRRLRTACERAKRTLSSAAQATIEIDALFDNVDFQATITRARFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V9</accession>
    <name>F9W7V9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_40500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001087">
        <property type="protein sequence ID" value="CCD13281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40500"/>
    <dbReference type="OrthoDB" id="1718122at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18689" checksum="7ED7A7147FCD5390" modified="2011-10-19" version="1">MTLGLKSTLRSMVFCGWYMRIGELAKISGLAASRIRFYEASGLIQSVERKSNGYRDYTPGTEAVLEIIKGAQAAGFSLEEIRQLMPRSAGGWQHDELLSGLKHKVEEIEVLQQRLAQNKAQLLNVIKGIEGKPEGMACAENAQMLINRLREEGGAPASSTKKSARRAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7X6</accession>
    <name>F9W7X6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1672</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001100">
        <property type="protein sequence ID" value="CCD13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40650"/>
    <dbReference type="OrthoDB" id="1132270at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="Znf_C2HC5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="PTHR12963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-C2HC5" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19356" checksum="3B1B543F70A7B5E1" modified="2011-10-19" version="1" fragment="single">MPPKRWGHALGVGATKTHKEALVSYVRNEIQDNNHLGLLGDELENMVNMLVTCGTREEVHEWCQTLLLGEALAAEVIKRRAKGGPPFQDGPVKPGKTQAVSHGAKGSRMLNLCTQRRGKSKASLNQNGNNSSDASLPKPVFFECGCFATEHSLRGNCANCGRIICEKESDEMCYSCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W842</accession>
    <name>F9W842_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1703</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001134">
        <property type="protein sequence ID" value="CCD13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41260"/>
    <dbReference type="OrthoDB" id="1080655at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="PTHR34496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="473" mass="53469" checksum="F924E6A78B69B677" modified="2011-10-19" version="1">MLLQLPSRYPVLTQKANIIARDIVRQAWKGSVLCNATRTSSNNGKAEEDMDTYNCDSNQKRKRDKSTDTSKRTPSPLRSRLDHGCAAGTLDLNSGSDNGQCSRGLWEEDVVEFLFRLPSDDVETSRSYGVDDHMDEAELVFPKTVGDHPSFRQSRRPNRIQLYWMRKLRETLRTELKKRMSEWDTTTFICGVMVKVLDELRVKNVCTEGKRHCGAGMGNTSSSEEGGGILRLRTNSVRRLSDTLHDPQYMHPSPLHRCGDEWPDATCLDAGEQNSPRQFPPQPWLSTDFLFTRAEAFFNLSETGTHGRRRRVAEGKEGVGYVPLDPYLALLTPDEEAVLLAARLWTHGWDLYAGTEPIVFAASNRSSTAYSNRSGKAPSVASNAKWRMRRRSLSRLRFILFGESRSEEDMGDNKAEVLKFIKRYGLGSQRSWESFLQHVGLEQDLGGEVGSGATEQDKTDGEWRHYMKACDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W874</accession>
    <name>F9W874_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1712</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_41530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001145">
        <property type="protein sequence ID" value="CCD13402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41530"/>
    <dbReference type="OrthoDB" id="1759839at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388797" evidence="2">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16650" checksum="DA6BF399A875A180" modified="2011-10-19" version="1">MPAQTAKGNSSLHVHLLLLVVPLTKHGSPWPYFFRLRFTASVCFVELPPPSSIPSAVHTPSLRRLRCIDFFLSPSCTISSSPTPGFVELPWRFLPLLFFLGFFAVPSSPIFRGLWHTLSGCNTDFIALTSSSPKNPRISLRKASSLPRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F3</accession>
    <name>F9W8F3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable eukaryotic initiation factor 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TCIL3000_0_04480</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL3000</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001166">
        <property type="protein sequence ID" value="CCD13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04480"/>
    <dbReference type="OMA" id="ANCLDVI"/>
    <dbReference type="OrthoDB" id="245118at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="16">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="322"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="536"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="110"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="930" mass="101769" checksum="C23ED7F343378A24" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8K6</accession>
    <name>F9W8K6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1741</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001176">
        <property type="protein sequence ID" value="CCD13540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42840"/>
    <dbReference type="OMA" id="ESCLESH"/>
    <dbReference type="OrthoDB" id="846149at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="585" mass="64904" checksum="EF442E26245CAECC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8T7</accession>
    <name>F9W8T7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1776</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001215">
        <property type="protein sequence ID" value="CCD13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43610"/>
    <dbReference type="OrthoDB" id="319575at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="565" mass="63736" checksum="1555DE53CDFE5820" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8U8</accession>
    <name>F9W8U8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_43720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001222">
        <property type="protein sequence ID" value="CCD13634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43720"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="357" mass="40095" checksum="59D0B5D5251CF6B2" modified="2011-10-19" version="1">MRRVVRFRDFDYQVWTDGSVVLDVSSGAGALVYPKEGRRERVVLGAGSLARSYRAECVAMEAWLKRLVDVIELNQTHRTRVVAFTDSLSLLMALSTGPAVVEDAILRRVWDLILQLVRLRVSVNFQFVFSHCGVPRNEAADKEAEQGNAKPQMYPAWITDIVAAVERQVRNEMYKDFEEGRMLRTHRSVLLDHVRPEPKHTKPGRLGESLLAQFRTGTSKHFGWLHRVLTRKTDRLECRWCSAKDIGGAAAEDHPLAKPAVDSANAPDFGIATRQSDPIICPLCNMVCARRHGGVVHLVKIHGLERDCALTMTKKARRAALTYKNGYTCHVCGDAFERRGLLVEHMAQHPPDVAPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W917</accession>
    <name>F9W917_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="106" mass="11567" checksum="DCD6A81658147F1A" modified="2011-10-19" version="1">MGGQCTTREGLVACMTFLTSRGVASVVLARCYSALVLERLIPMKDWVHVKYCGKHLANSLLMSSEAAPDNGATARQPLSHTCFSLFGFLCSTCTWCFYNALPSFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W982</accession>
    <name>F9W982_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="7">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="7">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="7">PHB:PPT</shortName>
            <shortName evidence="7">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_44740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>4-hydroxybenzoate + an all-trans-polyprenyl diphosphate = a 4-hydroxy-3-all-trans-polyprenylbenzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001278">
        <property type="protein sequence ID" value="CCD13773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44740"/>
    <dbReference type="OMA" id="WAFASEH"/>
    <dbReference type="OrthoDB" id="1343847at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031305">
        <property type="term" value="C:integral component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002083">
        <property type="term" value="F:4-hydroxybenzoate decaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047293">
        <property type="term" value="F:4-hydroxybenzoate nonaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate octaprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allylic polyprenyl diphosphate-binding site" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="490" mass="55282" checksum="EC5E0E6A9B745725" modified="2011-10-19" version="1">MMRRTLFLRRVPRSWTKDAIGKSTAHFPDSVRVDPMEGRTAANSPKESRVWSMDDAQVPGRRRAPRHIEWATQKVRVWAKLARIDIAAGALLLVQPCYWGASLAVTQALVWEGADPVVLFAPFIPVHLLVLFAAGAFFARSAGCIINDMWDRDIDRMVERTRTRPLASGAIGMKEASGLLVTFLGFAFVIALNLSPVALVSALAMTPIAAIYPFMKRVTYMPQLFLGLCFNGGIFVGYAAVLNRIDFAVTLPIYCSAVLWTILYDTIYAYQDRADDLKCGVKSSAILIGDRKHILTFMIFPIGAGILISGLMVSQSLPFYISVFLCIWYLQGVVDNVNIYDRWSCGVGFRRNVRFAFFVLLSMCLGNVLWALASEHQPEQDAKSNTVSEKSALMKFLLLNRDAEPMPYNVEDVRWVDRFAHPAFIVAQQARSRGEEEPLVVPAWMRREYFGENVGTIMRFLGVDEETIQAWQKWWYAQLDHYNMFSSIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9B3</accession>
    <name>F9W9B3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_45050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001291">
        <property type="protein sequence ID" value="CCD13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45050"/>
    <dbReference type="OMA" id="EEMECRT"/>
    <dbReference type="OrthoDB" id="1667114at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394788" evidence="5">
        <location>
            <begin position="24"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="84"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43735" checksum="1B98B4C7F423C16E" modified="2011-10-19" version="1">MMKLFMVMMVVMGSWVREWGVKAQGGLTVSQDDNSEYFALLCKIYNVAHNPPIKPVDTKEYQKIVDDINALSAAVNGKEGVNTQSEEARSAQTQLVGITREAHKLLNEIRRVNPEGEVERARNTFNQVIFGEHGKEGDLYHGTLIRGQNRMAACGGKTQGKGTSAGKNLVVDFFCLCAQHNIVGEGIDNVCGVTVGSDDGAVWGTTLQLEYTIWKEVKNGCEKFATQGVTSTQDGFSLYHKFLAKVKEGGKVKVNNSGTVHKHGMLGTAVSDTGKTDFNCNGKAVSTGRVNVAGVCIFYGNQHQEQNIKWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKANTQQEEENIDDSPLAQHPNSDENENTDSSTQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T5</accession>
    <name>F9W9T5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1895</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_46740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001347">
        <property type="protein sequence ID" value="CCD13990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46740"/>
    <dbReference type="OMA" id="HATSAYV"/>
    <dbReference type="OrthoDB" id="119789at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="24427" checksum="0245B500A6519181" modified="2011-10-19" version="1" fragment="single">MHIKNILISGFRSYREQCFQESLSPGNNVVVGKNGAGKSNFFAAIQFVLCEKFSNLSAAERKDLFHVGSGRPVLAVYVEVVFDNSDGRLVIPGRPEEKEVRIRRTVGLKQDEFRVNDRRFSALEVRKLLESAGFSATNPYYIVEQGQISNLANMSDEERCQLIKDVAGTRVYEIKRKKSEKILEETEVKHEKIEESIAKLDERLAELRAESSELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA53</accession>
    <name>F9WA53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_47730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001394">
        <property type="protein sequence ID" value="CCD14109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47730"/>
    <dbReference type="OrthoDB" id="1686262at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388892" evidence="4">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="29466" checksum="7C78D02D68AD1E6C" modified="2011-10-19" version="1">MMKLFMVVMMVMGGWVREGRVMANTEVSVDGNDNREPFELLCKIYNVAQYPPIKPVDIKEYQKMVDDINALSTAANGKEGVNTQSEETKSAQTQLTGITRDAHKLLDGIKKFNPEGEVEMAKNAFNTVIFGENGKEEDLYHGMVSGVQNRITACGSKEKEGTGAGKNLVVDFFCLCAEPSSDDEVVEKVCGVSVGRGRESGWGGTKLVSPDTMWNEVKIGCKNVAPHTVTSTQTGHSLYHEFLTKVKQAETLKSKTQVSFINVVCLGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAE0</accession>
    <name>F9WAE0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_48490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001419">
        <property type="protein sequence ID" value="CCD14201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48490"/>
    <dbReference type="OMA" id="VFHSRPC"/>
    <dbReference type="OrthoDB" id="1385616at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="233"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="469" mass="51990" checksum="6699116600F3F4BF" modified="2011-10-19" version="1">MATNGMRPLTVAEAFAETAKALQQFSIERVRIEGLSSNEEGAEEQIKTMSESDFMREFVFHSRPCIIVGALHDWPAMHRWRDDGYLFDLDGKLPMVYPCEEKCDDDRCGSESSGECDTENAGDGLGDESVEVHAGNDDAPEPVKTLGPRRVTVALTPNGRADAVTYVTYRSKGDEDKNQGDGNGPVVTEKLFMSAAEVRVTLPELYRLLRANPPFPPLKSQFVDLRRPHSVIAYAQMQNNCLNKEYDHLHDDISTALDQFGARVFGGPHEAANIWLGTPASVSSMHQDWVENLYAVVRGVKEFILVPPWEGVFVPKPEIPAAAFSISCTEEKVTGSHHSPGGVRYAFNDVPVRDGTSVGWMDVEITPAAVEDPQYMKEDLRDKLHPLIAYVQPGEVLYLPALWLHRVAQHADAKDSDAISGPLIEKNHSNGLQGERSKPLPLIAAVNYWYDMSFVNPAVVMLREFGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ7</accession>
    <name>F9WAJ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17286" checksum="51D4A64E1AF5A536" modified="2011-10-19" version="1">MTNRVRRFEHSTDLRRHATNPPYPHVHDFRIRLIHLEKLPRHLTFPWPPTFRRSRKIYQPQGQHPELPQEAGKMFPYFFPSVGVSHASPRVLGKASDTKPGNVGMNKWIRGLQETVQVDALRTSNALQEYLHHILFHAPGGVFSGHAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAK0</accession>
    <name>F9WAK0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49140"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17669" checksum="92C49738ED0731CF" modified="2011-10-19" version="1">MHLKISKLLRVTFKKFSLKCGITLVTPATSTWCQGLVLRPGGSQAPALCPVRQDGGGQEAEGYQRGSMQHHRHYAVNEVGRILPCTCGRATLDARRILLLVSGDIERNPGPMIRGAQWNAGGLSQVKRIALERKLHEDMVLFCLVQETHLASAECVVLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAM7</accession>
    <name>F9WAM7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001455">
        <property type="protein sequence ID" value="CCD14297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49310"/>
    <dbReference type="OrthoDB" id="1756979at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390063" evidence="1">
        <location>
            <begin position="26"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13996" checksum="5FF818544B86D75A" modified="2011-10-19" version="1" fragment="single">MQKLRRLMCRLWVHMLAIIRYLAWCNIQTLQEQVEWQENTRIEAITQFILQHAIQNAALAPTSPFLSSFFLPFVSGADAESDDDLDTRTSSEINRLGRFQNRLAPAQAGTVGIGGGRPGSDRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN1</accession>
    <name>F9WAN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1995</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001458">
        <property type="protein sequence ID" value="CCD14302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49360"/>
    <dbReference type="OMA" id="LCCAINV"/>
    <dbReference type="OrthoDB" id="512892at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="550" mass="60632" checksum="E0CA8534E1E7C8AB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN3</accession>
    <name>F9WAN3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001459">
        <property type="protein sequence ID" value="CCD14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49380"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17114" checksum="3CAF4050BFB5E2E2" modified="2011-10-19" version="1">MAPLTCGMSGVMAGVSHLVACPQAVASFSGGSRALCEGTESERHGHTSGIMKALMGLRCLLEAYSLLSLRAAADVTTSLLDLKALFPHVELPCEALRLFCCRATNSDEWRELSPVLVSGVSRVSSHLSVRCVARAARAVFELTNKVLQQQWQDSHGTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAQ0</accession>
    <name>F9WAQ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2003</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_49540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001467">
        <property type="protein sequence ID" value="CCD14321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49540"/>
    <dbReference type="OMA" id="FRNSHGV"/>
    <dbReference type="OrthoDB" id="1680738at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390073" evidence="2">
        <location>
            <begin position="33"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="311" mass="34113" checksum="C0D32A8FC8975614" modified="2011-10-19" version="1">MSVFIPHVPPSPRRPPDLRVPLLLLLLVVCGAAPGSTTNLTVKVFNLYHSFHMSNLYLAAIVAGFNASLASRDSTVPLRVHVETAPYLATNETTKQFLVDHMTNENGNELPIVLGPVGDRNTLSVVSLLKEKNVVALAPFTGSSNVRGWNKNLYFTNAGPTMELVALVRYAVNNLRLRRLGFMYLKNVSFGDEEYTLAVSLMAGIGRQLSGVFTLNIVNGQAAVDDEFHAEWERFAATQPQGVIVFGSPLADTRRFLKQMVIDNRTRMAYVLLPSVLQFIVVSSEGAARAFRNSHGVVLCGRRLAGRAAFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAS0</accession>
    <name>F9WAS0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2011</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001475">
        <property type="protein sequence ID" value="CCD14341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49740"/>
    <dbReference type="OrthoDB" id="50498at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1241" mass="137770" checksum="CF73706CDEBA179C" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT8</accession>
    <name>F9WAT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00630"/>
    <dbReference type="OMA" id="MWAPHKT"/>
    <dbReference type="OrthoDB" id="936176at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="PTHR12968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="506" mass="55854" checksum="12203AF76B1074BC" modified="2011-10-19" version="1">MDVLQFRRAERYISRVPLHGLSFRATLWRAPLGEEHRLEQLCTITVPWGGKVLSPAEELQEIQATVGFSGSSSRCLTAASNACEQEMDNMAATSSASDRRRNAVNVINKLQTKLAKFSNVIFTRPPSEDFIDDTEEVSPVYPPQAVCPLVPVVLREHRAQHRPCNKMFFVCANGRIICPSEEPLLNCQWKGKELVMCTVASAKDGLNFLAKPSINKVHTLLVDPSHVYLFKITVLQTQEASIDQPMQSDIVRKIDSMATQVEGSVDPSRLSRNRILQQILMQGIPESPSDERPPDIKTPFHFLQPSLRDGRVRYHLFGILERCMHFSVDSLYLHCQWQHEDMCASDSGSSCGGKTSDGFTTQLTFSSGVIVEQYIPTIAHVFNIPFEYHFDGSGMAPLRLVVTAFSDEGFSTGEPQSPVGYAAVTVPHLLPGNHSIRAELWKPRMTGREFVHSAMVGGAPALVDPSSAGPNYGDGITVKCGLVTEPSGIIELRVMVLHQVVSPSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU4</accession>
    <name>F9WAU4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001481">
        <property type="protein sequence ID" value="CCD14366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49850"/>
    <dbReference type="OrthoDB" id="1667513at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005678975" evidence="5">
        <location>
            <begin position="24"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="100"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="389" mass="41441" checksum="D40F741F195A3237" modified="2011-10-19" version="1" fragment="single">MACLMNVLLASVVICSIVKDAAAQGAQVQGVDNAEQFALLCRIYNVAKNPPINHVDLQDPVMIVDEIDAIKASFVEEKPLNKTENVGSSSDGQVTLTTTGEPAVAQALINRITQKAHIILEKIKKTNVTEEIEKVKAEFAQVIFGEGGSEGDLCHGALSGVAQRGAACGTPGTGMKGNSAGNSLVVDFFCLCAMRADDGMENACGVRIGGKSSKPDNHGWGSTDGPLGSPSMWASIKKECGTLLHHHPKSTGEGEEILEEFLRHIKLGGVYRWGTTSNVQGSGKKEGMLGTGVGNNDGDHEGGLLCDGTRGKKGVRAVRGNGENTVNPGGVCVYYGPKSEWQNIPWLKKFQTALEIVDVANNQTAIIQRAIEKLQTLLRRAEEIYETTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU5</accession>
    <name>F9WAU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001482">
        <property type="protein sequence ID" value="CCD14367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49860"/>
    <dbReference type="OrthoDB" id="1744341at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16051" checksum="77AF5F1C3CFDBB3B" modified="2011-10-19" version="1" fragment="single">MHTTESHESLLTTNAAFALLAGTHEVRSGRVTRKARDCGPVRSSSSLHLIVDSQRSTEDNSEHTNEYQLVRHDIVEPPNLPHGEVARVHVVKRRENKCEKATAEAPKEVEHHLXAGSTRPEQGPASRARRSHQVLPRRNVDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB61</accession>
    <name>F9WB61_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2066</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001537">
        <property type="protein sequence ID" value="CCD14492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="WSDIRGN"/>
    <dbReference type="OrthoDB" id="1655655at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1067"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1161" mass="126973" checksum="787B1B3F8E4EBF52" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB87</accession>
    <name>F9WB87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_51260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001546">
        <property type="protein sequence ID" value="CCD14518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51260"/>
    <dbReference type="OrthoDB" id="1663189at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394650" evidence="6">
        <location>
            <begin position="24"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="88"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="46404" checksum="C7FC2FA9F8C27D1F" modified="2011-10-19" version="1">MAFFMNAIAVAIFTCSIVKDTAAQGAQVQNNDNSEQFALLCRIYNVAKNPPIHHVDFQDPNKIVDDIDTLNSSLYEEKQHNETEHVGNSSDTQPKPTTTREAAVAQAILRRIAQKAHTILDEIRKVNATRNIEKVKGEFAKVILGEMMNESHLCDGALKDVKDRATACGNTGHSSKGASAGKNLVVDFYCLCAMRVESIGRDQDGIENVCGVYVGSSKKNGNHGWGDACPVTSSTMWASIKKECGKRLQHHPKSTKDGHEVLEDFLKHLELGGVYRWETTGKESSRKAGMLGTGVASEKEGKNILCDGKKGEKNGQPPGGVCVYYGPSDWGNNIPWMVKFKTALASADALNNKTATIQRDIDKLQKLLRRAEEIYHTTQVISEIQNPAVPKDFQTAAKRLTAYSADRKHNTYHFILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBI6</accession>
    <name>F9WBI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001584">
        <property type="protein sequence ID" value="CCD14619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12611" checksum="D88DF61D035BDC04" modified="2011-10-19" version="1">MRFSHVTLYNYRTPHTYVTNDIANIVIYMYICVCIYVKKLCNIEERSIVSPCNSVGRQSEGSPPPPEHAFLGCPAPPSAQGLRKHGQRSRARYYAPATGTVHHSSPLPQLCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBY2</accession>
    <name>F9WBY2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001642">
        <property type="protein sequence ID" value="CCD14769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53570"/>
    <dbReference type="OrthoDB" id="1722942at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17448" checksum="ECC8BF2A976E1A14" modified="2011-10-19" version="1">MMEEQDSQGLRENADDLFLFTESSCRNREQLLAQARKPRHGIFATAEDTHKKQREDDFFLGQETSTEIENLDFPTPEDLSAEASLHLPVVELLGGLSAQGAGNASPNLNDHTEIAWPMPSHLFTTPLTATGELQRHNSLQAFYQAHHAGRPTLHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC40</accession>
    <name>F9WC40_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001664">
        <property type="protein sequence ID" value="CCD14832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54100"/>
    <dbReference type="OrthoDB" id="286655at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="18065" checksum="470635650E6F400E" modified="2011-10-19" version="1">MPTYVWDAVSGHSNDARLRERNLTSFIKILSMLYDVVDSSQRGVEALEEGIDAYDTPPRARQWLSSAFSTGAKLFAAWLTVDGPREVLSVCTSTCVNFYWMAWNCILWQLQEIWKSLPSSWPCALDRGCVSGEVMRFASDVMHDYCKGRSPGHRCRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG7</accession>
    <name>F9WCG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001721">
        <property type="protein sequence ID" value="CCD14960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55280"/>
    <dbReference type="OrthoDB" id="1660539at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="478" mass="54737" checksum="62E5F3593BD720E9" modified="2011-10-19" version="1">MREVVDRLRAMGIISLHQWESAAAANEVEDVDACVRGVLNAARLSARRNEETIRVGNAPGGEEVNGVYDAVFNARWSYVVRSGEYDKKWLGMGVLRDGEGEQPRLWSEAQADVPYDPEEPWEGDVVPGVSGKLVMAALKSHKGWPHTLLNASAPEMVSANVLRKYKDVCNAHLHIRKENVRVWNIVKKNIDEWLTGLKKVHPFLLIGTRGIGKSFATGSLLLYQLLHSPSEWLKVVAYFVREKAYIFHRKERRVVYYRKQSAAVGKIKGMTRRGICGYIIFDTGKESIGAGDLVGRWGIILISSPNEKKFQKIIPQRPHALQIYICCYEDVELKAALVWERHWQLEKKLIKLEDVNLENDWKVLKERIGMIGPLPRYVLANKSAYEKRLKDVKSALGLISHDIGRYSELLCNPHKWHENGTTHKLMKVTRRRVHGKLMCWDEPISTYVWKELQRRAFTAPLTEDVIRRVLFSKQAQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT9</accession>
    <name>F9WCT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001762">
        <property type="protein sequence ID" value="CCD15087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56500"/>
    <dbReference type="OrthoDB" id="1692074at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25273" checksum="541A1BB70B4C7844" modified="2011-10-19" version="1">MVFEVELFVKEAALDTANYVTPISEDQRINFVTYDTLFKRDDCDVPALPLTLAGSIGLLDEQIVVSGVAPNARYELGEIFRGAFIGDLNISFSTIVRKDAEQPVEPSLALSGTLVVPECGSYFCRLDRAVMYRHFESMTVELAEVHLTDLVTLTNSLAWSSAKCPVISWARRIPMFFSVEIQINPSELRSVGCGTVKFGGSQGDVKVVMSPQGFGAVAKLSNVRTGGICLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCW2</accession>
    <name>F9WCW2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001780">
        <property type="protein sequence ID" value="CCD15110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13856" checksum="3722443ED4D0C8E8" modified="2011-10-19" version="1">MVIRRQTNTTRLVDSNATFSTLEKQSHKYTTIIKCTIPEKRMNLKFSLFSVMHFYGVVSWCDGEFTTTIRDYLDLSKINNLNTYLQNCKHVPVSEFYHTRHDHNLYDQLINLPTCIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCY0</accession>
    <name>F9WCY0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001784">
        <property type="protein sequence ID" value="CCD15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56880"/>
    <dbReference type="OrthoDB" id="330091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="48004" checksum="286FEA936BB85F59" modified="2011-10-19" version="1">MFVVMDLLDGGMLHDRIRSLDHYSERSASELIGNVLSGLAHIHAKGVIHRDLKAENLLLRKRSDKRDDPWLTDVCISDFGLATTGPAFSCCGTAPYIAPEVIELGYFHRSREPYDAKCDVWSLGVITYILLSGKWPFSGSCHDAIFKRIVKGKWRFSGDIWNKISAEARDFVRKCLTRDPNKRPSSRELLQHRWITEAQRDCHLGSSLGALRSCKALSKVHSPPAAPRSTCGPLPSLCNSVNNSARSWSSFTKYLSHSDRLSMLVEVRSQSNHEVVHHVDFGKALSTGEGWRLQDCCTCGSTLLCRHIQQVHEYLFVGSSRAKLRPFVYHLRVMQTEAERTMRRSHNDRESAAEVFYTIENIIGAAIAFSAAFKAVPAERRRGRAWGSKASRRACEETKSLLMCNKDPKLWFAGDPTTAARCPATPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD41</accession>
    <name>F9WD41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001818">
        <property type="protein sequence ID" value="CCD15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00710"/>
    <dbReference type="OrthoDB" id="1719527at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21118" checksum="8BFBF9FC1FD7019A" modified="2011-10-19" version="1">MSPVRQSYFRPIHTSPSISLCPTLTASSQAVAADGGLCDAPRQMVRGSHISLAGLKLTHIIEHSARLPKAFPFTTSGTSSGSHTHTHIRSHQDATCAPMDAATRSHAFASRRHHRLPTHHMPQPPDRLIGAHQTHERHNVEPYAQSGATLLISNGAPRAQISHFHFPLPNKANSPRTNTARHNHEEKQWKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD59</accession>
    <name>F9WD59_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001825">
        <property type="protein sequence ID" value="CCD15210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57540"/>
    <dbReference type="OMA" id="CCSADYR"/>
    <dbReference type="OrthoDB" id="213762at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="837" mass="91106" checksum="895BEE1E9FE30EEE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ0</accession>
    <name>F9WDQ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2387</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001894">
        <property type="protein sequence ID" value="CCD15404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59310"/>
    <dbReference type="OrthoDB" id="1529628at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19780" checksum="4D385E6BE1B5AB58" modified="2011-10-19" version="1">MMMRCASLGFYVSFSLLSFCLGRVKLYRVPWMSLREVVSKQLLRQAVLQPRLKLPAGRIISVEEGWRLARLVHEEEERTAAAASGAAADGVVEPSAVVLEDAVAKRILLLRQRGKTERNVRATVGHAQDRRAPPAARDAVFDVHNNIAQKLLRKGSGGFSVSERRHMRKGSGKKPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE70</accession>
    <name>F9WE70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16400" checksum="EE6F3515411EC35F" modified="2011-10-19" version="1">MDGHPPPAPATSAAVVHISISPGSSSLNPWSTTWIHSLSTVPWPCPRAPSFSSGSVHPSSVFLSLLNHLVQFCQFQSPKRRCYTLALWNNPLCSHPNARCDRLVQGIRTLGRPLHSSENKIVTQFSKIVPTRLVPRVKCTCRIGGRNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEB6</accession>
    <name>F9WEB6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_61060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001969">
        <property type="protein sequence ID" value="CCD15623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61060"/>
    <dbReference type="OrthoDB" id="1716672at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17261" checksum="A2FE45B71A19927A" modified="2011-10-19" version="1">MGYTGCYAQVARARASWPGTVPVRTQVWGRESSPETRPLGQTVTGHCAADCLHGTNIGAMFRSACGQYWAPFGTGITDFAWRVRVRKLMWDTDCLEQEQLKGIQGGAVWENIRRCAKVLRESTCDGGEAPKCILVSRLDTSKSKKSVQAPLILRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEC7</accession>
    <name>F9WEC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001991">
        <property type="protein sequence ID" value="CCD15634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06530"/>
    <dbReference type="OrthoDB" id="1760570at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="16972" checksum="D979C43EB50BE705" modified="2011-10-19" version="1">MAPLACGMSGVMAGVSHLAACPQAVASFSGGSRALREGTESERHGHTSGVMKALMGLRCLLEAYSLLSLRAAADVAASLLDLKALFPLVELPCEALRLFCCRATNSDEWRELSPVLVSGVSRVSSRLSVRCVARAARALFGLTNKVLQQQWQDSHGTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WED5</accession>
    <name>F9WED5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001993">
        <property type="protein sequence ID" value="CCD15642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06610"/>
    <dbReference type="OrthoDB" id="1721256at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17463" checksum="8A08C98594215015" modified="2011-10-19" version="1">MHRGCSLGIHSYVKLLCLYARNLVGIGHLSVVPGSSALNWPPHGLGQSQQTDAGQTHSESIAAFPTVWSEVNEHGQALSCVCGHGNSLLCRLLLFLSGNVEYNPGSMKLLIPSGCYQPGRLQQHRVTFCLSDTRNPFWKEVVEMRSLQLYLVFNILAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEG7</accession>
    <name>F9WEG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 262</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002007">
        <property type="protein sequence ID" value="CCD15675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06900"/>
    <dbReference type="OMA" id="ADYWVGI"/>
    <dbReference type="OrthoDB" id="1527264at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTPase_I-T" evidence="1">
        <location>
            <begin position="7"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="19940" checksum="3BD785BED54E0755" modified="2011-10-19" version="1">MIIWAVGTINRAKLDCVTNTTRKCFPDKEHKVIPVDVTSVVRPQPMSADESQEGARHRALEAIRLIPEAHYGVGLEGGLEKIGEKWFECGWMYVVERSSGRCGIGSTGRYEMSQKLMRMILDEGKELAEVMDELTGEADVRSGQGAMGILTAGNLGRAEAYGHGLTFALAPFLSDSKYWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN7</accession>
    <name>F9WEN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002043">
        <property type="protein sequence ID" value="CCD15748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07590"/>
    <dbReference type="OrthoDB" id="1713184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19647" checksum="8C5967530047A03F" modified="2011-10-19" version="1">MVMHASYLPWECEAERSRASVLSRYRLPASIYSFEAADQQCRLEEKWLYKPGWKNFPIACGFFLVDAVSEGVSLSEGAEAPTQAMVLLKVTKTRYHHTKTSKVKRFLNRMAETFTNWDEMESRLRCEIIYLLHADSATIKTRQRCDSGGMACDAGIEEFCDGIGQLLVKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WET0</accession>
    <name>F9WET0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002060">
        <property type="protein sequence ID" value="CCD15796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08070"/>
    <dbReference type="OMA" id="NVMRRVG"/>
    <dbReference type="OrthoDB" id="749952at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="42560" checksum="92540F62C35BF043" modified="2011-10-19" version="1">MSDGAAVAVLRPFPSSERPMISLSFTLRCEAVAAGINCADSSCSTSQLLRFLAPGCGAEGLSGDVERILLSAIGRALEAYTGLESARLTAASHLLGLSLENTRCLVDFLVYRPPIVSKPLAALLKFVTVVVKHAPPEVLRDEGNNILSALLQLLRCLPRSDKTPEPLSMLRAVRVTVRNVMRRVGHHLVGKGEDTTHKCKNGGQLLVDNDLIPWIERHLLPLNVVTGVAAREELREDRRLALALLAYVPAEGISPIAPPGPGRRLGLLYLAEAVIALLRGVAGPDELEDSEEEQARDFLRRVDAVVSSPVISRPDFSGAGLSGDDDLCGHMIPTDVVSDFLLAKDAAYQQDFELLERFISREYCTQASLEQRLCELGHTCGGLMYQPDDAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEX1</accession>
    <name>F9WEX1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_08380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-glutaryl-L-lysyl-[protein] + NAD(+) = 2''-O-glutaryl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11875"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87828"/>
            <dbReference type="ChEBI" id="CHEBI:87829"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-malonyl-L-lysyl-[protein] + NAD(+) = 2''-O-malonyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11878"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87831"/>
            <dbReference type="ChEBI" id="CHEBI:87833"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-57 and Arg-60) that bind to malonylated and succinylated substrates and define the specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01002072">
        <property type="protein sequence ID" value="CCD15837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08380"/>
    <dbReference type="OMA" id="SMQVYPA"/>
    <dbReference type="OrthoDB" id="1459156at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061697">
        <property type="term" value="F:protein-glutaryllysine deglutarylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="95"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="244" mass="27133" checksum="888AE1B4704AA9A4" modified="2011-10-19" version="1">MRRRGRTLAILTGAGISAESGIPTFRDKNGLWENHRVEDVCSPRAFLHHPLVVQRFYNQRRRALLSPEVKPNAAHMALARLERDYTKGEVVVITQNIDDLHERAGSKNVVHMHGELLKVRCTTTGNVFEWKDDILHGQTKCACCGALGTLRPHIVWFEEVPLYMDVISDVVEKADIFAAIGTSGNVYPAASFASLAAANGAETYELNLEPGENSEDFQHNIYGPASVVVSKWVEGLLRGRSRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEX3</accession>
    <name>F9WEX3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00930"/>
    <dbReference type="OrthoDB" id="1702071at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17532" checksum="7A854733A26A22E1" modified="2011-10-19" version="1" fragment="single">MAEEKLKEVNEKADEAELKVQECGKEVLQKARECWKKVQERGVSLLETPDFQSLEQALTNKPWEPRPEEAEALATVCKEFRNWKNARQKVVACEEAVNKRFQELGEALHESEETCPKFPLSDRGLEEVSEGSEEAEIRFNKAKKKLGTAKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFB0</accession>
    <name>F9WFB0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
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        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
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        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394726" evidence="1">
        <location>
            <begin position="25"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="559" mass="60965" checksum="5C6707AA8CA90257" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH4</accession>
    <name>F9WFH4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002144">
        <property type="protein sequence ID" value="CCD16046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10140"/>
    <dbReference type="OMA" id="ANKKCEG"/>
    <dbReference type="OrthoDB" id="1654229at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1066"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="603"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="743"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1177" mass="136674" checksum="3873529D36861717" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL8</accession>
    <name>F9WFL8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 401</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002160">
        <property type="protein sequence ID" value="CCD16094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10570"/>
    <dbReference type="OMA" id="CEGESKY"/>
    <dbReference type="OrthoDB" id="1433036at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="321" mass="34001" checksum="D7BCB92EDCF229ED" modified="2011-10-19" version="1">MMRLAGDRRKRDNGHGLSLMYPLRPCFVVLRVGRSAVESIASSRLCLAFSPLLLGEGVASNVTLAGHVQREAFFYIMSHPSICRPVYLAWSVQRVACVIGRCSPAPVSSAANLTAWLAGQPLLQQVIAIGVHGGLASSVAAAVVQVGGRTFVLLRRALSDSEFSQLTLQQYRHDVFTILVSAGSSVVGGSCGAVLGGLALPGVGTVVGCFVGSLLGGLAPYKVCGEGPEKEHRRLMEHCCNPTRPLKVLDDDDGWLVVSDCEGESKYIFFDRLDNYTEDLTVKSVSESSVCGVSNASGDCDSVVDGGVSDLHDWDEVLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ3</accession>
    <name>F9WFQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 415</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002176">
        <property type="protein sequence ID" value="CCD16130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10810"/>
    <dbReference type="OrthoDB" id="1696708at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="89"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="236" mass="26273" checksum="15232037BED09E0C" modified="2011-10-19" version="1" fragment="single">MTHGHDPPSHSPPSICGRGRRAGRFVRLHEAIAASRVAHGSGVGARAWLPPVVAEENVRPTELPRVRAEVHRGGQPKRDLLQLPSFTNIVFDTSSLLRMSAADFVNLLSSSVIHIPLVVQREFLLKSRLYRGFDARRCRSTLRCWISGSRTHNGLRLQQGRPRSIHDACTNATVSDDQILLFALHIQEEDPFRPLVVLTEDKFLTLKARNEKLVVHTVESYAASLTSQRGSRSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ8</accession>
    <name>F9WFQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002177">
        <property type="protein sequence ID" value="CCD16135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10860"/>
    <dbReference type="OMA" id="PLCECHA"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="805" mass="91326" checksum="8406257FCF1FC7D5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG22</accession>
    <name>F9WG22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002219">
        <property type="protein sequence ID" value="CCD16252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12000"/>
    <dbReference type="OrthoDB" id="1727949at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="20743" checksum="C67BF594E5B2D7A2" modified="2011-10-19" version="1">MLSLSFLKALNAFTVAAKCGVASACFFVHLASPELALGASLWLIFTRSPVASVPIDRITPQKPTWVSRSSPPNMPPCFPTAITWQQEVVAPDESVNKHFSLFANLLYPISSIISTSLISPSYISTSCMPSEIGSKPSSLTLCPLPRKKLPKLIFPAAHVFPMQKCPSSPLELIKTIIIFYSLPTNLSAVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG45</accession>
    <name>F9WG45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002228">
        <property type="protein sequence ID" value="CCD16277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12260"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395009" evidence="4">
        <location>
            <begin position="19"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="49"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="312" mass="35317" checksum="8A11EB0A38E0A73B" modified="2011-10-19" version="1">MKEFWVMLIVGVICMVNGDLREDHNKDEHDRLCRLLRTAVFYWKNKQGELSKGLQRALNLTIFGRESGGSLGNLKVKLPDVYGREPTENRTQWCGEPPNGTVRNDIPRWPGYSAPHDLLCLCTPGDQGWPLNDNEHASEKLCGQRREALHTESSEGWDSSGHGIDQIYATWNKITKPWLEDVGIEENLKDALKNFTSKLVRRSDKYGYKLGQGTPDGQNVCTGQRPYDLCAMYYNNTSPKPWWSEVEEALNEEHKQRAQEAQAHALSLNRNATVVGQNYTFNITNVTGDLNRTRSTSITTPVSWLPGAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGG9</accession>
    <name>F9WGG9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002269">
        <property type="protein sequence ID" value="CCD16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13290"/>
    <dbReference type="OrthoDB" id="1665971at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390304" evidence="1">
        <location>
            <begin position="24"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="406" mass="44713" checksum="8E8DE56899790C37" modified="2011-10-19" version="1">MLQAMKALGLLLMMHVFCSVVSCALSYYPKALHTETGGSICSLSRKLKEVIPWTQEQLDVLKKTRDAYASKFLDWQLHFHGSSECELNQSILEDIRTDLEKVNEEIKTLSGKAIRAGALAAKSAGRLDEFVTVFARARGDGPTFYEKSSFCFGYKGHPATRADLHDCFPEGTRFDIGEANLAKIPESTANKEEPNLTGVIENVNHSAVEAHFRKIHWEDIHADCNLIKGSSTGIVGSVNLGNPLWWGGGILTLGNNFNGVLERTKFNAGDIADASKGRETRALWTASPHTIPHIKKTLAAFQAFKDSAEKITQKFNEIDNIEKQIEPCLSNETMEQGPTQSCFQNAVNLNAELQAANALLARYHKEKGPLPSGSALILHPSVVKVWCLIAALLYSSFKLKIQPSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS1</accession>
    <name>F9WGS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 535</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002310">
        <property type="protein sequence ID" value="CCD16508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14260"/>
    <dbReference type="OrthoDB" id="85464at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="881" mass="98371" checksum="CEF289283F7C6B6B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY2</accession>
    <name>F9WGY2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_14840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002349">
        <property type="protein sequence ID" value="CCD16570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14840"/>
    <dbReference type="OMA" id="CHHADAG"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390322" evidence="9">
        <location>
            <begin position="21"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="47906" checksum="2478C28D58D0F5AD" modified="2011-10-19" version="1">MERMTALPLLVLGLCLNVYAEHTSVKLEVMKKVCNVSKTLKTMHKYVTKVSQEADLRLKDMETVQKLARIKVLKQKHDVSGCNKMAIFIHYSQQNKADMKDKINKLWATGLRLTASAGIAAGRLDEFVSIFMQAYSDKHYCVSSGEGKEKKQKAQMTDLKECYKDGTSGEFLGINDAENVDRIKENLRDDLNTLLQLDGGDPRHGFGEFTGCQLTMAETSYISNGTISKNVFWGDGIFGVRMGSKGKTGFKGSTRAELYKTDLVWEDKPLETIPTLKVFMEDFERFNQLYKDIVTIDKKMEEKWSLENINKEEFLHIVKSVGAFDMAALKKVKHLDVGAEADQDEQDDASFELVASLDEEQWIRYWDKILIEKSVLLGEIALCKTDSLSDSLRKNRTSAAAAAAAAAASTTTGGSSEHQESDGEEQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH95</accession>
    <name>F9WH95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 616</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002399">
        <property type="protein sequence ID" value="CCD16684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15910"/>
    <dbReference type="OMA" id="YEVERAW"/>
    <dbReference type="OrthoDB" id="1654621at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="805" mass="92195" checksum="3AE5B927E212E3F9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHF9</accession>
    <name>F9WHF9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 644</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002430">
        <property type="protein sequence ID" value="CCD16752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16550"/>
    <dbReference type="OrthoDB" id="380106at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="293" mass="32000" checksum="48A454B7D6143952" modified="2011-10-19" version="1">MWQRLFSRRGGSSRERSDVRSSSLNSEGARRTIVRRVFIVGSRLPYEDGPGVWGCTCEPRQPYSPKKEIKETPESCCSGRNTAAGYVKQGPEDALVVSPTRRRDAAIWFKSHGTLPQRKSIQRGASPRGKRTKGGGDASLPEGLVPSAVLDALKGIIRRGTPTARSGSRTRGSDAGTPQKKRNLSSSRKNACGGTPTYVEAFYKLDPQVAKRYGLIIASHEGPVLRNITPRTRGKCTAKTRGLPPRSTGDNFSCVRELSPISIPKERSNTPVRASFTVPHVLSTPGSKHHREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHL8</accession>
    <name>F9WHL8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002455">
        <property type="protein sequence ID" value="CCD16811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="15375" checksum="626560B3780395C9" modified="2011-10-19" version="1">MQKNSSNSEITTKNTLFRTKNKKTKKIFFLXFFSKILKKVIFHPGSAKKLFKPQNNPQKHFFPHKTQKREKNFFFVFFRQNFEKSVISPRECKKTFHTEKYPPKTLFSAQNTKSRKKFFFGFFSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN3</accession>
    <name>F9WHN3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002464">
        <property type="protein sequence ID" value="CCD16827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01860"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390350" evidence="5">
        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="40453" checksum="D3DD1CE7E17A0B90" modified="2011-10-19" version="1">MCGKVSVVMALLSVRFLVAEGYNDGVFKKLCDVLRKTRALYKLEKDNSTLKKSLEQAIYGTQTTALFNDDGGVEINQNCGGLKMRSYLCTFYGGAPAWHGKDGCLAESLFGTIMCVCTPGDSKSGIINFCGVDIKNYKGKTWSGKWLNSEEQNELIKKVLREVNEKCPEDGGHGLQGEAKLKDLKNSLDALKEKLKPTIGGNFFYFGENGWGGCSGTNGDNVCASYKGSMANKKNINIPWMQKIVTTLEDLSKTVETQARTLDATSSAHSTPEASGTLPESRENAENAKAAVQVKHSADEKNEDIGLLESEVENSGNPESSVVESSTARTTGENRTTTHHHLTEIPHITNNPNEDGFLITSKFSFILAALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR0</accession>
    <name>F9WHR0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002477">
        <property type="protein sequence ID" value="CCD16854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17390"/>
    <dbReference type="OrthoDB" id="1400935at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30202" checksum="B814229AF0F354F1" modified="2011-10-19" version="1">MTLTNFLHHIDSEIAALTRRVTTVGRQRESVEGNQSRRIRQLFECIERPWLLLESIPPPQLPNKPLDVFAKEMYVRQHGTSTSAWEEDALFLSNCRRNWRVLSVQQRKPYEIAARRNEQTRKELKKKINNGCTYFEKLCEQTKEWTAEMVRGELRRVASGKSHAAAPATSGRSTLEANKPTVKGAGRPRTAGKKPAVKSRAEKKDPEVEVLTFEPVVKKKPGAGKKIGRPAKAAAPKSRKAGGAIALPKTAKKAPQRQGAKKKPKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW8</accession>
    <name>F9WHW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002491">
        <property type="protein sequence ID" value="CCD16913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17960"/>
    <dbReference type="OMA" id="IFAPKGG"/>
    <dbReference type="OrthoDB" id="658146at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="599" mass="67583" checksum="1A3EBC8D1F7E401C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHZ2</accession>
    <name>F9WHZ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002503">
        <property type="protein sequence ID" value="CCD16937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18190"/>
    <dbReference type="OrthoDB" id="1402546at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="17211" checksum="17CB53782718462B" modified="2011-10-19" version="1" fragment="single">MSLRAQWNMKEGSFAGNAGGIDSPNDCSSASGIMDGLHLIPEQGVVDALQPVAHAGQAENSADGALSFDFIFHSMQPNDVNRDVNANCVASEGDPSRSTAFGGFCFDYACSDGAWPEGNAVATDAAAMGVGINNPTTQEAPFHLLLTDDPVVPCDEPLHPGFPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHZ7</accession>
    <name>F9WHZ7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_18240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002503">
        <property type="protein sequence ID" value="CCD16942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18240"/>
    <dbReference type="OMA" id="FLVIPTK"/>
    <dbReference type="OrthoDB" id="883398at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="3">
        <location>
            <begin position="210"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37535" checksum="9D569E9F0122C519" modified="2011-10-19" version="1">MKGTHPVLVVPCRRGGIPYLTPEQARDILEEEERVVSLCIFDAHEYRTVCASTQRGFTEFCGLADFKLILTVRSSLVGMHASAPASDTAVSGDHGKGRLSFHSGQWLELVTSLRPTMAVTLYDSVPLHELNPRRRKTTSNRSLKWANAADSLQHTLGCELIKPYGTTGEKATYVYAGNLCQNELIEQYYCHLREAVESHQVMAPAMSVGAVLMALMAGVTLIECPLPWVLAERGVALTLNLKPVPGETPRRYESQIDLNDPYFAVDIGPLSPSCVCYTCKRHNRAYLHHLLTVQEMNSDILLVIHNLSSMVQLVRQYRRSSAEDRHTLLSWIFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIA4</accession>
    <name>F9WIA4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002553">
        <property type="protein sequence ID" value="CCD17049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19080"/>
    <dbReference type="OrthoDB" id="275882at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="666" mass="73469" checksum="E39248121F240258" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC0</accession>
    <name>F9WIC0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002565">
        <property type="protein sequence ID" value="CCD17066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02130"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="21825" checksum="DFC57CC6FE50E5A4" modified="2011-10-19" version="1">MTRVKDNMLVSKEEGCTSKIEMFGIQAFTSSHVVSEIARHLKYLPRGGETERSRSSVLARVCASGRVPTSVHYFSSADTPVEMVAECLYKPAEKNFPVVGGFFLVDAVGEGVLHSEGTEVLTRTIVLLQMSGARDHHTTTGKVDVFRKRMAKSFTNWREMESRLSYEIIYLQHADSTALTGRQRCTRSGVADDAGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF8</accession>
    <name>F9WIF8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19570"/>
    <dbReference type="OrthoDB" id="1715561at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18934" checksum="62D4FB172084BA59" modified="2011-10-19" version="1">MLKEAYAVAVPESLGLTRVRTASHPPWTTSSTVDNVLLHELKDKRRIHLYHFPLDYGWDSPPSVGLEVTLGAFLRDPRDTVVEEPVRQQILQHMPGMLSRLYGDLGLDLRNLLARGIRTLEDWAHHGWYMVDLSALSEVILEQAFLEALGQPERMLLEEEGRDRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIM8</accession>
    <name>F9WIM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002618">
        <property type="protein sequence ID" value="CCD17176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20210"/>
    <dbReference type="OrthoDB" id="1718120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="19543" checksum="3442B2AB817EA7AF" modified="2011-10-19" version="1">MLSKQQTECGECYQSSKQNVKNAIKAANRMWRMLSKQQTECGECYQSSKQNVKNAIKAANRMWRMLSKQQTECGECYQSSKQNVENTIKAASRMWRTLSKQQTECEEHYQSSKQNVKNAIXAANRMWRTLSKQQAECGEHYQSSKQNEVNAIKATKGMWRTLSKQQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIN5</accession>
    <name>F9WIN5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_02250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002620">
        <property type="protein sequence ID" value="CCD17183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02250"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="279" mass="31344" checksum="0004F9DCE242D2D2" modified="2011-10-19" version="1">MHRSFEEGRMLRTHRRVLLDHVRPAPKHTKLDRLGESLLAQFRAGTSKPFGWLHRVLTRKTDRLECRWCKVKDIGGDAVEGHTLAKSAVDSANAQEFGIATRQSDPIICPLCHMVCARRQAGVVHLVKIHGLERDYALAMTKKARRAALTYKNGCTCHVCGDAFERRGLLVEHMAQHPPDGILAEEKRPKRAREGDEADDGKAFKCCWCAKRYTVYARLRKHMIQKHPEKQLKSDDIPVEQEASSDSDGEPVQENRISYARSVIGSSKARHGSPGPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ29</accession>
    <name>F9WJ29_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 864</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002674">
        <property type="protein sequence ID" value="CCD17330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21580"/>
    <dbReference type="OMA" id="YTMETLF"/>
    <dbReference type="OrthoDB" id="1288281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="34130" checksum="B0E53BD9036D3A2D" modified="2011-10-19" version="1">MSQCSVGESQCMFSFSSGPFSAVALDLDGTILNNDHNVSTLTKATLYDLSSCGVHIIIVTGRPRQGVKNIEDSLSEYFFQSSRAVDCSTCTARVRGFHLISSNGARIFSPSGNLIYQQNIDSDVVRSIYERFAGGELADELLVSVHQTDAWWISKALPEEWLLKKYGSLPRVRKDVLSEFPVEGVGKICLRSHDKQLLDRYQKEADMMFGYSVITVMTSNHGLDIMARGVSKASGLKLVGEILNFDLSRDVIAFGDSLNDKDMLSTVAKGCIMRNGRDELKELLPHVEVIGGNTEDGVAQKLREVFMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ70</accession>
    <name>F9WJ70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 878</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002690">
        <property type="protein sequence ID" value="CCD17373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21960"/>
    <dbReference type="OMA" id="ESHHTSE"/>
    <dbReference type="OrthoDB" id="625466at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="358" mass="41343" checksum="49C621BB6F88F0E6" modified="2011-10-19" version="1">MFTRTFQGSILNAEGHNLQKEGVAPAPHVMTFYHSYIDPENAKRKRPVVDVSAPYNPLDETHQIRKLGVQKLPLGFLSLNSFIGAIEEVPYTDSMHTYECVKWAMGGLNVWFINWFVARGANSYAPVGHPRTRFAWNIAFVMGVLRTNMAGIVGIGGYFYAYEWLYTHGPPPFRIRDPAPNAWRRAWDEGQSCYAARAAACIFPPLGYAIFMGRWKKTAFWFVTCLCFSMQYEYSRKYILPGMRLFYSFEAKRELQRQANWGSLAPVLEHRVDPDTNRNESVAQSPYFRITSGSLQDTIWANATHENLPFRRYGTQLRNPYYNWQKARQGYNSKAHRNKNDLWELPNVLKSHSTLHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJJ4</accession>
    <name>F9WJJ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 918</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002734">
        <property type="protein sequence ID" value="CCD17499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23160"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="21213" checksum="62F31BF2580F8CF0" modified="2011-10-19" version="1" fragment="single">MYATHGGARHIGNRKEQSDGVQEADSRGLRDAIGPDAVRRLEKALSAARRVEENPVRVMPRSAEVINGLYDSVYNARWRCVITGKMYKNQPFGMKLLNAKTEVPCLWSRGDVDTTPELGQSYDIEEVLVRSEKVPVVAVLSSALGWPSRMHASQQPLKDLPAPQGESGDYTHLYIRKEMMRVWYIIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJJ9</accession>
    <name>F9WJJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 921</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002737">
        <property type="protein sequence ID" value="CCD17504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23210"/>
    <dbReference type="OrthoDB" id="1701528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19594" checksum="DB1A4B1CCB1546A2" modified="2011-10-19" version="1">MERDVVEVLLEGVTSPDHVNLYWFLRPVLAGLPVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTETWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVWVDPAPAFIQVPYSTVGYLVPIPLSPGDWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK4</accession>
    <name>F9WJK4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein TCIL3000_11_8590</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_23260</name>
        <name evidence="3" type="ORF">TCIL3000_11_8590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002740">
        <property type="protein sequence ID" value="CCD17509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.8590"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23260"/>
    <dbReference type="OMA" id="VNTISFR"/>
    <dbReference type="OrthoDB" id="463053at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC95405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="32167" checksum="92BB54F4C268589D" modified="2011-10-19" version="1">MKRCAAKRDAQSEDRGDHSVQEDFAAASISDRRIRINVGGEYITTLARTLCSEPSLLSEWVKNDFAGIPRDSLGNPFIDRDPENFRQVINYLRGYGLPASTERIIFLAEDAEYYKIDKLMALINPQTQWKFLSGPGISENQKEFSTENILATCGTEPLPPEGRAVFSLRVEKCDIVTIGLIGAKNVRHNVPLEKQVNTISFRNSGDLVRHLSCSCTFKQSTGYKSHDIVEVHVSLKPDAPAQVNFYCNGGKVHETDWPSPVPPLRFAVSLHGASVVIIEKCTTVDVGESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK35</accession>
    <name>F9WK35_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 983</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_24820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002806">
        <property type="protein sequence ID" value="CCD17696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24820"/>
    <dbReference type="OrthoDB" id="1716049at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23350" checksum="1067B861AB7577F7" modified="2011-10-19" version="1">MEPYRPRTYSCKASIPRLTCDSRGGERKRGRHRKCSPKGVDNEALKQNDNEKSDTLTVDKGPSLAAFSLLLACASVFTVVLIVPAPLQLLLHVSSIHFCVLLLCFFLGVAVHDPVKGSNMKRNNIRNTFVDWLCVECLSLNFTMRSKCFVCRAPYDAKRCLAVFSSRQQNDQSVYDPDHSAYMQEVELNFSSSPTQLKRVKYNKRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W394</accession>
    <name>F9W394_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000376">
        <property type="protein sequence ID" value="CCD11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25730"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="23467" checksum="AA232E31AD6B0649" modified="2011-10-19" version="1">MAPSCARKRKPIDWNAGGTAGSIESRTTSRVQPVKATTEENSEHSQASHVAARQGDTIIFPLCNVASAHCQAGVVYRMKVHGIDGERVLVLTNVGRNASHECNGDYDVFLPHVAPLPERGCWPFSPAVSHASPNSSPMYTASKRNGEEEEGENADSVKLKRLWCCKKHSSYGRLKRHVLAKHPYKRDSQKRAVSITGLRILVRVKLTKMRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G2</accession>
    <name>F9W3G2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000406">
        <property type="protein sequence ID" value="CCD11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15433" checksum="42D328F5AAF1198F" modified="2011-10-19" version="1">MRMTGGVRDGEGSRCWRIGGLAAVVVVQSHSVLHARSSYLTPTASRYVLIQYLKSSSAVFRATFTACGSCLSEHLCGIFALSCRARGLGKVPRCETRHFLFNVPLVPLKKVFSLVLAARTTAPLEIFRGEYIQWLPKINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L9</accession>
    <name>F9W3L9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1075</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000435">
        <property type="protein sequence ID" value="CCD11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26930"/>
    <dbReference type="OrthoDB" id="1707867at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="21247" checksum="6E517B6305F1FF19" modified="2011-10-19" version="1">MLWSFLYFFRDFGVSVFFCFVELSVSLFFNLIMFLDFFSKLGLPVLLFTFLRVQNTDTITSSATATGFHYPYLALSPFPFFLCEVFQNRFQIVATSTLQTTRTILIHVFFVSSSLYPFLLHPNQYTSSFARCPRLPNYFDFFRIVFRSCQTSLVTLSDHACRGKSGCVYRSLWVSTLPRDGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P1</accession>
    <name>F9W3P1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000446">
        <property type="protein sequence ID" value="CCD11764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27110"/>
    <dbReference type="OMA" id="WIEYAES"/>
    <dbReference type="OrthoDB" id="1623015at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005678969" evidence="2">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19478" checksum="61C8828DC38337DE" modified="2011-10-19" version="1">MGPGSRFALLFLALMVCGVRTGNGFLNRRQFCGDVKTRVNAVGVRFQGVWIEYAESVYRTRRVKESCSFSGALGSDSVFEKIRLIGEYYDALNDIGAEISQNENQVHELVVSAGKQCGFWLSFTPISAHVRSETTHKLDHAEAIIRKMEELSLKAKQYENEAQMHKCELDSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Q9</accession>
    <name>F9W3Q9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1093</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_27270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000455">
        <property type="protein sequence ID" value="CCD11782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27270"/>
    <dbReference type="OMA" id="ECSEAHE"/>
    <dbReference type="OrthoDB" id="514396at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin_C" evidence="6">
        <location>
            <begin position="54"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="28895" checksum="8FD34296750B82E4" modified="2011-10-19" version="1">MATRAGEIRKKKKKKKNLTRRNLDIERPTYTNLNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVISAEKAYHEQLSVSEISNAVFEPASMMTKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWSPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADMDGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W404</accession>
    <name>F9W404_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000500">
        <property type="protein sequence ID" value="CCD11887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15566" checksum="8788CF0E8AB65DBA" modified="2011-10-19" version="1">MNFDHAPQSSPLGRRALRKLHEICPMERQSVVGLEVAALHFLHTATIARLRSTNFLLAQGGASTLISIDRSWGVASRLGLLTSRYRGARCKADRKCRSFVGCWCGRTCLVVEVRRLDFSFRSCWKPCLLQAFGNRGSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W425</accession>
    <name>F9W425_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_28440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000507">
        <property type="protein sequence ID" value="CCD11908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28440"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="279" mass="33359" checksum="E22BE23C4A9CCA38" modified="2011-10-19" version="1">MTDVSDETKNDVGTNNEVDRLKKQPVDWENLVVEWRKREDQLSRRKRLYEEQAGDMNWVREAYMVFLELAEKVARLLNDSDGKAEKGSLVELEEKMKEGLRKWPEYLETKKNHWKSRLEEQKKETGGDAVEEELREQEDEADELEEELETIERKIKKVIDPVFLFESRPYVCPYCDRKYVSVGWLKRHVRREHAGQTVPDIDEDRVRFKCPHCCKTYKTQGWLNRHLEEKHAEKEDPGEPESDSDEDCVKLRCPYCIKTYTKMGWLRRHLQEEHAKDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W482</accession>
    <name>F9W482_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000526">
        <property type="protein sequence ID" value="CCD11970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00240"/>
    <dbReference type="OrthoDB" id="1691677at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="26071" checksum="BE8FEF5C5253F3A4" modified="2011-10-19" version="1">MLERLHDNAIKDVRYLVGDGIITLLDWALRGASTLLDHVPRDILHEAVREASKHPRSPITSGSTSMQRRNEESDKLTYQVTGTPSTQRQQGRTRDNELEEILQKACKSWEDVRLVDFLAQEYGKTHEACNPNATLAASLENPSHYIEKGAECEEVVEKLPEKLHHLKGCIFRDVTFLRAIGITIRGYWAHHMFYHEMLTPVTNCTLLRAYGSPLDQGTYMEDKQTVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4E7</accession>
    <name>F9W4E7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_29580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000546">
        <property type="protein sequence ID" value="CCD12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="YTNAFPA"/>
    <dbReference type="OrthoDB" id="1483558at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14337" checksum="660CD4021D4BC7D0" modified="2011-10-19" version="1">MLTNRFKNGEERIIGIIGDEDTVTGFLLAGVGDNRRILTQAAGEKKCTVQPNYFVVSASTPLADIEDAFTKMSTNPSIGVIIICQHIANEIRHLIEGLSVQIPCVLEIPNKGGVYDASKDSVLGKINRALGCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P7</accession>
    <name>F9W4P7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000589">
        <property type="protein sequence ID" value="CCD12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30550"/>
    <dbReference type="OrthoDB" id="298504at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="316" mass="35504" checksum="129E0C471648741A" modified="2011-10-19" version="1" fragment="single">MSIWKKWQLSTTEECRASRRPLLLRFVSACPACQDLIWLGKSPAKCFSSFWANIFSLGDRERDFFVQCVELVCYGVGMHPTPAVNSAIERLAHGHLALKDHASHLCGTKLCAEVLCDVVLLPDGNPCTGWFPDKYDFEYYRTTVEVLEDRWNTSSGTLWALKSRNTKDEMNAKTMSNRQDNVLCESREFPPERVNNFVVRYTRFLQSSGIATEESVSGIDHLSLSLLDEPMEGRANSLLHSLGDVFAAEKAKVGRAAVYPVICRIFSRLLAIQMRERNACPESVWTLGAELSSLPVGNHPVAQVSQKYVTDLLGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W584</accession>
    <name>F9W584_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1289</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000674">
        <property type="protein sequence ID" value="CCD12332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32240"/>
    <dbReference type="OrthoDB" id="258915at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="348" mass="38239" checksum="E56A01984721818B" modified="2011-10-19" version="1" fragment="single">MAQGHIGEGGVLSALREAVSSGQASSIRDVDPQVVAAYDTTVLPELTRLCSSIGACQNNALMNAAWKLLLAVASLPDISAVIYGRILHFMFLQLREHVLSHDWSDAKQSRLSAVVASYLVSAVRANPFHAACNGEFVNSLLELHITTIFTVTTSDREESARRFYQDIEVRLLAIVEAMGSSLDHHESQVDNNWKQLLMDCLRDAPSEVTDALGDVVNTVSISAVAAMTAMLAACRSLVMSLGEPASLEWLLETLLLWLPDMSLVLLEGGGTTPLQGRVSQLSREVPHEVYHTDYRCESDTSELPKELDLDTQLLLLLRRATRRCVELSRRSKRNLSKSGEERGDSCCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S2</accession>
    <name>F9W5S2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_33970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000757">
        <property type="protein sequence ID" value="CCD12525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33970"/>
    <dbReference type="OrthoDB" id="1712167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389827" evidence="5">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="87"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="19969" checksum="FF36A1D0DB9A825E" modified="2011-10-19" version="1" fragment="single">MACFVNGITIFVLVGSVVSGQLEIDRDDNIEPFSLLCRIYNVAKNPPINHIDLEEPFKIVQEITDLNASLVNDKRYNETEMGNGVEAKTNSASTKESVVAQLSLNQITQRAHKILEDIEKLNAEEKIEEVKAEFNKVIFGENGNESDLCRATVKDVGNRATACGNPGDGNKGNSAGNNLAVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S5</accession>
    <name>F9W5S5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000760">
        <property type="protein sequence ID" value="CCD12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17420" checksum="F57BE1513DF0E099" modified="2011-10-19" version="1">MNQLTKASTDMQETVRYAEESESTLHQLQLLEYNALLFYKEAKYSAHLSHIVSFNAIRSNESYEENSHDKSNETPKETETNSSEEERLEDEEEEESKDGTWKGGPPWRGFFFLWLFNDKIGKIRTPVCVWIRTGELLCHKRLHFSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W623</accession>
    <name>F9W623_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1415</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000813">
        <property type="protein sequence ID" value="CCD12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34880"/>
    <dbReference type="OrthoDB" id="1124715at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="583" mass="65453" checksum="3FB0528E9B537724" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W629</accession>
    <name>F9W629_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VSG_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_34940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000816">
        <property type="protein sequence ID" value="CCD12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="17"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13211" checksum="B51D6EF236E34FB3" modified="2011-10-19" version="1">MDSRRLFVLXHAKAIKKDNGCNGKIDGVCVNYWAVSNLGIGIMWQNYMLEAQKHLQAMDKHIKKAQKLSTMFKKLKESAEESHRSSAHGSMLWPIEEGSQRNTLHDFFIFFACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W654</accession>
    <name>F9W654_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000823">
        <property type="protein sequence ID" value="CCD12658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35180"/>
    <dbReference type="OrthoDB" id="1281266at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="PTHR10424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17706" checksum="5F30AB4BFEAE5898" modified="2011-10-19" version="1">MDVDLRTIEQSITKLEESLTSLSEVVLQNRRGLDLLFLKEGGLCAALKEECCFYVDHSGVIKDSMAKLRERLDIRKRERESQQGCFESWFNKSPWLTTLLSTIAGPLITLMLLLTFGPCILNKLVAFIRERINAVQVMVLRQQYRVLQEVENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W686</accession>
    <name>F9W686_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000833">
        <property type="protein sequence ID" value="CCD12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35500"/>
    <dbReference type="OrthoDB" id="1703870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21456" checksum="FCCC9659E29A2766" modified="2011-10-19" version="1">MLSLPREAPKVNSLESHFNSAVVKDVELFFADLCKGICLLPFGQWTPIAHKSLCTQWSGACSAFTKFQLAASVVSSLTLFPFIMLRDVSFSALLNMHISTTLLSYWFTFSNFLFQVFQFPCPERCQSISLLYQHPCRGANCRQNGAIQLASFPRKFSNHSFNFLTQVCRNIPSSRYSTQRVGPCLRLCTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W698</accession>
    <name>F9W698_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_35600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000841">
        <property type="protein sequence ID" value="CCD12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35600"/>
    <dbReference type="OMA" id="MPETTEP"/>
    <dbReference type="OrthoDB" id="727241at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="957"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="573"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="625"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="654"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="732"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1215" mass="133163" checksum="CD8C840C41CF2B07" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P9</accession>
    <name>F9W6P9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000907">
        <property type="protein sequence ID" value="CCD12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36970"/>
    <dbReference type="OrthoDB" id="1706872at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23635" checksum="14D06A6140304982" modified="2011-10-19" version="1">MRTPVRCCGMLGTFHNLLEVNHFSGLPNGRIGIAFLFSFCCGGVSFRGLCFRRQHGAQLVFSQDVTNVIVRCEAVERHRLRRFTLFLRMGTDAYVPIICGNRMRGYAEGRCRMVEEPLLIPLLLQLRTNLVIFRVVTVLNILRFLPPIGGVQLCLGASEKKILTDVRASSLPSVEATVLHPLCCECETQCIRTIDDVYSVPFFFCFTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W700</accession>
    <name>F9W700_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_37770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000956">
        <property type="protein sequence ID" value="CCD12958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37770"/>
    <dbReference type="OMA" id="FRRICAY"/>
    <dbReference type="OrthoDB" id="1507446at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="PTHR13100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="zf-LYAR" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="249" mass="27555" checksum="284F8D1207E35EB0" modified="2011-10-19" version="1">MLVKGKRIRKRIGVGFEHIAPLLSHPLCIFRRICAYSMVSFTCSVCQDVVKKPKVIGHANGCRGASFVCVDCMEVFDLETVRGHTSCVTEVEKYQGRWQRNGSATERKGHMGVTRAREVSSDSNSDDESWVRQKKAAPTHGVVVPPSRNGDGCRKKQPRLESFALPPSVSEEVAEYTVPGFVLGSSEEVAKVARWVLEDAAPESLSVREVARRLVGYYEARIARQLRGTVESLIRRGELRLEGGVVVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W778</accession>
    <name>F9W778_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000993">
        <property type="protein sequence ID" value="CCD13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38590"/>
    <dbReference type="OMA" id="TRQICST"/>
    <dbReference type="OrthoDB" id="1733659at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="20280" checksum="D53480AEB35B565B" modified="2011-10-19" version="1">MNIGTGYHRVPPLTQPLVVGEPQKLRKSRGEKKKKGLSLTHTHDVKGRRANERVGAEKLMGAREELMKQLSNTLSEIGRCSSSNGVAVEARLLGAVADYIESGAEAESTLRSLRDALLRMGDGSAEQAAVRVKKEDDDITKDEKKEEGDTRQICSTPVMMTRKEMGMQRAQQLLSDTLLARYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7G0</accession>
    <name>F9W7G0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_39080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 3">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001023">
        <property type="protein sequence ID" value="CCD13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39080"/>
    <dbReference type="OMA" id="TTIWYRE"/>
    <dbReference type="OrthoDB" id="454386at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="ThiF" evidence="4">
        <location>
            <begin position="6"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="616" mass="69453" checksum="0E297FDB5CD8AAC8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S5</accession>
    <name>F9W7S5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1648</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001073">
        <property type="protein sequence ID" value="CCD13247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40160"/>
    <dbReference type="OrthoDB" id="1721644at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="19054" checksum="C0F2032D8713B7B7" modified="2011-10-19" version="1">MWRTLSKQQTECGEHYQSHKQNVKNAIKATNRMWRTLSKQQTECEECYQSSKQNVENTIKAANRMWRMLSKQQTECEECYQSSKQNVKNAIKAANRMWRTLSKQQTECEECYQSNKQNVENAIKAANRMWRMLSKQQTECGEHYQSSKQNVENAIKAANRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y0</accession>
    <name>F9W7Y0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1673</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001101">
        <property type="protein sequence ID" value="CCD13302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40690"/>
    <dbReference type="OMA" id="CAIYNIS"/>
    <dbReference type="OrthoDB" id="1449637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30183" checksum="4268C74181983A3C" modified="2011-10-19" version="1">MIHKPQQRKGCEYGSVTRVCNWFTAVIAFFKVFFVPPLPSICCFSPPHSSLTCYFRRRIFVAMSRQSGQQHAMNALGNQFTCAVILSSAARHFSNDANNFWLLLQTDDGALSPETIVESIHRFCIAHDMKFVNCGSDAATLVHEREAHVALVRCSDATEITQQLLQLGGNPSVITLEIFYSEATTWNPANVMPSDEWQWLRPTPSCLAEMRHSSSGTCSTVASLPATMRCAKPVIRAQLPALGPGSVPWSAAVTLEGMMREVGYKVGCLSKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y2</accession>
    <name>F9W7Y2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001104">
        <property type="protein sequence ID" value="CCD13304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40710"/>
    <dbReference type="OrthoDB" id="200769at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="35366" checksum="27EDDC99E960E99B" modified="2011-10-19" version="1" fragment="single">MYAGAFVSYLQFLQKDVWWTVMYVIFLIWMYLFHAPFRVNSVWRTDWYAQVTKVLQIWIGVDIFLFHACPRFFESKQFVRDVANTTDEDAVATLFFPIFSTTTLIILYLHNSASRWGLGVTYGSNVTITVLNSLLLSLFSTMHFAYGLQILDFERSSWLTSAVGVVFPSSEQSLLPTLLLLCVINILFMALDYRYKRSCGFDPLRGLLWCEVCDHGVVHEEVVAVSETDDDWRKSEPKPRQVVKDEQLWLTSDADGRKLNFALSGEEMRQLSVLHPVNRPGMVPWFSTFIAGTALQSVIGNSLNFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W807</accession>
    <name>F9W807_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001116">
        <property type="protein sequence ID" value="CCD13331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14520" checksum="6D7851C2F5C8595E" modified="2011-10-19" version="1">METPVEAILESARDDWGAISATTFFSIYYVHGCVLVPNSPLTLKQYLKDWRRFVPNSVNGKRFRYRLRLMDALMQRHLDQDMARLRAAKVVTLEDWQREGGRVEIGPMARALLTEALLQAVLPSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W853</accession>
    <name>F9W853_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1707</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001138">
        <property type="protein sequence ID" value="CCD13380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41370"/>
    <dbReference type="OMA" id="VGLTICH"/>
    <dbReference type="OrthoDB" id="1402758at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="586" mass="66115" checksum="4B817EA0BD358B43" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W855</accession>
    <name>F9W855_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001139">
        <property type="protein sequence ID" value="CCD13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41390"/>
    <dbReference type="OMA" id="CANQDPS"/>
    <dbReference type="OrthoDB" id="1188455at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="SSF47576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="442" mass="49454" checksum="1A8AF42E11364B13" modified="2011-10-19" version="1">MFKPFHFCFREAILIKVSQEVMPVFLTDTQLSGRATLLSWINSVCSTQYPSVVSLRDGVAYCIIVDAASRHVAENCSGLAIPGVAAFRSRSRRSSQLLGRLDWDITQVTCANQDPSLDCLQDRAQCERNLQILQKMLYECLPREFSLEVDVPRLAAGKLQDHVQLLRRMQHNVNRLLTAFSRTTLERRLRSTDGSGCVEGVKMTRAMLLQRRAAQKQLRRPTPRRNDKEDIDTHDHGQRYVEAESGSEVNRKGDCGMRPPVAPSEHVSPAQVSPGSQPSCGIGPRMERASEGYFIQPTSYNGFKTTGGSSVVVKRPRDFSHASRGMFHEFLGELVRDIELYETLVLASQGRHQRCLLGCGEGKGEDVGAMEPHIVDVLPKEAPIICLEKLGLLSEKRDKLWQTLSVIQNTIIRFASNMSEEDWDSMSAAPLIKTIKSVLSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W883</accession>
    <name>F9W883_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1716</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001149">
        <property type="protein sequence ID" value="CCD13411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41620"/>
    <dbReference type="OrthoDB" id="1694771at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="26598" checksum="F87A54E1508A6953" modified="2011-10-19" version="1">MLLLCNLVPSASSLLLSCSFPILLSFTFSLYFDIINSIDAFGIVRRRQVSNREYGGGCFFLFPIWKVSPVENCNKDVCNNLCDITKRASSFLRLQEWNENVKHDLEEAIYGKRGRAQFKKDGKVDFGEDCDLFDSGRSQLCSFKGRGNQGTGRNGCFADNLFGAFLCTPGSGDARTLCGLGKVGKGAVWSGFAGAGHEKVLFNKVLEKVKEQCTGELPNVLNNDNKLNDLKKPLRRLRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W897</accession>
    <name>F9W897_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1718</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41780"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="11" mass="1457" checksum="7886F5FEC72B1864" modified="2011-10-19" version="1" fragment="single">KYFRGELFIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8G6</accession>
    <name>F9W8G6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_42440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42440"/>
    <dbReference type="OMA" id="NQQIPHN"/>
    <dbReference type="OrthoDB" id="1239434at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_L13e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_L13e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="PTHR11722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="25207" checksum="C7728F6DF39E7F48" modified="2011-10-19" version="1">MPKGNNAIPHVHQRKHWNPCSSQKGNIKVFFNQPAQKQRRRRLRLLKAKKIFPRPLKALRPQVNCPTVRYNMKRRLGRGFTLEELKAAGLNRHYARTIGIRVDSRRKNKSEEGMNINVQRLKTYMSKLVLFPLSRKTTQKGEASEAEMKAARQDRTRFGTAAVGGLVKPSAEAPRKVTAEEATKNVYKFLKKNHSAVRFLRARNRRAARKEAKENEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8I3</accession>
    <name>F9W8I3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42610"/>
    <dbReference type="OMA" id="ACRIISF"/>
    <dbReference type="OrthoDB" id="915829at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="107"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="305" mass="34669" checksum="5050DB3663E9BC30" modified="2011-10-19" version="1">MSVLGVLLLALIFGVFWYLLRERRFPVVVMRVWFSISILATVTTVYIVCIPIRVARRMKWITKRRSEEIGCWFSCLVMGKVLRFLTPHIHIKVMEGSLDPHGLQQANVTCSCHTSFFDTLLFLEVMSPSYVSNSRALAKHTLWELPLLGKVIDVCGHFPIYFTSSSENSFSVDKEKQAQVKVATDEFINSGGNLCLFPEGALNRTPEKLKDFRHGTFTMILQHNSRLYYVVHNGSHEVWPAKLTGLPGSPADVYIYIGEHKYDAATSTAEQLSVELRGVMQKHVDQILELRMQSKRSTGEGRKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8N8</accession>
    <name>F9W8N8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1755</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001192">
        <property type="protein sequence ID" value="CCD13573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43150"/>
    <dbReference type="OrthoDB" id="1687410at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="27599" checksum="89E32064425E5A60" modified="2011-10-19" version="1">MEKLPRFLLRNALETAMYVPTTPFVPPCPIRHANGPDAESGQEEDRASSTNDSRGGDAARLDGSGPPPGPLILKWSTRIQEVLRAGCWSWELVPLADFLTEEWSFHVDEGNRPTASLAAFLKVAARYVSHEKRREDILLAMSHKVENLNNLVIRDYQYVHHVGVHTLDQWDGMQETFRLEVRWVTSTILDAACEKIWVKKHRRGKPRGNKKTRITPPTPMLIYIFACWLLFFITYVYERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R6</accession>
    <name>F9W8R6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001206">
        <property type="protein sequence ID" value="CCD13602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43410"/>
    <dbReference type="OrthoDB" id="1722558at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20473" checksum="235E6B6DA6E69423" modified="2011-10-19" version="1">MHRSVVSVSTRPALPHRQTCKIRRYVNGSVVGHKDRHTSGEGKKNIHLDGSKQKEKEKRTKEGNGAENAGRAKYIHLTRETSKEENKCARRRTGSKNPLIASWRAPPTHSLTCLPCWLKEEGGRQQRFRRKQSNFKRERRGKKGIAKVVGRRKKRKKHKTVASPTGAGAHNPVHASLHICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8T4</accession>
    <name>F9W8T4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1775</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001214">
        <property type="protein sequence ID" value="CCD13620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M20.A18"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43580"/>
    <dbReference type="OrthoDB" id="733473at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="211" mass="23622" checksum="8EF4DFF54FCBC61C" modified="2011-10-19" version="1" fragment="single">MATDWTAVHKSIADDWDKSIVSTISAYIEVPNQSPHYDPEWATNGLMQKAMSIITDWVKKQPIKGMKYEVFNEEKLTPFLIIEIDGTEPCANTLLMYGHMDKQPPLLPWDEGLHPYKPVYRDGKLYGRGGADDGYAVFSALTSVAALQKHNIPHGKVVVIIEASEESGSMDLPFYLNKCRDRIGNVDLLICLDSGAMSYDQLWLTTALRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8U0</accession>
    <name>F9W8U0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1778</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001217">
        <property type="protein sequence ID" value="CCD13626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43640"/>
    <dbReference type="OMA" id="ATAAMEW"/>
    <dbReference type="OrthoDB" id="1068041at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025487">
        <property type="entry name" value="DUF4379"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14311">
        <property type="entry name" value="DUF4379"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4379" evidence="2">
        <location>
            <begin position="82"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="670" mass="72241" checksum="4371AEA101F6D7F0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8X9</accession>
    <name>F9W8X9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1797</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001238">
        <property type="protein sequence ID" value="CCD13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44010"/>
    <dbReference type="OMA" id="EAMAHFK"/>
    <dbReference type="OrthoDB" id="1260827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19392" checksum="DD661EB0B4A3FE2C" modified="2011-10-19" version="1">MPRPFGTWAPATTLAEFRARVPGFRNFKLVWAHKGRREVYYHPDALAHFKDHQQYKDAVDTIRAMRVSDRFFGEGVKYPRHPFIKMAVILAMHGTLTYTCLRYYYGTHVPANNPTWRKIVNKEWEEAINNSPWDHMSHVWQYSDQYASSIGEAVSPGRRKFYIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W932</accession>
    <name>F9W932_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001255">
        <property type="protein sequence ID" value="CCD13722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CACNPVA"/>
    <dbReference type="OrthoDB" id="741812at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="PTHR31005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="334"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="464" mass="51324" checksum="1060C6DB75F1ED4E" modified="2011-10-19" version="1" fragment="single">MSAEFGDVNERDAEIIRTDSKVDSVTIYKGRAQVQRSAQVKLPPLNNSQSTPGTPANTPATSMDAVDQLGGTNTVEASGHVRGGDCEGRRTEGGAKSRMTSLIEGKYDDEREVHIYFAMPASFDRDSVQVGFDELTADRVVLRRVFFETVEGLQADGSGAAEEERCRQRLEEDLSALQRRSQELAEQRELNRLQQEQLDDETRLAMHLFNCACNPVADGLGEAMTLDFWKAQINGVEERTQHQTTELRRLQKKYALLEKEECDVDRQIELMKRRRYKGPEVSARNKEQPVPTVAGTTSTPSMPQSYYSPLGSKHYFCCIVLKVRCDVPQSTVYVTYATYEASWRCQYEIDLDSQKSAITLHCNAVVKGGVENFEDVALTLSSAVPRENNEKMTKLKPWRLKIAGSEAACSTASDGGRGPRPSEPVGSCRSRSSSSSSSSSGDEGVDLPDKPWNVHGYAEGIGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W964</accession>
    <name>F9W964_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_03730</name>
        <name evidence="8" type="ORF">TCIL3000_0_44610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000939">
        <property type="protein sequence ID" value="CCD12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001272">
        <property type="protein sequence ID" value="CCD13754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44610"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007659133" evidence="5">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37394" checksum="31EBFACB54F75C6E" modified="2011-10-19" version="1">MFLVIVGMMMMALSGSSLGTGTSEHHNHNEDHHDTLCGLLGAAVRKWKRTRNPTTKKVLAQAIFGNESGGNLNTLLAGLPETHHKPGNRHNWCGSCAYGGDHYPGKSIPHDMLCMCTVGEGGFPFLAYSDKPETKLCGKSAADLGCKNQQDSGNGCHSNQHWWTTSTKSHNGNGEAKVHLNVTWEKVVKPCLQGGHIGRAKKTLLEKLNVGEYSSPRWGWGHTNCGGDHSDVCVSYGHQCHDNPKSPQWWQELYEALTTTEDTHAKGKSTRSTRKRTRRNTGGSTAPEEEENDSEEDEPEDTGTESTNNHNRQLPLLSHQQSGTSLTQPHSWLLSGVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9E3</accession>
    <name>F9W9E3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1853</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001301">
        <property type="protein sequence ID" value="CCD13843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45340"/>
    <dbReference type="OrthoDB" id="1699194at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390032" evidence="2">
        <location>
            <begin position="20"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="27707" checksum="E9032C3035B17BDB" modified="2011-10-19" version="1">MRVMYFIILLFIFVWQIQRGFLVCCYKAAQHLEKKNYFSLWVNGVGVSAVKFERIWHELGVQHLIIFFPLPFNFCFGLRHIYRGFFFLSLLLLRFCTNFCYLAAAPFRSPPRTDCSFLQQRPIHSGSLTLLPIFFSSALFGGCDVTFQNGLLFFFFVFVLSLPLLLFSFRSFSRRGVCCQFCRCVISSLPIFQRHPATLLGHCPHATHTQTFPNNSPFVIFPCDLLFLFFFIVWHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9H3</accession>
    <name>F9W9H3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_45640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001309">
        <property type="protein sequence ID" value="CCD13873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45640"/>
    <dbReference type="OrthoDB" id="1679107at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
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            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
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            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="323"/>
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    </feature>
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        <location>
            <begin position="215"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD13873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="333" mass="36089" checksum="AC11DC108C3E9E66" modified="2011-10-19" version="1">MASGLLRYPSDYRQRYFQSEISVGDPLNVALRLALYLDLMLLFGLAVFGLYSFRGKERVSGAVLHFGWILPGTAAIGMLLSVAAFMIITSNMSGASDWDELRPHLEMMLYETEIGYSWVTRMISLAVVIFVASQSKRWPTGSLWVATLAGSIALSTLAWTGHGAMDEGTKRFWHFAADILHLLSAGGWIGALAAFGLMLRIKGANPEQLVRVLSRALKGFETAGGFIVGTIIITGVANYLFIVGPTVIELVTSTYGILLLMKVLLFAGMIGLAALNRFYLSPSLERSLKAGDYSLAATALRKSVMLESTCAVVIVFLVAWLGTLSPSIEMAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Q1</accession>
    <name>F9W9Q1_TRYCI</name>
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        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1884</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_46400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001335">
        <property type="protein sequence ID" value="CCD13955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46400"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
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        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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            <end position="21"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
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            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="581" mass="65987" checksum="63F8383CA81B5ED1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T4</accession>
    <name>F9W9T4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1894</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001346">
        <property type="protein sequence ID" value="CCD13989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46730"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16054" checksum="6AD7598E7F591074" modified="2011-10-19" version="1" fragment="single">MLDTGAAHECEDVVLVEKSIQSNGKVDYSHVSGPRVLVTDASACGAGCDGVIVLGGSRAASVSSAAEPHEVQKSRVLPVSAVKSGEQGDGVRSDISCVSHITEVEEECRAEVEKGGYGHSETNEEQSEEEGEEEEEEEEEEEEDYEFVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBG7</accession>
    <name>F9WBG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001582">
        <property type="protein sequence ID" value="CCD14600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15675" checksum="7F4FEA84C68423FD" modified="2011-10-19" version="1">MQVSEMWEMCSSRFGLACAYGVSLLIRAFFNGFGGSTHIFHDVLRLRKSVVPFSVTASMCRECFFKVRWVTYTGAVPWVSIPMLSGSVYAQETWLALDTLAWFQGPALSTGHRMDLGGASKRTLTRPTPRASQLSRQSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBN4</accession>
    <name>F9WBN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001601">
        <property type="protein sequence ID" value="CCD14667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52630"/>
    <dbReference type="OMA" id="WCKHMQD"/>
    <dbReference type="OrthoDB" id="1334177at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="40491" checksum="EB689F41E2ABF66B" modified="2011-10-19" version="1">MGSASSCCTSSDGVTDVIAFKDEGEATWRSRLLSDVGRDPLGVTRDFPRTQVYVSAPHRNNYCRQKQDRVTVGILKDEEAKCEYMEKRNERVCESLELLMELCGEDTSAVMSEWGKHKRGVPDLSSLLTTVLSTSGMLQPVTTRENNNADNESTRGETVEGVTAGANMAEESPMPSYTVHSRALRLMQYMVQSIAFFSTQYVIELLRFPWCKHMQDISWAVFVYPEPSSSDGDDVVVLQHKNTLRHYVGPDEQRVKPRFEIEWVCTFRLSLRRLLDGSNTAAKRAVMGPNGEVLSIHGELVAARVEKASNKLCCATSKWKKRRCQLERRLQQRFLVGLTKVSSLEEYESHCAANEGDNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCH4</accession>
    <name>F9WCH4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001724">
        <property type="protein sequence ID" value="CCD14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55350"/>
    <dbReference type="OMA" id="ADEHWEG"/>
    <dbReference type="OrthoDB" id="1660533at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="522" mass="59132" checksum="3AD8DABF116C1B35" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ3</accession>
    <name>F9WCJ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001730">
        <property type="protein sequence ID" value="CCD14987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55540"/>
    <dbReference type="OrthoDB" id="1716671at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16469" checksum="02D98898B881DD54" modified="2011-10-19" version="1">MQPGQQIICANAGNNETHSQCISQHPNTHAPCRGQKPQCGQQLLHAFGLHHVPRVPGCAWCRAVVVTLACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAISGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ3</accession>
    <name>F9WCQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_56140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56140"/>
    <dbReference type="OrthoDB" id="1673961at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390154" evidence="5">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38128" checksum="440FB2A53640653E" modified="2011-10-19" version="1">MMKVLFFWMMVIGVCSSSGGDEKDHNKEAHQALCDLLKAAVKSWGEGGASLPAKLKTALEKTIFGSDGGENDLGKIKAELPKVYQKVNSNVLSRVVLCGQPLLDDMRDNQARWSGHSAPHDLLCLCTPGNSGWPLNLSGNEKLCGKEKSVWGNRNAGWTSGGQGKDEMIATWTNVTRECLEDDGRTGDLQKALDDFKAKLKQKSSDVPKGMYRLGTSKSDDYPCSGNGKICVIYHIPAKPEHSMPWWMDLEKALQIGEDQKEKQKKTEEEKRAKDDQKQQKTQRQGKAQAEHTPRTAALKSTKQDTTDNEQINPENTSNPIATLEDTSSTPISLPSSWLLSAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCV3</accession>
    <name>F9WCV3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2277</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_56630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001772">
        <property type="protein sequence ID" value="CCD15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56630"/>
    <dbReference type="OMA" id="FHAFELQ"/>
    <dbReference type="OrthoDB" id="1551642at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394881" evidence="2">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="NPL" evidence="3">
        <location>
            <begin position="37"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="260" mass="28831" checksum="645C17429C8DAE22" modified="2011-10-19" version="1">MAFIAHVLLPSLYPSFFFLSATCVDFRHRRRSVMSLFHAFELQPGRDYNLQLKPQYCFHLSTVSLPHGGKGRGTVYATVDGKSFSLATLDASGQVLHASLDLVFGKDQKVVFRVKGNAVIHCCGFQQEDDDASVSDMDDISSDGMDEELEDAEVPVKQMARNPAAKSSGAYDPTMEDEETANDDDEDDMDDMEDGEMDDDDEESSSSGEEEDVPPRRDASAKPKAQQREQKAQQQGPRQGQQSQKPSGKDIGKKRPRQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCZ1</accession>
    <name>F9WCZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_56990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001792">
        <property type="protein sequence ID" value="CCD15139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56990"/>
    <dbReference type="OMA" id="TGNQKVG"/>
    <dbReference type="OrthoDB" id="743037at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="542" mass="59085" checksum="D32B6BC17B4E7EE4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD06</accession>
    <name>F9WD06_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001799">
        <property type="protein sequence ID" value="CCD15154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05790"/>
    <dbReference type="OrthoDB" id="1676005at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="292" mass="32634" checksum="424FFBC5199C8E7F" modified="2011-10-19" version="1">MDRGSRCGGCHQEEKFYYPGSSITHDLMCLCTPGKAAEPFYGYYWWLFGYKANGFKLCGKLKEDMGVNLNHGWYSEGRKKEANGLEKSWKAVIMGCFNGWKNRNITGSQDLTEKLQKLTEAMTNFTKILKQVNGMHKLGWTKEHTPSDGTDEKRIHVHYNTCNGKRKPWWKRLNETLTSKTPEQLLVPRKTQSPSSEPSEELNDGPEEELLEGFAGVEGSEPESFTADGGSASQVDTENATQMQGPTNSTESTVIPLNATASGNSSHPRLEYLRSGSHINQPLLFLGAIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD54</accession>
    <name>F9WD54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001822">
        <property type="protein sequence ID" value="CCD15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05900"/>
    <dbReference type="OMA" id="HIELLRC"/>
    <dbReference type="OrthoDB" id="1281658at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="SSF81382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20167" checksum="E60568D06C94151E" modified="2011-10-19" version="1">MVTCDVTLVSSDQTHVTIPSAAAWQHIELLRCLVALDEGGCEEMPPIELGFASEVVQAIAAYLQQTNRIAVDVPKPLTVPLEQLVPAWEMEFVRNAERCELLLPLFECTCYLRITGLRNLLAAYVAQRVDEIAKEAPSIMEGAAKVRAYLQLENEWTAEEMEHLEEEMRYAKQVDPMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA2</accession>
    <name>F9WDA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_05950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001844">
        <property type="protein sequence ID" value="CCD15254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05950"/>
    <dbReference type="OrthoDB" id="1713217at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21307" checksum="8DCD58BF5ADBC47F" modified="2011-10-19" version="1">MIESGLSTEPTIVSLQRALYSLTFRLKQGTNNDGYFYLGGDGKNVCSGNNQNDVCVAYPGDGEKADISWAKRTDEALECIRKNIQQRTERQSSNPATNTRSKLGNFLGNDEHKGQSGPISGKNDEKDEDTEEKTEIFESQDRSQVERLRRKGSTQSSTETNIVSIATDTKEDGSFITIQKRGASCRLTQLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDD2</accession>
    <name>F9WDD2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001857">
        <property type="protein sequence ID" value="CCD15285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58160"/>
    <dbReference type="OMA" id="NNEMMRT"/>
    <dbReference type="OrthoDB" id="918434at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="438" mass="50875" checksum="1409C2C812709887" modified="2011-10-19" version="1">MADTSVNSESQLELERLDEIIDKYTCQLEHINSMLQAVEEENNNDSVSRQIAEYQTAFESNPENIPAEDALDTITRMQNTLKIVMRRNNLLERENGTQSRLLEERSSILHNAVKTYERILKETGWHDKYAHDIDDMKSKIEDMKEMSNIAAAVQRELRVAQGIIRKKESAICQLEELVNKGKEREALINNVYNAIRVKERDCSEIELQLARLRRSVAKTDEALSVFDVQSQNSSLTYMENDKNYLKDAVSNMKAMTRRQDSVIKAQLLRQQQLQTRLDTITKALREMKLDKKYERNVPKSALVPSACREEPEDVSKILPVGECIPVHTYRLLYKNNEMLRVNVMRKNMLVLEKKCVIDALEAGLARYGAALMTTYKEQQDLRQNKEVEMLELMDDLQQQHSTYLTKLEELRLENALLKKKIFRSKRQSGSLRSSQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL1</accession>
    <name>F9WDL1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001884">
        <property type="protein sequence ID" value="CCD15365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58920"/>
    <dbReference type="OrthoDB" id="1712348at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21017" checksum="9CCCC00C58F44352" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVEVLLEGVASADKINLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDALWQYLPYLLWKFRQSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPPPYQPYQEVVVVEAAPAFIQVPYSTVGYLVPIPLSPGSWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDN4</accession>
    <name>F9WDN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2383</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001890">
        <property type="protein sequence ID" value="CCD15388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59140"/>
    <dbReference type="OrthoDB" id="40634at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="34536" checksum="4CEB8E75EAFB0745" modified="2011-10-19" version="1" fragment="single">MEKDEGFPAKSRARADAPKNVCVSGQSIREVMHCPKAWVSLSVGNYEDAYALSTEHNDLLCSAAVFVMRGEVSNAVKSIEAFVIAGGIVMSERMKEMHQNDYASLKRLGTIVVCYATRGSISLKDIEGNLDLTPEEIQAAAVEACDIVDWDLVHRWFIIALFLHEGGYVTPRVAWFHSFFALSSGGRADAKSPASTKKQGSEAKATGRKASICNSNTCEALDATRLTDILLTHCSQNEILFITIVCAWRTRRYRTVITKAREFLLMEDGGVVFDDNARVMVRFMFIMSLVEIGERTLLPRRWLHSCDTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR3</accession>
    <name>F9WDR3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001899">
        <property type="protein sequence ID" value="CCD15417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12272" checksum="EB27ED0002435422" modified="2011-10-19" version="1">MAVWDSVLEMEPACFAGEWWPRLTRWCGGSVRHRGTEPRPVVVAVHPLKSPQTPRVWRTARDIGGIPSVGVISRGTHNSHISESKLALGQISCYEALEMQSHLPHISLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY0</accession>
    <name>F9WDY0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001928">
        <property type="protein sequence ID" value="CCD15485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="909507at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16307" checksum="F3791394E64D43E7" modified="2011-10-19" version="1">MEECGAMVGEQQQMVKRYEFIGVLFDHDTQTVSLSEKMIRRVRESPPLEEATIEQMECVVSRLICVAGVREESLFPCYFFLKMVRRRLSRLNRGLARPSDPAALPGQALILANMWMNRLLKNGPVTPPQNLPTTAALVTDASIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE41</accession>
    <name>F9WE41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2434</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001947">
        <property type="protein sequence ID" value="CCD15547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60390"/>
    <dbReference type="OrthoDB" id="1730824at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="19893" checksum="FB1235DC574A5D10" modified="2011-10-19" version="1">MSRCSTASLATYDGPTGDVNTAFTHLVKRQLLSAPRTSVVRASPIYRAVVCHYSRNDVEGPRHAGSDDTAKSDVSKQFEKGKKAPAATVEEATTAAVAVPAVGVPAAVARRGVVLRDPLLLRKLRKQQSGTPSSPGCTRMAVCSSGQETGHKDAGDDGLGRGEDSVGVHWSKRSLHLMTAVGWDVFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE62</accession>
    <name>F9WE62_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60540"/>
    <dbReference type="OrthoDB" id="1665011at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="44192" checksum="0B07C90173E864C7" modified="2011-10-19" version="1">MKGSRIIGKEKGKGVWWSLLLVTLWGMGMKGVSGVYTYSSGTIFNGKEHDALCSVFQSGLDLWNASRNSDLKLASGLESALGQALFGNIVRKDLSGITQGPPVAYKSDKPKHRGIWCGTCNNKYYYPGSSITHDLLCLCTAGQYGRPYYGHFWLFGWHPKETSFKLCGKERANMVENENSGWHAKTYYKNQQAKDLDKTWRTVVWGCYNSWKSKAVQRSHNLEERLRALTGAMENFTNKLTIDRNKWHKLGGFQEHTESDGSDERHIHVRYGPCNNARKPWWRRLQEALRGKTPSQLLLEPSVASSQATRSEHEADGKGEEKNFLKMGGEGHMEPGENTGLRGPQPPRCHDPKIHGSPQIPNHRTPRRGRPQGTPPTFQYLRKGRGSTLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE88</accession>
    <name>F9WE88_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_60800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60800"/>
    <dbReference type="OMA" id="AVWNDEY"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390214" description="ATP pyrophosphate-lyase" evidence="8">
        <location>
            <begin position="47"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="9">
        <location>
            <begin position="886"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD15594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1246" mass="136232" checksum="47E2B29955580AFA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEA6</accession>
    <name>F9WEA6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2451</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001965">
        <property type="protein sequence ID" value="CCD15613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60990"/>
    <dbReference type="OrthoDB" id="1704425at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="21131" checksum="742DFFBF226F80E5" modified="2011-10-19" version="1">MQKSLYAQEFYVHRVADRKHIRLYLIIQRALLQKHLTRAIATGHAPRFSILGTGRATGHRGDHVMSRNVLTDAFQQVFHHSKLMGCLRRSKLCPTDTTHTLPYRWCSSFEKKVTPLKRCTGDTGNRTQHPVYIILPDILLDSFKMKSRTIGLGKKGVPILQGSPRKPREGSGRIVATTKCGWTNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEA7</accession>
    <name>F9WEA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_61000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001965">
        <property type="protein sequence ID" value="CCD15614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="12114" checksum="9AB828F06D721A6E" modified="2011-10-19" version="1">MNTGFGGGIGQQPAPGVFGQQSVGAFGQGGVTGGFGQPAATGSFGQAATAGGFGQQPATGFGQAGATTPFGQAAGRGATGGFGQPTAGAGLVRLLLQQVLLVTRPQRGLWEGATAGGFSHPPQQGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WED1</accession>
    <name>F9WED1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 249</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001992">
        <property type="protein sequence ID" value="CCD15638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06570"/>
    <dbReference type="OrthoDB" id="493676at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="508" mass="54458" checksum="3659C79641846A62" modified="2011-10-19" version="1">MAGVHPYMALSPPAVLRVLAALAADVNPGYPFSIGDSFGVDGKLEECSFANADSNRNNNSELTQVMALLLASYDSVERLQYTYPTIRYVPPPTDTETGNPSNVVYPLDEFAVRARFVLLGAATDAVQCGHPWLECLSNRCAQTGAINIGNVCHCGLGEDIAPRVVTNDTSPSGGVALMRQGIECALRLPVCVMQDKLNEWQAQLDVCGTEHHRTTEGGTSHDTKKAQIPFLSSEVLSWVMKCVESVLELPNLYGMGKPAAASRMTSVQRSFESSVQSPRDTDGMGHRITAMAVVDECLNETTRSGASSSNNGTPALSYHWKLFLPHSRPFAVGTADIHRSTVAVDLFDTQSSGAQPEGLITAAEVIHFTLMHRLLADVGIGLKLHVRFCYDNEEDTLFQWGPAGQTNACAADRDNHSLLSSHSLLDCASEKPTAAPATATCVGREATLSLQLSPDFSGSLLWEALETAWTSVVTAVKVGAKDAQSRSLPLMESQKVSDVCQGAAEVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WED7</accession>
    <name>F9WED7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001994">
        <property type="protein sequence ID" value="CCD15644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06630"/>
    <dbReference type="OMA" id="PSANSHT"/>
    <dbReference type="OrthoDB" id="1535721at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="287" mass="32055" checksum="6028E11E66D5E8D0" modified="2011-10-19" version="1">MSRDSSKINAADSPRFLDSRGFSCTRVTTRWVDRLHDNNKKLIQVQAALGSLSKQLDEYNKELAIVYINADLLITLRIAEYRQKIGSAMASPPAKKMRSKRATTSRAANRLQPDSNCTEALIAAMDEKKRAKVSTILGNFFKREIHDQGGSACYTPQPPSAQCLPSPAMQVLTTTAQAVEPRPTAPTNDSSKLFSSSGVNTRDLCSSFTDHNPNSQRRHRDVPPEIWEEMVKLRLKRLYLEEQIASLVTSIDAQTERFHCLMQIQAIGQYVTDGALPSGGFVRKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF3</accession>
    <name>F9WEF3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002002">
        <property type="protein sequence ID" value="CCD15660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06780"/>
    <dbReference type="OMA" id="VLYENEY"/>
    <dbReference type="OrthoDB" id="895119at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="541" mass="59823" checksum="F6067A01BE206782" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEJ5</accession>
    <name>F9WEJ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 277</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002023">
        <property type="protein sequence ID" value="CCD15705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07180"/>
    <dbReference type="OMA" id="VCAPIAS"/>
    <dbReference type="OrthoDB" id="833306at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="301" mass="32682" checksum="CA3EE85E8BDD52AD" modified="2011-10-19" version="1">MLGPIQVAVGFVVGIMLAYALYFSVFNIFYKEGERVPLGGLKILYFTERHSNHVRFATMTLILLFSMLCTSVASLVQCVGGAAVAIVVMLSLFSHWCDAAHKLEHDTTKGDLSVAFRFVWDYIAMPGLFGLAGSTVDFGAIFTKDFFGSGITCVLTGLAVRFVVSALTPFLFRMPFSFRELIFTGIGSLGKGPLQAVFAGIPLLNVNEQHGSANPTNLTGRSYEEDVRYAETLQNSTILSMLVACLLCSTLLSVFSQKLLRHDAPCSLSGDQMEIISNGEDCPPTSRCTAGRGPDITTRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM6</accession>
    <name>F9WEM6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002036">
        <property type="protein sequence ID" value="CCD15737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07490"/>
    <dbReference type="OrthoDB" id="1729042at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15791" checksum="0D8978B4DC282EC8" modified="2011-10-19" version="1">MIYFSFYSNQSGKFKPFQYKTEPLMVSALFPFIASAAICWCAFTLSCTFRYNVVGSFFPLTSNVLTGACFIHTDSPSKQTDKYPSSSNKCRPHGSHISVPFTRAHPFRYAPHSQLPVKLLLPMEGSAMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEY6</accession>
    <name>F9WEY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_08490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002077">
        <property type="protein sequence ID" value="CCD15852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08490"/>
    <dbReference type="OrthoDB" id="1674284at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390270" evidence="5">
        <location>
            <begin position="32"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="58"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="39987" checksum="7CEC2C640996A97B" modified="2011-10-19" version="1">MVGEKVKMTRMMMKVWMIIIVSMWVSANVEGTDHNHDAHNALCDLLSVSVKKWGEVKDRKHDDPLRKALKQTIFGNESERDMAAFRSKLPDAYNDKESNSGDRSMWCGQPFEDSHEISNANQPRWSGHSATHDLVCLCTAGENGWPINGSDTLCGKGKDDLGGGSEGWGNKNRKAETQLKATWFNVTSECLQSDEKRGENLKDALDKFLRRLKHEPEEVNKNRYQLGEGTPGSYTACTGSFPYGVCVMYYNGTIVKKEHMPWWVDLQNALPEEEKFQEEKRRAEERRRQKEGEQRTDEPHTEALKSGHPTTEENEQHKTNNFTDKLRKLNLTSGTSISQPSSWLLRAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ1</accession>
    <name>F9WEZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002080">
        <property type="protein sequence ID" value="CCD15857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08540"/>
    <dbReference type="OMA" id="VEAECEM"/>
    <dbReference type="OrthoDB" id="1057659at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="517" mass="57666" checksum="064C95A9EBDF18BB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF83</accession>
    <name>F9WF83_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_09370</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002115">
        <property type="protein sequence ID" value="CCD15951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="770"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="815"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="905" mass="99960" checksum="AB5B9B62A4D22490" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA6</accession>
    <name>F9WFA6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16740" checksum="DC69C6DBBA635010" modified="2011-10-19" version="1">MMCAVGLCGLFSFRHFPPEVVRRHLLRLDGGLARLQGEAAASHDALGIGSTLFRWMWWHPSKNVCQRRARWWQTPPCACGVLFYLTEVAEVWTAGLAPKALERNPSDSLRMCINSATVMCVTRIGCAHSAAQMYYKRTLRSVELVCGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC0</accession>
    <name>F9WFC0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002125">
        <property type="protein sequence ID" value="CCD15988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09600"/>
    <dbReference type="OrthoDB" id="1727443at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="18496" checksum="1F59AA15D62A6FA9" modified="2011-10-19" version="1">MPGTEFSRGPSSSIAIASSKGPGLSHRGTPQVAQTLSHTVLLSFTLSLTQVKKALIHQPIHVLTFVPTSARIVCQRSSKSIPCSQSMNTDAARVALSSGVRAFPRNVHLVSPSLSHIHIPLFRRHSAYTSSLTTSRTHLHHTGSPKLPSALMSRGTSPPTTNSSLVPLALGPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH9</accession>
    <name>F9WFH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 388</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002146">
        <property type="protein sequence ID" value="CCD16051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="WRILLGH"/>
    <dbReference type="OrthoDB" id="390387at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1473" mass="162639" checksum="3AFDEC807420C732" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK4</accession>
    <name>F9WFK4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10430"/>
    <dbReference type="OMA" id="SHVICEA"/>
    <dbReference type="OrthoDB" id="773833at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="373" mass="41781" checksum="473943094C6D3C86" modified="2011-10-19" version="1">MDSNIGAVSPCDAAKEALLRLEKAAVHIHAEHRQLRRSVMTMQCRLKALLSREAEAPMGTAAAAVNQPYCHEVERVRTVAACHKRGVALMKHKALVAELWERHVVKSWLKNDVIFGFYYVVLSRLSELEKRIDQLNALLHPRRLLCTSLFLKGVVDQRRVRRLGVVLNLIARVPRNFVGRAKLATKGLKADLPQSLSPLFTVDEISEVVRYIIQKTLEEKRPLNEKFIATVQTDAFLNTLNASPLLAGFITEWKADVVLPLSNSLRQCASSRCVYERYSQATLALMAGNSRHASDTLFTRRQQRERDDARWCHLRMEAAEVLRRISNEETDVAASSLGSSLSAALKSAGDVVDPLVCLLSLVILSTQREAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-04-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM8</accession>
    <name>F9WFM8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002164">
        <property type="protein sequence ID" value="CCD16104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="870069at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="14503" checksum="F88CE3BBC766229B" modified="2011-10-19" version="1">MLCRGVKVEGEAADSGSQTPGTLTELTRWKAPPDIGRRYARVSGDYNPIHLSTPTAKLFGFPQAIAHGLWNKARTLAALAEHLPAANIEIDVAFMKPVRLPSEVILMSSAAGSSGTLELKGAGDIQHMLGQWQPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG63</accession>
    <name>F9WG63_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002236">
        <property type="protein sequence ID" value="CCD16297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12370"/>
    <dbReference type="OrthoDB" id="1711026at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21492" checksum="7140E4C147C81C31" modified="2011-10-19" version="1">MSTKLSSLKSFPLKQSFNSSFVAGLVSPRQCVLLSLPLAFANTVINSSRRPAELAAKAALYASLSNFSTSYPALSISFRTCRNRRPVILHVSEPIPLDLDWMNLDCHSSNFISRWVIFAAPFSTCCVAQGVTSFNFLLKVHMAASNIVGIALCPLPKVSSASSINKAISHHHLVRNSITITFSLYLICLPLLKFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF5</accession>
    <name>F9WGF5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002267">
        <property type="protein sequence ID" value="CCD16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13150"/>
    <dbReference type="OrthoDB" id="390245at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="406" mass="44535" checksum="6535EB6BC6FC7878" modified="2011-10-19" version="1" fragment="single">MEDKIVRDRCSAVVQQIVFGCKDKQLKQKEQQHAQRSRLLARVAEALKQKAIVTYRLCRAKGEKLSDDQTEDAAYCALAAVAWLQPALWATLVEWSRLLFPRTPVLRFLSPVAMVVRMKGVQHFIARSSWLQTDTPALMSVRPMPGASSSCGAKATDNPETEEPCGELRGQSRGKRPRDVKYNPQGAILEEEFVFQVALAYFRLTVPDVRKLHVIVASCQGAGKGTNWIADVDPQLLTPCQPFTSNRSTTRNSGANLCSNSNIRKEDADDEEEFGDTSLALLGVYVPMLDDATCQGAAAAGKEGSSLLTSSINLDTLANDVDSVRSVIYYTSLQRCLRNPLLFSSLGCITEGKNVEQANDNNVGSIQHSRASINMVNTATVTSPHSPAHFLHPSRVRLHSISPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGM8</accession>
    <name>F9WGM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002292">
        <property type="protein sequence ID" value="CCD16465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13850"/>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031083">
        <property type="entry name" value="YTHDC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF100">
        <property type="entry name" value="PTHR18934:SF100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17730" checksum="877804B06DFDD361" modified="2011-10-19" version="1">MTLRKRQRSHESPGGCLAIFKSTFQTKGFQGLQRLIAPRVEYMGEVIDGLTRLLFHRMTREVKLSDEGAHESYPLAIARCGLQSIPQCAMPEKRYRFLKEFRRSLPSYRHKDVIVESVRRGAVVVISGGAGCGKTTQIPQMLYDEEGLFDKNLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH10</accession>
    <name>F9WH10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002359">
        <property type="protein sequence ID" value="CCD16599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15090"/>
    <dbReference type="OMA" id="CNSAGEV"/>
    <dbReference type="OrthoDB" id="1653678at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1348" mass="146122" checksum="CEF287838A747E51" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH65</accession>
    <name>F9WH65_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 602</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_15620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002383">
        <property type="protein sequence ID" value="CCD16654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15620"/>
    <dbReference type="OrthoDB" id="1660683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395047" evidence="3">
        <location>
            <begin position="23"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="4">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="4">
        <location>
            <begin position="241"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="4">
        <location>
            <begin position="452"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="689" mass="72830" checksum="2E10138BC222025A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD1</accession>
    <name>F9WHD1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002415">
        <property type="protein sequence ID" value="CCD16723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16290"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="223" mass="24406" checksum="3A07F309B685E54B" modified="2011-10-19" version="1">MILRHRELVSAFEGRASADRLLFATNLPHWADRNTRSEFVQQFRKAEKNSSRWTPLTLLGYAASRFAKAVISPVRVVNADAVVEAVFAQYMVAVDDMRYGPFDDNNCFLNGASRSKGCAANYGATQISIWSMTRVLNVSAPPLTSPVTPSITYSVPDASGLTPAHLAGIIVGSIVMLLFFSMATTLLVRCEAMRNIRDNESAPKEPTDPVTLIFTDIESSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHH2</accession>
    <name>F9WHH2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 648</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_16660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002435">
        <property type="protein sequence ID" value="CCD16765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16660"/>
    <dbReference type="OrthoDB" id="365003at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_N" evidence="2">
        <location>
            <begin position="281"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="527" mass="60602" checksum="C99CDDAE0350D577" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI8</accession>
    <name>F9WHI8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002441">
        <property type="protein sequence ID" value="CCD16781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16820"/>
    <dbReference type="OrthoDB" id="1710296at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15737" checksum="BF3BE66529276B09" modified="2011-10-19" version="1">MIYFSFYSNQSGKFKPFQYKTEPLMVSALFPFIAPAAICRCAFTLGCTFRYNVVGSFFPLTSNVLTGACFIHTDSPSKQTDKYPSGSNKCRPYGSHISVPFTRAHPFRYAPHSQLPVKLLLPMEGSAMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHK5</accession>
    <name>F9WHK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002449">
        <property type="protein sequence ID" value="CCD16798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16980"/>
    <dbReference type="OrthoDB" id="187018at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22827" checksum="808845A989185D89" modified="2011-10-19" version="1">MLLVRRTLSVASMHHANVPAFSGHTSVMPEVTVVVSKDVAITLGSMHLLAPYNQNNANNRTTQLENLTKRLRARPFVNGKQAGAIVMGDFNDCAKNYFTFPEDMGFKDAWLLLHPDEGKQSTEGFTIDGDRNPYAARIIEREFNGRADRVLFCSRNLQPIHTEIVGTTSVRAMGITKQVNCDKDVPEYLYPSDHFGLLVEFQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHP4</accession>
    <name>F9WHP4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002468">
        <property type="protein sequence ID" value="CCD16838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17280"/>
    <dbReference type="OrthoDB" id="1729179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16202" checksum="E2CDC481269679E1" modified="2011-10-19" version="1">MRRCHLPGGAAAVVSGVRPGFAGGSAVGSLLRAAIGSRAHWFGSRRVSTFPARPRSTSTQSVPVPSQEERSLTRSAPRTKRPTRSALQESYCMHGVCAWELPFPAGNLRCFQIANFVYWGHVALLRTRSAFSSTALSTKIVRATGSVRGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI75</accession>
    <name>F9WI75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002537">
        <property type="protein sequence ID" value="CCD17020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QREHESY"/>
    <dbReference type="OrthoDB" id="1624143at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16758" checksum="706C5E3BC8F7FA55" modified="2011-10-19" version="1">MPVLPSLTPEEKAARERRLQAEHDHYVNSIEAMRSLPRLRSTVAGAGGKTNEHVRLAEEREAERRQRLQIDAERLMEKVRQEKEHQAKVEALESRQQKKRGRANKRKMRKAKYRLEGGKAECVVSEGSDAGSIESGSEGNIVKDETGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI89</accession>
    <name>F9WI89_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 749</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002547">
        <property type="protein sequence ID" value="CCD17034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18930"/>
    <dbReference type="OMA" id="HRMEATR"/>
    <dbReference type="OrthoDB" id="603827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097027">
        <property type="term" value="F:ubiquitin-protein transferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904668">
        <property type="term" value="P:positive regulation of ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="PTHR19918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="865" mass="92334" checksum="6DA8FD13061DBA7C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE5</accession>
    <name>F9WIE5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 777</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002578">
        <property type="protein sequence ID" value="CCD17092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19440"/>
    <dbReference type="OrthoDB" id="1703595at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="25085" checksum="994F79CEB7A20FEA" modified="2011-10-19" version="1">MTWLPISLKNAAKCDKWYQLQNHHIAQSLNANGAWEKLFRVIPVHATFSVSTNKKTTAALFFSLSLMMSRVCGVCAVCSRDVFENGAGVCMYCRPLLIFHAVRRKRVRCVYCGVVYVRVKGCMWYVCGGESVARGLCVCLLWGGVRLHFVPLETRPLSRLPSFPLRVITAASFHPCSSGTPPLPPPVFTSKLFELKRQGGDVAVRRKAFFPPQQPSPPPHCGTVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIR5</accession>
    <name>F9WIR5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="5">3.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_20500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="5">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01002629">
        <property type="protein sequence ID" value="CCD17213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20500"/>
    <dbReference type="OMA" id="FWHKAVA"/>
    <dbReference type="OrthoDB" id="371693at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="190"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="437" mass="48451" checksum="A957C572E350D96C" modified="2011-10-19" version="1">MTDYKIRDISLAEWGRRALELAENEMPGLMELRREYGPSKPLKGAKIAGCLHMTVQTAVLIETLVELGAEVRWASCNIFSTQDHAAAAIAKRGIPVFAWKGETEEEYMWCIKQTLKGFSGDGFPNMILDDGGDLTNYVIDECSELVDKIYGISEETTTGVKNLYKRLQKGKLPIPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKTACVCGYGDVGKGCAAALRGFGARVVVTEVDPINALQAAMEGYQVLLVEDIVKDAHIFVTTTGNDDIITSEHFPHMRDDAIVCNIGHFDTEIQVKWLKENAKERVEVKPQVDRFTMPNGRHIILLAEGRLVNLGCASGHPSFVMSNSFCNQVLAQIELWTQRNSGKYPRGDKAQVYFLPKKLDEKVAALHLGKLGAKLTKLTPKQAEYINCPVDGPFKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU0</accession>
    <name>F9WIU0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 833</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002639">
        <property type="protein sequence ID" value="CCD17238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20740"/>
    <dbReference type="OrthoDB" id="304711at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="38011" checksum="1DE7F3786DD22477" modified="2011-10-19" version="1" fragment="single">ALLEGEQTAAGATAALETNDPCGESVEERSSYASLLSSTFIRDGVQLLKSRPEVAIAFITTILHKLPTAEAAVLFVNEAVSLYRGSSCPAAAASVRHPVVVNALLKKCVENNSWHLALSVLKTASPVAIPCEVGSALLLQMREANQVSLVVDVLQKHIVPTRSKLSREAVEAALFSVLKHNCAVAGFCASPTPTRDPADTQVENSSGAMATAGVHWLSALSWAVDLLEDGVEARILQAGTAPSSGAVSQREPTVLPRVKTLSSRALSLLIHICVSAGSARGGLLAMGYARTADKTELDLSEEIRALLYCMMYNRPVEAESIVQHAVKKYGEGRSRHLQRLWKAVQGANRSPSWQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ6</accession>
    <name>F9WIZ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_21250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002667">
        <property type="protein sequence ID" value="CCD17297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21250"/>
    <dbReference type="OrthoDB" id="1667029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390409" evidence="5">
        <location>
            <begin position="17"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="401" mass="44336" checksum="BBA1974A53D2CA74" modified="2011-10-19" version="1">MMKLFMVIMVVMGSWVREWRVMANGENSVNEKDNSEYFSLLCRIYNVANHPPLKPVDTKEYQKIVDDIDALSAAANGKGSVNTQSEETKSAQTQLIGITREAQKLLDGIKKVNPEGQAESARHAFNQVIFGEHGKEGDLYHGTLNGVRGRMGACGIKPLEKKGESAGKNLIVDFFCLCAKHDVVDGVDKVCGVSVGNGRDSRWEGGTLDSANTMWDEVKNGCEKFSKNGVTSTQDGYSLYNDFLEKVKVGGNVKLKHSSTVHKPGMLGTAVSETERNDFHCNGKKEVNNGRFNVGSGSGVCVSYGNHHLEENIDWLKKFKYGLQLIDKLNTETASWQHQLTTLLNRARGLYEKVKADTQLEEENTDDSPLAQHPNPDENENADSATQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ08</accession>
    <name>F9WJ08_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 859</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002669">
        <property type="protein sequence ID" value="CCD17309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21370"/>
    <dbReference type="OrthoDB" id="1729073at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19920" checksum="2FB291973A630593" modified="2011-10-19" version="1">MVVLMNALMRCFAGLFGRSFFPFLSFFSFLFFLKISIHTIFRVYCSSIFVRDVAFTACLSNPNSFFICFFLFCYSLAAYFCHLLNEQREGSGEGGVGGVIPAVHQRFYTVLYFTHLCAIAHEQWQQPYVCVGHKNTFSATCVTCARTVYFYTNIYMYLYFLALKRDLLITVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ84</accession>
    <name>F9WJ84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 885</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002697">
        <property type="protein sequence ID" value="CCD17388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22110"/>
    <dbReference type="OrthoDB" id="1690852at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="234" mass="26457" checksum="CC07ECB2F289BF0A" modified="2011-10-19" version="1">MQSDLQPVAGRIKIHKAQTEELQNASMDLQATVDTMDSKKVHRAKLTGMAGKIQSSIDRLDLPTSQPWQSRETLRLSCGHLPLAFNKEKQLGKATPFVRKVCICNATPDSADCKREEKRKNTSVFYTLHSLMAELIGSNTFYVFFHPKSQSVQRDSTVVAVLFPDMHFISNIFLQFYSFSKVTHPRYGHNQNSTKPLQGAELTLTKVHTSLCSFFPISSKDCKVTTRFFKVPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA8</accession>
    <name>F9WJA8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002704">
        <property type="protein sequence ID" value="CCD17412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22330"/>
    <dbReference type="OrthoDB" id="1666332at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389219" evidence="5">
        <location>
            <begin position="20"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="84"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="43833" checksum="9C0D540E36E54AE9" modified="2011-10-19" version="1">MGKMMKLFMVCLVVMGSWVREWRVMANGEHSVNEKDNSEYFSLLCKIYNVANHPPIKPVNTKEYQKMVDDINALSSAANGKESVNTQSEETKSAQTQLVGISREAHKLLEGIKKVNPEGQAESARHAFNQVIFGKNGKEDLSPGGLEVEGSRPKACGSNEKEGKSAGKNLIVDFFCLCSQHNRDDVGVNNVCGVSVGSGDGAGWGTNIQSTPIMWNEVKEGCEKLPRRGVTSTQDGYSLYDDFLARVKAGGNVKVKDSDIVQQHGMLGTAVSHIGNINFNCNGQKTFPTRLSSGSGSCIFYGTHHLEENIDWLKKFKTGLNIIDKLNTETASWQHQLTTLLNRARGLYEKVKADTQLENEDTDDSPLAQHPNPDENENADSTTRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJE5</accession>
    <name>F9WJE5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22680"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390488" evidence="5">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="87"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39928" checksum="CB383E411C673893" modified="2011-10-19" version="1">MVIRKFLLVTWLLCVGAGRQCPSSAEFNLFCKLLREANYVMHGPVYVYDEDKDKETLKVMQVLHNATTKNMKEFQKTLWDMKDIFQEHSLPTRPENWEKAHKKMGYFVKETEMEVDKNRNLAKQVNEKIEAAKLLLAQGIYGDHVMELPKNDGNYMKVLENTSSIFNDENSASKSCGNTQEKAGKTLINDLFCVCVGDADDAQGPCHPNIWPPKSWGYTGSTGNWTQIKYGPDYPTLIPSFNESLHIMEQVCWENMTENNVKSENITALLEQYVSLIGKGNGGVKQNKNIFGHSTRSKNRGQVKECDGQQGNWHHNGPEKKTIKPASTTLTIYKAKNTTSPGTINLEKLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR6</accession>
    <name>F9WJR6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002760">
        <property type="protein sequence ID" value="CCD17574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23850"/>
    <dbReference type="OrthoDB" id="1666928at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390442" evidence="2">
        <location>
            <begin position="29"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="406" mass="45530" checksum="EA61A0A67DF50EFE" modified="2011-10-19" version="1">MWEQRRMGNGIMAMVVSAIFMCINGVRGNDVADYKPGHNFNGAEHDVLCEVLKASADLWDASRKTDLKLDNGLEKSLGQALFGKESGGNLGDITETLPPEYNMVANREHMCGWCYKQDYVFPGKSITHDLMCLCTPGKYAEPFYSYWFFKLIFEETGFKLCGKQQQEMVKDKNDGWYVDGQDKKAVGLQKSWSTVIMGCLKGSVNKTSISKDAEHKILQQKIKRLNTALQDFVNKMVKDDKGRPKFGGTHRDNTESDGKDEKSMHVRYRFCGGQKYGGGRSKRPWWQRLQNSLGKNQEQLIVSRQVTTQASGGGDGTEDSEEDETLDAEGENFTPEKDSDTHTVRTQDSNGNSTHNSTTNRSTESTVIPLNTSASGNSTYPRLEYLRSNAVKNLPCSWFLGASFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJU1</accession>
    <name>F9WJU1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 950</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002770">
        <property type="protein sequence ID" value="CCD17599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24060"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="18244" checksum="B8E5900F1F980943" modified="2011-10-19" version="1">MNLSPVRCFKCLLGCLLCILGVLLGILALLRGGIGTVHSLLAIFPRFRGLGLLIYCLIKLLPHGDWQMPKLLRQLTECVHLLQRELFVFFFILFLIQIVFFFVKRFFCFVFYFIYFSMCFYLFCCVVFVLFCFSSCFSLFFFSVHSNAAACPVVNYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK03</accession>
    <name>F9WK03_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 975</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002797">
        <property type="protein sequence ID" value="CCD17664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24680"/>
    <dbReference type="OrthoDB" id="652922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="27228" checksum="1ACEEDFE36242483" modified="2011-10-19" version="1" fragment="single">MMGDVSEYVMQFCLDETGNSTGCGNRRRKTLIPLSHLAFIPPIYLLIVNSFLCTAINAMFNYFSFGRSAIETTVKGWTRAKMLIKHSVILKEPDDTQNLLKERENSCETDHLCDSGSLGIDYNDSAAFFRGMLNPDSLAFESPRVPASVAEEVLCSSLDAVKSSVQQVVLPFHPTYMIVSITKSLIMLLVIQYHFNFRGGWKRLVVCSAANLMSGLLSPLLEYGAGLLLPVDSNTEMKPAPDWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK07</accession>
    <name>F9WK07_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02620"/>
    <dbReference type="OrthoDB" id="1204142at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="31086" checksum="1D90DA543BAA872F" modified="2011-10-19" version="1">MDTTDAVATMPKKPKSKIDSCPQQSKRHATHSARHDKYHRCDCYGHTLGLPNYKALAQPRTNNYYNAVGGCPCIPRSVARPGSWRQKRDQIRSASNYRQTWCAKGHPNATCCVHAGEAYGWLPGPHGVLSKNCAASGLCDTFGNMEFKRPPRRGDIGSDVSSVNTQKLEGLESLILKEHGERRRIEMDVDELEEIKKKGTEEDYKLDFHNEKSRKLAMAATESQLKGLVREVRGIVDRPLNQTNIDILRGIIDRQERLMKLRAAKATEDFPPIIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3B4</accession>
    <name>F9W3B4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1032</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000387">
        <property type="protein sequence ID" value="CCD11623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25920"/>
    <dbReference type="OrthoDB" id="576917at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="85"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="31996" checksum="F2CF8D33E8407528" modified="2011-10-19" version="1">MILAFIGVTREEEQKNRVQYTINELKSNQRAAKLLAACNIKNEGTVRELSEASLRNIISFFRFEKQQDIRHFWVNVTNERSKLDIIANIVAQLQGVQAIMFCDQKRVLDMCKVGNKMSRYFGGVVPLFIHRGIPREERMQLLQEFKDGEINENGVRERLLVTNEDYAKLARKTVIPYVNLVINYSVPRSEEYYRLQSLVAGRSGTVGVSIVCVSAYEQTFFQELRQNINFEQLEEEVNFRDTAVQLVYDTEDKPLTDEDADPPKDWREKLKCKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3E7</accession>
    <name>F9W3E7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_26230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01000399">
        <property type="protein sequence ID" value="CCD11658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TRREQAN"/>
    <dbReference type="OrthoDB" id="445763at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="227"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD11658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="39182" checksum="694EF5B069797B01" modified="2011-10-19" version="1" fragment="single">MFLSQLSGQWSDSLMHDTLQQVFGYPHFRLGQEETVSAVLAGRSAAAIFPTGSGKSLCYQLSAVLLPHLTLVVSPLLALMQDQLGFLQRHGISAGSIDSAQSRDEANDVMARARSGELKILMISVERLKNERFRNFLNSVQISLLVVDEAHCISEWGHNFRPDYLKLPDYQRQFNIPQALLLTATATPQVIADMQAKFAIAAEDVVTTGFYRPNLNLLVEPVSGHDKRRRLLEWMKARANQPSIVYVTLQKTAEQISEHLNRHGIQAEAYHAGLPHEKREGIQQRFMGGRSNCIVATIAFGMGIDKSDIRNVVHFDLPKSIENYSQEIGRAGRDGQPSDCLVXATATASCAGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3R4</accession>
    <name>F9W3R4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000457">
        <property type="protein sequence ID" value="CCD11787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27320"/>
    <dbReference type="OrthoDB" id="1719476at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17251" checksum="AAEDBFDD6E1659D3" modified="2011-10-19" version="1">MGRTRTVTPHARMALTPQLTATLHHWRQHLLQGRAAKVSWHHASLPATNTAHAILSCVLHPNAHRNKSWSSCTARGSTLKQIASRAVKVQWPFLTVTRHSSPSGIHARPLHSLRKSKPSEVEAALRQYGPFDIAVPASSVCGDHITWLPSHREVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X6</accession>
    <name>F9W3X6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1124</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_27940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000490">
        <property type="protein sequence ID" value="CCD11854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27940"/>
    <dbReference type="OMA" id="HERYIVG"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389854" evidence="3">
        <location>
            <begin position="23"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="513" mass="56538" checksum="027C0234529DD4FC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H2</accession>
    <name>F9W4H2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000554">
        <property type="protein sequence ID" value="CCD12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14111" checksum="5C2717C3446BE37C" modified="2011-10-19" version="1">MLQALHSLFFLSQEFPSLPLRGPMNLITLTAVADRTHIFNATPPTHQLYKNPRNIASIINPAVLLTDKGKTQNFQHVRQFPGSGMKVAGEAPANIHPAVEQWGERIPVTEYTTLIHKLAHIPRSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4I1</accession>
    <name>F9W4I1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_29940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000559">
        <property type="protein sequence ID" value="CCD12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29940"/>
    <dbReference type="OMA" id="MLHGWIT"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389794" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="911"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126068" checksum="F0574EBAD39EA126" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4T3</accession>
    <name>F9W4T3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000603">
        <property type="protein sequence ID" value="CCD12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30870"/>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="547" mass="61571" checksum="A8F4FE801F4193EE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Y4</accession>
    <name>F9W4Y4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 1251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_31320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000631">
        <property type="protein sequence ID" value="CCD12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31320"/>
    <dbReference type="OMA" id="WRNYVIC"/>
    <dbReference type="OrthoDB" id="1607650at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030176">
        <property type="term" value="C:integral component of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PTHR13046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="305" mass="34312" checksum="B9B86CFF2B918385" modified="2011-10-19" version="1">MSDVGICVLLCGGFIGSFYVWRRERTFALSCLKDLQVASTFEPCCFESNNHTTFRNRLISFTGYTGVSLLLLEYLLRKEGTDNTPRGSSAVVHQLLCPGGDVKRCLSVTAKSALATLFLFAGPLLENGAYVFHEDEGIFVLRNLVVCPIGEEVFFRALLLHILLKRRSVMFSVFTSSVLFALSHSHHIFPIVVDEYQNGKQEEKERNDAQPMYWVRALKKLTPMYMCTFACGLLTGYYYSVCTNKNLLATIITHMLCNFIGPPTFRFITSNSCSHRLCYGGIYSSGVVGWLVMLRNVQKPLTGWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5A6</accession>
    <name>F9W5A6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000686">
        <property type="protein sequence ID" value="CCD12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32400"/>
    <dbReference type="OMA" id="RRFICAP"/>
    <dbReference type="OrthoDB" id="1657543at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="559" mass="64983" checksum="F662CB3268B7202A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B0</accession>
    <name>F9W5B0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000689">
        <property type="protein sequence ID" value="CCD12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32440"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="29810" checksum="4FDF5564835C7414" modified="2011-10-19" version="1">MRQPGGPDELHKLLLERVEELKYWKMWGVEQERNISSFKKALMMWPEIQWGPRPRTEVAREKFKCPYCDKTCQNVGWLKRHIRTRHSLKSESDVDAAADDPRLQCPYCGTAYGSVGWLKRHIQEKHARTPQLPYRDAGNVGVNCFLCNVTCGTADGLVRHVHARHSSGSGSSAKKVADALRLECPYCNKTYAISGWRKRHVQKRHAEKLQASYQDAVDDFLTCPVCPASRSTCGELWEHIRKEHRLGQWEEDMDSDMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5C0</accession>
    <name>F9W5C0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1307</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_32540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000693">
        <property type="protein sequence ID" value="CCD12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32540"/>
    <dbReference type="OMA" id="IDCGSAQ"/>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="73"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="323"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="896" mass="100297" checksum="828498B6AC91074B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5C1</accession>
    <name>F9W5C1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1308</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000694">
        <property type="protein sequence ID" value="CCD12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32550"/>
    <dbReference type="OMA" id="PMIAVEL"/>
    <dbReference type="OrthoDB" id="1291050at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="235" mass="25860" checksum="33BA04E95D74F359" modified="2011-10-19" version="1">MSLEELSPNYFTLSKDSPLREKVAKAYRWYSPKFSPHDVPRFAEVGSLTEKPDVMRAIRDFFVERYKKLPQPITHVLGFDSRGFLFGTMIAVELNASFVLVRKTNKSAGVLIKSEPYQKEYASETEEFMTIRSGVLNKDSRVVLIDDVIATGGTVLSGLQLCDACGATVVEVAAVLGLTFLKGSEPSHTYAGGRYSKVPFVTLVDESALTEENCGDVPGYTGPRTITCAEAKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I1</accession>
    <name>F9W5I1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_33140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000716">
        <property type="protein sequence ID" value="CCD12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33140"/>
    <dbReference type="OMA" id="AKCERTI"/>
    <dbReference type="OrthoDB" id="1418234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="327" mass="36253" checksum="22B34EA9E19042DE" modified="2011-10-19" version="1" fragment="single">MIREALNLYMKGGDPELRGLHRATSVVFCLWVFDTFVGTYSGCKILQFNSLVMLNMWVSLAAGVLCIKYCRAVSMLAQCGKSNQAGHLVGPQEHSSLVVEQEEEQSQQGVSFTFDEVDGFCFGARRLQTLTSFAIAVFVLFGCFTVFIEAIHHLKQPQAASPKMLLFSGVIHLFVITLYGAEIDLYDRISGVNFVQHEQNGLPTLHFSARQLMRRPQLLFSKNFIQQSKLVHCAVRAFAALSCTLLSLMEGVCGGSYLEIIGALALGCYIGVVAFRRMCQMWWLLLNNAVRHPGVAAKCERTIGSVHLTSGVMQVKSSCFWEVSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I8</accession>
    <name>F9W5I8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000718">
        <property type="protein sequence ID" value="CCD12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="108" mass="11828" checksum="814EB30C733F3ECE" modified="2011-10-19" version="1">MPIKAQFPRETHKRIIHSPCTQHIAGIGNSSAVILPSALVCGFSSILRSTVHAATPHLSQPPFNRIGRSSSHTATQTALTAYFHFTENYSTPSSNEHTQTHEHTSEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L1</accession>
    <name>F9W5L1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000727">
        <property type="protein sequence ID" value="CCD12463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33420"/>
    <dbReference type="OMA" id="CAAGSES"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="520" mass="57208" checksum="2AB78AF5B1BFC3A6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5M1</accession>
    <name>F9W5M1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000731">
        <property type="protein sequence ID" value="CCD12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33500"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22890" checksum="A53086AE6CFD65C5" modified="2011-10-19" version="1">MTPSTLSYLSFFPNPSLLPQPEGISMSNSPSSPSPEGMAQQDNPWSMEKDVVEVLLKNIGDPKKINLYRFLQPAYPFMHSYVSRFSITDFARNPWRCVGEADGREQVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQTRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W600</accession>
    <name>F9W600_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_34690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000805">
        <property type="protein sequence ID" value="CCD12603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34690"/>
    <dbReference type="OMA" id="RWLYPGS"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="43797" checksum="DCC085CEB60F26E4" modified="2011-10-19" version="1">MAKNVRMRVMQKPRRPTGKLLLLCAGIVSLIIILCVLWGTSGCQPNTATEKDSLTPINYDTYLRFIPPDVVSTWKAREFLVVMGIPSVDVEGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRKRIGEGGDWGRAAEVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRFNSYTRFWRSGELWYALGYCTTLSKDAAQAVVSYEPLKRLVRTPYSTWKFFQFLDLAMFYEDVMVGLVLREKIKLDHLVIVNVKECRFHDVPNNLERRITNNSVVLHHIRESYYIELLNYFSLNATPPAPSPIRWVNGYTAILPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W602</accession>
    <name>F9W602_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000805">
        <property type="protein sequence ID" value="CCD12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34710"/>
    <dbReference type="OrthoDB" id="1096950at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="27961" checksum="BAC1A08D674D82EF" modified="2011-10-19" version="1">MPMAGADLVELLQVCVRGAMAAQRYIILELLQLDSSDAPRRDVRIADFEPQSLRMLRDRLRHVVTVGVKGQLAHKEGTAANDLVTTADIVTQTVLERALADAFPDMPFTLVGEEDANTIAAIASQVDDCMRRFLVADFPIPLQADLNRHACAESRLICAETYEELRSRIGVFLDPIDGTNCFVDGHWTAPLTLVGITLDGLPVAGVVNRLFYCTIDDVTCGSGAECGSLSYVWNDASTGPFLLHEGRRVHVGARHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E2</accession>
    <name>F9W6E2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000852">
        <property type="protein sequence ID" value="CCD12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36010"/>
    <dbReference type="OMA" id="RNSEATC"/>
    <dbReference type="OrthoDB" id="992858at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="49068" checksum="0CC2E8C551D96D75" modified="2011-10-19" version="1">MKKISRTSTIRARLDIYLPIFPDTLFCMMERQRCLSPHSQMESKKFPIVICISGGAWIVGCYLWGALVARLLAACGYAVFCPDYRNFPQSDMEGMVLDVSDAIGWVVRNASRYNGDLSNVTLTGQSAGAHLSLMSLISQAQLSAYASSGATPPTAAAYNVCRYNPRVSIQRYIGLSGIYDLQGLVPHFHSRGLYSSVLHKITGGKEKLARFSPAAYFDPQLCNETGETLPENIFDFLPAYMYFLHGDADCSAPVSESANIAFAMRDAQRRMARNRRKAGLSSSSTDAPEQTVFRGGKHGHGYGDVEDGNGSVCQLLDGEGRQCLSVASGQGEVPPAEIRWVKIPNASHTDPIVEEILVARRSSLVEFILRQEDYLAPRRFCGSRMQKEIDENDEDEGAFAALRVPLADFGGSASGVTPVMLPDAILPTCVPHESRPLLMRVASYVIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E3</accession>
    <name>F9W6E3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1451</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000853">
        <property type="protein sequence ID" value="CCD12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36020"/>
    <dbReference type="OMA" id="WKIDVES"/>
    <dbReference type="OrthoDB" id="631093at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="550" mass="60041" checksum="CA49E0FC8E8DBE85" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H0</accession>
    <name>F9W6H0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000869">
        <property type="protein sequence ID" value="CCD12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="16699" checksum="A87F39D9D0BCE479" modified="2011-10-19" version="1">MRKVMNCAPLKACLALKKKKMHKVEYKNAKKKRENKKKTTEIKTFGQSIHSTVKFFFVVETTKMTQTHTEDVITQKLEIMPFSCGLVFPFHFFHFSRSALIFHAFQLLIATSHTPEKKEKQRRYKHKHRKKRKKEQRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H7</accession>
    <name>F9W6H7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_36340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000873">
        <property type="protein sequence ID" value="CCD12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36340"/>
    <dbReference type="OMA" id="ANENMIH"/>
    <dbReference type="OrthoDB" id="255547at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="719"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="863"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="957"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1023" mass="113276" checksum="A065A57A954A5C79" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J4</accession>
    <name>F9W6J4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">WGS project CAEQ00000000 data, annotated contig 1482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TCIL3000_0_36490</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL3000</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000887">
        <property type="protein sequence ID" value="CCD12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36490"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036862">
        <property type="entry name" value="Integrase_C_dom_sf_retrovir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001037">
        <property type="entry name" value="Integrase_C_retrovir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003308">
        <property type="entry name" value="Integrase_Zn-bd_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010661">
        <property type="entry name" value="RVT_thumb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00552">
        <property type="entry name" value="IN_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02022">
        <property type="entry name" value="Integrase_Zn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06817">
        <property type="entry name" value="RVT_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46919">
        <property type="entry name" value="SSF46919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50122">
        <property type="entry name" value="SSF50122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51027">
        <property type="entry name" value="INTEGRASE_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50876">
        <property type="entry name" value="ZF_INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNase H type-1" evidence="12">
        <location>
            <begin position="476"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase-type" evidence="11">
        <location>
            <begin position="610"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="664"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase-type" evidence="14">
        <location>
            <begin position="830"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Integrase-type" evidence="9">
        <location>
            <begin position="830"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="917" mass="102567" checksum="EE5CF80278B95DE4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6M3</accession>
    <name>F9W6M3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000896">
        <property type="protein sequence ID" value="CCD12830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00310"/>
    <dbReference type="OMA" id="GRAFCFP"/>
    <dbReference type="OrthoDB" id="883398at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="3">
        <location>
            <begin position="209"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37561" checksum="7F892BCB61D9F682" modified="2011-10-19" version="1">MKGTHPVLVVPCRRGGIPYLTPEQARDILEEEERVVSLCIFDAHEYRTVCASTQRGFTEFCGLADFKLILTVRSSLVGMHASAPASDTAVSGDHGKGRLSFHSGQWLELITSLRPTMAVTLYDSVPLHELNPRRRKTTSNRSLKWANAADSLQHTLGCELIKPYGITGEKATYVYAGNLCQNELIEQYYCHLREAVESHQVMAPAMSVGAVLMALMAGVTLIECPLPWVLAERGVALTLNLKPVPGETPRRYESQIDLNDPYFAVDIGPLSPSCVCYTCKRHNRAYLHHLLTVQEMNSDILLVIHNLSSMVQLVRQYRRSSAEDRHTLLSWIFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6S1</accession>
    <name>F9W6S1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000923">
        <property type="protein sequence ID" value="CCD12878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="16328" checksum="6A5DBE9B282D86CF" modified="2011-10-19" version="1">MQKKKHLLLFTLLFSFFFFHLLLLTLFVKFGNNSKVPHSFSSSLKLARKKRHGETRDSRIARGSRRKHYIYKYINLPPLLLHSTDPLPTRLFSSLIVVASYAAPHTQTQGPSCGRSSCGNPTGHSQHDRLCHNVWPDVPFPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W702</accession>
    <name>F9W702_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1544</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_37790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000957">
        <property type="protein sequence ID" value="CCD12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37790"/>
    <dbReference type="OrthoDB" id="1489331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="PTHR10676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MT" evidence="4">
        <location>
            <begin position="117"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="641" mass="72672" checksum="986F4CCD21328784" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W721</accession>
    <name>F9W721_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_37980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000965">
        <property type="protein sequence ID" value="CCD12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37980"/>
    <dbReference type="OrthoDB" id="1669367at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389879" evidence="8">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="39"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="43242" checksum="F89DC13E8EFC0771" modified="2011-10-19" version="1">MMIEECSVWWIIVGLFMTWFPVSSESSLYPKAIPTEAGESICTLSRKLKEVALWASGKVEALRKESDVHASKILDWQLYFHESLECDVNQSILEEIRTALGEANQEIQKLPKKAIHAGALAARSAGRLDEFITVFSNAQKESFMDKVNYCMAGGGRPARRRDLIECFPTGSRLEMGEANLAKIPESTASRDEPNLAYVIKNITHSSLSAHWHRYALDSDAECNLIKGSSGGILSGELHDKLWWGGGILTIGKGFTGEMEKTAFSAGEITNASKDSGSNKAFWTERPSAKIPHLQKTLAAFQAFKDAAATITQKFTEIQKIGKKIEHCLSNETMEEGPTQSCLKSAVKLNAELQVANALLARYHKEKGPLPSGSVLKMHQSVVNVWYVFASML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7C1</accession>
    <name>F9W7C1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_04130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04130"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394736" evidence="4">
        <location>
            <begin position="35"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="107"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="47016" checksum="0C1C8FE851CFCFD4" modified="2011-10-19" version="1">MLNKLIREVKNRGLFVNVLLATVVICSWCGDAAGQPGAEVKSMDNAEQFALLCRIYNLAKNPPIHHVDLQDHVKIVEEIDTINSSFSESKLLNETEMTVNASLTALKPTTTREAAVAQAILRRISQKAHNILDDIRRLNTTSAIENVKAVFAQVIFGGGGNESDLDKSTLSEVKGRADACGKSGLQSKGQSAGKNLVVDFFCLCAQNSDKNNGIENVCGVKVGSKDDNHSWGANTVLGSPSLWASIKKGCGNLFHRYPNSTKEGHEVLGDFLTHLKSGGVYRWGKNSILGSNRKAGMLGTSVGGDTGTSGNDLICDGKKGYAKGRQPPGGVCVYYGPDKWEENIEWLKKLKTALNTVDALNNQTTTIQRDIQKLHMLLHRAEQIYETTKVITEVQNPVMPTSLHTTAKRLTAYSAAWSNSPHAHFILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q8</accession>
    <name>F9W7Q8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001066">
        <property type="protein sequence ID" value="CCD13230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04350"/>
    <dbReference type="OrthoDB" id="1696354at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="23629" checksum="1A35499D05C0624A" modified="2011-10-19" version="1">MAYEGVSKVCGVSVGAGAGLGWGTSLYSTAAMWDEVKKGCEEISPHSTKSTESGHSLYYEFLSKVTEGGNVKIKSSGSGRNPGMLGTAVTETEKANFNCNGKASSVRDPGSGSCIFYGDQKWEENIEWLKQFKTGLEIIDKLNNKTALWKYQLTTLQRRAKTIYEKEKAASQLEKEDMEEPTAAPHPNSAKNETVDCTTRSHRHSLLELALFLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7R5</accession>
    <name>F9W7R5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001070">
        <property type="protein sequence ID" value="CCD13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13136" checksum="9C3C320EBCDA6F81" modified="2011-10-19" version="1">MHVCRPNSAANGCHSVAPQPKGGTVVGKNSHQMARSTAGLGLSPHFRNERAPGGLCWVRVEHSKKGPLKGKLLTEGEVFLKYAGSLRVAHDRILTVISKIELPHRGIKEWTKCLRQWGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V3</accession>
    <name>F9W7V3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1658</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001084">
        <property type="protein sequence ID" value="CCD13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40440"/>
    <dbReference type="OrthoDB" id="1494426at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="261" mass="28623" checksum="056DC6E8B2685D36" modified="2011-10-19" version="1">MGETVSKMCEAAQGTHEDLNAYNTMSDIVLSRIQRHEKHVKQLTEKIEMCVDTQREALAAASRQLKNERAALKTVLLRSGCQPGGSPPGRWQSVQPTVTSPSEAAAFGDVSHHVDSTCAPELAITPAEKKMEDNCEEVGSPLNTFLPPACWDSSAGCTSSENLLELPVPYEGPSDQVCVCSTIAQVPLHELANNLLRSRRQLSLVSQLSRRCPNAGELKAALLEKEMGDVLNVFKALEHRYCSRKERFVSRCFIESLSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y4</accession>
    <name>F9W7Y4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_40730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001104">
        <property type="protein sequence ID" value="CCD13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40730"/>
    <dbReference type="OMA" id="QEMGSVD"/>
    <dbReference type="OrthoDB" id="974610at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033257">
        <property type="entry name" value="Eco1/CTF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="PTHR45884:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_13" evidence="3">
        <location>
            <begin position="257"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="34696" checksum="0C8EA3DA10E384B5" modified="2011-10-19" version="1">MNSFLSTFCIPRSSRLRPAPAAAGPLQVLRPSHIAEHCCHGRMRGSTVPDGGSPAFGGLSGTRRGKRARQSNADEAGGCGVSLARDVVFKLPRGKLSKWLNSPPCCLCDVRPSSASYSNNALPVQCATIPGFFAPSSASAACKPRLRCVLQRALAEVRQEMGSVDNIPSDSLLVIATPSEEQTPGLCESAGFGNARALLGLCVARELSMAYRLHCEPSLEPDKRETCGSGAPRLEEECCHGWEKCAMRVGDTRCVGSAFCGVQLVWVAEQYRRSGVANALVDVARRHVSYGFDVPACQVAFSEPTTLGALFARRYSGRPDFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W839</accession>
    <name>F9W839_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001131">
        <property type="protein sequence ID" value="CCD13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41220"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394760" evidence="5">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="38926" checksum="8D5D12EC73C413C2" modified="2011-10-19" version="1">MEWGMWRRLLSFLFFVGKGTLADGSNSVVFDKLCSIAGGVSTLMEKQKDSGAKTPLGQALYGEDGIVSFDKDGSVLTVYGCGFGLVGRSEYCSHMRGGVLARNGNGCFSHSLLGTFLCLCTNGKKGDKDLCGLKNVGDGAIWTGDINGGHEKSLLKKVWGEIKVQCIEKKKSTLSISEECENVENAVKKIKEQARQSTINGYVTLGGTSTDGICSGARPGDACVTYTGSGNAPDIPWVTKILTSIQSLKKSNSEQQTSHQNSNPPTPPGTGQSHHYPTAEEYPTDHSTDSDDKQEEESEKEHMQNGSQQDPFEASRQKRKKSSHKYTEEIMVTPTALLHKDDGSFLHQPSWLLSAVVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W869</accession>
    <name>F9W869_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal_S10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_00370</name>
        <name evidence="6" type="ORF">TCIL3000_0_00390</name>
        <name evidence="8" type="ORF">TCIL3000_0_02410</name>
        <name evidence="7" type="ORF">TCIL3000_0_60110</name>
    </gene>
    <organism evidence="6 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001142">
        <property type="protein sequence ID" value="CCD13395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001142">
        <property type="protein sequence ID" value="CCD13397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001935">
        <property type="protein sequence ID" value="CCD15505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002687">
        <property type="protein sequence ID" value="CCD17366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MANIKKD"/>
    <dbReference type="OrthoDB" id="1454256at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="4">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13254" checksum="B65923FD706CA14A" modified="2011-10-19" version="1">MAYVKKDQGPALENQRVLVKMTSRNANAVEKVMATLLTHAHNEHVEVRGPVRLPTRRLRITTRKTPCGNGTNTWDTFEMKIYKRLVDLRAPTELVKKITSFQIEAGVDVAITIPDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B9</accession>
    <name>F9W8B9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1726</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_42000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001160">
        <property type="protein sequence ID" value="CCD13451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42000"/>
    <dbReference type="OMA" id="HKETNQF"/>
    <dbReference type="OrthoDB" id="963519at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="270"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="37582" checksum="03A0B6880F595F12" modified="2011-10-19" version="1">MYAKPDASKWKLSDFELGDTLGVGSFGRVRLAKLKDTSEYYAIKCLKKREVLKTKQVQHLSQEKQILMELSHPFIVNMMCSFQDENRVYFVLEFVVGGEVFTHLRSYGRFPNDVAKFYHAELVLVFEYLHSKDIIYRDLKPENLLLDGKGHVKMTDFGFAKKVPDRTFTLCGTPEYLAPEVIQSKGHGKAVDWWTMGILLFEFIAGYPPFYDETPLRTYEKILAGRIKFPNWFDSRGRELVKGLLQTDHTKRMGTLKDGVADVKNHPFFRGANWEKLYCRQYPAPISVKVKDPGDTSNFEKYAESDDKQQHPLVASQQMEFRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8P5</accession>
    <name>F9W8P5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001194">
        <property type="protein sequence ID" value="CCD13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43220"/>
    <dbReference type="OrthoDB" id="1719920at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17662" checksum="7F4C04BDFE8E0DA3" modified="2011-10-19" version="1">MDTCVSKLFACQFVLHLRRSVECLGFFKMGISFLPTRKLQGYSTLAGFSKISTDNIPRPVLKALSKRLFLFEKRRKCKPSDGSTNWVLQAGAFPILGVKGVARVINYDTTVIPGACFVGDICAFFLFYWKRTILSYFLACVKHRQSIECSFFLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Z5</accession>
    <name>F9W8Z5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001245">
        <property type="protein sequence ID" value="CCD13684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="946207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15969" checksum="1796181FEF4C80B0" modified="2011-10-19" version="1">MKSVFDIARSHITLPVSKDGSALRQVLRDWLSYSERVPLQKKPAFPAELSVTVYAPRGGTPHEAQIARPLRYTRRVPLLLWTAVLPWEVQRGLSMSLLEPPEQDTVEEGVRKNLRIPLGMTARLLSRKRRRRKRTHLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W904</accession>
    <name>F9W904_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_44270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01001248">
        <property type="protein sequence ID" value="CCD13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44270"/>
    <dbReference type="OMA" id="RIFHNEV"/>
    <dbReference type="OrthoDB" id="632665at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="101"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="379"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="616" mass="66417" checksum="1B70B5E46D2DF6BF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W908</accession>
    <name>F9W908_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001252">
        <property type="protein sequence ID" value="CCD13697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44310"/>
    <dbReference type="OMA" id="HEENCSS"/>
    <dbReference type="OrthoDB" id="1619604at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390021" evidence="1">
        <location>
            <begin position="22"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22689" checksum="1FEF857B330CC2E5" modified="2011-10-19" version="1">MGPGSRFALLFLALMVCGVWTGNGLTMLFKARYCVGLKVAYARLNVRLLNVWKSVEYSLEKAVSAKQRCGKILKFLGNEDKLDVVNIGKAKRVEESYHHISAIEHRIAILEKSVHNSFNKVLDFCDNSRVIGKFSLKLMFALKIGYREANGSVLDAEALSITAQKRSAEAHEENCSSEHFWEVLDDPDDDQHLVNGSEVTVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W928</accession>
    <name>F9W928_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13891" checksum="2088A7724CE201B3" modified="2011-10-19" version="1">MQFEEEFHSTGNDGNSMPHNTFSRYYCFHYCIHSQKIPLLRGNIFSPRNKCPCYGNPLWGYVWSDHGSSIIKPLSLRSTLFLGEVFGNNLEKGFMSEAHWSSSWKILGDLFLGYVWWWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W947</accession>
    <name>F9W947_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_44450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001260">
        <property type="protein sequence ID" value="CCD13737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44450"/>
    <dbReference type="OMA" id="CISIFME"/>
    <dbReference type="OrthoDB" id="261410at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="660"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1140"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1501"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="795"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1503"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1523" mass="165107" checksum="59D2DE73D1E853CC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9D2</accession>
    <name>F9W9D2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001297">
        <property type="protein sequence ID" value="CCD13832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45280"/>
    <dbReference type="OMA" id="AVYNIFI"/>
    <dbReference type="OrthoDB" id="1453510at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="577" mass="64307" checksum="9C7BD9E7AFED1434" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9L6</accession>
    <name>F9W9L6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1873</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001323">
        <property type="protein sequence ID" value="CCD13918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46040"/>
    <dbReference type="OrthoDB" id="138107at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="644" mass="68697" checksum="F3D93B8138BA327C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M5</accession>
    <name>F9W9M5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1880</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001330">
        <property type="protein sequence ID" value="CCD13929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46150"/>
    <dbReference type="OrthoDB" id="1689848at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="265" mass="30394" checksum="D255974CC50BAB2C" modified="2011-10-19" version="1">MGSSKSVMLRQSSCINAIVNLHTCDTRARGQAQQQATLAPQFRAWRLLLLWFSIFCNLFLVFVLFSFFRKGFLRCIFYLALCVDGCVVIFFLFVSDVGVVFSLCRCFFSFLLICYLFVGVTSALDFTLYFCLFWHIYGGLPYRGETRVVAICLGWSCGAFRLLSIVLSLRRANHLFPNECKRDNRCCTVWQAYYHHLFVCACFLYPRCCCEPWCFVCLLSLRQFPEHIRLSSITSLFDPLGCHAWIPAGTFLHPGQLAELPAACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9S7</accession>
    <name>F9W9S7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001342">
        <property type="protein sequence ID" value="CCD13982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16262" checksum="6639E8A6CE3A4D14" modified="2011-10-19" version="1">MAGAVRGFPSTQRNDSAGALCRCGPRILPKSNDNEWGPPTVPKLQTYKRSLSITLLRGQYGPKTLGSLCFAHYFSYELRRPGKKSRVRTGWAGGPEWFRSKLSKRGKKLSLISRGSKAPSFSIRQTEGLKIITSQAVIHVVLLVSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U2</accession>
    <name>F9W9U2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1897</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001349">
        <property type="protein sequence ID" value="CCD13997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46810"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="11" mass="1288" checksum="2A66FDE027245408" modified="2011-10-19" version="1" fragment="single">KEIGRNLLNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Y6</accession>
    <name>F9W9Y6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001364">
        <property type="protein sequence ID" value="CCD14041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47210"/>
    <dbReference type="OMA" id="YAKQIGG"/>
    <dbReference type="OrthoDB" id="804336at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902445">
        <property type="term" value="P:regulation of mitochondrial membrane permeability involved in programmed necrotic cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="PTHR21052"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="305" mass="35034" checksum="AF23C187BCB98C74" modified="2011-10-19" version="1">MKRLWDGAKHLLSGGSLGYLACSEPHQPFGDEFGLTIFPDYVQIREKMALRSGYVDIYTKRSASIRLSDGRFQLPPLPTGSFTPLLDRIEQDGIVPRGWLNNQTANLYEPGDFIRAHIDNLFVYDDIFAVVSLGSNALLRFVHVQNGEELDVVIPDGSLYIMSGPSRYVYFHMVLPVEAQRVSVVFRRSILNSDGGFRPVTTPLGDLMPYRSTQILNTLYAKQIGGVRIVMDDSYLEKEEIGAFDTARWVKGLHPLRDWTLLSQLDEDEIRVQELQEKRYLDVDLSWRFTELKHRYKELEEMLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA78</accession>
    <name>F9WA78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1946</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001404">
        <property type="protein sequence ID" value="CCD14134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47940"/>
    <dbReference type="OrthoDB" id="1694509at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="247" mass="28035" checksum="98465F689A2F5C73" modified="2011-10-19" version="1">MIGVVMASLPVPHAGSSYPQPIPPEPKRSPLYTQQEFKRCPALPDREAVRVPEDPFRARIQIVSRGASFSWVSRLPEKRKASCRKFGIFSKRLTNQGADSLQRSSVPPLLLSSTASVWASSSPCSRGPKGERASWKEPTNVGRMMGRAPPRRPFCRTACRRVRESKWGTPRGQSSCTSDRWRRTDLGPCHRNGDSKCLISTWVPRGTGHEYQLQPDQRGRRWNPRSQSQRSAFVGRRHDHHRESVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD6</accession>
    <name>F9WAD6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001417">
        <property type="protein sequence ID" value="CCD14197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1554256at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24407" checksum="3B43E62DE9E7DE1F" modified="2011-10-19" version="1" fragment="single">MTPAPSVEPGARWGNSHGLYDSQWENTYKFSGAKAAATAAFEQAAAEERSNDSCRDVRAKLLPSESADSGSLQRLSSAEEYSCTRRNVTLLPRFQAYEIRETRRISPKREPAFSATVVYASRGTPSPKRSVSSGVRTPSGETGQESCQRATPRTVGGPLARGSAEEQDVGSRRASTTPRSVMMRDEATTTEASLLRESAASQSPYPVMPKKSMHDASTMTGESFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG2</accession>
    <name>F9WAG2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1971</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_48710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001431">
        <property type="protein sequence ID" value="CCD14224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48710"/>
    <dbReference type="OMA" id="FRETFIF"/>
    <dbReference type="OrthoDB" id="996164at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="531"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="67634" checksum="6F643F799CC94BE4" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH7</accession>
    <name>F9WAH7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1976</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_48840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001437">
        <property type="protein sequence ID" value="CCD14239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48840"/>
    <dbReference type="OMA" id="YIVVRSH"/>
    <dbReference type="OrthoDB" id="33214at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="SSF81837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="2209"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="2360"/>
            <end position="2656"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="2856"/>
            <end position="2888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="3044" mass="338038" checksum="7ADB0F6E60401AC7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI0</accession>
    <name>F9WAI0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001438">
        <property type="protein sequence ID" value="CCD14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48880"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20095" checksum="E8856FB40CDB36C3" modified="2011-10-19" version="1">MSGSPSSPSPEGMAKREDQWSMEKDVVEVLLESIGSPDKIHLYRFLEPAYPHMHSYVSRFSVRDFARNPWRCVGDADGREKVWQHIPRLLWQFRVLALQLVYYAGPLESWGPRGWEVWREFLKVDETDPEILDGTVWESYRIPPQARGVLEAPYPIGHMGPIPMQPPPEPSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI8</accession>
    <name>F9WAI8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_48990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001439">
        <property type="protein sequence ID" value="CCD14255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48990"/>
    <dbReference type="OMA" id="EHFPIEN"/>
    <dbReference type="OrthoDB" id="1422995at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SSF47769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390053" evidence="2">
        <location>
            <begin position="26"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="322" mass="36050" checksum="583830E9E81CFE67" modified="2011-10-19" version="1">MITYRGVDALFVLLLTFQWAHVSQAETVKVTASPIGNKPVNLWSVTDVEYWMNNTVGYPEYSGYVRKHLVDGPTLMEMTPADFEEHFPIENSIHVIKITAHMKLAKGLCSCGEDSAQGDFWSYFKREQFRVFVVGATSLFFPRVSMIYTFLSDKQLYGMLLGGGSRLDEVAMAAGAGSADSKDTHNVPLLYTLLFLIFLIAAPDIFMALQACRMITTNYFIMPLVVVHFLFQAYGEYILLVLIYSGNAFPPGTSLARKLSLMYSYTLAIPPIVFVLYFFIPYFLQVIVVCFLLLNVLIMCIGVITVHLGGARSAEGPRDKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ0</accession>
    <name>F9WAJ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001440">
        <property type="protein sequence ID" value="CCD14257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49010"/>
    <dbReference type="OrthoDB" id="1718636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18682" checksum="7C248400ACCB379A" modified="2011-10-19" version="1">MGVKAYLSATSKTISKFHTSLPSSILPCFASARLSKVSGRKQSWRELGKTQAALRHFFSVSGGVFSQRVTMATMWPSQGHRPVQNSKTINKSKAHVISFLKNKMKEEKIIEWRISPTVKKRCTRWVLAAKKHCAIQMEREMIFLLFLKSIISEKTHPNVGYLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAQ8</accession>
    <name>F9WAQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001469">
        <property type="protein sequence ID" value="CCD14329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="14160" checksum="95DB7E3FC0129585" modified="2011-10-19" version="1">MCLKLRSESGVRQLTGNIRQKTHLHPEALRAVMPTNEVGFCQVRLACPVKEYHKQLPLDPCRWGCSNRQERPIETRHDRLNRPTAAALACKVSWPLYQMSRSRIMPSPLYFPPPDEIAHAFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB56</accession>
    <name>F9WB56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_50960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001534">
        <property type="protein sequence ID" value="CCD14487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50960"/>
    <dbReference type="OrthoDB" id="1665089at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390092" evidence="6">
        <location>
            <begin position="22"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="19"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="95"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="417" mass="45554" checksum="CE2AB56B3733BB8D" modified="2011-10-19" version="1">MECFVRVIAVVIFNLLVGVKGQGQVNVQGVDNAEQFALLCRIYDVAKNPPIHHVDSQDPLMIVSEIDALNASFAYEKHINETENVGNSSDAQVKPTITREAAVAQAILSRITKKANAILREIIKVNTTRDIEKVKADFAQVIFGEGGNESDLDKSTLSAVKGRAEACGNSELSNKGDSAGENIVVDFFCLCTQRTNNAEGIDNVCGVQVGGKSKGDYHGWSDAAPSGSASMWASMKKGCGNLLHQPHKFIEESYEVVEDFLKHLKTGGVYRWGSGKDSDRKPGMLGTGVGSNSGNGKSPVCDGKKGGRGQQPPSGVCVYYGTESEWETNIPWLKQLKTALDNLAILNNQIATIQRDIEKLHMLLHRAEEIYETANVITEIQRPIVPPNLQSAAKRLTAYSAARRYHPYHFILLWVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBA0</accession>
    <name>F9WBA0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001552">
        <property type="protein sequence ID" value="CCD14531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51390"/>
    <dbReference type="OrthoDB" id="1676749at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="321" mass="35435" checksum="2DF0A677EDB7459B" modified="2011-10-19" version="1">MSFSQTLMSSEGKRPTNWAQMQCRRRCRPFCRCQLELLLVGGNQRTQSEFGVHRSNRTVKQRRVKRSSSAVGKGDSAILLNGPFELLEPMVFCASYPCGREDPRLMRRIKGKLFLALSGAGGSDVEPSVDSLQPRDHPERTAVQSSVDISEERGAIPRTCSNPFSESTFIHSPTMPIFEVLAPRFSPHRNIPDGLCGEQRSFRGNLDSTFSTDGTPQRSTNNRVVRLNSRGSHGCIRRESGQPSLQRLSRRDRLCAALGLRSLRDCCGDVLLGSTVLQDYSSPFSSLRASTSVAVDVRLSSCDAPLDTLMTSVETSSTRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBF8</accession>
    <name>F9WBF8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001574">
        <property type="protein sequence ID" value="CCD14590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51940"/>
    <dbReference type="OrthoDB" id="1664274at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="464" mass="53559" checksum="2C1704AEB01BAEAF" modified="2011-10-19" version="1">MSARKREQQQHQDPQMQVVPAQQIIPPIIQEPQTQGEVQIEQELFPLPEQQPVPVTQHPCQWKKPGYSYMHDGLASTLPYHSEDHKLRLNQAKQLDAVNNSSRFTQLCIEYPDATETNRSTRDGFPPRFLRLTRNAEAQRPLQINPVPIGTIVQQPNGTPQILMDPSRSKRLGIKVLETEIANRRIMNLHNARVQLRTFQSVQTDIEFTDEMQVALRTFNGTLYVLERYGPAITMEGILKAHGASWEKHLEWLGIKTPTETIGHEAQGRIDQYRSAYQAACFWADHHERTIYGLAGPLGETIEPFSFEDYDNMFSVFVTYVLTIIGKIHAGRVIDPKEIRNRYAEGIKDELQQTIDEHINSFVSRKYSRTASSRRPMIPKGTRVAGKGYYIGSGRRHRTYSTESRKGRNIGQQYRKYQKQDSYKSLRRTQRTRSKSARRRAATPKPKNAKDRVRFAETPPRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH5</accession>
    <name>F9WBH5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52120"/>
    <dbReference type="OrthoDB" id="1710753at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21093" checksum="205C4A53ACB08353" modified="2011-10-19" version="1">MSPVRQSYSRPIHTSPSISLCPTLTAASQVVAADGRLCNAPRQMVRGSHISLAGLKLTHIIEHSARLSKAFPFTTSGTFSGSHTHTYTAIGMPHAHQWMRPQGLTHLLPGDTIGSQHITCHSHLRDSSGHIKHMSDTMWSRTHSQVPHSSLVTEHIGLKYLISTSLCPTRQIHRVPTQHGTATRKSNGKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ6</accession>
    <name>F9WBQ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001613">
        <property type="protein sequence ID" value="CCD14690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52840"/>
    <dbReference type="OrthoDB" id="1725433at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17225" checksum="7DB2F49578BFE130" modified="2011-10-19" version="1">MAPLACGMSGVMAGVSHLVVCPQAVAFFSGGSRALREGTESERHGHTSGIMKALMGLRCLLEAYSLLSLRAAADVTTSLLDLKALFPHVELPCEALRLFCCRATNSDEWRELSPVLVSGVSRVSSHLSVRCVARAARAVFELTNKVLQQQWQDSHGTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ8</accession>
    <name>F9WBQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001614">
        <property type="protein sequence ID" value="CCD14692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52860"/>
    <dbReference type="OMA" id="RPTRFYC"/>
    <dbReference type="OrthoDB" id="871941at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027714">
        <property type="entry name" value="Fyv10/MAEA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="PTHR12170"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="PTHR12170:SF2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="641" mass="70469" checksum="6590ACF6EA49CEBE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT6</accession>
    <name>F9WBT6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_53150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53150"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394661" evidence="6">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="47"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="37908" checksum="D52F84614689E7E1" modified="2011-10-19" version="1">MWGNVLIVFILSHYSVKAVNCHNEVEQKLLCDIFRQSGRVLQKFEDAELIEEAIYGPTKRNAQIINFGNVTLGTSCHTPVLRDAFCRYLGGERVENGCFAESLLGTFFCVCAPGARRGYVDKLCGVSIKPHVDSWFGSIPLGQDKIEELFDSVWGYVIRNCTGVSESVGSGNEELEKLRKAVEDVENTIKQDRNSFYYYLGGSAWKDCSGLNGRDVCAAYKKKDGSDSKAHIPWVEKIKEAITQLQKVERERQDLDFMERTTGKPGEGTAAPIPRAGEGNAELTDQSEGIVTPPNSNETPSKTKISAKISPLSDIPHLPTYFNENGSPLTNQKWLVIAAFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCH9</accession>
    <name>F9WCH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001725">
        <property type="protein sequence ID" value="CCD14972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55400"/>
    <dbReference type="OMA" id="DSCAHAS"/>
    <dbReference type="OrthoDB" id="1738906at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18160" checksum="A3E7FF71FBA84445" modified="2011-10-19" version="1">MKQSALLWLKEKKNHANGIPEDDEERLCRLKEHCRALSVSCAKPSAAVASLIARTLLEQNVTLLDQVDRLGKSAAEEESRQLKQQQLLQKLSNEVLELREQLAVSACDSSRVELQRQEQLQRDTLCIHESDARVGLLCSFAHVALRSARWNTRMMRRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCU3</accession>
    <name>F9WCU3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001764">
        <property type="protein sequence ID" value="CCD15091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56540"/>
    <dbReference type="OrthoDB" id="253527at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MKT1_C" evidence="1">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20651" checksum="30556E8D43D33F57" modified="2011-10-19" version="1">MTPDAVSPRDTPCDVIFASRVLSIIPLNVAGPWTAPVDAELAAFSMLSRMISRSIRQLLEAITTLMFCKGRTAVPLHMIGEIQQGLPFSTPVEFGSGVLVEYMLMKDKCTLKDLEDAFPECTYLRHDLATLFYFWDLAVQVLHRIETKENFCVDPACLVSANERMKKAQKNLNIHTGMRETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCZ4</accession>
    <name>F9WCZ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001794">
        <property type="protein sequence ID" value="CCD15142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57020"/>
    <dbReference type="OrthoDB" id="1730610at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="22791" checksum="A2691B2A0F11C525" modified="2011-10-19" version="1">MCGTCSGHFFWFTNTFFTKKISGTFLKNKNKFKNFWKNLVTGSNSHMSNFFALGAIFPIFQKTKKIAKKRQNAIKKPIKPFFDVRNVFRTLFLVYNTFFTKKFSGTFLKNKNKFKNFWKNLVTGSNSHMSNFFALGAIFPIFQKTKKIAKKRQSVIKKPIKPFFEVRNVFRTLFLVYQHIFHKKIFGHIFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD63</accession>
    <name>F9WD63_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1171</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29420</name>
        <name evidence="3" type="ORF">TCIL3000_0_57580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000543">
        <property type="protein sequence ID" value="CCD12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001826">
        <property type="protein sequence ID" value="CCD15214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29420"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57580"/>
    <dbReference type="OMA" id="RCEHAVE"/>
    <dbReference type="OrthoDB" id="1316131at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="25084" checksum="85B9A0A075C8521E" modified="2011-10-19" version="1">MALQLNKDKYGTNEFNMSSLVALCSNCASLCLERTERAMENMSRAPRGWEAEYTAVARERQREDLTLCQSHCARVASVCPAPEALERFEAVGHRTAVEKPVADGLPTLQQVSRCEHALMDFTQVLFSLAHKPSKIVFEKLNPKTGERLDDEVSGGAAAGSEKSVLSGRSFDETILNRWSSSKREHEEMEKLGIVRSPADAASLKRKLERQGEEQSTEKKGTTPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD74</accession>
    <name>F9WD74_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001832">
        <property type="protein sequence ID" value="CCD15225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57690"/>
    <dbReference type="OrthoDB" id="1712480at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18962" checksum="6B03EE93BF7D993E" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFATIISVSFLVIHHPARCKTVLATIISCFSVSFLVFHHPARCKTVLATIISCFSTSFLVFRHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDV8</accession>
    <name>F9WDV8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001917">
        <property type="protein sequence ID" value="CCD15463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59830"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20127" checksum="77EF9F2008F53564" modified="2011-10-19" version="1">MSESPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPFIHSYVSRFSITDFARNPWRCVGEADGREKVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPPQTRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE45</accession>
    <name>F9WE45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001951">
        <property type="protein sequence ID" value="CCD15551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60430"/>
    <dbReference type="OMA" id="THRNMSS"/>
    <dbReference type="OrthoDB" id="1708599at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22052" checksum="3EB8CB82658F0073" modified="2011-10-19" version="1">MSARDTETKDEQRPERRVWPLSDERFAAAEYHSLVQKQLELLHNLPLLTARALQAEDRNDFYGRSGCTTRDAAGEQFGALAALGQWVSEGSVGASAKVTCQHTSVSVCGEDVRSVLLREISKRQRACMWCSNSCEEVGGESQKGRFAHLVSDFLPNKWLTSPHVWEMLVSHPFPSSQSPTESVEVSVAETSSDISQPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF29</accession>
    <name>F9WF29_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_01000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002095">
        <property type="protein sequence ID" value="CCD15897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01000"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="314"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="661" mass="74555" checksum="5DE27A2605A10CE9" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFF9</accession>
    <name>F9WFF9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002139">
        <property type="protein sequence ID" value="CCD16027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09980"/>
    <dbReference type="OrthoDB" id="1804501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="19085" checksum="B1336E2746420B6D" modified="2011-10-19" version="1">MKSKEEFFKKNGEKRQKERHKLISVVVPAFFSFYFSFLFFSFALSLDISNEKIKENGGRGGPVEQFKFRCGYKYVFTGMFVCCVCVYSLVFVWFCFVFFFFFSSSSPPPYFTIFFRFGFFCILFVFLPSPLSSLSLRVCVCVCVPLSSHQKKQKHLFFVFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL7</accession>
    <name>F9WFL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002160">
        <property type="protein sequence ID" value="CCD16093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14915" checksum="25645AF1E863977D" modified="2011-10-19" version="1">MPYFRGTTPGSWLTQIGRRGMFFCSISVATLLSYLPFCLLLPGLTKPPQYLTTVKAKFFLLMMSHFSLLFPSCPFDFPPPHYHQSAVSLTADAVRLVMWLVISLLRKLTKLFSNHFFIIINPIVHSMNICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG86</accession>
    <name>F9WG86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 476</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002244">
        <property type="protein sequence ID" value="CCD16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12590"/>
    <dbReference type="OMA" id="RFWNWKP"/>
    <dbReference type="OrthoDB" id="1139518at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="25628" checksum="16A47E473A9272F3" modified="2011-10-19" version="1">MLRRGVAVTPFSLVAVQGALRSHSSTFSKDLPGAGGRQPQPPAIQHNEPIMPMDFNPHIEWFEYPKEVFDPKYPYTREESIRMTEESWESTMDEMASRYGMRLNMSTKPTFWMAWSLMFFYSWYTLWGCYRAMGTEPGWTHFRGVVLNQPNVPTLEEDDIYLDQWIRPEIREKHAKYDRFWNWKPLTKRDGAETTWTIPLQYRDESEWRHMTSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE3</accession>
    <name>F9WGE3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01530"/>
    <dbReference type="OrthoDB" id="1683954at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="264" mass="28625" checksum="D1FEE3D9774D81CF" modified="2011-10-19" version="1">MDEFITVFANAKGESDSKYCLGSDKAAKPEDLKDCFGEKNFSEESLVDIGERASGQEPNLFSAIDGIKYSELSSHFTRNSSTTEAGCNLTKGISGRILKSVSLEKSLLWGGGILTARRGFEGQFNSSSFGPGEIGGNKNEVKNATWTGNHASQIVHLKNASDAFKVFKAVHETIQATIEDIEQKIQSCLGGQESGENNTEQNATEPDIPPPTSPTCFDNVAKINDDLKEKRALLARYQKVKGWIPTSSASHPTTQFLCLPLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH9</accession>
    <name>F9WGH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002274">
        <property type="protein sequence ID" value="CCD16415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01590"/>
    <dbReference type="OrthoDB" id="1231780at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="SSF47616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12685" checksum="F553C3F6C123216C" modified="2011-10-19" version="1">MDWAPSTFGADFRDVITNLIRLPEDKRDKAIAQRGIDRMTRSFKIANNALAAQPWFSGSNFGVGDIPLGCYAYAWFEFPIEREPMPHLEDWYSRLTQRPAYRKAVMTPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGR3</accession>
    <name>F9WGR3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 532</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002306">
        <property type="protein sequence ID" value="CCD16500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14190"/>
    <dbReference type="OMA" id="HEFEGAS"/>
    <dbReference type="OrthoDB" id="844245at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389122" evidence="1">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="322" mass="35407" checksum="FA83358E56B47E07" modified="2011-10-19" version="1" fragment="single">MVRNIFNSFSCFLSLFFLRLVGMSYSLEGGGASFVDLDLGELVDSLLSNAGLCSVELCGSISSRRKKSLNAVPSVLLNDICCGRNPFFISLKDVSSSRLVELRAKEVPRRRRRVKECVRDLYKRSYSVLDSSSANNNNGIPIRVLSGGVVRRMCRGVTKAVVLFKNFKVCEGSGRRRGARHGFRKVKYSLPSTYGCEDDRSCSIDHTFWRSVAVVLNQRAVFKALFCEMWHEFEGASCGRGLPHVLRILRSFPLFGVVVEVGVAQWRCSAGRCSAEPVFFVFAMGVIIHETSNFIGVAVLGSGDIACTALADVKTLGDALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH46</accession>
    <name>F9WH46_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 592</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002372">
        <property type="protein sequence ID" value="CCD16635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="24190" checksum="F5C85DF5A5C5BD7A" modified="2011-10-19" version="1" fragment="single">MSNSPSSPSPEGMAQQDNPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPHIHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDVMEGMVWAVCRMPPHYAQCLECILTIMCMDPLYHPGERGLHSHHLKFPPFLTTKRKDGGAFKCLEKKGMFPKGQAQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH75</accession>
    <name>F9WH75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 609</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002391">
        <property type="protein sequence ID" value="CCD16664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15710"/>
    <dbReference type="OMA" id="REVKNDY"/>
    <dbReference type="OrthoDB" id="443240at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="302" mass="34010" checksum="BF1E773BEF1E1A4A" modified="2011-10-19" version="1">MVLYFKSDVKDRLWLLWCGSLRVAERNTRSHMPMNLAPRFGEPLREGILSEQEMLRNVDMAYFVITKDGPFYETYIRGNGRDKSSSIDRCSTRMAERVHSAMQDTTKSDSHHVGARSKEEEVPNELHELLGALKDLEETVQDAFKDIFYNAYSHFLSTPGSSFDVVVPPNVVEIVTAASILDLMKFLKLSEKECLPGVPVPAPQSKPHYALAAAEKESQSGMSSEPPMVFVIPAKFSMPLTVMSRKAEEWIRELFATRSREVKNDYFGDTPEIEVLPSARRVASSTENVSSMGDCTPVRDHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH80</accession>
    <name>F9WH80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 612</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002394">
        <property type="protein sequence ID" value="CCD16669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15760"/>
    <dbReference type="OrthoDB" id="1715014at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18091" checksum="ACC5D83DF1F12E53" modified="2011-10-19" version="1">MGRELGTLQRGWFTVRGSLISHHSQQNHIPITCKNGTPSHNQSLLGECVSFPPNTHFPPFICDTSSPPINLFSSRNFSQTNPKWQSPGNAFLGGNRNFEREGLLKREGLTIPLSHCTTLSSPHPLSSINELLSSNMFPPTQPASMIENSLLHLFPIFRKMNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH96</accession>
    <name>F9WH96_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002399">
        <property type="protein sequence ID" value="CCD16685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="14915" checksum="00856D5EA130698C" modified="2011-10-19" version="1">MMETESMKQLLPALRFLTSAWGRRVGMLRYALEVRFIISSISAYDLLPGLHIIPACLCDLTCRWCAACSLAWYQRMLLAVSVIGAYLCARVCVCSFEEGVEFRVIILSEMEICGESGLCGSVAGGFYNAIGGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB1</accession>
    <name>F9WHB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 624</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002408">
        <property type="protein sequence ID" value="CCD16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16070"/>
    <dbReference type="OrthoDB" id="1719809at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16896" checksum="79F4D5A535374E8C" modified="2011-10-19" version="1">MMTGFTPSPPTHRSPCSPGYSLIANPSPRIALQKKKDVLEKSVLFWKKQAHLMRGGLRTHELEKLFVFFGCIRTRTGTPEPAPAHTLGCNARCVSGDFVEVHTVFPEIPSEPSLLVSVYCSRINPTTSTEFFCAASHVYVSNSSKHWSTGPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHF2</accession>
    <name>F9WHF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 244</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 636</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06430</name>
        <name evidence="4" type="ORF">TCIL3000_0_16480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001955">
        <property type="protein sequence ID" value="CCD15562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002422">
        <property type="protein sequence ID" value="CCD16745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16480"/>
    <dbReference type="OrthoDB" id="1631954at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="2">
        <location>
            <begin position="73"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="21926" checksum="A06EC676E6C342A9" modified="2011-10-19" version="1">MYKLPGNSHPMYSESEEASGSVVESGSELEDHHTLSPAQRRTVRGNGGARSDSFEESSGTPRELGARSPEEVYVMDTSFIVELETLSDLVRCAERCLVVVPLKVKDELYGLKEGVSNAGGMLRLLEKGSHPSTYSGIRLQKPREASKRIMSVQRNNDDHILACACYFKEKGYKIKLLTGDGVLKLKAHAEGLQAKDKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHL0</accession>
    <name>F9WHL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 664</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002452">
        <property type="protein sequence ID" value="CCD16803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17030"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18001" checksum="6167D158B06B6B6E" modified="2011-10-19" version="1">MRHISWRVLSPKEAGGRKARAPRRVGAPSQIPPYMRSNTAHDSFEKHAHVSSEIHTLPPTDTHGGDVPLASFTPAVAAHNACQPAFPKTSARVSRVRSSAAGFSPNTITGWQALTSRECGRHCPEACSSSNTSPAISQSPRRSARRHGGSTHGSLASEFAFNQLNSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN2</accession>
    <name>F9WHN2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002464">
        <property type="protein sequence ID" value="CCD16826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01850"/>
    <dbReference type="OrthoDB" id="1698694at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="24786" checksum="FEE08C27C7444DD2" modified="2011-10-19" version="1">MVFANAKGNESGTHKYSLGNEKAATPGELKDCFSGKDFREESLVDISEKVSEQEPNLYSKIEGIKHQSLKDSFNGGSSAGCNLIKGKTGGILGKTDLQKSLWWGGGVLSIGSAFDGSTNSIDPGEIASATAKKKRAFWTADPAKQIVHLKNASDAFKAFKAVQETIQAKVKSIEDKIQACMGGQESGENTTGQNATEQKTNSLTCFDNVARITANLMEKRALLARYQKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHQ7</accession>
    <name>F9WHQ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002475">
        <property type="protein sequence ID" value="CCD16851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01930"/>
    <dbReference type="OMA" id="FHCDEVV"/>
    <dbReference type="OrthoDB" id="1174497at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="Met-dep_prot_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="PTHR11215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="UPF0160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="388" mass="42902" checksum="A868A0AA0932855D" modified="2011-10-19" version="1">MSRGHLKEYVLKHLTGVSVLPSFTDAGSGVFPVIGTHNGSFHCDEALACGMLRCSAEFSTANILRTRDASLLEKCNIVVDVGGEYNAETLRFDHHQPSFQTTMTTSKSVYRTRLSSAGLVYKHYGREIIQRYVEAALSSSYRSELITMTSWDLKRKNLTDSELDTIFDIVYKNFVEHIDGIDNGVNSYGPAAQVDVADAGSLCVRNYVVKTALSDRVGQLMPWWNENDSGNIESENAAFLQAVELTLLEFITAVHFYVFTWLPARGLVESAFLGAEKVHPSGRIIVLKERYCPWKDHLLEIETERGKEGHVLYVLFADKSGWRVQAVPKDAVGFESRKALPWRGLRDAELSEASGVDGGVFVHVSGFIGGNKTYEGALAMATKALTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHY9</accession>
    <name>F9WHY9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_18160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002501">
        <property type="protein sequence ID" value="CCD16934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18160"/>
    <dbReference type="OrthoDB" id="1693496at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390410" evidence="5">
        <location>
            <begin position="29"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="20"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="27204" checksum="C75937AC9A208D8E" modified="2011-10-19" version="1" fragment="single">MPPKQNQARCWYLVAMEVLLMLLREVRAGPKDVAPEFNVMCKIYSLAVNGEAIPAADWNKVVADEILEIKRLNMSTSDETFFNSIDEKPGNTDAEASERKALKEFVGKSREGDRGSDYVRPPPSDSRERANRRIGLLLLQAENYKRQLEAIPEPSVEDIRDKLLGVVFGLGHKAVSKANGGSGTFQSGLAAGCGGSGGNAGVGKSLASDMVCLCTHKNSAARFGSECYGSDGAASKHYDSETNAGDAWAEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI10</accession>
    <name>F9WI10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002510">
        <property type="protein sequence ID" value="CCD16955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15338" checksum="7E0ED3AE2C26C6DC" modified="2011-10-19" version="1">MYTALRAPTISNYRPRKVTTQNVAKQALVIKPKNPHRNRTDHVKVNCVKSPTKVSQNQHCEVMLRVWLSTNSASHWELNIENTHLDHAQYYLLGASSALSSHVCSRTYICGCESPIPAKTAVESLYLLPYTKIMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI46</accession>
    <name>F9WI46_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_18600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002527">
        <property type="protein sequence ID" value="CCD16991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18600"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="151"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="493" mass="54338" checksum="0CA68E1239F4F133" modified="2011-10-19" version="1">MVDQHSSKKEGEWLCCFLIFISTFSVKIRIFMLFFSEGKLAYSKTSQRKLKRFNREAVIMVCFVNVILVAAMICNFVTDATAQGAQVQNNDNSEQFALLCRIYNVAKNPPINHVDLQDPLKIVKEIDALNSSLAEEKLFNETEQVGNSSDAYVKLTTTREAAVAQAILSRITQKAHTILKEIIKVNATRDIERAKANFTQVIFGEGMNESHLCDGVLNEISDRAAACGNKGLSSRGASAGKNLVVDFFCLCAQRPDGNGIDNVCGVQVGGKSKGNYHGWSDTAPLGSPSMWASIKKECGKLLHKHPKSTQEGYELLEDFLTHLKSGGLYRWGAADNNGVDGSDRKPGMLGTAAETKESNQEKGLVCDGSRGNKSPQHARARRKSGTLLPGGVCVYYGSQSEWQSIPWLMKLTTALATVEHVNNKTASIQRGIEKLHTLLQHAEEIYETTNVISKIQTPVVPTNLQKAAKRLTAFNAAWSQQYHFILPWVLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI79</accession>
    <name>F9WI79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 742</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_18860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002539">
        <property type="protein sequence ID" value="CCD17024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18860"/>
    <dbReference type="OMA" id="HYIDIPF"/>
    <dbReference type="OrthoDB" id="1114699at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="PTHR33146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395072" evidence="7">
        <location>
            <begin position="24"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="35262" checksum="D01473334F9ECFE8" modified="2011-10-19" version="1">MMRFVSPLCPLILIVASLLPLHASGWWGFGHMVVAEIARRNLDEKIMRTLENYTQHLSMSGPFPEIPDFVQSACWPDDLKGYNLRVMNGWHFTDNIYIRGNFTPENITKQKSNVVSVIDSLSNTLKRTDTPIYVRSFALAHLVHYYGDIHQPLHTTSMMSNDFPHGDLGGNLIRVSFRGHHMNLHALWDSICQGEQKQLKRPLSPESYAKVISFADRLVATYNFSREEKELTSPAAISKEGYALAKAVAYKNVEDNTILNESYIENCVKTAEERVTLAGYRLATQLTKIFKRKRKSSKGHRDDSIYASPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI82</accession>
    <name>F9WI82_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_18890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002541">
        <property type="protein sequence ID" value="CCD17027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18890"/>
    <dbReference type="OrthoDB" id="1668612at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390377" evidence="8">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="43"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD17027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="43778" checksum="5CF86D5A08C8A8A9" modified="2011-10-19" version="1">MIHRNVLVFFLYLAVLLSVCHATANGENKEETKSFLTLSKARSICNASRTMKGVHSYVSRKITEYQKKYDEMDMIRDVARLKVLMKVNLDAKCGREATFLLYVQEGMITFREALEKLRAAGVRAVASAGIAAGRLDEFMSVFKQAHGKNNDPRNCAGKIGSVVDGMKLMLKECYRGATIEDGFHSVADVEAEFGVKDLELEDALAKHLTPNDKDLSASSDPTVCNLGIIKNNGSYVKDDKSKGDIKWGDGVLGVKKDTNNPDEWNKSPTTTIPVIKSAISDFSDFKKAVADVERCYAGLRDDWTDSRLKEADMQRILASLKYNKFNTSEAVSFHVLSSLQTDENNTNVLFPEWNREKVAGKILEEELALCDGKNGVRKFSAHWCGIWGFVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIA9</accession>
    <name>F9WIA9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 759</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002558">
        <property type="protein sequence ID" value="CCD17055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19120"/>
    <dbReference type="OrthoDB" id="1718266at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18880" checksum="B2AA7D551504338F" modified="2011-10-19" version="1">MHKIQFDRHAKLMEKLSEETKQKGILTAQEADRLKSTADEAQKKNDEVHGKAHEVMKNHTVHHERTKNATKKALGETLIEGNCRTTASLLHVLQCHVKGEQWKTNVNIETARSGKNYPKHLKGHFGKNIDNCKGIGRKKILQWYRRSAQGSIGKVDKNREKGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIJ2</accession>
    <name>F9WIJ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 801</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002604">
        <property type="protein sequence ID" value="CCD17140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19870"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="420"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="664" mass="75612" checksum="B15328A827507CA5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT8</accession>
    <name>F9WIT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 832</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002638">
        <property type="protein sequence ID" value="CCD17236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20720"/>
    <dbReference type="OMA" id="CDANEES"/>
    <dbReference type="OrthoDB" id="1201126at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="241" mass="27330" checksum="101ECE8978694A94" modified="2011-10-19" version="1">MRSRRIKRGCTIMREYCHRSAPLKNTPEFRAIGLVHKIFVQRGYGFALMIPPPVSLLQSRNRCDANEESDSTEGLGDKKHPVSLSEECVSVWFPFLPCEAKHEGVGDDRAMPLGGCRVSPGNYVKFTAVGYYNQDTADYIWRARDVAPCDPREELRVALERVRNSRWDEITLEDVQKAKCRAVGRCSAPPGNLLGRIKHGTMREASDSSSPNGGDTFGQYIVRESDLRRPLSWMRDEMKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW1</accession>
    <name>F9WIW1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_20930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002647">
        <property type="protein sequence ID" value="CCD17260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20930"/>
    <dbReference type="OrthoDB" id="1672901at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390405" evidence="5">
        <location>
            <begin position="17"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="37959" checksum="D4456CAABC5B05B2" modified="2011-10-19" version="1">MKFWTVVMVFVGVVGAENSDTSGKNDHNKDEHSRLCAVLKVAVNKWGEVHTREPTDPLRKALGRTIFGDEKGGDLGSLKGELPGGYKDVGGRRGTLCGQPREEDGYTTVHQPRWPGHSAPHDMVCLCTVGPGGWPLNVSENTLCGGDKETLRAGSGKGWGTVGIPSHHVEGKEQIQATWTNVTSECLQGGKEKGEELKDALNKFINTLVAKPSHAHPSRRQLGEGNPGEFYACTGSKTYGVCVMYYPNDKDTKTWWKDLQTAIKEDEEIQKQREEEEKRKQQEKVNDKDQPRAERLSATPTTTNQTEASKQDNLTDKLRRLNITSGTPISMPSSWLLRAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIX0</accession>
    <name>F9WIX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 841</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002649">
        <property type="protein sequence ID" value="CCD17269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21020"/>
    <dbReference type="OrthoDB" id="1205219at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="767" mass="87128" checksum="B3647AC4438275C9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJE0</accession>
    <name>F9WJE0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002713">
        <property type="protein sequence ID" value="CCD17444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22630"/>
    <dbReference type="OMA" id="PVAMAGQ"/>
    <dbReference type="OrthoDB" id="923636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="461"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="634" mass="68580" checksum="16E5C719D1E491A4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG6</accession>
    <name>F9WJG6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002723">
        <property type="protein sequence ID" value="CCD17471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22890"/>
    <dbReference type="OrthoDB" id="1612139at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1059" mass="115612" checksum="B41583755F02C79B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG7</accession>
    <name>F9WJG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TCIL3000_0_22900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002724">
        <property type="protein sequence ID" value="CCD17472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22900"/>
    <dbReference type="OrthoDB" id="1710124at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21234" checksum="91E21EA42A0F9AEA" modified="2011-10-19" version="1">MSWYTITSPRTIPWSMERDVVDVLLDGVTSADRINLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEANVCDAIWQYLPYLLWKFRQSATPLVKHFGPTQTWKKWHWDSWKIYFDNDDMPLEAIDQEIWRRCRRPPPVPPYQPCQGVVLVGVTPALIQVPYSTVGYLVHLPVTPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH7</accession>
    <name>F9WJH7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 913</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">TCIL3000_0_23000</name>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002728">
        <property type="protein sequence ID" value="CCD17482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23000"/>
    <dbReference type="OMA" id="LERQTIC"/>
    <dbReference type="OrthoDB" id="1490656at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="662" mass="72755" checksum="F00245EA892ADF81" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP3</accession>
    <name>F9WJP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 934</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002751">
        <property type="protein sequence ID" value="CCD17550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23640"/>
    <dbReference type="OMA" id="DFPMVPT"/>
    <dbReference type="OrthoDB" id="1276110at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040048">
        <property type="entry name" value="ZNF277"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13267">
        <property type="entry name" value="PTHR13267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="320" mass="35856" checksum="ECBFA22025ACA398" modified="2011-10-19" version="1">MLDIERLRASCREVLERHQDLRPLDLPCAICHQTFCEQNNAMEHYRIVHGISTTHFDDVADLSGFFSQLRSLLFPADEKTLHCPVCGARCGDESGFHAHVQQSGHSHWNSECISTLSPFCVFPVCVREEGGDEAFTGDKGEVDEISDEALEVESSENGWEEEEEPVLCLFCDVASLDCLSHMRETHSFDFITAIRNRKDVRDVYDVIRVVNIIRWCVTNNTCPYHYKDSERDPEACKDEIGSSSLLSHLKAHPEHAIPRTVPNGDSELIPRIIGDTFISSIVMGNEVELVGDGGTGGEQDYPMVPTIVEIAKKHANEVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3K2</accession>
    <name>F9W3K2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1067</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000427">
        <property type="protein sequence ID" value="CCD11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26740"/>
    <dbReference type="OrthoDB" id="1762881at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="21299" checksum="462DCCE545607758" modified="2011-10-19" version="1">MSCLNVSLASFRDSAVTSSAAAVHAFAARIPQLHDADVFAPVITSSSTRRCSSLDAVRFPTKPETPAYASCALSAAAVTSASTACARSASSFALAFFPAAATTRFTVSVLRAFTAAATVAQCVAWPSSFFTEFKSPRNCSASPQNAFTCFNVSFFTSKAAISASAADSFTIFSAASALARDLDATSAAPSSSLRLSENFLNRSFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L4</accession>
    <name>F9W3L4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000433">
        <property type="protein sequence ID" value="CCD11735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26880"/>
    <dbReference type="OrthoDB" id="1690977at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="254" mass="26469" checksum="C80ED8FA0751AD4A" modified="2011-10-19" version="1">MSLCSCAVADTESVWRQCILHSSDEELAAHWTVFSEGVGATAAAECADDESRGRAALHSEWCEGWMSLCSCAVTDTESVWRQCILRSSDEELAAHWAVFSEGVGATAAAECADDESRGRAALHSEWCEGWMSLCSCAVTDTESVWRQCILHSSDEELAAHWTVFSEGVGVTAAAEMVCGIGGRGTAFVEGFRDGDGVTSLTAAXMAGGIGGRGTAFTEGFRDGDGVPSLTAAEMAGGIGGRGTAFPKGSVMVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M2</accession>
    <name>F9W3M2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000437">
        <property type="protein sequence ID" value="CCD11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02920"/>
    <dbReference type="OrthoDB" id="1695959at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22729" checksum="82E01BECA9F291D9" modified="2011-10-19" version="1">MDKKLENGVRQALFGNIDKKGLSSMAQDPPGDEKPTQPMHRGSGRHVGDTNYYPGWSIPHDLLCRCTPGSYSEPFYRWWWNARLHDEAAEFPFFGRKWEDMVPDPCHGWYFDEGYQQAKGLHSSWEAVVLGCENTRSKPRGTEGHNLKEKLKKLNIAMQQFITLPEQSGGRPKLVGLEMHHTESDGEDEKRMHVRYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3W0</accession>
    <name>F9W3W0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000483">
        <property type="protein sequence ID" value="CCD11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27780"/>
    <dbReference type="OrthoDB" id="1732662at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17508" checksum="AC088AD26A5E1889" modified="2011-10-19" version="1">MSYSIQTRFFFFYLFHGITFIDRNYIYIYIFFSLVNSIFVLLHFPFLYGSGCILSFAVGMPHPTCLLVCGVCQLVFSCGTTCFPPHLMVHFFPQFALTPRVGIILRGWTVPKQNKNGIEWGERRQDTEGRRKEKENGEEGGGKVKASLKGKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y2</accession>
    <name>F9W3Y2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000492">
        <property type="protein sequence ID" value="CCD11860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28000"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19315" checksum="2ECC6ADB9F873758" modified="2011-10-19" version="1">MQVTSAVRQRENREKVTAVFMDYARAFDSVDHGCVIEVRKSLGVEVHFVPRIARLLQGRKAQVRVSSIKSEDIEMMCGVPQSSVLGPLLLLNAVVDSLSKRLDEIQGLMHGFFGDDLTIICMHAKLCWRFKKRRRRAWIASPVGQRSSLWRPQRRGRCTRCFDPATKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W420</accession>
    <name>F9W420_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000504">
        <property type="protein sequence ID" value="CCD11903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28410"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="18872" checksum="E651D599A533E87A" modified="2011-10-19" version="1">MINTGGTSKSDRESHLRIATEDAHKMKQAGVIGHASDLPTKGWAIPSSVVEEKTAGRRRGFIAWPKVKNAKNDYEAEVPLGHISRYLSAVCNEAVALFDLEASFLQADMPRDIRAGFRCRTENGELVELKWLPVVYKGNTEIVHTITRALAGGCGGSHNGVRGSKPLENPHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W421</accession>
    <name>F9W421_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000505">
        <property type="protein sequence ID" value="CCD11904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03000"/>
    <dbReference type="OMA" id="MNSAGVH"/>
    <dbReference type="OrthoDB" id="986860at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="282" mass="32839" checksum="C7920CCB51622405" modified="2011-10-19" version="1">MSESRSDVPSAGVSGGRREVLSDIKRRREKLELYQSSSHKMKSLMMNSAGVHSGLGNNELPSNPIWMKFPTKCVKSVGSVDEMREKLKYFSHSDDVMVVRYHQENCTACNALDKAFEFLCHQSADRLPNLKFYEISKSSTPELTKNLVRYPQVKGYSGGHWTDLEFKPPTEFREELYAGVEREVVRRKREGRPVTALEAEEMYFSAAGPAMTQVLEESITKFYCKAQARLHNYWKQVSVRRAWFFRRFIEPKIDEQIREEWRLKSIFGEKLLYGPEPRVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W445</accession>
    <name>F9W445_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="103" mass="11610" checksum="CBCAE7E9A6F95D7B" modified="2011-10-19" version="1">MIFIAHQLIEPTNLYCGKGFPHSFPQANTEATVTNGYHHGGLLPIKIFFHIFMLQRVPLVKMKCAVFVPWGSFFKFGMGRFFSSANRGPGGGTEKLKFSQRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W490</accession>
    <name>F9W490_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_29040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000532">
        <property type="protein sequence ID" value="CCD11978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29040"/>
    <dbReference type="OMA" id="IDWFESK"/>
    <dbReference type="OrthoDB" id="330091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="277" mass="31407" checksum="F943E90B4A04EDF9" modified="2011-10-19" version="1" fragment="single">MAEMSNNRTKIKEMPPSGGGEFFCKYYLPNVKTMIGKGASAVVYKCTSRVTNEALAVKIIDKRLLPPSDIKNVNMEVEMMRRVGDHPHVVRLIDYYEWKTNMFVVMDLLDGGMLHDRIRSLDHYSERSASELIGNVLSGLAHIHAKGVIHRDLKAENLLLRKRSDKRDDPWLTDVCISDFGLATTGPAFSCCGTAPYIAPEVIELGYFHRSREPYDAKCDVWSLGVITYILLSGKWPFSGSCHDAIFKRIVKGKWRFSGDIWNKISAEARDFVRKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4B8</accession>
    <name>F9W4B8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000539">
        <property type="protein sequence ID" value="CCD12007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03020"/>
    <dbReference type="OrthoDB" id="1559868at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="436" mass="47079" checksum="DC1BFCE93114E091" modified="2011-10-19" version="1">MIAQRRIMAPSYTVTQMRGTGPHPLQLRLAYEGTCCPYDLPGERGRSVCGPKCPLWMKSAISGGNAPSGCSDGTDKSKSKSEGPLEVATGKKNMELAVPTHDVDTCNETIVAVCAKPAAPLPVLAAVEVMPPQPSTWGIVMTKAELDVEKNSTGTQTEEVLDAGGKESSSAKHLPAQPKASQGAGVSPALSRATRDVAVGCDDAVSESAGRQENDARMRPGICAEPPMMVGRNQIEHLLSDTVELVYKKLQGAALKVVALDDLKHQLTENFDHLKEKKCVDDKIELSMHLYALRRQVENLRKEWDVYKESLEAAVGMKDQMFLDRPERTVRVEIIRGYEEEPVPYKKAPFRPLVVQEARKRSETSSFSSDSTSSASKSSTTKFSSSYITYTSQSSSQSSALSSTLSSSSLSTDHSSSLSTSRTSSSFRSSSSTLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4F1</accession>
    <name>F9W4F1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_29620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000547">
        <property type="protein sequence ID" value="CCD12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29620"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388650" evidence="4">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="40"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29260" checksum="10F399B6AC483152" modified="2011-10-19" version="1">MKVLSWLMVSSLVLGVLSMGMVSLGSGYNKNAFSTLCAVLKSTERLLNTNTISEPLKSEMEYALYGRPGGVLTVENGKVSVKANRDSPINRSELCTYYNGGYGCFAESLAGTLLCTCTPGEGGKDFCGLGTLQNADPLSGGSTPLERKQDLFQSLWDQVRNKCPYGKGTKQGTHGDDVGHLEKAVQRVRDTLKQALPFFYLGGRPGRKVPCSGSDPRNVCAAYYTCGWPRKHVHIPWLDTIQQALEDLKAVSQTVSVPSTPTDGRDPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J0</accession>
    <name>F9W4J0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_30030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000560">
        <property type="protein sequence ID" value="CCD12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30030"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389872" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="840"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="884"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1273" mass="139399" checksum="8BF1DB703F192F2A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R6</accession>
    <name>F9W4R6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 121</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_03140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000594">
        <property type="protein sequence ID" value="CCD12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03140"/>
    <dbReference type="OMA" id="EMNPHPL"/>
    <dbReference type="OrthoDB" id="1286165at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389804" evidence="2">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22653" checksum="FF9C14EC8247E620" modified="2011-10-19" version="1">MTFIAAIAMILATTAVGSLAQTDSQPLLFVSKTVSDEYVVVGDSVEFTVTVYNFGRGPATNVTITDLLSDGSVRKKHVDVLSYGESVGLKYSVTPKALGSYPVAVTEVLYDTGKEGERNGKAYSNILREGTAHFYGETYDDESFRGVVSVVTRERYDRLYRRYIRESAVYAFLCLIPILLPLIVYRMEQNQVDLLIRRSKSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W540</accession>
    <name>F9W540_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31840"/>
    <dbReference type="OrthoDB" id="1657799at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="616" mass="70424" checksum="7D8473D8C5D53209" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W588</accession>
    <name>F9W588_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1294</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_32280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000679">
        <property type="protein sequence ID" value="CCD12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32280"/>
    <dbReference type="OMA" id="VGRHTET"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="506" mass="57448" checksum="E83301E200ACAFB9" modified="2011-10-19" version="1">MVSARRQAGVVHLVKIHGLERDCALAMTKKARRAALTYKNGYACHVCGDAFERRGLLVEHMAQHPPDVAPTVEERPKGAREEDEADDGNAFQCRWCAKRYTVYAWLRKHMIQNHPEKQLKSDDIPVEQEASSDSDGEPVQEEQIFVCQKCNRVLKSKTWLTRHKCNVTSNINSEDSNVAEQSDTAECPICSKEYHYKWLLRHMREKHPGHDESLRPQPRAKPKRKTMRSEAKAQDEGSRSTELAGDGDGEGERPRKRPRMGRHKEGEEGRDYVCGRCDSAYKQWYSLVWHTRTHHDHATTVKRKVKDGTVAVTPLLQRSLQCPYCPMKCALKQYLTMHLQAKHGQRKKESEHNLLKAECEESAAHLLECPSLRELRKKHGLETRKDGEVFFSAQLASFLKELFKLESPLSPPLDSPKLTPARAVKRHRSPTALDTAHPPSAATKLIGVCPARAMRKRVREADSLDKAFYFNVPLGEARRGSRIRLTSPAGIQSHRGSRESSAARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H0</accession>
    <name>F9W5H0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33020"/>
    <dbReference type="OrthoDB" id="1701524at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20726" checksum="17972DC7266C6260" modified="2011-10-19" version="1">MDVTRCTLRCLVSWAVIASSSEKSPLRHSTARRRPTCVMLIRAGLGVCVGQWVGLVLTTENWETLSCRHSVLSCMCGRSITIQNNWRGSNTGDAWKQSTGTGSHARLPSLVYTDSTCAVGCGTPHCILLSSVTVPGMRKVATFPQAVWWEGHEPSMGCHAMGAYQQRDGYAAVEATRWMAFCVRSQWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H6</accession>
    <name>F9W5H6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000714">
        <property type="protein sequence ID" value="CCD12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33080"/>
    <dbReference type="OMA" id="MYVESGV"/>
    <dbReference type="OrthoDB" id="676164at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="477" mass="53477" checksum="8BF8C353EE6101E0" modified="2011-10-19" version="1">MKVVVWGSKRELSFSRSFCRTLGYSGFFLLEACCVSVGCMWPKVFAPLLAFRHAPANKFPQLKLRLRQERSLTHKREISIPLSSFDPKSIDFAHREIPQGSVVEIRDADHHRLLALGFYEPSLLRVDVFHFSPKVVTDLPVISEEFFLDRMKGAWERRQRVFRHSENGSTNAYRIVNGYADGIPSLYVDLFSSGFARVVATSTGAERIVPAVCELLRQRGVEEVLLDTPFLKGCEKVTFITPTITLPQLYVESGASNLWLPRDVHPGTSTNRWLLNTAHRRSRLLLRELCHGKRVLCVNDRSGAAALQAAMVAKQVLVSETDGPLLDRVRENLVSNHGMAIFSTCETTNAGVDHVNPRRHDVVYLEHRSDDLSTQQQWGSMLRTLLRRGICGNGSVLIAAQEVATLGIHDYAIPQSKNVGCSVPANREDIVNTFSGVAGEHGLSLRLLRFFGPSIDHPIMSYMDPACFSYVFLLQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5K3</accession>
    <name>F9W5K3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000725">
        <property type="protein sequence ID" value="CCD12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33340"/>
    <dbReference type="OrthoDB" id="298504at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="27999" checksum="D2AB5AC86EFFE7F8" modified="2011-10-19" version="1">MPFQLRDCGGGGELGFWMPGVGLDSSFYATKLLDASDALSGMLGVPESIKHAQNEPQRIVHSLRHKVRMHALRRFAFINASKVWESSMSIRALPFLNALRRSLLTVPQITVLRFRDARQMPKKFDAVNEPSTVLKRFAPLHLAALASPPVFYGECGTVQDLEALQTDEQKTAVKSLRCCFSPNMVPGSSAVYELLLTDSLIASLVAVLTSQLQASCGSFVDIVTLTHDNRIVTHCSSPEQLLHKRRFCDTVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5N1</accession>
    <name>F9W5N1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000740">
        <property type="protein sequence ID" value="CCD12483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16333" checksum="1851020C6309EB4C" modified="2011-10-19" version="1">MNTVHNPLNKNICGHWCRSAFPIPRDAVATIIVVHYPRYLIIFLSRSKGSMPFASWTSAWECAFCPHNNSTARLNVHPMLKEVNHHTEQGMICSTSLVETRVDCVTSVSDLTNNKKNKKRARNMTPPLGVFPGKIMPSKTHSFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W641</accession>
    <name>F9W641_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000820">
        <property type="protein sequence ID" value="CCD12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16421" checksum="85DB8BEF8B96E30C" modified="2011-10-19" version="1">MVRGSHISLAGPKLTHIIEHSDCLTKAFPFTTLQIFNGSHTHTHGHRDATRAPMDAATRSHAFASRRHHQLPTHHMPQPPEKFIGAHQPHECHNVALYAQSGATLLISNGAPRAQIPHFHFPLPDKANSPRTNTARHGHEEKQWKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W642</accession>
    <name>F9W642_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000821">
        <property type="protein sequence ID" value="CCD12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35060"/>
    <dbReference type="OMA" id="PKQNAPC"/>
    <dbReference type="OrthoDB" id="1654920at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009836">
        <property type="entry name" value="GRDP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34365">
        <property type="entry name" value="PTHR34365"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="840" mass="87661" checksum="C88B225CB630E77D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6C8</accession>
    <name>F9W6C8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000849">
        <property type="protein sequence ID" value="CCD12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35900"/>
    <dbReference type="OMA" id="SINCCTT"/>
    <dbReference type="OrthoDB" id="1671554at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40391" checksum="6D1CE3E7414F9825" modified="2011-10-19" version="1">MEGRGVRRTRDEMEEETVAPIVQAEATARDEATAATLAAVRPVAVRREVVAVPTGRWTLDSSVEDVLMERYGGLDGMRLHDFLMEHFGETFGCPSVSMRVFIGNPSIFLRDESLCTLVTDSEPYREYKTMREGVDRLSAREIFSLLQWEGVVAANEVEDINACVRGKLNAALLSAKRNEETIRVGNAPSGEELSGAYDSVFNARWSYVVKSDEYDTKWLGMGVVRVSEGEQPHLWCEKQADAPYDPEEPWEGDVVPGVEGKLVMATLESHKGWPYTLFNAKTSKIVSADVLRKYKDVHNAHLHIRRENLRVWNIVKKGLDQWLNGVKEVHPFTVIGTPGIGKSFAPAPCCSINCCTTRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E7</accession>
    <name>F9W6E7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_36060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000854">
        <property type="protein sequence ID" value="CCD12752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36060"/>
    <dbReference type="OrthoDB" id="1667563at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394721" evidence="5">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="80"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="402" mass="43912" checksum="FC61E550A1693935" modified="2011-10-19" version="1">MMKLFMVMMVVMGGWVGEWGVMANGEVSVVQGDNVKPFELLCKIYNVAQNPPIKPVDIKEYQKIVDDINALRAAANGKEGVNTQTEASRSAQTQLIGISQEAHKLLDEIKKANPEGEAEKARNTFNKVIFGKNGEYGGLCHGALKGVEEKRITACGEPSESKKGTSAGKNLILDFFCLCAQHNLPDEGIDNVCGVSVGSGDGAGWGTKLQLADIMCGEVKKGCERFAKQGVTSTQDGYSLYHKFLAKVKAGGKVKVNNSESFQKPGMLGTAVSATVNSNFHCNGKKTVSTSRTNFGSGSGVCIFYGNQNWKENIDWLEKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKAESQLEEENTDDSPLAQHPNPDENENTDTATQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P2</accession>
    <name>F9W6P2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000901">
        <property type="protein sequence ID" value="CCD12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36900"/>
    <dbReference type="OrthoDB" id="184018at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PTHR11871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="37656" checksum="96AC15260A9EB631" modified="2011-10-19" version="1" fragment="single">MIVGEGSGSSSPSPCFTSDSRTEVLSYRSSRAASEAPHRSCSSLYVAEKTQRRSKVMDEREMCAGKCLDGWEPNTAQFGNGNRVTLEKRTPSSVGGAKTRRGGRGGRSAKAKLGNHAFTGHSANLRPYAAAWDSRLKSPEWFLNNIENECNTCKLPTTSATGPFCLSQKVYYPFGQQEVGYRPDGFQHDDEAVECAEYEATAEMMAATKEIGDMRSVVRQANDSIPSRISTMAISILPDPVPCSSALAIAVGDVNGRVNYCELPCGSVRVSHSCSQTVRNTTSALSAASHNAADLRASSASTSLASTSPSLDLGGVGFQRSLLRRHTHQAYVREMDCLTSVSISQTVKCLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W737</accession>
    <name>F9W737_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1559</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000973">
        <property type="protein sequence ID" value="CCD12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38140"/>
    <dbReference type="OMA" id="CEDYKSV"/>
    <dbReference type="OrthoDB" id="1655473at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="699" mass="79018" checksum="888087C9A76CB302" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7F6</accession>
    <name>F9W7F6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1602</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001022">
        <property type="protein sequence ID" value="CCD13122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="146985at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="21136" checksum="1DDC52B4AC4F25EC" modified="2011-10-19" version="1" fragment="single">MASHGLLHSITLSKFFAEGFALAEPMPEQRADATHPSSVNVDRSKSKEGASVVALTEPSAANSSCRCPDDSTASGNNEQQLLTGDTPGCTSTTALSEHSGFSPDVCAAEAAPTAGEQCADGATGPQTPNEHGAATANGQVGEQRREIELVTLLRAAMARCYELEDGLRRQLRQAQEEKEGGPRHRRKYQERKPAVGAMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K5</accession>
    <name>F9W7K5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1624</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001047">
        <property type="protein sequence ID" value="CCD13173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39470"/>
    <dbReference type="OMA" id="ADEGCAT"/>
    <dbReference type="OrthoDB" id="319085at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="1">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20559" checksum="CF46EC23B1A21430" modified="2011-10-19" version="1">MLRETFQKASRQAPCIVFFDEVDVIGGRRAMNSRDGDQTRLLSTLLTEMDGFSSVSGVCFVGATNAPHLLDDALLRPGRFDYLVYVPLPSLGDRRKILSLTLANTAADVDRLAHATEGFSGADLSALTSGVLLEILDGADEGCATDRLNDREALTQLLLERGKVFPRVVYDVGALERFSRDHALSTRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q9</accession>
    <name>F9W7Q9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1642</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001067">
        <property type="protein sequence ID" value="CCD13231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40000"/>
    <dbReference type="OrthoDB" id="1704148at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="26626" checksum="8B47907AB32DECD6" modified="2011-10-19" version="1">MPWIRRRPCTNFSSRSWASCIRWTDRWATIEAPTRSIRRLGESFSGRRVRARGIFRLWRSSMWRGPCSNRRTRRKKRGSFSVVSCMKPVTWTMSTIITKARKRFSRLWKKFFRRPPRGDGSWENLFPSIPMGRPHTSHRSRTQRSQQSPTHKPHHGGQLYGSPFRVPPEHTKHSSMFMASRCRYFDLIKLSEKHSHLSHKSYSPHTVFLFSPIPFSLSPESRNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W6</accession>
    <name>F9W7W6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001092">
        <property type="protein sequence ID" value="CCD13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40560"/>
    <dbReference type="OrthoDB" id="1717464at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18111" checksum="04FC056170443CB9" modified="2011-10-19" version="1">MTGARRKGRNAEACGACTSQRLNAHWAERISKKSRRPTQNRPMKRLAESRWQLWMDESMRLGAFSGAGAMFLNGHDNRIRGRSDAYRTACSYRAESVAMEMGLDAAYGPAGRFSESGGHCASMFSHRVVERNELVNKVRVHENEFTHAYGAWITDAVTGALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7X4</accession>
    <name>F9W7X4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1671</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001098">
        <property type="protein sequence ID" value="CCD13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40640"/>
    <dbReference type="OMA" id="RFIAPEC"/>
    <dbReference type="OrthoDB" id="646106at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38079" checksum="189B5044F20DE0A0" modified="2011-10-19" version="1" fragment="single">MEEGETDNVVMQKQPPCTRVTLVDGLGQNNRNDVDVCVISGAPHANDEARLESANIIPYEGDVGKTIISSTRRKYAILPSASQNLLNITNLRAIERYIELNKRHRFVDRDKPPADVIPDAPFQRLHGGDEVLQMAVKTVHPRENALDMPLRFIAPECFRIPPLEDPPSNFPLARRVMALLKGAESVQPHWVERRPEAHGKTGGRDVVCVRVLKDAEFRRRTAMRSGDLLGTAIQFCTTASLHYNSGNMELARAFFGKALAAFEASGDVRGVAFCHNLLGICHYRLHQFKVALLHHKQQESLGGCYARAVAQINMAICYAALSEFDFADAALEDALANARACENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W803</accession>
    <name>F9W803_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1685</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001114">
        <property type="protein sequence ID" value="CCD13327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C14.043"/>
    <dbReference type="OrthoDB" id="821819at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394757" evidence="1">
        <location>
            <begin position="19"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17115" checksum="6CA9B3BC1FA58339" modified="2011-10-19" version="1" fragment="single">MDLAVGLLLGQLASSALPYLVESIGKVKRPKRVDVKKAMSEAHTCRPVVPYHAPRPYTEGRVKALFIGINYTGRKGQLSGCINDVKQMLNTLQQIQFPISSCCILVADLRFPNYAAMPIRANIIKHLARLVYDPRPVDLGSFHLLMVLDLETTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W889</accession>
    <name>F9W889_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1718</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41700"/>
    <dbReference type="OrthoDB" id="1669965at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394604" evidence="5">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39331" checksum="3C5BBE7795ABAD53" modified="2011-10-19" version="1">MMMNYWMVVMVFIGVSAQESGADGKDHNGEEHTKLCAVLKEAVGMWGEGRQSLSESLKMALHRTIFGNESGGDLAKLKEKVPADYDILASPDAERGFLCGEPVDEHLHKQRGRPWSGHSAPHDLVCLCTLGKDGWPLNESNNGIDKLCGRLKDSLGGENEGWSGVHTEWIESSETLVHHAKGETQIKATWFNVTKPCLEGNRKGENLKEALKTFVDSLKPMPSTGKRNGAQLGEGNPNEDHACTGSRKYGVCVMYYPNDKDTKTWWVDLQKALIEDEKIQKERDEEAKRKQEEAAKKDTNKTEDLKSTNPTTNQTEQNKTATLHETMRKFNLTSGTHISMPSSWLLRAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8A7</accession>
    <name>F9W8A7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001156">
        <property type="protein sequence ID" value="CCD13439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41880"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389991" evidence="5">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="40562" checksum="9A89C9F2B6C03D03" modified="2011-10-19" version="1">MWGKIMALMVLLSVRCLGDRGYDDGIFSKLCDVVRKTRALYRLQEANSTVKKTLEQAIYGTQTTALFNDDGNVEISGNCGSQKMRNLLCTYHSGGLMMYGKGGCFAESLLGTIMCVCTPGSFKSNIGSLCGADTKKYNGKTWWGRWLDSKEQKELIKEVWEEVKENCPEDGGYKLQDEEKLNDLKRSLDTLRETLKPTIGLNLFYLGGSGWGGCSGSNGDSVCALYKGNVADKKSVNIPWMTKIVTTLEDLSKTLATQAGALAVTASAHSTPEAAGVVPDNRENAENAETAVQIKHSADETNEDIGLLKTKFENSGKSESSVVESSKARTTGENRTTPQHHLTEIPHITTNPNEEGSLIIKQFSFLCAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8I4</accession>
    <name>F9W8I4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_42620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42620"/>
    <dbReference type="OMA" id="QFFLCEL"/>
    <dbReference type="OrthoDB" id="1434266at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="PTHR21206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="SSF158573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLD5_C" evidence="7">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="268" mass="29501" checksum="4C443A4B0141E2BD" modified="2011-10-19" version="1">MFFEEHLDEALSREGSPVIGSGHAANSVNISVGGVVDNAFLLASRHATGDLLKSLIQATENERCAPDILPYPEAVIDGVIAQMALQNEQIRLLSAEEKQKAATSSTGISLLPFKPSDIMALEVQRAQFFLVELLRCRLRKIESLALTIHYESQSGANAPTHLRDHLSHNEVIVADRLAELITRCVRQAGLQSVPPELQQLVPNPPYAEGVEVLPLPDVDRYVFCVVLDDLGVVRLGEDAEQTVHAGEVFIVPYHTFRPYILEGRVRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8N3</accession>
    <name>F9W8N3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001189">
        <property type="protein sequence ID" value="CCD13567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43090"/>
    <dbReference type="OrthoDB" id="1083021at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38130" checksum="C096ECF137347733" modified="2011-10-19" version="1">MKKVSMYAGFSMCATLFTKELPLCEATGVYYTVKKANEEIPLAVIPVEVKNSGNDSCIVLMIRKRKGCTETAWELVRLGESLAQQDVKSIVKALQSRGLVDPPNYTFDLSRRLDDIFTDNGSDSADSLEEPDDHEISREWKKSVTGDVLLESLCNKPRVKREGRRQYSVGRSAVNLFVAEGDSSDDDEVMEDALRAVVPKYTDSSPVRYDEKTYNIGSCSDQLTQHYVSHREEYGLMAFEADSSGQLVLPSVAGSLTMDKRRMSLGETGFIRPAVPPELSSTFPFLCRRRVISRSKGGHTRGRSPKKRRKCKSRRRKGRRSKGRRSASRSSSCGSNKVKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8P8</accession>
    <name>F9W8P8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1758</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_43250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001195">
        <property type="protein sequence ID" value="CCD13583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43250"/>
    <dbReference type="OrthoDB" id="1737472at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14172" checksum="C71606C6A8541446" modified="2011-10-19" version="1" fragment="single">MENSSDYQVQPTITRESAIAQAILKRITQKAHTILKEIKRVNATRDIEKVKAEFAKVIFGEGVNKSHLCDGALKDVKDRATACGKPGAGEKGGSAGNNLVVDFFCLCAMSTDGEGIGSVCSVEVCGKGGNKPDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q3</accession>
    <name>F9W8Q3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1759</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001196">
        <property type="protein sequence ID" value="CCD13589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43300"/>
    <dbReference type="OrthoDB" id="518399at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="467" mass="51558" checksum="231D66D90B561F3E" modified="2011-10-19" version="1">MKRNVCGVLRRKLCRTPISPFISANITLRSMHYPSAAQRRLAFQQFLNRESAPFVGHDVSGEGAGEAINHCHTEVEDRKVEHNVRRRHVLDLVEVRPLQGKLEEGEEFNENERWETRPGNATREGSQPHKGRRNDQYTRRGCDIDPQQRGARDLLSLQQRAAHAVRNAKNKKLVEECRRAAMTLREIHAALQGSTTVANANACSGNNGSAVPCTGGTTEGRIVPSEAVRFQRLHQLRDTTYHLTAEHFAQFPQGFVLDFLDTIGRIVSLVGDPNMTGHGHVVRQAVRSLFMRRYAQSYPDFTSKPPGRKSRSPGSSAQAQCETLLPIHYFRLLRSTLSLPPADSLKIRGPLGTAVPVEEFCVRQLYTANNNGACSSASSAAYSLQQLGPARAVRVVSWCMRCGLSSSHPTAQGSTWISSSSTLPPVSDLRIPFGVGKEYTHALLGCLLSPTLKTATKASRRSYCLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q6</accession>
    <name>F9W8Q6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001199">
        <property type="protein sequence ID" value="CCD13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04520"/>
    <dbReference type="OrthoDB" id="247566at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="45021" checksum="023219E4975B96B0" modified="2011-10-19" version="1">MPALEKIFAERNACPKAVVSLAAVVSTGVVRDSFGMICQRLESRLASEEASPANLRKTDSELQALSATKKNAQDFFQFRAALLTAFDSISVPSSGGSDGPVPRESGSADGTSAYLLVKSFYSLLGWMLMVQPDRLSLTTSRTTPAPSSRAQNSAEPPVHVTYYDPPSGKITIERASAAFRWGLMINMEGRLIGLENALRTATPTGGELYYALQLRDDGLPIYSINGVSLRDAEDTGKGAEETEEIQTKRLEKLQEILKGKQTKVTLIVGGVPGLHDPQVVAFELVHQGGEGALGQEACLILRRASLSVDWGIKLSKNEDGQLILDGVSSSLALSSDANEFINAHIGNLHVVQVNGFGSSSRNFHEDIMRTSLFLKLRLQSVAKVGPGATEAGAQDKKGNLTRPFPPNPGPNKTPPPPPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8T5</accession>
    <name>F9W8T5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1776</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001215">
        <property type="protein sequence ID" value="CCD13621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43590"/>
    <dbReference type="OrthoDB" id="1604225at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012457">
        <property type="entry name" value="DUF1663"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07909">
        <property type="entry name" value="DUF1663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1663" evidence="2">
        <location>
            <begin position="177"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="306" mass="35906" checksum="B04F0489AD7398D5" modified="2011-10-19" version="1">MSSRDTGGLPKYRGRIVKPANQQSLKSSKRTSVESVDKFEGVTWQPMTSFERAEKNTVTAVREARDVRSSSHPTENYPPSPSRLLCIRRVSALPYSSSSYVHNAITTASLSHPSRPNLPRNETSAFLKERRTSKSSLPLSVAWASEVPTHIVANDLRHSVERRREDEVEDVCYLRFEQEEDVERQQLIIDEMEEFSECIQKMLLHRIIQTSNYKERIAAEEKMWLALQDVNDVMEKEEERRNFIVTKEIIDRRILKSRYEDNEEMEEEEQEIQHNISGEEWIHYTYPLALEKTRMEEGTWLQRYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Z2</accession>
    <name>F9W8Z2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
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        <location>
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            <end position="339"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="339" mass="37314" checksum="8051979DB0C90FC7" modified="2011-10-19" version="1">MICARNVWVAVVVIVEAVRGASEVNTGKTDHNSDKHGLLCNVLASTVSLFLSKRGGIQLQKAVRESIFGIGNRGEEDATNLKLPTDYDGQGSRKDLCGSCGDSEHHPGGSIPHDILCLCTVGNRGAPFGGDKYYSLCGLSGEHWGCQKYSAGDHYVGTGQQWECVDKSWNSGWDQPRRHTAWEKVVKPCLEKGKTLSFTDALNNLEAALNGWEHPKWGASHEGCEGNGFGDICVKYSQWCYTSTWWAQLKEGLKQIDLSEPETASSRTNANNESVENSHFSRVNRGATSLDTTHGNKRWIFSTTHREHEKDRLPLNLSSHESDSTIVSSRLSVLAIFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001247">
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    <dbReference type="OMA" id="WTEMESH"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <end position="30"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="866"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="CCD13689.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="898" mass="101085" checksum="8F2691E56939C64F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W974</accession>
    <name>F9W974_TRYCI</name>
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        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1830</fullName>
        </submittedName>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001275">
        <property type="protein sequence ID" value="CCD13764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44710"/>
    <dbReference type="OrthoDB" id="720246at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
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    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="911"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
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        <location>
            <begin position="632"/>
            <end position="666"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="191"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="291"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
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            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="911"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="935"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1505" mass="169366" checksum="8D338D4AE060758B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W995</accession>
    <name>F9W995_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1839</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_44870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001285">
        <property type="protein sequence ID" value="CCD13786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44870"/>
    <dbReference type="OrthoDB" id="1274776at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="76"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="272"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="555" mass="60418" checksum="E54CEC32D76847C9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9L2</accession>
    <name>F9W9L2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001321">
        <property type="protein sequence ID" value="CCD13914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="108" mass="11715" checksum="46924A49449DFF4F" modified="2011-10-19" version="1">MRERRPDAGEDAYEQSTGTGSHAKLPSLVYTDPTCTVGCGTPHCILLSSVTAPGMRKAATFPQAVWWEGHEPSVGCHAMGAYQQRDGYAAVEATRWVAFCVKGQWKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M4</accession>
    <name>F9W9M4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1877</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_46120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001327">
        <property type="protein sequence ID" value="CCD13926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46120"/>
    <dbReference type="OrthoDB" id="953561at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="23033" checksum="8EE0241293E55E44" modified="2011-10-19" version="1" fragment="single">MRPVHQVGDVERRRTLLCNAIVSAEAEIAQQHDAMQKLTSENERLKKEIAVASGVRYDYVKADKYAALKTEVDSLERRYQFEKMNMNELTKQYQLARIDLMQSSRMKGGVNAEQENARAVQRQLEILENRLDQALARFNDAVSYNKELRDHIDIIRGERRVFQRVHNKMEEDLRSKKKIMSERIEQSNHDLDERDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9N0</accession>
    <name>F9W9N0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001331">
        <property type="protein sequence ID" value="CCD13934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46200"/>
    <dbReference type="OrthoDB" id="1691413at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="230" mass="26579" checksum="219ACC0EEE58BF1D" modified="2011-10-19" version="1">MTGMPKTSQEINYSADSQHPTVLPLTHDNIVTHVLDRESYSKLDYDEIMNIFEKRAEIAWQKTEAADRAKERGYVEKENIRGLGFYRKSEVLKKTVYEEIDIRQTFKNQPDIIHELGQMFHAFRMTFGDLMVYILLCRIRQLSGEPGPVPHITKIAYSAAKPIKEKGDKKWDKYWEETEKKYGGDSIWAKPGEEGTADYDWNEETDEKHGGTNGSIWAEPGEEGTADYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA24</accession>
    <name>F9WA24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1923</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001379">
        <property type="protein sequence ID" value="CCD14080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47470"/>
    <dbReference type="OMA" id="CRRHPPN"/>
    <dbReference type="OrthoDB" id="1389025at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="857"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="950" mass="106764" checksum="33A2E95E82330D7B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA48</accession>
    <name>F9WA48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001388">
        <property type="protein sequence ID" value="CCD14104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NTIYVTE"/>
    <dbReference type="OrthoDB" id="1069956at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021259">
        <property type="entry name" value="DUF2817"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10994">
        <property type="entry name" value="DUF2817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15016" checksum="CCCD823FA62AE291" modified="2011-10-19" version="1">MDLHSESGTAGRETIIADSPEGKALAQSIFQSSVQLRGEDGAYQHIRGLVKPTDVLGKRKGSLVVEEAFATANFPFMLRAAFLERAADKHARGSFVHEAMRQWLRDAYFPQTISYKTSSLSKGVTSFNSAWNYLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD9</accession>
    <name>F9WAD9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001419">
        <property type="protein sequence ID" value="CCD14200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48480"/>
    <dbReference type="OMA" id="WWERPAY"/>
    <dbReference type="OrthoDB" id="1141714at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="673" mass="72586" checksum="4A6A07ECFAB595B3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV9</accession>
    <name>F9WAV9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001489">
        <property type="protein sequence ID" value="CCD14381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49990"/>
    <dbReference type="OMA" id="CAGANTD"/>
    <dbReference type="OrthoDB" id="1668830at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390076" evidence="5">
        <location>
            <begin position="24"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="95"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="46732" checksum="BD0B0FD646F17373" modified="2011-10-19" version="1">MDMVCFVNIIAVVIFSLVLRVRGNNGAEVRSIDNAEQFTLLCRIYNVAKNPPINHVDLPDLLGIANEMDALNTSMAEKKVLNETELAGDSVGAKLQPNTTRETAVAQAILSRITQKAHNILEEIRKVNFTRDIENVKAEFAQVIFGYGVNESDLDKGALSGITGRAEACGSSGLSHKGSHAGENLVVDFFCLCAMRTEKDKEGIKEVCGVEVGDSKQNAYHGWGAAAPSGASSMWASVKKGCGKLMHEHPKSTTKGHEVLGDFWRHLKSGGIYRWGDSNKVDGTNRKEGMLGTGMVKKGGGGADLLCDGSRGKSTKTRKATPENPGGICVYYGPESEWENIPWLKNLRRALNNADALNNKTATIQRAIQKLQALLHRAEQIYETTQVISEIQNPVAQTNLQTAAKRLTAYSSAWRYNLHHLILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX4</accession>
    <name>F9WAX4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2027</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001494">
        <property type="protein sequence ID" value="CCD14398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50150"/>
    <dbReference type="OrthoDB" id="1708255at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="202" mass="22228" checksum="630CED1463772AC7" modified="2011-10-19" version="1">MHCSPSPKIEVTTHRAATQPRHPRIHWLRRVVSLPLSMSLRDWTVGPTNAVFLFPLIHLPATAHNRRPIIPTPWKVCFPLSADTLVRLLLEHLIPQSESHCSVPKTCTLYICVPVIMLPSTNVLLKPGKVFSAPSGCLLLWWLVLPCVLCPRLVASRSQVAARSRPLNSASRNPSAGRSAGIQCCRAVSKAPSVTSACAWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB58</accession>
    <name>F9WB58_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001535">
        <property type="protein sequence ID" value="CCD14489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50980"/>
    <dbReference type="OMA" id="AYIRRED"/>
    <dbReference type="OrthoDB" id="1661045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="51377" checksum="E9AC99BCCF4217D5" modified="2011-10-19" version="1" fragment="single">MERSGGLSDMSLHDFLMEHFGETFGSPCVSMRVFMDNPTLCVSDEAVLRRITNSSPYRGYKAMREGMDRLRAKGIFSLYQWESAAAANEVEGVDDSVKGKLDGALFIARCNEERMRVRRASSGEELDGAYDSVFNARWSYVVRSGEYGEKWLGMGVLRVSEGKQPHLWSEEQWDVEPESDPWKPWEGDVVPGVSSKLVMTVLSSEKGLPFRLFSADEIQDKGTVTLAVYNAACDAYIRREDLRVWHNVKKSINEWLSDRGCVHPFIVIGTPDIGKSFATGSSLLYQLLHYPSDNLKVVVYFVEGKAYIFHREERRVVYYEKQRVALRNVDDMIRRGVKGYIIFDISGNSVHIEDLPYAWGIVLISSPNVKKFHEFTKQLHRTLPTYINCYEDTEFKAALVWETRQQVANNQIKLEDVNIENDWKVVEWRIHMIGPVPRHVLVDEGYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBD3</accession>
    <name>F9WBD3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 209</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001565">
        <property type="protein sequence ID" value="CCD14565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05460"/>
    <dbReference type="OMA" id="TELECFN"/>
    <dbReference type="OrthoDB" id="871292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394832" evidence="1">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="388" mass="42202" checksum="29DD491F137DEA54" modified="2011-10-19" version="1" fragment="single">MVVLCTFCALLSILTAARATILRYDVEMVHAGNTTEESKMWAEFVDHGAPAAESVSLLGVVDGGHHDLTLSSPFFSSGSVRWYVSPYVFLTTSPLPLCTSFCTKSVLGTLLKDGEIQTGVGTHGMSMIAPYVADLSPSKTVSIFPRARTEGVVKNTHCQIVEYTDVVVKDCPSEGNTMLTTQIEVCTDGTIVMRYKKLPKCGMVTAGIALSDAERSNYTFDIDRDVSAIRYKPVSDNCSGIETELECFNGEGCLWCGSTGTCVSKLIANLKAPSGTCYNASRLLHGYYNVSISQRSGLYLEETLRFSKVTTTSSVVFLSLGFNFPFYTKNQKNRRTSLVNILASGVISVFSDRQDCETVRNLCTRGNYSYAIMPLAANQNWVSGTSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBE5</accession>
    <name>F9WBE5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2096</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_51810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001570">
        <property type="protein sequence ID" value="CCD14577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51810"/>
    <dbReference type="OMA" id="AVFTMMP"/>
    <dbReference type="OrthoDB" id="1313171at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCRF" evidence="3">
        <location>
            <begin position="124"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="474" mass="53140" checksum="41405B7FA583E6B0" modified="2011-10-19" version="1">MRNTSLLMFGAGGTLGGVKKLSSSQAVPYSNWLLAEGSRALVNSIHHPLVAEYFLRLHEVHTKLQKLQDSSDSVFSPSKLDKTHFNHVMWNVQYSDEFDISEKLSHYLLKINDNVILKDQLRSQKCLSEEDRDILRMVEEDIEELLCNVRNMDSEVNAAIIRRVESGDALGSCSNTWELDVTGKAGGEEASLFASELADMYRAYASEIRCWSTDIVHNEGDGGAISSAPPTTGSCTVKVRVKGDGVYRNLRHEIGVHKVQRVPITDQSGKMQTSTAVVTLMPVLDPVSVDIHEEDCNIEFVRGSGPGGQGMQSSSNAVCLTHRPSGISVKCHQSRSALGNKELSLQTVAQQILMRRIKEQNSSLHEAWCNQWSSGERSDKMRTYNYPQNRVTDHRLGKDYSLGSFMDGGAGLRGLHDDLNAIDEFKQRNNHQKHTFPHKKQKNEKNIFFAFFRENFVKSVISHRECKKTVQTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBL6</accession>
    <name>F9WBL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001597">
        <property type="protein sequence ID" value="CCD14649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52480"/>
    <dbReference type="OrthoDB" id="731783at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390111" evidence="1">
        <location>
            <begin position="26"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="20160" checksum="D5EC7A56FD349BAC" modified="2011-10-19" version="1" fragment="single">MELTSTASWELLLLCWSLAAIAVAAVRWHLQGRRGTGEKTLKEGTLDLSSTVESSRECCCACNTAGTVAMSNIGKEACCKQREVKKILVAYATQSNTAYKLSNKLVALLSVALREKEAVHPAGGSLAAASAGTCCSQGAAMSSVSTPEIKLLQLKEEDGQCSSEHLLESGDYGLVVFLVSTHPGGNAPGPSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBS2</accession>
    <name>F9WBS2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_52990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001622">
        <property type="protein sequence ID" value="CCD14706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52990"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="566"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="662" mass="73583" checksum="4D9EF62D1A726A96" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBY6</accession>
    <name>F9WBY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14252" checksum="772A230CE51D581E" modified="2011-10-19" version="1">MKVCEAQYAEAADKVFSPQHAIYSKLEKVRHTYNTIEVAVKPHEATVLQWAKEVYFNTTAPGVLKAEAPKEERKVHTMRRVQRFNGYDYQAWKDGPVALDVSSGAEALVCPRTGKKVRRSLCVVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC00</accession>
    <name>F9WC00_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2165</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001647">
        <property type="protein sequence ID" value="CCD14787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53730"/>
    <dbReference type="OMA" id="TWNNDQP"/>
    <dbReference type="OrthoDB" id="889671at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033036">
        <property type="term" value="P:macromolecule localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="PTHR10926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43382" checksum="BD6FEAF225D5A8A2" modified="2011-10-19" version="1">MGFVKLLIQQRLPAWQVNLTAPAVSIAFCVVAILCAALGSLVHLANVKVVEISRRYDNKFCKDILSKKAVNDSGWVNVSKGCIAEVEFLVDEELQQPVFLYYGLTQMYQNHRRYRNSRSDAQLMGANPRSIPDADPLAIPGDINGLKHASIEYSGEERHYSDFVYVPAGLVAWSMFNDSFTLYKRSDSGNGSENELICNGTDFSRSTNLPLGWSANNKCHKKGIAWSTDVAKRFVKPNWNSEGLIWTAPRTEYGESSSPTTNDTCWNNGWYAGEPGHLIPVTTDEDLMVWMRTSPRPTLRKLYRVIDTTLTKGRYVMIIHDRYNVASFGGEKSFILTSTSFLGGKLTWLSFTYFAVSGLAVLFSILIPLSSWLCSHRSRRTVKVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC25</accession>
    <name>F9WC25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001659">
        <property type="protein sequence ID" value="CCD14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53940"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394666" evidence="5">
        <location>
            <begin position="19"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="287" mass="31369" checksum="44175D0E5250FA81" modified="2011-10-19" version="1">MWRRVLLVLFVVGKGTLAAEGSNQEVYKKLCDITKGVKGLMKQNGEHKGSLQEALYGEKKEDPFVNGYFTGGSRCEWVYPPSRSTYCSHIQPGSTQAKNPGCFGDSILGTLLCTCVRGQYNEQDLCGLGIEQGSTGWGGWNSRPQDLFKKVLEKIKENCTAPNTTVDIAGHLEDLKNAVNEIKNEAKQKNFSNGKDGHYLGSGTTTTRFCDGSSAQDACVTYPEKSGNEPSIPWADKILDAINKARTQQQGNYKNAAITSGPDHHQDDQERSSETDTGNDEEGDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC44</accession>
    <name>F9WC44_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001664">
        <property type="protein sequence ID" value="CCD14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54140"/>
    <dbReference type="OrthoDB" id="1711019at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="21110" checksum="899D2AB465130AEF" modified="2011-10-19" version="1" fragment="single">MQRMTLPAMGRTGSHVFCCSSFMWSAVRGNSIKSSAPCSTCSTSSFNEATSIFERFKSLKHLLTLVSEVYELFLLSRHITDGIAVVSHVMLRRHHHCLAMLFHTLPNMKQCTRHVCVFCFHFYLYVCPNVSLMVTSTRFLCSSPRCRHCDTTSASLGPNTERTTNVAAEKAAGDADPEAATGRSVPSGHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC57</accession>
    <name>F9WC57_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2189</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001673">
        <property type="protein sequence ID" value="CCD14849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54260"/>
    <dbReference type="OrthoDB" id="1720571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16989" checksum="63C70911DF68980D" modified="2011-10-19" version="1" fragment="single">MNHQWHDVLIVDDEGDKAFSDAAPLLLEALEIVSHTRMLHFSLGVDCLAAGLQSVKDDRFTYRAKMGEAREMRSMMASLLDSVHDSFSTIMETNKAPQQTGKGRTTDYRSLLRCDGGLIAPRSLKLKTLLIWDPAFSYKTFFGRFNRLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCC9</accession>
    <name>F9WCC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13773" checksum="83BF22180E7D7685" modified="2011-10-19" version="1">MILERGKMEGGLAAQRRSVSYAGCEARRKHPSRRLPWPKSPRTPFALHASPNVPGRAPLRIPQFGEGCYYETQPYDIGWSQQIKSLYSSGGTLTFPYEGVATRGAFLGVCEVVRSVSLGAELFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD7</accession>
    <name>F9WCD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_54990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001704">
        <property type="protein sequence ID" value="CCD14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54990"/>
    <dbReference type="OMA" id="NWYETNN"/>
    <dbReference type="OrthoDB" id="219167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044591">
        <property type="entry name" value="RUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46562">
        <property type="entry name" value="PTHR46562"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="946"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1256" mass="138846" checksum="D06420F4AD842395" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCI1</accession>
    <name>F9WCI1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001726">
        <property type="protein sequence ID" value="CCD14974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="16850" checksum="873093CFFA9F4752" modified="2011-10-19" version="1">MTLLGEREGTERIMKWRAARRFDEMRGFNFHESRLAPLNNFHAHPLGTRREWHIIFISREKLAPLLFLPPLLAFFLFLFFCVRYSFYYAALFIPLDLFFIYCHAFLFFFSPYHCTALCCRAPSHIPSCWCAVVYICSFKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCK9</accession>
    <name>F9WCK9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001736">
        <property type="protein sequence ID" value="CCD15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55690"/>
    <dbReference type="OrthoDB" id="1740757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18248" checksum="CBE241411DEE9F0F" modified="2011-10-19" version="1">MKTIFHGHFSYGILSPSLLFECHPQQLFVVPHSSSMKQVLLDKGNRLSKKSAYFRRLIEKRDSLSSPCSSLKESMSPSSHPLSPSSERLSSNTFPPTLLASMVEYSLPNPVHYFKKNELLRNIQWGELGILERVVYYQRSTKQSSLITKSNQVGNMAHPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT6</accession>
    <name>F9WCT6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2266</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001760">
        <property type="protein sequence ID" value="CCD15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56470"/>
    <dbReference type="OMA" id="DSHRCAL"/>
    <dbReference type="OrthoDB" id="1654948at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="806" mass="90134" checksum="67536DAC89E0A0E4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD35</accession>
    <name>F9WD35_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001816">
        <property type="protein sequence ID" value="CCD15184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57330"/>
    <dbReference type="OrthoDB" id="1679214at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394686" evidence="5">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="56"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="353" mass="39383" checksum="9E05A7AE4C1F4FBD" modified="2011-10-19" version="1">MVIMRMKVLMVIMLIIGVVRANEGGSDHNGKAHKALCDVLKVAVRDWEEVQKRESMDPLRKALGRTIFGSQDGGKVDGLKGRFPKDYEEVKGSLSARYFWCGERHEGSVLSVGKPPRWSGHSGPHDLVCLCTIGKDGWPLNDGKVKLCGQSKDTSIGGTKGWSTGGSGQGKEKITDTWGKVVTPCLVLGEVGETLKRVLKTFKDIINKTITKDGKNGYLLGERGGSEYPCSGNEEACVMYYNDTKTTGEQYHVPWWVELEYAIKKEEQKEQKKREDEKRKQEEKNHQKPKHQKQSQQHQDAPRKAALRSSTTKTTETEQGNPENISAPLAAIEDTSGTRMTQPLWLISTAFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD37</accession>
    <name>F9WD37_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_57350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001816">
        <property type="protein sequence ID" value="CCD15186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57350"/>
    <dbReference type="OrthoDB" id="1668163at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390167" evidence="9">
        <location>
            <begin position="24"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="95"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD15186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="43213" checksum="B67C89F7A8DE9DDD" modified="2011-10-19" version="1">MLQAMKALGIISMMSVFCSEVLSAGSYHRQSIPTEAGESICSLSRKLKDVTPWTQEKIAALRRTRDAYASKLLDWQLHFHGSLECEVNESNLETIRTDLEKVNEELQKLPAKAIRAGSLAAKSAGRLDEFITVFANARKSNFMGTVNYCLGSKGDPANRRDLLDCFPEGEKLEIGEANLAKIPESMTNAKELNLTAAFKSVTHGSVEAYFNRIHWDDTYAGCNLINATSGFIGSALNDRLWWGGGIFTIGKSFDGKMEKTKFTAGEATDASGDNSKAFWTEKPSEKIPHLKKTLAAFQAFKDATTKITQKFSEIEKIEKKIEPCLSNETMEDRPTQSCFKNAVKLNAELQAANALLARYHKEKGPLPSGSPSPHAQGVMHFLYLIAFLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD84</accession>
    <name>F9WD84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001836">
        <property type="protein sequence ID" value="CCD15235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57770"/>
    <dbReference type="OrthoDB" id="1681964at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390197" evidence="5">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37722" checksum="53ECD9EBBB8C4966" modified="2011-10-19" version="1">MMKFWTVVIVIVVGVAASAVEKNHNGAQHKALCDLMKAAVGRWGEGGKNLSESMSKALNRTIFGNEGGGDITELRKQLPNFYDEVLKGNAARRTACGVQESGQSAPYDMVCLCTKGHNGWPLNESGIETLCGKPKTALGGGDEGWSDEDWSDDEWSDKDRKKRQKELSATWSNVVSPCLEGDIGKDLKKSLETFKEQLVNKSDKFVPDMYQLGKGEPESYSACTGTRKTGVCVMYYNGTQKIDQRPWWEDLEKAIPQEETFQEEKKKREEEERRKKEEAEQDIPQTAAQTSAPPTTNQTDQQHRNANFTTHFHRLNMTSGTLIIPPCPWLLSVPFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDB6</accession>
    <name>F9WDB6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Charged multivesicular body protein 1a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Chromatin-modifying protein 1a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_58040</name>
        <name evidence="8" type="ORF">TCIL3000_11_2840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC94890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001851">
        <property type="protein sequence ID" value="CCD15269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.2840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58040"/>
    <dbReference type="OMA" id="KFASKQM"/>
    <dbReference type="OrthoDB" id="1441797at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029888">
        <property type="entry name" value="CHMP1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="PTHR10476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476:SF17">
        <property type="entry name" value="PTHR10476:SF17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC94890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="210" mass="22675" checksum="3D4AA48B98C71FED" modified="2011-10-19" version="1">MEDMNSNAMLDVVHGMEVAAKQLGQSSTETQREAEREKRKIQKALERSNTEAARTYAENTIRKRAASVSLLRLATRLETAAGQLHAAVRRRTVTDPLRRSACGMGKVLRVLDPVRVTSALSEFEAHINGTGLGTVAAVADFGAVEATNVSTIEVESLLEQVAAESEFGADDQMEAVTMFLKKRVGVGLDAGACVKEQEQLPWKHLGVGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDG9</accession>
    <name>F9WDG9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001865">
        <property type="protein sequence ID" value="CCD15322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14867" checksum="512CC75C32E4EB39" modified="2011-10-19" version="1">MDGNRYIRRNFVHWVFLLVAFILGEAYFIIVFSVPKQTNKQTKKKCDAPVRSYTKQPFSQPNTKLFLMMDDDRIIMCVVDRTTSAAHIHTHKFMGNFLPLVPCRSERSVVMGVVSKCGAVAKAQTFSFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDT9</accession>
    <name>F9WDT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 2404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_59630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001913">
        <property type="protein sequence ID" value="CCD15443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59630"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37858" checksum="56E3BAC71AFBEDDA" modified="2011-10-19" version="1">MASDTSFATKTYVCVTCFILDVCAYWAVETRFLAPIFMASHYKYITGNEHAEPSSVLFWLNIFTFHNLILFAARALAERPELERLVRGWGLRLRFTLSIVLILAELALIFFLPVLSMSPPYAIVSLCFTTILGTIGKQFLGRTTHTLWDFLLTEKAGGVIRLTAFLVAIVHATLCIIVVVPGTTGESRENTLSLHTVVYAVVLVIALVMALSLSLIRCTREGFRSAQRAAQKGRVEGINHLIERVGKTRKTLESIRVRLHAQSDPILRNEVQKEHQQAKRETVEAQEDIRRRLKDEASISALSRLAEFEAEWARPLPPEASSDGGNRDVAQSPQAPDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDW4</accession>
    <name>F9WDW4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dual-specificity kinase</fullName>
            <ecNumber evidence="5">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TCIL3000_0_06150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01001921">
        <property type="protein sequence ID" value="CCD15469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06150"/>
    <dbReference type="OMA" id="KASEMPF"/>
    <dbReference type="OrthoDB" id="870358at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="108"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD15469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="47210" checksum="ECC1A25BF11E62FB" modified="2011-10-19" version="1" fragment="single">MEATRGLAERHGPRASPQAPPLHTKPPVRRNSRRKLLHDEAVPTSDCYSAFLTAYERDEIKNYADVYYAGQNCERKIQAPVDGSNNKGYDDDRGDYIIRLHDHIAYRYEILQVLGSGSFGQVVKVMDHLKNVTVALKIIRNRRRFATQAKIEVQILSHLKKGDPSGIYGIVQMIDHLTFRSHTCITYELLGCNLYDHLRQRRFRPLSLDVVRKIGAGVLVSLSYLWRENIIHCDLKPENILLKSSSDTAVKVIDLGSSCFENARLFTYIQSRFYRAPEVLLGLPYSKCIDLWSYGCVLCELATGYPIFPGENEQEQMACIMEFLGPPPRDMILRSPRKNDFFESNTDYSPKLIPNSKLKVRFPGTKNIASFLGLSERDEFVDFVKLFFNWNPEVRCSPRRAMKHPWIEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE16</accession>
    <name>F9WE16_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001938">
        <property type="protein sequence ID" value="CCD15522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60280"/>
    <dbReference type="OMA" id="ENATHEP"/>
    <dbReference type="OrthoDB" id="229980at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="798" mass="85627" checksum="B02BD17C6D0BC83B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER6</accession>
    <name>F9WER6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_07930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002056">
        <property type="protein sequence ID" value="CCD15782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07930"/>
    <dbReference type="OMA" id="ANSHIYE"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="119"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="468" mass="53720" checksum="2FA36883266E9108" modified="2011-10-19" version="1">MRGSTNAYNTLLVHTGFLFLVVHTKGCKVMVTDVVEAFLLYAAVVLHGVAQLQSHNKEEFRVMCKLLSLHEKGIPPPQFENVEKENEIIEEMEFLERATGPDVSNFESSVWKMKKFLKEHPPPEGEEARKVANEKIRQLLQKAEDVKKRSDQNRKSAIGPWETAQLKVLQAVYGEQAKNLTKYLDTHVNFTSNTEDIFESNTTANYSCGADIAESSNGKTVGKTLINDIFCLCVGECNWGNPCHDDIGSPNKASYKRTKKSFNCSTDTNKGEWTKIKYKAGSKTALSFSESWEAIKKSCDDVLRLEKFDIEINATLTEFEKLLHGGKSGSGRMILGYKFNHTEISYKCIGNVSQLRSWEHSLGYQPPSEHQTCVDYTHTLKTIKDIPWRKKIREAMNYTTEMEYIVAEEQTYLAELIKLKNSAWMAYNKEKDEEFYEIENYDYNKEEFADFPKTHLLFYTLMYFIFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WES2</accession>
    <name>F9WES2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002058">
        <property type="protein sequence ID" value="CCD15788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07990"/>
    <dbReference type="OMA" id="LSDYPMC"/>
    <dbReference type="OrthoDB" id="1243954at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="25445" checksum="0528D09C77DA4BAE" modified="2011-10-19" version="1">MNAKGTEAINEKVREFLSKDAVEELRNLSDRTESRVRHGLLPRDYLQKEHKKDHQTANIAHEEEVNAYISVNRTWRENFFILRDFEYWRLRAEFYPYIRRSDEQNDNFFIRGIACHPRLSDYPMCRKPIQDYFVCRDKNKFLQLFNMCAPMKEQFCACINEVFVKNHERGDKKFNAQRDEYFEEQRGRRLSKMMAHAEESLEKRRKMQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEX6</accession>
    <name>F9WEX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002073">
        <property type="protein sequence ID" value="CCD15842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00960"/>
    <dbReference type="OrthoDB" id="1705148at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="300" mass="35585" checksum="12FDD34C152FD37B" modified="2011-10-19" version="1">MVGAPPRPLVGTPGGVHFSLVIRNGTLGGLIKERGRGLSKIYYTQKIFLLKKFSFSFFISFFSKTLSLSESQNFMKFPFLPNSPFCQISIFCQISIFCQISLFSRNSIFHEISIFAKFPFLRHSLFAKFSFLRHSIFSLIPFFAKFPFFHKIHLFAKFPFFHKIPFFCQFPFFIKFPLFCQIPFFCQFPLFAKFPFFAKFPFFHEILFFTKFPFLPNFHFLPNFPFFTKFYFSRNFHFCQISLFATFSFCKILLFATFHFFANSIFCQIPLFCQIPLFVKFPFLPNSPFCQIPLFAKFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFI3</accession>
    <name>F9WFI3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flap endonuclease 1</fullName>
            <shortName evidence="11">FEN-1</shortName>
            <ecNumber evidence="11">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FEN1</name>
        <name evidence="16" type="ORF">TCIL3000_0_10230</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL3000</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
            <location evidence="11">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
            <location evidence="11">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="11">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CAEQ01002148">
        <property type="protein sequence ID" value="CCD16055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10230"/>
    <dbReference type="OMA" id="GSQDYDS"/>
    <dbReference type="OrthoDB" id="1094524at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="PTHR11081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="XPGN" evidence="15">
        <location>
            <begin position="41"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="XPGI" evidence="14">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain" evidence="11">
        <location>
            <begin position="166"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="11">
        <location>
            <begin position="380"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD16055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="492" mass="55669" checksum="731ED1C17126C002" modified="2011-10-19" version="1">MPTLNSLLRRADLPFVSCVISLLILSRLMPLQFTALLLGTMGVLGLSKLLYDRAPGAIKEKELKCYFGRRIAIDASMAVYQFVIAMKGFQEGQSVELTNDAGEVTSHLNGIFFRTLRMIDEGLRPIYVFDGKPPSLKNSELDSRRQRAEEAKHEYEKAKEEGDDEAMEKMSKRMVRVSREQMDEVKTLLQLMGIPVVQAPSEAEAQCAELVRKDKAWAVGTEDMDALAFGARVMLRHLTYGEAKKRPIAEYHLEDILELAGMTMEQFIDLCILLGCDYVPKIPGIGPHKAWEGIKKYGSMEAFLESLDGTKYVVPEGFNYVEARNFFLHPEVTPGEEIEIQFREPDEEGLVKFLVQEKLFNKDRVLKGIQRLRDALAKKTQGRLDQFFTITKVARPAAAELTAAAGSKRSRSAVSCLGCSNVKHLPVTRKRSKSNTRRSIDHVLYTNYPFTIFLFIYTYTYTYTYIYIYLKLAIDPCPLHSSIQPCFSDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP1</accession>
    <name>F9WFP1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002174">
        <property type="protein sequence ID" value="CCD16118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14343" checksum="608E02068B43C326" modified="2011-10-19" version="1">MKKDSFIAGETKDKDTNDKALWTASPHTIPHLKKTLAAFHDFKDSAAKITQKLDEIGKIESQIEPCLSNETTEQGPTQSCFQNAVKLNAELKAANDLLARYQKEKGPLTSASALTLRPSVMSLWCLIAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG47</accession>
    <name>F9WG47_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_01410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002229">
        <property type="protein sequence ID" value="CCD16280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01410"/>
    <dbReference type="OMA" id="FNERRYI"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="45621" checksum="B886D36E4CD08E6E" modified="2011-10-19" version="1">MERRMTRARSRKPVVGLVTIAFCFCFLVHFLSTSQVSTGSVTSLEHAASPRPSGVVTRAPPAELTRNYPDWMREALAFTPAAAIRKWQHIDYLLVLGIPSVDMLERQRRRNLQRTTCWQYDGVARRANGFTGAMLPLYVLARHPSNGYAYTDAMRREVLRWSDMIALPMYEGKPSTNKKVGGGGKWGTEAEIGMSRKTFYWFDFALRMFPNASYFAKGDDDMFLRVPQYLADLRSLPRRGLYWGTMGHLAVDGYRFTYAFGALYTLGRDVAERFVSYRPLRTFINVPYSGIRWEEFNAVYLYAEDAMVGITLKRAGYSSELFHVNEKKCSFHELHAGFLVRPVSPSSVMVHHVKEEDYGALMKRFNDGKVVAPRKLEDTNRDAGVKTFGCIEAGTAAGGRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGP3</accession>
    <name>F9WGP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 524</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13990"/>
    <dbReference type="OMA" id="DSQMAYT"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="91"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="500" mass="52737" checksum="C810BDDB4B681CFF" modified="2011-10-19" version="1">MLLPSNGTVNFYPSLSNTGLRQEHTSWMTFNTKSPLAADPEEGSLPTGAVTGTPGAQGEELKPGGGQHHGDAKEGGTRTLASCITTLIPPGGMVSTVFNLSSICIGAGILGLPAAANSGGLIMAFIYPLIIVLVFVQSLYCIAAQVEKHSLKSYEGMARVLLGPRAAYAAGMLRVLNSFGACVAFVISVADILVAILQNSDAPDFLKSVTGNRLLTLGVWLCCMLPLVIPRQVDSLRYISTVGIIFCFYLMGVIVVHSCTNGLPENIKKIHLSGGPSDDGIHLFGTGNKAIEAPAVFTFAFLCQVASIEVYSSMAQPSVTRFTLYSAYAMAMCFVLNVATAFFGYLDFGSKVTGSVLPMYDPVSQPAIMIGYIGLVVKLCASYAILMFACRNGIYNVIGRDPDTTAFWEHCAVMVVLSVIALVCGLFIPNINTVFGFVGAVCGGFLAFIFPALFMMYGGGFTLQKVGPLCYTATYALLISGVVLSVFGTVATIYGVATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGQ5</accession>
    <name>F9WGQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 530</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002304">
        <property type="protein sequence ID" value="CCD16492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14110"/>
    <dbReference type="OrthoDB" id="1730620at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22155" checksum="C9BB53FA080453CF" modified="2011-10-19" version="1">MRVYIRMWVCVVRGCCCCVLVCVRCPSFVRIIPIRIRPGVVCGVCWGSRTWWGAAVVPAAISKTRLGARTCPNTRPPCRSLSLVLRGCLRLCARPAGARKKEVVWRRRRVLMPPDAYCVRTGSLFSLFFSSSSSSFPSLPTCVGRVEEEVCVFGGRRCSGRNMVSACVCTQVCWSRLSQRVAMDDLASYFVEERSKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGZ2</accession>
    <name>F9WGZ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_14910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002356">
        <property type="protein sequence ID" value="CCD16581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14910"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389129" evidence="5">
        <location>
            <begin position="28"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="40637" checksum="19F69F6D723BC029" modified="2011-10-19" version="1">MKVLFGMRMKAVVLGMVVVLSVGVSVGSSYNEDAFKALCEVLRHAEKVLNTTAISDPSKNGLEHALYGRPGGVLRVENGKVSVKGTRKCQSNRGLLCTYYAGGSGTYGCFAESLAGTLLCTCTPGQRGGGGRVFCGLDNLKNGGIWTGAHVESRKGLFQDVWDQVKQKCLHKSEDEKSSGVELSQLEESVKALREQLRQRNQNIFYLGDQIGYNGCGGTSRNDVCAAYHQEKGKDKHSVHIPWADAIKNAIPDLKKALMPKAPEAASVSTTHAPSATTTTEAQTIFPTKPSDPSTTTNTTEQGNTEDGHHTETEAPAHQSSSKSRHRQSTTEGTVATSTAPEETSTMGEPGILDPTAAPLFSPDGADILTPLGLFMAASSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA4</accession>
    <name>F9WHA4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_16000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002403">
        <property type="protein sequence ID" value="CCD16694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16000"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="57"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="390" mass="41885" checksum="CE368308B169266A" modified="2011-10-19" version="1">MFSFREVSRMKLFLVLGMKTLVLWMVLSMGMSVGAQTHDGKDAFNALCTVLRHAEKVLNTTTTSEPVKSEMEKALYGSRNGLLTVQQGRVSVTGTCKGHVDRELLCTYSNGGHGCFAKSLAGTILCLCTPGQGGSGWCELPTLGSGNWYGDQEISGQRVKEKTDLFQNVWDKVRWKCIPGTEVKQSIDKEVDELKKALDAFLEKWRPIGRKVVNLGGQAGGNAPCSGTTLSNVCASYYTRGRPPQHVEIPWLTAMLVAIESLKQHEHATGAAPALPSVSGNSQAHTEPDVSGSPELSESTQPTNTKEGESTEDMHLTRAPLEHQASPTSMRKWSTTEGPAGIGTPSDNTSPLEDTLPTAAPFLLADGATLGKPLGSTLFQPLGLPLTVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD7</accession>
    <name>F9WHD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 632</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_16350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002417">
        <property type="protein sequence ID" value="CCD16730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16350"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="38009" checksum="5D06AFD5263A176D" modified="2011-10-19" version="1">MASDTSFATKTYVCVTCFILDVCAYWAVETRFLAPIFMASHYKYITGNEHAEPSSVLFWLNIFTFHNLILFAARALAERPELERFVRGWGFRLRFTLSIVLILAELALIFFLPVLSMPLPNAIVSLCFTTILGTIGKQFLGRTTHTLWDFLLTEKAGGVIRLTAFLVAIVHAMLCIIVVVPGTTGESRENTLSLHTFVYAVVLVIALVMVLSLSLIRCTREGFRSAQRAAQKGRVEGINHLIERVGKTRKTLESIRVRLHAQSDPILRNEVQKEHQQAKRETVEAQEDIRRRLKDEASISALSRLAEFEAEWARPLPPEASSDGGNRDVAQSPQAPDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHH6</accession>
    <name>F9WHH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002438">
        <property type="protein sequence ID" value="CCD16769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16943" checksum="BEA6AD64288841F0" modified="2011-10-19" version="1">MQNCFCNNYFMFFRVIFSFPSPAALQNCFCNNYFMYFRVIFSFPSPGALQNCFCNNYFMSFLVFRHPARCKTVFATIISCFHFSFPSPGALQNCFCNNYFCVIFSFPSPGALQNCFCNNYFVSFLVFRHLARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHM2</accession>
    <name>F9WHM2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="3">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_17140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01002460">
        <property type="protein sequence ID" value="CCD16815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17140"/>
    <dbReference type="OMA" id="ICEDAFA"/>
    <dbReference type="OrthoDB" id="134699at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="6">
        <location>
            <begin position="631"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="775" mass="85692" checksum="04F7D43D1D40376E" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI01</accession>
    <name>F9WI01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 714</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002507">
        <property type="protein sequence ID" value="CCD16946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18270"/>
    <dbReference type="OMA" id="WENAFTA"/>
    <dbReference type="OrthoDB" id="1086224at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1121" mass="122725" checksum="3720683E0A802B2A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI02</accession>
    <name>F9WI02_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 714</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002507">
        <property type="protein sequence ID" value="CCD16947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18280"/>
    <dbReference type="OrthoDB" id="1612038at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="291" mass="31760" checksum="EEAACA1F150C5D44" modified="2011-10-19" version="1" fragment="single">MTLAAGCNSPNGLQILRALFPYATETQLEAGLESGRDVKEAVKYVHTTVNAVRPHRDCWLVESAGDTQSMGLIDATRVKTVRENLSARKKAFEKCHLTATSQHDGYNDVVLVFTIDTAQWDNSATHSPVVERGADTASRGSSHERDDGVLHEASDVCRIRPRWVGVAELCKWGGGKEGSLSCSCHEHAPDRLDGSQKPGALSRCVEPIDDNVNRAVVDGTDLNTGESLFGNILCGTDVNCTGPITLLDFTLAKEREWNAVKEKLAPWADVFCRSSGCFLFRELVLSRAQMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI45</accession>
    <name>F9WI45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_18590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002527">
        <property type="protein sequence ID" value="CCD16990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18590"/>
    <dbReference type="OrthoDB" id="1724288at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394790" evidence="4">
        <location>
            <begin position="21"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="21"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17457" checksum="06B7EB4F3ACCC3F5" modified="2011-10-19" version="1">MARFMNVIAIFVVMGSIVRGDKEQQIDKDENIEPFSLLFRIYNVATDPPINHVDLQEADKIVQEIDALNTSLMEPKWVNKTEKLGSGVSAQINPTTTREPAVFQLSLTQISQRAHKILDGINKVIITENIEKAKAEFNKVIFGGMGMKIICSWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC8</accession>
    <name>F9WIC8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002568">
        <property type="protein sequence ID" value="CCD17075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19280"/>
    <dbReference type="OrthoDB" id="1715610at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21996" checksum="53871F4C4380EA2C" modified="2011-10-19" version="1">MHLLTRCGSVRGREEDGKGHDGKEKDILTHNIVCMCPSSSPSGRIDATCYWAFPPNLFCAPLLFFGCLNRYLHHSGRLSTFSVARPPWGYKMLLVTIFLLLSLSFTPSPLLCILSLAPLYRISFLFCFQILASSRCCLPESQYGSKCALVILFFCLLCVTEQGESMYLVITPATHSPSFPFFFMKLLLPFRSLSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII1</accession>
    <name>F9WII1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 796</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_19760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002599">
        <property type="protein sequence ID" value="CCD17129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19760"/>
    <dbReference type="OMA" id="REEVFAC"/>
    <dbReference type="OrthoDB" id="567473at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="633"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="686" mass="74937" checksum="76F7DBB167D258E1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIN9</accession>
    <name>F9WIN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002620">
        <property type="protein sequence ID" value="CCD17187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02290"/>
    <dbReference type="OrthoDB" id="1706189at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22460" checksum="5392A7309C49D1AB" modified="2011-10-19" version="1">MRGWGRCEKSSTRHGQKRSNGPIQENCWMLLYPRSRRSGETSRTPWEHHHDPTIAATKTRVVRKKRNHLRKHPGAPHRPHWKPLPVKRRIPRKGVCSSSPFPLADGSILIQPFGLPLPAVFLKAHPPSPTTISTIILIMVVHPVVSHSTGYFFVFPVFLLKLGKMRIKTLVLVLGVIRRSMEMSVRSGYYEHAFKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ8</accession>
    <name>F9WIQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 823</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002628">
        <property type="protein sequence ID" value="CCD17206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CGMACGQ"/>
    <dbReference type="OrthoDB" id="721127at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="418" mass="46234" checksum="FC49BDF178FF1C3D" modified="2011-10-19" version="1" fragment="single">MQPMERVEELLEQEREKISLIRMPLRTLKLSSLFCAKSITREIVAWVKSTVFIALVPLIILAVGISLFWIDAPAGRAFKFLDSDGDGYVSITEIKTYYANVLKKKLDTDSKTGSIFPRGSSRLDKAAFGSWWVEGYGDTIRQNAFFNQGAWREVEYILADAVWWLGLGILSSVGLGTGMHSGLLFLFPYIYRFCAAADSCGNTNFWVYPVNPVYGPRDRAFVCITPQQTVSSPSVLARVLLLLPACVIWGAGTAIGEIPPYILSYAAAQQGKRNSELEQTSKYDILNAMKVWMLDKIQRHGFIAVLLLAAWPNMAFDLCGMACGQFLMPFWTFFGATLIGKALCKVPMQVIFFVQLFSGDKVERIIHRIGDVVATVVVVPSWIAPGGVQGITNKTVEAIGRARQSIAQRARGEEGMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS4</accession>
    <name>F9WIS4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_20590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002630">
        <property type="protein sequence ID" value="CCD17222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20590"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="OrthoDB" id="1312756at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="222" mass="25607" checksum="1EE12B016372017C" modified="2011-10-19" version="1">MVCPSRKLVDRSSRKGFKKHRPEIIVVDLKDHVLGRAAAVVAKQLLLGKKITAVRCEQLTISGSEIRNKIKYLQFLRKRKLSNPKLGPFHHRSPSDVFIRTVRSMLPRYTKRGQRALRQLVAYEGVPVNVVRTGGRVVIPKAQRHYCYRKERRFTVLGNMCKHVGWKYSDVVKKLEAARVEKAGRYYKKMEGLRNSWKSARKEALKKMPQKSVAVLKKFGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB8</accession>
    <name>F9WJB8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 895</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002708">
        <property type="protein sequence ID" value="CCD17422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22430"/>
    <dbReference type="OrthoDB" id="1299789at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="24676" checksum="BB4D72698DA5DE0C" modified="2011-10-19" version="1">MSTATTYPDGKPILKHELVILDAGLATSLSRVDRNNFFSLFAAVACGDGALGADLMIDRLPPERRALQSKADRDKLRADMTEIFNIVSPGKSGGFRLRDISLGGMLQKVMSALRSNSTPLDGNFASLVLTVIVAEGLGKKLTPDFNLFAESAPYLVELLEDSELCFLAEKLRSLYGAKALLWNSLDFVKLERTPTYVEVVLRKISRTTDRAIQWFATRSATSNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG9</accession>
    <name>F9WJG9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002726">
        <property type="protein sequence ID" value="CCD17474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22920"/>
    <dbReference type="OrthoDB" id="1704465at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="23599" checksum="1B2210D457C4D33F" modified="2011-10-19" version="1">MNPVVAASLSTTFCGKNKITLKADNDQGWSSAGGDGGDQMTATWTNVTGECLQEGGKARDLKMALDDFLEELEKRPWGDIPERYQLGEGDSDEFPCSGNGKICVMYYNSTKHKHHMPWWTDLKNVLDAEEGKNKREEEPTKEESQKQKKSQRKENKQPQQAPRTAALKSATLDTQDGKQKNPENISAPLATIEEASGILITPPCTWFLGALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJL4</accession>
    <name>F9WJL4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 926</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002743">
        <property type="protein sequence ID" value="CCD17519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23340"/>
    <dbReference type="OrthoDB" id="2554at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="671" mass="73614" checksum="6D6A7BF3D034AB73" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJU5</accession>
    <name>F9WJU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 952</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_24100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002772">
        <property type="protein sequence ID" value="CCD17603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24100"/>
    <dbReference type="OMA" id="DNEEALW"/>
    <dbReference type="OrthoDB" id="132922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rav1p_C" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2056"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2238"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2060"/>
            <end position="2076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2461" mass="269259" checksum="7E3B39AAFBD715F0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK14</accession>
    <name>F9WK14_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_02690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02690"/>
    <dbReference type="OrthoDB" id="131230at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="PTHR11932"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="SSF75632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULLIN_2" evidence="3">
        <location>
            <begin position="542"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="947" mass="106927" checksum="706DBCBE9200A4E1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W355</accession>
    <name>F9W355_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1002</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000354">
        <property type="protein sequence ID" value="CCD11563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25360"/>
    <dbReference type="OrthoDB" id="1612139at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="742" mass="82080" checksum="9318F19487394197" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3E5</accession>
    <name>F9W3E5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000398">
        <property type="protein sequence ID" value="CCD11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14807" checksum="2B818BCBA5C151A4" modified="2011-10-19" version="1">MCIVMSRSGSFYTEGLYFACEQYSGEYIHKCLSKPAAVVIVISFLFIFSSVSLSLFLVAAAPSLTLLIFCLAQQLWVQFEVSPSFRCAAQNETGKEEGREERKKKWGLIVLLVSFSFLFRFDKETYLSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3T2</accession>
    <name>F9W3T2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_27490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000466">
        <property type="protein sequence ID" value="CCD11805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C26.A21"/>
    <dbReference type="OMA" id="GPDMDRI"/>
    <dbReference type="OrthoDB" id="392369at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 4" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="5">
        <location>
            <begin position="201"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="229"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29483" checksum="CA7CCE1AB7026DE9" modified="2011-10-19" version="1" fragment="single">MSVQPQSEEYIAILDAGSQYGKVIDRRVRELRVESRVMPLNTPTEVLRGDPSIKGVIISGGPSSIYDSNAPSYNKDLFELGKPLLGICYGMQLLTEAFGGEVGRADVREDGQDEITVDTTSPIFAGLSQRETVLLTHGDSIINPGTELKVMARSSANIIAAVQHQTRPLFGVQFHPEVELTKNGVQILRNFLELCGCAFAFTMEDREEKALRLIRERTAKGQKVLCLASGGVDSTVCAVLLLKAIGPERVVCVHIDHGFMRLNESELVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3W8</accession>
    <name>F9W3W8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000484">
        <property type="protein sequence ID" value="CCD11846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27860"/>
    <dbReference type="OrthoDB" id="1715565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19434" checksum="4CE4983F2C0A55A9" modified="2011-10-19" version="1">MVTASRTLVQRDVRHCGAQHLRQLLQHFTTRSHPKHLAVYSIYTTAVLPPRATALSRRKHSNHISACPFELHHIKNESSRYTPTDSTSITANRRLPSTSHIIVKVIYPSNSLYFFTTGHQRHKKASIKPTRDYKCRNILTKSTDPKKICYFEMLQYFEIPQYSKILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X7</accession>
    <name>F9W3X7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000491">
        <property type="protein sequence ID" value="CCD11855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27950"/>
    <dbReference type="OrthoDB" id="1722549at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19437" checksum="1415CFD45E318171" modified="2011-10-19" version="1">MIIYIYIYIHMRVYYTHVGVCCERLLLLCARVRTLTLVRANYSHPHSTPVWCALCVGGTARGGVLLLYRPQSLKRASEHARVQTRVPMSLSFSCVARVLRIVCAPRKGKKEVVWRRRRVLMPPDAYCVRTGSLFSLFFFSSSSFPCLPTCVGRVGEEVCVFGGRRCSGEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z8</accession>
    <name>F9W3Z8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28180"/>
    <dbReference type="OrthoDB" id="1722942at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17479" checksum="F678BF2A976E1B04" modified="2011-10-19" version="1">MMEEQDSQGLRENADDLFLFTESSCRNREQLLAQARKPRHGIFATAEDTHKKQREDDFFLGQETSTEIENLDFPTPEDLSAEASLHLPVVELLGGLSAQGAGNASPNLNDHTEIAWPMPSHLFTTQLTATGELQRHNSLQAFYQAHHAGRPTLHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K4</accession>
    <name>F9W4K4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000567">
        <property type="protein sequence ID" value="CCD12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30130"/>
    <dbReference type="OMA" id="ANEERMN"/>
    <dbReference type="OrthoDB" id="881655at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="799" mass="89641" checksum="037E73B1FC8FDAE2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Q5</accession>
    <name>F9W4Q5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_30630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000592">
        <property type="protein sequence ID" value="CCD12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30630"/>
    <dbReference type="OrthoDB" id="1677378at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389802" evidence="5">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38610" checksum="47072C5736B3D6CE" modified="2011-10-19" version="1">MMKIWLVFVIVMVVSVKAEEMDHNKDAHKALCRVLREVVGAYQSGSGSEVLRKALKKTIFGNETGGDLETLKGLPSDYEDVLRDVDSRSFACGQPRNHWEEYKSVYQPRWSGHSAPHDLVCLCTVGHKGWPLNGTTPEKEKEKLCGKTEDALGGNKEGWDSIEHGKGKAQIKATWENVTSDCFLGGGKGETLKDALKEFTGKLVPQPITGQENRKQLGEGKPDETYACTGSKTYGVCVMYYPTFTAHTWWVDLQKAIQEDEKIQEQKKRDEEKEKRREQEDAEKQDAQKTETLKSTLTTTNQTDQQHRNDTLHEKLRKLNLTSGTPIILPSSWLLRAVFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4W0</accession>
    <name>F9W4W0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000620">
        <property type="protein sequence ID" value="CCD12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31110"/>
    <dbReference type="OMA" id="CETALVE"/>
    <dbReference type="OrthoDB" id="1082069at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="38324" checksum="AE581C1AA562115C" modified="2011-10-19" version="1">MTLNLTALWNDRVVGTRAEISLVDDKIASILEKKKQLKEEIGRYNKIVEREKGEMLSYLEKVEAEAKRVEEETAKFESHRAQVKKEFNETLDNYENMRQVIKNIQRDEEALSKRYDLAKLFERESSEWADQERALRAEVETLEEELNNMRKAHMREIVQLEAEKTEAEDRLQQTRAQRQEELRQLTQAPLQNQRRSLSFAGNRVEQFEMTKIPKANRKEQQFIAMNASTGVPTRQLRSCLRNGNNNSNGAGANPNHNDMGSARDVTDSQRYNCNGGKPPQQPVSAPVSRAVSQSLVGGVEGSCDQPPVASGRACSHAEMKKVAGRKRGLLKDYTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4W5</accession>
    <name>F9W4W5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000623">
        <property type="protein sequence ID" value="CCD12212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31160"/>
    <dbReference type="OrthoDB" id="1707271at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="24200" checksum="61816E755F12F0C9" modified="2011-10-19" version="1">MARTHHDNATTVKGKMKDDTVSLIPLLSRSLQCPYCPMKCALKQYLTIHLQAKHGQPKKEAEHNLLKARCEESVAHLLECPSLRELRKKHGLETLRDREAFFSAQLSSFLKELFQLESPLSLPLDSSKLKPAQAVKRHRSPTVWDTVPTLAATKLIKVSNARAIRKCPREADSLSKAFCFKVPLGEARVGLHLSSTIPADFQSHRRSSESSVARAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W566</accession>
    <name>F9W566_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1281</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000665">
        <property type="protein sequence ID" value="CCD12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32070"/>
    <dbReference type="OrthoDB" id="1721111at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19151" checksum="D33B5BEE25F7F511" modified="2011-10-19" version="1">MIAGMRACSCEAIRDDAMQQAWNCVQSLAQRIHRNDEQQRSQYKPSWHSARELGFFRRSVMEYYPCRSSLKEPCDSRHQLRFHPKDSRCSDYVPVFYRVQCPCIVIETSWRPLFISLPLHALDTCISVSIIDAVGFKRTCFGYNLLAMQSRSSRTNTRSVSSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B5</accession>
    <name>F9W5B5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000689">
        <property type="protein sequence ID" value="CCD12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32490"/>
    <dbReference type="OrthoDB" id="1725463at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20129" checksum="2C511DA7EEA3DA51" modified="2011-10-19" version="1">MEAHGSHGPGEHGSDVGLSPWDVWYYRATTLCPPLTYTMTTPVPYVLAESMNDPDNLSLLQFLELTCQEVPLHLVRFSVGDFIRDPERCIPEDMLSKDILDKLDRMRCDLYGGLLEQCNLFAASHIETLEDWVQKGSSVNVGAIALSLLEEALWSAREEQVHAQPPSPASSSSLQDSFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5C9</accession>
    <name>F9W5C9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000698">
        <property type="protein sequence ID" value="CCD12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32630"/>
    <dbReference type="OMA" id="CTVNESS"/>
    <dbReference type="OrthoDB" id="360325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="635" mass="70123" checksum="B6A98630FF4F8736" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G9</accession>
    <name>F9W5G9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33010"/>
    <dbReference type="OMA" id="MYLTHAN"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="461" mass="53222" checksum="28EA240AE9122389" modified="2011-10-19" version="1">MYLTHANARYIGNRKRQSDGMQEADSRGLRDAIGPDAVRRLEKALSAARRVEENQVRVMPRSAEVINGLYDSVYNARWRCVISGKMYKNQPFGMKLLNAKTEVPCLWSRGDVDMTPELGQSYDIEEMLVRSEKVPVVAVLSSALGWPNRMHTPQQPLQALPAPQGESDDYTHLYIRKEMMRVWYIIEEELDRWLKPDECRMPQYHIAIGTAGIGKTRGLGPFLLYQLLHYSSEELCAIAYFSKGEVCILHRHKGDTPGMAVYYNVQDGVSEIERMATQCRKGYAIFDEYKEEIFPYSFPPCWGALVMSTPSPERFEHWVNRYQALPIYINCHDNLELKVLHALGRFSALRQEVPLTEEMIEGLKREWDELELRVRKVGPLIRYVLGSHFHSRWEDVEQVLQNSSRQYRRYSSGASRYSINWKEHAALFKTTRYMMEGAEVGICEPVSVIVHEKLNSVDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5K0</accession>
    <name>F9W5K0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000723">
        <property type="protein sequence ID" value="CCD12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14624" checksum="F2D6443E4C3FDB6F" modified="2011-10-19" version="1">MQKRTTTPYGDEQPEEVGSRAARETSEPTYFSPRENAGGGLPRDTPFDRQAVVVSPRTASLVSPRSSGGGRIYDGPYELSPCKRTGRGRVMGHNVMKSSIAFGDANIPMSPSSVRSPRSNHLNSSRVRDLLTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5N0</accession>
    <name>F9W5N0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1349</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000740">
        <property type="protein sequence ID" value="CCD12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33580"/>
    <dbReference type="OrthoDB" id="181450at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="494" mass="53958" checksum="0994D60A131C9599" modified="2011-10-19" version="1" fragment="single">MLNTCNVRIVSTPFGINGLECYDGNYSAANPHLLQNPHDEHVPATGAVVGGAGGVRALRKRENGSSPARPVIMASLHHKGKLVVWDVDTMDVVGCCDHSSSSVIECIITPTFIYVRVENEMGLEDKEASIFVWNTQTLKLYRRVIAHDGRVTSLAVSDQSDYRFATAGVDQMVHLWDLEKDHIGPVKKITLQSGGTVSLYHSGTVFVSCADHPIVVWNATTGAEIFRAKEGGGRITLLRWQHDPQRVRGHSDLPSDRSLIIAFSNGFIKEWKVHRSNSTDASLSLSLTWGHKVHRTSIDDICGDGEVVLSCSTVDGAFLLIPATGKMVMIYAQGTRAGLIDTSSKHAVVGGEDGSVNVFAYNNFCKEQGTPVAVSTFRPHIGSITGMFLQLQKNQRWDRLMCGSADGKLSFLDYSKSRSGSWIDKVRSQSVDYAPAVDGVIVPQRNGSIIIVDCKSLQPSAKQPPLKLSRPVIAVKWIEPHNRMLLALDSGELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X6</accession>
    <name>F9W5X6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000794">
        <property type="protein sequence ID" value="CCD12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16407" checksum="91B892B7FFFF6B5E" modified="2011-10-19" version="1">MYVTHGDARHIRNRKRQSDGMQEADSKGLRNAIGPDAVKRLEEALSAARRVEENRVRVMPRRAEVINGLYDYVSNARWICVITGKMYKNQPFGMKLVNAETEVPCLWSRGDVDMTPELGQSYDIEEMLLRSERVPVVAVLSSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W601</accession>
    <name>F9W601_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_34700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000805">
        <property type="protein sequence ID" value="CCD12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34700"/>
    <dbReference type="OMA" id="IWRTIQY"/>
    <dbReference type="OrthoDB" id="1407357at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="43601" checksum="6AB9BC8CF84810DE" modified="2011-10-19" version="1">MLVEKPAVLFRARKSRISVYMLPLMTLLALAMVGYTLYGIGNGDHTPEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDIDARRRLRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPTTRKRMGEGGSWGPEAQVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRVNLLWKSLELVYATGACYTLSKDAVQAVVSYKPLAALLSKPYSIWRTIQYKMMSVDDEDVMVGRVLARKIRFKALIVVNVGKCRLHGSGKTGLFPVVTQKSVVVYHIREEDYQRLWEWFDDNGKSHVPSQLHWFSETSATLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W679</accession>
    <name>F9W679_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1432</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000832">
        <property type="protein sequence ID" value="CCD12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35430"/>
    <dbReference type="OMA" id="HMIALYH"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="751"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="811"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="835"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="961"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1010" mass="119214" checksum="927035609780A975" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E5</accession>
    <name>F9W6E5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1451</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_36040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000853">
        <property type="protein sequence ID" value="CCD12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="T01.977"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36040"/>
    <dbReference type="OMA" id="SMYMHAY"/>
    <dbReference type="OrthoDB" id="1222564at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037555">
        <property type="entry name" value="Proteasome_alpha_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599:SF10">
        <property type="entry name" value="PTHR11599:SF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="25497" checksum="2B44342D6CAC88EA" modified="2011-10-19" version="1">MSGSGHDQSTDLFSADGRVFQVEYACKAVDNGSTAVAACCKDGVVIAVEKILTSRMLEAGSNDRIHAIDRQAGLCVCGVLPDGLAIVSRARSEAENSRETFSTPIMGSVLASRVGEFMHVYTTHFAYRPFGCSVIVASYADDGPQLYVSDPSGTVAGYYGIALGRGKTVAKTELERLNFSTLTCDEAVVALTDIIRKVHDESKDKIYEVEVAWVCDKSDRVFQHVPKEMIPAPSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6V0</accession>
    <name>F9W6V0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000939">
        <property type="protein sequence ID" value="CCD12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="15080" checksum="86F4AC7684D2E855" modified="2011-10-19" version="1" fragment="single">MPESPSSPSPEGMAQDNTPWSMEKDVVDVLLEGVLPAKEMNLYGFLMPVSPHLTEFHTHFTLRDFVRTPRRFIEEEDGCDLIWQNLPRLVWKFRSVFVPRLRHYGPPGWLEKLPKWKCWENSHPTGPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9W709</accession>
    <name>F9W709_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_37860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000960">
        <property type="protein sequence ID" value="CCD12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37860"/>
    <dbReference type="OMA" id="SEPNTWA"/>
    <dbReference type="OrthoDB" id="614710at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="2"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="134"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="396"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="457" mass="52435" checksum="AF7D007DFE3E1748" modified="2011-10-19" version="1">MVVDHSGYLQKSSGDFHKTTTTRYFEIRGSKLYYWARKPGKPSEEPINSIDLTDLRVTRDTVNNKSWTIQGERLRKSYTFTADNEEQRDIWIRKMTEVNPIHTEMLQTLDQSSEEDEAVTMYGGENCKVSLSDFEITATVGKGSFSRVYVAVEKATNKRYAIKEMKKEVIEREQMTDHIFAEKFILQKISHPFIVSLHYAFQTKRCLYLVMDFLAGGELFYHLGAVTTFDEWRAKFYCGEIALALGYLHAHDIIYRDLKPENAVLDKDGHVCLTDFGLAKMDVHDASNFTFCGTPEYLAPEFLLGKPHGKAVDWWSLGILLYEMLEGIPPFYSENLNVMYDKILCAELKFGVEGEEGNELPVISEEAQDLLRRLLDRDAATRLQDVEELKAHPFFRDIDWEKLVRREIDPPFHPSSNSLCNFDQEFTSLDPPAPLEDELEEGPTLCGFSFNGNAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W723</accession>
    <name>F9W723_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1552</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000966">
        <property type="protein sequence ID" value="CCD12982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38000"/>
    <dbReference type="OrthoDB" id="1664226at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="474" mass="51140" checksum="51DE8053FB6BAC06" modified="2011-10-19" version="1" fragment="single">MTLSEVISGFGKMTLSEVISGFVKMTLSEVISGFVKITLCEVISGFVKMTLSDVISGFVKITFSEVISGFVKITLSEVISGFVKMTLSEIILGFVKITLSEVISGFVKMTLSEVILGFVRMTLFEVISGYVKMTLSEVISGYVKMTLSEVISGFVKMTLSEVISGFVKMTLCEVISGTVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVRITLSEVLSGFVRITLFEVISGFVRITPSEVISGFGKMTLSEVISGFVKMTLSEVISGFVKITLCEVISGFVKITLFEVISGFVRITPSEVISGFGKMTLSAVISGFMKMTLSEVISGFMKITLCEVISGFVKITLSEVISGFVKITLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKITLSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W798</accession>
    <name>F9W798_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1588</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001005">
        <property type="protein sequence ID" value="CCD13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38790"/>
    <dbReference type="OrthoDB" id="1707090at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="21112" checksum="3F51210D1E44EA18" modified="2011-10-19" version="1">MCEALETVPIGHPRREIRSGIPSGKRNYCGGDVYINHDPVREGHWHEPLEHHLKKYYDNNNNNNNNNNIEITNTRMHTWIWIWMCICMYVCVCVEMHSTEGRNEVLGEEAPKRFMSSMEKENGSLQHRCGAKPQCHPIQHPNPHCHIRHAIKSMKDTAAAQGQGLEIVLQKKTVKHSLYTPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B7</accession>
    <name>F9W7B7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_04090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04090"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="79"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="45078" checksum="28B1AC515AA0E8A1" modified="2011-10-19" version="1">MCFSFLSIFLIIVGMWDTRMMVRAMLGVGFAMVLFMDDVRVYSYPDGTVFNDVEYKTLCEVFKASADLWNASRISEKIPNSALNGALTQALLGNIGNRHLSGIKESLPKYYTHHTLRHRGERCGGCKNTDKLYFPGSSITHDLMCLCTPGQDAEPFYGYYWFFYKENGFKLCGKGRAQMGVDLNHGWYVDKKKKGNNGLEKPWKTVVWGCFNSWKSNPGLESHNLTEKIVRLNATLQNFTSTLKKMGGHDKLGGFEEHNEADGSDERHIHVRYDNCKGPKKPWWKKLKETLDGKKPDDLLMSRPVDKPAGGAGETPDDGPVEEPSEEMEGEVGDMEVGGPTNTLATAAQDGNGTRMQEPTNSTEGSVIPLNATASGNSSHPRLEYLRSGSHINQPLLFPSAIFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7E5</accession>
    <name>F9W7E5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1595</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001013">
        <property type="protein sequence ID" value="CCD13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38960"/>
    <dbReference type="OrthoDB" id="1001347at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="433" mass="48113" checksum="928DD3C7C13BB5C8" modified="2011-10-19" version="1">MVGDGVCVNCGAYRSSLLPKNAPDEHDVGRISCGGCGLALYCSLSCANQYQSQHMQYECHLFKRLKEMRCALEASAEQNEVEGSQCEAPSNLIIDFFTMASHCITTLAGIKSRRPGYRVVLNELQGHAAEVSQNLSHMVRMVGELLRDEELPLEVARLIGIIRCNTIEVSNELSLGVGQALHATTITSYFNHSCSPNCAIQGEFIVTTRVIAAGEELTISYMPQLYWPVALRREELANTYYFHCSCERCRDNENDPFEAALVAVLRSECEETGGGGGAQDGNNAKAARVCGLENHLEAQRKYITDVQTLCNRIRSMDPSDITTTDRNELQRLLQKCCEELYPFHYLCHELRNALSFTFAALGDTKDCLKSCLDELLLWECIVPGAHPVKRLKLLNSMQCCEDLRGKGDELGNNNIGSMALIPLLEKLSRLYCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7G5</accession>
    <name>F9W7G5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_39130</name>
        <name evidence="7" type="ORF">TCIL3000_3_2840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575316">
        <property type="protein sequence ID" value="CCC89851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001030">
        <property type="protein sequence ID" value="CCD13131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39130"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_3_2840"/>
    <dbReference type="OMA" id="NLMMVEE"/>
    <dbReference type="OrthoDB" id="1037091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC89851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="29887" checksum="83A7ED29528C7579" modified="2011-10-19" version="1">MNCFICSKGDDARMAFGDPKRSRDVHDSRMERFNVEIRKNSALRNRALVSASLVGLSCAAGAIGALLGSGRTRYKGMWLDQCLGPIVIAHAISGGAAIAYTVCRSLAFERNVYNVELDRELWEIENHIVGEIQEMVAIYRAQGLSEDEAYSITRTFAKHPQVFANLMMVEELGYSRLEPPAWREAIVDAAIPAGVGYTAGWVLPLLPLITTGLGSARSEVLSVCTLAAGTVVVSVGQSEVFFGGYTSLRKTFESIAWNLAAVSAISGLMYVLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W5</accession>
    <name>F9W7W5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1664</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_40550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001091">
        <property type="protein sequence ID" value="CCD13287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40550"/>
    <dbReference type="OMA" id="SCEASKT"/>
    <dbReference type="OrthoDB" id="1072475at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="30"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="593" mass="66149" checksum="97C977CF6E9C75D0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W829</accession>
    <name>F9W829_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001125">
        <property type="protein sequence ID" value="CCD13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41130"/>
    <dbReference type="OMA" id="MNDTWEF"/>
    <dbReference type="OrthoDB" id="871936at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="640" mass="72372" checksum="7FC76A56DBB968F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W888</accession>
    <name>F9W888_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41690"/>
    <dbReference type="OrthoDB" id="1674443at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388800" evidence="5">
        <location>
            <begin position="27"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="40000" checksum="FFA83A2F79D48BD4" modified="2011-10-19" version="1">MKLLSWLRVSNLVLFMVLVSVGISLGIGHNEDAFSVLCDVLSHAERVLNKTGTNSGPLKEALYGKPGRVLTVQDGTVSLKGNCNSQTNRGQLCTYYNGGSYGCFAESLAGSLLCTCAPGNGGKDFCGLGILHLKSNWFGANLEGRKDLFQKVWDNLRKECSYGDESSSTHTAQLDAFKGALDRVRDMLRQGPPIARRMSFYLGEVNCAGPYGSKSCVTYLGQSKKHVHIPWLSKMQTTIEILRKQKHATEALPTLPSPSGTPPVPITNTRAELTDVESSETSTPTKTAEEKKTKETLTPGTPSPAEHPENPKGRSKRSTTAQGPVATSSSTEDTSITDEPEILDPTAAPFTLVEGADILPPLGLFMAASSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8N2</accession>
    <name>F9W8N2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001189">
        <property type="protein sequence ID" value="CCD13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43080"/>
    <dbReference type="OrthoDB" id="88428at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="559" mass="61691" checksum="76C479196B812FDD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R2</accession>
    <name>F9W8R2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1764</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001202">
        <property type="protein sequence ID" value="CCD13598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43370"/>
    <dbReference type="OrthoDB" id="1702159at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21855" checksum="CE897484010FD527" modified="2011-10-19" version="1" fragment="single">MTSNNQVGRHPGDQARNNYFRQYTENDSCIMDFQKAHPNYTSHFPHANIFSDENEVTNTFGLAGRHGPQNAWSPPPRKPVQVDDRSFSVMAEKDRNSGLRDTQKDFFHGANVPSNETREPEINFRTIGREMDHTVVRDYLGNDGVEQLRIPSLETKGEHEKIPIIQRTFGTRYPPGTSCHVMTLRKRQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Z3</accession>
    <name>F9W8Z3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_44160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001244">
        <property type="protein sequence ID" value="CCD13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44160"/>
    <dbReference type="OrthoDB" id="1670171at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394782" evidence="5">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="98"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="368" mass="41305" checksum="162EB90B0EC8F881" modified="2011-10-19" version="1">MKMMMFKTIKIMMVIGVLVEGVRETLDASEGSNKDDFELLCNVTRVTLGLWYTVTGAGYTSDDLIDKVDESTKIIDDIFFDVQDTKYSGLFWTLPDKFIKSRQKRSTICLANNGSNGMPSPSKSLVSAFLCLCTRMESNRKDFCGLEIDGKNIWTDYDNINVKDAFEEVWGSEFKSRIKKRCEGTDSDTVEVAQQNLSEILKIFKTSLITKQGIFGKDSTTCGTSNACANVTTTPTWLNKLEKVEQIAKHILTRLKTLEQESKIKLIPAAETQSTSKHTLESASLEPQVYNPQGKQHTTSPTSLTAPEKTHQQQSRKFPGEKPKQEHEPEMPVGKPHKQAEDFPPPENETSSSIINITKWPFLATLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W902</accession>
    <name>F9W902_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001248">
        <property type="protein sequence ID" value="CCD13691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44250"/>
    <dbReference type="OMA" id="LRTICPR"/>
    <dbReference type="OrthoDB" id="990509at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40454" checksum="1F921CAB5E0CDD91" modified="2011-10-19" version="1">MTEANKDVGAEILEKYFSDAYLFEQKNSFFREKVSPRDTGGLEVPPSITCTAFLRYANCPVDEKNTAAIFAAAATSALVEAVEGEGGVRCLRRRRFLDPKDDPALRSVVVWPLHRASTVEEVTAFFQEYGTVQSVAQLPRSPNDTQINTSFVVRFATEGEAIKCTKAVITLGKAPTPLAQHFLPSRIRAVLLEEHYAKVAERNRADGDAQLLHNVVQAQRTLAELQEPVIKRSLNRGVTLKVEGVPHGTSWATVKMKLGNLSITNPALKKSITLVKVEDNDATSPAAPHRAFVVCRNSSTANELLASYNLADGNFGQDLRTICPRLLPLTPEEEEYARRNFPEWCKRRVEAKQADNQKRFRSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W953</accession>
    <name>F9W953_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1818</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001262">
        <property type="protein sequence ID" value="CCD13743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44510"/>
    <dbReference type="OMA" id="RQNDDIP"/>
    <dbReference type="OrthoDB" id="1297202at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="306" mass="34274" checksum="FFA0C05833B3065E" modified="2011-10-19" version="1">MLDEAKSAYKKVIETIEVATIAPDPSVPDIFAWRLRPSEEAIIAYNRSLNPPEPWGIKLNCSSMFWGADKCINIGRKLILNNNVTSLDISLCDMQEEGAVVFFSCLERNRCLRHLNVDGNFIGDRGAVAASKCIKNLETFHASCNNIHDAGAIALASSLLDSAVIKTLNLRGNRITAFGVYKLISALEPVFDTLPPALQVSISAEQEKYEAITEKLVPTHRKQLSSTELSSSRFDVDESLLLMKECDQIDEKPEERLNTTLHTLWIRQNDDIPEELFKILEKILQKRVPQLQKGLSKKKIPKINTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W957</accession>
    <name>F9W957_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001268">
        <property type="protein sequence ID" value="CCD13747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1810611at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389983" evidence="2">
        <location>
            <begin position="22"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="16080" checksum="29B1BD1A79BE5251" modified="2011-10-19" version="1">MCGQRECAFLFSLCILRASEALPATLFLCMCVSHISDIYRMFVSFVVGEVHLPDGILPFCFSVFPAAASLLIASLFFLLVLLLLLLSVPAYLYQYAIVFFFLCSFFSFWMLCCFFFLPAFTFYVFVVFVVYCIFDVWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W961</accession>
    <name>F9W961_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1826</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_44580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001271">
        <property type="protein sequence ID" value="CCD13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44580"/>
    <dbReference type="OMA" id="EEHPKDM"/>
    <dbReference type="OrthoDB" id="1387147at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_S13/S15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_S13_N" evidence="6">
        <location>
            <begin position="60"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23830" checksum="223E7F0D3B0A1352" modified="2011-10-19" version="1">MTSLVGCCHAHAIATGCSVRLFVWQRVPWIVAFSGRVMLFLIFPLFTFHSFALGNRAAVMVRMHGDGHGKAASALPYRRTPPSWLKVASRDVIEAVCKLAKKGLSPSRVGMQLRDSMGVAQVKNVTGRKILRILKHRGMAPEIPEDLYCLIKRATEMRKHLERNTKDKDTKFRLILVESRIHRLARYYRRVKQLPPTWKYESGTASSMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9B5</accession>
    <name>F9W9B5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_45070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001291">
        <property type="protein sequence ID" value="CCD13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45070"/>
    <dbReference type="OrthoDB" id="1669409at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390030" evidence="5">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="40387" checksum="D30FB4359806AA44" modified="2011-10-19" version="1">MMGVRIWIFFLMVCGVLGAQESDIARKTDHNLEEYNALCNLMKISVQKWKELESRGNEGPLKKALGRTIFGDDRGGDLQNLKSETFQKVYKDVERNALSRLLWCGGPYDEDSRKRLTHEPRWPGHSVPHDLVCLCTVGPDGWPLNNNGKDKLCGLEGNALVATEKQGWGAGGPNSRGAKQIEATWKSITKTCLEGNASGNNLKDALGDFLRQLKKTPGNKYPERYQLGEGKSDDDYPCSGNEKICVMYHNSTEHKHPMPWWTELQGAIEKDDEIQAKKKSKEETSKQESAQKQRKTQNQEKPQLPQEPHTAPVKATKQDPTDIEQENTENLSTPIATLEEASSTLIITPCIWFLGVLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9D9</accession>
    <name>F9W9D9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001299">
        <property type="protein sequence ID" value="CCD13839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04910"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394623" evidence="5">
        <location>
            <begin position="23"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="97"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="260"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="452" mass="51181" checksum="B894A16845AA4830" modified="2011-10-19" version="1">MRKAMCILEFLFFMIFLGGASSTTGNELYNQEEFKHLCKILRVAEGEPPEIPDELGKFLETRKILEKLLHATKTSMTTYQKVIQLKSSDKEDAEFVSYTVKRRIANEKIKHAMEKVKDVYNRMEEELIQAKKERTLARNNLVHAIYGVQVGELPEKKDIEEVLKNVSRSSISNKDGGLKKVKYNTEAPTNPTCGKTGDNGPGLTLINDFYCLCVGKDNAKAVCDKAIAGPCCCCCKDCSKDCKCDKPCNCNNNCNCKDSCKNCKLHNKWLSLFDTSNNTILGLENGWPLIREVCNETSTEQINTTAESIQEVLDDFNKLLGNSSKKNEITPQNNPNVESRRLFVLGYTKKMDGQGCNGNGGDEGVCVNYWSVSNLGIGIVWQNYMLEAQKHLQEMDKHIKKALRLSTMIQKLKESAEESYWNSGHSSLLWSKDYGFKGQTFFNFFIFFVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9G5</accession>
    <name>F9W9G5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001306">
        <property type="protein sequence ID" value="CCD13865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45560"/>
    <dbReference type="OMA" id="FKQHGKR"/>
    <dbReference type="OrthoDB" id="987411at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="PTHR12233"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="40115" checksum="B0D1302DAB661594" modified="2011-10-19" version="1">MLERKLLQEKERSSGLFSRIFRKMDGCDVQIVLDGKGEADMVRVDDPVDNTCELLYVYSGDEPVNGKVMLTPKGSYRHNGVDVQLLASITTRSAGDNKVEFISQTKHFEPDTLQGPTPLQFSFTAPKEYESFRGISLLVTYHLCVVIHRPIKNVTERMELWVTRVDTKLSESQPDASRHRSYFRETVFGPLSTTMDVGVADLLHIEFKYDKKYFHLQERVLGKVTFKVTHMDICHGEVAVTRTETVMPPLVESEVVHSETLQKFEIMDGTPIVGEVVPIRLYLKAIPNLTPTYMNIRECASVQYSLNLVLITSEGKRFFKHQKIELYRRTGQESLTTTAWRQDGADEKSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K0</accession>
    <name>F9W9K0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45920"/>
    <dbReference type="OMA" id="HTHRNAC"/>
    <dbReference type="OrthoDB" id="261349at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="783" mass="87951" checksum="19BD891E0478017C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M8</accession>
    <name>F9W9M8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001331">
        <property type="protein sequence ID" value="CCD13932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46180"/>
    <dbReference type="OrthoDB" id="1664376at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="464" mass="53400" checksum="F30936863364D5E6" modified="2011-10-19" version="1">MSARKREQHQDPQGQIVPVQQVNPVVHEPHTQGDIQLEQHLFSVPEMPEQQPVPVTQHPCSWKKPGYNYMHDGLAPTLPYHSEDHKLRLSQAKQLDAMNNSSRFTQLCIEYPDATETNRSSRDGFPPRFLRLTRNAETQRPLQINPVPIGTVVHQPNGMPQIITDPSKSKRLGIKVLEGEIANRRIMNLHNARAQLRTFQSVQTDIEFTDEMQVALRTFNGTLYVLERYGPAITMEGILKAHGANWEKHLEWLGIKTPTETIGHEAQGRIDQYRSAYQAACFWADHHERTIYGLAGPLGETIEPFSFEDYDNMFSVFVTYVLTIIGKIHAGRVIDPKEIRNRYAEGIKDELQQTIDEHINSFVSRKYSRTASSRRPMIPKGTRVAGKGYYIGSGRRHRTYSTESRKGRNIGQQYRKYQKQDSYKSLRRTQRARSKSARRRAATPKPKNAKDRVRFAETPPRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P5</accession>
    <name>F9W9P5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1883</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001334">
        <property type="protein sequence ID" value="CCD13949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46340"/>
    <dbReference type="OrthoDB" id="1722545at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18680" checksum="EB263A4F9D00985F" modified="2011-10-19" version="1">MGRLGKRFSQEPSPLGGLLKNFFHSLEKRFLSLVVVVLTVQVTGFMQDTTEKLPRFLLRVLGLEHGPRHILDRQSLKIPLARTLLPENDSPSRLVERVGASMVFHKAVQRLQLAQEREEKFVHGRLRIQGIAQGRGPPPHGQCLQVPSALVLKDDLSHGLSEGCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9S9</accession>
    <name>F9W9S9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001342">
        <property type="protein sequence ID" value="CCD13984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390042" evidence="1">
        <location>
            <begin position="21"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14063" checksum="6F4890B227D91FFF" modified="2011-10-19" version="1">MPSVFFLGTLLLFIATESLYRKLSNVLGMRHSLLSDGLKIACTLPSSTLRPGCLVRHTEADPDPACFTKQKTGRGKDSPQKIVKCYNVQPSLNQVRTKITLPLKSERYFYVGRWGVGNNSSSASEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U8</accession>
    <name>F9W9U8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001351">
        <property type="protein sequence ID" value="CCD14003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="15576" checksum="21ACE07ED4513A55" modified="2011-10-19" version="1">MKGGAGGAAHLTADGVTESDQTAVSFSHPAVGRVSVPCSVGCPKRSDTGNAGFVVDKPQKPKLGATLGKRQVHAEHQKANRLKQMGETSCRAVAPLSEAALRGIKRRVAEYLPPCFTCARSFNGMRRSNTEVEQHLAGTTDATFREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Y2</accession>
    <name>F9W9Y2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001364">
        <property type="protein sequence ID" value="CCD14037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="457532at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044569">
        <property type="entry name" value="PDIA6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PTHR45815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="41"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="366" mass="40831" checksum="DAF8168132FE9512" modified="2011-10-19" version="1" fragment="single">MSLLRSYIHAVRGLQQFFAAAAVLLIIGTALVCAQAAGEVVDLGDKGKESDLLLLRDDTFDSYVFPKGSHGRRREPWLIFFFAPWCGHCKNTLPKFADARLVLGKKALPHAKFATVNAVSSPELTLRFRVKSYPTLIYTLGKGENWHVFRGAYTVEALARFAIRLHYAALVGSFADVTSHPTQFLKVQQSDWGKRVPMYVYLPPTSSRSGGAEQQRARPMQESQRVQSEEQIGEQRNPNSTVEHRDGDDKGRRRLVGLREARWNIALDAAASMESVRFGVIFGDDVPPNWERNGVRSYVAVLEAVQRCKSSGPDGAVLVVDSDAYKRPQCYEGPWFEESAEPTRKGDTAEDNVAPLLHPSFALFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA34</accession>
    <name>F9WA34_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_07830</name>
        <name evidence="8" type="ORF">TCIL3000_0_47570</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001380">
        <property type="protein sequence ID" value="CCD14090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002050">
        <property type="protein sequence ID" value="CCD15770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47570"/>
    <dbReference type="OMA" id="LDCHFHD"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="42505" checksum="8138ECF157CAAE72" modified="2011-10-19" version="1">MYLVHDTLMEPLRWAMLLVSIASCYIAITLFLIGPSGVVTRAPPAELTRNYPGWMREALAFTPAAAIRKWQHIDYLLVLGIPSVDMLERQRRRNLQRTTCWQYDGVARRANGFTGAMLPLYVLARHPSNGYAYTDAMRREVLKWSDMIALPMYEGKPSTNKKVGGGGKWGTEAEIGMSRKTFYWFDFALRMFPNASYFAKGDDDMFLRVPQYLADLRSLPRRGLYWGTMGHFAVDGYGFTYAFGALYTLGRDVAERFVSYLPLKSVIDLPYSEKEAHKFKALYLYAEDAMVGITLKRAGYSSELFHVNEKKCSFHDIHAGPLVGPVSSSSVMVHHVKEEDYGALMKRFNDGKVVAPRHFVYSTKMVVSRSLKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH8</accession>
    <name>F9WAH8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1977</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001438">
        <property type="protein sequence ID" value="CCD14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48860"/>
    <dbReference type="OrthoDB" id="1711447at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="19125" checksum="83A7E8082007BECC" modified="2011-10-19" version="1">MERDVADVLLEGVTSADRINLYWFLRPVRNDLTVELARFTLGDFVRNPRHCIPEVNVCDAVWQYLPYLLWKFRLSAKPLVRHFGPTQTWKKWQWDSWKIYLNMDDTPLEAIDQEIWRRCRRPPVFQYGPYQGVVFLGATLSFIQVPLPTAGYLIHMPLSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAK1</accession>
    <name>F9WAK1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ANSSHWK"/>
    <dbReference type="OrthoDB" id="777540at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43884" checksum="A82D7DA398498A64" modified="2011-10-19" version="1" fragment="single">MKRSAKGADALNEAVIPGIRMAAKRTIPKGKGVAPPFWTPELTKLDKMVQECKNERKRCTDPRWTRKVLVDTAIGRWKENVSKLSTTDSASWNLVKSMYAPRPLTSPVLVVDGHPLTKRQQAQALAKMYMSRSTKAPHAPEMRIPCTRSSTFRPITEAELDVALRELSSGTAPGDDEIHCEELKELGRVAKKCVLRLFNCSLRTGQVPAKWKHGIIVPLLKPNKPASSMASFRPVTLTSTLCKLMERIVARRVRDCIEDKLQPQQAGFRPARSTLDTLMQVTSAVRRRRDGEKTAAVFIDYARAFDSVDHNCIVKALMSFGVEEHLVAWIADFLQGRTAQVRVNNTLSEDISLTCGVPQGSVLGPLLFIVTVDSLSKRLNCIPGLQHGFFADDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAR3</accession>
    <name>F9WAR3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2007</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_49670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001471">
        <property type="protein sequence ID" value="CCD14334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49670"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="202"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="751"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="686"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="863" mass="97596" checksum="BF5D072854FDEE16" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV5</accession>
    <name>F9WAV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001487">
        <property type="protein sequence ID" value="CCD14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49960"/>
    <dbReference type="OrthoDB" id="1679376at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394644" evidence="5">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="43"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="318" mass="35041" checksum="B86872B85EAC0B13" modified="2011-10-19" version="1" fragment="single">MMKCLLFLVVAILGMANATEDQEKNHNGPQHSALCGVLGSAVKKLEEVRTREPTDPLRKALATTIFGNGAEEKIETLKTGTPAVYRDVEIRDADRGFWCGEPRDEDGESGQMQPRWSGHSSPHDMVCLCTMGEKGWPLNGSSGAQEKLCGKTADKLGGSGDGWSSSGSHQGGKQIQATWETVIVPCLNGEEGGDLKQALNEFLGNLQHKPDGYINPNRYILGENNLTETNADACTGSEKYGVCVAYFNATTKRYPMPWWTDLQNALLEEEKFQEEKRREEEKQRQKEDAENKDSAQEAALKSGTQTTNQTDQSHKDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB06</accession>
    <name>F9WB06_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2044</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_50480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001513">
        <property type="protein sequence ID" value="CCD14433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50480"/>
    <dbReference type="OrthoDB" id="1743407at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394820" evidence="2">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="18917" checksum="FCA817B9390015EF" modified="2011-10-19" version="1">MRARTSALLISALSSFSALLPHVPASFAKDAPLLTGGLLQWGPHVACLVVPFLDLPHLTHPIPAAHTLQFPLEHGKPHVPATLSSPPLLSAAASSAASSAAMHGGSSGSVAPPCLPIRCRSLLAHALSSHLHTRHANSPLAFGPRPLEDRGCPSPPPPPQLTFLSVLGVSLATAIPTTGTPQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB81</accession>
    <name>F9WB81_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001544">
        <property type="protein sequence ID" value="CCD14512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51200"/>
    <dbReference type="OrthoDB" id="1709730at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="23692" checksum="A0F21FCB9A45DDC6" modified="2011-10-19" version="1">MTVKTPATPAPKTITLRGATAARHIGRRLKTVSNCVWKRLVEYEQKFDDVNKVRDIVLNKVFIQGGHNLNCGKESSLLPYTQEHLVALQQTMEQNREASIMASGSAGISACGLDEFMSVSKQNTRETGDRNFPATCYKGNDNNDTKDATDTQYGDGVEGLGKCVDAQFSLRNTQGGRIGNNCTLANMKNDGGYVDKKPFTTISSGEWNFWIQRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBJ1</accession>
    <name>F9WBJ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001586">
        <property type="protein sequence ID" value="CCD14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52280"/>
    <dbReference type="OrthoDB" id="1001742at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16862" checksum="E9441A8774B1F6BF" modified="2011-10-19" version="1" fragment="single">MSCNASTSLWASEEEVTGWAFVTNQLALDNARRAVTEVEEPAARANIVAKWLDGLNALINAHAASVSFSLRRAVTTEVRRENVRNTEKVDKLRLHMLEISCQKIVKSSQEELDLLRVEREAEERRLELTRKQIQRAVGLFREQFGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBN1</accession>
    <name>F9WBN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2122</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001600">
        <property type="protein sequence ID" value="CCD14664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52600"/>
    <dbReference type="OMA" id="TSCAREY"/>
    <dbReference type="OrthoDB" id="964605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="26584" checksum="769FFD07F11C89F1" modified="2011-10-19" version="1">MGLIVGGCHDMHAGWKGYNFKYANHTTNVAGRVLTDRLMSYLRSKGYALSTLNDRRLVEDIKHKLCYVAMDVKDEVKKLHNKLQLEYYGLPDDQRVYLHESQFMVPELLFNPRQKGTCLVDADHNEEGSCVPAGGWADIVSKVVQTSPHFTQRLLYKNIILGGGSTMLPGTEDRLQQDVTTLLTGTEFEASCVAFQDRDLAAWIGGSVVASMPTFPKMCLSRKDYLEKGAAIIHQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP0</accession>
    <name>F9WBP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001603">
        <property type="protein sequence ID" value="CCD14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52690"/>
    <dbReference type="OMA" id="ADAIDIM"/>
    <dbReference type="OrthoDB" id="123887at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="861" mass="94444" checksum="1CF318B2E2E4D0A5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBV1</accession>
    <name>F9WBV1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COPIIcoated_ERV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_53300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001627">
        <property type="protein sequence ID" value="CCD14737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ESEDIXH"/>
    <dbReference type="OrthoDB" id="1318747at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="PTHR10984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="COPIIcoated_ERV" evidence="2">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15926" checksum="B41F64F0ECC74A20" modified="2011-10-19" version="1">MVNTRGVENPSEDLIGRFAYFVKVVPTLYQVRTLMSLGRVVESNQYSVTHHFTASWDAADQNNQTNRDANPRVVPGVFVSYDISPIRVSVKRTHPYPSVVHLVLQLCAVGGGVYTVMGLIDSMFFHSIRRVQEKINRGKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ0</accession>
    <name>F9WBZ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_53640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53640"/>
    <dbReference type="OMA" id="RDNSHGI"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388954" evidence="2">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="14855" checksum="57B0316E582A577E" modified="2011-10-19" version="1">MTPRHLCFLTVLLFGAALFSAEGSAAAAPAPAVRRNVEVPLAKAEEPGENGTEPGENGTEPGENGTEPGENGTEPGENGTEPGENGTEPGENGTEPGENGTEPGENGTEPGENGTEPGENGTEPAAGASGFMSVVMPMAFVAVGMVATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ4</accession>
    <name>F9WBZ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53680"/>
    <dbReference type="OrthoDB" id="888660at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="36476" checksum="C881CDBFE0A8E65C" modified="2011-10-19" version="1">MNTGANSHASQSGESLQVGLEFTRIPEALGPEVGSAAGTTSVAVNTSVLQPQHLQIITSHAGREIHIDDGGDGGAEAGAVGGASWVVEALPSQYAEPCLSTVGDTAGSLSGIEPTATLPPGVLPLVQLLPAMSSNPATMNSVAGIPAMETPNSAIWGIGPPGFTTMPTRTQPTPGNVVEAPLRFKMPPSPVPLRELLANADPMPSPERLNRYRQIMLRWYQRIEAVGENGRMQTRSRCPEPPANIVDLRVSCDIEALLNWSSVCCRWWDETSRKRSRRGHRSGRGAWAGGRDGTLARGQVSAQTQAHSERQDQTQAQSQSRSGLASADTWCPNWVHDLLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC83</accession>
    <name>F9WC83_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_54490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001681">
        <property type="protein sequence ID" value="CCD14875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54490"/>
    <dbReference type="OrthoDB" id="1673870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="39405" checksum="49B47D09B2B6753A" modified="2011-10-19" version="1">MVIGIWADEVEEIVLDDNDFELLCNVSKSMTGLLYTVAEVPQVSNEISEIERELSDKIDEIFFGLEQSGVYSGYSFLPKKFKNTHPNRKEVCGSNKKSKEMPSASESLASAIFCLCMGTTGRDEDLCKTPAQSRRSWPYGTKIRMVQNEFETVWDNVVINQCIGHGGASLEKEKQNLADNVTKIKEKLEMTEKLATKKTSCDESNACAKVTKNPTWLENLREIENITNRTLVLLEEQKKRLESIRPKPETPLPSDSVSEVTSETEPDPLNAQVKAPVPEENRRQEQRKAPEAKQKLEPKVEQQTEKTPMEVYQTKAKKEEDSIQAPETNKTSGPFMTSPMIFHLATLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC87</accession>
    <name>F9WC87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_54530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001684">
        <property type="protein sequence ID" value="CCD14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54530"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="OrthoDB" id="592406at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="SSF55481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03676">
        <property type="entry name" value="aRF1/eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="5">
        <location>
            <begin position="6"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="452" mass="50723" checksum="7118A6B04E3F1470" modified="2011-10-19" version="1">MTDHELSESEKAIERYKVKKLIQMLESARGMGTSVISIYMTPKEQISGMVTKLNNEYGTASNIKSHTNKLSVQSAITASLGRLKQYNRLPPNGLLLYCGTVLTAENKEKKLTLDIEPFKPVSRSLYLCDNKFHTEELHRMLESDEKFGFIVVDGSGTTYATLCGSVKEKLGSFTVELPKKHGRGGQSKNRFARIRMERRHNYLRKVAEGATQLFLSNDRPNIVGLVLAGSAEFKEVLYQSDLFDPRLKAIVVKVVDVAHPGDVGLNQAIDLAADSLSGVKLVQEKKLLQGFFDQIACDTQLYCFGVQDTLKCLEAGAVETLIVYEDLNIKRYTIVKNRGADDEETVVHVMSEGDAKKANIHAQESGKTRNEIEEEDFVDWLATNYRKFGCSLELVTNRSQEGTQFVRGFGGIGGVLRYKLDIIALRDVEKKEEDEERIAANNEDFDFDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCC2</accession>
    <name>F9WCC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54840"/>
    <dbReference type="OMA" id="CVAINGP"/>
    <dbReference type="OrthoDB" id="1129417at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="1">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="255" mass="27648" checksum="2D3AB48E104AB63C" modified="2011-10-19" version="1">MTTVTRRDGRGPCEMRGKELRASDLSQFDGSVWYSQGLTAVCVAINGPTAARQENYRRCTLNVRVSRMSRIPPAGGTDRLAVMEKRERQQRADGEMEQFLAGLAEAVVQLDRFPRCVLEVNVMVLMDDGALLAVAANAMMCALLDAGVPCHSTVAAVSLLLCVPAKTEDEETPVLLLDPTAAEESTDEVRSYAAATFVLMNSSDGVVASDVHMRPRSSAYSRPVTPKELNAMIALAAKATETIFTFFRNCGVPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG9</accession>
    <name>F9WCG9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 2232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_55300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001723">
        <property type="protein sequence ID" value="CCD14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55300"/>
    <dbReference type="OMA" id="RDCETAG"/>
    <dbReference type="OrthoDB" id="674800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48746" checksum="177D02CF8AAE1032" modified="2011-10-19" version="1">MALGFSSSAEVYVYVTCLLLGVSILLPLNTRYSAPMFMVNYYKYVTGDENAEPNSVLFWANILTFYNVISLVTQSLIGPTVLTPTVRRLSLSLRFALSITFMMMEVFVILMLPVIKVSQTVAIVFFVIVTILGGMGKCYLEATSYTLAASMPSKFMSTIMFGISFCGMLTSTMQCIIKVSMENTYESQLTQSYIYFSLALLIMAVALVMVLTLRYNSYAQEHVAEFRVLKQKQEDEGVEPQPVADVPTEVKEPTGVEDQCEVDNSGEGGMTTAEQLAATPIMPVVRIIRMMLISCFLGFFLTIFIFPSLVIPIDRVDDWFSTIAALIFNIGNSIGAFSTSFETFRYPRRVVLYGIIVRFLLIIPFMLSIYKYIPGHVGPYIFSFILGLTHQVPVLSMVYGPITPGLNDGQKLMAGQLMGIALLAGATAASVSAMIVVIFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS9</accession>
    <name>F9WCS9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2262</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001756">
        <property type="protein sequence ID" value="CCD15077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56400"/>
    <dbReference type="OrthoDB" id="1728303at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16467" checksum="7EE4107ED04FA18D" modified="2011-10-19" version="1" fragment="single">MRHISWRVLSPKEAGGRKARAPRRVGAPSQIPPDMRSNTAHGSFEKHAHVSSEIHTLPPTDTHGGDLPLASFTPAVAAHNACQPAFPKTSARVSRVRSSAAAFSPNTITGWQALTSRECGRHCPEACSSGNTSPAISQSPRRLARRHGGSTHGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCX6</accession>
    <name>F9WCX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001784">
        <property type="protein sequence ID" value="CCD15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56840"/>
    <dbReference type="OrthoDB" id="1701336at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="21860" checksum="F3925C055379D397" modified="2011-10-19" version="1">MSPVRQSYFRPIHTSPSISLCPTLTAAGQAVAADGRFCNAPRQMVRGSHISLAGLKLTHIIEHSARLSKAFPFTTSRTFSGSHIYTYAAIRMPHAHQWMRPQGLTHLLPGDTIGSQHITCHSHLRDSSGHIKHMSDTMWSRTHSQVPHSSTASLSTPGSNISFPLPSARQGKFTAYQHSTARPRGKAMESALSKPFLAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD22</accession>
    <name>F9WD22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_57210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001808">
        <property type="protein sequence ID" value="CCD15170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57210"/>
    <dbReference type="OrthoDB" id="161121at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="609" mass="67838" checksum="4DA2DD949827BE86" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD64</accession>
    <name>F9WD64_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2325</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001826">
        <property type="protein sequence ID" value="CCD15215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57590"/>
    <dbReference type="OMA" id="TEGMHAP"/>
    <dbReference type="OrthoDB" id="1576281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39742" checksum="1DC81760F17A7F79" modified="2011-10-19" version="1" fragment="single">MDTSPLNPYLLFSNADEFSTSGKVAYALRHPADRLSTEGMHAPRELREKSLISSVKDLERVMLPSKSHVQMVDTVGSQGVRDNFSTLPEGSKKKLVPPHVAAGGSAPWENESIKSDSENWNHARSSTDAWNRPVLSLYQQYTLLIAIDFGISSFCISEGGVVLVDNVPRAIEALLNVINTCLATRRSEMTQIKRWLQTHLEESEWEHILHRVWSPAVKVTIILINVPALDMTPASSPAHSAEFPTKGATFSEHPGDLHLFPETTRTFLGLKGAVSFGGAEDTSWIPLVTQCDAEEILHDTSFVRKLGKVLSDYEEVCRSQLHGGWPDVSLLTSIEHLVSLVPERSSCCTSVVFLNNASEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDM8</accession>
    <name>F9WDM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2383</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001890">
        <property type="protein sequence ID" value="CCD15382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59080"/>
    <dbReference type="OrthoDB" id="1732658at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16875" checksum="85C9C3B23ED14128" modified="2011-10-19" version="1">MKKKASLVQPATSSWCQGPVFFIGEEAKCQPRFRCYRLRSWFPAKGPRRCKLKSNRSPLVRVVLVTTLSNVMSTQPCHLTDSVPCKKHCVRSCSCVVMWNQIPGTLTTLELNVQSLTKTKLSSLLSGGSDIIIVQEAWKSAKEISSLKTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDX8</accession>
    <name>F9WDX8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001928">
        <property type="protein sequence ID" value="CCD15483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1686745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="29250" checksum="AA1D9A179E417AA3" modified="2011-10-19" version="1">MQQQLEHLQGIIAQQAAQLEEYVRTDATLRQQLTGQGVGAHTEEGERHHGKQDTGNVKRMDEYAWKGFPPHAPRPSSGGVGIRGIKELRGNSWMSGVRPEYKYSYISECDGVSLEDRNPEQLIAAYQYMSPTAATPGPAYTEAWKNFVSWALGLRSEGISEGHLQLGRQLYNQLRTIQTVKDHPGVKIEDIRESVEYPHRKDDVFIQAALKAKRHQTAIPPGRAQCFTCGRVVHYSSSCRVFKKKPESHPTNGFRPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE03</accession>
    <name>F9WE03_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001935">
        <property type="protein sequence ID" value="CCD15508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60140"/>
    <dbReference type="OrthoDB" id="840774at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="481" mass="52358" checksum="641ADCB7B60A4C85" modified="2011-10-19" version="1">MEIDDHQLLVPGRFKYKSVSQDPARAEADSLDDENEYITAGEDSGNWCGAVMDTCIDALRSSFKLLISFVRRSVAAEHHGDDFPSTEAGAKTGIPGFNTANERDLFSSPRTQHGGFSKQYSAVPSSAPDDQQNGVVTGNAVASGPPPITTSGFSDFTAHVESPTAGEFPSEFNTTVVGSCGFKTSTTSIMHALEDEREAIHTLEQLCTVLERISEYSPVRVEAELDGRGSGDTDSSVHVPLCHICLQVFGPIRLTPHSAVLSLLEDILLEDCVPSSLQISSIHFADVAFSSEAATALQSTTQTDGDADLDVLPAFGFPTTRRGGLDTGDNKELRKECIERFCVFAKNILECYNHTTSVRLTRCSFTPGDLGRGLKLPLLHLRCLYFEKCPLSAAHIDALLRMAKAASRQSSRAQAFQWLEELQLSGSLTEESVSAVLSYFYDELLECEVSLVSLRVPSLWLRVARSHPLLERQPMLVVSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEB3</accession>
    <name>F9WEB3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_61030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001968">
        <property type="protein sequence ID" value="CCD15620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61030"/>
    <dbReference type="OrthoDB" id="1710999at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19600" checksum="B2EE4B4387BB4063" modified="2011-10-19" version="1">MLNGLFLWREPRRDTLVGSPFPWDLIYFNCDNSPAVCLCFTWRFFLTKFAKDVRVLAPHFAYVENHLDTLYSLPRARIDSVFLLSLFFRAALVDTASFRMWRLPVTCSLNRVATIQYGGLAIISDHTLPHHPSSRGVSLYLPIDMFSNLKYGTFWLKEHLYPFEEASLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEB8</accession>
    <name>F9WEB8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2454</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_61080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001969">
        <property type="protein sequence ID" value="CCD15625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61080"/>
    <dbReference type="OrthoDB" id="1735425at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15162" checksum="D668EA132B061A94" modified="2011-10-19" version="1" fragment="single">MMENKIFRFSRTNSAAVSVNFPVVDGFFLVDAVGGGVSFTEGAAVPTRTVVMIQVTKASHHHTTVSKVESLRTRIAKSFTNWTEMESRLSYEIIYVQHAESVALTGRQRCDRGGVADDTGNERFGTTSISSVETGGPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEE1</accession>
    <name>F9WEE1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 254</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_06660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001998">
        <property type="protein sequence ID" value="CCD15648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06660"/>
    <dbReference type="OMA" id="AIIMGHI"/>
    <dbReference type="OrthoDB" id="1116351at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394712" evidence="2">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="3">
        <location>
            <begin position="23"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="450" mass="50124" checksum="27AF4E5671437998" modified="2011-10-19" version="1">MLNRVLSVMAFVAVSSYECCGLRLGLVSDTHYDPGYGTSRAYRNCGDRSAKYGKAGCDSPAALVTSLERDMRGQSIDTVILAGDIQRHKFGEGGFTIDETFGFVLRSAAQVPQSSVFVTGANVTVSLGNNDMVPNYYFDIEKQNEYLIQEYKTMRASGTLDESEKGTFLKCGYYLRKVSSRLRIIVLNTILWCHCSKAPIPDSVADPCGQMNFLRKSLEEASLSNARVIILSHVPPYVDLWKVLKRGSFASAQEDMYWKPVFQERYHDIVSEYNAIVVAQLFGHTHKFFYQVVKSKMVSFVIPALTPLYANVPSYLIADVDHITMKINSMRQRFIINGEWRDGDSLESLLGHPNNPRALSLSASRLKSDDALWKNWSRLHSGGILVKGLFPKGECDAWCRRVVSCSMTNSAWKDIKFCVHGETGTSAAGIHFAVALLGVPVFPLLLLTCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEL4</accession>
    <name>F9WEL4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 285</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002032">
        <property type="protein sequence ID" value="CCD15725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07370"/>
    <dbReference type="OrthoDB" id="973872at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="DUF4217"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4217" evidence="2">
        <location>
            <begin position="84"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="26593" checksum="1412A4E63AD0FDAE" modified="2011-10-19" version="1">MLFLMPQEVGYASYISNFMNTEGSVESAGGEGRRKVASVMEEKKYESFLFYLTKLDPKSNHMWIQSTATLERAICRLVMKRHTTLENSGDEALGRNDDITRLALFAYQSYIRAYAGHSRELKRLFFCSDLLHLGHVAQSFGIDKRPSEVRSQLQGFIKEDRKLSRRPLSDAAGEKDEKPRKVPKLEMSHSDRYRSTVVQKQRKVTKDWYEKKRAETPAQRHQQFTEFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF11</accession>
    <name>F9WF11_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08710"/>
    <dbReference type="OrthoDB" id="1741495at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17464" checksum="7A0F067993FDCEF8" modified="2011-10-19" version="1">MSTLLLFIRPQHVYSGLSMLIGPLCLILVTSCLLSFFLHLGYMGFLSGFFDGLLLLFYLFSPLLRAIVMCLLRADLCKYPRCCRSSHDVLTGCWWSAYHLSPLHPTSLRLSSFANHLLSPNKLTSILLQFSAVVTHTSRDVQADQIEAKQRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF69</accession>
    <name>F9WF69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14687" checksum="A2854DD16B5987EE" modified="2011-10-19" version="1">MALTPQLTATLHHWRQHLLQGRAAKVSWHHASLPATNTAHAILSCVLHPNAHRNKSWSSCTACASTPQQIASRVGNMRRLLPTVTQRSSPSGTHAKPLHSLRKSKPSEVKAALRQYGPFDIAVLALSVRCDHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFI9</accession>
    <name>F9WFI9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002151">
        <property type="protein sequence ID" value="CCD16063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10290"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20172" checksum="3C6C7387FA48998A" modified="2011-10-19" version="1">MSESPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPKKINLYRFLQPAYPLIHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM2</accession>
    <name>F9WFM2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_01280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002163">
        <property type="protein sequence ID" value="CCD16098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01280"/>
    <dbReference type="OMA" id="ANQDRIN"/>
    <dbReference type="OrthoDB" id="138195at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="16"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30219" checksum="B3A66B12F04EE353" modified="2011-10-19" version="1">MDSSPKFLHYTTSPAVEFCDVSMRYRKDQPVVLRNLSFKISAGQKVGVIGRTGSGKSSLLLALLRMVDIEAGDILIEGHPIRSYRLRKLRQLFSVIPQDPVLFNGSLRDNLDPLHTSSDAEIFEALRLVGMRERIATCSGGLESRVVEGGSNFSVGQRQLLCMARALLCHSCKFVLMDEATASIDPALDKEVQHAVRHVFAAHTVITVAHRLQTLAGYDLLLLLRDGRVVETGRPCDLLLDRASHFSRMVSAMGEESARAFAAAVEEGSRTREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX7</accession>
    <name>F9WFX7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 434</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_11550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002197">
        <property type="protein sequence ID" value="CCD16207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11550"/>
    <dbReference type="OMA" id="INSASWW"/>
    <dbReference type="OrthoDB" id="707988at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006851">
        <property type="term" value="P:mitochondrial calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="PTHR12294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="461" mass="51660" checksum="650ED435914DF008" modified="2011-10-19" version="1" fragment="single">MPGRRRAAAGVLFGLAGCVSFGGFAGNFRPPMCWGYGGEAPGVMRHSAAYPKVFGGLTDVRRRFSKYATHNSEGLEVLHLADLIACICLLDEDERQHLNEWVDGAVKQRGKEFTRFFGMVDMNGDQAITYSEFCVFLTLVSTSKKHLKIAFSAFCNSENNSLSREGFRHVLNTLMVDSAVQIVEEVGRNQSNFAVKGRHPPAGLSNDEFLTSNLVNLFFSSARDGQISFDEFWGLVRRIQLEVRKIEFGLYDTQNRGKIRRHHLQKLLFPGVNALHRQGEYKSCSRRVVDDDGSGYPRDEYVSWDFYVKMFDMLRETENIVHGMSLALKARHALPHVGGGNVISSPLESEAPLSSAPTGHLQKPPTSRETALDGGLDSDELYRIFRGCGDLAHIKKHEVDQIVKIFDVNGSGRLFPDEFGRMCRLSTSFFLHSVPIFVEPQRNKIQQFCAHVCSSGSVYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG88</accession>
    <name>F9WG88_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 477</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002245">
        <property type="protein sequence ID" value="CCD16322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12610"/>
    <dbReference type="OrthoDB" id="1732803at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16777" checksum="D1009A11EB9A99E7" modified="2011-10-19" version="1">MGGGRHRTNFGVASIQWRKTSREYPPLWKALEWSMEPSKKEPPETTSSRSVTTKSTIQKRTGRSQRNLQDSSATHQHSEPKLHPHTRLRAIPFPIPLKRKPAPGSFHPSAASGPPSQTEITLLSARSLLGPAFHLIDSLCPHPSSLPIPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE7</accession>
    <name>F9WGE7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_01570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01570"/>
    <dbReference type="OrthoDB" id="1668784at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="8">
        <location>
            <begin position="63"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="415" mass="45684" checksum="BB13EDBFCE4B1C5D" modified="2011-10-19" version="1">MHLFVLCFFSIRKRQEKINHRIVMIIKTSSVGWVMACGLMFCSEVSCVSSYYPKAIPTEAGVSVCTLSRKLKDVPSWTAEKLTELKKTRDEYASKFLDWKLHFHGNSDCGVNESALEDIRTDLEKVNEEINKLSAKAIRAGALAAKSAGRLDEFIVVFANARKTGSVFDETDSKTSNYCLGGGGNPARRRNLFDCFPKGEKIEMGENNLARIPESTPHKEEPNLTGAIKNVNHSAMVGYVKRYDGDENADCNLINGGSGFLGGALNDRLWWGGGILTIGKSFEGELKKDSFVAGGIQDSKDNKALWTASPHTIPHLKKTLAAFQAFKDAAALIAQKFTEIEKIEKKIEPCLSNETMEEGPTQSCFKNAVKLNAELQAANALLARYHKEKGPLPSGSPSPHAQGVMHFLYLIAFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGK5</accession>
    <name>F9WGK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 511</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002282">
        <property type="protein sequence ID" value="CCD16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13640"/>
    <dbReference type="OrthoDB" id="1716379at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394763" evidence="1">
        <location>
            <begin position="26"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18613" checksum="7341F92751B9FCF7" modified="2011-10-19" version="1">MSSILTPWWPLTVCIMRSWLRNCLPNWTCSSDMPSDHSPNVPMRRSYLMPLWNLNTVMSVERTHVDIPPSIVRGICLHDISSHTQMYVYSLRVSPHTSKRSLTTPQLHECQHRLMRVATLAVESLSRVFVHTFHITRVLLSMTPFTHFCVSTRTLSSQLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGU5</accession>
    <name>F9WGU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002327">
        <property type="protein sequence ID" value="CCD16533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14490"/>
    <dbReference type="OrthoDB" id="1722787at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18389" checksum="92B334D8769C0055" modified="2011-10-19" version="1">MGALSSNGNFENCNVGGGKGINSFSRLVNRGFNFSLDNFNNLSPPIYVTDALGELLLQEECSTMASAVRRDIDVEDLPFEIHAFCSAGTDSVKEWLSRWLVETNTFSHNVQGVFERQLDMMLHSEIAIVNPVQESEEGERGETASMCGGESGSQTLPWFVTTGLNDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW9</accession>
    <name>F9WGW9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 563</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_14710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002340">
        <property type="protein sequence ID" value="CCD16557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14710"/>
    <dbReference type="OrthoDB" id="160280at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="244"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="286"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="533" mass="59076" checksum="05670E0785C6BF8D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY6</accession>
    <name>F9WGY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 574</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002352">
        <property type="protein sequence ID" value="CCD16575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14880"/>
    <dbReference type="OrthoDB" id="1722530at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16716" checksum="F73584CED5621229" modified="2011-10-19" version="1">MTWLPISLKNAAKCDKWYQLQNHHIAQSLNANGAWEKLFRVIPVHATFSVSTNKKTTAALFFSLSLMMSRVCGVCAVCSRDVFENGVRRVHVPSSPTNISCRQEEESPVCIVVLLRTCEGLYVVCVLRCGVCGTRAVCVFCGRRALAFCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH61</accession>
    <name>F9WH61_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 600</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002381">
        <property type="protein sequence ID" value="CCD16650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15580"/>
    <dbReference type="OrthoDB" id="1671981at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="527" mass="54353" checksum="C870761B3E744C59" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHG6</accession>
    <name>F9WHG6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002433">
        <property type="protein sequence ID" value="CCD16759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16600"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395057" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22838" checksum="0ACDB6FA6363100D" modified="2011-10-19" version="1">MPPLYTILSFLLLIPFLSPSPIGISMSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPFMHSYVSRFSITDFARNPWRCVGEADGREKVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHG9</accession>
    <name>F9WHG9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_16630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002434">
        <property type="protein sequence ID" value="CCD16762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390396" evidence="3">
        <location>
            <begin position="26"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="358" mass="38233" checksum="DF62E254BB78414D" modified="2011-10-19" version="1">MSKGTHATPCALVLVLLCVVHPLQMAVSAKEGPIASTKEYIILPNGRFNEGGQYLVSHGATERICREEGAILATDHSEATDAAINEVHSTLSHVHNIYSYLGGDATFSASEAQDAGSRCKEADNSTSIHCVYRWNRGLFDATTTNGIGEAFWRGSYRSTPGAGSMNDFPFRWIKDYPKFGVLYPMSRRHYRESKRTWFDVTLETAGSSTEGSVLDERNSTLTGIVGHIQHETPVAPPSPLSGPEGSETASEELNGTNVNETESDDSSSGVSSTEAPAGKVNGGVLAVAILLPIIAIALLLLLWYFCFRRRDEKEDAPLSLREVYSPAECPSPVEAPLTSEGGGAAEGGSPNASPAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS1</accession>
    <name>F9WHS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 689</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_17500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002480">
        <property type="protein sequence ID" value="CCD16865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17500"/>
    <dbReference type="OrthoDB" id="1086710at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="PTHR12547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="37258" checksum="ABEC1A8EDFF9936E" modified="2011-10-19" version="1">MPAALSKAAKMMIMSDGQCEVQSSRSCSLSQSIVPCGSYTGSTSVAEMDEEGRAKVVLAERYKTKYCNNFVINGACPYDTRCMFAHSAEELRTAEMNIADGLITMEAIRRFQRLLHQVTRSSRFARLRPVRTSAPWAMVPAASTGPAAMPHAYHDLRQSSAKGICERAGCAAAATPMAGVRYTHNPYRCDILPLLSRLYSKLPDMFVVPCNRVPDGGSELAQLPEERLSERILDGDETVPAFTERANAQQEQLRCDSDARCREALFLPESLPSDEPDVACTPDSGSEEVDGEVGDRSVCSSIGNESGDVHNSPTYASHFVKGSLRTVGRGVSEESSHTDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS7</accession>
    <name>F9WHS7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002481">
        <property type="protein sequence ID" value="CCD16871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17560"/>
    <dbReference type="OrthoDB" id="1668132at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="236" mass="25940" checksum="3BD0B72D95BDE9CC" modified="2011-10-19" version="1" fragment="single">MNVLEDKMTDNLAAEPEILQDGYNGAVPCDEPQLPPRPTTDDTREKSLSVLEQNGIPTDSPGKVLEDMQLADECNPAITTECEREDEPDNSLGVSDQLEEEEEEGSTADDGDAVSDSAVNEDQPQARKVPVKPSQKDGVRRRHRRVREADYKAVTSSVINCAWGYTFSDTTGHVERSLLPPELLESREARRSHLNTPQALRLRVAQAARQYALAATGPESVEETSAAPRLTVSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW2</accession>
    <name>F9WHW2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002490">
        <property type="protein sequence ID" value="CCD16907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17900"/>
    <dbReference type="OMA" id="AHVRQNT"/>
    <dbReference type="OrthoDB" id="1270774at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="292" mass="32349" checksum="B361C59FA81EC5A2" modified="2011-10-19" version="1">MPSTTLYGFLPYLGFMLKDVGARLAIMSHYLRTKRHMYPVTRHQNVRAYRGMLPWTQDSAFIAPSAFVCGNVSLGHETCVFYHTVIRNYHTINETVIGDHTVVMDRASFLGQVRVGGGVYIGPGCTLDCCSVGDGVYIGAGASIALGAVIENNAIIAAGSSVPKDAHVYAFELWAGNPAQKVEDVTLEQAQEVAHVVHKQIAVGKAHAHAIHEHEHQTAELDAEWLRHVLEAMEKQQQQVALKLPVDIPLEAKRFLAPRVHMRRPEMHMRMSYPVNRIAPWMPKVADQTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK2</accession>
    <name>F9WIK2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002609">
        <property type="protein sequence ID" value="CCD17150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02210"/>
    <dbReference type="OrthoDB" id="1731562at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16595" checksum="7EE416F8549182DB" modified="2011-10-19" version="1">MHGTHGHTPGTSSDAGCTHTHGRVQQDTHCASATQHMMHLPHGEEAKAGKPTHMFSFVYFHYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVHREAHTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK3</accession>
    <name>F9WIK3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002609">
        <property type="protein sequence ID" value="CCD17151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="13829" checksum="3838187FE898F0F8" modified="2011-10-19" version="1">MWAGCGGGANRGAAFHGTGDFYLSVIVGYGAHQPFLFSPKDRKDFFSVCIYSARAPLDARLFSVLLKPAGNTDRNADTVLASFSKIVKQTACNKKAFFPSLWEATGTANDCAEGDGTSNKYGDRLLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU2</accession>
    <name>F9WIU2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002641">
        <property type="protein sequence ID" value="CCD17240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20760"/>
    <dbReference type="OrthoDB" id="1704867at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394803" evidence="1">
        <location>
            <begin position="28"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20218" checksum="0D76487EFD026537" modified="2011-10-19" version="1">MTGSKVLTNATISFACLLLLFHPAGVAQEFNYFRIIAWGDDHLHLSLNSLFYKVYCHMPPRAVPFCVLFTSLEGLQRFASFACVRWPSVHQYDLSFQVVVGLGSICCIAPSHPMRTFNGKLWISVKTVQLPHEVVRIECGSYASKISHHGKYTDNLLGFSRKSLPTTPFCSGGPLPLRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ67</accession>
    <name>F9WJ67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 876</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_21930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002688">
        <property type="protein sequence ID" value="CCD17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21930"/>
    <dbReference type="OMA" id="KSMFEAS"/>
    <dbReference type="OrthoDB" id="1487311at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="181"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38423" checksum="33EB5FFFFC06553F" modified="2011-10-19" version="1">MVKKDGVARTQQGLAAFLKPLKPNKKYLKKMKFIAKKRELAKAAERGHRKKATKKSGPAKVVKKIASSVKEKKTKAVKAAQKKVGRVTVKPTAGLNKASTRKSVASRTERKEDGARDSSDDDAFFALPPPVKKDVDKELIKRVICGEDDRYDDNVGGASTDNVLHSPYLPFLDDYTQQKRSEIVEPDELLERAHTYFADLGRRESTLKREAARKLRELKEINRRGGDKDGFRYVVPRNVTEVVRHMVQGSEVDLTRVSSSFPGDDDEKNRSDEHHHEAADRPMHRRKRRNPCYSDFYQFQVSQRWTQNAERFLEKGRAHKSMFEASKQKRSLRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
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    <name>F9WJ83_TRYCI</name>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002697">
        <property type="protein sequence ID" value="CCD17387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22100"/>
    <dbReference type="OrthoDB" id="1654958at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="552"/>
            <end position="598"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="618"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="889" mass="97662" checksum="560F52AA696E516A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ97</accession>
    <name>F9WJ97_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 890</fullName>
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        <name evidence="2" type="ORF">TCIL3000_0_22220</name>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
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    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17401.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="17727" checksum="980E9FB35F3F0085" modified="2011-10-19" version="1">MLLCDIVLLCDIVLLCDIVLLCDIVLLCDIVLLCNIVLLCGIVLLCDIVLLCNIVLLCGIVLLCDIVLLCDIVLLCGIMLLCDIVLLCDIVLLCDIVLLCDIVLLCDIVLLCDIMLLSGIVLLCDIVLLCDIMLLCGIVLLCDIVLLCDIVLLCGIVLLCDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJZ7</accession>
    <name>F9WJZ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 972</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TCIL3000_0_24620</name>
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    <organism evidence="2 3">
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002794">
        <property type="protein sequence ID" value="CCD17658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24620"/>
    <dbReference type="OrthoDB" id="1599030at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="44316" checksum="64747986DD0AA001" modified="2011-10-19" version="1">MTSCVRQVYIGKHTFPIYSHPTVRVDISDVQCIHDTADDLRGSDRAYNAVNGIHVDRCRTNATYCRPSGPFSDGVDHNAASPCPSSSSRVVRGSHAITTKARGKCVTILDLSGSEKDPSHGDSPRFMATLSRSSPESGGLSSSESFYEKKCLKYNTRSEKRKNNLQRSPFNIVQLSFRGEDKQGMGNDGGKAQHRRGKKWSRSTCLAQEKTDLWNEFLSCYTDGRLDGIISPQEHDDHEMLYYSNLALRLKRGSIVKLEDMNLRGGQRDTLRIQGAYLSQVGHKGFANIFITLDGNSSPIRLVRKGPLTLKQASHMMNEGRAVAVPPHPLKRKVELLALREPLSSLENLKVLKRGGFLPREGWQARKPFSPCENKLLFELPDVTYRSRTLSTLSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK08</accession>
    <name>F9WK08_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02630"/>
    <dbReference type="OMA" id="FPNSRNY"/>
    <dbReference type="OrthoDB" id="1375966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30791" checksum="248F919B802C1313" modified="2011-10-19" version="1">MEMTLPKAVKRKEGTDAHADGYHVCQCYGHTSELPNYKEILKPYTLQGTYAKMKCACPCIQKTKGKHVNSLYCSKRPATCDRVFPNETYRAHGPGPHKVHREVNTSADGAPVRDPATGTRLVFPNASNYGGTAKQRTFPAIGAPRRLTVSERKYENQYDRKEFLKAVLRDEICDRVEAEKRLDELENEIGLRGSRHARMLAEAAEAAKKAQSVESEDEPKTVGDQYNMVMDELRFVAQQPVGSKLNIVRMYYTVEEQEYVDSLGRKATGTVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK75</accession>
    <name>F9WK75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 995</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002819">
        <property type="protein sequence ID" value="CCD17736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25200"/>
    <dbReference type="OrthoDB" id="1705458at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23321" checksum="F074674E64EFA8EB" modified="2011-10-19" version="1">MKLVFTCPAEVEVELTVVEVVRASWEPLETARGFFRGLLHGARQYDAQDGRTLTTDTLQKAMRQVVFEDEGGGDLQTLAMRRWTTTLRYALDPETAMHEFLLAFLGELHTLDRQVGNHRGADAFYKAAGRIVFGEARPSERDLQTLAIQYVARSVLQSEDPEKKARELLGGVLHEARQLDREHHHHQGEEALLKAMEEILQKTSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W390</accession>
    <name>F9W390_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1021</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000375">
        <property type="protein sequence ID" value="CCD11598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25690"/>
    <dbReference type="OrthoDB" id="787710at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="606"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="878" mass="95426" checksum="0501ECD36DDF0F5C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3J3</accession>
    <name>F9W3J3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1059</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000418">
        <property type="protein sequence ID" value="CCD11711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26650"/>
    <dbReference type="OMA" id="ARDNEDF"/>
    <dbReference type="OrthoDB" id="1148913at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="544" mass="58706" checksum="3ABBB0FB79844669" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L2</accession>
    <name>F9W3L2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000432">
        <property type="protein sequence ID" value="CCD11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26860"/>
    <dbReference type="OMA" id="REFPPVH"/>
    <dbReference type="OrthoDB" id="1561535at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17059" checksum="AA9B1CFF949C704A" modified="2011-10-19" version="1">MSSTNATAAPAAAIDDYTPEEHLTSIVMEYRKLEAVNQNGVERMYSAFSSPFKIGNKPCEAARADALGCLSEVIGGFRSKNVVGREDVHADSSESLRAEREFPPVHRCHESVLAYETCILEKSLPKHNSLVASFEARRSQEAEMPPRDGAVAATSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3T4</accession>
    <name>F9W3T4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1105</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000468">
        <property type="protein sequence ID" value="CCD11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27520"/>
    <dbReference type="OrthoDB" id="1686637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="34163" checksum="C7D325962428374B" modified="2011-10-19" version="1">MHHHSVCQCGKLLPHTRARTCLSSCNCLIPLILPHAVAENTTQETMRFFSSAALSFFVLMLHAADVGDAFFLWWRSPICIEGLKLLKGVEDRFSEKLKTYALAINSTESLRAHCERLMEVVGPTADANDVRSRVKALKRFYVEFVKDQSVAAELREEVRSLVQDIKRECGSWIIFFLGNWGIKKRLEQKLADGDRVEKEFQDHITKINNMWAAVNSTGCSVEYYDRLLEQYKRKHGPSNGTGGQPAVQEPANANVSSESTESADSGGSTTGGSNGTAGADGVTGEGSGVPSDGESDGKSNSDSNSDGDSDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3V3</accession>
    <name>F9W3V3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_27720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000478">
        <property type="protein sequence ID" value="CCD11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27720"/>
    <dbReference type="OMA" id="HIGFTSN"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="41618" checksum="1F727CC7995A6BE6" modified="2011-10-19" version="1">MSLRWAMLLVSIASWYIAITLLLIGPSGVVTRVPPAELTRNYPDWMRQALAFTPAAAIRKWQHIDYLLVLGIPSVDMLERQRRRNLQRTTCWQYDGVARRANGFTGAMLPLYVLARHPSNGYAYTDAMRREVLKWSDMIALPMYEGKPSTNKKVGGGGKWGTEAEIGMSRKTFYWFDFALRMFPNASYFAKGDDDMFLRVPQYLADLRSLPRRGLYWGTMDRFTVDGYRFTYAFGALYTLGRDVAERFVSYLPLKSVIDLPYSEKEAHKFKALYLYAEDAMVGITLKRAGYSSELFHVNEKKCSFHDIHAGALVGPLSSSSVMVHHVKEEDYGALMKRFNDGKVVAPRNLSSSEFSSRRMFMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K2</accession>
    <name>F9W4K2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_30110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000567">
        <property type="protein sequence ID" value="CCD12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30110"/>
    <dbReference type="OMA" id="PIRYTPR"/>
    <dbReference type="OrthoDB" id="167285at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="60"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="640"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="693" mass="74848" checksum="4C316D33CDE4A15E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4M9</accession>
    <name>F9W4M9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1205</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_30370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000580">
        <property type="protein sequence ID" value="CCD12123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30370"/>
    <dbReference type="OrthoDB" id="1170065at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000840">
        <property type="entry name" value="G_retro_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036946">
        <property type="entry name" value="G_retro_matrix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010999">
        <property type="entry name" value="Retrovr_matrix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01140">
        <property type="entry name" value="Gag_MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47836">
        <property type="entry name" value="SSF47836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="SSF47943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="2" id="KW-1043">Host membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag_MA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Gag_p30" evidence="6">
        <location>
            <begin position="211"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="417"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="473" mass="52851" checksum="9CA4BE2DF6E7B3C1" modified="2011-10-19" version="1">MGQSVSTPLSLTLEHWKEVQVKAHNRSVEVRKGPWQTFCASEWPMFGVGWPPEGAFDLSLIAAVRRIVFLEEGGHPDQIPYIVTWQNLVQFPPPWVNSWTLNSSKLTVAVAQSDAAGKSGPSAPPKIYPEIDDLLWMDSQPPPYPLPQQPPAAAPPQGPIARGAQGLAGGTRSRRGRSPGEEGGPDSTVALPLRAHVGGPAPGPNGLIPLQYWPFSSSDLYNWKTNHPPFSENPSGLTGLLESLMFSHQPTWDDCQQLLQVLFTTEERERILIEARKNVLGEDGTPTALPNLVDEAFPLNRPNWDYNTAKGRGRLLVYRRTLVAGLRGAARRPTNLAKVREVLQGQTEPPSVFLEHLMEAYRRYTPFDPSSEGQKAAVAMAFIGQSAPDIKKKLQSLEGLQDHTLQDLVKEAEKVYHKRETEEERQKREKKEMEERENRQDRRQERNLSKILATVINDRQSEKVKQGSWATGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R7</accession>
    <name>F9W4R7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03150</name>
        <name evidence="1" type="ORF">TCIL3000_6_3950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575319">
        <property type="protein sequence ID" value="CCC91140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000594">
        <property type="protein sequence ID" value="CCD12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_6_3950"/>
    <dbReference type="OMA" id="QSTEKVW"/>
    <dbReference type="OrthoDB" id="977939at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC91140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="325" mass="36965" checksum="0A9EF576766D7AFF" modified="2011-10-19" version="1">MNRLVCLLSKKQSTEKVWKAVPLPYQFHTSLETGDWMRALHAYQRHPYHAPPVDTFDLLKAVMHATGVRVEDVKSRFNEKIRLSAILQKKTPEEVGWEVFWQALNKGDSKTISAALMGARLSSVVQQIATAEACAVLLKSAGENWTKVLVDDFPFATVTRCNLVQVALLLERWDVAVELLKHVRVTRSDMIMLWELFEKFDWEKTLMLISACPKNSVPFDRALSHILRSGCSLRHLSEHLENAKVLGDADVVAPLLAYAVEIKDWEYVGRGMDHLVDIGQITQPAREVFEHMGKIHGTERVCRRLSENGIPLHRITVERLEGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V2</accession>
    <name>F9W4V2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000614">
        <property type="protein sequence ID" value="CCD12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="17307" checksum="B8084E64C58461DE" modified="2011-10-19" version="1">MAVCFFCTLTAFVKRRRRVTRSFSVHLQRVMLNRCSHRKSVFCQKRPHYGWCQRVRRCVTCKASSFRHQSCLLALLMGKLSRHRSCWTAPLPIFVNQMQRDRFSLCLCALLLTYASHCSHCSNLFLYRICILHFCSFLVPLLCHEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z1</accession>
    <name>F9W4Z1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_31390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000632">
        <property type="protein sequence ID" value="CCD12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="1460684at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_L32e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_L32e_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="PTHR23413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="SSF52042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="15378" checksum="92DA6A56010FB3B5" modified="2011-10-19" version="1">MVKPIVPRKIVKKRTKKFTRHRYELFPQLSSSWRKPRGEDSPVRRRYKGQKAMPNKGYGSDRKTKYITPSGFKNFPVNNVKDLYMLLMQNRKYAGVISHTVGARARKAIVRKAHELDVRLINGNAKLRKVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W532</accession>
    <name>F9W532_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000650">
        <property type="protein sequence ID" value="CCD12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31760"/>
    <dbReference type="OrthoDB" id="1696047at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="22952" checksum="4C43105F61DA1DFD" modified="2011-10-19" version="1">MLGRLNDNTIKDIRYLVGDGIITLCDWALRGASTLLGHVARGTLDEAVRVARKHPRSPITSGSMSVQSGNEASDKLTHQVAGTPSTQRQPGGTEDREMREVVWKAFKSWEGACLVDFLTQECGKTHGACNPNVALAAFLEDPSHYIEEDERRKEAVEKLPGKLHHLKGCIFRDVPFLRAIGITTRGYWVHRLCYRDMPTPITNCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W550</accession>
    <name>F9W550_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000658">
        <property type="protein sequence ID" value="CCD12297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00270"/>
    <dbReference type="OMA" id="IGSFEIM"/>
    <dbReference type="OrthoDB" id="444004at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="Peptidase_C78_UfSP1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="489" mass="54943" checksum="73D85D554E7571B6" modified="2011-10-19" version="1">MNASNTLHEESLPLLIVRKNQTTIAIVRDNSLKGCFLPFALAACDIVQVGDKESLEAARDNGMLNTTVVEWPTVVKVRVGLCNAIELRHWVMLSRGKACDSGETVIRDFMATEEGLEGLLLWLEGLTLCGPWEMTLASEPVIDGVKVREDFGCLRLPKEGEDINERVILAESASEVAQYLKGFLSSFFFSGVTCPTAVFWPSQLQHAVNIRFSSPKDRVMEHDALYLPMCSLFHVEKRIQNWSAGKGLQASAPHATFRTGESWERHLTRDVHNFLKGYTPVEGGEVCLVSGSYDYYHYLVDGFKDSGWGCAYRSLQTILSWFQYEGQMLEPIPTLRRIQEILSVKDAEKMNRKNFVGSKDWIGSFEIMIVLQHFLPGIECTIRRMESGSELDTNPDVQRVLRDHFAAKRACPVMIGGSSYAHTIIGIDVNLATMEAQYLIADPHYSSNETVVKTVVSKGHVGWKKAGKFFEPNSWYNLCIPQVNSFDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W561</accession>
    <name>F9W561_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000662">
        <property type="protein sequence ID" value="CCD12308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32020"/>
    <dbReference type="OMA" id="ACEKRPQ"/>
    <dbReference type="OrthoDB" id="1098380at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="PTHR24054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="348" mass="40652" checksum="F409B9C81D1C3645" modified="2011-10-19" version="1">MSTLPQCSPDGAHRYARANVDRPREYWDYETARIQWSSPERYEIAEKIGRGKYSDVFIGWDVKLRRQVVIKVLKPVKKKKILRELKVLQNLQGGPNIVELYDVVRDPCSKTPSFIFEYVQASDFRTVFPTFSDYDVRYYIFLVLQALEYAHSMGIMHRDVKPNNIAIDHKRRDLVLLDWGLAEFFHPDTPYNARVASRYFKGPELLVELPMYDYRLDMWSLGCMLAGIIFMKEPFFHGKDNNDQLARIAKVLGTDELFDYLNKYGLTLSPVLEAAVGRHGKKPWTAFITQENQHLCSKDALDFLDQLLQYDHVKRVQALEAMEHPYFDPVREECRARLREREAASAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5A9</accession>
    <name>F9W5A9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1302</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000688">
        <property type="protein sequence ID" value="CCD12358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32430"/>
    <dbReference type="OMA" id="RHTQANS"/>
    <dbReference type="OrthoDB" id="380051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1802" mass="202052" checksum="2BA7E07C9B0B3C20" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5W7</accession>
    <name>F9W5W7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_34370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000789">
        <property type="protein sequence ID" value="CCD12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34370"/>
    <dbReference type="OrthoDB" id="1673260at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394707" evidence="5">
        <location>
            <begin position="25"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38933" checksum="9B02F6A18FB4BE26" modified="2011-10-19" version="1">MTRMMMKFWMMMIVTMGVSTNVEGTDHNHDAHNALCDLLSVSVKKWGEVKERKHDDPLRNALKQTIFGYGSVGEDLDKLKTKFPKDYEGVEGRLSSRSNWCGQPHEWDGYFKDEDRWSGHSAPHDMVCLCTVGEKGWPLNESKSYSDAETTLCGQDKQTLGATDGKGWDDDRKEKPGENHVNATWFGVTVSCLKGETGGDLKKALKNFLGKLEHNPGHGYDNRYRLGKGNVSSYAACNGKPELGVCAMYYNTTKPLPWWTELERALIEDEQIQKQREEEERRKQQGETEKQDLPKTAAITSGPSTTNQTEGTHKNTLHEAIRKLNMTSGTTISQPSSWLLSALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W620</accession>
    <name>F9W620_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000811">
        <property type="protein sequence ID" value="CCD12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16643" checksum="9E63AF08F1A46BC7" modified="2011-10-19" version="1">MRHARKGHMARIVVRNSLSYFILLRSSKVSGHNVPILSSYQLRERGIRFTGVTETFFLIAIVVQLCPILYWPLFGTQVFIGSVKGASLAMFSFRRVSFVLYLDHPRRGTSGRATLHPLPTSTKLDCCDSCPILESVKCGNGDGNAHINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W634</accession>
    <name>F9W634_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_34980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000819">
        <property type="protein sequence ID" value="CCD12637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34980"/>
    <dbReference type="OMA" id="VIRTRNY"/>
    <dbReference type="OrthoDB" id="458757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="576" mass="64268" checksum="E40D611100C20B93" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U1</accession>
    <name>F9W6U1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000936">
        <property type="protein sequence ID" value="CCD12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="16243" checksum="4E9B42488CC60D96" modified="2011-10-19" version="1">MNGDQYFFFLRNECLKHEKKLHTRSSFFFRFITFYHLLRLRKRGGFFSRCQHHQCHVALHTKRVKHVFCTSLPLVQRKLVMRNAWIAVCAAKLSVTGQDEVGLHHYLSSDRYQREVTRETGTKNVIGKDKTLMKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6V4</accession>
    <name>F9W6V4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1530</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000941">
        <property type="protein sequence ID" value="CCD12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37450"/>
    <dbReference type="OrthoDB" id="1449637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30139" checksum="74E2E32AB2236A93" modified="2011-10-19" version="1">MIHKPQQRKGCEYGSVTRVCNWFTAVIAFFKVFFVPPLPSICCFSPPHSSLTCYFRRRILVAMSRQSGQQRAMNALGNQFTCAVILSSAARHFSNDANNFWLLLQTDDGALSPETIVESIHRFCIAHDMKFVDCGSDAATLVHEREAHVALVRCSDATEITQQLLQLGGNPSVITLEIFYSEATTWNPANVMPSDEWQWLRPTPSCLAEMRHSSSGTCGTVASLPATMRCAKPVIRAQLPALGPGSVPWSAAVTLEGMMREVGYKVGCLSKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6X4</accession>
    <name>F9W6X4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1532</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000944">
        <property type="protein sequence ID" value="CCD12931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37520"/>
    <dbReference type="OMA" id="VGTIMND"/>
    <dbReference type="OrthoDB" id="1460513at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="44186" checksum="6A0CCEA0DEBF7AEE" modified="2011-10-19" version="1">MSDEERTKWLRRSYTRSIPTTLRSLKQLEESAADAEAQWHELAKSLVSTTEGEGEGEREEEVPMEIRREISRKAEAFASQLKAVMQELTAQMGRAANLGLDTQTFEQYCVWAAATSQSSLSDVGLVDEDRRSCELLARVCMLCLCVSVVIGDLELLVSTMSFAESHRLVERYTRDISYCGNGGCNGILRSNVACTFFLGCPHDGATRLPDGDVLSACILLYCLFTQSGKAATIATSLTAQGASLHALETASESEGVLDSSALYRMSFLHTVLQMLSWVEGEDFPRIHRCLVGGFHTEDGTRVPLPPLISLFISVMLHMIVRRRLVDARLHDAFRPVINVEAPAGGDGGRSVRVQAPYSLGELYDSCRGRFLGLCFAIQRDCMSVSGPWPLPTTVYEKLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z6</accession>
    <name>F9W6Z6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_03890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000953">
        <property type="protein sequence ID" value="CCD12954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03890"/>
    <dbReference type="OrthoDB" id="1722086at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005678942" evidence="4">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="15"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17988" checksum="7B90A4F3262CBDF2" modified="2011-10-19" version="1">MRSLQILLITWSLSAVTKGNNNGGINEAEFREMCSFIKLLQKRPNIPTLEAQDSTSEIPTQALRAVNRIRILNASTADASTYDSLAKGEEFAKLKENRVVVQMGEQKWAELVQLWKDNQGQFFPDPRKLGADELRVIHGKLGSILQKAENTYERNQKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B8</accession>
    <name>F9W7B8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_04100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04100"/>
    <dbReference type="OrthoDB" id="1682910at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389891" evidence="10">
        <location>
            <begin position="26"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD13084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="33357" checksum="24FAA9B81DFEF79C" modified="2011-10-19" version="1">MVMGSCLEWLFPAAFILLFPEAAWGTGPKAIPTKAGAAICTLSKTLKDVTPWATQQVTAGAAKISHLEMKLLEWQSKFIQSKSKGIGSETCKITGLLFRQVRKEIDKARKEVEKLEKEASRAAAFAANSAGRLDEFITVFANARGESSSYCLGDGKAVTAGELKDCFGGEDFSEESLVDIGEKARIEEPKLDSKIEGIKHSVLKSHFTTGSGGGCNLIKGGKGGILGNTNLEKSLWWGGGILSIGRNYSGTNSDELIAGEITNATNNKEKALGGKPRPTYRAPQERLGHFQGFQSRTGNYPSQSRKHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7E7</accession>
    <name>F9W7E7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001014">
        <property type="protein sequence ID" value="CCD13113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="SEAYGLC"/>
    <dbReference type="OrthoDB" id="1426075at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="PTHR12403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14910" checksum="33D833F00D1501A2" modified="2011-10-19" version="1">MLMVVGPDDSTLFECEKFSDGESTNMLHQLALYASMDLLDDALWKTGDFFIPSVDKPVDGRFCVSAYVGFAPIKLLLMKESESEKETRLFLSEAYGLCVRYLMNPFSSLKSPVRPTLGENLKSLYQRFIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7I2</accession>
    <name>F9W7I2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001037">
        <property type="protein sequence ID" value="CCD13148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39270"/>
    <dbReference type="OrthoDB" id="479815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="674" mass="75845" checksum="1C7095C4BF9F7266" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P4</accession>
    <name>F9W7P4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_39860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001061">
        <property type="protein sequence ID" value="CCD13216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39860"/>
    <dbReference type="OMA" id="IAMLEWI"/>
    <dbReference type="OrthoDB" id="1037842at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="570" mass="65471" checksum="549E433D43E6E59A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7T7</accession>
    <name>F9W7T7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_40280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001079">
        <property type="protein sequence ID" value="CCD13259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40280"/>
    <dbReference type="OrthoDB" id="1674352at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394600" evidence="5">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36913" checksum="9610E32A80D2C13D" modified="2011-10-19" version="1">MMRMKIWMVVSVAIGVGAQQSGTNHNSGEHHRLCTVLKAAVSKWENSGGILSHSLKKALHQTIFGNESGGNIEKLRKQLPEFYDEVLKGSATRFTPCGGRESGHSASYDMVCLCTAGENGWPVNNSDNAKLCGKNANELGVRSQAKGWYIKGEGKDQITATWTNVTSECLHGDKEKGEKLKDTLKEFIDNLNQTRKTGYSNIYRLGEGDFENKAHCDGSPANGLCVMYYNGTQKMNHRPWWEDLEKAIPEEERFQEEKKKREEEERRKQQEKEKHDILQAAALTSSPATNQTDQQHNKANITTQFHRLNITSGTPTSMPSSWLLSAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7U4</accession>
    <name>F9W7U4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_40350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001080">
        <property type="protein sequence ID" value="CCD13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40350"/>
    <dbReference type="OrthoDB" id="1677827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388783" evidence="5">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="37404" checksum="425700AD2C5FED47" modified="2011-10-19" version="1">MMRMRVWMVVMVFFGVAASADEKDHNGAQHQALCGLLKAAVTKWGEVRGREPADPLRKALGQTIFGKVEGGDLSVLKVLPTDYNNVEGRLTSRGTWCGQPFYETHTAHGWRWSGHSAPHDLVCLCTLGNNTWPLNHTQKETTLCGKDGNALGGSDGKGWSNGGSGNEHVKATWVKVTVPCLNGEAGGDLKQALNEFLGKLQHKPDGDINPSRYILGENNVTETDSDACTGSPKLGVCVSYFNATSPMPWWVALRNALPEEEKFQEEKRREEERRKKQEEEQNQEFPKAEALRSGSPTTKQTEQSHKDNITDKLRRYNLTSGTPISQPSSWLFSVAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Z4</accession>
    <name>F9W7Z4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1679</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001107">
        <property type="protein sequence ID" value="CCD13317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40830"/>
    <dbReference type="OMA" id="HIMLARE"/>
    <dbReference type="OrthoDB" id="706511at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="453" mass="51626" checksum="4195A031BC4E5BBB" modified="2011-10-19" version="1">MDRFINLGGCALFVIVTGVWQYFMIDWMRFDNFLEKNENMLPCAVPNGDSHHINFLLREQRTKVHERLSRDGGASNDSAGGDIHKASVLNDGLNKSVEFTSATHRSVGTMAVFLAGDFDSHGHGSLTAKFTQRLLYSLRVALLTGSPWLIISCSAEERGNIENILWNVRSPGNFLFPNKFLAILPPSLREVAKQMRDSMSFASSLSNWTEGGDIIEHLSSRVDSEDNGKPVVSPRVLRHGRSRWIVPEVVLISSKQLWSRSTETEFRDAVYVFSQRFITSGLYDYVDEASQQKNTEFMCGRKGVFDVFAVGSMFNERYQHIMLAREFRRLKYLHPHDPIFAQRKHGKKIALWLAENVNVLTASSPNSPPEWLLPSPLFVTTAPDFVAVRRGWWFLRPFAPLAHIIYFNYCRWIFCLRCTISSYLPCSFVSEAFSLAWAILTERCSLIDLFQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W887</accession>
    <name>F9W887_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001150">
        <property type="protein sequence ID" value="CCD13417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="15935" checksum="2060967F4AE52309" modified="2011-10-19" version="1">MIRGGEKNIAMQSSVLCAFGISLHGACLFHLLLSMLPMHVVAVLSVGVVEGCVAAGGFSFLFGMILFSPLVKPSILWPWSSSAFFRHYWYYYFVAFPTPTLPLACGVHVETIIRDNERRGSLVLVLVQQGALSLVSLTRCVSIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H7</accession>
    <name>F9W8H7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42550"/>
    <dbReference type="OMA" id="DIIYQNP"/>
    <dbReference type="OrthoDB" id="1191764at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="PTHR11875"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="SSF143113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="21234" checksum="E11D6B99CA9B3B70" modified="2011-10-19" version="1">MELVPQDVIDAIAKCSAEVQRIQSQTDNALVGIRAEFRERIEVLFEKRQEQLGKVDGFWSEAFTAPESPVRSLLCGPLDQRLARALTDFNVKTSIREGTICRCVMVTFRSNICVEEGTYSRELDSTLKTISVKPIVWKNGTERTRHDSVFKFFSTDETNEEFIEDVLAAFDELFQNPFLVLEAETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W925</accession>
    <name>F9W925_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="15272" checksum="2B1EAB7E1173E518" modified="2011-10-19" version="1">MRCCPAYVRGGGCPETRTSVPTLGSECLPEGQHPYPSAWSTVRAWGMLLHSQPHIPKDSFPSGFPLSGGVGLARLFRVGRTTPNNSTSERDASHWRPLSCVQGGSWDASLIGGTMLHTSTFGKLSSSLGVVGRDEQDDEDTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W980</accession>
    <name>F9W980_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001277">
        <property type="protein sequence ID" value="CCD13771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04830"/>
    <dbReference type="OrthoDB" id="1722555at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20206" checksum="339E808681CF30E8" modified="2011-10-19" version="1">MAMPDTRSTRWRASRIRNSAHLISLRFSCSSSMRSSKRMASACASHRPILARFTSSFRCRDARKAVKASILLTLPSSFWIMLVKASLSAFRSSLYLRRCSASRRRSFIFTKGRLEVSCCRGAHSPVWQTLVPENVRVLANVQWRTMRQSQAAVSSGSGWNMRFAGTCSRGVKGRANHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9B0</accession>
    <name>F9W9B0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_45000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001290">
        <property type="protein sequence ID" value="CCD13803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45000"/>
    <dbReference type="OrthoDB" id="1673529at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394622" evidence="5">
        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="38660" checksum="4547D115F864696C" modified="2011-10-19" version="1">MMQYWIVVMLFVGIGKAEDSEKDHNGDAHQALCDVLKEAVGKWGDGGKHLSEPLQKALGKTIFGKKSVGETVESLRGKLPDDYEKVKDLLSQRYFWCGESKQEGESSGINPPRRSGHSAPHDMICLCTPGDGGWPLSGTEGSKKILCGRGSEEFDVKRDKEGWGISRQGKNQIIATWNVVVTECLKPNGEGTKLKDALEAFIKKLSTLVTGIHPYQSLGKGNFISNYSCSGTETQGVCVKYYPEEKLAIPWWKDLRQAIEADELEKKEKEESEKRKKEAQKQRQPQKQDQSQLPHEPRTAALRSIQQGSHEAEQANPENISTPLATLEDTSGTLIISPCPWLLSAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9B9</accession>
    <name>F9W9B9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1846</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_45120</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001293">
        <property type="protein sequence ID" value="CCD13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45120"/>
    <dbReference type="OrthoDB" id="1715228at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="16"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="202" mass="21706" checksum="29B7B313C8283842" modified="2011-10-19" version="1">MKLLEWQTKWVQSKSKGSDSEELKITGLLFRNVRKEIDRARAELEKLEKEASKAAAFAANSAGRLDEFITVFANARNKSGTGFCLGDDKPATNEELKNCFSGKDFSEESLVDISERPSVQEPNLGAAIDSIKHSAMSSYFTAGSGRGCNLIKGASSGILGNKNLEKSLWWGGGILTIRKDVDGSLGSGELPAGEIESVNGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9C3</accession>
    <name>F9W9C3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001294">
        <property type="protein sequence ID" value="CCD13823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15832" checksum="61A6AF0DDDF79450" modified="2011-10-19" version="1">MNSSFRALPFFFPLPCDNVSTLMDGNGFLGRCTFIHVFFLLLLPILSLLLSLRFCFPWYRPRSIFPSYHGAVRRAAEAGGDKKRCVFNSRAKRRDVVLQMSEPSTSSFALHCFFFFSRMRTRREEKMRMRSVSLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P4</accession>
    <name>F9W9P4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001334">
        <property type="protein sequence ID" value="CCD13948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46330"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20218" checksum="DA554F2E725CA60E" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPKKINLYRFLQPVYPFIHSYVSRFSIRDFARNPWRCVGEADGREQVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA39</accession>
    <name>F9WA39_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1927</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001383">
        <property type="protein sequence ID" value="CCD14095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47620"/>
    <dbReference type="OMA" id="PECNNEE"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="19793" checksum="9A79DD504A877F51" modified="2011-10-19" version="1">MLVSCDTNDLGCRAGFTDTAFKWIVSSNNGNVFTEQSYPYASGGGNVPTCNKSGKVVGANIDDHVHIPEDENAIAEWLAKKGPVAIAVDATSFQSYTGGVLTSCISKEVNSAALLVGYDDTSKPPYWIIKNSWSKGWGEEGYIRIEKGTNQCRMKDYVSSAVVSGPPPPPPTPTFTQELCEGAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA43</accession>
    <name>F9WA43_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001387">
        <property type="protein sequence ID" value="CCD14099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47660"/>
    <dbReference type="OrthoDB" id="1522976at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="459" mass="48131" checksum="AA41AF95BE8733E5" modified="2011-10-19" version="1">MPPPPGGSQAAPPAPGKDHQIIPASVIPAYDPSMPPPPGGSQAAPPAPGKDHQIHYAPVIPAYDPSMPPPPGGSQAAPPAPGKDHRIIPAIVPQAYDPSMPPPPGGSQAAPPAPGKDHWIIPAIVHPAYDPSMPPPPGGSQAAPPAPGKDHRIISAIVPQAYDPSMPPPPGGSQAAPPAPGKDHRIIPARVRPAYDPSMPPPPGGSQAAPPAPGKDHRIIPARVRPAYDPSMPPPPGGSQAAPGETKRMFPDYNHQAALPPGGSQALPPDYYQRPLLTGNGQPPHVERGGGLANEPAGEDRSAVNEWETGLLVAPCRQPCFCLCSCCCPCCCTYLQRKKLLQGDWSRYSCCAGICCKKTCCVIKDCEPCCLCLETCCCFGCALHGNRFMIREHYGLQNDCCDNIIMCAGDCCGMLACCTKNKAVKSIANVLFFITIGCVLAQHEHQMKVCGYPRGHKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC1</accession>
    <name>F9WAC1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001413">
        <property type="protein sequence ID" value="CCD14182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48300"/>
    <dbReference type="OrthoDB" id="1669475at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394636" evidence="5">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="40093" checksum="5734F0120D79FC3B" modified="2011-10-19" version="1">MMGLRIWIFFLLVCGVFGEQKNDIARKTDHNLEEYNALCNLLKIAVHEWKELKSRGNEGPLKKALGRTIFGDDSGGDLEGVKSKAFPQVYNGLKESSLSRLLWCGGPYDEDSRKNWKHQPRWPGHSVPHDLVCLCTTGGHGWPFNNPAGDTVKNSLCGKPKEALEASENQGWGTGIQSHKGEKQIKATWSSITEDCLKDAGQEGNLKDALEKFIAKLNCTGASNHGKRCKLGEGDFVTYPCNGNEKVCVMYHNSTDTMEHKPWWVDLKNVLDTAEQQKKNEEEGRKQENEQKKQKAQNHEKSQPTQGPRTAVLTTAPQGSQEAEQDDTQNIPSPLATIEEESGTLITPTCTWFLGALFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ6</accession>
    <name>F9WAJ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49070"/>
    <dbReference type="OrthoDB" id="1678514at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="300" mass="32512" checksum="ABF2087B42541CD1" modified="2011-10-19" version="1">MSALFHNTKEEARTFSLMAVLKSGSLPPLTVLPPQDFLAVGPEDCLGYPPNLTVKTPLHTLPFVQSVDPDTIQVLAVSHHKILEDLQLGRYGLQHSSTRFLIMYAPGVFFKEFCNTPCRVCSVFKLEAPLFGHELGKRQDLSVQTSRLKHLSNTGRPRATQWSLRGNTPIQTGSITDGAVAAAAGGVQVLVAFGVSAAREAQGEGLDKRCRGLVYSALNGVLQEESGEFFHPGMILQFRQLPQRCDLAPGQIPNGCAHAHPQPGYQAVELLNHFFQHGCFLHTARGAGVSPPGSNPPLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAK7</accession>
    <name>F9WAK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein TCIL3000_4_3490</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_49170</name>
        <name evidence="3" type="ORF">TCIL3000_4_3490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575317">
        <property type="protein sequence ID" value="CCC90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001444">
        <property type="protein sequence ID" value="CCD14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49170"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_4_3490"/>
    <dbReference type="OMA" id="ERNELDC"/>
    <dbReference type="OrthoDB" id="104740at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="SSF52087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="62"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="284" mass="32498" checksum="5A0903CF6A5D2ED1" modified="2011-10-19" version="1">MSSFLQELGPVAVSHRQEVEEVKRQLNMRREELDCWVYSFLENKKFDVEETVAKLKRRLAMEAEEMAKYEFTDYMHESLRSGIIQVIGNDKSGRTVFYVTVSRDKKEADHRDEKKRTFDLMVSYGTQLRADNKRGQMVLLVNYENASLWSNVDLPFLADLALRLSKFFPGCVSKVYVCNIGATVCTVLVPFVSQLPASLSENIKFLTSVDVSSGSLLEFIDEDVLPVALGGKNDCDNQAEWDRHGEVIETYFNQMREAVVDRGLTLKDWELECLDLESKACCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAQ5</accession>
    <name>F9WAQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001469">
        <property type="protein sequence ID" value="CCD14326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49590"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388917" evidence="5">
        <location>
            <begin position="22"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="16"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="443" mass="49438" checksum="7DDBDC01EAE8B4AF" modified="2011-10-19" version="1">MVKCTGFPLAAYSACVALALGALGTAGTKPDNEKEFEVLCRVLRVAEGTPAPVPDNSSIELKAVQQARLLARYTDVNEEQYDLVVRQSKQDFSKEKLTAEDEDFLKYTVGRRTAHEKIVIIVRKMERIYKRIREKIEKATKARENAVKLLAHSIYGNTVDYLPAEENITKLLSHVDKESIFNDPEKVVTLDGYYYARGSCGAIVHEAGRTLINDFYCLCVGVDNSSAPCVDDIKGADTCHYWDDTDERLNCNISRWTQLNSDGGSEKDLSEGWPVLKSKCRKTSNETDLTAEAIKVALKGFRDMLGKQYNSGNSDFPTTLTVRDFVLGKMSILLANSVTYDQGGCVGHKNQTCVNYWSALIKGKGIEWENNLINAMNEIETVTTEVEQAENLSVVLFSLKKEAERIYGKEIIGNVSWEFDGITPALRARDLIAYTTIACFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT5</accession>
    <name>F9WAT5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WGS project CAEQ00000000 data, annotated contig 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_00600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00600"/>
    <dbReference type="OMA" id="RVIQNRA"/>
    <dbReference type="OrthoDB" id="1195966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE" evidence="11">
        <location>
            <begin position="37"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD14356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="26027" checksum="ACF940370F7167A9" modified="2011-10-19" version="1">MSSLLPVYEDDFNETAEQVRDVLTKLQSSLDRSKDAYQPPPTTGPESRSQQGHTLQQGISHLRELLTNMSYECNDIEPPAVKEEVKLRVDDYRRVVTLLDKEVTRARQEAREADRLDLMNGGGSNVVGEEGITDERSRMLGTTGRLREGTGVLNKAEALLHSTNEMGLETLSTIRGQTEQMRTIHTAVIDVDTDVVDIRGILHRMQQAARNEKIIFAGVVALLLVTVLIMIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU7</accession>
    <name>F9WAU7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_49880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001482">
        <property type="protein sequence ID" value="CCD14369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49880"/>
    <dbReference type="OMA" id="QFWITAF"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="5">
        <location>
            <begin position="61"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="458" mass="49809" checksum="7FADF074F7ABE073" modified="2011-10-19" version="1">MTSAPAEDTVRTAIAGALPDEVGITQPDSEKATTTPPNESGGGCLQRFMDPFLRLIPYGGMASNVFNLESATLGAGIVMLPSGFHNSGIIIATLMLVYICFTTVYSIRILVITKDKTGFRSYEELSRGLLGRGSDYFTAFLMFVFCFGTCVGYVISVGDLLSPLLEQPTTNEFLQSTMGKNLLVSAVWLVTMLPLSLPKEINSLRYASAIGVVCIVFFVLCMIVHAATNGLKTGVSSDVRLFGDGWGILNGFTLFVFAFICQVNCFEVYEEMRKATPQRMTRDSTVAMSMVGILYFLSGLFGYLDFGDEASGSVLKLYRPQDDVMMAIGYIGIAFKICGGFAICIQPSRDALYYVAGWGKTSDVATWKNLVVSGVLSTLALVLGLVLPSIEVVFNFLGSFCGGFLAFILPALYYMYAGNFSVREVGWFNYIVTYQLIFVGVFAVVFGTALTIYDEVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU9</accession>
    <name>F9WAU9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2019</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_49900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001485">
        <property type="protein sequence ID" value="CCD14371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="777540at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="466"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="958" mass="107574" checksum="146E16F4405633E9" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB02</accession>
    <name>F9WB02_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2041</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 793</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19730</name>
        <name evidence="2" type="ORF">TCIL3000_0_50440</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001509">
        <property type="protein sequence ID" value="CCD14428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002595">
        <property type="protein sequence ID" value="CCD17124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19730"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50440"/>
    <dbReference type="OrthoDB" id="1701886at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23335" checksum="02045BBA52789E65" modified="2011-10-19" version="1">MIRALHRGCQPSRGSAKDMRQMLGRLHDNTIKVVRCFVGGGIITLCDWTPRGASTLLDHVPRGILDEVVREAHKHPRSPITSRTTSVQRRNEASDKFTHQITSTPSTQRQPGGTRGIELKEIPRKAFKSWEDACLVDLLTQEYGKTYGACDPNATLAASLEDPSHYIEEDAELEEVVEKFPEKLNHLKGFIFRDVTFLRAVGITTRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB91</accession>
    <name>F9WB91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_51300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001546">
        <property type="protein sequence ID" value="CCD14522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51300"/>
    <dbReference type="OrthoDB" id="1664214at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390093" evidence="4">
        <location>
            <begin position="24"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="96"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="413" mass="45095" checksum="D6E080D52E04D2DC" modified="2011-10-19" version="1">MKHMVKMLLASLVICCFLKDAAAQGAEVKGTDNAEQFALLCRIYNVAKNPPINHVDIQDPLKIVKEIDSMNGSFAEEKLVNETEQMGNSSGVQLSPTTTREAEVAQALLKRISQKAHNILKEIVKVNATRNIERVKTDFAQVIFGEGMNESHLCDGVLKDVGERGKACGAAGLHAKGESAGRNLVVDFFCLCAQRNNEGIYDACKVKVGSKSDKHSWGSGDPTGSSSMWASIKTECENLMHQHPKSTEEGHEVLRDFLTHLKSGGVYRWGSRSIDGSNRKAGMLGTSACKNGGDGKGPVCDGNKGNSLPGGICVYYGQESEWNDIAWLKKIKTALNAVDALNNKTTTIQRDIEKLQTLLHRAEKIYETAKVITEIQNPVVPTILQTAAKRLTAYNAAWTLPPIHHLILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBB1</accession>
    <name>F9WBB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001558">
        <property type="protein sequence ID" value="CCD14542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51490"/>
    <dbReference type="OrthoDB" id="1706847at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21713" checksum="209AD096A6D82358" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVDVLLDGVTSADRINLYWFLRPVLACLPVDLVCFTLRDFVRNPRHCIPESNVCDTLWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYIDNDDTPLEAIDEEIWRRCRRPPPPPYQPYQGVVLVEATPAFIQVPYSTVGYLVHLPVTPRAWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC0</accession>
    <name>F9WBC0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_51580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001562">
        <property type="protein sequence ID" value="CCD14551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51580"/>
    <dbReference type="OMA" id="REICCAD"/>
    <dbReference type="OrthoDB" id="1667868at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394651" evidence="5">
        <location>
            <begin position="17"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="78"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="43969" checksum="F4C11CF6CFC224D3" modified="2011-10-19" version="1">MMKLFMVMMLVMGGWVRHWRVMANAAVSVNEGDNKEPFELLCKIYNVAQHPPIKPVDTQEYQKIVDDINALSAAANGKERVNTQTEETKSAQTQLTGITHEARKLLDGIKNVNPEGQAEMARNTFNQVIFGNNGKEDLSPGRLEVDPSRSKACGSNNQGKGRSAGKNLIVDLFCLCAKHDDEEGVDNVCGVSVGSGDGTGWQGETLLSAVTMWNEVKNGCEKFRQQSVTSTQTGHFLQREFLDKVKAGGKIKVKASGIIRQHGMLGTAVSTTGNNNLNCNGKKEVNTAGRSTSTAAGVCVFYGNHHQEENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADTQLEEEDMEESPLAQHPNSDENENADTATQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP9</accession>
    <name>F9WBP9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001608">
        <property type="protein sequence ID" value="CCD14682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52780"/>
    <dbReference type="OrthoDB" id="452233at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="525" mass="58631" checksum="B7C1CAD1F6BC5335" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBS6</accession>
    <name>F9WBS6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001623">
        <property type="protein sequence ID" value="CCD14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53030"/>
    <dbReference type="OrthoDB" id="1732252at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17296" checksum="EB9B81CC32DE81B5" modified="2011-10-19" version="1">MPEVLSFIHYHLGLDFLSLGAVSRFHTGGRDAQMKPCSPLDPRREAAATSISWKPSVDRPGPSSQPPLSFGFTKMSFFLLSIWVWVCKPRLIAYVVCVFLCSTYGAGDGVIVKKGMWFWMVMVVGVGTGTAAEEIRKNHNHHDVEDLCEVLGAAVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW1</accession>
    <name>F9WBW1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001635">
        <property type="protein sequence ID" value="CCD14748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53360"/>
    <dbReference type="OrthoDB" id="1792052at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="15494" checksum="B8E68E0D55CBCF1A" modified="2011-10-19" version="1" fragment="single">MFFPYRLLVLTLKYLRKEKKIVSNSQDIYTYICIHIHIYISFIYMSSRTYLLVLAPLCVRLFNSRIRTAVEVVYLLHLLYSFVLFFVLCCVVFRLFFVASSVLLWASHNFFFIYSPTPNCFVVCIHPLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBY1</accession>
    <name>F9WBY1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_53560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001642">
        <property type="protein sequence ID" value="CCD14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53560"/>
    <dbReference type="OrthoDB" id="1711901at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390126" evidence="2">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="23662" checksum="E06DB2B3BE794B44" modified="2011-10-19" version="1">MGMLALAGLAQLVTLRASRTVSTILSQVCDTLVARLCYWALEGVLVTFPRTKAQTVMEDGAPEVVIVEGGGVGVGGRERFPITWLLHAPHPLGRFPGMWYASGSASSSVRMSSFSSFPKRARLKALCKVVLGVGRLSKRTTDGPSTRQRAHEESDGKARGYGRGKSKGVEEGIFCIPYAFVVSYRLSQIVRTTGFRIVVEWRWSAAVPNASSQTMGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ5</accession>
    <name>F9WBZ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1845066at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="59" mass="6966" checksum="D69A575643B2D269" modified="2011-10-19" version="1">MFSFHPCLFFTFCSRRPSCVLFCLWPRAVFISFHSLFFSFLSFGSDIKPLSYTSHRSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC35</accession>
    <name>F9WC35_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_54050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001662">
        <property type="protein sequence ID" value="CCD14826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54050"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="85"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="46885" checksum="CFB3EDC555D6D3E7" modified="2011-10-19" version="1">MLLKDLIVISSFPSPFHIKINISVPIFSKHEKCKKNVRNLLIHVLTFFLRTFSSEHQRMKFKSMSMIAMVIVASGNFINSRAAEISDHNKEEKELLCDVLKATQGILSNTGHTHEKELKEAIYGSPEKNYRFGASGSVVEGKTCIFDNLRQQLCTYRSNEGCYAQSLIGAFFCLCTPGSLGRGTPSLCGATVVNYGQKGWWGQWKDGEHAELFKKVWKNVVENCTRSPDVRGSYAGRLQALGEAVKRVREKIKKNKNSGSLYSLGEGSKGECSGTSAESVCAAYTHRQTKDSELDIPWADTIESILKKLRLNAQDRQIVDPRQPEKPSGVEDTNSIKHEVSQPSTSENKGKTQEGDKKDKETQTQTKIVGRLSTSEGEQARKRRRTPTSDKTSIESLATGVAKDGYFLKKPNWLLVGTLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC56</accession>
    <name>F9WC56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2188</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001672">
        <property type="protein sequence ID" value="CCD14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54250"/>
    <dbReference type="OrthoDB" id="1248226at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="254" mass="28873" checksum="717E9CE4401036D6" modified="2011-10-19" version="1" fragment="single">MEGYKDILLSQPPAMYQRVPQMSNVTLENYKGILLCACPTNVPPGRSTELRGGDGAVTNGTVFVPAGGCKEPLGLGPSTEHRALMERNHRQRIQNTRNQRAHLSAVVQQHRRWLRSFAEQIRNMKKEEVEREVERARRVRSTRRKWTQRVAESNDKTPQETREPADVVRGEPEEQRRGNADNCRGSSPSAKEAKDKPKVGKKKKKPKWALTEDEALEDKSPRLMICLNLRKTLITNSLSTNNEWAGDLSVMQKX</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCH6</accession>
    <name>F9WCH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001724">
        <property type="protein sequence ID" value="CCD14969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14562" checksum="B76C2BAE49F1A6C5" modified="2011-10-19" version="1">MVCGMAGTHSLTCSVISAKHNERKYHRSSASFPLHGHVQGPLPPHTSECRKAIAFTHWVTHVPLKHTTTHFIPSLPLTHGLTLPSLHWPWRVLRSLQSLPLARLSNYNKREMASRPPVTAAHPLGPIAASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT4</accession>
    <name>F9WCT4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2263</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001757">
        <property type="protein sequence ID" value="CCD15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56450"/>
    <dbReference type="OMA" id="EAQHSLM"/>
    <dbReference type="OrthoDB" id="1347320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="328"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="492" mass="54273" checksum="40BACB4B99029A51" modified="2011-10-19" version="1">MSGSGTQVVMNDSRSQRQPQQRMHQSRTQSIDSANGVASTGSVTTAEVAYSTNSNTNTPSSNNNISSNNPSGCTSDRPGTCGSELCLREHLRLTEELNRTLTAYAELEARSHFAQTLWELSAAREAQHSLMLVAENDRLRGQVNHWRAVAEDTTGQLEAANAQLRNCRDDLHETQQSLQASIASAAAAITAERKEAEEAIAVLKAGHAAELSQVRLQLEQALDDNIRSREVLQKTLESSQKSAEAQRAQLESDAAVAEQRAAGALQAKYEIEVALAEMAAQRSSEREGFERELLILQSANRRCVEEKTKQASELRLLRESYSSVEVHLHEVEAELEQVSGQLRGALDKVMQSAKLEDELEITRTRVAVAEKELGEQREHYEEKIRLQLEAFAKLQRERDADVLRLERDIQRLRRRCESGKIKLAAVLKGMAGADRQPCQTHIQATIGSDGRSENGCGVVEEPLRCDAVALLKQSTAVACMLSSTIRRGITQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD16</accession>
    <name>F9WD16_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001802">
        <property type="protein sequence ID" value="CCD15164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57150"/>
    <dbReference type="OrthoDB" id="1729066at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18134" checksum="88D687369F6B228B" modified="2011-10-19" version="1">MEGGGVKRTRDEMEREAVAPVEQAEAPARDQVTAATVGAVRPVAVRHEVVAGASGRWTLDSSVEDVLMERCGGVSDVSLHDFLMKHFGETFGSPSVSMRVFMGNPSIFLRDEPLCTLVTDSEPYREYVEEYGMYKTMREGVERLRAMKLFLFTSGKVPLPLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD68</accession>
    <name>F9WD68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001830">
        <property type="protein sequence ID" value="CCD15219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57630"/>
    <dbReference type="OMA" id="AELWLQC"/>
    <dbReference type="OrthoDB" id="473016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="451"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="602"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="750" mass="82519" checksum="2344D85B72BF6FD5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDZ6</accession>
    <name>F9WDZ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001933">
        <property type="protein sequence ID" value="CCD15501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06230"/>
    <dbReference type="OrthoDB" id="1709709at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21430" checksum="9C191F6EA556AD4F" modified="2011-10-19" version="1">MSPVRQSYFRPIHTSPSISLCPTLTAASQVVAADGRLCNAPRQMVRGSHISLAGLKLTHIIEHSARLPKAFPFTTSGTFNGSRIYTHIRSHQDATCAPMDAATRSHAFASRRHHRLPTHHMPQPPERLIGAHQTHERHDVEPYAQSGATLLISNGAHRAQISHFHFPLPDKANSPRTNTARHDHEEKQWEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE51</accession>
    <name>F9WE51_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001953">
        <property type="protein sequence ID" value="CCD15557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60490"/>
    <dbReference type="OrthoDB" id="1706182at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="21942" checksum="8BA24E3658CFBD5F" modified="2011-10-19" version="1">MLNDCSDKIVRIISTKSPVSLPCGCVTGKGDDPKMCAFVVSFFWKCLCLGSASNARGSTSMNQKEEEKLYDINESSHRMQYYVQTPKSHKRVTQRNRKKLSSCTLQWVTCQEREEKKKLRLTEAAYAPPKVNTKKQCKTPADVLLCASGIAKGVGNARLEKNMKVFFTLASLSSDDSPYSCFICHFFYRYPCCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE93</accession>
    <name>F9WE93_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_60850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60850"/>
    <dbReference type="OMA" id="DVKFQEN"/>
    <dbReference type="OrthoDB" id="1727325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394933" evidence="1">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="26498" checksum="BBBD00E62EC7246F" modified="2011-10-19" version="1">MTTTMSRVLHLMTVTLLCARVGMGQASDDDDCGGQSIPQKVEGVQTMCDVARQLRALETASQSAVAAVVSSAREASEAKERAEKAVERAKSKKRGVDTATEAAARAAAAAQRAETVVSDARKHAADLTAASKDAIETTDESLRLLATCEKADEPIRTAAKKCTGAAAEVTSKSLESAFDALAELLPDGADDIREHGAVFVKGLKSLEDDVRTAGEAKSEAEKAEGDANDAADGARAVLTGVCVLLLLAALHFSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEA1</accession>
    <name>F9WEA1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001964">
        <property type="protein sequence ID" value="CCD15607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60930"/>
    <dbReference type="OrthoDB" id="777540at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19083" checksum="4970490CB26CD63B" modified="2011-10-19" version="1">MQVTSAVRKRENGEKATAVFIDYERAFDSVDHGCVIEALKPFGVDVHFVARITRFLQGRAGQVRVSSIKSEDTQITCGVPQGSVLGPLLLLITVVDSLSKRLNEIPGFMHGFFGDDLTIICIHTKLCWRFKKRRRRAWIASPVGQRSSLWRPQRRGRSTRCLDPVTKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN5</accession>
    <name>F9WEN5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002043">
        <property type="protein sequence ID" value="CCD15746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07570"/>
    <dbReference type="OrthoDB" id="1662834at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="451" mass="50006" checksum="04CE06D827C92B3E" modified="2011-10-19" version="1">MCWFRLFCSQGTSSGDVATDIIDRDPRWLHGIMFLLGSAKNINQSHVSGVIIEARENMRMVKEQMDNEVCEMERFLENLGDLHGFSEWKNSWRVVTRAVKFGTVSMFDVAEEEVERCLCEQKETTKAIQVAVCGLRESFEASRSNDDFGSIGVSIGAAASSDNQSSDNGFTACVDISGYVKHYKCLGATLKEALDMKGKSTRGVNGDDRITGSALKTMVREAADHTTQLADSLALLQGFRVGVVTYLSVIWTLFAHLEDIAVSNGDGERTQLDRTQGDPTGMTGATLRTLTRNLPIYVARESLRRRVRLDWDWYRPPADILIVLLGCIFSVFSGPVHTSYGSTEPYCYIAVAAVIITSILILAGWPLVPLCTPYLKGLWRRMRGRQHKPRGVSEATCPVDGERYETFMREYGGGSVRGQQQMPDDPGLSHGAQQEARGTRMLFDPSVNKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEP8</accession>
    <name>F9WEP8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_07710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002048">
        <property type="protein sequence ID" value="CCD15760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07710"/>
    <dbReference type="OrthoDB" id="1673542at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394955" evidence="10">
        <location>
            <begin position="27"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="16"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD15760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="43206" checksum="56FFB3D8E02D8B95" modified="2011-10-19" version="1">MFMELRSTWWLFLAAVILSLQNTVWGNSQKAIPTKAGAAICTLSKTLKDVTPWATQQVEDGAAKITHLEMKLLEWQSKFIQSKSKGGGSEECKVTGLLFRQVRKEINKARAEVEKLEKEASKAAAFAANSAGRLDEFITVFANAKGSDKYCLGDEKAATPEDLRDCFSKNDFSEESLVDIGDRASVKEPNLVSDIEGIKHSKLSSHFTGTSSTTEAGCNLIKGTKKGILENTELEKSLWWGGGILTIGKDFAGDLASGGSLIAGEITAATKDKATWTADPAKQIVHIKNASDAFKAFKAVQETIQAKVESIEQKIQACIGGQESGENSTEQNTTEQTATEQKTTSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSALNPRKATRHFSILLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WES0</accession>
    <name>F9WES0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 308</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002057">
        <property type="protein sequence ID" value="CCD15786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="887067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19334" checksum="E7C0CBA76B7E2DAA" modified="2011-10-19" version="1" fragment="single">MIRQNLDVVPVVQPKHRLEEDARLAAEKRQRSLAGSSAAAAQPQVVRYIISNSDKTTGEEPEEPNKRNGLRLFALDSTFPSDDSRSLRTLHVLDASRGTWRHVTRSVYRGVLFSRHSTEKPDDSDDDGEDYRFSSLPLPGYENKSCFLLALPPATDGDVGVAQARPLNVPIHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WET6</accession>
    <name>F9WET6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_00840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002062">
        <property type="protein sequence ID" value="CCD15802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00840"/>
    <dbReference type="OMA" id="CELPPDA"/>
    <dbReference type="OrthoDB" id="1082831at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="192"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="453"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="953" mass="107028" checksum="D895FD9809F544A7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEX7</accession>
    <name>F9WEX7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002075">
        <property type="protein sequence ID" value="CCD15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08400"/>
    <dbReference type="OMA" id="HPFIVIS"/>
    <dbReference type="OrthoDB" id="1666504at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45502" checksum="1048D74C4A4E8A5C" modified="2011-10-19" version="1" fragment="single">MEGRGVRRTRDEMEGEAVAPVVQTPLRGEVATRTVSAVRPAAVRHDVSERPSGRWTLDSPVEDVLMEDCGGLDGMRLHDFLMKYFKRTFGVEDTSMCVFMDDPSLCVSDESVLRWITNSSPYREFVEDYEIYKTMREGVDRLSARGIFSLLQWARAEAANEVRDVNACVRGMLNAAILSVRRYEEATRYVNAHSVKVIDGVYDSVFNARWSYVVRSDEYGEGTLGMGVLRVSEGEQPHLWSEAQADIKPEPDPDEPWEGDVVPGVEEGEQPSLLSEEQADVPYDPEEPWEGDEVPGVGGKLVMATLKSQKGWPYMLFNANKTQEKGAESLTEYNAVCDAYIRRENLRVWHIVKKGLDEWLNGVKEVHPFIVISTPGIGKSFATGSVLLYQMLHYKSEDLKVVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ7</accession>
    <name>F9WEZ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_08600</name>
        <name evidence="3" type="ORF">TCIL3000_0_57400</name>
        <name evidence="2" type="ORF">TCIL3000_5_5320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001820">
        <property type="protein sequence ID" value="CCD15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002083">
        <property type="protein sequence ID" value="CCD15863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC90767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16581" checksum="3889D8849174899D" modified="2011-10-19" version="1">MGESDHPDEERMHHLFKEEVQKCADEVVEALEIFAQDDPQSEGARDGKRDDFSKTASDIMGKCGAIIGGLQWGEEEGAVGEEAIGRTKKCLEEIQRLLEDFCRLASEEYGNRGKEVSAVVHEIIKKIGENLSRAKKNKRLRCCGRTGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF68</accession>
    <name>F9WF68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 354</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09220"/>
    <dbReference type="OMA" id="VEDASMC"/>
    <dbReference type="OrthoDB" id="1663926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="487" mass="54629" checksum="34D3D48DBF1EEA35" modified="2011-10-19" version="1">MARKRGRRTRDETEGEAVAPVVQAAARGEVTAATVAAVRPVAVRREVVTVPSSGWTLDNLVEDVLMEGSGGLNDIGLHDFLMKYFKRTFGVEDASMCVFMGNPSFFLRDESSLALVTNSSPYREYETMREGVDRLRAKGMYFLHQWEGAVSATEVEDVNACVRGKLNAALLSARRNEEAMRNANAASAVELDGAYDAVFNARWSYVVRSDEYDGKWLGMGVVDVAPGEQPQLWSKEQADVEPVVWEPWDGDEVPDVSGNLVMAVLSSQKGWPYGFFQRDDVREEKVDRLTGYDAACDAYIRRENVRVWHIVEKNIDEWSSGVGYVHPFIVIGTPGIGNSFATGSLLLYQLLHHPSEKPKVVAYFVRGEAYLFHREERRVVRYAEEGIARCEVEGMARRGVKGYMIYDNSDNGIDISVGSCSSSWGIVLISPPNVKVFHEFTKQLQHTLPIYINCYEDVELKAVLVWERQSQLENNQIKLENTNLGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFF7</accession>
    <name>F9WFF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002139">
        <property type="protein sequence ID" value="CCD16025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09960"/>
    <dbReference type="OrthoDB" id="1734426at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="25279" checksum="50529D167A5F99BD" modified="2011-10-19" version="1">MFVTRCDVLPCGEGGGAFFFFSRGIKVIWRVCVEGKAKCDEGVEEEEEGRRLKLIQKRGREKQGSEVASVQRSYSLSLACFFFFEIRLLIHSNCFCSHSRRILFFCSSKISPSLKKLHYLPLPPPFECPLPPIRSREACRRSAMKLPHASFQISFSPHFPSRSPHRGWIRLSLAMRAPCLSFLQLISFLFFFSFFLAFPPPYASFIDSFFFFFFFPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN7</accession>
    <name>F9WFN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002169">
        <property type="protein sequence ID" value="CCD16114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10710"/>
    <dbReference type="OrthoDB" id="1703862at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="20807" checksum="448FA8632710B458" modified="2011-10-19" version="1">MESCCYGVCKRGFDKRRHLVTFPVGYPFIIKLTTKQVEFRTIFENPPCYAAVLKALAGFATGNQISFSRYACTLWKANDGCLAYSLDQPFIIWLFPQQPTRLHGSTELILPPKSLSRNGACPPKRIKAHLCVESGILHILLAIGVRDINSHHSGWQTFHLLLYLKTEWMLDLCAAVRAQRLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFS4</accession>
    <name>F9WFS4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11030"/>
    <dbReference type="OrthoDB" id="1733614at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17378" checksum="8834C54F25FD3476" modified="2011-10-19" version="1">MNSSKRPAEWAAKEAVLQASFSSFFTSFLVLSISFRTRLNRRSVILHAFEKLPLDLDWMNLDCHSSNFISMCVTFAAPSSTCCVAQGVTSFKVLLNVHMASPPLVWMAWGPVPKMSSASRINTEEVRSRHHLERNSITLSVNRYPILLVTLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU4</accession>
    <name>F9WFU4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11240"/>
    <dbReference type="OrthoDB" id="1721117at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18685" checksum="C92A5D299DAD4154" modified="2011-10-19" version="1">MFVRMTCCLSMVIRASIRARGTYGKQIKQKVAAYDGRFHCINASFGQTHCGALHWQQQLDWQLCLWGITKWMGSCEWDGNMTAVRATFVAAAWIFVSLFGGTVSVDEASAREAIGSQRDETPHNAITKGATQRECTPTDRGRCNKWKESADHKGSVLYWNGLDFLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG32</accession>
    <name>F9WG32_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 460</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002225">
        <property type="protein sequence ID" value="CCD16262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12100"/>
    <dbReference type="OMA" id="AREQNIC"/>
    <dbReference type="OrthoDB" id="1345899at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="2">
        <location>
            <begin position="111"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="520" mass="55759" checksum="02D1C032F665C445" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG42</accession>
    <name>F9WG42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_12220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002228">
        <property type="protein sequence ID" value="CCD16273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12220"/>
    <dbReference type="OrthoDB" id="1665897at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389094" evidence="5">
        <location>
            <begin position="25"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="88"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="436" mass="48101" checksum="0D9AD6897005C3C8" modified="2011-10-19" version="1">MENMVWFMTVIVVVVFTILEGVRGQQNNAQVQQVDNAEQFALLCRIYNVAKNPPIHHVDLQDPSKIVSEINAINASFTEDKRLNETEKAENGTDVELKHTTTREASVAQAILSRITQKAQNILDEIRKVNTTMDIEKTKTEFAQVIYGEGRNESHVCDGELNAVSNRASACGTSELSSRGDSAGKNLVIDFFCLCAMTTDDNGVENVCGVYVGGKGGKTHKPDSHGWDSKGPLGSSSMWASVKKGCGKLTHQHPMSTEEGQDVIENFLIHLKAGGLYRWGETNRIKGRDRKPGMLGTGVGTEGDHGKSLVCDGSRGKSGQQLQRSGGKTVNPAGICVYYGTESEWENIPWMMKLKSALANVEHVNNKKATIQRDIDKLEKLLHRAEEIYETTKVITEIQKPVVPPNLQTAAKRLTAYNAAQRHHPNTHFFSLFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGQ6</accession>
    <name>F9WGQ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002304">
        <property type="protein sequence ID" value="CCD16493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16132" checksum="9F59CE99A832E60E" modified="2011-10-19" version="1" fragment="single">MSCAYETFLVARPIIAILGPKWVYVIPWFPRSFDQAGTANAAVTLVLTDIVVRVSPRTLRSITDLLLPKISPCAGQGIPQRRTPCDSAAMEHRNAPEGAHRAHDGRLSCVDNHGPYWAAWISSVDGINQTNHSTDQKRPCTTIQGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH39</accession>
    <name>F9WH39_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 589</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002369">
        <property type="protein sequence ID" value="CCD16628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15370"/>
    <dbReference type="OMA" id="ARNDSFG"/>
    <dbReference type="OrthoDB" id="1346836at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="570" mass="63237" checksum="F086CC93DE7679F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI0</accession>
    <name>F9WHI0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002438">
        <property type="protein sequence ID" value="CCD16773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16740"/>
    <dbReference type="OrthoDB" id="1692334at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="24794" checksum="B524E535675EDF5E" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMCVIFSXPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFIFFHVIFSFPSPGALQNCFCNNYFVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHLARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHK7</accession>
    <name>F9WHK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002451">
        <property type="protein sequence ID" value="CCD16800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17000"/>
    <dbReference type="OMA" id="AMLYGRM"/>
    <dbReference type="OrthoDB" id="783386at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028784">
        <property type="entry name" value="BBS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032728">
        <property type="entry name" value="BBS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20870">
        <property type="entry name" value="PTHR20870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14779">
        <property type="entry name" value="BBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBS1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="598" mass="65170" checksum="ABAB354B5A1A35AC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHM5</accession>
    <name>F9WHM5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_17170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002461">
        <property type="protein sequence ID" value="CCD16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17170"/>
    <dbReference type="OrthoDB" id="1674355at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390348" evidence="5">
        <location>
            <begin position="18"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="45"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="39785" checksum="BB2D90703C7AB462" modified="2011-10-19" version="1">MKVLSMMMFMCVIGVNGDMDDHNKDAHRRLCDVLRASVYKWEDVKKRDDDDPLRKALGRTLFGNDGRMDLESIRTFSAVYRGDEDRDLFCGQRHAGYNKEKQLRWPGYSGPHDLLCLCTPGENGWPLKSSNDDRAKNKLCGQEKGTSASENEGWSKNKENKKGEKQMKATWDGVVQECLKDDGHKRNLQDALKVFTEKLEHKSGDVTNPDRYQLGEGTPNNWLACTGKPPYGVCVLYYNSTKQNEDMPWWKDLEDAIKIEQARQEQKKLEDKKQKQEETEKKKKGKNQKQSQLPQETRANALKSTKTATEEAEQDNTQNISTPIATTEETSGTLITTPCSWLLSALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHT9</accession>
    <name>F9WHT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 694</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_17680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002485">
        <property type="protein sequence ID" value="CCD16884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17680"/>
    <dbReference type="OMA" id="AILLYNC"/>
    <dbReference type="OrthoDB" id="674800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="236"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="447" mass="49472" checksum="BAD5E63C43B35212" modified="2011-10-19" version="1">MALGFSSAAEVYVYVTCIFLGMSILLPLNTRYSAPMFMINYYKYVTGDEDAEPNSKLFWANILTFYGAISLVIQSLVGPTVLTQAARRLSLSVRFTLSITSMMIEVFVVLMMPVIKVSQTTAIVFFVIVTIVGGIGKCYLEATCYTLVAPLPPKFMSTIMFGICFCGVVTSTIQCIIKASMEDTYESHLTQSYIYFSLALLFMAAALVMALSLRYNSYAQEMVAEYRVLKQKQEGQKVEPQPVADVPKEVKEPTDGEEDPQNKEENKGEGEVGMTTAEQLAATAVMPVVKMIHMMLLSCFLGFFVTIFIFPNLIIPIDRTHKWFATIAALIFNIGKSIGSFSTSFKMFMYPRGVVLYGSIVRFLLIIPFMLSIYKHIPGHTVPYIFSFILGLTHYFPVLSMVYGPTTPGLDDGQKLMAGQLMGIALLVGVSAASVVAMIVVIFLPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHU0</accession>
    <name>F9WHU0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 69</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002486">
        <property type="protein sequence ID" value="CCD16885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01950"/>
    <dbReference type="OMA" id="YCYPYCY"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038787">
        <property type="entry name" value="SRRM5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39414">
        <property type="entry name" value="PTHR39414"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="775" mass="102723" checksum="2D08FF1FAFD21337" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHU4</accession>
    <name>F9WHU4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17720"/>
    <dbReference type="OrthoDB" id="1727916at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17809" checksum="3EB7961DC1D5E445" modified="2011-10-19" version="1">MPNHLFMPPLTLSCENILRVGGCQQWKQKHLFICPGEQAQTNRTKAVLLIPSESHIIRKSFPGVVCVPVSLPTVPMHPRTLFGVFRFFLSSFFFVQLRCVCPPGTRTKRNKILQYSRFSTPFLMGLRGVIPPRFVPAHSFTPQRPEEIPRHIPSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHV1</accession>
    <name>F9WHV1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17790"/>
    <dbReference type="OMA" id="REYRVHH"/>
    <dbReference type="OrthoDB" id="523836at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PTHR23270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
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    </dbReference>
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        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="672" mass="74156" checksum="C44C2D2F05B4025A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHZ3</accession>
    <name>F9WHZ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 710</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002503">
        <property type="protein sequence ID" value="CCD16938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18200"/>
    <dbReference type="OMA" id="CHIRSKG"/>
    <dbReference type="OrthoDB" id="1536091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="553" mass="62033" checksum="496BF24726652543" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI34</accession>
    <name>F9WI34_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 726</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TCIL3000_0_18480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002522">
        <property type="protein sequence ID" value="CCD16979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18480"/>
    <dbReference type="OrthoDB" id="1710127at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21157" checksum="37AB27E78DB084D2" modified="2011-10-19" version="1">MSWYTITSPRTIPWSMEKDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAVWQYLPYLLWKFRQSATPLVKHFGPTQTWKKWHWDSWKIYYDNDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVLVGATASFVQVPYSTVGYLVPIPLSPGSWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI47</accession>
    <name>F9WI47_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_18610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002527">
        <property type="protein sequence ID" value="CCD16992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18610"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="499"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1106" mass="122936" checksum="71462A883044A7C4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI69</accession>
    <name>F9WI69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 736</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002533">
        <property type="protein sequence ID" value="CCD17014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18760"/>
    <dbReference type="OMA" id="YLEYIGP"/>
    <dbReference type="OrthoDB" id="1666511at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="22034" checksum="AAAF62E21E1982ED" modified="2011-10-19" version="1">MEWNVVKPMPKENGKICQDTDDHTNHSCTVWEGWVADYKKTTDLMKKLGGAERRARRARLQGEVEVIGLYKIYQALRAGEESDVIELLLEEAEEKRMLANEAELVSGVLVTRGSDKMSLERDKDLKLLKQARTETPKGMSWTMVAMISSLPVGLALMVYIISRFRKMPENGKDDLISPTCSCSLTNVGVEGDLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF0</accession>
    <name>F9WIF0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 780</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_19490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002581">
        <property type="protein sequence ID" value="CCD17097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19490"/>
    <dbReference type="OMA" id="ANPSTHE"/>
    <dbReference type="OrthoDB" id="1289550at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_S7e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="PTHR11278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="319" mass="37332" checksum="BD8E7AE67E0DF587" modified="2011-10-19" version="1">MTINLPILIKKILNDFIGFRIFLYLFSSYFNLRTVSILRYCTTNLYQRKFNDIVKHVSLFSGTVVSSTDCLPAALVWHVRRCTNDDIFLLSAVLRFFPFLTYSSPVSDGRHFCTLRAMSAQPHLRKLRKLKRANPSTHEDNVAKALFDLEGSHKTLRAQLPRFHINTVRTTTIPRSKKSAMIILYPLRFIMLVRKIQRTLTSELEKRFPGNVVVLVAQRKITKRPTDVYKLQQVQRSRTSVAVFENILNDLIYPCDVVGRRWRYRTDGSKVMKVFLDARDRKRVESRLPLIAHVYKQLTHRPVNFGFMWNPKLQQVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIV3</accession>
    <name>F9WIV3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_20850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20850"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395090" evidence="5">
        <location>
            <begin position="18"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="34"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38204" checksum="133A373961E4C468" modified="2011-10-19" version="1">MIMWKVALVMIVTEVSGNGAKHNEEHHGTLCEVLKAVTAKWGEVKERDSSDPLKKALHKTIFGNMSATEKVSELKFPKDYYPSVTEEKVEPNSRKYWCGLCGRPGQKHYPGESATHDLVCLCTPGEFGHPVNGGGEKKLCGQSQGTWGADKKGWHTELFNDNEKERKHLSETWNKIIKDCLQSGNGDDLDTALKKFTDKLRSLNGNQYLGDHSDTSDCSGTAYGGVCVKYPLECVKNSWWKELEKATRKAKENRQNKDKEKIISESSEKGQKWKTLKGQQKTSEKTVQTPQPTPGVALLPKTEEAHNPQTVEKLLANISATHDENSSPIIKPHWFLMAALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ8</accession>
    <name>F9WIZ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002667">
        <property type="protein sequence ID" value="CCD17299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21270"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20165" checksum="5D4C6697F418DEB6" modified="2011-10-19" version="1">MSESPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPKKINLYRFLQPAYPFIHSYVSRFSIIDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQTRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ81</accession>
    <name>F9WJ81_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_22080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002694">
        <property type="protein sequence ID" value="CCD17385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22080"/>
    <dbReference type="OMA" id="EHYLGRE"/>
    <dbReference type="OrthoDB" id="1667222at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390480" evidence="3">
        <location>
            <begin position="26"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="46495" checksum="169D63EEC5C4DD1A" modified="2011-10-19" version="1">MRVYGLVFVCLSWLALLSCVASSSSDNNGVCMLQGDAAAVLCAIAHLVEKARSIAHNYDLKGAEDALDYVKLHKDQLDHRKTRLEELLEEAKTKGTLTPEQADKLKGAAGEAQKKNDEEHKRATEVMANYTAHHDKTKNVTTTARGETLTRQVCLSTASLIDILQCHVQGKIPDRSEGNIETICRDKGYEKHISEPLKNNLESCKGIGGSKKYCNGTGAALKEALEKWGRQGNNNGGDSRNIGNCKVKNHWEKHAHEAKDHMLTLDHILETVHSAKELTTAYLSTVDKMKDGVEKGKPMKEILEDARNAGKEGAVVLVAKPHPSTGENATAASETGGSDKVEEEVKVNVKLDGLQFDEDESSLANSKDKFPKYYVYLLAVLVPVCSIALAVAIFCIIRRTRPAHAEKGIPVEGAAAGKLQDGGKTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJU7</accession>
    <name>F9WJU7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002774">
        <property type="protein sequence ID" value="CCD17605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="EMNCEEL"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15538" checksum="A96ADC82C9272078" modified="2011-10-19" version="1">MYAKRPTNVPDAPPMELPSTGNVPFRPLSKHGLHLGMPELSSNTAAGEDWISREELQPFNRCLKRVPIPKEWFSDIVVPLLKPVKPALDMTSFRPVTLTSTMCKCIEGVVVKEPLHASVSWETEYKLLHSEQSGSGITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJV6</accession>
    <name>F9WJV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002777">
        <property type="protein sequence ID" value="CCD17614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14855" checksum="C32F34ECAF696403" modified="2011-10-19" version="1">MCSFVSFLLPSVQLVPERQNSLRLPPLLGFLLLLQLSSRKPNRCVPSDCWKDRNENNNNNKWLSATAAPHSGKGPLSLTNKDLLTVCFLNAVALSGAVLFRFKALFFLVVVVVCLFAFLFSSLELLPTLLECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX7</accession>
    <name>F9WJX7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 964</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HYEMNIN"/>
    <dbReference type="OrthoDB" id="8207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="2166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2166" mass="241700" checksum="50420DA0A5FC138B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK57</accession>
    <name>F9WK57_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002812">
        <property type="protein sequence ID" value="CCD17718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25020"/>
    <dbReference type="OMA" id="VKMRCMG"/>
    <dbReference type="OrthoDB" id="1418044at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="297" mass="32811" checksum="4B11B660AAAB42A9" modified="2011-10-19" version="1">MSTMARRAIFWCAPSRLPNCAGCCFVPRVPLARHICCVRPGTFNFAVSPLTAQLRLISAESKDGAVSLGQTEPPKSDGGDGRAESQQSALNDLLEEVQALLSRPVPIGSLFQALSAESKKTLVKNKLPLEQLLLQHPRHFALYQQGNVRNRTIYCAPAHLMPANARPMIIASSPFAPPAASGFGASTSTSPSGSGEPCSRKVDDINARVLQHDPLLEKQQRINTVLQYIPNEWSPFADLGIPEEVRVKCMGKPAVKALQFFEKYPQYFEVRQQGRTEHTFQVRRSVALQRSQDFRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK74</accession>
    <name>F9WK74_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 995</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002819">
        <property type="protein sequence ID" value="CCD17735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25190"/>
    <dbReference type="OrthoDB" id="1659231at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="649"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="829" mass="96695" checksum="3EF991284AA7224C" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK86</accession>
    <name>F9WK86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002823">
        <property type="protein sequence ID" value="CCD17748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14493" checksum="50A656588864E681" modified="2011-10-19" version="1">MVWLASSYSRSLYCCAWMAVLINFSALPRSYRLFVLFSAKNRRISATDWSMCFLFISTSWYPPFVLFQISIAPLPSTFSSRFFMSHNFPRVSGLSLHTRSPVCSPSACLPNNTTTTTTTTAKTQPRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W366</accession>
    <name>F9W366_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1007</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000360">
        <property type="protein sequence ID" value="CCD11574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25450"/>
    <dbReference type="OMA" id="METHRIF"/>
    <dbReference type="OrthoDB" id="171907at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Vid30/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="2">
        <location>
            <begin position="1809"/>
            <end position="1989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1499"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1519"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="2130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2130" mass="237283" checksum="0AA1E0928BA9FBFE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F4</accession>
    <name>F9W3F4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000403">
        <property type="protein sequence ID" value="CCD11667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02880"/>
    <dbReference type="OrthoDB" id="1715010at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17480" checksum="CCB124D017519DB3" modified="2011-10-19" version="1">MWNSCDKYFPPLLLNILRPHVVRSGLSSCIASGDEGTPPWVFLFCTPPRTAGYAALPHARDPLKQLRVWTRVARHIATYEWPALQPCRLQLQYAPLLPVQNPWCQHPLHESYGVPTLPWALAFPHHLIQPRKFSFPNASRVCGRALPYVLYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L5</accession>
    <name>F9W3L5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_26890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000433">
        <property type="protein sequence ID" value="CCD11736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26890"/>
    <dbReference type="OrthoDB" id="1680940at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="31592" checksum="B1B3412559F69E36" modified="2011-10-19" version="1">MAGGIGGRGTAFAEGFRDGDGVTSLTAAEMAGGIGGRGTAFTEGFRDGDGVTSLTAAEMAGGIGGRGTAFAEGFRDGDGVPSLTAAEMPGGIGGRGTAFTEGFRDGDGVPSLTAAEMAGGIGGRGTAFAEGFRDGDGVTSPTAAEMAGGIGGRGTAFAEGFRDGDGVTSPTAAEMAGGIGGRGTAFTEGFRDGDGVPSLTAAEMAGGIGGRGTAFAEGFRDGDGVPFGRVADVCCFYGCSCVVPDICNFRSVFDASFGLISDMFILLWRVVVLLILVVVFWDLLCIALIIFLGWRRMSVVFYWXKKENVLSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W435</accession>
    <name>F9W435_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000509">
        <property type="protein sequence ID" value="CCD11918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14034" checksum="2A8909A7AF9E25E0" modified="2011-10-19" version="1">MSSAPSRDASMPLENPWLRAVSTSIRAGGGIILVDINPPISFPSSYLSMPFITLPTLVCSETCPSLSLSSSDTPASSPSSALFPLKLFRRYLPKSGAGHIAIADFNTLVNEEIVILNHRDAMVKNSEEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4B2</accession>
    <name>F9W4B2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_11890</name>
        <name evidence="7" type="ORF">TCIL3000_0_29260</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000536">
        <property type="protein sequence ID" value="CCD12001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002212">
        <property type="protein sequence ID" value="CCD16241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29260"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007659397" evidence="5">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37051" checksum="E00E130CAFC092DC" modified="2011-10-19" version="1">MVKYLMVMMVAVGVCASSDEKNHNGEEHLALCSVLSAAVTIFQSGRGGPTLQKALRRALFGKENGVGDISTLLAELPRTHHNPESRKSWCGECRYYGDPYPGWSIPHDLLCLCTVGENGHPFNSYGSVSQLCGRSVTELGCDHGQRDECHTGQGKGWSTSSTGESARRHVEATWESVVKTCLKKGLNLTVEEARKTLGEKLTVEEHRSAAWERSHYYCGGDFSGGGICVSYNLCGKNGYLKQPHWLEDVYDALLTANFNLPPSYLNTTGFSNTTFDEGEDGDERGPNGDSHNGTHHGSSSTRRRRKRSNHAVSHLFKEDGTLLTHPLLWILSAAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4I6</accession>
    <name>F9W4I6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000560">
        <property type="protein sequence ID" value="CCD12080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29990"/>
    <dbReference type="OrthoDB" id="1422669at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007710">
        <property type="entry name" value="Nucleoside_deoxyribTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05014">
        <property type="entry name" value="Nuc_deoxyrib_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17079" checksum="BB86DF11B147C645" modified="2011-10-19" version="1">MKKIYIAGPAVFNPDMGAAYYDRVRRLLQEENVVALIPVDNPSTSALEIRKNNIEMIQQCDAVIADLSPFRGHEPDCGTSFEVGYAAALNKLVLTFTSDRRPMQEKYGGKVDKDNLMVEGFGLPFNLMLYDGVEVFHSFEAAFAYFLAIAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Q2</accession>
    <name>F9W4Q2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000591">
        <property type="protein sequence ID" value="CCD12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="15987" checksum="5D9B6AD92994D218" modified="2011-10-19" version="1">MRVWLYFVSYRRCIWHQQSVLHSSEYQQILLASTRHTVAGPRPGCEGKRGTDRRTVRNERKQPWHFLTPWCYQPCPANFPQNAGASSLALNRLAEAAGPLAAGADVSSHHVMRNPLHPSDTAGECIVKWCIQKGNKLRAPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4T2</accession>
    <name>F9W4T2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000602">
        <property type="protein sequence ID" value="CCD12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30860"/>
    <dbReference type="OrthoDB" id="1731218at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="17849" checksum="A0A0E64F28C636CD" modified="2011-10-19" version="1">MRHISWRVLSPKEAGGRKARAPRRVGAPSQIPPDMRSNTAHGSFEKHAHVSSEIHTLPPTDTHGGDLPLASFTPAVAAHNACQPAFPKTSARVSRVRSSGAAFSPNTITGGQALTSRECGRHCPEAYSSSNTSPAISPSPRRLARRHGGSTHGTLASEFAFNQLNSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W595</accession>
    <name>F9W595_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_03310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000683">
        <property type="protein sequence ID" value="CCD12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03310"/>
    <dbReference type="OMA" id="IKIFVAP"/>
    <dbReference type="OrthoDB" id="600467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="PTHR17408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="SLBP_RNA_bind" evidence="4">
        <location>
            <begin position="43"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="47926" checksum="5B3434EDE35F4A8D" modified="2011-10-19" version="1">MQTPLRPTIGPESIDGSQSASSFRKPTGERALVGRSNRWSADQERRRLQREKQLSFGYATDGYRNMVKLVEHDPLLRSGGVIPLLPPDIDKGSKRLWDVSLRKWRRALHMFDCVFIDGESNEGKTLEDIVEEQRQQWVSKPFTNEKKENRVRVPVEAFHDARNSPHVCTKLHVEECLKVILRDESCYEPVCNVVPTCASSLLKGSDVTPADAGIKIFVAPSPSNAFGNAAGRSAAVYNQVSPQCLNFDMVTPLKNKVPVSGVHKVQPFQVHAQPQHKENTNMWLAPTIWMDDGMCGSPYTTIYQPLIEHITDFQQTPLNPNLVIAPQLYVAPSSPADFPGPIFDKFTPATAPRRLTFLKSSSSKISGGEVDTPKRNLFPNNAMSPCHVDPSGRACSLSMQVNGTCVRRKSTEIETIGQVDSNCAQQIVFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L8</accession>
    <name>F9W5L8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1340</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000730">
        <property type="protein sequence ID" value="CCD12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33470"/>
    <dbReference type="OMA" id="GKPCTFG"/>
    <dbReference type="OrthoDB" id="1040147at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113236" checksum="3B9AD29890DCA389" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5M4</accession>
    <name>F9W5M4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1345</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000735">
        <property type="protein sequence ID" value="CCD12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33530"/>
    <dbReference type="OrthoDB" id="1771117at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16079" checksum="7A4CD53F5411224C" modified="2011-10-19" version="1">MAIFGGGIFPGVDPPNGSMQGPPPQFGAKPQNPPRGNNPRGPNKFRAAKRLPTKPKKKTVPEQNGKKNPQVTAPKAQPPQGGPGGKACRKRRKPGRGAEEPPGGVRLPLRATYGRAPPPPPLPSFSPSFPPSFPPYPANSIKPTHTNPKKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Z8</accession>
    <name>F9W5Z8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000805">
        <property type="protein sequence ID" value="CCD12601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34670"/>
    <dbReference type="OMA" id="AENWNEL"/>
    <dbReference type="OrthoDB" id="1618074at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="24493" checksum="17652AB1B1D4270F" modified="2011-10-19" version="1">MPTPSQSEREALRRRFSEAAKSLSELYRDATHSYDAGYRDALHLLQRYILIASSGNTSTPNFFSTVSGASCSTDRRRNANGSTTALSSQLQQKEGTSVAEVPQVLDVTQLLGFIRNALKRHDVLSAASRGLARRRKRSPHPAVQRTDSAAGEGGFDTTDSNGNGYNCLRGYATRAGRRIPMRRLHSPLRRDAEGNELLLLGEVDAARSALVDLSSSDDDVVEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6A0</accession>
    <name>F9W6A0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000841">
        <property type="protein sequence ID" value="CCD12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35620"/>
    <dbReference type="OrthoDB" id="1739582at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17575" checksum="ABEC0AA41FCA0A67" modified="2011-10-19" version="1">MTTRHRGHMATLVFCGKMSTLRHWTHVTLNCRMGVTAAQSGQRTDGAPIGYASVTWQPWQAICPVQYRSGGMNQLVLPCYATCNVYICIYMCVCVSCVTCACSLFALLQIPLKLLSQDPFYSFLLSKFLLFFYFSRYCVGFSQFEGFFAACGVCSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D7</accession>
    <name>F9W6D7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000852">
        <property type="protein sequence ID" value="CCD12742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35960"/>
    <dbReference type="OrthoDB" id="1323965at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="16194" checksum="3F23EAB48619620E" modified="2011-10-19" version="1">MFFTVDGLLVERCDGGASGDILGVSDGRQLIVLHRLLHRLHSSKGDLQEDGRKPFVGGGALLDPPCGSVGVTAIGENTNLVANDGVVGLARWDDGSDMSGGVALVLSTSERTLSCAQRKVPDTGDTLFWCTATAKDGCGMRDFSVGAGNADTVGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6F9</accession>
    <name>F9W6F9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000862">
        <property type="protein sequence ID" value="CCD12764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36170"/>
    <dbReference type="OMA" id="HEMTNTH"/>
    <dbReference type="OrthoDB" id="1671522at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="508" mass="55823" checksum="9A207AD40D7608A2" modified="2011-10-19" version="1">MTTVECSCSSCMCCESCSCSCTVSCCCDCAADAGGDVKPSVSTRWEAPSRPLQLSHDRRKSASTSSGGSCSCSCSTSAASISTRSYSCSCSSYSTSCRCSSAEERNKAPRSVHCPSPAHDSYWGLGAVPPLLRLGRASRPPVQPGPRMVLFSTASGLLPPPDPLSTTTTVTSPHASSAGHSGSSDTTVPVASFDATPRPREEALSVVVIPQKCSIEVQVEERFSRGTSPTRPQCRDVGTATELSLDILEQQERLLEMQTTTLRGHAERHSVLELERASIEGELSVFREKAEQHRILQTDIFMNQFLEAVLWCRGTVEAQQEEQRDAISSLRFSSEGLIASRHEMTNTHKQFLLELTSYQLTMHEKNIHDLLLSEMWHRGVISDMEAQSRLNTAVFRSVISEAERSNAQVALAQAEAERERQRATTLQQRMEEAEKRERELRLMYMRVLTLPTTTIVTRSPESHSGNNHMSGGDDDAIPVHVRFARAHRAAAETVMAQRRCSLALRCGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J7</accession>
    <name>F9W6J7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000887">
        <property type="protein sequence ID" value="CCD12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11128" checksum="C1D6729BA394815C" modified="2011-10-19" version="1">MGKRRGPCIGRAQICSFPGELCVSIRSGRTDPCLPLIPKHYTAPCLFISSLFIIIIIIIIIIIIIIIIYSLYIHFKCYPESSLYPLSALLPCPPAPVSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6L7</accession>
    <name>F9W6L7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000894">
        <property type="protein sequence ID" value="CCD12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03670"/>
    <dbReference type="OrthoDB" id="1714257at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17824" checksum="D2EB20C3CA6B336B" modified="2011-10-19" version="1">MMQPLGEFLDNFLPLRILFDVVGWVFQENSEGHIGVAGSVGCPLFLSYKVNEASVFQEFACLPEDLFQLIVPSPSWLTPCVWSAGCLMCELVTFLVSPLHGYASACYGRPRLLADFSDGFIQYKSWSPGQQCTRCTKSPIAESYDAIAHKVPDVFDRIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6L9</accession>
    <name>F9W6L9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000895">
        <property type="protein sequence ID" value="CCD12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36700"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17056" checksum="3CAF405309453882" modified="2011-10-19" version="1">MAPLTCGMSGVMAGVSHLVACPQAVASFSGGSRALCEGTESERHGHTSGIMKALMGLRCLLEAYSLLSLRAAADVTTSLLDLKALFPHVELPCEALRLFCCRATNSDEWRELSPVLVSGVSRVSSHLSVRCVARAARALFGLTNKVLQQQWQDSHGTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N1</accession>
    <name>F9W6N1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_36790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36790"/>
    <dbReference type="OrthoDB" id="1665173at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394584" evidence="5">
        <location>
            <begin position="19"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="75"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43865" checksum="D1EF7E19A0A4C7DE" modified="2011-10-19" version="1">MMKHLIVCLVFMGGWVREGRVMANADVSVNENENREYFSLLCRIYNVAKNPPMKPVDTKEYQKIVEDINALSAAANGKERVNTQSEETRADQTQLIGITREAHKLLDGIKKVNPEGEVEKVKNTFNQVIFGKNGKEDLSQRGLEVVDSRMTACGGKDKGSSAGKNLVVDFFCVCAQHTEDSDGVDKVCGVSVGNGRDSRWEGGKLDSPDTMWKEVKDGCEKFATQGVTSTQDGYSVYHDFLDKVMAGGKVKAKNSETVQTRGMLGTAVSITVGSKFNCNGQRTVPPRYSSSSGRCVFYGEQHLEENIAWLKKFKEGLNIIDKLNTETASWQHQLTTLLNRARELYEKVKADSLVEEVDMDESPLAQHPNPDENENADSTTQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R6</accession>
    <name>F9W6R6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1511</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000920">
        <property type="protein sequence ID" value="CCD12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37120"/>
    <dbReference type="OMA" id="DHFWITF"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="146"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37269" checksum="A41E6952F2302A13" modified="2011-10-19" version="1">MQHHRHSGVNEVGRILPCTCGRATLDAQRILLLVSGDVERNPGPMIRGAQWNAGGLSQVKRIALERKLHEDMVLFCLLQETHLASAECAALKIGGYQHVGQARTPHGGGVSILVRDGVGVEVGILEKEVPERATVTLRFSADVSLTIISAYFPRKADVSSEALDTLLGANGAMVIGADVNSHHVLWDPLRPSDDKGESIVDWRVQNNMRIANTGLATRRQPVTVVLSLPDITLCRDCEISNWKSPLSPDSDHFWITFDAFVGTSMDVMAPSKPVRALYSWNKARWKEFRKMSDNFIIQRIKRSAKGVGAYNVAITRGIRIAAKRTIPKGKGVAPPFWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y7</accession>
    <name>F9W6Y7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1536</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000948">
        <property type="protein sequence ID" value="CCD12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37650"/>
    <dbReference type="OrthoDB" id="1720374at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20958" checksum="37E00548ACBA0BB3" modified="2011-10-19" version="1" fragment="single">MDAKDPNDVAFEKKESLLEVTQIAIDAGHVDVVQRQFNKLLYQVVDLSSKIIDLTSSALNETGTEPEHHVDTLVGLQKVEKQRSTSSRRNSASSVASSARKASMWRVSTRQGTPVSTTSRSQREKSQPMINNGTSPDADNDSRRPVLRRASYGVARGSFSRGEQQNILGDGCKRRSVPQQILRRYPCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z2</accession>
    <name>F9W6Z2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_37710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000952">
        <property type="protein sequence ID" value="CCD12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37710"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388743" evidence="5">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="80"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="401" mass="44874" checksum="D9B4E2D9A98A514C" modified="2011-10-19" version="1">MMKLFMVMVIMVVMGSWVREWRVNANTEDYVKENDNRGPFELLCKIYNVANHPPIKPVDTKEYQKIVDDIDALRAAANGKERVNTQSEETKSAQTQLIRITHEARKLLEEIKRVNPEGEAESARHAFNQVIFGKNGKEDLSQRGLEVVKSRPVACGRKPLDKKGESAGKNLIVDFFCLCAKHDHAEGVDKVCGVSVGSGDGAGWRGEKLDSIATMWDEVKDGCEKFSKRGVTSTQDGYSLYHDFLAKVKAGGNIKVKKTETIPKHGMLGTAVSETGKNDLNCNGKKEVSTSRTSSSGSGVCIFYGNHHQEQNIEWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKAESQLEEVDMEEPIAAQHPNPDENENADSSTRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W768</accession>
    <name>F9W768_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38490"/>
    <dbReference type="OMA" id="EGCPRNS"/>
    <dbReference type="OrthoDB" id="1268130at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="468" mass="51124" checksum="6DEC7717210A638C" modified="2011-10-19" version="1">MHFHVGKVVMHPLASQLVSHFPLLIPLLSLNLPTKKAKGVLNKAAASHAALSLTAEVRHTQWRVMQSTKAKVTKQEQHNVPVTLSTSSSASVYLTTITNRIAARHGVSFLILKPVEYTGQTKEPQESIKNSMKGAIAKGSTNNPQAMEKFKQSAEMWSAMWAQPSGSVGSQVQTQHRVRPILPASLLLLFSDMGMSKPYEPLGLLGLLKPEDEVVSRCFRGAEARQSPLQPVICIYLNALESIIEVTDRLSAQAKAMYCQIYRENALKRGTDVANHGGNSTKSADNSPEKCRSRFFLLTPSAPYAALRETANRIVNDEDTGLTGTGTSLGLGEACEILLVYDLNHSSHSFARDHSPECNPEVWGHVNYQQKRSGNSSGDAHERDELFFIAQTLEDYFRLGSTFSWVYGWQLCYASQGPPARSLSWLKLFSPNALAAVVTLNALGSGSKSTAADKTSAITPDPDTRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W795</accession>
    <name>F9W795_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001002">
        <property type="protein sequence ID" value="CCD13060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HEHKTRG"/>
    <dbReference type="OrthoDB" id="1474448at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="894"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1499" mass="174601" checksum="B4E97557354B3C2F" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B4</accession>
    <name>F9W7B4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04060"/>
    <dbReference type="OrthoDB" id="1706677at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="21154" checksum="6B6DB65D322FECAE" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVDVLLDGVTSADSINLYWFLRPVLDCLPVDLVCFTLRDFVRNPRHCIPEANVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYFDMDDMPLEAIDEEIWRRCRRPPPPYQPCQGVVWVEAAPAFIQVPYSTVGYLVQIPITPQPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7D8</accession>
    <name>F9W7D8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein TCIL3000_11_16270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_38890</name>
        <name evidence="7" type="ORF">TCIL3000_11_16270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC96117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001011">
        <property type="protein sequence ID" value="CCD13104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.16270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38890"/>
    <dbReference type="OMA" id="FHFISGW"/>
    <dbReference type="OrthoDB" id="1375317at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC96117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="21087" checksum="712DFA52C1DF032D" modified="2011-10-19" version="1">MRILQQQAEVWHAVLHPSKHSWGERKRAYLFLFAYCLAIATLIASLMHFIGAWVACGLLQLVMLIFSMTFALNIADCRDKCLNVLECERAINPILEVYIALRVAQLLHTAFILCDIPMSIGIVLALLYSLWRLWYGSYFVDATSLWREVGRLEKESYIYIAVDTLLFAAYLVILVFVMVNRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7H3</accession>
    <name>F9W7H3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1611</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001032">
        <property type="protein sequence ID" value="CCD13139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39190"/>
    <dbReference type="OrthoDB" id="1718111at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17544" checksum="C761788B30BA8FC1" modified="2011-10-19" version="1">MIIHSPCTQHIAGIGNSNAVTLPSALVCCLHSILRSTVHTATPHLSQPPFNHIVRSSSHTATEAALTAYFHVTENYPTEFHFILKLTHTQVSPNDTHSKHHPLIPNEATGLTKLQGLYATRGLEFGFPARLGRLLAREGYFPVCPYLSHRLFVLYRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7L6</accession>
    <name>F9W7L6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein TCIL3000_8_1120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39580</name>
        <name evidence="5" type="ORF">TCIL3000_8_1120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC91902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001050">
        <property type="protein sequence ID" value="CCD13184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_1120"/>
    <dbReference type="OMA" id="KSQIYPR"/>
    <dbReference type="OrthoDB" id="1236176at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC91902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="239" mass="26980" checksum="76FAF528E4D26576" modified="2011-10-19" version="1">MTSKVEELAAEVKDALEKVETAAQTVFDASTLLEKKQAEIQVKPVMRETRSKIAALRDELRQVDDASVRTHYDKFCRTSEENIRQLDARIKQHIFGHKGDMAKAPSHAEKREGELLGEGGADGSGFQDAEQVLQSAVNVQKDMLVSLQRTEQVMVMTEELGQETLKTLQRQTELMYQVDEGLEDLQGQLDRASRDVRWFYRQLAADKCFLSLFGILVVCMAVLMGIMIYKKRHAKATGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N0</accession>
    <name>F9W7N0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1633</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_39710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001057">
        <property type="protein sequence ID" value="CCD13201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39710"/>
    <dbReference type="OMA" id="RCYITCA"/>
    <dbReference type="OrthoDB" id="1492at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHC_N2" evidence="1">
        <location>
            <begin position="208"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_6" evidence="2">
        <location>
            <begin position="761"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="859" mass="99166" checksum="00FEC4A7780250FB" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P0</accession>
    <name>F9W7P0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001059">
        <property type="protein sequence ID" value="CCD13212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12237" checksum="AF451534ED8BDF71" modified="2011-10-19" version="1">MLSKHVGELVVCSVIVCSVAFCSALFSLTPRTPRQAWIWFSMLSILVLILSWTALKALKASEAFLRCTICLAGPAFLVALLTVTSAISPAIKLPLLVRSPANFLSIVKMQPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y7</accession>
    <name>F9W7Y7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1676</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001104">
        <property type="protein sequence ID" value="CCD13309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40760"/>
    <dbReference type="OrthoDB" id="832727at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19593" checksum="F0C0FDC3E949F2FE" modified="2011-10-19" version="1">MLNVMSVVNERQCILPLLRHLYLNNMNLDYRSLHGIVCYLFPVRRFRRARDGSQPRPDRTIAGEEFGIPPEVYFPFRGTPRRALFPSLSVLSLCDNPGIGNGGLVELLRCLIAPHFEERVLPVLDLSRCGIDEVGARYIREYIEKLPAVLNDDNTGIAVQRIVLYGNRHSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W864</accession>
    <name>F9W864_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1709</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001140">
        <property type="protein sequence ID" value="CCD13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41480"/>
    <dbReference type="OMA" id="DHRDWHE"/>
    <dbReference type="OrthoDB" id="1492at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHC_N1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1273" mass="146061" checksum="779EFAC496A1F50C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W890</accession>
    <name>F9W890_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41710"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20126" checksum="BDDECD25995AD16E" modified="2011-10-19" version="1">MSKSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPFIHSYISRFSITDFARNPWRCVGEADGREQVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Y0</accession>
    <name>F9W8Y0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1797</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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            <end position="242"/>
        </location>
    </feature>
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        <location>
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            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="976" mass="105592" checksum="6667109915F512D0" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
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    </gene>
    <organism evidence="1 2">
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
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        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="16357" checksum="3874DFE6901F28CB" modified="2011-10-19" version="1">MFAHKFLCLFDVVKIERWKGWCDTVLLPRHDGVGALWRVGGNEWNFVQGESGGETQRNSLRVLQQQQEEEGERMVYSLLRITCASYLHHMLAITFARSLLCFIRLTGASANLFRVLWSRCMHLFPKEVERKGEKGITSRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W934</accession>
    <name>F9W934_TRYCI</name>
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 18</fullName>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001255">
        <property type="protein sequence ID" value="CCD13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00430"/>
    <dbReference type="OMA" id="VESIHCE"/>
    <dbReference type="OrthoDB" id="1651489at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="338"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="552"/>
        </location>
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            <end position="24"/>
        </location>
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            <begin position="31"/>
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            <end position="122"/>
        </location>
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        <location>
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        </location>
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            <begin position="599"/>
            <end position="613"/>
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        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="865" mass="92343" checksum="56F34873732EA53F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9E9</accession>
    <name>F9W9E9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1854</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TCIL3000_0_45400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001302">
        <property type="protein sequence ID" value="CCD13849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45400"/>
    <dbReference type="OMA" id="KREELMC"/>
    <dbReference type="OrthoDB" id="1626459at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="27022" checksum="A11C2ECDE7DD1330" modified="2011-10-19" version="1">MQQRADNFVGGNVQEIAHHGNFVSTDYRYDEDTPDGVMVLRSPKANEPPLHLTEIPQHFLLNPKPPVQLKDRPDICDGSSWPRFHVPVHRPLPRRTWSPRDDRRRDTHLKSFLAPLFTDRDAEERVTLSFLQPPENNPRQEVEERKKREELMCKFYKSTNVQEEVAVRMPNLQRKVSNAFVPQCAASYTQSRIAQVEESRKRQVEIAEAMSKRASKQMWGRPSVERRETAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9F0</accession>
    <name>F9W9F0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001302">
        <property type="protein sequence ID" value="CCD13850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14442" checksum="690E98B772347909" modified="2011-10-19" version="1">MTNLHIAHVCPTSAYCFLGVLAPSSSHCCHVLFITFGQANLVPFTEVAQVMVIAFRNPLIFHAAAKSLMPMSGTTIYEYVVVRTPWSSSHFATRTSSRHTRVNGCSSQQCNIARKIPVHLCTSNKANAPTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9G3</accession>
    <name>F9W9G3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001305">
        <property type="protein sequence ID" value="CCD13863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45540"/>
    <dbReference type="OMA" id="TSCCGAV"/>
    <dbReference type="OrthoDB" id="869918at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38472" checksum="A56D83EF7DE56779" modified="2011-10-19" version="1">MRFLVIDGDGSTSAHELPQSQLMLHSFQGTDEDSDTVRAMVHSSTLVGLCQHLLETSILPARVAPDLSVMALALLHENFAVSRNSIRLVTPKRTAMQLFSVDDLLEPGKLVIFVSRWESLASAAVIVPKLGQRPQRDLSNSGRARLEDHNKNSRGNREPPLSRLAAFPGRGLETATKIAYAETHFHSVHPATLHDLDLLNRLLLAGTIRLDPKVETYLCSVCGCLPRQTLTTSCCGAVMCAMCIPLISTTTSGMSTVREKYMCAVCHEFPFTSHVTHPNRDAEIMRLVRELRVLHHPQFVAASATTVHCGPNEPRHQPIPIMMRNMGMAPTKHDVANATAPVLGSIFQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M7</accession>
    <name>F9W9M7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001331">
        <property type="protein sequence ID" value="CCD13931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46170"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="26129" checksum="FD550649F59B14C3" modified="2011-10-19" version="1">MDIDALTRIMTRRVRRRFRYLLSLFVSHSADMSYRAKFTLSHDDAEKLRINNIIAPIHHSQIQGFAWPFCVAELKKAGWRRRMTLWSQEGNLVVRDIHGYTPPLNLYNRIKYLSSVWIGGPALRIDLKASFYQIPISKDASNKLTFWAGSRENGSWYAFKRLPMGHILSPEIMQIAMSTLMGDERFTKHTVTKGDVVIDTWLDDARILSSSARTITRLEQDITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9R1</accession>
    <name>F9W9R1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1888</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001339">
        <property type="protein sequence ID" value="CCD13966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46500"/>
    <dbReference type="OMA" id="TIACEQS"/>
    <dbReference type="OrthoDB" id="1326119at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="325" mass="35590" checksum="8AC89460245225EB" modified="2011-10-19" version="1">MALSSGSFPNFFPSLNGSNMHCFPDDTLTPLLSMRYEDGFMDPEPNNGSPSSMCNTPSFRFHNGLAWVENWQLSSSNLLPPTDYSAATGLSRTPSSFSTLRYSHDPYGVQGSSTQLPLPPVSGMIGRAPSPTGCASPFTHGGYGGEAALAFPPGAPPMALITGPPVAEHLQMGPGPRGATEVRGRRRGRMRDRDRGRAVRCLADAPPPTSMRYFPPPPPQCPDSTSPLRISQEALVRIATRWYQRTIACEQSYAGRLQPNCGAPTSMMVMRPQHMTGSLPVTLCPRMEFTPQFTFDHWLRAAGQWWDTVIRPLTAEYRLPPPYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA21</accession>
    <name>F9WA21_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1921</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001376">
        <property type="protein sequence ID" value="CCD14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47450"/>
    <dbReference type="OMA" id="FWEDLDF"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="492" mass="60547" checksum="DA3BBBB49EFDE3C0" modified="2011-10-19" version="1">MVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEIVQYCEMVQYCEIVQYCEIVQYCQILQYCEILQYCEIVQYCELLQYCEIVQYCQILQYCEILQYCEIVQYCELLQYCEIVQYCEILQYCEIVQYCEIVQYCEMVQYCEIVQYCELLQYCEIVQYCEIVQYCEIVQYCELLQYCEIVQYCEIVQYCELLQYCXILQYCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD4</accession>
    <name>F9WAD4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_48430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001415">
        <property type="protein sequence ID" value="CCD14195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48430"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="5">
        <location>
            <begin position="65"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="469" mass="49688" checksum="0F417823DEFD0892" modified="2011-10-19" version="1">MSEALGPSNMNSTAPQSIDDSVMAITRGTRHELDKAPPEDSKENVGCFAKAGAFMAIIMPPGGIAASAFNIGSTTVGAGIFGLPAASQGSGLVMAMFYLLVITAMAVFSTYALGVAADRSKVNTYEGVARVLLGKWGAYSLAGVRAFHGFSGCVAYVISTGDILHATLKNSSASDFLKTTAGNRLLTFIMWLCCMLPLVIPRHIDSLRHASTVAFVLMIYMVAVVVVHSCMNGLPENIKSVSVGRNESAEVVLFNSGNTAIEGLGVFIFAYVCQTSVYEVYMDMKDRSVRKLVIATIIAMAMCLPMYALTALFGYLDFGSKATSSILLMYDPLNEPEVLIGYVGVLVMLFVSYALLGMACRNGIYSLIGWDANTVAFWKHCIAVVSLSVVMLLCGLFIPKINTVLGFAGSISGAFLAFIFPALFLMYSGGFTLQKVGPLCYIATYVLLLSGVIAAVFGTGATIYGVVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAE5</accession>
    <name>F9WAE5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001423">
        <property type="protein sequence ID" value="CCD14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15395" checksum="341C398FC3BE3FAD" modified="2011-10-19" version="1">MWDDSLASMDTEEKEKAKRMSRAKLIVRCRHFNFQPVRDKRPAPPFTDGPFEVKVGWNWLRLAKRAIKRPPQQPPNAWDPSATHLNKALAREGKESNESAEGRDAYSNEVIAPTALPQYSCFDTLSHSKYQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG6</accession>
    <name>F9WAG6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_48730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001433">
        <property type="protein sequence ID" value="CCD14228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394809" evidence="10">
        <location>
            <begin position="23"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="492"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD14228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="846" mass="94685" checksum="DD740FB114147E5D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW7</accession>
    <name>F9WAW7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2024</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001491">
        <property type="protein sequence ID" value="CCD14390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50080"/>
    <dbReference type="OrthoDB" id="1685676at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="30039" checksum="299483A3954937A1" modified="2011-10-19" version="1">MSKVFETSKYRLGGEGRPVKKRDLLECFQTGKRSEVGKANLAKIPESVKEKSGPDVYASIKTINHSAMDVHLKKGGVDDSHAGYNLIKKTSGILSSSLQDKLWWCGGILTIRKGFREDVNTESFAAGDISDNTTAGINSNNIKAAWTNSPATKIVHLANTLDEIKNLTEKKRQIDGIFKGVRAKIEKCFAFQGKSDKKSGSVGQTCLDNAAQLATELQAVNALLAIYRKQQDEFKSRPTESVTITVNETINTTNLAAAGKNYPSKGEYFFLASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBR1</accession>
    <name>F9WBR1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_52890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001616">
        <property type="protein sequence ID" value="CCD14695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52890"/>
    <dbReference type="OMA" id="QEMYNLK"/>
    <dbReference type="OrthoDB" id="994469at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="LRRcap" evidence="3">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="LRRcap" evidence="3">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="domain" description="LRRcap" evidence="3">
        <location>
            <begin position="1383"/>
            <end position="1401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1497" mass="168784" checksum="F111E6CCDDF3396F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBR8</accession>
    <name>F9WBR8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001619">
        <property type="protein sequence ID" value="CCD14702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52960"/>
    <dbReference type="OMA" id="HRINVEY"/>
    <dbReference type="OrthoDB" id="811536at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Afi1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="723" mass="80288" checksum="CFFFBB0031BB0EF5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT3</accession>
    <name>F9WBT3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53120"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388949" evidence="5">
        <location>
            <begin position="21"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="33"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="358" mass="39437" checksum="A21F8281F357A5DD" modified="2011-10-19" version="1">MREYVMLFSFIPLMVEFSLCHDNAEYRLLCNVFKSAEWALNNSIRNGQLKEAIHGESSKAQFDKQGTIKSLGIRCGGQLSGRAVVCTSRSGGHGGDGCFSRSLVGTILCVCTPGKTGINQNCGAIEFRDKMWHGGFGSAGQRLDEKKDLFRKVWQAFIKNCRNGVQYNRGTVGQLENLKKSIKSITESFKNSDSHFYLGGGNEKNVCGAETVEDTCAKYERRGGRAEIPWVEKIENALGELEILRKTTVVSVQEPGNAHSTCGDVSPAKPARVNEGISEKQVQNEHTLEETDLQTSDKESESVTTGGTISVTEQHRRRKRSTSNSLSTSEIPHLASNPNEDGIFLTCPRWLLLAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBV0</accession>
    <name>F9WBV0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001626">
        <property type="protein sequence ID" value="CCD14736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53290"/>
    <dbReference type="OrthoDB" id="984036at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="21099" checksum="5DBFABC62B6C6F22" modified="2011-10-19" version="1">MMRFYSLNRTTTNAKWDVLLFNAKHGLVECMFYRTPAGCLSSECTFEHSTIPAVTITPPLQNMTTNNALLTPLLGFGVTATSATPCTTTSASNISSNALTAATPAGGLAPKPFIGGNSLRIPVDTTRHLAAAPVVDKPDDVMMFRDPVWGSCGTQEKRTTQQSQQQQQQQAQQQQNGVTIFWGPGERNLSETFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC26</accession>
    <name>F9WC26_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 2176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_53950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001659">
        <property type="protein sequence ID" value="CCD14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53950"/>
    <dbReference type="OrthoDB" id="1676846at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394855" evidence="9">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="38"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD14814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="322" mass="34566" checksum="834B272896F751D0" modified="2011-10-19" version="1">MLMEPRSTWWLFLSVVILLSPDNAFCDGPKAIPTKAGAAICTLSKTLKDVTPWATQQVENAAAKITHLEMKLLEWQTKFIQSKSKGIGAEACKITGLLFRQVGKEIERARKEVEKLEKEASKAAAFAANSAGRLDEFITVFANAKGESSNYCMGDNSAAKPEDLRDCFSRPDFGEESLVDIGENAGGKEPNLGTAIEGIKHTSLKDNFGGGSSAGCNLIKGNTGGILGKTYLEKSLWWGGGVLTIGKKFEGVLSTSSLIAGEIVNATDDKATWTADPAQHIVHLKNSSDAFKAFKAVQEKIKEKVESIEDKNSSCMGRTGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC43</accession>
    <name>F9WC43_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="7">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_54130</name>
        <name evidence="9" type="ORF">TCIL3000_11_2430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="7"/>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC94851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001664">
        <property type="protein sequence ID" value="CCD14835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.2430"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54130"/>
    <dbReference type="OMA" id="ANNFNGA"/>
    <dbReference type="OrthoDB" id="460209at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:3-oxoacid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="8">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC94851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="492" mass="52891" checksum="7A020600366B5201" modified="2011-10-19" version="1">MLRRTIFFRAGLDKVVPMAKAVKDIGNGASLAVGGFGTAGMPHAVMQEIKKLGVRDLSIYSDAAGVDGYGIGVLFENKQIRKMIVSYVGNNKIFAKQYLEGDIELEFCPQGSLAERMRAGGAGIPAFYSPAGVGTILQTGGQITKYDKKGAVVMESVPRETRFFNGRLYCMETAIKTDFSVVKAWKADRSGNLVFRGTARNFSVPCGQCGNVVIAEVENLVENGALDPDEIHLPGVYIDRIVVPERYETLIERRTVTKRGDAQKVSKAATPADEVRQRIARRAALEFADGMYVNLGIGIPTESSNYIPAGVNVVLQSENGLIGMGPFPTEDKVDADWINAGKQTISYLPGAAVFDSATSFAMIRGGHMNLTMLGALEVAANGDLANFMIPGKLVKGPGGAMDLVSCGTRVVVTTTHCNKSGESKIVERCRLPVTGKHCVCRIITEFAVFDVVSGQLVLKELAEGTTVDQVKKMTAAHFEVDRVVTMPLAPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCC6</accession>
    <name>F9WCC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_54880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54880"/>
    <dbReference type="OMA" id="CEPSIVP"/>
    <dbReference type="OrthoDB" id="1019206at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43696" checksum="68D3F316EB24B64B" modified="2011-10-19" version="1">MSELEIRGDKKFWRLKRQRILGKGSFGCATLYEEVGDGVSEGSEPSYVVVKDVNMQTMKKEEELKALEMEVSILRRSIGHPNIVQFLDYHHDGEFMAYIVMEFCTGGDLGQRIEQLRYRREKEDERFVASLMIQMLVGLNFLHVDQRTLHRDIKPQNIFIFSDGTVRIGDFGVSVVLDQLGGVAKMACGSPFYMAPELCEERAYDGKADVWSLGVTLYELMTLKRPFNSTSAPALVRLISSGEFDRITPDDGFSAPLIDLVHSFLQKSAVTRPTLRRALRSSYVQNNLYTVPLACLQSKYYKEIFGEELVQKAITTQTKAVGVGSGGNLGGKSNVASVGGDGVISRDAPSSSTAPGKASFSAAEIDLWLQQGTDAAEELIQQSLAPRRPRSAAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE4</accession>
    <name>F9WCE4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_55050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001707">
        <property type="protein sequence ID" value="CCD14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C26.A21"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55050"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="392369at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="10">
        <location>
            <begin position="201"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="229"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="657" mass="72068" checksum="5CABDD9043A18E76" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCK3</accession>
    <name>F9WCK3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001734">
        <property type="protein sequence ID" value="CCD14997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55630"/>
    <dbReference type="OrthoDB" id="1202220at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="4"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="95"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="40497" checksum="E7D650CBEB535133" modified="2011-10-19" version="1">MSLSNLFVTKLPRSINDSGLLSIFTGFKAISAKVMLDPCSGSSKGFGFVLFDTEEDGLAAYQSLNNSSARVGRHVFTLVIYPSQHNGKAAASPSRAVYIRNIPRSIEEHEVEKFLSQYGRLEYWAMRGDHHGSPVWVVYAEYDSLESSRRVLERLHGNSDYFHGPPIMVKYADSEEAKRERRRRWGEGRSSQPLNRICSFLPHGRKYSSMNYQQNELTETSQSLTQKNSESSNSSIVYQCLESSNSACTVECQPQLPSELYSQPELPLPRPALPRSSEVAVDLPYVGIDALTHFPVSDTADNEKGVFLNGQRVVLSSNAVNFPLGDSSTSTIAAVKPTVQVPVTCTAVPHCITSQQQQQHRQVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCR1</accession>
    <name>F9WCR1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56230"/>
    <dbReference type="OrthoDB" id="1736409at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="20651" checksum="37D918025382119F" modified="2011-10-19" version="1">MQSKTREMLLKGMKHLLNLNISDFLRLYYMDVKKRVARFTVEDLRRHPERRIKDKDRRKDIGMSMSRMRSRLRDRLLRTSWDLFSYHIKTLEDWTRKGSPKPLDSIARGLLNQALRNIQELVHIKHQAIVPSSSSSPSKHEGSPTNVGFLGVILLRRRKSVPPPQGEKPQQEMIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD36</accession>
    <name>F9WD36_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 2317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_57340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001816">
        <property type="protein sequence ID" value="CCD15185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57340"/>
    <dbReference type="OrthoDB" id="1680832at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD15185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36299" checksum="DA18B4F806BEE326" modified="2011-10-19" version="1">MKLLEWQSKFLQSKSKGSGSEECKITSLLFRQVRKEIDKARTGMERLEKEASKAAAFAANSAGRLEEFITVFANAKNSSNGFCLGNGKAATPKELKDCFSGTDFREKSLVDISERVSEQEPNLDSKIEGIKHQSLRDSLGGGNNVGFNLTKGTKGGILKRTKLENSLWWGGGILSIGKGFDGNLGSSQNFGAGEIANNTKEGKHALWTENPATHIVHLKNASDAFKTFKAVQEKIKEKVESIEQQIQACMRDQESGENNTEQNATKHTTTTEQTPTSLTCFDNVVKIAAYLKEKRALLARYQRVKGWIPPSSTFNAKIAVTLFVILLAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD79</accession>
    <name>F9WD79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001835">
        <property type="protein sequence ID" value="CCD15230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57720"/>
    <dbReference type="OrthoDB" id="129942at199999999"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21273" checksum="CF9F3A824254CCCC" modified="2011-10-19" version="1">MSWYTITSTRTIPWSMEKDVVDVLLDGVTSADHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEANVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDNDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVWVGGTPSSIQVPYSTMGYLVPIPVTPRDWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA6</accession>
    <name>F9WDA6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2342</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001845">
        <property type="protein sequence ID" value="CCD15259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57940"/>
    <dbReference type="OrthoDB" id="1728713at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="16906" checksum="FE103BB06C904B40" modified="2011-10-19" version="1" fragment="single">MVAIRTRRQPPRNPSWTMRSTIREVLVEGMKDPHNLNLFDFLHPYYRDVPENVARFTVGDFLRDPERCIEGKVRRRGIGMSLSQIRARLRERLLHTSYGLFLYRIRRGTQPKTPHPTRGFSLDEAVKQVQEAHTQVEEPVRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDE3</accession>
    <name>F9WDE3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58270"/>
    <dbReference type="OrthoDB" id="1712519at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21323" checksum="32F16E63814BBA1B" modified="2011-10-19" version="1">MSFYTITSPRTRPWSMEKDVVEVLLDGVASPDHVNLYWFLRPVLAGLTVDLVCFTLGDFIRNPRHCIPEVNVCDALWQYLPYLLWKFRLSATPLVKHFGPTETWKKWHWDSWKIYYDMDDMPLEAIDEEVWRRCRRPPPVPQYQPCQGVVVVEAAPAFIQVPYSTMGYLVQIPISPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDK5</accession>
    <name>F9WDK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2374</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001880">
        <property type="protein sequence ID" value="CCD15359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58860"/>
    <dbReference type="OMA" id="DARAYMP"/>
    <dbReference type="OrthoDB" id="212058at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1890" mass="202622" checksum="613E8DBF8A3DA394" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDK9</accession>
    <name>F9WDK9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Squalene monooxygenase</fullName>
            <ecNumber evidence="3 8">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_58900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="3 8"/>
    <dbReference type="EMBL" id="CAEQ01001883">
        <property type="protein sequence ID" value="CCD15363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58900"/>
    <dbReference type="OMA" id="PSHIYEV"/>
    <dbReference type="OrthoDB" id="583514at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="PTHR10835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SE" evidence="9">
        <location>
            <begin position="122"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD15363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="481" mass="52745" checksum="4C7D2CF0326E04AE" modified="2011-10-19" version="1">MDECVTSIGMPCDGYVVVDEGGRQIELPYAEGEAGYSFHFGDLVYNLRRHVWNECRTAVTMLEATVTEVLVERVAPCVDRAYGVAYVMRNGANVPELPFADVSTARTESVDAGADVYCVATAPLIVMCDGGSSKFKALHQHYTPAANYHSHFVGLIVRNARLPLERHGTVFFGKNGPILSYRLDPNELRFLVDYNKAALPSLEEQSRWLTDEIAPCLPADMRPEFIKAAQTVLNIRSMPIACYPAAFPSIMGYVGIGDHANQRHPLTGGGMTCAFNDALLLAAKLSAIGDLRATNVATMSKIQGKLQEAIISYARARVAHSASINILSWALYDVFCAPLLRNACLDYFLRGGEAVSVPMALLSGLDSRPQQLLWHYALVMLRGAQSLVTRGGRYGNRDKADSFTSNRVNTAKFRVAPSHIYEVFQLLFSAVLVAVPVSYNEFVSLWRLVDPTGFLAFIFKTARVASYRLSARGVNGKPVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL6</accession>
    <name>F9WDL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001884">
        <property type="protein sequence ID" value="CCD15370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58970"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20111" checksum="D07D42327EBAF88A" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPFIHSYISRFSITDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ3</accession>
    <name>F9WDQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2389</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001896">
        <property type="protein sequence ID" value="CCD15407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59340"/>
    <dbReference type="OMA" id="CTANMSK"/>
    <dbReference type="OrthoDB" id="479815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30536" checksum="A19344BBB0156E11" modified="2011-10-19" version="1" fragment="single">MNPVCVLVELEGRRDFYHLRQRLGGDGYKTTAVDVQPWLDEEETRVYRHLARCFFYPAHQEPPSSELKEIADSFVRLLKETVVRPLRRLCSVVPDCLELRVCNEPWRKCAGHGNSLSLSPLAGVDAEMKRTSTDELSRCYRAMRWRWSDFFCGKDSYSGKAVLEGETVSPSFEQWDATTLSSMRRVGDAISEVQKDLMLMLNNMGEGNIGLALDSSTGGVRNSLWPELVRLIENAFNSVVSDIVELILWCIQQSLLGEGVFFGRPMFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDT2</accession>
    <name>F9WDT2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001911">
        <property type="protein sequence ID" value="CCD15436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15301" checksum="E268C524AC7A16F7" modified="2011-10-19" version="1">MFSPHLPYGYVLIVEVLLQALLVTFLLNGWCVYVATILFRIISLPLGIFAHKKCPSDFFPAAPVTVSLLSYRTSTVAGGPGIGYVQLCFGLLTRFLVPRLVEGFLLEFLPGSRLHWPGVCLPFTLIFPRSFFSPHSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE33</accession>
    <name>F9WE33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06360"/>
    <dbReference type="OMA" id="RIMPRDA"/>
    <dbReference type="OrthoDB" id="326501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="577" mass="63658" checksum="9890725118CAE90C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE43</accession>
    <name>F9WE43_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001949">
        <property type="protein sequence ID" value="CCD15549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17274" checksum="9CC5C11A675C4DB4" modified="2011-10-19" version="1">MLLYIISVRDNNNNNNNSNANNNNKYLFTSPVFFLFAAPSCALPSPFGNWLHHLAFYYYYLFKIFFLAIGPFLTSKVYRRDASIASCVAIVNTREHTCTVVLACIWRPSQSEDVKRVLGVTLTSFLFCFIFLSRRFFFFLLFFTWLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEH9</accession>
    <name>F9WEH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002015">
        <property type="protein sequence ID" value="CCD15689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07030"/>
    <dbReference type="OrthoDB" id="1733623at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17784" checksum="0AA06330FBD5A523" modified="2011-10-19" version="1">MCASRVRILFSSSPDSDVLKRHAIADFRLNQCRVKGSQHFSSRAHSEEAMAHGASATSYACRCLIAPPRWATPCVTELSVPGASQLLFPLAVCLSQPKLQRIRVPRSEERVLRLLSRRLHVKLIRSPPNAVQSFPRRLHDQLPVGISARSCKIVRKEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WES7</accession>
    <name>F9WES7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002058">
        <property type="protein sequence ID" value="CCD15793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08040"/>
    <dbReference type="OMA" id="HIHRWLH"/>
    <dbReference type="OrthoDB" id="462247at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="592" mass="66346" checksum="B0C313EFE8812450" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ0</accession>
    <name>F9WEZ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002080">
        <property type="protein sequence ID" value="CCD15856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08530"/>
    <dbReference type="OrthoDB" id="602576at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="278" mass="31072" checksum="A84B03898B94FC02" modified="2011-10-19" version="1">MLQKFYDGMRFVPPSLDAITGLILSSSILHKVSQRGSGGTAKRVTISGQQPPNRISRRSRSGLERSGMSPYFLEQVEKIPLVSLCNPESSFYVDCARCFRCITFRPGEHIVKRGTECNAVLFFCQGGAIVVDNESALRNSGGGGGVSTSGWLNLPRVPQGYIIGYTCVRRHLWERSIIAPDDGAEVWELSRWNFVEILRRYQIESQMHALVLQLMQPLCATAGRHAILDAQPLLTPSPASLWSEHKMPNFHPVSTSEVPRFPVWNESRLLCESSIQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ8</accession>
    <name>F9WEZ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002084">
        <property type="protein sequence ID" value="CCD15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00970"/>
    <dbReference type="OMA" id="CKDGRER"/>
    <dbReference type="OrthoDB" id="554921at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="625" mass="69634" checksum="59982B5F8A736D28" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF45</accession>
    <name>F9WF45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 350</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002104">
        <property type="protein sequence ID" value="CCD15913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09050"/>
    <dbReference type="OrthoDB" id="1718306at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20501" checksum="85C1BE52DD965892" modified="2011-10-19" version="1">MSGFEIWTQKRKAEDRIPITVALFVPSCCIITMLTLFLVLPKGVLPLPYSIAAVSNGFMAAAIALVARTMFAKDPAKHYNFCFLASILSIIFLNRLLYGEWYTRQAEKLGKSVCLDRVCVVMPLAFLLGLSFLAFITSTYVHFEYRALCNRALEERRRIKEDATRQREPAAEAADPQLANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF65</accession>
    <name>F9WF65_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 354</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09190"/>
    <dbReference type="OrthoDB" id="1675142at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="35821" checksum="4A74E3A5572C4D5F" modified="2011-10-19" version="1">MNMEGEREAVPNWTMESEVEQVLIQECKTRDKINLFYFFVEYYGWTEEKLLHLTLGEFLKQPERYLEDANRREEVQKTMQQMLKRLNDNTIKVVRCLVGNGIITLRDWALRGATTLLDHVPSGILDEAVREARKHPRSPITSRSTSVQRSNEASDKLTHQVTGTSSTQRQPGGTKDNELGEILQKACKSWEDVRLVDFLAQEYGKTYGACNPNVALAAFLENPSHYIEEDERRKEAVEKLPEKLHHLKGCILRDVTFLRTVGITTREQWAYRQLYYEMLTPITNCVLSRKYGSPYNERTNMEDALTVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF72</accession>
    <name>F9WF72_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="14781" checksum="5E0AD5E7D6A76055" modified="2011-10-19" version="1">MSVILLKTVLAPSPHITPYLAALCGSLLNIFGGVPSPPQSYLCHVGGVRNSRFVTVSSLPTCWLSPMPAVTPLDPVPVGTCHRRDGALNAAWSEPTLRDLRPPFRTVPLTTSVLVCAPQPISKAVSSCTSLHCSLQAANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFJ3</accession>
    <name>F9WFJ3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Thymidine kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_01250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8"/>
    <dbReference type="EMBL" id="CAEQ01002152">
        <property type="protein sequence ID" value="CCD16067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01250"/>
    <dbReference type="OMA" id="IGGANMY"/>
    <dbReference type="OrthoDB" id="1413914at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="27842" checksum="CD0A488D0951A97A" modified="2011-10-19" version="1">MFAGKTTELMSRVNRNFLARYSCYVIKYSKDKGYTKENISTYDRRTLPATVSVNKLSEVGNAWHDYDVIAVDGGQFFPDILEFCSMVANAGKKVIVAALDGDYRNEPFEHIAKLIPAAESVTKLSAVCMSCKSCDAYYTHRTVQSEQRELIGGAGMYIATCRACYNRLNNQGGSLVENPEGPQGGVAALHTVEDANELIPPGVDVASVDASCRDSGGSRTATPQSSPNSKLLGKRQRTPLESPSSPVDEKPVRKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFR0</accession>
    <name>F9WFR0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_10880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002179">
        <property type="protein sequence ID" value="CCD16137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10880"/>
    <dbReference type="OrthoDB" id="1668015at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395001" evidence="4">
        <location>
            <begin position="17"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="79"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40088" checksum="69F11FEC7CEC1504" modified="2011-10-19" version="1" fragment="single">MMKLFMVVMMVMGGWVREWRVMANGEDSVNEGDNRGPFELLCKIYNVAQHPPMKPVDTKEYQKMVDDINALSAAANGKESVNTQSEETKSAQTQLIGITREAQKLLGEIKKVNPEGEVERAKNTFNQVIFGEHGKEGDLYHGKVNGVQNRITACGSKEKEGTGAGKNLVVDFFCLCAEPSSGDEVVDKVCGVSVGSGRESGWGGGKLVSPDTMWNQVKSGCQKFATQSVTSTQTGYFLHREFVDTISAGGNVKVGSLETSRKPGMLGTAVSETRESNFNCNGKKEITVRDKVGSGSCVFYGNRKWAENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADTQLEEEDTDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX6</accession>
    <name>F9WFX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 434</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002197">
        <property type="protein sequence ID" value="CCD16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11540"/>
    <dbReference type="OrthoDB" id="532729at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18192" checksum="9A5E4530E68819BE" modified="2011-10-19" version="1">MITNNPELLDPALVRPGRFSTRLRMDYLRLPSFLDMLGLHFGTMAKGCEDQSGISNARESVRHQTDLGKICEVVSGVTEPVDIQGDIKTFPKLSSADVLRVREAISALCSNLNCQDDEGVAGIQISPAEVESICAVSSTLDEFLENFKKISVKEMVDLEDVGGTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE6</accession>
    <name>F9WGE6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_01560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01560"/>
    <dbReference type="OrthoDB" id="1674870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394756" evidence="10">
        <location>
            <begin position="25"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="29"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD16381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="42443" checksum="026A465633F6CB4B" modified="2011-10-19" version="1">MEPRSTWWLFPAAVIFLSPRAALCINPKAIPTKAGEAICTLSKTLKDITPWATQQVEEGSAKVTHLEMKLLEWQTKWVQSKAQGKGSETCKMTGFLFRQVRKEIDKVREEVEKLEKEASKAAAFAANSAGRLDEFITVFANARNDSGNGFCLGKEKAATPEDLRDCFSKTDFSEESLVDIGEKASVQEPNLYSTIEGIKHSKMISHFSGVSSSAGCNLIKGASGGILGKTNLEKSLWWGGGILTIGAGFGGELSSTNLIAGEIPNDTKEGKNALWTADPATQIVHLKNASDAFKAFKAVQEKIQEKVKSIEDKMEGCLTGQEPGENNTEPTTTTEQTPTSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPTTQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGG5</accession>
    <name>F9WGG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002269">
        <property type="protein sequence ID" value="CCD16401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17254" checksum="146D1FDE4438B38E" modified="2011-10-19" version="1">MMEPTQENNPITTPLTMESTVEAVLERARDDWGAMNAWNFFSIYYGNPYGMHRHTAVTMQQYLENPEKFVPDAAKREYIQLNLKLKRSLMQKNFQRDLAKLHEAKVVLLEDWSSYKEAVEIGPMTRMVLSGALIQALLQSPGSILYKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGJ2</accession>
    <name>F9WGJ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_13490</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002278">
        <property type="protein sequence ID" value="CCD16428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13490"/>
    <dbReference type="OrthoDB" id="1663142at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389116" evidence="4">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="96"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="46842" checksum="73150DB708A046B0" modified="2011-10-19" version="1">MACFVNVITVIIFMLLGGARGQLEVDKYDNIVPFSLLCRIYNVAKNPPISHVDLEEPFEIVEEINSLNASLVEPKLFNESEHMGNSVGAKLTSTVTKETALSQLSLNQITQKAHTILEEIKKMNVTETIGKAKADFNKVIFGENGNESDLCQATVKDVGDRATACGDTALSSKGSSAGNNLVVDFFCLCVQRQDGKGVNQVCGFYVGSGYENGQLGWNDTGLMGSSTMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLRTGGVHRWGTSKDKVEGSERKEGMLGTSACTENGVSGNCNIPICNGKEGKKGLSPGGVCVYYGHESEWHKIDWLKQYKTALVSVEAANNQTATIQRAIQKLQMLLHRAEEIYETTKVITEIKNNVGMSAFQNVSGNLTVHNATRARSYSHSFPPYSMPLWFLLLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGR8</accession>
    <name>F9WGR8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 534</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002309">
        <property type="protein sequence ID" value="CCD16505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14230"/>
    <dbReference type="OMA" id="WLLFLDE"/>
    <dbReference type="OrthoDB" id="1263366at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37354" checksum="A4C369D9E4DDAED1" modified="2011-10-19" version="1">MRRSCLVCGRLARDRLFGTAAISKRQLSCPVTDPPCDAGESTSLLAQQLLHRHRERQQVQRVQGSSCLYKRDPAVDALTGYGKTAVMARLAHTTDVSEFGVEKLLKATDGEWEGLSQRGKLSAANLAAKCAWDTMTVVRGAGCVRASGRHLGLKGKKGRENGREKAGGQNGFSTEFGSVTQRYDAVVPSDSSRQKTVASLSASRSWQVNMPVSLTHGGTVRGVTSRKELLQRQCEWRRVRDVLLSGRGGVPEQRSHNPMEESREDKSNAPAVRSFYLSPMFQRYCCRFGSGRVSSEAFMADPMMYHVLDSLDVAGEEELAGVQNKVEKLCERYHGECHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS2</accession>
    <name>F9WGS2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002310">
        <property type="protein sequence ID" value="CCD16509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="14337" checksum="3622C799AB2DD427" modified="2011-10-19" version="1">MYKRKKRGSGVERKKKEEKQEALHKSFQLTTGTHYSNYFQKHIFSFFSVSGKLLHAAISPLDAVPWGLVVFIIISSGDSEHGKGKCRFTKKEQQQQQQRNEYKEVPRHSKCYVTSAFRRPEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS3</accession>
    <name>F9WGS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 536</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002311">
        <property type="protein sequence ID" value="CCD16510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14280"/>
    <dbReference type="OMA" id="RANDTTH"/>
    <dbReference type="OrthoDB" id="380051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1654" mass="185549" checksum="8B44661FCB036798" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT1</accession>
    <name>F9WGT1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 543</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002318">
        <property type="protein sequence ID" value="CCD16518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14360"/>
    <dbReference type="OrthoDB" id="1693017at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="27236" checksum="8623A873D4CA57D5" modified="2011-10-19" version="1">MGVKNPPVQLLPVEHVDGIEAIFLEGIQSPEQINLYEFLEPLCTVFKHDYNGFTLGDFLRDPARCIHGAFFRKELIQKLLLLMTRLRIHTLVTIRHLTWRNITTLRDWANRREHTRIEKIPQRMLRYAASPHPPSSPSRPTPPPKATFYWTPISALIFLVSIGRYHRMDGWIGCGRPGSDRCLRWGVGTGISCQSPSPRPRSEVYNLKMEPARKGVLQNSLKNPPDTYSIRKRKSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH81</accession>
    <name>F9WH81_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 612</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15770</name>
        <name evidence="1" type="ORF">TCIL3000_0_30670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000592">
        <property type="protein sequence ID" value="CCD12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002394">
        <property type="protein sequence ID" value="CCD16670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15770"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30670"/>
    <dbReference type="OrthoDB" id="671700at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21294" checksum="815F9E36CEEF4BEE" modified="2011-10-19" version="1">MSFYTITSPRTIPWSMEKDVVDVLLDGVTYADRINLYWFLRPVLAGLPVDLVFFTLRDFIRNPRHCIPESNVCDALWQYLPYILWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRSPPPPYQPYQGVVLVEAAPAFIQVPYSTVGYLVPLPLSPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH92</accession>
    <name>F9WH92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002398">
        <property type="protein sequence ID" value="CCD16681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15880"/>
    <dbReference type="OrthoDB" id="1719083at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17009" checksum="A82CE03C3A8F4504" modified="2011-10-19" version="1">MHLVCPVAASWPRTQKGLPFVEATGGVEVRTGACGQATAPRMNFRLPCHVHSEMFFSNKACGCCAWLTCTFRTSSNKTCGVLWLKQELFLCIHICRSLRHGILILFPSGSCTVFVTLVAFVFRYPSLAKACLITFRWIIVVYSMREYPCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN1</accession>
    <name>F9WHN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_01840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002464">
        <property type="protein sequence ID" value="CCD16825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01840"/>
    <dbReference type="OrthoDB" id="1668909at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395063" evidence="8">
        <location>
            <begin position="25"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="100"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="388" mass="42432" checksum="D17E9FD19E5AA6A2" modified="2011-10-19" version="1">MATEAHLIWLFPACVLMLCLEVTCENKRQAIPTEVGESICSLSNKLKDVAPWTVGQVAALKKNRDEYASKFLDWKLHFHGSPECGENESILEEILKVLGKVNKEIKTLPAKAIRAGALAVKSAGRLDEFITIFANAQKTELLKVNYCLGGGDSPAKRRDLFDCFPTGGSIEMGEANLAKIPESMTDLREPNLTAVIENINHSSVAEYVRRKYVIDSEAGCNLIKGTAEGIVGGLSGPLWWGGGILTIGKAFDGDLKTNGRKFDAGEITRDKSSEDKALWTASPTTVPHLKKALAAFQDFKDATARIAQKFTEIGRIEKQIKPCLSNETMDEVHTQSCFKSAVKLNAELQAANALLARYYKEKGPLPSGSGLILRQSVFDVWYLIAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHU9</accession>
    <name>F9WHU9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_17770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17770"/>
    <dbReference type="OMA" id="TACNEAS"/>
    <dbReference type="OrthoDB" id="524818at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="13"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="865"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="128"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="895" mass="97104" checksum="4F103E89BF2B13C5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIV0</accession>
    <name>F9WIV0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27756at199999999"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11694" checksum="C541D1C63D2F47C1" modified="2011-10-19" version="1">MKPLTESQSYPAWITYIFTCIERQIRKEKMKSFEESQMPNTCQSTLLNHVRPAPRKKLGRLSESLLVQFRTGTSKHFGRHSRVLTQESQSIRLQMVLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIX7</accession>
    <name>F9WIX7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 844</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002652">
        <property type="protein sequence ID" value="CCD17276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21090"/>
    <dbReference type="OMA" id="TSWEMIY"/>
    <dbReference type="OrthoDB" id="1654336at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="900" mass="101204" checksum="390598B012E13AA5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ35</accession>
    <name>F9WJ35_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 866</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_21620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002677">
        <property type="protein sequence ID" value="CCD17336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21620"/>
    <dbReference type="OrthoDB" id="1441774at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRMBL" evidence="2">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="34128" checksum="B551FFA8B81CBEBD" modified="2011-10-19" version="1">MVPMAAVLYGTLASACGHPRRRKGDDLDEDKSLGIAREVLPIGKKKFLDLKQFDCVLCINPTGWTGKPSKQKISDRVVSFKVPYSEHCSFSELIDFVSFVNPRVVIPTVSLKAFQQHESLFVEKAPQLRSRYSNVQPLMPFLTKVPKLSESRMSVMAGAADATAKTEKQRNPFARTKDTTLTLTHSLNPSERERKGEVPGPRGLSQSGWSGSTRIHQETRDHHTAKENIRKINGMRSVNRTTLRSSPQCFSKPNSVEQPIRPDDVVTEKLSAAGTTTESSSWSPGNEDDDCFVVKINGPVIDISDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD8</accession>
    <name>F9WJD8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002713">
        <property type="protein sequence ID" value="CCD17442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22610"/>
    <dbReference type="OMA" id="YDIPANW"/>
    <dbReference type="OrthoDB" id="1358049at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016657">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="PTHR43035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="25054" checksum="940DB9A14E40FC22" modified="2011-10-19" version="1">MLAVSLACSGSSSDNQENISLRSYTPTLIITISAMRRTVYQLKSELPLPEDDVAQLVKDVVRECPSAFNSQSSRIVILFGEEHKKLWNITKDRLKANLSAEAYQEAIKKVDNCFAPAAGTVLFFEDRAVVEQLQQTFKTYADSFPVWSTESSGMAQYAVWTALATKGIGASLQHYSNLIREAVAAEWKLPATWEMHSQMPFGKALVGPGEKTYITDEERFRVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD9</accession>
    <name>F9WJD9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002713">
        <property type="protein sequence ID" value="CCD17443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22620"/>
    <dbReference type="OMA" id="QHYAHAK"/>
    <dbReference type="OrthoDB" id="830713at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="35709" checksum="7FA29E9E201A3292" modified="2011-10-19" version="1">MSNPRGHYTIEGLRAAGLLPAQMALSRKPRLRPHIGNLRGLVYPLPYYAMWRGNHNKYTYNKSTVCLWGEGDTRSMYHQHYAHAKCPTDYGRGGREFEYLTVQRGKLFQKPLPRVQYVLKDSKPTWLFKSWHTPLSSPTMWEREVQYAEHTPEHIGAKRPLAVVAPRTMHRHLFLMHMEKITITVSPLLFGYGHTIQKAVLDFYRRAISARSPFPNDKVFLLYAIDQITPRIEVTWLDGTSYVPPILEGASTQDLIQMVMEEAWLAADRMSAAGRVLNPLAIDDYKWDQLIVFKKVRDKEAGKASGTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG8</accession>
    <name>F9WJG8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002725">
        <property type="protein sequence ID" value="CCD17473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22910"/>
    <dbReference type="OMA" id="GGFYQRE"/>
    <dbReference type="OrthoDB" id="94130at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1646" mass="180119" checksum="41C06ACBC7BA4156" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH2</accession>
    <name>F9WJH2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002726">
        <property type="protein sequence ID" value="CCD17477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22950"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395113" evidence="1">
        <location>
            <begin position="25"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15807" checksum="4F5FD32ED4D93468" modified="2011-10-19" version="1" fragment="single">MCLELWGFLLMMATFAGVSLEVSASGDDLFDKLCNITKLSTALLSMDRNSGPLREAIYGRDDWAHFETSGRVKIGWHCNELKLRNTLCAHYTGGRHGLGQDGCFAESLLGTFLCICAPPGGGQPSFFCHNKSVPSGAGWSGRWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI7</accession>
    <name>F9WJI7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002731">
        <property type="protein sequence ID" value="CCD17492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02480"/>
    <dbReference type="OrthoDB" id="151548at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="301" mass="31745" checksum="AC1083B844BBFF4C" modified="2011-10-19" version="1" fragment="single">MGPKGRRSKPQESQSGRTKGTTFPRRESAHSADRPQDRCFALASQGPTASNAGNDSRANEGLHESGIILSVRSDESLPSNEARLSPSSLRVLDVVSGAVLCVRDGGPDPSFQAYVEVFLCASCASQSIVLATEVAASFDEKHVSVSAVKSTSPLTPFDLVVLEVTKNTQGCGGRSVSTEVTDATCLQVCAAFRRQYHGRLVFRGMRSTVYVKTAVFYVEVVQCTAPCSDDVISGCEQEGKAAEYGIMLNGTLIRHIASGSGYGGNVLSAVSAAVSGGAVPSHLLVVGXPGSEWSHFLCRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK7</accession>
    <name>F9WJK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002741">
        <property type="protein sequence ID" value="CCD17512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23290"/>
    <dbReference type="OMA" id="WRAMTIE"/>
    <dbReference type="OrthoDB" id="1400935at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="499" mass="55570" checksum="FBECB973D70A2DED" modified="2011-10-19" version="1">MKNKTVVSASIKLCFCAEAKSYSVHFTFSFRLFSLFFVLLATNCQACRNSSASLHRSLTSLFVSSCQPPPTPHPRGTHIQRVGPNRIRRRTHAFAYTHDRVEQEKKERRENSSSAVVVTLLPMLRRTLWCLLEKEPQIVRRAIMAKARPHPGGMHGTNSGSSNRATDVMWRRNGVGTNALQRSVDSAASPSGSRAPTILLGPGSSQQQRQQHNAAATARDVDKASNTASDDAYKFLLHHIDSEIAALTRRVTTVGRQRESVEGNQSRRIRQLFECIERPWLLLESIPPPQLPNKPLDVFAKEMYVRQHGTSTSAWEEDALFLSNCRRNWRVLSVQQRKPYEIAARRNEQTRKELKKKINNGCTYFEKLCEQTKEWTAEMVRGELRRVASGKSHAAAPATSGRSTLEANKPTVKGAGRPRTAGKKPAVKSRAEKKDPEVEVLTFEPVVKKKPGAGKKIGRPAKAAAPKSRKAGGATAVPKTAKKAPQRQGAKKKPKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK22</accession>
    <name>F9WK22_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab3 GTPase-activating protein catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_24690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP catalytic subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002799">
        <property type="protein sequence ID" value="CCD17683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24690"/>
    <dbReference type="OMA" id="CANSFEE"/>
    <dbReference type="OrthoDB" id="116501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043547">
        <property type="term" value="P:positive regulation of GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="PTHR21422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GTPase_cat" evidence="5">
        <location>
            <begin position="464"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="869" mass="98216" checksum="C758F35464B5BA2B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK33</accession>
    <name>F9WK33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 983</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002806">
        <property type="protein sequence ID" value="CCD17694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24800"/>
    <dbReference type="OMA" id="MESSECR"/>
    <dbReference type="OrthoDB" id="583857at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="464" mass="51907" checksum="6B90D814BF365E48" modified="2011-10-19" version="1">MESSECRQPHRDVMNGSLIMEATDSSNVIQEYVVTFIFLKDTTVADVLRDVNDKFQAVGLRLVIPLDECCFEVRGNAHSGAAASRGQSSIDRGCVRPIGTNEMGSSLIHGSERIYDSPVVRQLYCGNSSHDREQRVDFVVVRRNGSTVSARSVTSHHQVADVPPPRTISSLANNASLSQRLLQRKPLLGLPKEALKYIDPSSLSIDAARVDGVAIDDEQTSPDALSRVRKMVENEKKLVVAFGQDLHDKRHRSARGKHWSLLMKRQPSMEAFFKAVEDEKSAYENLTMEIERFTSRELADKEVERGALESTALYLRQCILEKKKRVEMQNAARSEIERLEKVLGDRRATKGRGQDNISVDTHDDYRQHLKESPSSTGNSSCSSSLGKKRAPNMPSSSRTEKASSPTRSNRSVYSMSTAPSCMFRSCRSPSVQDTYNRRVESDATSSSRSFKMYERAALSEARYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK56</accession>
    <name>F9WK56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002812">
        <property type="protein sequence ID" value="CCD17717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25010"/>
    <dbReference type="OMA" id="QQYATRD"/>
    <dbReference type="OrthoDB" id="1475785at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="279" mass="29308" checksum="DA7ED1661C6534A1" modified="2011-10-19" version="1">MHRAAATSVLSPACGTLIRRIAPSTPSHLSGRFPQPLADAGAAASLFSSMRAQGSYGRGGGNFRRGDGGRGGRGRGRGFAGGKAPVETSPRRVLMNQTCDGELSEGTRVVMRDDTKVLMHVIKHIPQNGAITVKSLNSQLSPDVQEAVSEKHDGLKNFLEQRKQLFIVKANPADGVLYVAATPLAYQKLTIRERQRETMQEMLGLGRRGSNGSRGGGRGRGGGRGMTGGGFRGRDGGSRGFGGSRGGGDGGSRGDGRGRFRGGRMNRGDGRGGGTQQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W353</accession>
    <name>F9W353_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1001</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_25340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000353">
        <property type="protein sequence ID" value="CCD11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25340"/>
    <dbReference type="OMA" id="WNTDTRT"/>
    <dbReference type="OrthoDB" id="794657at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="220"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="41303" checksum="DE774544ED2B6EB5" modified="2011-10-19" version="1">MHETVKLMTHVACCVSLLFHHLDTASLSTQCYSTFWLFALSWISAFLRENAGGGMAGRKQLEGIRSMTTAGSVEANHAQLIALLKAACARSPPCTHELCKVAVLCGAFCRRVAVLDAIPASDVARYCETLCTTINDVSSPMQITLFAYPLGEAESLRISRRLCYRQQLDNLTKNVPASRWDIERIACCIGGLSLFERAPVRSGNCRVPVKRIREGAETSGDGGAVAVRWQQPLRDPISLSVIKIPARGVHCQHREMFDLTAFVRSAQVVSVRRGDVLDGCSNPKWASNSGNAVTLPAALCPICGRSIPLKDIRVDEGITRAMAHYSDNGGTLSSDSTVVWDVATASYAVVGRSADVRSADVYVDSDDTILAQQLSTGVVVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W360</accession>
    <name>F9W360_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000356">
        <property type="protein sequence ID" value="CCD11568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25410"/>
    <dbReference type="OMA" id="MKSWDEY"/>
    <dbReference type="OrthoDB" id="307415at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="309"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="922"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1068" mass="115786" checksum="A642937AEEE2E814" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W375</accession>
    <name>F9W375_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000366">
        <property type="protein sequence ID" value="CCD11583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25540"/>
    <dbReference type="OMA" id="IAYNKWE"/>
    <dbReference type="OrthoDB" id="817160at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="518" mass="58797" checksum="5BF7CEBD8DE73B15" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W388</accession>
    <name>F9W388_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1019</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_25670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000373">
        <property type="protein sequence ID" value="CCD11596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25670"/>
    <dbReference type="OMA" id="EHDHRLK"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="7">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48234" checksum="444110D098179EF7" modified="2011-10-19" version="1">MPRSEMARTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRMFKQSMERAKEEAAANPYATFGVTQFSDMSPEEFRATYLNGAKYYAAALKRPRKVVTVSTGKAPPAIDWRKKGAVTPVKDQRKCGSCWAFSAIGNIEGQWKVAGHELTSLSEQMLVSCDNMDDGCQGGLMDRALKWIVSSNKGNVFTEESYPYDSTDGDVPPCNKSGKVVGAKISGLINLPKDENAIAEWLAKNGPIAIAVDASSFLDYTGGVLTSCSSDALNHDVLLVGYDDSSKPPYWIIKNSWGKKWGEEGYIRVEKGTNQCLMKEYARSAVVSGPPPPPPTPTFTQELCEGAECQSKCTKATFPTGKCVQLSGAGSVIASCGSNNLTQIVYPLSSSCSGFSVPLTVPLDKCLPIVVGSVMYECSAKAPTESARLMRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D8</accession>
    <name>F9W3D8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_26140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000397">
        <property type="protein sequence ID" value="CCD11649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26140"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="497" mass="57597" checksum="C1D3CEA8C6DB2F69" modified="2011-10-19" version="1">MVENTTEKEVTDDDEDEEATAKKGDEGEEPKVEEVKEGEEDGKKKKTKKVKEVTQEFVVQNKHKPLWTRDPKDVTKEEYAAFYRAISNDWEEQLATKHFSVEGQLEFRAILFLPKRAPFDMFEPNKKRNNIKLYVRRVFIMDNCEDLCPEWLGFMRGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALELFEELMENKDDYKKFYEQFSKNVKLGIHEDSANRKKLMELLRFHSSESGEEMTTLKDYVTRMKEGQKCIYYVTGDSKKKLETSPFIEQAKRRGMEVLFMTDPIDEYVMQQVKDFEDKKFACLTKEGVHFEETEEEKKQREEEKAAFERLCKTMKEVLGEKVEKVVVSDRLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSAYMMSKKTMEINTTHAIMKELKRRVEADENDKAAKDLIFLLFDTALLTSGFTLDDPTAYAERIHRMIKLGLSLDDDAEEEAAPVAAAPASADVGASSMEQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P5</accession>
    <name>F9W3P5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1087</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000448">
        <property type="protein sequence ID" value="CCD11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27150"/>
    <dbReference type="OrthoDB" id="1709447at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="20245" checksum="CDBB9B0CC4969142" modified="2011-10-19" version="1">MNQVSLQTLQASPVGRCIILRGMYHLLMCVGCWNPSLHTGDLAYFDYTNVLATPCPTRHDAPLYDLTRIWRHFFSSSSCDHSARMYHVINRVVEIRRHTACPSKSAYDLRKGMLCNPFLLGEVPHFIPKLKLLVDMENTAPHFREECKAARFEDKADKERLKQNKPKKEDARSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X4</accession>
    <name>F9W3X4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000489">
        <property type="protein sequence ID" value="CCD11852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="16103" checksum="05BE4C590AF4550F" modified="2011-10-19" version="1">MVVSTVMGRDPGNNAFAVEPQKLKLGRALEKRQVHVEHQKARRLKQMGERGWRTVAPLSGAASRDIKRRVAGHWPQPFTRTRSFIGMRRSNAKAEQHLADTTDATHREMRKVVHATKLSRVLFWPPIPPIKWVQKQKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W408</accession>
    <name>F9W408_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000500">
        <property type="protein sequence ID" value="CCD11891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28290"/>
    <dbReference type="OrthoDB" id="1712811at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388636" evidence="1">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18093" checksum="BFB80F9083292628" modified="2011-10-19" version="1" fragment="single">MSSLFVCGYSIASLMSSILTRCWSLTVCIRRSWLYNCISGCSCSSDMPTRRSFPTPPCKPDPVMPVGGTHANVPRSIVWGDTPFNIFHLTPECTNFLLAPGFPECEYRLHTLNVALESLSKRIHPHVSHHPCPAFHGAFHPLLCGHTHIEQSIALVTYHSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W497</accession>
    <name>F9W497_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_29110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000532">
        <property type="protein sequence ID" value="CCD11985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29110"/>
    <dbReference type="OMA" id="HLASTTM"/>
    <dbReference type="OrthoDB" id="1327889at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48357" checksum="8179AD70E53F4A5E" modified="2011-10-19" version="1">MEELQRLAASCKAELVGRTQHWMAKLDGAFSNGATMSLQALRSAGVALFAFCLASVAAFVILSACVAASVFGSLLLRQYILLLVPGNELTTLDFNTMPLETERWRLHDLSQMIAQIDVTPSDSSHGASTILTNHGAERDERHTSVLRTEGDTLKMSLISKMVYGTVATSTLILPSPVRGDVFHADGSVSTEALFSQRKPMFHAKGVYNAKMQLVFHKEDVGRDISLVLESVLLMANESYVPQPLRSLRELLRMTSSFTITTGRKFGSWPRELLAESLHAAFCFPIWIFQTLSDLLHSDVFPVIDRATEVAVVTSVYTNFEPPLHLQPRLRAINFTLYHSEGDTSSKPRLKRALFHTSVELKGLAYYFSTYTISSFIGVTIFLLTLLGTGALTFAVAAGLFVVLPRLRNTAKCGGQKPLGRVSPAASHDGRVMAPKEEADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4L9</accession>
    <name>F9W4L9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000578">
        <property type="protein sequence ID" value="CCD12113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="15140" checksum="9AD3909BF60320B4" modified="2011-10-19" version="1">MSLPHIFHYFFFVAAFHWYYIFVCSFFLXELRGSKEIEIYSGESHVRNCLLLFQLCGYYYTFIRFCCLSFPPPHAHAYLPPGLYTFLLCVTTHTRTPLPHYFYFLSLCDGCVCLFNRVAQLRSLLDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U5</accession>
    <name>F9W4U5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000606">
        <property type="protein sequence ID" value="CCD12190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30960"/>
    <dbReference type="OrthoDB" id="4484at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="961"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1105"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1135" mass="127830" checksum="4F7FD4D12433F6AE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5A5</accession>
    <name>F9W5A5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000686">
        <property type="protein sequence ID" value="CCD12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32390"/>
    <dbReference type="OrthoDB" id="1661843at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="465" mass="53698" checksum="4BD2CD0C9113F494" modified="2011-10-19" version="1">MSARKREQHQDPQGQIVPVQQINPVVHEPQTQGDIQLEQHLFSAPEIPEQQPVPIKELPYGKWKKPGYNYMHDGLAPTLPYHSEDHKLRLSQAKQLDAVNNSSRFTQLCIEYPDATETNRSSRDGFPPRFLRLTRNAEEQRPLQINPVPIGTVVQQPNGMPQIITDPSKSKRLGIKVLEGEIANRRMMNLHNARTQLRTFQSVQTDIEFTDEMQVALRTFNGTLYILERYGPAITMEGILKAHGADWSKHLEWLGNKTPTETIGHIAQGRIDQYRSAYQAACFWADHHERTIYGLAGPLGETIEPFTFEDYDNMFSVFVTYVLTVIGKIHAGRVIDPKEIRARYAEGIKDELQQTIDDHINSFVKHKYSRKSNNSRPMIPWGTRVASKNYYIGSGRRHRTYSTESRKGKNIGQQYRKYQKQDSYKSLRRTQRAKTRSQRRRTGTPKPKNAKERVRFAETPPRNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J0</accession>
    <name>F9W5J0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000718">
        <property type="protein sequence ID" value="CCD12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33210"/>
    <dbReference type="OrthoDB" id="1710296at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19115" checksum="69688F0760E4CE7C" modified="2011-10-19" version="1">MEPQLFYQKLHSFKAGCQPHVSGLASCRHVMIYFSFYSNQSGKFKPFQYKTEPLMVSALIPFIAPAAICRCAFTLGCTFRYNVVGSFFPLTSNILTGACFIHTDSPSKQTDKYPSSSNKCRPYGSHISVPFTRAHPFRYAPHSQLPVKLLLPMDGSAMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W607</accession>
    <name>F9W607_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000806">
        <property type="protein sequence ID" value="CCD12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03540"/>
    <dbReference type="OMA" id="LRAKSHW"/>
    <dbReference type="OrthoDB" id="916529at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="645" mass="72446" checksum="3360BC82AB46253D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E9</accession>
    <name>F9W6E9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1453</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000855">
        <property type="protein sequence ID" value="CCD12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36080"/>
    <dbReference type="OMA" id="TETSHXI"/>
    <dbReference type="OrthoDB" id="194786at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="449" mass="48549" checksum="4A15F2FF34BB9279" modified="2011-10-19" version="1">MRGTSAATVYFAVEPYMLLGNQSGDIILFSVFKGKTVQRLNSSGAPGENSPAKGGVTDPCPKQRVSAAVSCIVEVSCGAEKRLTCLISNARASRERVKKSFTAPSVGAAGMPPSVFAVGFDDGQVLLLHITGEGAYLSRHITIFSGSPVRKISMRTPSVFSRLWRAPQQEEWGNGCREHSSLLNVVVVPAEIVVFNKDGAIAAVSSCGGALCLMKMPGMEEEVCRVTAFESNTAGDFLSLQWVPSHRDAALLPDLLIATNEDDSIGVYRFVKGKRDLTNGAERKLSWSSEGPSLVLGIDRQDSTLSTDTLQSSLMLVSRCSFHHSWVVDLCTLPHQNGNLLIATSYDRRNSFWPIGYSDTPPDTSVDWPPRCGGYETLLQRYSSTGFVRDFGSALRNDGCTFPTEPAAAFVMHKGAVSRCITGGTETSHXIVSLCLQGFVKFWEVKCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H9</accession>
    <name>F9W6H9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000873">
        <property type="protein sequence ID" value="CCD12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36360"/>
    <dbReference type="OMA" id="LYTKRKX"/>
    <dbReference type="OrthoDB" id="138195at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23079" checksum="78CEC34D8E920B5F" modified="2011-10-19" version="1">MVDIEAGDILIEGHPIRSYRLRKLRQLFSVIPQDPVLFNGSLRDNLDPLHTSSDAEIFEALRLVGMRERIATCSGGLESRVVEGGSNFSVGQRQLLCMARALLCHSCKFVLMDEATASIDPALDKEVQHAVRHVFAAHTVITVAHRLQTLAGYDLLLLLRDGRVVETGRPCDLLLDRASHFSRMVSAMGEESARAFAAAVEEGSRTREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R9</accession>
    <name>F9W6R9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1513</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000922">
        <property type="protein sequence ID" value="CCD12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37150"/>
    <dbReference type="OrthoDB" id="1731230at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="18322" checksum="C19B767B178D4824" modified="2011-10-19" version="1">MLVLMKTRGFVLSPPRSVMTAAPMAAVILWMEIALASEGIEGHSVMIALQVITVQSALSAPSVRMGVNVMMVGGGRVVANVMLHTVEGLALSFARDLLIAVLATPLGDTVHAVCVVVTKNLGGAAHIATLPTIRAVGYHFLGVKHAAATRLTGAPFAVTWCATLRSSRVQKVSTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6W1</accession>
    <name>F9W6W1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_03800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="CAEQ01000942">
        <property type="protein sequence ID" value="CCD12918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03800"/>
    <dbReference type="OMA" id="HSCMCRC"/>
    <dbReference type="OrthoDB" id="741207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="60"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="45691" checksum="4866ACA3F036E99B" modified="2011-10-19" version="1">MPPYSSYCMRLPHEWLNCHRIFAYSVVLGSMDNPKEIDTSSGGRRVYFVQGQTFEVSRSHRLMKFIGSGSYGSVCSAIDEDSGERIAIKRIPRVFSDLREGKRILREMDILTSLHHTNLIRLRQFIRPCQKDDFSDIYMVMDLYDTDLHRIIKSRQKLTNEHYQYLMIQAFRGLFYLHTAKVMHRDLKPSNLLVNGDCTLAICDFGLARDDLWTPSSALTEYVVTRWYRPPEVLGMGSQQYTNAVDVWSLGLIFAELMVGKTLLPGPDYIHQLIMIVNFLGTPALEDMEFLSDEAKNFLLAQPFQEARSFNVLFPMATPEAADLLSKLLVFHPDKRLTAKEVIEHPYFAKFRNPAAESGATEPYVWRHNDNLTVEGLREEMWRIILAHSPDPQVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W715</accession>
    <name>F9W715_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="5 12">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TCIL3000_0_37920</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="5 12"/>
    <dbReference type="EMBL" id="CAEQ01000962">
        <property type="protein sequence ID" value="CCD12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37920"/>
    <dbReference type="OMA" id="SCKFAFG"/>
    <dbReference type="OrthoDB" id="838642at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027250">
        <property type="entry name" value="Pgk_euglenozoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500126">
        <property type="entry name" value="Pgk_euglenozoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="375"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="44913" checksum="16351855EC184061" modified="2011-10-19" version="1">MTLNEKKSINECDLKGKKTLVRVDFNVPVKGGVITNDYRIRSALPTIQKVLNEGGSCILMSHLGRPKGISISEAAAVRSAGKVPGYEEAATLRPVAQRLGELLSKPVVFAPDCLDAADVVKKMSPGDVVLLENVRFYREEGSKKEEEREAMAKVLASYGDIFVSDAFGTAHRDSATMTGIPKVLGHGAAGYLMEKEISYFSKVLGNPPRPLVAIVGGSKVSDKIQLLDNMLQRIDYLLIGGAMAYTFLKAQGHRIGTSMCEEDRLDLARSLLKKAEDRKVQVLLPVDHVCHTEFKAVDTPVVTADADIPDGHMALDIGPKTIANYVETIGKCKSAIWNGPMGVFEMTPYSKGTFAVAKAMGDCTQKNGLMSIIGGGDSASAAEQSGEATRMSHVSTGGGASLELLEGKTLPGVAILDDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W748</accession>
    <name>F9W748_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000984">
        <property type="protein sequence ID" value="CCD13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38290"/>
    <dbReference type="OrthoDB" id="1711126at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388753" evidence="2">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20557" checksum="4CDE3CE643D32329" modified="2011-10-19" version="1" fragment="single">MGPGSRFALLFLALMLYSMGGDGHPGISRKKYCQSVRMSVYLLNHRFSTAVHHYQNAIEVLSIAKKKCAEIISENGKPKEVLQENIRRSNFLENHHTAVTEIERQIMTEEKKLQSILETIGRTCNAWVQTMPLTPSLRKDIRQQLAEAEIITKDVEKLGQTSTKHASTTTNWTAPESNLMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7M3</accession>
    <name>F9W7M3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001052">
        <property type="protein sequence ID" value="CCD13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1122256at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13346" checksum="DDBED9211FCF750F" modified="2011-10-19" version="1">MQAVSAVNMRRFIVTGIGLCYHQIAQEECASGGDGREMYGRALDLLVEALNVHIDENDHEYVKLTLLGIMKCFDGVGDGSQAITTAEKLVRWCTRRCDEEGIVNGNEWYVKMKEKYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N6</accession>
    <name>F9W7N6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001059">
        <property type="protein sequence ID" value="CCD13207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39770"/>
    <dbReference type="OrthoDB" id="1665251at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388774" evidence="4">
        <location>
            <begin position="24"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="94"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="430" mass="46385" checksum="0A2073F6CABA39ED" modified="2011-10-19" version="1">MAFFVNLLAVSVVTCSFIKHAVAQNAQVQNNDNSEQFALLCRIYNVAKNPPINHVDLQDPNKIVEVIDSINASFAEEKQFNETNQVENSSGVQLKPTTTREAAVAQALLSRITRKAHTILDEIRKLNATRDIEKVKAEFAQVIFGGGMNESDLCDGVLKGVGERGAACGSSGLSHKGNYAGKNLVVDFFCLCSMTRDNSNGIGSVCGVEVGGKGGKKPDNHGWGAANGPSGSSSMWASVKKGCGNLLHHHPNSTKEGDEVIEDFMRHLKSGGLYRWGASNLVKGSGRKSGMLGTGAGTENDGNGDNLTCDGNRGYTGSNGRSGKPPGGICVYYGPQPDWENIDWLKKFRDALKTLDALNNKTATIQRGIEKLQMLLHRAEKIYETTKVIAEVQNPAQHTSIQTAAKRLTAYSGARRHPIYAHSILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S2</accession>
    <name>F9W7S2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001073">
        <property type="protein sequence ID" value="CCD13244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40130"/>
    <dbReference type="OrthoDB" id="1666418at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="390" mass="43840" checksum="9AD0039F907A35E9" modified="2011-10-19" version="1" fragment="single">MALLLDLSFGVWGKVLEAGKMRDTRIIGKEKGKGVWWSLLLVTHWGMGMKGVSGVYTYSSGTIFNGKEHDALCSVFQSGLDLWNASRNSDLKLASGLESALGQALFGKSRGGQLESIKEDLPQEYQNPGHRGQMCGRCWNSERYYPGRSITHDLLCLCTAGQYGRPYYGHFWLFGWHPKETSFKLCGKERANMVENENSGWHAKTYYKNQQAKDLDKTWRTVVWGCYNSWKSKAVQGSQNLEERLRALTGAMENFTNKLTIDRNKWHKLGGFEEHTESDGSDERHIHVRYGPCNNARKPWWRRLQEALRGKTPSQLLLEPSVASSQVTRSEHEADGKGEEEDFSEMEEGEGHMEPGETTASGDANHTGAMTQNSHGSHSIRTTDTHAADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V8</accession>
    <name>F9W7V8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_40490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001087">
        <property type="protein sequence ID" value="CCD13280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40490"/>
    <dbReference type="OrthoDB" id="913121at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="SSF160104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="34047" checksum="14BC2E037912C527" modified="2011-10-19" version="1">MPSPNDTTHIDIAGQQVPVVKGGLYDRFRSNPPLSVVAAELPGVDLSWFKGLQKHKVDIGFESYSPNFYYQNSRVTAVYTADIDKLRALMPPQVLAAVQPLQVWPGRGLIAFTAYTYEHCDNDAYNEVAVSIITNKPGKANLGPFTLVGQSMSQDFWGYVLKLPVNTELARVRGVVGYNLPKWLTGIDRKEDGHSVVYDITDSQTGKLDVSFKAKKLEKLSHDADLVTSSFTNLDHHGQLAYGYAVSRQLSHGSSRDADSATLTLGDGSLSNYLRDLKLGKMVKYEYVPEFQSALYAPEPLVNLIGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W832</accession>
    <name>F9W832_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001127">
        <property type="protein sequence ID" value="CCD13358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1655275at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="787" mass="88896" checksum="9E8DD4C71A279AC7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W849</accession>
    <name>F9W849_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1705</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001136">
        <property type="protein sequence ID" value="CCD13376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41330"/>
    <dbReference type="OrthoDB" id="1725425at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="18206" checksum="3F1F716A34B14E9D" modified="2011-10-19" version="1">MGQTEPLLKKQAADKGVLRAEKENVSEKKDSPGTCNFSHSHDTQRQRGGFEDQLGRKVPDRYKKNKDAFIYIYIYRKKETTLERANTKYIKLRLNNHHFVLNTPIIYSITFTPIKHQIVQLMVAVQSISHCTQQEKEKGGERMNRRKTAEKKESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W895</accession>
    <name>F9W895_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41760"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389939" evidence="5">
        <location>
            <begin position="33"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="79"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43339" checksum="FBD34C85CAA01C9A" modified="2011-10-19" version="1">MMKLFMVCLVVMGSWVGEWGVMANAKVSVVEGDNSEYFKLLCRIYNVAHNPPIKPVDTKDYQKIVDDINALSAAANGKERVNTQSEETKSAQTQLIGITREAHKLLDGIKNVNPEGEVERARNTFNQVIFGEHGKEGDLYHGTLNVGETRSKACGSNNQGKGTSAGKNLVVDFFCLCAKPNLGDEVVDNVCGVSVGSGDGAGWGLKLVSADTMWNEVKDGCEKFVKQSVTSTQDGYFSLSIFMDRVAVGGNVKLKNKDTLRTPSVLGTAVSDTGTINFNCNGKASVMRVGRAGVCVFYGNQHQEENIDWLKKFKTGLKLIDKLNTETASWQHQLTTLLNRARELYEKVKANTQLEEVDMEEPIAAQHPNPDENENADSATRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F6</accession>
    <name>F9W8F6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1732</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001167">
        <property type="protein sequence ID" value="CCD13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42340"/>
    <dbReference type="OrthoDB" id="33681at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043232">
        <property type="term" value="C:intracellular non-membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099080">
        <property type="term" value="C:supramolecular complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="PTHR12609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="1">
        <location>
            <begin position="267"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="763" mass="85439" checksum="81805399D5C0E8DD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8M8</accession>
    <name>F9W8M8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001186">
        <property type="protein sequence ID" value="CCD13562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43040"/>
    <dbReference type="OrthoDB" id="1619804at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="246" mass="26142" checksum="90C6EBE10037D9ED" modified="2011-10-19" version="1">MFPAGTPIGPAAVFPTAVQKRPIVVQQQQRVVPAFTQALGMSQMVQPFVQPAPSVLPSTTASVQRVKASSPLVGGATVAPTGYVQLLAPVQNIDGSTSYQLVMMPANQLAQAAGTPAQVAQNPGAAAKVSQQLQPQQQQAIQYVWKAPNAKIQPQQMVRSPQLVAPQYASIAGQTQGFALVSPAGQQQCVMAVNANQVYQLQQTYPRQQMQPQPSPGRPVIFTGQHPQQQVLATPVMQSTTSLMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8M9</accession>
    <name>F9W8M9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1751</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001187">
        <property type="protein sequence ID" value="CCD13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43050"/>
    <dbReference type="OrthoDB" id="23800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="PTHR16453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="239" mass="25446" checksum="103B44CB7020A4D2" modified="2011-10-19" version="1" fragment="single">MKPIASPTFHDVPQAPITVTKRPNCPSLSSSPSTATPKMNNIKTHSAADFVRGRVTLSEGLTCVDFHPGHNLLAVGCTKAVHILEVRLLTHGSCYSTPTAGGSGCRGGQSDTHLTPQSTGHMGLRQCGMFSNISKVEAAVWYPQPNEDVLAFVQRSRNITILFDALTIKAGKRMAKQWIHNAVGRCLVSPIEAGGGLLSTAVMNVSNMSCTPVSGSAPIDLMHSAPFARRDKVGRSMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8V9</accession>
    <name>F9W8V9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1787</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_43830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calflagin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001227">
        <property type="protein sequence ID" value="CCD13645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43830"/>
    <dbReference type="OMA" id="FEYYEAF"/>
    <dbReference type="OrthoDB" id="1340191at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003299">
        <property type="entry name" value="Calflagin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01362">
        <property type="entry name" value="CALFLAGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="248" mass="26820" checksum="138CB07F6C606B01" modified="2011-10-19" version="1">MGCSGSKAEPASKGSACPEKAPADPRAAWERVRALLPREKDEKSKLERIELFKKFDVNGSGRLSFNEVCSGCERVLQMHELTTRLRDIVKRAFEKAKALGTKLKGRGSSDFVEFLEFRLMLCFIFDFFELTIMFDEIDKSGDTLISKEEFTNAVPKLTEWGAVISDVEAAFAAIDANGTGAVSFDEFASWAATNKLEAFGDPDAETVAPPPEAGDAAPQAEGEAPAEGEAPAEGEAPAEKANEGEETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Z9</accession>
    <name>F9W8Z9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1805</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11850</name>
        <name evidence="1" type="ORF">TCIL3000_0_44220</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001247">
        <property type="protein sequence ID" value="CCD13688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002211">
        <property type="protein sequence ID" value="CCD16237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11850"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44220"/>
    <dbReference type="OrthoDB" id="1714074at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19970" checksum="45DD5D6936658AAD" modified="2011-10-19" version="1">MGEVAIPETWKRAMRRLVSSNKWLNDASSLEFYSVMICKQVCQARWHNSCEIRLHPKVRRLSKWSVSHLTLYTRPGFVWERLLLSCYFPLKVARWRLSRLSRGLACPSDPSALSRKALILAKVCVCEHVVKKHTSGPNTSPANHGRSGCGCFHAWLWSDVILRFGRNFNSGRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W915</accession>
    <name>F9W915_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394618" evidence="1">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12224" checksum="D1ABEEFA612344FD" modified="2011-10-19" version="1">MENVIRLLVLSVLVVVYAVANDKAGGGSTITLQKATAVCHIARKLKGVSTYVAQKLEEYDQKIQEIQMMRDVVRLKVFMPGGEKLNCGKESAFLLYVYERLAAMQEVMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W965</accession>
    <name>F9W965_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001273">
        <property type="protein sequence ID" value="CCD13755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44620"/>
    <dbReference type="OrthoDB" id="1405548at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002725">
        <property type="entry name" value="YgjP-like_metallopeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01863">
        <property type="entry name" value="DUF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF45" evidence="1">
        <location>
            <begin position="54"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="271" mass="31207" checksum="F82490C9C98B9111" modified="2011-10-19" version="1">MGGANHAGRFVRYMSVPIVTNAPHGPAAQCWLSFYYADELIQVERAQRGREVSRILIKVDPDCRVRVSAPAGASDEQVLAALKRRGRWIYQQLREFRAHLTHVRPRLYISGESHYYLGKQYVLKVVETPDELQKVRLLRGKLEVSVRVKSAGKVRELLHAWYKAHAREIFDRRLEAILQQTLWVSGKPPLRLLSMQTQWGSCSPAGRITLNPHLVKASRECIDYVILHELCHIAEHNHSDRFYRLMQQVMPQWERVKKRLDGMAASLLNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9D3</accession>
    <name>F9W9D3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001297">
        <property type="protein sequence ID" value="CCD13833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45290"/>
    <dbReference type="OMA" id="RMNTARE"/>
    <dbReference type="OrthoDB" id="1620652at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="18772" checksum="D96B428BE8570A6F" modified="2011-10-19" version="1">MVKFSAPASRNAVKKSLSNSSDAAVGKGSKGALASTVTAGTRKEERRGKKASASGRRKLMRGPSLTVAMKDDGNPTARPSVTTKGVVNSNLRGKRSALAQRRRAALRVVAREQSKARLTGAENRLSAVREELALFDQVTQVPSFVANPFAAISEHLDSTMEFLKPQTPSVGRAKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9G0</accession>
    <name>F9W9G0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001304">
        <property type="protein sequence ID" value="CCD13860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45510"/>
    <dbReference type="OrthoDB" id="1660181at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="612" mass="66808" checksum="1B778A0333A6A06E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9H2</accession>
    <name>F9W9H2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001308">
        <property type="protein sequence ID" value="CCD13872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45630"/>
    <dbReference type="OMA" id="VANGPPH"/>
    <dbReference type="OrthoDB" id="1522976at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390003" evidence="2">
        <location>
            <begin position="18"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="41294" checksum="1C8701A3772FCAD7" modified="2011-10-19" version="1">MALFTCFIFLLSSFTDSLRREYSEIMSSGAKPHPGEAFPIHSATVQPAYDPSMPPPPGGSQAAPPTPGKDHEIIPAAVHPAYDPSMPPPPGGSQAAPPAPGKDHEIHYAKVHPAYDPSMPPPPGGSQAAPPTPGKDHEIIPAAVHPAYDPSMPPPPGGSQAAPPAPGKDHEIHYAKVHPAYDPSMPPPPGGGEALPTDYYQHPLLPGYGQPPHVERSGGLANEPVGEGRNVVNEWKTGLLVAPCRQPCFCLGSCFCPCCCTFMQRKKLLQGDWSRYTCCAGICCEKTCCVIKKCEPCCLCLETCCCLGCALHGNRFMIREHYGLQNDCCDDILMCAGACCGILACCTEKKAVKSIADILFFCTIGCVLAQHEHQMKVCGYPRGHEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC0</accession>
    <name>F9WAC0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1953</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001412">
        <property type="protein sequence ID" value="CCD14181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48290"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="273" mass="29270" checksum="AF8D1C78CB041CC2" modified="2011-10-19" version="1" fragment="single">DVINDDLQLIESPTQLELDHEKGAASVNFTSGERTWDGREEVHVAEDVESDDSADSGLGGGSLAANSQSLSLANPTDALETGDSGRGDVVCGSSGTHVEEQQEKLLHPASSNEEGDRQKDSEGEGEAEDIDGHDEEENENEKSEECQDVDDRKSENEDNEVSIPEEAPDDADPPSTTACTDNSDSHEMIPVQCSVDDCPTSCQAEDGGKEEEEDEGAAQGEHEDEEQKPITPSDRSVHPDDDGDAVERVDVASEAQSDKSERENSTGDSERIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG5</accession>
    <name>F9WAG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001433">
        <property type="protein sequence ID" value="CCD14227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48720"/>
    <dbReference type="OrthoDB" id="1724326at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20527" checksum="F0AB9F1901B1E9EE" modified="2011-10-19" version="1">MRQEHSGANNLHLQRAAGMKVPNDRLTTVKYLLHVLQQWENKQSPSSQTKKNINVESFSGIFKYSSHKSKNTTIRYKLAKYTNITIIPITTRLPMAPSNRKSQSVCPINMLNNSKNNSQATRQVLPSLFVQSKRWKCSPKVIKYAFRVRSCVGYASHNYFLCSYSFFFFAFLIFNCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAL1</accession>
    <name>F9WAL1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1986</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001448">
        <property type="protein sequence ID" value="CCD14281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49210"/>
    <dbReference type="OrthoDB" id="1712813at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19591" checksum="5FCAD63B65C97950" modified="2011-10-19" version="1">MEKDTLNSQGGRAWTMDSTVEAVLERARDDWGAISATTFFSIYHVHRCVVVPNSPLTLQQYLKDWRKFVPDSVKGRRFRYRLWLMGALMRRHLDQDLARLRAAKVVTLEDWQREGDRVDIGPMARALLTDAFLHAVAPSSPSENYPLVSSLRSMRVRGTSPGFYFYTYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAP5</accession>
    <name>F9WAP5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2001</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_49500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001464">
        <property type="protein sequence ID" value="CCD14316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49500"/>
    <dbReference type="OrthoDB" id="1672901at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="221" mass="24642" checksum="2E102D88097B5C51" modified="2011-10-19" version="1">MVCLCTVGPGGWPLNVSENTLCGGDKETLRAGSGKGWGTVGIPSHHVEGKEQIQATWTNVTSECLQGGKEKGEELKDALNKFINTLVAKPSHAHPSRRQLGEGNPGEFYACTGSKTYGVCVMYYPNDKDTKTWWKDLQTAIKEDEEIQKQREEEEKRKQQEKVNDKDQPRAERLSATPTTTNQTEASKQDNLTDKLRRLNITSGTPISMPSSWLLRAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAS3</accession>
    <name>F9WAS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001476">
        <property type="protein sequence ID" value="CCD14344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13649" checksum="3EA89C36CE90CC21" modified="2011-10-19" version="1">MHIEERKTTFLRNVHVSSFSRGPAPMNSTPFTDTGDSIGVLTPPLVSPYITLKTHPQVHSTLKMPKHTCRGDGTTPLPWWGTPSTPGGNAGPGYTSSLKTETAPLGGLSKRGEEGYPKIFYPKIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX0</accession>
    <name>F9WAX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001492">
        <property type="protein sequence ID" value="CCD14394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50110"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20101" checksum="B5816A13ECB2C91C" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNLGDPKKINLYPFLQPAYPFMHSYVSRFSITDFARNPWRCVGEADGREQVWEQFPRLLWQFRVLALKLVYYAGTPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX1</accession>
    <name>F9WAX1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_50120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001492">
        <property type="protein sequence ID" value="CCD14395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50120"/>
    <dbReference type="OrthoDB" id="1679583at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394646" evidence="5">
        <location>
            <begin position="26"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="39544" checksum="EA316ACB5AB428A3" modified="2011-10-19" version="1">MTRMMMMKFWMIIIVSMWVSANVEGTDHNHDAHGVLCALLRVAVKKWEEVKDRQHDDTLKKALKQTIFGNESEKDMEEFRSQLPDAYHDNRKTKEDRTLWCGQPFDDDHQQSNANQPRWPGHSAPHDFVCLCTVGHGGSPLNKSEGSNQDTLCSKNRESLGGSGGKGWGDIGHNAEPQLRATWENVISKCLQGSEKKGEELKENLEKFMKQLKPTTSTLNPSRRQLGEGTPDDTHACTGSNATGVCVMYYPNLPPIPWYIQLRNALPEEEKFQEEKKKREEDERRKQKEEAAKKDTNKNEALKSATTATNQTEQNKTATLHETMHKLNITGSSSISMPSSWLLRAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB42</accession>
    <name>F9WB42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2058</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001528">
        <property type="protein sequence ID" value="CCD14473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50830"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17336" checksum="BEFCE6272C1A6EC7" modified="2011-10-19" version="1">MRELETGCTYKPLIPNFPLVDGFFVVEGVGPNTIVLLQVTKAKEHHTKRTTVRKFRQCMGKAFECREKVEKACSWEIMNVQHVDSGSIKKRWKCCTSGDAAGDEHLALWENTHQYRVSLNTDIASEFISRGSCWRRDPIRRVRQSRAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBK8</accession>
    <name>F9WBK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001592">
        <property type="protein sequence ID" value="CCD14641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52410"/>
    <dbReference type="OrthoDB" id="1657483at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="591" mass="66767" checksum="CC8D55D5C749ACE3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBL3</accession>
    <name>F9WBL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001596">
        <property type="protein sequence ID" value="CCD14646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52450"/>
    <dbReference type="OMA" id="LIMISIN"/>
    <dbReference type="OrthoDB" id="1609889at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="22477" checksum="3468D52C406AF80E" modified="2011-10-19" version="1">MEQLYIRLGVFVFIYMLTFYILFCFILIILLINFIYFYIIFIKILLFQSCICVIIGLNSFAIITLLFVLSVNNFCFLFLIFISTKNYIFYLYLNFHLIYSISLVLLIILYYFFIIYNIFDIKYNENYFLINFIFFSFFNNFLISLLLACLFLCIGAIPIVFGFFIKVFCLLLQLSYLCICIGFFFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBM8</accession>
    <name>F9WBM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001599">
        <property type="protein sequence ID" value="CCD14661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05520"/>
    <dbReference type="OMA" id="IACASQA"/>
    <dbReference type="OrthoDB" id="1055094at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="319" mass="33103" checksum="FE4331D05A376E2B" modified="2011-10-19" version="1">MNLADALNSARSPITKSIFLIVSAVDGAEAGEGRLWAPCNQDRSSAVSIMSTAGWLAMCKDHEEPTVVEACYGNGAGGFLTVKCVPMDDTYLVMIVQRGDGENLPAPISTTFSIKEEPLVSLLGAYIAGDDTTTPSKWNSVSAEQAVKSLRCSLSRSIACASQAHGSEKTSSVVAPVEVEKRESVLPRSVQSGIPECGPAFSPPTGVTGSSALFAGLVPRPVGFRYGERDLLPDGGSGIGVGGGMALGSDAFRGANVPYARRDPIFPGDRPRGGHFSCPKAPLLPGEPDPDHLIPPGGLAFSSCFGPGRGTNFGPPFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP2</accession>
    <name>F9WBP2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001605">
        <property type="protein sequence ID" value="CCD14675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16566" checksum="0B0F6B635547D283" modified="2011-10-19" version="1">MCHDEKGSHVPPLSAKKPHPPTCNRLDTPISSARQPQPPHTHNSSMGFKKVTHCEEADRLQEEPMLPGLLVTHESLIKCGWWRGTRRAPLSPRFPLLSRSEDPPGPSLVRRGRYILRAASPSGGLLRWRPNIPNGNLGSDRDGGRHTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ1</accession>
    <name>F9WBQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_05550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001610">
        <property type="protein sequence ID" value="CCD14684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05550"/>
    <dbReference type="OMA" id="ANTHTHE"/>
    <dbReference type="OrthoDB" id="500018at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1436"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1503" mass="163964" checksum="0E71AB22D708597F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT1</accession>
    <name>F9WBT1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001623">
        <property type="protein sequence ID" value="CCD14716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53090"/>
    <dbReference type="OrthoDB" id="1694201at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="223" mass="25339" checksum="1D61C621997D23AA" modified="2011-10-19" version="1">MHAYKSCHTKLLPFIQARSGRLEQGLDEGTRQYRARHRSDFYGFLVDRPIFQQNHLGVVQLDQVALEMLLHERALELQVELDVLKGFRIGNIKLRFFQKLLHGHRGIVSHAVRGRTIKDKKCAGRDRAPVVPGLSNRVYTVASMVTGRVLGELKVSFSIVNRSLEPSGKREKEMRKRVMVSIPLQPWVKFLSCHFHCLNGSSVGSMPVKAFKNDRGMGSHLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW5</accession>
    <name>F9WBW5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001635">
        <property type="protein sequence ID" value="CCD14752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53400"/>
    <dbReference type="OMA" id="FIACCMD"/>
    <dbReference type="OrthoDB" id="1063376at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="674" mass="73540" checksum="5870986EC7078D88" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ3</accession>
    <name>F9WBZ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53670"/>
    <dbReference type="OrthoDB" id="1734885at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394848" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17407" checksum="8CB6E7277055A9E9" modified="2011-10-19" version="1">MRMYVVVVILLLMKYKIKLRILTEMREHEDLGPCAPRLNGAALILTWSRWWTRRPGAQTSTDLPGTPPTGSLKIIFPGEEMKIGNEKKRFLIFFKEKEKRGKNIYHLCTCVRVSVVMSFLPLLRLWCRWCLFVAQRCGAMPCVCASGMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC93</accession>
    <name>F9WC93_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA ligase</fullName>
            <ecNumber evidence="6">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_54580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CAEQ01001686">
        <property type="protein sequence ID" value="CCD14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54580"/>
    <dbReference type="OMA" id="ASIDIGC"/>
    <dbReference type="OrthoDB" id="274264at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="9">
        <location>
            <begin position="438"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="535" mass="58781" checksum="3B50FBECD4AB0D85" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD4</accession>
    <name>F9WCD4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_54960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001702">
        <property type="protein sequence ID" value="CCD14927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54960"/>
    <dbReference type="OMA" id="DKEMETH"/>
    <dbReference type="OrthoDB" id="551907at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="PTHR12048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF" evidence="3">
        <location>
            <begin position="97"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="536" mass="59222" checksum="46F67BCE2C097A4F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG8</accession>
    <name>F9WCG8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001721">
        <property type="protein sequence ID" value="CCD14961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55290"/>
    <dbReference type="OrthoDB" id="1722972at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19700" checksum="B3D05A6FB8EC3234" modified="2011-10-19" version="1">MNCPLLALIVFSHCSYPTARSLYRICIPILITDIVCVCVFPYLLFSLFLSFVVWCLWESSEDDQWSGGRLTYPLTATATRIAAWRVVSKLFAKRIVFLLLPLIYALIRFLFSFNLPESLRYEMVSELRFHSINSYRFPYRYLKERVSFRNVSFRFIKDARFHTAVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCN6</accession>
    <name>F9WCN6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001743">
        <property type="protein sequence ID" value="CCD15031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15564" checksum="ED27C8A839DC5CD4" modified="2011-10-19" version="1">MFRPTASGWGALCSFFSFFFSFQEYPTIFVFAPIPFTMPFIMFTFSNPNSPRHRPYQHTRKRNILAIFFSFLATCRSGRGGRRVGEKQHKTGSKERSKFLTSAATCGGGQSVTHLHRVIYWGLSGHRHAGAAGMFSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCV2</accession>
    <name>F9WCV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001771">
        <property type="protein sequence ID" value="CCD15100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56620"/>
    <dbReference type="OMA" id="THEANGY"/>
    <dbReference type="OrthoDB" id="1688455at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394682" evidence="2">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="264" mass="29207" checksum="130901E8E52FC1BE" modified="2011-10-19" version="1">MEAVAGVMRCLIVLLLLMTSKSTAFPKKATKGYCVSVKKSLASVNRRISFAKSVFESSLMSTKNVRNKCYLISKNLTDQELAENEERTRAVEEYHTAILFIQPQIRGYEVEVQRLNAELQSECNFLSSLAPWKTSLRRSARRKLAWLNDAAMQALTLSQKAKQYSILASNRGCMRSAKSQSQEEKNDPVQVPPVGVEDAGSSETATPDTTKANYTDEEQVTDTASDGPYAPSLEGDRDAGSTTNKSGHRNFNKKRGRLQAQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD72</accession>
    <name>F9WD72_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001832">
        <property type="protein sequence ID" value="CCD15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57670"/>
    <dbReference type="OrthoDB" id="1690646at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25345" checksum="6BA3179DB64D0ECD" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFIFFRVIFSFPSPGALQNCFCNNYFVSFLVFRHPVRCKTVFATIISCFSVSFLVFRHLARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDK1</accession>
    <name>F9WDK1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001879">
        <property type="protein sequence ID" value="CCD15355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58820"/>
    <dbReference type="OrthoDB" id="1752237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17939" checksum="922DC46EDA2198B6" modified="2011-10-19" version="1">MKARGGHGAGFWSEVIRTQLVQSAASVSQNSAPAIPSPSLVEAQAHICLPPSPAAFGLLSTAMWRAVSLAEDAPTRTELVWRSRTSTRPPSRLSRYQRISRALKRIGDLYPGDFVKFPGFPFRLPKGRPMFFSGSQGPSLNFWPPPWGKTTLPPPWRPQRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL9</accession>
    <name>F9WDL9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001885">
        <property type="protein sequence ID" value="CCD15373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="14226" checksum="AA46A39F77A9A717" modified="2011-10-19" version="1">MYLSFDKAFTARYFIRFVLLMSLADRLENSIPFTHRPLCCSSENPSGSVIQRPSSIQIKSERPIMLRNPQGLFRHTPPFAFCGESCRNHDVSLSRQPGSGSVTYHFQAHSNVRDFYFFMTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDX1</accession>
    <name>F9WDX1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2414</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001924">
        <property type="protein sequence ID" value="CCD15476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59940"/>
    <dbReference type="OMA" id="DECHREY"/>
    <dbReference type="OrthoDB" id="551571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="184"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="644" mass="72208" checksum="B679438AE92BEEB6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE60</accession>
    <name>F9WE60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001956">
        <property type="protein sequence ID" value="CCD15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60520"/>
    <dbReference type="OrthoDB" id="1158836at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="864" mass="97870" checksum="FF6F90D5378E45E8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEJ1</accession>
    <name>F9WEJ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_07140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002020">
        <property type="protein sequence ID" value="CCD15701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07140"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389032" evidence="5">
        <location>
            <begin position="19"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="40375" checksum="CBBC83071EA412AF" modified="2011-10-19" version="1">MLLKIWMLIFVFLLGVSADINVKKEYNKEEYNRLCKVLKAAVGAWEEVRAKGNEDALKKALERTIFGTDEGRNLGELKNCVPKDYNDVVSKLQARFLWCGDWHQEGETPELKPSRWAGHSAPHDLVCLCTVGNNSWPLDETSTAITLCGEEKSALKAKKNEGWGTIIRPSGSAKEKEKIDATWDRVAKPCLEGDGRKGATLKDALNIFMEKLVPTPGNNHTNRYRLGENSSDGYPCSGNGQVCVMYYNDTKTTGHKYSMPWWTDLADALKTEEKKEEQKKYEEEKRKKNGKNQEKSKHQEQPQNNDEPLTAALKSANPDKQEGEKDNTQNISAPLATIEEASGTLLIPPCSWLLGAFLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEU3</accession>
    <name>F9WEU3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_00910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002062">
        <property type="protein sequence ID" value="CCD15809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00910"/>
    <dbReference type="OMA" id="FTETTIC"/>
    <dbReference type="OrthoDB" id="59633at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="268"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="6">
        <location>
            <begin position="329"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="409" mass="45769" checksum="2866AC733066E305" modified="2011-10-19" version="1">MSHMLPTFGTGNRSDSILDIGESYLSSPDLSLTLTQNLKSVECTRGVRSRTLNRMNSGSVSADLEDQIADSANTGECDLARMNLLAVPPGLAFASLTSLLLSNNQIVELPDLMFADGGCGSLRTLDLNSNRLKSLPVSLFKLPQLEVLLLDHNNINGLPSNMDEECGGSFLPALRCVGLEFNDLDRFPVEFFLNCPQLEEIFLGQNLRILDQPVPTEMIRQAAVLRSTTGTPQVTLKVTNKPSFVNQMVDEKWETLMPWLKVELHKIYPDKVLPFLFIGSVRTAQTQAVYRELLIEYVLTVGRCMEVLLEPDMRHHTLPVDDVPDENIRSVFDEAFEFIDKARDNGKNVLVHCFAGVSRSATIVVAYMMSRHGYSLDEALELMKNARPEAQPNEGFMNTLRQYDIELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEY3</accession>
    <name>F9WEY3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_08460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002077">
        <property type="protein sequence ID" value="CCD15849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08460"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390241" evidence="4">
        <location>
            <begin position="24"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="98"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="45771" checksum="0C891726376BCA6F" modified="2011-10-19" version="1">MACLMKVPLASIFVGVFVSVGSGQGKGAISEGDNAEQFALLCRIYNVAKNPPINHVDLTDPYKIVNEMDSINASFAEEKQFNETEHVGNGTDAQLSHTTTLEAAAAQANIMRITQKAHNVLEDIRKLNATRDIENVKAELAHVIFGDGGNETDLGHGALKGVSGRGKACGDTGLSRKGERAGKNLVVDFFCLCAQNTEKNSGIDNVCGFFVGRKSTKFDKHGWDESGLLGSSAMWASIKKGCGKLMQQHPKSTAEVHDILEDFLKHLKSGGVYRNNKKENSYRIVGMLGTSVLSEDSRGGIDPVCDGRKGGKTGSPGGMCVFYGQEAEWQNIPWMMKLKTALSMVNALNNKTATIQRDIEKLQTLLHRAEKIYETAKVISEVQNPVLPTNLQTAAKRLTAYSAARRHHPHTHFMILFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF63</accession>
    <name>F9WF63_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002108">
        <property type="protein sequence ID" value="CCD15931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09170"/>
    <dbReference type="OrthoDB" id="440188at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="15"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23236" checksum="98E178A6DD67A04B" modified="2011-10-19" version="1">MVLARHTHRRSLNSKLRTALETKTLRIEAERAEEPTRSSTFTFDHIFDQESTQPEVYEEAVANLVEVGFYGANATILMCGQTGSGKAFTVLGGVKPNPLKNNLLTHDSGMFLWVLSDLMEYEQRQLARDFHVVVGLRCIEIYYESIRNPFGGTPGSPPPSLKAVTIGDEVLLPSPIIKEVILLQSVFDEIQLAISRRKSRSTEANAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFD9</accession>
    <name>F9WFD9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002132">
        <property type="protein sequence ID" value="CCD16007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09780"/>
    <dbReference type="OrthoDB" id="1680972at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="381" mass="45730" checksum="542DD294AB569F64" modified="2011-10-19" version="1">MGRPHSQVGPPLDPWWERRAGVHITLSKNGNSPLGGLLNERGRGLSEIIPPKIFLLLFYFFFSKTLSLRESRDFTKFPFLPNFPFFCQISPFYQIPFFTKFPLFAKFPFLRHSIFSRYSIFFTKFHFLPNFPFFPNSIFYKFPFLPNSIFLQIPLFAKFPFSRNFPFLPNFPFCQIPFFCKIPFFAKFHFLQIPPFYKFPFLPNSPFHEIPFFTKFPFSQNSLFFQILFFAKFSFLPNSIFLPNSPFYQISPFLPNSHFSRISLFYEIHIFAKFPFFAKFPFFTKFPFSLNFFFCQIPFFAKFPFFAKFPFLPNFPFSANSIFLQIPFFAKFHFFSKFPFLPNSLFLRNFLFLPNSFFDKFPFFTKCPLFTIFPFLSNSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP4</accession>
    <name>F9WFP4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002174">
        <property type="protein sequence ID" value="CCD16121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01350"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394999" evidence="5">
        <location>
            <begin position="17"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="82"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="394" mass="43101" checksum="86BA41A387D69BF9" modified="2011-10-19" version="1">MMKLFMVCLVVMGSWVREWGVMANADISVVQGDNSEYFKLLCRIYNVAHYPPIKPVDTKEYQKIVDDIDALRVAANGKEGVNTQSEEARSAQTQLTSITREAHKLLDAIKKVNPEGEEGKARNTFNQVIFGKNGKEEDLSHEALEVVDSRMAACGGKHQVATSAGKNLVVDFFCLCAQHDKVNEGVDNVCGVSVGSGDGAGWGQKLVSPDTMWKEIKNGCGKFAQQGVTSTQTGYSLYHEFLAQVTAGGNVKVNKSGIFPKHGMLGTAVSKKGNTDFKCNGQSSTNRLSGSGSCVIYGDQHQEENIAWLKKFKEGLQLIDEFNTKTAPWQSKLTTLQEQAKALYGKTRATSSLENEDTDDSPLAQHPNSDENENADSTTRSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFS0</accession>
    <name>F9WFS0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_10990</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002183">
        <property type="protein sequence ID" value="CCD16148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10990"/>
    <dbReference type="OrthoDB" id="1664783at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390313" evidence="10">
        <location>
            <begin position="26"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD16148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="414" mass="45855" checksum="302431115F4ECDB0" modified="2011-10-19" version="1">MEMCSKLWFLGVILILWLETNLCNARRAIPTKAGSAICTLSKKLKDVTPWATQQLDEEVTKITNLELKLLEWQSKFLQSKSKGRGYETCRVTGPLFRQMRKEVDKAREEVEKLEREATKAYTFAANSAGRLDEFITVFANAKNEGGNGYCLGDTTPATIEELNSCFSGKDFREESLVDISEKASEQEPNIGGAIEGIKYSALSSTFSDGSNNANCSLIKGSKNGVLENVDLEKSLWWGGGILTISKGFEGIINESSFGPGEISSAQIQGGSSKAYWTADPAKQIVHLKDSLEAIKAFKDAKENIQTKIEGIEQQIQFCLGEQEHNKHSTEPVPTEQNATQPNESITEQSYTEKTTSEQNTTETPITCFENAAQIVAQLKEKRALLTRYRKVKGWIPPNSAFIPTPRLGLLLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG30</accession>
    <name>F9WG30_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_12080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002224">
        <property type="protein sequence ID" value="CCD16260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12080"/>
    <dbReference type="OMA" id="IYYDPML"/>
    <dbReference type="OrthoDB" id="254436at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="11"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="130"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="601"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="679" mass="73993" checksum="EB8D91E381C00242" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG41</accession>
    <name>F9WG41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_12210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002228">
        <property type="protein sequence ID" value="CCD16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12210"/>
    <dbReference type="OrthoDB" id="1664906at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390325" evidence="5">
        <location>
            <begin position="22"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="94"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="439" mass="48478" checksum="9EEB060CFDED020E" modified="2011-10-19" version="1">MACFVNVLAVLLVVFGSTVSCQKELEIGRDDNIEPFSLLCRIYNVAKNPPINYVDLLEADKIVEEIDALNASLVEPKSVNETEPMENSVGAQLRHTTTREAALLQISLNQITQRAHKILEDIRKINVTKEIEKAKAEFNKVIFGEDGNESNLCHATVKGMDNRSDVCGKPGQGSRGNGAGKNLVVDFFCLCAQRTESSEGAKQACGFHVGRIDKHYGWGEQGPWGSSTMWASIKGGCGKHMQRHPKSTAEARHILDQFLKHLRTGGVYRQIKCEKDRNNCKDAIVEGSHRKVGMLGTGVTVSEGSAINCDGKEGGKEGKRNGNVNPGGVCVYYGSESNSWEENIEWLKQFKTALTSVDTANNQTATIQRSIQKLQMLQQRVEEISETAKVISEIKYPIRLASLFQNASGNLTAHNATRIRSYSYNPNLYFIPLCVLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH7</accession>
    <name>F9WGH7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_13370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002273">
        <property type="protein sequence ID" value="CCD16413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13370"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="589058at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="41"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="157"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="260"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="412" mass="44656" checksum="DB0F000F87AA7B3E" modified="2011-10-19" version="1">MRVCRHVVPRCRSCAASPILHAVQYFSPSTVASLDHLLNPTPEHRMLRDTVRRFATDRLEPQAMQSDSDMRFNVELLQELGELGVLGVTVPEEAGGAGMDATAAVIVHHELSRVDPGFCLAYLAHSMLFVNNFYHASSAAQRERWLPKVLSGEHVGAMGMSEPGAGTDVLGMTTTAKRLDGGRYLLSGGKAWVTNGTAADVVLVYAKVEGRISAFVVERGTPGFTVGPKIDKCGMRGSHMCQLFFDGVELGGENLLGGEGEGVVAMMRNLEIERLTLAAMAVGIADRCVELMTRYASERVAFGQPIWNYGQIQRYMAETYAETEAAKALTYAVSGSVCSTRCNRLGSDAAKLFSAPVAKRAADNAMQVMGAMGYARQMPVERLWRDAKLLEIGGGTLEAHHKNIAKDLIRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS0</accession>
    <name>F9WGS0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002309">
        <property type="protein sequence ID" value="CCD16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13612" checksum="8CD17C928890FE1F" modified="2011-10-19" version="1">MCSGRNNNAMFGNNPVRGGGNWQSAALTRVTWDTPAIRNPDGVKQAPQGLTKIKRGEVSLLQSKKKGNQRKQGAQQRSAGPRSYMNFTFIAQIKRSTTPYTTELPYRCCPGVATPALTDICFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW7</accession>
    <name>F9WGW7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_14690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002339">
        <property type="protein sequence ID" value="CCD16555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14690"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390321" evidence="6">
        <location>
            <begin position="26"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="95"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="350"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="424" mass="46958" checksum="D4F83D8309781C97" modified="2011-10-19" version="1">MPCLMNVIAVAVIICRFAKELSVQAQVNVQDIDNAEQFALLCRIYNVAKNPPIHHVDLQDPNKILEDIDSINASLAEEKQFNETEQAENSSYAQAKLNTTREAFVAQALLNQITQKAHTILEEIKRVNATRDIETVKAEFAQVIFGEGGSESNLCQATVNDMDNRSKACGKPGNEEKGESAGKNLVVDFFCLCSRRTDADGVDQVCAVHVGGKGGHHGWSEKGPWGSSSMWATIKKGCGKLIHHHPKSIEEVQEVINDFLKHLEAGGLYRWGETVRNTFKGSNRKPGMLGTGARTESDERGKGILCDGKRGYTDKRTGQPPGGVCVYYGQESDWKNITWLKQLKTALDSLATLNNQTATIQRDIEKLQRLLHRAEKIYETAKVISDIQNPAVPTNLQTAVKRLTAYNAARSNQLRPFILLFVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY1</accession>
    <name>F9WGY1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002348">
        <property type="protein sequence ID" value="CCD16569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14830"/>
    <dbReference type="OrthoDB" id="1067287at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="255" mass="29216" checksum="7C0F42DB8456EDE6" modified="2011-10-19" version="1">MWRTVTLAVRRKWGQRAWSPTATTSGAAPANGISAQEALQIAYRPMPPSETVEYEEDFGHNLMIHREYISKRCRDRVSFEISALSYSETELHRGKQHLAGIMNRERRGVSVGASGAPDDQVSMETDVDPNTREVLSARYLFNEKRLQFCDRFQTFFQSRLEGETGDPARNGDTQYLFSLMEACAVIYGCETDAARETYYRMFLQLDLDTLEEEEEALRNRIAEAKLVQQILQNKERGCRRTLNDRIQPSTAAWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC4</accession>
    <name>F9WHC4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16220"/>
    <dbReference type="OrthoDB" id="1696580at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25356" checksum="07858B45081DA04F" modified="2011-10-19" version="1">MQQNSSTIRQTCPHCFLLYHHSFLSPILAFSIRIPMSWYTITSTRTIPWSMEKDVVDVLLDGVTSADSINLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEVNVCDAVWHYLPYLLWKFRQSATPLVKHFGPTQTWKKWHWDSWKIYYDNDDIPLEAIDEEIWRRCRRPPPPPYQPCQEVVLVEATPAFIQVPYSTVGYLVPIPITPRPWPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR9</accession>
    <name>F9WHR9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_17480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002480">
        <property type="protein sequence ID" value="CCD16863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="14386" checksum="67DF9E1D156AFC78" modified="2011-10-19" version="1">MQDLVEQSLEEKASEIEGEYRKHKRRRRKIKEKKDRNSGDERQRPTCDKGNEQKDYYNNKGLRKEKREFNKHLLFPHLYPLFKILFPIMVAAFFFLITVIIKQEKEKNSYGVPHASKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC3</accession>
    <name>F9WIC3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 766</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002566">
        <property type="protein sequence ID" value="CCD17070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19230"/>
    <dbReference type="OrthoDB" id="111565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="531" mass="58950" checksum="F7F7D76E98ED57CE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIJ0</accession>
    <name>F9WIJ0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">TCIL3000_0_19850</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">IL3000</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01002603">
        <property type="protein sequence ID" value="CCD17138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19850"/>
    <dbReference type="OMA" id="LIQCAMP"/>
    <dbReference type="OrthoDB" id="156081at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0092">Biotin</keyword>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="15">
        <location>
            <begin position="29"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="182"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="16">
        <location>
            <begin position="1407"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="17">
        <location>
            <begin position="1768"/>
            <end position="2054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCD17138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2179" mass="241826" checksum="67E4005D515F9BA1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU5</accession>
    <name>F9WIU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002643">
        <property type="protein sequence ID" value="CCD17243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16299" checksum="785CC0E21C7F3E45" modified="2011-10-19" version="1">MSCLSLDALERFGLSSVSLCINPFLFFLAGVRGTAIAFNSRGYCRFAFVQEVNPNNDRRFSLNRWLSHKKYVRNLLEPPVYFFSLYECLAYFNLRFFPCMFLSVDASRYTAIMLNSSSCGISAQTNKHCVVTGRDIRWRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW4</accession>
    <name>F9WIW4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002647">
        <property type="protein sequence ID" value="CCD17263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14554" checksum="E1521002BABBF65F" modified="2011-10-19" version="1">MCAMPYGSTFPICCGSLDCLPLRLSNILGPHRLGRSGTGIHGKSTMTWTTCPWKPSTRRSGVGVVGRHHPHTKPARKSLWSKRRRLSYKCRIPPWGISFTYLLPPEHGLGYRTCPFYFHDQVFFAKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIX1</accession>
    <name>F9WIX1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002651">
        <property type="protein sequence ID" value="CCD17270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390451" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16145" checksum="482B1FFDF57A2A2F" modified="2011-10-19" version="1">MEHYRALRHALGAFLLEPFSLVLLCSPQLKILVHLVPLANGLLRSRFTCLRPPTGCLEPFSMRPPCLPGFTSTAPAPRNQNHRHCVASASLGSGSRVIWVVCRLWPRSYVLLVPSPWFSPFVLSGDCSSATDRSFAPRLLLPLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY4</accession>
    <name>F9WIY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 848</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002657">
        <property type="protein sequence ID" value="CCD17283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21140"/>
    <dbReference type="OrthoDB" id="4715at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_helix" evidence="1">
        <location>
            <begin position="163"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="48853" checksum="E83A94A30A685660" modified="2011-10-19" version="1" fragment="single">MARHAYIGKNDVHSNAKSQIQVASRYVAITGDKQRTLLQIDTLRRPFASMCSSCALLRIPVFASLTAVTTRGCFHIDQNVVHNSMKGVHILGILGERSTSICRNVFTDIKEASIFIEGHLASATIGDGNMFERNSASITVSMPEDECTEEERQWQLAMGIVTRIYGNKFVFPNKTSIVIKGSGSVSPVVGGNRFTDHPFGRVVIFCDSASGAVIKGNVFQENYIPIIITNSVGEHGSVKRVSVEGNLFTRNYIGLLVCDRAVPHITHNIFEGNYRSGIEIIGKGTSPTVQHCLFVPDKSGISSSSDLGKFSYPEKGLVYVENVPQFSVILQPENVVTQGDVDTILSVGILVQQESSGLIESCFFKGNQIGVDVVATNPVRLRDISTTALSDTACASFRRCLFFQQSIAGVWARGPDSGVQSHMKASARRPRFDASDEGVIFEHCFFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ21</accession>
    <name>F9WJ21_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_21500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002671">
        <property type="protein sequence ID" value="CCD17322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21500"/>
    <dbReference type="OrthoDB" id="1677171at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="68"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="289" mass="32241" checksum="15E7F9DBDAC61699" modified="2011-10-19" version="1" fragment="single">MEVSWCFLFKDCFSVFIVKERERRMIKFWIIVCLVIFGVFAQDSVTNHNGAQHKALCDVLTIAAHKWKTVRETLSPPLKKALGRTLFGKEEGELEELKDLPGDYDKVGEPGSSRAIWCGQPLNGDYQNNYPRWSGHSAPHDLVCLCTVGEGGFPFNKTGSGTAKEKLCGKPANALGGATDGWQSQSASWNKEKRVLEYPDPKGKEHITATWENVTRPCLEGGWKEKNFEKALETLIDNFIIPMSQGTKISIGLGEGKFPREKRVDWVPPALEMGVIYNPLFPLNPGGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ24</accession>
    <name>F9WJ24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 862</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_21530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002672">
        <property type="protein sequence ID" value="CCD17325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21530"/>
    <dbReference type="OrthoDB" id="759498at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="PTHR17605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOP1NT" evidence="3">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="19860" checksum="A99D6BC6B8A7CC50" modified="2011-10-19" version="1" fragment="single">MANKRGVSSRVGRGRVEAASRTRRGPISPPNEATPTTETDSELVAEPMDQCATSSTPDTTVDTAGPLSDSQPDNVHLRDELIWSDGDDDNDVILFPDAEELVRPPDTAASSSVIRLGLTQKLEESDSSEDEATLNRVGDIPLEWYKDEAHYGYDVEGRKLMKSERSALERLLGATDDPNAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ45</accession>
    <name>F9WJ45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 872</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_21740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002683">
        <property type="protein sequence ID" value="CCD17348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21740"/>
    <dbReference type="OMA" id="WQLARHA"/>
    <dbReference type="OrthoDB" id="357553at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390467" evidence="2">
        <location>
            <begin position="35"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="790" mass="86029" checksum="05DC4F0FB95EEF12" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ71</accession>
    <name>F9WJ71_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_21980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002691">
        <property type="protein sequence ID" value="CCD17375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21980"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390470" evidence="4">
        <location>
            <begin position="20"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="44"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="278" mass="30964" checksum="54D830631C48049F" modified="2011-10-19" version="1">MTKALFLVMVCLVFMLLHGRTTTSHNHNGEHYGTLCDILAAAVQKWKSTNNPTAKKALSQAIFGHPNGKGDPSKLDLPSTHLKPGNRKNWCGECMYNDQESYPGKSIPHDLLCMCTVGENGYPFIQYSEVRQLCGKGAKELGCDKDAGNAERCHSDDNKHGWTESNWDGQANKHLNATWHAIVKACLRGKPKSDVDKARKTLQKLDVGEYSTPSWAWGHSGCAGGNSDVCVGYGSWCLEHPKEYPQWWKTLYEALNAPDLRKQNDATPHALTTPRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB3</accession>
    <name>F9WJB3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 892</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002705">
        <property type="protein sequence ID" value="CCD17417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22380"/>
    <dbReference type="OrthoDB" id="1710752at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390427" evidence="1">
        <location>
            <begin position="23"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21253" checksum="99BF86E0A258BBEA" modified="2011-10-19" version="1">MLNIWGLSVLLCVGIALLEVQGIETRINTWELNILCQLDYLGTNPPAKPEVPQVAAEKLSNLLKRFEKCTAGESHDCPAGTIKMQHESINVVKLPQSPSQALAHKKLQRLNKRMMQLRMQFNRHAASVEESYSSAVRHLLESVYGSNVAGGVKRDKVDAVQQGEMFKPSGEDGDMERFCGTGEAAKGAGYDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJE9</accession>
    <name>F9WJE9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_22720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22720"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="45"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="30229" checksum="7F7819974E66CD71" modified="2011-10-19" version="1">MKVLSWLRVRMSNLSLVLVLGMGMILGMSVWSGYNKNAFSTLCAVLKSTERLLNTNTISEPLKSEMEYALYGRPGGVLTVENGKVSVKANRDSPINRSELCTYYNGGYGCFAESLAGTLLCTCTPGEGGKDFCGLGTLQNADPWSGGSTPLERKQDLFQSLWDQVRNKCPYGKGTKQGTHGDDVGHLEKAVQRVRDTLKQALPFFYLGGRPGRKVPCSGSDPRNVCAAYYTCGWSRQHVHIPWLDTIQQALEDLKAVSQTVSVPSTPTHGRDPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI6</accession>
    <name>F9WJI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 915</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_23090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002730">
        <property type="protein sequence ID" value="CCD17491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23090"/>
    <dbReference type="OMA" id="LVISHEY"/>
    <dbReference type="OrthoDB" id="1416961at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="684"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="703"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1170" mass="126593" checksum="2454A14261B2A5E5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK0</accession>
    <name>F9WJK0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_23220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002737">
        <property type="protein sequence ID" value="CCD17505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23220"/>
    <dbReference type="OrthoDB" id="1681777at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389227" evidence="5">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="37518" checksum="D03BAC64F7411F7E" modified="2011-10-19" version="1">MMMERVKIPMIVCLEFMVVMVVSGSVMNHNGAQHEALCNLLQAAVNALHRNKGGDALNKALKQTIFGNESGGDIDTLRSQVPTDYDESGGERGLWCGEPFDDEHQRWSRRWSGHSAPHGLVCLCTLGANGWPLSDSNTENTLCGQLKSALGGGKGKGGWSGNGNDGKEGNQQITATWTTVAKPCLDGGDKTGDLKKALEKFIGQLNHTWDSVKHNIYLIGEGNVSSDNACDGTASKGVCARYFPNLTSTKTWWSDLEKALIEEEQAERERELAEKKAQRKQKEQAARKDEPHTPSLSSAHPSTNQTEQSHKDSLHEEIRKYNMTSGTPISRPSSWLLSAAMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK6</accession>
    <name>F9WJK6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002741">
        <property type="protein sequence ID" value="CCD17511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23280"/>
    <dbReference type="OMA" id="PCGIAGP"/>
    <dbReference type="OrthoDB" id="1256202at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19262" checksum="D028B9569E10EC3E" modified="2011-10-19" version="1">MSAPSSHRKSNVMHTIVVPCGIAGPFVAVFEALLPSVFGWCRFDFPVFVEYIGAFAGLASATVYAGRVSHCSSYRDVTRSQWLELMWFRLDFMCLTSIAAFLGTGSWFVTLCLLAVGFYLAYRVMRIEKRVRALQLETQLVRGEVDVERVYVPGTAEAAQALGTAGRQGYDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJS3</accession>
    <name>F9WJS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 944</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_23930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002762">
        <property type="protein sequence ID" value="CCD17581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23930"/>
    <dbReference type="OMA" id="HAIQFFT"/>
    <dbReference type="OrthoDB" id="538388at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="577" mass="64655" checksum="AFB3D231063AFE12" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJT1</accession>
    <name>F9WJT1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002765">
        <property type="protein sequence ID" value="CCD17589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23980"/>
    <dbReference type="OrthoDB" id="1708488at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21402" checksum="9E36E4EEAF0F3969" modified="2011-10-19" version="1">MQTHIFHSPRTIPWSMERDVVEVLLDGVASPDKVNLYWFLRPVLAGLTVDLVCFTLGDFLRNPRHCIPEANVCDALWQYLPYLLWKFRLSATPLVKHFGPTETWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVLVEATPAIIQVPYSTMGYLVQIPFSPQSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJU4</accession>
    <name>F9WJU4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 952</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002772">
        <property type="protein sequence ID" value="CCD17602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24090"/>
    <dbReference type="OMA" id="TEYAYET"/>
    <dbReference type="OrthoDB" id="1270391at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="558" mass="60462" checksum="44F60720ABE82B79" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJV3</accession>
    <name>F9WJV3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002777">
        <property type="protein sequence ID" value="CCD17611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17067" checksum="852638658C3F166D" modified="2011-10-19" version="1">MGGPVEQFKFRCGYKYVFTGMFVCCVCVYSLVLVLFCLFFKCIHLNCFFFFFFSSSSPTSFTIFSFWFFLYLFCVFAFPSLFSLFACVRVRVRPSLKSSKEAKTFIFCFFCLICYFIKNEGGGAARRRGRGGGSKQLAIYHIITSCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK32</accession>
    <name>F9WK32_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 983</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002806">
        <property type="protein sequence ID" value="CCD17693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24790"/>
    <dbReference type="OMA" id="VESCYET"/>
    <dbReference type="OrthoDB" id="1682251at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="278" mass="30084" checksum="5A2A552E69AF953C" modified="2011-10-19" version="1" fragment="single">MRTNSMETPPPSCTPSSLSTMGSWVAVEASGLHASGAVAHNEQRKLLRPLQEESFLQPQPLRSSSCPVSLCYSDDFHDMDTVHSDWSELCVERSPTSSQVESCYETKTSEYERSGVPAKESGGDGVKSFFTPSVNVCSPPGYRCSNSEFRCVAQGVPLCYGLFCGTTQHPRASHCFSYKTADHFPALRQIAELSYNCCLVQQTSTVTVNEWPNSGSNSDGSLRSNLSSPTSPLPYGWDGVGWGNPVDQAVDMRNGNARRGSSETASFTDSESGFLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK47</accession>
    <name>F9WK47_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002808">
        <property type="protein sequence ID" value="CCD17708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24940"/>
    <dbReference type="OrthoDB" id="1656026at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="713" mass="81231" checksum="EB4838218EA08A35" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK61</accession>
    <name>F9WK61_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein DPCD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPCD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002814">
        <property type="protein sequence ID" value="CCD17722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25060"/>
    <dbReference type="OMA" id="IEWRIRN"/>
    <dbReference type="OrthoDB" id="1352989at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026224">
        <property type="entry name" value="DPCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31921">
        <property type="entry name" value="PTHR31921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14913">
        <property type="entry name" value="DPCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02065">
        <property type="entry name" value="PROTEINDPCD"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23151" checksum="7275F5F2C6CE5F13" modified="2011-10-19" version="1">MSATLAEPRTSVIVNGRRRITSKFTDGGEMIEEYDVITDDLLLRKYRSKTRLGGFSAWEVEVGSESMARNLEKELMVETSGSPELVRQDTTEFYVFRIRNLPYAKDLFSVTVEYPQPDGVGEIVVRTSNKKYFKRISVPDMNRRQIKLDPSHLTFDLQHNTLVIRYKKHLAVLAAESAAKKERVSLPAKRIDDADPNSGCNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3C4</accession>
    <name>F9W3C4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000392">
        <property type="protein sequence ID" value="CCD11634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02840"/>
    <dbReference type="OMA" id="SSNICHF"/>
    <dbReference type="OrthoDB" id="1497378at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="205" mass="22272" checksum="5C9DF4BAAFC8A016" modified="2011-10-19" version="1">MGLMSSSNICHFSDSAKKGSAEDNSNASGVTGWHGSACGGPPGYPGILPVQISVGDVNSLRCSWFSKHEAEIAREWQVSCREEGSGAVSRIPRTCPAVSFPENRTTGNLHREEEKHLWREGVPIGKNFFLALRAAWRGGGSSHQRPVPPPVAEEDLDESLIERAIAETVGQPLRPPVPLSFMVNNILVPQWVVDGLYDAPSVYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F6</accession>
    <name>F9W3F6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1047</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000404">
        <property type="protein sequence ID" value="CCD11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26280"/>
    <dbReference type="OMA" id="CDLLFLW"/>
    <dbReference type="OrthoDB" id="54708at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="983"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1716" mass="188230" checksum="0500978A303DCB26" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3V1</accession>
    <name>F9W3V1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1114</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000478">
        <property type="protein sequence ID" value="CCD11827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27700"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21791" checksum="821A678EE7FFF374" modified="2011-10-19" version="1">MSEEKICLRSRASWKCNLAYLRAPEKEKQLHLLPSKLRRCPYCARFGSNAHISRCGQQLVNCAFCRCELELARLAAHEEYDCEERRKRVFCPACEKIVPIQGDVFTDVCQCVDNEPWIVPTPPGQKAKGNKQKKGGAPKRGKKKNGVVESKAAPPTKRDAKGQAGPEPATQPARRGSTKPPVPGVRRPAEVKSKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z6</accession>
    <name>F9W3Z6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28160"/>
    <dbReference type="OMA" id="WIERWLD"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="44118" checksum="90C2E999D2C9BF7C" modified="2011-10-19" version="1">MDSGFSAGAYGAGEVNNTLSEDISLTCGVPQGSVLGPLLFIATVDSLSKRLNCIPGFQHGFFADDLTIVCESTDRSAIQKAIQPRLDCITRWSEEHYMEVSAEKTEYTLFGARETNLLSLKVGETMLKEVRTPKLLGFTMQPHKGLSKHVQGAKAVAEARLLQLRAVASPEWSPDRERWRAFYRALVQAKVCYGIASWWFVTSLSDRERLEKVQAQAAHIVSGIPKASNRNDALCEARLKPMNEVAHRRALEYYLRLKAKESTQEKLAKSIFPPEHPIFVRRSGNNLSQDFSDVWVVRHFPFMRGRQNDTTQHVMMRSIVVGLSPPCHMDPSNDPHRHHEQAPILLPTKFIFLTLFLRKRCGNVYGVVKKWGAHPQNKGPPWCALEGKRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W427</accession>
    <name>F9W427_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000507">
        <property type="protein sequence ID" value="CCD11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28460"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="601" mass="67644" checksum="2ED82FBAA70E56B4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W480</accession>
    <name>F9W480_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000526">
        <property type="protein sequence ID" value="CCD11968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12884" checksum="07DEBF1C1DB7D6B9" modified="2011-10-19" version="1">MLWLVVPLKNKTMFSDILITDLGCDCVVWDYSDPIGVPQKSKNLLRIYWTIIFPQVDTYSMPFRSTKNSAFVCVLYLFSHIVYTKFNQLIMRFIIVEYVGGFLSARRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H5</accession>
    <name>F9W4H5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_29860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000555">
        <property type="protein sequence ID" value="CCD12067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29860"/>
    <dbReference type="OMA" id="TWGKLAC"/>
    <dbReference type="OrthoDB" id="1151808at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="PTHR10317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="215"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="407" mass="45944" checksum="614FD17F335C69FB" modified="2011-10-19" version="1">MMDMLRRVLPYLDKHLVLCLLYFCDDQGLDVGDAIRSVQAATALTPEGEVSSEQERKIRETAQRARPALDEFFEQNEVENSTYQFKLTGSEIDVLRSNRELSRDVLEGKGITRNVMVAVMELAYLCYDAARYTDASELLSLCQCVTGYELDEDRLLWGKLVSDTCTCNWPSAIAVAEKLRKQQTAGVLEEDVFRVANPTTTTDRVWLLHAVLFPFFKGGSQYSAHLLNIVFDFKTENIYQCVVESVCPHYLRYICAAAILNKQRRSALRSAAAMVANIYEYSDPLTKLVDTIVNRQSFEEALALLPEVSSMARGDYFLSLHAEGLVENSKRLISARYVVTHSVVSIPYMAEKLGMSAADAEVWLANLISETKQRAKIDSVAEQMFVSSQVRSVHQTVLEKLEVIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K0</accession>
    <name>F9W4K0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_30090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000566">
        <property type="protein sequence ID" value="CCD12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30090"/>
    <dbReference type="OMA" id="MDEYVIM"/>
    <dbReference type="OrthoDB" id="809861at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="6">
        <location>
            <begin position="52"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="246" mass="27982" checksum="3CB3767447DA7EF0" modified="2011-10-19" version="1" fragment="single">MLRFARNFYSVGNFKSLLIVGRCFPTMSKCDDSQRGQESDRLTLTDAEEGNVVTRFPPEASGFLHIGHAKAALINSMLAIKYKGKLIMRFDDTNPSKEKDHFEEAILDDLATLGVSWDIGPTYSSDYMELLYGKADELINKGLAYCDKTPREEMQKCRFDGTPTKYRDLSTEETQRLWKEMQEGSPEGQETCLRAKISVDNENKAMRDPVIYRVNLTPHARHGTKYKAYPTYDFCCPIIDSVEGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4M1</accession>
    <name>F9W4M1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000579">
        <property type="protein sequence ID" value="CCD12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="108" mass="12240" checksum="375D5F69EF2FC0FF" modified="2011-10-19" version="1">MNMRCYHSRQTIALKCDDLTKWRRKHHEALRWGGSLEFVQRHSAKGNVLETERFQNYVTGTCLPHLFFICDHLIGVMGGQGTTWKGLVACIAFHTSRRAASATLTGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P6</accession>
    <name>F9W4P6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000587">
        <property type="protein sequence ID" value="CCD12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30530"/>
    <dbReference type="OMA" id="QYREMIS"/>
    <dbReference type="OrthoDB" id="1612139at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1560"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1282"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1392"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1418"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1615"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1629" mass="190258" checksum="538428274F6B2E15" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W569</accession>
    <name>F9W569_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000666">
        <property type="protein sequence ID" value="CCD12317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32100"/>
    <dbReference type="OMA" id="LYTWWHS"/>
    <dbReference type="OrthoDB" id="1036986at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="283" mass="32893" checksum="C8061830445E3628" modified="2011-10-19" version="1">MRRTVPALGSRAKGYCNRVMVYAHRRRRAWYLPPKLAHARSPLANKSPEEYGNTWDPRSGVEWYHRLRHRGAYRHWPWARWTDDPVRHHREAAGRRTFSMLEAGGNEGVPLWNYYAEVGQEYGIPSHFPLHYVATFIHQYTSKVWSEEEIERQLKLIEERTGLRTIQQVSDALPQLLKWGDEEMGSVSHGLLQHVAMLAGDIVLHNRKKAFRKEAHERGILRTIAMERYYALPHLRSGPAMPTTLEQPSGEFPRGKFTTMVGGTHIHPLHKPDGFYKDNMYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W574</accession>
    <name>F9W574_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000668">
        <property type="protein sequence ID" value="CCD12322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16348" checksum="30F1B1BEE40ACD83" modified="2011-10-19" version="1">MVARSSATVESKPMPAKPRGWILSPPTLLQWMVSTSRMLVQRGASYCSTKTFRWLLQCYIPCVHSTPRMVTSTALPWDSRYSGHTTAHEWQQHLPHHTGVVKRPVTNKTIETRQLTNNTKDRWQNASHQIEKLALHIKTTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D9</accession>
    <name>F9W5D9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000704">
        <property type="protein sequence ID" value="CCD12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32730"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17266" checksum="1E32A466772A6AA5" modified="2011-10-19" version="1">MMVVRVGSSGGSEENNHNGAAHQALCDVLKGAVGMWGKNGEHLSEPLRGALAHTIFGKDGTRNLDALIGSDVPDDYKKGILGSSRVYLCGLTHKEKEYGEKLKMRFSGHSAPHDLLCVCTPGTLGWPLTVKGSETIKDKLCGQEKDAFLASGEQELDRSGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E5</accession>
    <name>F9W5E5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000706">
        <property type="protein sequence ID" value="CCD12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03380"/>
    <dbReference type="OMA" id="WKRASRC"/>
    <dbReference type="OrthoDB" id="269827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="Iml2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="PTHR31859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="DUF3808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="656" mass="73199" checksum="769015AC711DED3F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I4</accession>
    <name>F9W5I4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000716">
        <property type="protein sequence ID" value="CCD12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33170"/>
    <dbReference type="OMA" id="IFISACC"/>
    <dbReference type="OrthoDB" id="954273at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="323" mass="35847" checksum="F83FC4B1B3186039" modified="2011-10-19" version="1">MFRYVVEVRSCHWAGEAPAEQRLEVAFHRSGVSFPVTKIPAEVVLCGSQNSELIFISACCGDKVVGCSETIEIGGIDRRVGTLTMNVRRTERETCDACTVELMWRVSEGSEAPSPRVNEEISAPSGDPAALPATLQLAHTATEQQQLPILRPQEQNVRVEAAAVHSRENGAQWCVNGPRYAPSGVLNYFVTSTQSVKGPEAWRNLYTSPAPLLVAHMQQQQQHGSEDKAPMEDSTRSKCGLPAACDDKHCFALEDIRRNPTNIADFPNEHREMIYQSRINVPWRRLVPTGLTCPSVKADFVRQEDDTRKNCAPLPAAYRFSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S8</accession>
    <name>F9W5S8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_34030</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000762">
        <property type="protein sequence ID" value="CCD12531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34030"/>
    <dbReference type="OMA" id="VNIFREA"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389908" evidence="8">
        <location>
            <begin position="23"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="48869" checksum="800A796F10CA68F0" modified="2011-10-19" version="1">MKSARNLCAIALLLFLAQTAVADYSALRLEAAKGACAVSRKLKSMYKYVKIKRKEASDILQNVDNVVKLARLRVMKEHHEHLECDKMRVFVSFVNGVRTGIRQATRRLYTAGVKVVASAGLAAGRLDEFVNIFREASHFEDFFERRDVKRHVYRFCIRGDGAEYAEKRNIGDCFMNKGESETDEFLPVDGGDVVGKSDAEIEDVIKTYLRLVDGDPRDDKGENRSCMLTVVRPSEGYLGTGQTDGNIIWGDGLLGIAKQGNGSTGSTGSTRDKSYKTNIVWEGNPTETVPTLKAFLKNYNDFNRKMAQIGLLSRKLTEEWTIEYLDRNKRDFMCAVVQSGAFKKMSSEVSAALMTDDTEYDDEDAGGGSGNEVLDNFIYMNDRKQEWLAHWDKDKIERDVLTGEFGMCRSTAGMWRNHTNRSWLFHIPFLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W610</accession>
    <name>F9W610_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000808">
        <property type="protein sequence ID" value="CCD12613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="652922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="16035" checksum="95BEFF109E02EB59" modified="2011-10-19" version="1">MIVSITKSLIMLLVIQYHFNFRGGWKRLVVCSAANLMSGLLSPLLEYGAGLLLPVDSSTEMKPAPDWELLFLATLIGALLHHNITRYWWWRCPTLIATYILFLCALSSSSFHFISAFIHTYIHIYIYIYIYNDRMNSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W614</accession>
    <name>F9W614_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_34790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000811">
        <property type="protein sequence ID" value="CCD12617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1735731at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="14898" checksum="CAE5A848B0236124" modified="2011-10-19" version="1">MGCTRHSLVMYRIVMYPYTSTHLPYFIPTQLLSVVIVVVGCCCFLSCVQYPLHATSFLFFSFLLIPMHIWPHVVVPGCLVIKTSVVRIGSHALRAGCEHAGGSNGTQASESPQFGVANQRKQRGPRFQKQLLCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W628</accession>
    <name>F9W628_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_34930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000816">
        <property type="protein sequence ID" value="CCD12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1688037at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394570" evidence="4">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="89"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="260" mass="29311" checksum="596C726F336F5531" modified="2011-10-19" version="1" fragment="single">MMKGVKYVLLFFLLWAKVPVCQAADKENAGEAEIFCQIRLLAENDPEKLVFLNEEREKQIMRHIEKVGPEIRSFVGEARKCESPIIARFNGIVKEAENLMGNVRKLRRKAAEKRLSAKRHLHQVIFGDYVEGGKGELDASAETINKIFSGDKFEQSCGGKGDKSAGKSLINDFICLCVSNTGFDDVFQPSKDESICKYGVDTAVKSDFSNWTAVWNFNSHRICINTSPLTPTPQDIHNLVELFKRAVEREQENSQVKGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>F9W688</accession>
    <name>F9W688_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1435</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000835">
        <property type="protein sequence ID" value="CCD12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1691236at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="23699" checksum="F50163A20BAD0EB4" modified="2011-10-19" version="1">MQPRRQIICANAGNNATHFQCISQYPNTHAPCRRQKPQCGQQLLHAFGFHHVPRVLGCAWCRAVVGTLACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCSTVACPGAHNGSLTPPHILSPLFCLTGHCAPSPFPHXLRAVTANQKRVCGLAGPPSFDRAPLIPPKPKKRKYFSRPQPSFSIALKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H2</accession>
    <name>F9W6H2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000870">
        <property type="protein sequence ID" value="CCD12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15702" checksum="3D16615D43649F71" modified="2011-10-19" version="1">MQVSEMWEMCSSRFVLACAYGVSLLILAFFNGFGCSARIFHDVHRLRKPVVPFFVTASMCRECFFKFRWVTCTGAVPWVSIPMLSCSVYAQETWLASDTSACFQGPALSTGHRMDLGRASKRTLASPTLRASQPSRQSGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I5</accession>
    <name>F9W6I5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000879">
        <property type="protein sequence ID" value="CCD12790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36410"/>
    <dbReference type="OMA" id="PIALVEH"/>
    <dbReference type="OrthoDB" id="1304924at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="PTHR21427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="285" mass="31204" checksum="9A673F04664B7E1F" modified="2011-10-19" version="1">MPAKVGMSKEFLCAVKKALVVEGTKLVPRFGFKDNALLSMSISALSECNSFEDVKVLNRIDISTLFPRGFPVAVVEHIVEESNKTVYLGLDKSFNKSSILKAVAKNSKLYESGRYKPPSAGDVVEQAINIKFGALLPYCDHWPEAAALEYMPSNAPFAAKSLVEFVDTTCYYVERVKSLQSVIASGNILLQARVSDSFCSPHRSNSIADVHDGSDEELFWKNFAYAVPLSSGPYIGDGFLGCGWYALRAKVAAVYGVGVLSFMGEKSGNRSETKAMVRRIVDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6M5</accession>
    <name>F9W6M5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_36730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36730"/>
    <dbReference type="OrthoDB" id="1666018at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="67"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45041" checksum="6D7F13AF352DF7EC" modified="2011-10-19" version="1">MYFLFLFGIEIGRMYPRRIGTSTWVAIVLAITMVVKGVRGGVYSDEWELNGVDHHHLCEVFKATAELWEASRQSEMKLDSGLEAALRQALFSNVGKKDLASITEAVPAAYRPAKPVHRGTWCGSCKNSERYYPGRSITHDLMCLCSAGYYGNPFYGFYLFFFKETGFKLCGRERKDMIKDRHHGWYAYNGYGLTKGLDKPWRTIVWGCVNSREKTFGTGIQDLTAKVKKLSGAMKNFTAILKVVNGRYKLGGFQGHTESDGSSETNMHVLYDTCDDKKKPWWKRLNETLTSKTPEQLLVPRKTQSPSSEPSEELNDGPEEELLEGFAGVEGLEPESSTADGGSAPQVDTENATQIQGPTNSTESTVIPLNATASGNSSHPRLEYLRSGSHINQRLLFLGAIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Q6</accession>
    <name>F9W6Q6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1507</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000915">
        <property type="protein sequence ID" value="CCD12863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37040"/>
    <dbReference type="OrthoDB" id="1696822at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="24531" checksum="0B73F5802E854930" modified="2011-10-19" version="1">MNVHKVKRRFRAEKPPTQLANKRPHILQFFWRPRVATRDTETKRDAQCPNIVLRVHITQTRLGGHANRRSKARFKRHRFRTAIVNIRSEHHGSPVGGTLNIVQWRKCAIVNARRLQSKLSRTTKVCDLTHTVNAHKNVIRGYVSMDNMAFMEVLKSTKYVTGVSPNDITWQATKCTDECIERPTRNKFRDDVQATVLEASVNVTHYVLVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y4</accession>
    <name>F9W6Y4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1534</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_37620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000946">
        <property type="protein sequence ID" value="CCD12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37620"/>
    <dbReference type="OMA" id="CEAYNIV"/>
    <dbReference type="OrthoDB" id="1147978at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PTHR10048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="95"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="101"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="371" mass="42197" checksum="D5337BD4E6FBAAD5" modified="2011-10-19" version="1">MKLIEKPLRKKQLRLRLRGAEFHDPIQRHRLYLPTEPKCRIVELIPESAGAMQSAAKCPIMIQFRCVGRGPDEMKVAPGSRDDNDAQKAGTTSTKLCIFKMGDDCRQDQLALQLIALFRRIFESIDLPHFLYPYRVVATGKGCGVIECVPNAMSRDQIGKLVEGNLSEYFVQTYGHPESETFRRARECFIRSMASYAVASFVLNVKDRHNGNILIDPQGHLVHIDFGFLFDYSPGGDMNFESSPFKLTLEMAQLMGHNVHNGRRKRQQNSLASALVDRGAYSSFVNLAIRCFLAVRHYGREICVLVELMLGSGFPCFKLKKTILNLSKRLALQKSELQAADFMRKCITNSRENLRTVLYDQYQNYAEGIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W727</accession>
    <name>F9W727_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000969">
        <property type="protein sequence ID" value="CCD12986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38040"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20249" checksum="219D36E527CA243F" modified="2011-10-19" version="1">MSNSPSSPSPEGMAREETPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9W793</accession>
    <name>F9W793_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative replication Factor A 28 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_38740</name>
        <name evidence="4" type="ORF">TCIL3000_5_1640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001001">
        <property type="protein sequence ID" value="CCD13058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38740"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_1640"/>
    <dbReference type="OMA" id="MLPGGDN"/>
    <dbReference type="OrthoDB" id="924826at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="PTHR13989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPA_C" evidence="3">
        <location>
            <begin position="176"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC90461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="29042" checksum="06D04770AC59CF76" modified="2011-10-19" version="1">MSTNAGGFFGGGGGAGAGAAVGGSATANSGGTTGPNASQPQRRMHPIRPVTIKQLLGAQRVGEGVTVIDGREVTQATVVGRVIGYEDDGSSGNFAAGGALTAKHHGYRITDGTGIVVVRQWMDAGQQDEPLPQQCYVRAAGTVKMWQNAPIVTGTVRLVSDCNELNYHFLDVILTHLRLTRGERRSTGNVPAAVSNTASAVGLQNMMPGGEEKLYATDVVLNTIKQKARGDDGLSMDEITAAAQHYGFNAQDVRAAIRTLSEEGKIYQTHDFKFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7A4</accession>
    <name>F9W7A4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_03940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03940"/>
    <dbReference type="OrthoDB" id="1696753at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="34"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="33075" checksum="46041546B47ADBB5" modified="2011-10-19" version="1">MGVLAADGMNKEVFAKLCNITRGVMGLMGKDGDHKGPLQEALYGRGGREPFEGGGRFTGGSGCGFWRGYHGRSQYCSHIKGGVPRGSTNNGCFGDSLLGTLLCTCVPGQHGQDFCGLGNVTGIGVWSGGWNSGVTQNVLKKVLDEVKKKCFENNVTDVSRHVGGLQSPINKIQNQAQKKKLNNGYYLGSGTTTNRFCDGMNASEACVTYKTNSNGTQDIPWVDKILEGIKKLNEARTQQQRGTSSSGSAIDNDHHELSDIGTDNDDDGEEEEGEEESAEQTGTHNASNPSRPKRKRTKKAAAKKPRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B6</accession>
    <name>F9W7B6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04080"/>
    <dbReference type="OrthoDB" id="1710439at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21132" checksum="08D0A8275B301C1E" modified="2011-10-19" version="1">MSYYTITSTRTIPWSMEKDVVEVLLDGVASPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEANVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVLVGAAPAFIQVPYSTVGYLVPIPLSSRAWPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7H2</accession>
    <name>F9W7H2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1611</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001032">
        <property type="protein sequence ID" value="CCD13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39180"/>
    <dbReference type="OMA" id="WPHTLFS"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="34258" checksum="DC62ABA943FA90D5" modified="2011-10-19" version="1">MEGGGVKRARDEMGGEQPHLWSEKQADAPFDPQEPWEGDVVPGVEGRLVMAVLSSEKGWPHTLFSTGEAQKEKVDSLTEYNAVCDAYIRRENLRVWNIVKGRLNEHRVDLDPFIVIGTPGIGKSFATGSLLLYQMLHYKPEWLKVVAYFVKGKAYLFHREERRVVSYRKQQVAVDEIEGMIRRGVKGYIIFDMGGSDAIIDHLPRSWGIVLISSPNVSKFHDFTTQRYHTVPIYMNCYEDAEFKAALVWERHSQGKKQVEKENVDAADEREVLKERIDMVGPLPRYALADKVTYEKRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N5</accession>
    <name>F9W7N5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001059">
        <property type="protein sequence ID" value="CCD13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39760"/>
    <dbReference type="OrthoDB" id="1666339at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389910" evidence="4">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="13"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="96"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="46647" checksum="70F4098A95FCE654" modified="2011-10-19" version="1">MACLINWIAVVILVLLGFVSGQVEVAKDDNIEPFALLCRIYNVAKNPPISYVDLEEPLEIVREIDALNISLLEEKRHDEKEDVGNHSEAQVKPIVTREAALAQLSLNQITRRTHKIWEEIKKENVEEKIEKAKDEFHKVIFGENGNESDLEQSALKGVNGRADACGDPGKGSRGYSAGKNLVVDFFCLCVRRTDEGGINQVCGFYVGIKDGQLGWNESEPMGSSTMWAAIKGGCGKHIQRHPKSTAEARHILDQFLKHLKTGGVYRWGSKDKVEGSDRKAGMLGTGVGKNENNGNGPVCNGKKGKNGQPPGGICVYYGAESNSWETNIPWLKPFKTALASVDAVNNQTASIQRVIKKLQMLQHRAEEIYETAKVMSEIHSPVVLTAFQNASGNLTAYNTTRTRSYSHRPNTYFMPLLVLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S3</accession>
    <name>F9W7S3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1648</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001073">
        <property type="protein sequence ID" value="CCD13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40140"/>
    <dbReference type="OrthoDB" id="1696700at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="24521" checksum="DBD816F1BCC44772" modified="2011-10-19" version="1">MKKCKDATNNWGGHPNSLGNLAKALAAIRDELRLHRADGGFVHILGDIRETGGCSGKATRDICAAYKYEAWKRSVPWVQTLGRVVSQLYAEYEKAMGPRITVTVPQLSPQTSGTHGNPGTSLQSQESFPHQPREVLVDEQGHTIVLEDDDFPEDLPNSTEAGWEAEENETSNPVQGPIPDPTSDLDPTSPEAAEGIVAHLTGAAHEGGASITPACAWRLFTATVALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7U6</accession>
    <name>F9W7U6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001081">
        <property type="protein sequence ID" value="CCD13268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40370"/>
    <dbReference type="OMA" id="ERCTRRY"/>
    <dbReference type="OrthoDB" id="1181470at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDCD2_C" evidence="1">
        <location>
            <begin position="234"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36511" checksum="DB1BEE87921C9B47" modified="2011-10-19" version="1">MSVKGSIWLGTPLVEGSSDCDSPFTSKIGGSAMLFRETSDYSAFRCPKCKGINNVSLLAQIYAPLDVYDRIVYVFLCAYCSKGGSSYCFVLRSQNFNPSYVHTSPGSLVNGDCGGAVFAENDDWGDDNALLQDDNSSGSLSPSTNIPSKVTDCTEAGVTCDTWTPLPLVSTGTKSPAKGICYPCFVLDIFEEPPKPNVSLDPPTDQLNKAKQKYGEAAVETTVVEDEEEPICEKVLRKYVQRIGRAPSQCVRWGPGQEPLRSSCAPITVPKCPHCMSHRQFELQLTSPIIYFLTKGAEENDHSVHFGNVLVYTCSGNCNTQPYSLEYCFVEVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7U9</accession>
    <name>F9W7U9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_40400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001081">
        <property type="protein sequence ID" value="CCD13271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40400"/>
    <dbReference type="OrthoDB" id="1658230at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="242" mass="26053" checksum="CE75E331C5AA0E7D" modified="2011-10-19" version="1">MEDKGAAVDYGYSSRGGSATDQNNRESYIFSSQDSRHSPSSGSSADDNFSRNELFRVPDKWTWIFTLLSIAVVSLGGSLYRCFKGTGERVKAGLNPDDVKCCEAAGGADVAPQTPEVCTRAAPSPAPHPVKNDAPPVFGASAGGNTFSPPSVRRSFIPRLPVAKQPDMRLGGTAQVLRSPMQVERADDISCSRGPPPQERVSPPFTQCGMLRVTTPTSEEQRNPGPNPSDVLVNPFLQRWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V7</accession>
    <name>F9W7V7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001086">
        <property type="protein sequence ID" value="CCD13279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40480"/>
    <dbReference type="OMA" id="YGDWGAE"/>
    <dbReference type="OrthoDB" id="768329at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="491" mass="55899" checksum="E2CD676474326E88" modified="2011-10-19" version="1">MLRGHLRIFNALHSGKGIRWRLFSLRTTARMQSSASAASAVVGDFSHITRNTVWGLWNEGNLFSLSVPELAFFLQEHCHVSGVDPHAKKSALVRQVEEILSAEQQASITVPQEDNPHAVVVTDYDRAEDALEEADEYGDWGVEPGFEDRRELDFMELSPGRMGERYDPLSPRAFQLLHSDTTTDICLAAVDPSKLPGLSKIKNAMLAVNVSPNEANKMHFRMAFEWCLMNIWNMNMPGELNIGAGKALYYRTVAKQNRNVMPLWTVQKHLYAQHPYAWFAIANESNRRAMESLAGAFGMSLIQEPTTSYKVSIRRMTEFFDCELNSQLKCMTLNKPWDRFFVSHYLRSKMPDLRYVVRARHPIKKRIADAYLEADILRSTRDSVQSVLSPELGDVVYCCERVVRKWAMKTQTGVTLQLVETKRTPLIITKAGDEGERLEYEWIVPLPQQAERVDIAALTEELWEYGNKLATALEEGMEELMVHAMTSVSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W3</accession>
    <name>F9W7W3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1662</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001089">
        <property type="protein sequence ID" value="CCD13285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="727053at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="537" mass="56767" checksum="223FA62633066A94" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W836</accession>
    <name>F9W836_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001129">
        <property type="protein sequence ID" value="CCD13362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41190"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394602" evidence="5">
        <location>
            <begin position="22"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="16"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="443" mass="49620" checksum="5627324006869E71" modified="2011-10-19" version="1">MVKCTGFPLAAYSACVALALGALGTAGTKPDNEKEFEVLCRVLRVAEGTPAPVPDNSSIELKAVQQARLLARYTDVNEEQYDLVVRQSKQDFSKEKLSAEDEDFLKYTVGRRTAHEKIVIIVRKMERIYKRIREKIEKATKARENAVKLLAHSIYGNTVDYLPDEENITKLLSHVDKGSIFNDPEKVVTYNGPYYARGSCGAIVHEAGRTLINDFYCLCVGVDNNSAPCVGDIKGADACHYWDGIDERLNCNISRWTQLKTDGSEEDLSEGWPVLKNKCRKTSNETDLTAEAIKVALKDFRDMLGKQHNDSDSSEFPTTLTVRDFVLGKMLKISSIRRDYDEGGCVGHKNQTCVNYWSALIKGKGIEWENNLINAMNEIETVTTEVEQAENLSVVLFSLKKEAERVYGKEIIGNVSWEFDGITPALRARDLIAYTTIACFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B6</accession>
    <name>F9W8B6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1725</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001159">
        <property type="protein sequence ID" value="CCD13448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41970"/>
    <dbReference type="OrthoDB" id="1730271at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17714" checksum="F44D8EEB26C9CDAB" modified="2011-10-19" version="1">MEVKLGSCFFLNWFLIRKRKYDIKYITCFQKKGRKNELLTHLKRFSFFQLVPSDSVFLKAYYYCHYYCLKSVLLLKTLSKFQVFFETAGVRGRVILFLRAENFSSFCSFFCPHENIRKPVKGSRCLAVARKGWPASHSPSFLSFNKSIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F5</accession>
    <name>F9W8F5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1732</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001167">
        <property type="protein sequence ID" value="CCD13487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42330"/>
    <dbReference type="OrthoDB" id="1720372at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20590" checksum="6A9C4629DBF454E5" modified="2011-10-19" version="1">MYPDAHHSLIDEIVAAFLLCACKVTSSVGKRQLITTSLFSFERCPAQKKHFTITLSLVILVAGFIFRLWPLVVQRLREAVRLRVSGVAMEADSSPRREADVEPADKEGSGALQQSKNEFLSRFESSPSSEKSKLIFGEDFDLKVQFCNVFRHFLSLQRNETENDCEEMKENCDSALPNDDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F9</accession>
    <name>F9W8F9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1734</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_42370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001169">
        <property type="protein sequence ID" value="CCD13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42370"/>
    <dbReference type="OMA" id="NGTRIMA"/>
    <dbReference type="OrthoDB" id="1027397at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="ACE1_Sec16_Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024880">
        <property type="entry name" value="Sec16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="PTHR13402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="Sec16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16_C" evidence="6">
        <location>
            <begin position="797"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1085"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1087"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1238"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1273"/>
            <end position="1300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1353" mass="141790" checksum="53FA281BB4F13A5F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8J9</accession>
    <name>F9W8J9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001175">
        <property type="protein sequence ID" value="CCD13532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16852" checksum="1BBD30CE41385234" modified="2011-10-19" version="1">MKPAPQGECNKEKHTPLRMCGVAYCLKYSLSDGIPQQMFVVPQLSPSIFTLFDKGNIISKKSAYFRRFLEKSDSLSSPCSSLIMLLPSPQNFSSSTERLSSDKFPLRELACMVEYSLLNSVHHFDIDKQEGNIQWGEKCTSMRERVVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L2</accession>
    <name>F9W8L2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1745</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001181">
        <property type="protein sequence ID" value="CCD13546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42880"/>
    <dbReference type="OrthoDB" id="838642at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="34870" checksum="34296D08ED7AC7D8" modified="2011-10-19" version="1">MYDFITQSFATETVQAVEDKTVTYQLAFSSLQDLFNEQPDIAAQLLQNVSEVLRVMAIDEYRKQNSLLNVLKRAASISRVPTFLVVPKGWGFAEDVVQDIVSSIALRRITEICTGQVRFSLPQIKSFDWNALLFRNQIACTIVGSVVRNIVYHSLIRFGVMPATMLSSVVLSPFRLKSMGVTWNDLTYRVVLVETLVLALGLWTPIATHAGFLVVQRRVEALLRCRCTAMMRLLITVVVKLVFGVLSFPVTFRPDVNDTPTLVSLFGTSAFKYHQWKQVLLILLRCVVHVLLNGVRGIHKALVEKRKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R8</accession>
    <name>F9W8R8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001207">
        <property type="protein sequence ID" value="CCD13604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="15058" checksum="259A468DB22B8800" modified="2011-10-19" version="1">MGPIATHTERQYEFQHPSSLFVFFRISPIFSFLLFSFSNIKKNSLCDLSMESSPSFFFFFCSTRINYKKRIFFLMNANKLTFSDNRKKTTFGNAIKQGLVKIKGPNTATKQNKMKPKEEKQTNKQTGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W919</accession>
    <name>F9W919_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13900" checksum="7CB6273B373DE07A" modified="2011-10-19" version="1">MIMRLHVRQQLIVRVCRFVLFLFVSAPGTALISVSAIALDATIVPCERVKCNCQEKNRHVNMEGEREAVPNWEMESEVEQVLIQECKTRGKMNLFYFFVEYYGWTDREFLPPNVWRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9A7</accession>
    <name>F9W9A7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001289">
        <property type="protein sequence ID" value="CCD13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44970"/>
    <dbReference type="OMA" id="HFLKQAR"/>
    <dbReference type="OrthoDB" id="472229at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="839" mass="93093" checksum="CABC79A154A2218B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9E7</accession>
    <name>F9W9E7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1854</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001302">
        <property type="protein sequence ID" value="CCD13847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45380"/>
    <dbReference type="OMA" id="CALMAGY"/>
    <dbReference type="OrthoDB" id="745783at2759"/>
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</entry>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
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                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
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                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
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                <person name="Berriman M."/>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
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                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
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        <source>
            <strain evidence="4">IL3000</strain>
        </source>
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        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
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                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    <dbReference type="OMA" id="HTIYASH"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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            <begin position="994"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9S5</accession>
    <name>F9W9S5_TRYCI</name>
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        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1891</fullName>
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            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
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                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
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                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
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                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="558" mass="62384" checksum="311161EE978F5B82" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC9</accession>
    <name>F9WAC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1956</fullName>
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        <name evidence="7" type="ORF">TCIL3000_0_48380</name>
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    <organism evidence="7 8">
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
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    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001415">
        <property type="protein sequence ID" value="CCD14190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48380"/>
    <dbReference type="OMA" id="CHHNTSF"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="66"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="49722" checksum="00C3ACF82F5B316F" modified="2011-10-19" version="1">MSSAAPNPVPAGTEPVELTAVGCKGNDEQRHDTNPTPKPEDSKENVGCFAKAGAFVAATIPPGGIAASAFNIGSTTVGAGIFGLPAASQSSGLVMAMFYLLVITAMTVFSTYALGVAADRSKVNTYEGVARVLLGKWGAYITAAARVFMSLSGCVAYVISTGDILHAILKNSSASDFLKTTAGNRLLTFIMWLCCMLPLVIPRHIDSLRHASTVAFVLMIYMVAVVVVHSCMNGLPENIKSVSVGRNESAEVVLFNSGNTAIEGLGVFIFAYVFQVTAYEVYMDMKDRSVRKLVIATIIAMAMCLPMYALTALFGYLDFGSKATSSILLMYDPLNEPEVLIGYVGVLVMLFVSYALLGMSCRNALYSLIGWDANTVAFWKHCIAVVSLSVVMLVCGLFIPKINTVLGFAGSISGGFLAFIFPALFLMYSGGFTLQKVGPLCYTATYVLLLSGIIAAVFGTGATIYGVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH9</accession>
    <name>F9WAH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001438">
        <property type="protein sequence ID" value="CCD14242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48870"/>
    <dbReference type="OrthoDB" id="1665727at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390051" evidence="5">
        <location>
            <begin position="17"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="78"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43690" checksum="ED44867D57245F3A" modified="2011-10-19" version="1">MMKLLMVMMLVIGGWVREWRVMANAKDSVNEGDNREPYELLCRIYNVAQYPPIKPVDTKEYQKIVDDIDALSAAANGKERVNTQSEATKSAQTQLIGVTHEAHNLLDGIKKVNPEGEVEKTRNEFNQVIFGEHEKEGEPSHGALKVEPKRMAACAGTNLLKNGESAGKNLVVDFFCLCAQYDDFNEGVHKVCGVSVGNGKNSGWGGKLVSPDTMWNEVKNGCEKFANQGVTSTHAGYSLYGEFLAKVTTGGNIKAKNSEKVQKPGMLGTAVSKTGDTNFNCNGKAGTGRVNVAGVCVFYGDKHQEQNIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADTQLEEENKDDSPLAQHPNPDENENADSTTQSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN6</accession>
    <name>F9WAN6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001460">
        <property type="protein sequence ID" value="CCD14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49410"/>
    <dbReference type="OrthoDB" id="185926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="258" mass="28947" checksum="DE8CFEB941BAE4C0" modified="2011-10-19" version="1">MEWEHFDFAVQWEPEDRAVLLRTVRDLLLSQELLAQLECLIYSTGISVSDGGKWEPQLHDETVRHQFVRLLLTFAQYAFATRPFAVSKYWANERFSLYLLQRGLTNKPEMNHTEVAQRAEAVADAQVLLLNSTVIPLCRSTVRVFPALQPCLTALQTNLSMWRSCSSDRGDDLCVSDSQTPNKQDALSGDAATFDVGGFKLVSSDRVERGTVLADTEGFISTQEQIRSLCGENAALQKLIAQLFSEIDMARKRGVEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU8</accession>
    <name>F9WAU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2017</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_49890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001483">
        <property type="protein sequence ID" value="CCD14370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49890"/>
    <dbReference type="OrthoDB" id="1680087at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012067799" evidence="4">
        <location>
            <begin position="16"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="40"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="94"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="307" mass="33695" checksum="158BA82A69FACF42" modified="2011-10-19" version="1" fragment="single">MTLVLFLLFCQGLERKMMKLFMVMMLVMGSWVREWRVMANGEVSVDGNDNREPYELLCKIYNVAHNPPMKPVDTKEYQKIVDDINALSAAANGKERTNTQSEETKSAQTQLIGITNEGRKLLEQIKRVNPEGQVEKARNTFHQVIFGKNGKEGHLSHGTLEVEQNRITACGGKEKEGKSAGKNLVVDFFCLCAQHTEASDGVDRVCGVSVGSGRDSGWGGTLVSADTMWGEIKDGCKNGAPQGVTSTQDGYSLYDYFLAKVKAGGNVKVIDSETVKKHCMLGTAVSKTGDTNFNCNGKKTFHSRHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX6</accession>
    <name>F9WAX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001495">
        <property type="protein sequence ID" value="CCD14400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50170"/>
    <dbReference type="OMA" id="YATEVFQ"/>
    <dbReference type="OrthoDB" id="762348at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="528" mass="56944" checksum="5A55B3B7348B8C5F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC8</accession>
    <name>F9WBC8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_51660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001563">
        <property type="protein sequence ID" value="CCD14559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51660"/>
    <dbReference type="OrthoDB" id="1680178at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394652" evidence="5">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="302" mass="33982" checksum="7951C9C0135A555B" modified="2011-10-19" version="1">MILIKCWMIVMVGIFVAGLSNGTNHNENAHRLLCKVLREAVGAFKSERGSEALKKVLKKTIFGDENGGNLDTLKGNLPGYYNDQQGRSRANVCDQAPDGEYRTGKNLPWPGHSAPHDLVCLCTPGDKMWPFNNGIDTEKLCGQDKAALAEGKNEGWNSSRTGEEVKEQIKATWANVTKTCLESDGNGNDLNEALKDFIGKLEKKPGTKYQERYQLGEGESHDYPCGGNGKVCVMYHNSTDNIKHKHPMPWWTELQKAIKVEEEEKEKKDVKRKNSRKTRRKITKKRKNKTNPNHNMYPVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBD2</accession>
    <name>F9WBD2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2091</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001564">
        <property type="protein sequence ID" value="CCD14564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51700"/>
    <dbReference type="OrthoDB" id="1726051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16673" checksum="768F64A565C35131" modified="2011-10-19" version="1">MHRTHAHTPGTSSDAGCTHTHGRVQQQDTHCASATQHVMHLPHGEETKAGKPTHTFSFVYFQYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVSRGAHTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBL7</accession>
    <name>F9WBL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WGS project CAEQ00000000 data, annotated contig 2120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TCIL3000_0_52490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001597">
        <property type="protein sequence ID" value="CCD14650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52490"/>
    <dbReference type="OMA" id="YTAGHIM"/>
    <dbReference type="OrthoDB" id="1450538at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="PTHR46009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1" evidence="12">
        <location>
            <begin position="15"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1_C" evidence="13">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="235"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD14650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="36863" checksum="B4B967DD8D6EF818" modified="2011-10-19" version="1">MSLADEVPAEWAAAIRPFLQRADEFQPRVPAVAYFLRTHAAFLAMKLRRKDSCGTEFVMKLLNALESEKQRLQQELNGVDGRTILTRYALMLFAKADDEERSEGVTANVNLMRLFFTSSILFEATAQFTEDGTLDPIALEKRDYARYIAVRLKKALDSGVPYESPNKRESAAPTNPMAGYDAALENRGEGFTEGSQSASFSYPQQAVPQTPNSAYECGRPAAGCVSPLSYEPPKAFMDSSGGGGGAAPPSCFNQQSTPQQQPAWPSPPSAAQQSMAAFQSGASHVHSSGDGENTAPKGPSLDAIIEAQNQAKQAVSALQFYDYEVARKMLRTALDLLGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP6</accession>
    <name>F9WBP6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001605">
        <property type="protein sequence ID" value="CCD14679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52750"/>
    <dbReference type="OMA" id="VMSFLET"/>
    <dbReference type="OrthoDB" id="1355029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="211" mass="22672" checksum="120F94D58A321049" modified="2011-10-19" version="1" fragment="single">MEAAALNQDVEAPTVVSGSGGDTAVVAANANSSKRLFDLLQDDSKERVVRILTAFRNLTLLEKESLAQEMGVTLPKPRDKQAATSAMSRQLTGPALEVRRRDRNYVAMSPSVSAALRVPGSSNAANRPPEAGLCSLVSEFLGDEPGYMTVPDPVEDDGAAANFQEKDLDDGLPPLLLRSRSYQALRLVRDDSVETDAPYTKSRVLNITGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW7</accession>
    <name>F9WBW7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001635">
        <property type="protein sequence ID" value="CCD14754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53420"/>
    <dbReference type="OrthoDB" id="1741501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="16373" checksum="1175740AA4EF8CA0" modified="2011-10-19" version="1">MRHISWRVLSPKEAGGRKARAPRRVGAPSQIPPDMRSNTAHGSLEKHAHVSREIHTLPPADTHGGDLPLASFTPAVAAHNACPPAFPKTSARVSRVRSSGAAFSPNTITGGQALTSRECGRHCPEACSSGNTSPATSPSPRRSARRHGGSTHGSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW9</accession>
    <name>F9WBW9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001636">
        <property type="protein sequence ID" value="CCD14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53440"/>
    <dbReference type="OrthoDB" id="1719974at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="21292" checksum="51063BA9C2D00389" modified="2011-10-19" version="1">MQYERKMTSALCCFTCEKWGRCNNRNESKKSKQSNTTGCRFKDVNRSFCFLLFPPYFFPFALVGMLLRGAAPSASVYLHSHFYLKFVNLFKNFPLFLCNCYRSRCCLSHMVFYLLHERLTCLMIEDEQVNHGDGTFGAMKRGRSICLMFLPLQKKVHVIFYVFLTHSFYFYFCCRHCCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBX4</accession>
    <name>F9WBX4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001637">
        <property type="protein sequence ID" value="CCD14761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53490"/>
    <dbReference type="OMA" id="WLSTMNK"/>
    <dbReference type="OrthoDB" id="888304at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="PTHR10826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="SSF54529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="23976" checksum="B3F2B5A241B2C7EC" modified="2011-10-19" version="1">MRRAIVLATFGARWAAPISGLSRQPEMGALPGPIALRPVFSQMRLVSNSKLAAATLSEMEDEQQRSERPEKPEMPVSWTLDRKIGETFFTMRRTYEDEEIVLQYTGECEKNGVATHTFIAFVVCKNKGLVCNMSDEEGEIVLNNVCVRQDAKLATDSAGESQAKKDELYGGPDVDDLEDSLAEALASYSEERGVNDDLGNYKERDRFREEQVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ8</accession>
    <name>F9WBZ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001646">
        <property type="protein sequence ID" value="CCD14785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12362" checksum="3279F5AB6985BFB8" modified="2011-10-19" version="1">MPSAKLITRCRYCNFQAMRSKRLSASVYRRSFQSQSRMEPAALRQKGNKAPATAATQRLGPFSHATQQTTIEKRKERNRSAEGRDAYSNEVTAPTAVPQDKCSDTRHASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC06</accession>
    <name>F9WC06_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_53790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001650">
        <property type="protein sequence ID" value="CCD14793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53790"/>
    <dbReference type="OrthoDB" id="1659254at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="554" mass="61698" checksum="D4CBD1FF27A7D0B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC54</accession>
    <name>F9WC54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001671">
        <property type="protein sequence ID" value="CCD14846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54230"/>
    <dbReference type="OrthoDB" id="1678009at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="278" mass="31908" checksum="873FC1E495142CC0" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMLFRVILSFPSPGALQNCFSNNYFMSFLVFRHPARCKTVFATIISCSVSFLVFRHLARCKTVFATIISVPVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMSFLVFRHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISVFRVIFSFPSPGALQNCFSNNYFMLFRVIFSFPSPGALQNCFCNNYFMSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD23</accession>
    <name>F9WD23_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001809">
        <property type="protein sequence ID" value="CCD15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15838" checksum="501128AEDA095F19" modified="2011-10-19" version="1">MHGLETRKDGEVFFSAQLVGFLKELFKLESPSAPTPDKPESKPARAVNRHRSPTALDTAYPPSAATKLIGVSNARAIRKRVREADSLDKAFCFNVPLVGARSGSRLRLTSPAGLQGQRDSRESSAARAELNHNEQKRLLFLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDB7</accession>
    <name>F9WDB7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2348</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001851">
        <property type="protein sequence ID" value="CCD15270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58050"/>
    <dbReference type="OMA" id="EYLVFNR"/>
    <dbReference type="OrthoDB" id="1472201at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16045">
        <property type="entry name" value="LisH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LisH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16601" checksum="6B74D662813E3884" modified="2011-10-19" version="1">MEEEDGIPYKSFSAPASVAGTTKHGSLKDAMREVLETKGVIDHVKAELRAAIFHSLQEVSTQQGDTESVRPPVPPENLLLNELIKDYMAFNGMEHSLSVFKAESGSGKESAAPAMPRAILASQMGLSGAPGNIPLLYAMLHELRIHSDAQRSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDS2</accession>
    <name>F9WDS2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001903">
        <property type="protein sequence ID" value="CCD15426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59480"/>
    <dbReference type="OrthoDB" id="1709793at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="21022" checksum="B47A676A4264A5AB" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVEVLLDGVTSADHVNLYWFLRPVLACLPVDLVCFTLRDFVRNPRHCIPEANVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDNDDMPLEAIDEEIWSRCRRPPPPYQPCQGVVLVEAAPAFIQVPYSTVGYLVQMPLSPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDU5</accession>
    <name>F9WDU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2405</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001914">
        <property type="protein sequence ID" value="CCD15449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59690"/>
    <dbReference type="OMA" id="WHIHEEL"/>
    <dbReference type="OrthoDB" id="166083at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="679" mass="75114" checksum="4750F59AC0910583" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE76</accession>
    <name>F9WE76_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001958">
        <property type="protein sequence ID" value="CCD15582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60680"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="31339" checksum="CEDE6F606ED8F32C" modified="2011-10-19" version="1">MDVLDNRDEWRKDGTTHKLVKLVCRRVKRKLVRRNRVTSLYVRAELLEKLHAARLRKSLIYYVLRGTREMLAGLLEELGLDAFMLREAVDALVKYLKHLPHENEVKRESVLSQGDAEGRVPTIISEFASDGPKQKLKTGRLYKPLIPNFPLVDGFFVVEGKGPKTIVLLQITKAKEHHTKKTTVREFRDYMGKVFEDWERIEGSYSWEIIYVQHVDSTAIKKRQRCVSPRYAANDTDLALWDRIHQYQVTLNSDIASDFIRHRGDTHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI1</accession>
    <name>F9WEI1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002015">
        <property type="protein sequence ID" value="CCD15691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07050"/>
    <dbReference type="OrthoDB" id="1720576at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17909" checksum="0968F72428B9F8A7" modified="2011-10-19" version="1">MAHESPIAKVPRHVEHRDGSEEEPKQEKGAYQYEKCGRTPALRHGSKDKNALPRHCQGSGSPRWCTAVSRRKAPDSNKGCHYTQQARPMKRDHPAHDESLRPEPRLRAKTHKASQGMIDEGDRWRVCQKSEENKADDRPVKTQRPQGNGVSRDFVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEJ0</accession>
    <name>F9WEJ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002020">
        <property type="protein sequence ID" value="CCD15700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07130"/>
    <dbReference type="OMA" id="LKVGAYQ"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="31450" checksum="4B0AA2DAC8D8C75D" modified="2011-10-19" version="1">MPHHRHSGVNEVGRILPCTCGRATLDAPRILLLVSGDVERNPGPMIRGAQWNAGGLSQAKQIALERKLHEDMVLFCLLQETHLALAECAALKVGAYQHVGQARTPHGGGVSILVRDGVGVEVGVLEEKVPERATVTLRFSADVSLTIISAYFPRKADVSSEALDTLLGANGAMVIGADVNSHHVLWDPLRPSDDKGECIVDWCVQNDMRIANTGMATRRQPGTAALSSPDITLCRDCEISNWKSASSPDSDRYWITFDVFVGTSLDVIAPSKPVRALYSWNRHVGTILEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WES1</accession>
    <name>F9WES1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002058">
        <property type="protein sequence ID" value="CCD15787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07980"/>
    <dbReference type="OMA" id="ACCAMYL"/>
    <dbReference type="OrthoDB" id="308101at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="575" mass="63878" checksum="273B04EFF37DDB28" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF53</accession>
    <name>F9WF53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 351</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002105">
        <property type="protein sequence ID" value="CCD15921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09130"/>
    <dbReference type="OrthoDB" id="354219at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="634" mass="70920" checksum="18009ECFFDD91081" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFD5</accession>
    <name>F9WFD5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_01220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002129">
        <property type="protein sequence ID" value="CCD16003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01220"/>
    <dbReference type="OMA" id="NVREHDG"/>
    <dbReference type="OrthoDB" id="287971at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="655" mass="73485" checksum="AF6104E8A9376985" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG36</accession>
    <name>F9WG36_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 462</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002227">
        <property type="protein sequence ID" value="CCD16266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12140"/>
    <dbReference type="OrthoDB" id="1654590at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="926" mass="101521" checksum="932E3DD4F1B6357A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG50</accession>
    <name>F9WG50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 465</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002231">
        <property type="protein sequence ID" value="CCD16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1473359at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="710" mass="76879" checksum="97B8C1EAC2DB907E" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG54</accession>
    <name>F9WG54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002232">
        <property type="protein sequence ID" value="CCD16288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00020"/>
    <dbReference type="OMA" id="GNHQYKV"/>
    <dbReference type="OrthoDB" id="1586807at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20950" checksum="5C976C9C8E788A31" modified="2011-10-19" version="1">MNLVPNRVHCPDSLITRTLEPFLGGPKFAVLSCGNHQYKVAVGDVIAVQRLRAEIGSRIALKKVLMVGGSRFTAVGRPFLEGVRVTADVEEQKRMRNVVSLFATPGRRNVRWVDAPHAATIIRIREIFYSPNIVGEVDKYKGELQAVFRPEQHTNPVYPMDDGYDIFRKRDTEAVEDATTFLDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG69</accession>
    <name>F9WG69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 471</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002238">
        <property type="protein sequence ID" value="CCD16303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12430"/>
    <dbReference type="OrthoDB" id="888660at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="21811" checksum="04ABF6E862BA2B86" modified="2011-10-19" version="1">MEDAKIGFLGGIVPPGFTTMRICISLRQAMLVEAPLRFKMPPSPVPLRELLANADPMPSPERLNRYRQIMLRWYQRIEAVGENGRMQTRSRCPEPPANIVDLRVSCDIEALLSWSSVCCRWWDETSRKRSRRGHRSGRGAWAGGRDGTLARGQVSAQTQAHSERQDQTQAQSQSGLASADALCPNWVHDLLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG91</accession>
    <name>F9WG91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002247">
        <property type="protein sequence ID" value="CCD16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395016" evidence="4">
        <location>
            <begin position="22"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="90"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="426" mass="46581" checksum="18B24D0CAE891DF7" modified="2011-10-19" version="1">MAFSMIAISIITFNLLGVASGQVEVARDDNIEPFSLLCRIYNVAKNPPINYVDMEEGYNIVEEINALNRSLLEEERLHEKDDAGNSSEAQVKPTVTRDAAVAQLGLNQISQRAHTIWEKIKRMNVTKEIGNAKAEFAQVIFGENGNERNLDHTALSGVNGREDACGKPGGGTKGINAGKSLVVDFFCLCAQRPDGAGINQVCGFYVGSNRENGLLGWNDTHGPEGSLTMWSSIKGGCGKHMRQHPKSSAEAHHILDQFLKHLRTGGVYRWGQNNDKSKAVKEKEGMLGTGVGKEKGDIGNGPVCDGKKGNKGGQSPSGICVYYGAESNSWEGKIPWLKTFETALATVEEINNQTATIQRSLEKLQMLLHRAEEIYETTKVMLEIQNPEKLATLPNARGNLTAYNATRTRSYSPNSYLFPALVLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB7</accession>
    <name>F9WGB7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002255">
        <property type="protein sequence ID" value="CCD16351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12890"/>
    <dbReference type="OrthoDB" id="1713695at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20130" checksum="6C66BBE7E1A7B5A7" modified="2011-10-19" version="1">MENIILGYTKDCMAYDNSAHQARISIESRLTSSIPTNELPLQKRKVTYLVEAPHHQRFGPRRHPLNAVSKHDIGRSLLVVHPLPGCFKSPSHPIALLHSPIRAYRMKKKNIIILTTVAVVIIVYEPSLTDCGSHRSTIMLFFPLEMKQALCCCRPSAWEIHWCHSSYYIGNGSTPPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGG2</accession>
    <name>F9WGG2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002269">
        <property type="protein sequence ID" value="CCD16398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13220"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389113" evidence="1">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17416" checksum="DCD3D2FF380E3CD7" modified="2011-10-19" version="1">MELEMWRRVLLVLMVVGNGLGASGNNQDVFEKLCRIAGNVSALMGNDNVVKSPLKEALYGGNGEAHFDEDGTFRGGCGLWHHARSQYCSHMGPNHHPTNGHGCFADSLAGTFFCLCVKGNGGEKDLCRLGNNLGDGAGWTSWDSPVNSLLPTVWDAIPEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGK4</accession>
    <name>F9WGK4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002282">
        <property type="protein sequence ID" value="CCD16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15367" checksum="220BF259B35C081B" modified="2011-10-19" version="1">MDSHSRQVGAVDCGDVGSLMSWVVPEPRVEATWTNFQGHSIIRRSQGTRVASWEEETSLPLQEVYVGTLSLEWVRRQMEDEALRLFDEVWNLMINTGGTAKRDRESHLRIATGDVHVMKQAVVSSVMPLVCQQRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH09</accession>
    <name>F9WH09_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002359">
        <property type="protein sequence ID" value="CCD16598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15080"/>
    <dbReference type="OrthoDB" id="1682472at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="32644" checksum="50626A233772AAC7" modified="2011-10-19" version="1">MTLFEVISGFVKMTLSEVISGFVKITLSEVISGFMKMTLCEVISGFMKMTLCEVISGFVKITLYEVISGFVKITLYEVISGFVKITLSKVISGFVKITLSEVIPGFVKITLYEVISGFVKITLYEVISGFVKITLCEVIPGFVNITLSEVISGFVKITLSEVISGFMKMTLCEVIPGFMKMTLCEVISGYVKITLSEVISGFVKITLSEVISGFMKMTLCEVISGFVKITLSEVIPGFMKMTLCEVIPGFMKMTLSAVISGFMKMTLSAVISGFMKMTLSEVISGFMKMTLSAVISGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH76</accession>
    <name>F9WH76_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002391">
        <property type="protein sequence ID" value="CCD16665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15887" checksum="CCDEC2C0A2E4DF34" modified="2011-10-19" version="1">MEQLTPFHPHCVPVRPRCCAAHTHTRAPQLRGAPGVLKRCPKHRHLPPAGAHVCTRSQRQAQRPLREIVRGGRTPSVIHLCGWKDKCTLNCIWKCGGNDDNNNHHEKKEKQQPRKSFAVPCHIASSEEGEKNNEKVSDGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC1</accession>
    <name>F9WHC1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_16190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16190"/>
    <dbReference type="OrthoDB" id="1669815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389137" evidence="5">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38484" checksum="0064EB501AE8607F" modified="2011-10-19" version="1">MMMRIQFCIVVIIFVGIAAEKNHNEHEHARLCSVLGAAVDKWRDIRTRDPTDTLRKALGRTIFGNESGGELTDLEGTLPKEYNGVEGISGSRSSWCGGPHEETNWQHQWRWSGHSAPHDMACLCTVGEEAWPVNKSATTTDNDKLCGQGRSALGADDSKGWGYTEHEGNRHVEATWKAIVTPCLLESGKKDDLKKALEVFIDNLNHTYDKEYRDMYRLGEGKYSSTHYAACTGSSSLGVCVMYYTSFPPEPWWRQLQEAILEDEQIQKRLAEEEKKRKQQDKTEKEDSAQKAALTSGTQTNNQTEQHRNANLTEKLRKLNLTSGTPISMPSSWLLRAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI1</accession>
    <name>F9WHI1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002438">
        <property type="protein sequence ID" value="CCD16774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16750"/>
    <dbReference type="OrthoDB" id="1711448at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="19294" checksum="9F7DD60FB23AC4C3" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFVSFLVFRRPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ8</accession>
    <name>F9WHJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002447">
        <property type="protein sequence ID" value="CCD16791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16910"/>
    <dbReference type="OrthoDB" id="1530591at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="295" mass="32611" checksum="733C52C08972042F" modified="2011-10-19" version="1">MQGSFSSGTCTDDPLPVPCTQLRTNRCVPLLWLPASLCLQLSSSEEGKNSDRTGCSEGYCVNTDINNTNVRRAVQQMSGFERNVLFEVLRQPFASMQSMQNLFPASESYYCEDAVLELLVHVATDATSIVPSRWASMEAHRDIAIVMVVLNCHEHEPNSAVRAINTVFQRHFTRCACRCVVLDPLEDTVADMPKDVVLTVSTRTPLKDVVIRVLSDIATATVRHLNTRIVEIMASHAAVKAIPRTATVGSSDGFNRFMIPGNVDDSSNSNSRNSNMVQQDVSTCGMMKRKGDFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHM0</accession>
    <name>F9WHM0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002458">
        <property type="protein sequence ID" value="CCD16813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15344" checksum="80A3B081033FE1BF" modified="2011-10-19" version="1">MTSSFHMVLPRLKRVAFSSVTARSLLPNVSRVILFPVLMLVSLSTLRTTMGLSRLAHSLGASRMYNTLLLRSNISPSSVSCFAFSTASRSCRFMCGSQLTSVPTYTGPHLLFTCTVLPIRPARNAAGTFASINLLNTKTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHT2</accession>
    <name>F9WHT2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002484">
        <property type="protein sequence ID" value="CCD16877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17610"/>
    <dbReference type="OMA" id="GISERTC"/>
    <dbReference type="OrthoDB" id="34077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="PTHR16453"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1186" mass="127094" checksum="0F33036A1157B6F4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI87</accession>
    <name>F9WI87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 746</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_18910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002544">
        <property type="protein sequence ID" value="CCD17032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18910"/>
    <dbReference type="OrthoDB" id="1704871at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21108" checksum="2682B7B923C08D3D" modified="2011-10-19" version="1">MWASIKKECENLLHQHPKSTKEGYEVLSDFFTHLKSGGVYRWGSRNVEGSNRKEGMLGTSGWKNGGYGSGPVCDGKKGSNGEHGGICVYYGPETQWEEDIDWLKKLKNALETVDDINNQTATIQRDIEKLQMLQHRAEEIYETAKVISKVQNPVGLTALPNANTKRLTAYNTAWRYHLLAPWVILIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WID1</accession>
    <name>F9WID1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002569">
        <property type="protein sequence ID" value="CCD17078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19310"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390424" evidence="5">
        <location>
            <begin position="17"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="81"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="402" mass="44539" checksum="29AD484552861BB5" modified="2011-10-19" version="1">MMKLFMVVMMVMGGWVREGRVMANTEVSVDGNDNREPFELLCKIYNVAQYPPIKPVDIKEYQKMVDDINALSTAANGKEGVNTQSEETKSAQTQLTGITRDAHKLLDGIKKFNPEGEVEMAKNAFNTVIFGENXKEEDLYHGMVSGVQNRITACGSKEKEGTGAGKNLVVDFFCLCAEPSSDDEVVEKVCGVSVGRGRESGWGGTKLVSPDTMWNEVKIGCKNVAPHTVTSTQTGHSLYHEFLTKVKAGGNVKVKDSGIVHKRGMLGTAVSENRDSKYNCNGKKTFPPRPSSASGAGVCVFYGNHHREDNIAWLKKFKTGLNIIDKLNTETATWQHQLTTLLNRARELYEKVKADSQIEEENMEEPIAAQHPNPDENENTDSSTQSQRHSLLAWALLFHKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIL3</accession>
    <name>F9WIL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002616">
        <property type="protein sequence ID" value="CCD17161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20060"/>
    <dbReference type="OrthoDB" id="75794at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390436" evidence="2">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="272" mass="30143" checksum="1262E47C155FB119" modified="2011-10-19" version="1">MHWCIGLLLVLALFVVATAFHGSAWRVVRCHDVMTGTLSTFIAVFFVDLTFTIVSFPVIFILSVLLEPLLFTILAAFSITTSLPVLLEHLPTVPADGVSCLLCPLDVGGQRHCRSLDEFCVQVVPFFSRQLLSNPPPVRWSERWSHPKPITCAHEVQQLSVECQHDNSHRPLSLTGGRKDISYTVQQLLSRCIGLVFVLRQVACWKVSRCRETSSAVVRLAHLREGYGALFPPRTAFSPEEVVDQPLADLKVSKLLSRASPVKRSSPGNAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIP8</accession>
    <name>F9WIP8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_20330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002624">
        <property type="protein sequence ID" value="CCD17196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20330"/>
    <dbReference type="OMA" id="PILHSAC"/>
    <dbReference type="OrthoDB" id="671294at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017066">
        <property type="entry name" value="E3ligase_BOI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42647">
        <property type="entry name" value="PTHR42647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="SSF159042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="406" mass="44088" checksum="8D37A068C89F7215" modified="2011-10-19" version="1">MIAGEEHQLFLAAKQAQLSRNQAAQIIMADTSHSVLQGAFVRVLLELPDQTENYVVARVGAVTTGELYGGFANNANLRTDKYLLLLLPPSLATINGTQYQLNSISNSLMTEKEFETWLGMTRVNAHMALMVNATNREGGDSQMGGPNCCIPTKQELLAIGERIHTVGAQVSAAHGFSNPAGRQQRPANGQQNAYPETQLHQGDWVMPDMPMSVARRSGTNGVASRSAVPSNGYGGIIFKAPAATQPNNNNNSNGENGQDNAASVPSGTEDGVNVGASTPRPPSSKGQAHASQPTSEQNLDLPSRHQVRQDVLNKLNQHSVVFPQNIDELKLSQLRLTERDMIEYLEHVRDVLSSKQENCVVCLDHVPTVISLPCRHKVLCRLCASAVTTCPVCRSYLFELFEPKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS1</accession>
    <name>F9WIS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002630">
        <property type="protein sequence ID" value="CCD17219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20560"/>
    <dbReference type="OrthoDB" id="774122at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="859" mass="93641" checksum="A32EC8241D3AB9C1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT7</accession>
    <name>F9WIT7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_20710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002637">
        <property type="protein sequence ID" value="CCD17235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20710"/>
    <dbReference type="OMA" id="IVYSMRI"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="334" mass="38440" checksum="D0E89BFE8FF4E95F" modified="2011-10-19" version="1" fragment="single">MLVEKPAVLFRARKSRISVYMLPLMTLLALAMVSYTLYGIGNGDHTPEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDIDGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRRRIGEGGSWGPEAQVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRASLLWTTDDIVFAAGYCTTLSKDAAQAVVSYKPLAALLRKPYSIWHMMQYSSMSVMHEDVMVGRVLREKIKLDHLVIVNVKECRFHDVPNNLERRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY6</accession>
    <name>F9WIY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 849</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002658">
        <property type="protein sequence ID" value="CCD17285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21160"/>
    <dbReference type="OrthoDB" id="1719970at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19658" checksum="8934CD012BB2C69A" modified="2011-10-19" version="1">MKGSQTTLSPATGTLVLQPPTCQARKGTVLNVVVEEQKVQDREYIDVTSQSSQASRPSQVNQVGVEGGREPIYISSTESTQPDPHNHGGEPVTYIDISSEEWPGLPFPYCSRKCTEALPLLQPEPLGPLLAGIQCSIYKCICAFRLCFLELAARVDLAAWFLPTHRYTPLFPYFFLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ76</accession>
    <name>F9WJ76_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002693">
        <property type="protein sequence ID" value="CCD17380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22030"/>
    <dbReference type="OrthoDB" id="806357at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="693" mass="76201" checksum="B231EF1D33ECBE50" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJC8</accession>
    <name>F9WJC8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002710">
        <property type="protein sequence ID" value="CCD17432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22510"/>
    <dbReference type="OrthoDB" id="1722076at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17750" checksum="A9C6079416A7E1FB" modified="2011-10-19" version="1" fragment="single">MNGIESAISANDIKGQILRWGVPYQQDNERQRGSNHEVHPPTKDDDRVQRQWYQLPYELQAHLKRRVSDILAQIKCVSSASHFDRHLVEVSELLDCDAPTGFTPTMILEGVPEIINLLSDAVLKRKVEDRCEENIKTMRAFTPLCQRVSPVRTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR1</accession>
    <name>F9WJR1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002757">
        <property type="protein sequence ID" value="CCD17569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23800"/>
    <dbReference type="OrthoDB" id="620817at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21362" checksum="B9F846729D29C58D" modified="2011-10-19" version="1" fragment="single">MLVPSAALRRYRLFHPRREAIPLHMCPVKTIFPLINSNNLLAKTRNSWQDFAGRKEFDEDHPLPTVGSRLSERTTHHKWNHWDQYLNPQITQSIKDLTPTPEYVGRRSGHNMIKMGWMKIGGSWKYSRGYNDSRRGFARGQWQERKMTPRFMLAPRVSPGGPRNRYEGKLVFSPLRLSKLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX3</accession>
    <name>F9WJX3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002783">
        <property type="protein sequence ID" value="CCD17633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24390"/>
    <dbReference type="OMA" id="IWELADE"/>
    <dbReference type="OrthoDB" id="699045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="385" mass="43646" checksum="91194F2AE159073F" modified="2011-10-19" version="1">MVLRRLLWVWTPHAHQHAYRKMHTTTMQLAQLVDTVEHNRNHYFDVRLPKKSGIGDQVHYRTHRTLLVPIDFSQAFDSIDQHVLSKRLALIPGVYCKRWLRNLLCDRFARTRVGNRKSAQRPVLRGVPQGSVVRPYLFSLYVHPLLNLLNTDPEISADMYADDLSIAIKGRSRAEAVLKANSYLDKLHRWTSENGLQVNPLKCEAVWFTRSTHTEDDKDCEGRFPLLFNGHEIPISTMGSTHLPKLLGVPLDTRMNFNSAATSQCTATSTRIAQLKSVAHKKAGPLPHDMRTFVIGYGASKLLYGSETIWELADESAKNAMMRTYANLARIVSGTLSTTDPESALLGANMMLLHILALKARVALFERVRSCQKEWVRRPPPEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W381</accession>
    <name>F9W381_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000369">
        <property type="protein sequence ID" value="CCD11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25600"/>
    <dbReference type="OrthoDB" id="1687258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30806" checksum="6DFFB05A6282C148" modified="2011-10-19" version="1">MYDAVFNAEWRYVARSDEYSGKWLVVSVLGMAPGEQPHLWSGAQADVRPEHKEPWEGDVVPCVKVKLVMAFLSSLKGWPCGLFQRNEVPDVSTLTEYDVTCDAYIRKEYLRVWHIVKEGLDQWMESGRVVLPLIVIGTSGIGKSFATGSLLLYQLLHYTLERLKVVAYVVEGEAYISYREERRVVHYEEQCLTVNKINHMICEGIEGYIIFDTGDGNSGVERLPCDWDVFLISSPDRKKLKRFEALRPQKTIPVYMSCYEDAMFMAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W385</accession>
    <name>F9W385_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1017</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000371">
        <property type="protein sequence ID" value="CCD11593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25640"/>
    <dbReference type="OrthoDB" id="672752at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="42723" checksum="03E5C55612E2A732" modified="2011-10-19" version="1" fragment="single">MRCLCCLEPDISLSQSSAVFPQKVVVFVSRSLHPPHYCSTPSSVNTAPWSSPRVQHCFSGFALCGLFTLFPFFLSFPVPLFPCFYSPTLVVHGFLHSSTGVGMDRSPSLRTTTDRPDRRSSSCSSSAFGSDLDEFMSKSPSPINEKKDDTLKSWHSGTNSPSRLGTPPKRASFATPLSVSTTFHPPPHGGDPPAISSSAPRRKSPSHREEVKREEPCVIKPCKDAAAQLQKTRQMLQRLDSHNDEMEGALTGLRARVDTYRSLVKNSLSKAVNGLRGDLRVLRESAQFLLHDFGVDMEQCEKIITRRIMRDVGGSLPESVSKDIRAGKGGKVSPSRAALQQTNERFGEQPSASTGLRELELQEDLIEAEQRCCALENKLKQQRETCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3A2</accession>
    <name>F9W3A2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1025</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000379">
        <property type="protein sequence ID" value="CCD11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25810"/>
    <dbReference type="OMA" id="DIWGCKS"/>
    <dbReference type="OrthoDB" id="1282076at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="739" mass="81220" checksum="8B51BAA4CAAA457E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D0</accession>
    <name>F9W3D0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000394">
        <property type="protein sequence ID" value="CCD11641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26060"/>
    <dbReference type="OrthoDB" id="1693614at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="23846" checksum="2D8B4D8D9A19FDF6" modified="2011-10-19" version="1" fragment="single">MKRPRGASRSGREKGAAVGSRITGVLRGSLGWADGSVLRESSFRIFSLCVVDGVVEGFRFWRGPCRQWEWMAPKPFGTQPSGPQGPAGSCPARECERAFVATHRYNRPRKHSLDHCRCMEPFFQVALLNRKTEGLVSKYPVLSVQLFPSDPHRLHGFLAWFLFHKGICFGLGPIGSEKNLVFVLRECFHPTRGRHFRSVPKPQKSLPPFQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F7</accession>
    <name>F9W3F7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1047</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000404">
        <property type="protein sequence ID" value="CCD11670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26290"/>
    <dbReference type="OrthoDB" id="1036414at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17360" checksum="45D17F87AA6B2612" modified="2011-10-19" version="1" fragment="single">MGDFIVVPVEVRCRPTEVNAADLSKVITTFIRQRNCTTYPGEIIPLHGASDLITSNIELLRVCDVYCPINGVAEGAVDYSLVMYHLHGDDEFASRDGGESLSSGLAAPCDDSDGGGGAPLPLCSTLKLPHASLEGLWESLHYGESSCDSCDLKRDLLQYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3J6</accession>
    <name>F9W3J6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_26690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000420">
        <property type="protein sequence ID" value="CCD11715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26690"/>
    <dbReference type="OrthoDB" id="1662551at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388627" evidence="4">
        <location>
            <begin position="22"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="86"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="429" mass="47963" checksum="E78E0397DAF6D079" modified="2011-10-19" version="1">MACFMNVIHIIIFNLLGVVRGQVKVDNDDNIEPFSLLCRIYNVAKNPPINYVDLQEPQKIVEEIDTLNSSIWEEKRSNETEHVGNSWEAELNSAVTKETAIAHLSINQMTRRAHKILEEIRRMNLSEEIEKAKVEFHKVIYGEDGDEGSLCHATVRDMDNRSKACGVPGEDARGDHAGNNLVVDFFCLCAQRTEEDGANKVCGFYVGRISHFYGWSELGPWGSSTMWASIKGGCGKHMQEHPKSTVEARHILDQFLKHLKTGGVYRQMKSGNTGRDIVVEGSERKEGMLGTGVTVSGVSDFKCDGKEGGKKGSNGASPGGVCVYYGPESKWQNIRWLKQFQTALETVDAANNQTAAIQRSIEKLRMLQHRAEEIYETTKVILEIRNPVGLPAAFQSVGGNLTAYNATRTRSHSHSHNPYFMPLWVFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M9</accession>
    <name>F9W3M9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MRP-L46 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_26990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000439">
        <property type="protein sequence ID" value="CCD11750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26990"/>
    <dbReference type="OMA" id="RYSRHES"/>
    <dbReference type="OrthoDB" id="1527405at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="MRPL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_L46_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="PTHR13124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="MRP-L46" evidence="7">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="288" mass="33026" checksum="B035A404248C3D81" modified="2011-10-19" version="1">MRLLARLPLPRVSLGRAFHSQHRTPVLPQIPVAGIKKSHATPLVRVAYLLHRHPVVKPTPHPLETEMAYLLQREHQRYSRHETSESAVHFMAQRGQSIDVLNRTDPRQIQSNFFALELYQDAMRVVLQRYKPEKRVTPHDLWDPTAHSGNSPPVRHTLQRKLDDYLHLIVRNASSGKWTVPQTALCEHETLRMAVDRAIATDNSEGLDCYVWSNAPQATVVDPTDGARVFIYVATYLSGKPTFSEFKPPARDHAWVTRHEMRQYMDDFLCPELMEALLDIAADSTFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3T3</accession>
    <name>F9W3T3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_27500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000466">
        <property type="protein sequence ID" value="CCD11806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27500"/>
    <dbReference type="OMA" id="LMGHQDY"/>
    <dbReference type="OrthoDB" id="689831at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="289"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="40586" checksum="B34AF3B7E1AFA489" modified="2011-10-19" version="1">MLLLIPAAHQEVVTSLQFSPYYPRVFCSTSGDDTGALWDLRNSPDSCNIAKLVCHSDPVNHALFVEGRDQLLLTASDDRTVACWDVREISQPVGVIRGFGEGVNKMLRLPSGVPGSGGGGSSNAVPSLLVACACDDGQVYVHSVGTPEDSQPQNGLRSENAHGTLDSLGTLMDRFWVSTNTVNDLALTPNPNLLLTASEDNAIRLWNIAPLLNGRATGDDRLVASFEEFEDPVNHIAVRYSSPPNEVPRGIDSATPSSTCWLYAACSEFVFAVDLDPINGVFGGEARTFSGHQDYVRGLEFFSEETLLTVSDDSTAIEWSLSTVQLVRQVKLHEGLVMASAMSAAKDILVTGTDNGEIRAWSLPFSTETCCASSPCEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4E4</accession>
    <name>F9W4E4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000546">
        <property type="protein sequence ID" value="CCD12035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29550"/>
    <dbReference type="OrthoDB" id="1604721at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="34328" checksum="16F9934BFEEA6A02" modified="2011-10-19" version="1">MLSDQMASQERYRKEVQKLQVELDQERSEHVRTRCELEATRDLSNLLKEQVERLRVSLAHSGVRQTSGSPCTEAHGYPPFCDAQSNFATTEPPPQQSNLSNLPQVLLDGESEAKDVDDVASKDSFQVGNPLLSNTYPLPTGDNITTQRNFENSFVELVSPSPECSSRLELGVFGDLLPSAEIKTRVTRAGGTARDDLGDCNKGDNCDVRGCFYFQQLAPGYSTRADKGLGTNSEFMQAIGKPLWSQRQEDIEELHHNAVNKDPPSIHPFDRLLGRDASLCKELLRALLDKEKELFELRSAFGLSGKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4I8</accession>
    <name>F9W4I8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000560">
        <property type="protein sequence ID" value="CCD12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30010"/>
    <dbReference type="OrthoDB" id="1677281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394549" evidence="2">
        <location>
            <begin position="28"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="317" mass="33870" checksum="E992EECE13CE3D6D" modified="2011-10-19" version="1">MLLASTVLSDTRRGIFLLLAIVHHAGAEPVADEPADTFRDLSGEAINATCRFLQCLKEATKKSKELSQVARVNYRKVKELRLRTAEATKRIVVGFLRQSRAASGKCRTALDIGRMKIAAQAANSAEEVVTKAEVRALLAKKNAERTTAHLLRFSHFILSHFMSAPVFAEKERQGSQEKEDSDAVGECPRVSVGNISTQTLKVYVEEMAAHLTGSIGVPRLDVIDRFVSSFDHLESAVEATVQAKEVAENTASDILAVASQDSSDPTGEGKASLDPMPPEGVGPFGDASGKCVSGSTPPGGRLAHSLFELVVGCGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U0</accession>
    <name>F9W4U0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1227</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_30940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000604">
        <property type="protein sequence ID" value="CCD12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30940"/>
    <dbReference type="OMA" id="WEDRVRY"/>
    <dbReference type="OrthoDB" id="186078at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="681"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="724"/>
            <end position="731"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="939" mass="104254" checksum="0149280E1EAAB329" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Y8</accession>
    <name>F9W4Y8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000632">
        <property type="protein sequence ID" value="CCD12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31360"/>
    <dbReference type="OMA" id="GRIDSCK"/>
    <dbReference type="OrthoDB" id="1654601at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="875" mass="99397" checksum="F2A8EB67443481AF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W537</accession>
    <name>F9W537_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000653">
        <property type="protein sequence ID" value="CCD12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31810"/>
    <dbReference type="OrthoDB" id="1668823at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394557" evidence="2">
        <location>
            <begin position="30"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="43617" checksum="3031F9300C68297A" modified="2011-10-19" version="1">MLQCLSPICSTLATHLIIATFVALNLGAANDNDCGLQHKAVEVLCNLAASVRRTEEIFEKLQNEDEKKLLGELMIYKEQLKDKVWEVNEMLRSRGLYHINEEERERLEKICNEAEERGEEQYKLAKRVTTLFSNISKEIRGAALEALGEKFHIITCVNAKGLLSILDCAVNGNKPRPGGTSNLENICKNHKILSMLTSEATARRDLCQQVGNQNICLPDTAEEIKSALMDWEKMKEDGVYIKRGVACVLNESWRPILEAVVTKINNLKDMRNVLMNATSNSAGYLNIVYKIKESIKSKLAFKQIIESASKAGKKGVKLAAEAVSSEWRKSVTVMMTLISDTELNFYEGDAESRAKPMSTTALYVLIAGLALFLVLVVLLIYCCCCRRKASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W541</accession>
    <name>F9W541_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31850"/>
    <dbReference type="OrthoDB" id="1720748at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17383" checksum="7215A285D0E5AF09" modified="2011-10-19" version="1">MRELETGCTYKPLIPNFPLVDGFFVVEGVGPNTIVLLQITKAKEHHTKRTTVRKFRQCMGKAFECREKVEKACSWEIMNVQHVDSGSIKRRWKCCTSGDAAGDEHLALWENTRQYRMSLNTDIASEFISRGSGWRRDPIRRVRQSRAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W580</accession>
    <name>F9W580_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 1287</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_32210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000671">
        <property type="protein sequence ID" value="CCD12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32210"/>
    <dbReference type="OrthoDB" id="1675603at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="8">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="36633" checksum="C14EA3F2942242E6" modified="2011-10-19" version="1">MEKLLDWKLKFTQHNGAPASCSGKGTLLRVEQDVMKMADKKVKQLTKKAIRAGALSGISAGRIDEFIMVFAKAKSDSNTKHCCLGKGGAGVTFELAGCFIVTTEIHSINEAKLARIPETFTEAELNLTTEIRKVTHGTLRSAFDGAISGSTGCKLIKRQTNGILQGAILGGYLWLGGGILKIDGKFGGDLKDIQAAEIDHHGEGKAKWSQNPGEKMVHLNNARVAFDNIIETNKQITTKFEDLAEKIKKRLGSQENNEKATTSAQTYIDRTAKRAAEPHAVNAELTRHQKQSGIPNLIPQENETNAANEALKNASRVRGTSNRNNTINLAYLLVTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W589</accession>
    <name>F9W589_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1294</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000679">
        <property type="protein sequence ID" value="CCD12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32290"/>
    <dbReference type="OrthoDB" id="1691077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="26033" checksum="F6EC48BA8D0FF7A2" modified="2011-10-19" version="1">MLERLHENTVKDVWYLVGDGIITLRDWALRGASTLLAWTPRPILDEAVREARKHPRSPITSRSISVQSGNEESDKLTHKVTGTPSTQRQPGGTEDNEQEEILQKACQSWEDVRLVDFLTQEYGKTRRACDPNVTVAAFLENASHYIEKDAEREEVVEKLPEKLHQLRGCILRDVPFLRAIGITTREQWAYRRFYHDILTPITNCILLRACGSPLHGGTNKEDTQIVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B8</accession>
    <name>F9W5B8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1305</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_32520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000691">
        <property type="protein sequence ID" value="CCD12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32520"/>
    <dbReference type="OrthoDB" id="1691674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="25163" checksum="F21E6AD900B05031" modified="2011-10-19" version="1">MVCLYAPGQHGWPISGTDGKKLCGQAKDDWTKDGSPGCYTMMWGETGHQGEHLNKTWDNNIRNCFRGGHAKNLEETLDKFIDKLEKIDDNQYLGNRSEGSDCSGRAYGGVCVKYTPDCIQNSWWKHLNEAIKKDKEERGKDAEQKKSEAAGKKSIEASDGFKKVPEQPKKVTQHTVTVLQPLKNEEKYNPQIAEKLLSNITVTEEKDGSPIIKPQWLLLTALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G0</accession>
    <name>F9W5G0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32920"/>
    <dbReference type="OMA" id="LVRHTWR"/>
    <dbReference type="OrthoDB" id="1459989at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18490" checksum="1F9A8BB8998EDE3B" modified="2011-10-19" version="1">MSSGRVQKYLRERVAGHLMGVIPSRWRAVLTQLATHTQSLQKEETGPCCTTSSAEAVQRDFELVNALLEEEHEIYQEGLQFLGDGDCRRNRNEVEEVPAAALRRFLQSLLTCIAAKEVAVGHWKHCILSIPPDTLRVYCHMCIAHPHVQESDVERICLSYTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G4</accession>
    <name>F9W5G4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_32960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32960"/>
    <dbReference type="OMA" id="RKVQFPF"/>
    <dbReference type="OrthoDB" id="600543at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="PTHR43982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="107"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="468" mass="52284" checksum="568B055E109C8A72" modified="2011-10-19" version="1">MAQVKVKWGKQLLELAVDLGSSVGALKEQLLRLTSVPVERQKLMGLKAARPIDDNTTLAEAGVTAGKTLMLLGTADDAVKPVKQALDTKESTTPHVTVHQHPGIVPIGLQNIANTCYMNAAVQMLRLAPEVYELLSSHESDPLVRELMRLYKLMESQSEAISPTSLWTTLISQYRTFGELNDKGQPMQHDAQEVLSAFLQRINSSMPETHKTMFTGKLTQTMVCKEDPDAQPTLQDVPFLMLSCNINTEIQTLEAGLEAAFNETLAINSEKLSREAMHSRTSRIAMLPEYLFVHMVRFSWRTDINGKVKVLKPVTFPMTLDLNMLCVEELKKELAPERARVLKRRDAEIERRRAMRQKTQLEGETKPNERGEEDTGAAESSAGGAVGNVSGYYELCGVISHKGRSADSGHYVFWGKYAEQWMVVDDNHVACVTEEDVRRLRGSGEAHIAYVLMYRSKDPRTKRSIVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H2</accession>
    <name>F9W5H2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33040"/>
    <dbReference type="OrthoDB" id="1715555at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16556" checksum="171BB60EA8DDD9F3" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQYPNTPAPCRGQKPQCGQQLLHAFGLHHVPRVPGCAWCRAVVVTPACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I2</accession>
    <name>F9W5I2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1328</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000716">
        <property type="protein sequence ID" value="CCD12434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33150"/>
    <dbReference type="OrthoDB" id="1572438at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="CBFD_NFYB_HMF" evidence="2">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18661" checksum="A2F7185FAA402439" modified="2011-10-19" version="1">MRQIVVELLFSLPQLYIYAYYILIRFFFLFYLPMEVPVKGKRMDVANALADQTGQATAGDADPPASPLPVSVRARSLAAGQVDRIVTAALPDGMHIARDARIAMQKAATVSLLYLSCLADDERRRETRRRVTLTANDIKVALKAGGMGHLAAQLGTGQVKRGRTDTETQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J5</accession>
    <name>F9W5J5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000719">
        <property type="protein sequence ID" value="CCD12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33260"/>
    <dbReference type="OrthoDB" id="1707497at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="22277" checksum="71A875BF967918FE" modified="2011-10-19" version="1">MERNRGKETTTTTRNHQMLLESNDTHFNKQVTGITAANHHNSCVHSPPQTPLHTHIHIHTRTNERVKRYKRQNCSKKHSNATKTSGRYTSPPQGRRHQNAMLHGAIKQRKVAGRERKSLENATPRMSRALSRAKVVEEQQTLTFATTKAVEKTYNDRLNTIQYSRQGLGKDEEKVKRSEGRKMHTHPLHPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Q7</accession>
    <name>F9W5Q7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1359</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000751">
        <property type="protein sequence ID" value="CCD12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33820"/>
    <dbReference type="OrthoDB" id="104740at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="SSF52087"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="62"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="284" mass="32485" checksum="5E9B1F346DB4202A" modified="2011-10-19" version="1">MSSFLQELGPVAVSHRQEVEEVKRQLNMRREELDCWVYSFLENKKFDVEETVAKLKRRLAMEAEEMAKYEFTDYMHESLRSGIIQVIGTDKSGRTVFYVTVSRDKKEADHRDEKKRTFDLMVSYGTQLRADNKRGQMVLLVNYENASLWSNVDLPFLADLALRLSKFFPGCVSKVYVCNIGATVCTVLVPFVSQLPASLSENIKFLTSVDVSSGSLLEFIDEDVLPVALGGKNDCDNQAEWDRHGEVIETYFNQMREAVVDRGLTLKDWELECLDLESKACCKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5U5</accession>
    <name>F9W5U5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="4">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_34180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000773">
        <property type="protein sequence ID" value="CCD12548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34180"/>
    <dbReference type="OMA" id="HADPATH"/>
    <dbReference type="OrthoDB" id="392590at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="PTHR12949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="655" mass="73057" checksum="7F3E2762C7321531" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5W9</accession>
    <name>F9W5W9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_34390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000789">
        <property type="protein sequence ID" value="CCD12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34390"/>
    <dbReference type="OrthoDB" id="1680077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013220592" evidence="4">
        <location>
            <begin position="16"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="80"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="281" mass="30855" checksum="8B8C020335A2A821" modified="2011-10-19" version="1" fragment="single">MIKLFMVMMIMVVMGSWVREWRVMANGEHSVNEKDNSEYFSLLCKIYNVANHPPIKPVNTKEYQKIVEDIDALSAAANGKESVNTQTEETKSAQTQLIGITQEAHKLLDEIKKENPEGEVEKVKNTFNTVIFGEHGNAGDLYHGALRGVESNRPKACGSKEKKGDSAGKNLVVDFFCLCAQPNDVSEGVDKVCGVSVGSGDSAGWGGKLDSPGTMWNEVKKGCEKYIQQSLSSTQGGHFLYREFLDKVMAGGNVKVKNLENVPKRGMLGTAVENTVKRSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X5</accession>
    <name>F9W5X5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000794">
        <property type="protein sequence ID" value="CCD12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34450"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19745" checksum="C41EBC97F69C79D1" modified="2011-10-19" version="1">MHASQQPLQALPAPQGESSDYTHLYIRKDMMSVWHVVEEQLDRWLKPNECMTPQCYIAIGTAVIGKTRGLGPFLLYQLLHYSSEELCAIAYFSKGEVCILHRHKGDTPGMAVYYNVQDGISEIERMATQCRKRYTISDEHKEDIFPYSFPPCWDALVMSTPSPDRFEHWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Z2</accession>
    <name>F9W5Z2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1405</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_34610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000802">
        <property type="protein sequence ID" value="CCD12595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34610"/>
    <dbReference type="OrthoDB" id="1697836at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="24277" checksum="E1A1F401C6FA4CC1" modified="2011-10-19" version="1">MGLEEKGMWFWMVMVVGVGTGTAAGKMRKSHNHHELADLCEVLGAEVILYNFGVTGAGLRKALGKVIFWKHAGGNLEDLQKGFPEKYGKECARTNSLGKFLYNNPDHYPRNVHPTRPSLHVYSSRRWIPVPTSRRQDSPTLCGRSAAEWEGGPNQKDGRGCHNGNEHWRSECSYHRKRARKHLDTTWDKVVKTGPRKRPTPLQNRHKRLGWKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W647</accession>
    <name>F9W647_TRYCI</name>
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        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1422</fullName>
        </submittedName>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000821">
        <property type="protein sequence ID" value="CCD12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35110"/>
    <dbReference type="OMA" id="YTPCAIL"/>
    <dbReference type="OrthoDB" id="161359at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="977" mass="108885" checksum="BE5D9FF7C2E1D88D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W650</accession>
    <name>F9W650_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1422</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">TCIL3000_0_35140</name>
    </gene>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000821">
        <property type="protein sequence ID" value="CCD12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35140"/>
    <dbReference type="OMA" id="CGTGCIV"/>
    <dbReference type="OrthoDB" id="296827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394572" evidence="2">
        <location>
            <begin position="27"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="711" mass="76867" checksum="2C18BFC30A66BCDC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W672</accession>
    <name>F9W672_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1429</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TCIL3000_0_35360</name>
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    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000829">
        <property type="protein sequence ID" value="CCD12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35360"/>
    <dbReference type="OrthoDB" id="391248at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="28013" checksum="9751DCEC915DE3E0" modified="2011-10-19" version="1">MEGSVQDALLRSKVLEEFESIVFVLYSLLSHCSTSGTCDVDEEIPMLASELVFAALKTSPDGLSTLFALPSNDALLLLPLHTRIICSIVGLLQQDHAVLRDLARILWTDHHILQRLSRVLCELGEAEEEQELRSTIYSLVLRLCTLCNTNVSTRGDGTDDIVSAFSLDVGYLLSFAAEHLLAGCWLQLSSCRSLFIHLCMHAPFRHGMHALHGEAYRMALMLVAEDSGQAGEKSLVDQWAKERSDDTLSELRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W755</accession>
    <name>F9W755_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_38360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000988">
        <property type="protein sequence ID" value="CCD13019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38360"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389954" evidence="4">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="93"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="437" mass="48371" checksum="775E8AF46FC874E7" modified="2011-10-19" version="1">MARYMNAISLIILSFVGVVSGQEEVAVGKYDNIEPFSLLCRIYNVAKNPPINYIDLDEPFKIVEEIDALNRSLSEEEGLHEKEDAGNYSATQVKQTVTRETALAQLSLNQITRRAHKILEDIKKMNVSKEIENAKAEFNKVIFGENGNASDLEHTALNGVKGRTEACGRTGLSTKGNDAGKNLVVDFFCLCARRTDGEGVNKVCGFYLGSNSEQSQYGWDHNGPWGSSTMWASIKGGCEKHMQEHPKSTAEARHILDQFLKHLKTGGVYRQIKSDGVTRKPNVIVEGSNRMEGMLGTGITVSDGSEVTCSGEEGGKERGGSRDNLKPGGVCVYYGTSDWKSKVSWLKQFQTALTSVDFVNKQTAYTQRAIKKIQMLLQRAEEIFETTRVIKEIKYPVLHTAFQNASGNLTAHNATGTRSYNNNSHPYLIPLLVLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W763</accession>
    <name>F9W763_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38440"/>
    <dbReference type="OrthoDB" id="1706727at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="25030" checksum="5DD6B7C17574E56F" modified="2011-10-19" version="1">MKVANIVNGVALAVLFVCVMLIMIDYVYSQRRQRRLQAQRAEEHSGHRHNTAGEQSHLRLMRQAVRVLLTHKLVDEGIPLASSFGVSEVMADRELRSNRNRGRPPRLTMADGTRDTITEVVRRARAAGPLPDSPPGPALMELLEALRERQQREAATQPFSESDRTPLEELIDGLVKAEEEVQYGAGPPSDAEALYGAAAPYTPNPANECICCNLSCGDDDETVFSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7A0</accession>
    <name>F9W7A0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1590</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_38810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001007">
        <property type="protein sequence ID" value="CCD13065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38810"/>
    <dbReference type="OMA" id="AYPLERC"/>
    <dbReference type="OrthoDB" id="439340at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="123"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="343"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="547" mass="60677" checksum="605729BCD7132CC2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B2</accession>
    <name>F9W7B2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04040"/>
    <dbReference type="OrthoDB" id="1673175at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394592" evidence="5">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="56"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="37489" checksum="740B448073E49A7A" modified="2011-10-19" version="1">MTMKSWILVMMVMKVGVFADRSATKNHNEEAHRALCTVLKMAVGKWGTNGEGLSDPLKTALHQTIFGYRSEEKTVEKLRDTFPIVYKEGVGGLRGVLCGQPTHGGYQDNFPRWPGHSAPHDLVCLCTVGNEGWPLNETIPEKKKLCGKTEDELGGDTEGWDSSSKEKGEKQITATWDNITKECLQSDGKKGENLKEALETLTGKLKESNHYLLGEGTYSSRSASACTGSPSFGVCVKYYPTYEETKTWWVDLQKALIEDEKIQAQKKEENRKQQEEANQRNSPKTEALKSGNPNTNKTEQHRNETVTDKLRRFNLTSGTPIILPSPWLLRAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7G7</accession>
    <name>F9W7G7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanine nucleotide-binding protein subunit beta-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_39150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001030">
        <property type="protein sequence ID" value="CCD13133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39150"/>
    <dbReference type="OMA" id="TNPAKHT"/>
    <dbReference type="OrthoDB" id="325552at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="ANAPC4_WD40" evidence="7">
        <location>
            <begin position="4"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="326"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="42628" checksum="B00C097B02E5E57C" modified="2011-10-19" version="1">MCVRYSPDMGTIATVARTGDIVLLDGQTAEKKGVIPTGHKGSIFSLAWSPDGKLIATASADKSVKIFDVVTASAIATCTLGTRVMDMQQGVAYTTRGVVSVSFNGKLSLINQKGEVQHRFAGHQGRILLVHKESDGTMVSVGVDRALIWRAALTPESGEAREVPLSAELITAATFKGGKLYLLAGNELLRCGLDDDEPVVMLKEAANAVTLTVTEDGAVVLLHRNGFTVADSTGRVVSEERLDKFDGSSAASHGNMIVLGGDKLARGYQVTAASPPEPKVVFSGHHSGTVACVAFSNDGQLVASGDASRNIFVWSFTDGSVVYRDLVFHTLRVTSLTFAYNSNTRLFSGSMDASLILWDLEAKTRRTEDAAHRGGVSAVFGAADGTLISGGSDGCIRLWKSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7J1</accession>
    <name>F9W7J1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001042">
        <property type="protein sequence ID" value="CCD13158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14769" checksum="8C3CA428A76EAE0B" modified="2011-10-19" version="1">MGPAPFSSGLRPTQSSRVTYHVDGLLPIKDENLMVYLDCEHKMDLGSLGQSIVIVMVRRNSVFLRAFEEAGRALRAEWTVLLVTEPALHNQYESACATLVEGSFRVRQNANEQLCGTRQGLTHVQEVIVQQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N3</accession>
    <name>F9W7N3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001058">
        <property type="protein sequence ID" value="CCD13204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15035" checksum="8C103307B16DF4F9" modified="2011-10-19" version="1">MRTNPSAPLNAATAGHTNKSPNWAACLSFSSYRESSHVPTSNKPLYFGGHSKGKGKKGCRKRGRSRKKKSRLSHKVYESRIAFISKSQAETICDAVCTVVSILKDRHFRRSFFREDGILLEGEEPSAEGNFTFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P7</accession>
    <name>F9W7P7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_39890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001062">
        <property type="protein sequence ID" value="CCD13219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39890"/>
    <dbReference type="OMA" id="THERTLI"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389971" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="882"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD13219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1221" mass="134688" checksum="4814D3B499CC04C4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q2</accession>
    <name>F9W7Q2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001064">
        <property type="protein sequence ID" value="CCD13224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39940"/>
    <dbReference type="OMA" id="DRGCANA"/>
    <dbReference type="OrthoDB" id="1631161at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022250">
        <property type="entry name" value="T4bSS_IcmS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12608">
        <property type="entry name" value="T4bSS_IcmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="26400" checksum="BBB17CC9644BB6A9" modified="2011-10-19" version="1">MTLRCALLLNAIRRCGQRRMMSCGFPTLAPYGTTRGETASTLWGGGDRGCANASLLRVEDMFGECGSSGSDLCDDDSTASGYCLDDDSGDIVSAFNINNTGAVAAGTPGLGLEAVMSAAVEGAVERSSEGGSADGADDISEGAYDEGLYGEIKASSGEKLSSEEVVDDDADNGFIFNEAQDDDDEVALGFNGDGVDDEAGLLEGLPPAAYEATSPVLFFRAVSPDAVPRVATVFDNAAAEGVELETVGDAMPSPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9W809</accession>
    <name>F9W809_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ubiquitin-protein ligase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ01000000 data</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_40960</name>
        <name evidence="6" type="ORF">TCIL3000_8_5870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001117">
        <property type="protein sequence ID" value="CCD13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_5870"/>
    <dbReference type="OMA" id="HPNVDMS"/>
    <dbReference type="OrthoDB" id="1444506at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="9"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC92363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17498" checksum="42D34BE929D7BC6D" modified="2011-10-19" version="1">MAVTMKNCAASMRLQKEFMEMMSCDADGISAFPVNDNLFHWVGTMQGAADTAYEGLEYKLCIEFPPNYPFSAPYVRFMTPCFHPNVDSQGNICLDILKDKWSAVYSITKVLLSIQSLLGNPNNQSPLNSRAATMWNDQAAFRAEVVAYRETKGNASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W851</accession>
    <name>F9W851_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1707</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001138">
        <property type="protein sequence ID" value="CCD13378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41350"/>
    <dbReference type="OMA" id="EAMIRIE"/>
    <dbReference type="OrthoDB" id="781451at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="239" mass="26472" checksum="60071724B5B84ABB" modified="2011-10-19" version="1">MEDTSCHGSATAVVHSEGDTESRAKEAGSLSAPLLINNSIALQDLPAEYNVSTVVECDASGHVQPRAVALDSPNDVLHHGRYYIPRRDIKNLARKSRVTFRGNVSIREFDATSAVVPYEENRAAHIGNTDMVPGLVGCDMQSYKRKRECAVVEVGEGNDIFDGISVKNYRFVPFMGDLYNDGRQAMIQLQDVKNFCESVELDVVEFNERHTRAERMLAEAKRLLECRTSVVGNGHVNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8A8</accession>
    <name>F9W8A8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001156">
        <property type="protein sequence ID" value="CCD13440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41890"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389942" evidence="5">
        <location>
            <begin position="19"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="56"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="40841" checksum="E44C2316BF6B63BD" modified="2011-10-19" version="1">MGWRFMVTVLFSWNLLCGGILVYGNNGYNSAEYLLLCNLTRKVSSLLKSGGISVNAATNLRDAIYGVSNRALFKEGGEVHLGLGCSKLPNGRALQCSYYNSDGCFAESLIGAFFCACTPSSREGGVNTFCGVDANQYHDSWTGEWVTPGRKTNLFKDVWKYVIGDCHEKHEIMNNKALELEYLKLSVKEVRRKIEEDKRNNGFFYLGGSGNTVCNGYNVNDVCVRYNGKGTSVVKIPWIDKLEEAIKELGKTLETQEREVGVKDSRLLQPGALVPVKVHKVLEKNTGQGVQNKASIDRTKKQFKERMDETEIHGRQESAEYEHKSTEARATSNSPSITDIPHLATNNNEDGSIITRPSWLLLSISFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D5</accession>
    <name>F9W8D5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="13957" checksum="CAED9E07E6D42A0E" modified="2011-10-19" version="1">MLGATKGGLWPWGQLRGNEMAHLNHVAFLFCWIVGGCLSFNTHAIYGGQGVRAGGGGVWRCCVSGRGLTSAVVVMVIYPNCLTVRMTRWRDVKALLTCTECDGGSWPGRANGISLTTGVLPRVAGYWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8K2</accession>
    <name>F9W8K2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_42800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001175">
        <property type="protein sequence ID" value="CCD13535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42800"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390011" evidence="4">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="94"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="416" mass="45968" checksum="4E3CC5223CF88C6F" modified="2011-10-19" version="1">MSCFMIVIAVVIFRLSECVSGQEQVNVQDNDNSEQFALLCRIYNVAKNPPIDNVDLQDPMKVVKEIDALNASLMDPKGFNETQQVGNSSGVQLKPTTTREAAVAQALVRRITQKAHTILNEITKLNVSEEIEKVKAEFHKVIFGEGVNGSDLCHGALKDIELRGNSCGKPGEGEKGSHAGKNLVVDFFCLCAQRKDGEGIDNVCGVYVGASKKNGNHGWESECPSTSSTMWGSIKKGCGRLVHQNPKSNEEGREVLKDFLKNLETGGLYRWGDNRKVNGRNRREGMLGTGVGKEASGRDIVCDGKRGGRQLPGGICVYYGNNDWEENIDWLKKLSTALNAADTMNNKTATIQRDIEKLHTLLHRAEQIYDTTKVITEIQQTVVPTNPQTAAKRLTAYNAVRRHRHHTHSILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8N0</accession>
    <name>F9W8N0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1751</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001187">
        <property type="protein sequence ID" value="CCD13564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43060"/>
    <dbReference type="OrthoDB" id="1700058at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="25681" checksum="195217E1307195A0" modified="2011-10-19" version="1">MSHSSLVLPFLRTHTAPTSPNQTVRKCLKRRKGRPFQKGGVDFKSKGKDGKETTGQLKKKIVSGRGKRTKVKKKRERKRTGSQQAHACRELFLDGCSLPITLQNHTITAHKRTRCFTQHRFVVWSDTRYIAKFSAVSRLRFGSKNKPSLRKVEGSFARTRCCSLKLKRKEKSCPAAPLHSSHRLFTARNNCCTVQRENEKGPDWPVELEHKTNQKKKNGEGSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8P0</accession>
    <name>F9W8P0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1756</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001193">
        <property type="protein sequence ID" value="CCD13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43170"/>
    <dbReference type="OrthoDB" id="1732233at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16830" checksum="99E4E51EB8493B87" modified="2011-10-19" version="1">MRLFFTCTHTPFSRTQQLLLNWNINFLPFHGMFGIPVSDCACHQLGHEILGFPLRVGQPHHLLLHGDRPSNSRIVSMPLLSSLGIPRDSPIQPLSKSRTSAAVPSHYSAHYHSQALLSSPHAPQYAHRSSHHRHERARAGEKIRMWGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8S4</accession>
    <name>F9W8S4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1771</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001209">
        <property type="protein sequence ID" value="CCD13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43490"/>
    <dbReference type="OrthoDB" id="1704879at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="21986" checksum="5158422B10ECDB82" modified="2011-10-19" version="1">MRPANKTYLQVRHYTICTDASTSGGGGIVYDNTNGGLSTYGGKWQYKQSATQIAELEALALVNSWEQWKATLGLSKRCLDHSRLRSDKPTHDADAYTATAAVHIRFMVDSSVLLWALTKRQSGNHLVWKYIRPILKDISRLNTLSNTTYSAAYVHTNLNPADELSRARTLNPTKVHRSIVQNTEMGMTPEGITWLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8S5</accession>
    <name>F9W8S5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1771</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001209">
        <property type="protein sequence ID" value="CCD13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43500"/>
    <dbReference type="OrthoDB" id="1660995at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="468" mass="53324" checksum="ECE5E0BC166014FF" modified="2011-10-19" version="1">MSRNNSSNNTGPDPRDPQRMEDALVPYGRQTAPPGPTAPQNEETPDDTLRHNIPTRAAKDSTHTPRRMGEDLGPKRPYYSMGQMCRLMQAEQMEAGVSEKNLSQLCVEYPDATEMVRTSHDGLPGRFLRTARDADSMRLEMPDVPIGTTVQTPTGCCRMIIDNETRQHIATQELEAQMTNRRILHLHNNRERLRKFESVKTEIEFTQAMQIALRTFTGTLYVLEKYGPAITIEGTLKANGASWENHLQWLGRKDEDGSPMEPGQAHGRFDHYRVAFQAACYWADHHERTIYALAGPLKQDIPVFSSYDYDEMMSAFVTFTIAIIAKVYAGKRIDISAIRKNYAEGISDEIQQSIDDHINRFVNHKYKGVAYDRRPMIPRLTRAASRHTYLGTGTRHRALSTESRRGKNAKGRYKQFGRSDFKHRIRRTETPSPSRSQENTPRRRNKSGARSKTKNQGKSRVRFSGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W907</accession>
    <name>F9W907_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_44300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001250">
        <property type="protein sequence ID" value="CCD13696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44300"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="24"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="30192" checksum="D42D373760B80635" modified="2011-10-19" version="1">MDKGSIFNDPKGVVAFNGNYYAGSSCGAIIHEAGRALINDFYCLCVGIDKKNSPCHKDIKGTLEDCNKCCSDAGKRQNVGGEKCTSGNWTWLNDGDAKKDFSEGWPVLKSKCLQKTESTSLTAEAIRVALEGFRRMLGKQYNDSDSAFPTTMTVKNFVLGKMNEISSISHPQDEGGCVGEESQTCVNYWNALIKGKGIEWENDLIRAMNDMETVTTEVGQAENLAVVLFSLKKEAERVYGKEIIGNVSWEFDGITPALRARDLIAHTTIACFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W923</accession>
    <name>F9W923_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13036" checksum="D48D2404123F84D3" modified="2011-10-19" version="1">MKSARNKWAALARSHRTHAWPSLISLLPHYTTGGSIRCRGVQPKSAGITHPSLLPTLYMPFSAASSIQMLTGISHGADARPAVQHSNKLHFELLIFDDHSSQSHSTAHLQALIQGHFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9F8</accession>
    <name>F9W9F8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1855</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001303">
        <property type="protein sequence ID" value="CCD13858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45490"/>
    <dbReference type="OMA" id="KGVHNAH"/>
    <dbReference type="OrthoDB" id="1663665at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="446" mass="50972" checksum="742936710BD948FA" modified="2011-10-19" version="1" fragment="single">MLRHVGVAARRTAVLRCRALWAHVGTFPQAPISLRLSRRTVFHSTQALRSVRSYEQKTPQWTLDSPVKEVLLEDCAGLSDMSLHDFLMKHFGETFGSPCVSMRVFMGNPSFFLRDESLLTMVTESEPYREYVERYNREYELYKTMREGVDRLSAKGIYFLHQWESAAAANEVEDVDIHVKGKLNGALVNAKRSEEAMRVGNAPSGVEIDGAYDAVFNARWSYVVMSDEYSGKWLGMGVLDVAPGEQPHLWSEAQADVPYDPEEPWEGDEVPGVSGKLVMATLKSHKGWPYTLFNANASEIVSANVLRKYKGVHNAHLHIRRENLRVWHIVEKNIDEWLRDRGYVHPFIVIGTPGIGKSFATGSLLLYQLLHYPSDDLKVVAYFVRGKAYIFHREERRVVYYEEQRVALRNVNDMIRRGIESYIIFDIRENGSLFGKRPYLGALSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P1</accession>
    <name>F9W9P1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_46300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001334">
        <property type="protein sequence ID" value="CCD13945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46300"/>
    <dbReference type="OrthoDB" id="1663337at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390009" evidence="4">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="93"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="47309" checksum="E83FFE0D394FCB6E" modified="2011-10-19" version="1">MAFTINAISIIILSFLGVAMSQVKVEKDDNIEPFALMCRIYNVAKNPPINYVDLEEADKIVQEIDALNTSLMDQKRLNETEELWSSVGAQVKPTLTRETALAQLSLNQITQKAHTILEEIKKIKVSENIERAKAEFNQVIFGENGNESELCHATVKDVGNRTAVCGSPGAEEKGSHAGNNLVVDFFCLCAQRTDEEGVNQVCGFYVGRISHFYGWDDKNGPWGSSTMWASIKGGCSKHMHEHTKSTAEARHILDQFLKHLKMGGVYMWGESSSGKVEEGNQKAGMLGTAVGKKGATDGNGPVCDGKKGGKTGGRNVNPGGVCAYYGEDNQWENISWKKQLNIALNTVENINNQTATIQRDIEKLQMLQHRAEEMYETAKVISEFQNTVGVPEALQNATGNLTAFNTTRIRSYSYSRHAYFALPWVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U5</accession>
    <name>F9W9U5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001351">
        <property type="protein sequence ID" value="CCD14000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="12241" checksum="46C6C5C76D02367C" modified="2011-10-19" version="1">MGHTRTVTSHARTYAWSSLLSSLSHYTTGGSICCRGVQPKSAGFTHPSLLPTLHTPFSAASSIQMLTGISHGAVTRPAVQHSNKLHSELLTCGDPFSQSHSAAHIQALIQGHFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9V8</accession>
    <name>F9W9V8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001355">
        <property type="protein sequence ID" value="CCD14013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46930"/>
    <dbReference type="OrthoDB" id="1709701at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21117" checksum="2BE3F2135247793F" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVEVLLDGVASADSINLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPVPPYQPYQEVVLVGATASFVQVPYSTVGYLVNIPVTPRPWPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA60</accession>
    <name>F9WA60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001399">
        <property type="protein sequence ID" value="CCD14116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05080"/>
    <dbReference type="OrthoDB" id="1693232at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040873">
        <property type="entry name" value="SoPB_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18090">
        <property type="entry name" value="SoPB_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="249" mass="27465" checksum="329928B3B3B5C42E" modified="2011-10-19" version="1">MARGNAITLPVCGRDVKFTLEVLRGDSVEKTSRVWSGNERDQELLTEDALDDLIPSFLLTGQQTPAFGRRVSGVIEIADGSRRRKAAALTESDYRVLVGELDDEQMAALSRLGNDYRPTSAYERGQRYASRLQNEFAGNISALADAENISRKIITRCINTAKLPKSVVALFSHPGELSARSGDALQKAFTDKEELLKQQASNLHEQKKAGVIFEAEEVITLLTSVLKTSSASRTSLSSRHQLPPERQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA62</accession>
    <name>F9WA62_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001399">
        <property type="protein sequence ID" value="CCD14118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05100"/>
    <dbReference type="OrthoDB" id="1724279at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000525">
        <property type="entry name" value="Initiator_Rep_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01051">
        <property type="entry name" value="Rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rep_3" evidence="1">
        <location>
            <begin position="16"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17425" checksum="FA6D249408A0926D" modified="2011-10-19" version="1">MAETAVINHKKRKNSPRIVQSNDLTEAAYSLSRDQKRMLYLFVDQIRKSDGTLQEHDGICEIHVAKYAEIFGLTSAEASKDIRQALKSFAGKEVVFYRPEEDAGDEKGYESFPWFIKRAHSPSRGLYSVHINPYLIPFFMRVTEPVYAVSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAB6</accession>
    <name>F9WAB6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001410">
        <property type="protein sequence ID" value="CCD14177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05200"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390041" evidence="5">
        <location>
            <begin position="20"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="82"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="49013" checksum="62F3A8C808455887" modified="2011-10-19" version="1">MLMKFALVVLFFCAGVVCGQHPSAAEFNLFCRILAEANNMMYGPDYVYDENLDREIIKEMTVLYNATTGDMDDFRKTLWDTKDFFEEHPPPTHSESRKRAHREIGNLIKKGEEKIEENKKIAEKVNEKFNEAKLSVAKGLYGEHVTEVPKDDKNLTEILTNTSSIFGHNTSAKDSCGNGGANEAGKTLINDLFCVCAGEGLEAERPCHPKIWPPKSWKDKGQGSWTLIKFGSVGTPTLVPSFNESFQKIEHVCREEMMANDVNSKDMTALLREYVEMIGMGNKKTKKDKKIFGHSERNKGNKGANQVEECTGTGSNDNFDGPEKHNNNICVDYSHNLKDEKTKTYNITWHEKFKNYTKIMQDAKKIEERILKNRAALLLLKSQAWVAYSREKDDETSNLDDMNVSHLFDATQLPPSFPFPFLLFLFLFLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAE7</accession>
    <name>F9WAE7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1964</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001424">
        <property type="protein sequence ID" value="CCD14208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48550"/>
    <dbReference type="OMA" id="EAPETTM"/>
    <dbReference type="OrthoDB" id="1714567at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="293" mass="29555" checksum="67C89B6722B6D463" modified="2011-10-19" version="1">MEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAVEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAVEVADNADPEVTAADAVEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAVEVADNADPEVTAADAVDADREYSLLNVSYMECTLHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB62</accession>
    <name>F9WB62_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001538">
        <property type="protein sequence ID" value="CCD14493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14318" checksum="F5F724DE33A96A87" modified="2011-10-19" version="1">MKVCEAQYAEAADKVFPPQHAIYSKLEKVRHTCDTIEVSVKPHEATVLQWAKEVYFNTTAPGVLKAETPKEERKVHTMRRVQRFNGYDYQAWKDGPVVLDASSGAEALVCPRTGKKVRRSLWVVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB75</accession>
    <name>F9WB75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001544">
        <property type="protein sequence ID" value="CCD14506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14378" checksum="3B601E3347E711E6" modified="2011-10-19" version="1">MQPGQQIICTNAGNNKTHFQCISQHHNTPAPCRGQKSQDGQQVLHSFGLHHVPRVLGCAWCRAVVVIPACGNTRGNCTSAFYFIPSSGSTAPRQSPHCLAAYRNGERCDTSHHTPQNAVRPLHSHIGSHTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBL5</accession>
    <name>F9WBL5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1761</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43320</name>
        <name evidence="3" type="ORF">TCIL3000_0_52470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001198">
        <property type="protein sequence ID" value="CCD13591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001596">
        <property type="protein sequence ID" value="CCD14648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52470"/>
    <dbReference type="OMA" id="WFMVQFI"/>
    <dbReference type="OrthoDB" id="1643834at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="272" mass="33759" checksum="8D692E9F6C65F983" modified="2011-10-19" version="1">MMFTGFYIFYIYILYNFICFFFAFGINFLIYYLEFFTFLLFYIFFDFVSFSNYIYNYFGLLVNFNIIFCAYLFCLFYFIIYFLFCFIFFVIRCLFVVIVDFLFFNFDIFLSILLCDIVYLDFISLLLVYFSFIFNFIYGFFIFILILGLVFLLLFFVINLFFGFTFLVYGIHSNLINYIYWLYLIYSRSCYILMPSVLIFFKFVYFDVFFVFVFILVLFIISFFSFFLKDFLFLSLYFDIFNSLYNYDIYSYPIFYFNYNQFCITQLVSIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBX5</accession>
    <name>F9WBX5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2157</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001638">
        <property type="protein sequence ID" value="CCD14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53500"/>
    <dbReference type="OMA" id="STCANKI"/>
    <dbReference type="OrthoDB" id="1310068at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="33567" checksum="7E34322EE9383C2D" modified="2011-10-19" version="1">MEQRTSETRSARTSRNRRGRSGCHRCQRGVLMPPTVNAFSETARRRRGSPRDCSRKSSTTPGVVPELSEETLQQSVQTFRDAFILRAETLRTYSQFHNTVAYLHEVMQNQLGALWSTALQLDTDFLLSMQQKLELRDTDVIPDDIVIKGGFLEQLEAYEALLDEIKDGMEMLRSASVRFVACVLSDDEKRSIGIDPEKMPREDVLKSVGSRPTSGRLSGREGSKSNVESSPVKMPARRKSSAKEEVAQCKETSDVAKTTSGGNTAPSYARRRSTQKAVEVEDKINRWKVYSNLRQSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCC3</accession>
    <name>F9WCC3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_54850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54850"/>
    <dbReference type="OMA" id="GCMERIT"/>
    <dbReference type="OrthoDB" id="1063352at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="PTHR13768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="37208" checksum="20518715CAE6FAD0" modified="2011-10-19" version="1">MAAEEAVAQAITSQMILCPVEDEGRICQDGKETYVTQRRQEAEKIFEKAKMDISRGLSGCKDWLGACDAFNEAGGLFAELGLPREAARAFLYASIITRAFKDDEETTLALSLAAENLQLVEPSLAVNMLQAVAGLLKAAGFSFQAARCKRDSALLLEDRLGDAERAVELYKEAIELYGTKRFMGSFARGCMERITSLTVGLKKYTEASKLFIEETAFAPSGRPKTRQFFYSLLCMLAEGYGNNDRYFDALYFFRKRFNTLQEEERDFQRGKENKLIRQLIEANDNGSLTAFDTAVYEYRSSSTYVEDPVFEQLIDKCRSNLYEHLEQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCI6</accession>
    <name>F9WCI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001727">
        <property type="protein sequence ID" value="CCD14979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55470"/>
    <dbReference type="OrthoDB" id="1713679at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19768" checksum="7EEE349A4F67CE65" modified="2011-10-19" version="1">MTSRFSFICLPYPLFIHLQYFYQLMKKRYYLKQLYNHVMSLFERVLQLFSKMKLKFVKGVIMVLVLLLPFKPGGVRKSNEQGLRLLCSVLRASEIVFKGYRGNRIIEEAFYGREGGVRLRDGSVHLGWACSGKSLRTQLCTLFNGIDGLEGSFAESFVGITRFVCTPWGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ5</accession>
    <name>F9WCQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56160"/>
    <dbReference type="OrthoDB" id="1669527at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388980" evidence="1">
        <location>
            <begin position="27"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="43490" checksum="BEDEB6B22B3A173D" modified="2011-10-19" version="1">MTEGEVRLVYQLLAGLLLLCSEVTWGNKRQAIPTEVGESICSLSRKLKLVASWTVGQVAALKKTRDEYASKFLEWKLHFHGSPECGENDSILEGIRIELETVNKEIQKLPAKAIRAGALAAKSAGRLDEFTTVFANARKTGSVFIFTKTDSETSNYCLGSGGNQAKRRDLFDCFPTGGKVEMSEANLAKIPESMTDLSEPNLTAVIENINHSSMATHINRKYVIDAEAGCNLIKGSGGILRAALYNKLWWGGGILTIGKDFDGSLGVKDKFGPGEITSAKDSDSSKAFWTASPHTIPHLKKTLDAFQDFKNAATIIAEKISDIEKIEKQIELCLSNETMEEGSTQSCFKNAVKLNAELQAANALLARYHKEKGPLPSGSPRTHAQCVFTFCYLIAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD45</accession>
    <name>F9WD45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_57410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001820">
        <property type="protein sequence ID" value="CCD15196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57410"/>
    <dbReference type="OrthoDB" id="1706189at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22447" checksum="A0E6BF5AE88569C7" modified="2011-10-19" version="1">MRGWGRCEKASTRHGQKRSNGPIQENCWMLLYPRSRRSGETSRTPWEHHHDPTIAATKTRVVRKKRNHLRKHPGAPHRPHWKPLPVKRRIPRKGVCSSSPFPLADGSILIQPFGLPLPAVFLKAHPPSTTTISTIILIMVVHPVVSHSTGYFFVFPVFLLKLGKMRIKTLVLVLGVIRRSMEMSVRSGYYEHAFKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD99</accession>
    <name>F9WD99_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2340</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001842">
        <property type="protein sequence ID" value="CCD15250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57920"/>
    <dbReference type="OrthoDB" id="1703004at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21720" checksum="07F9613A5D08D323" modified="2011-10-19" version="1">MNSLAVSLFSVTWYWWILSHRARSVSLAGYLDEAQRRRFLMAVLSACWMYMISQMQVFSXILPVLKYFPHVVAKLTHCGPFGVVFLRFGYLQQNNRLGPLSFHNKEAVHKREVWNERFVGATPCQLPLRTIGVEMGNKHGHTPRCVSTDWCLASFLRGRRSMRPTSASTAFHAMEALMVTVSNKSVHLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDB8</accession>
    <name>F9WDB8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2349</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001852">
        <property type="protein sequence ID" value="CCD15271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58060"/>
    <dbReference type="OrthoDB" id="1268529at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="697"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1163"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1257" mass="136510" checksum="54D60FE216269032" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDH9</accession>
    <name>F9WDH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001870">
        <property type="protein sequence ID" value="CCD15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58620"/>
    <dbReference type="OrthoDB" id="212869at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21100" checksum="6A4392D75D234BB2" modified="2011-10-19" version="1" fragment="single">MVSNVGGSSGFAAAAKVLFDSAKKVGAVKPLGSTNKLYAQQLKRIQTQSRRRGGSLGSVSYSVVEFLESQRSSKAIPTRLPASLVKRVPLIDIPMQQSKKKEAVTQQKVPSKDIPNLEFIRKEAPRGRIQPGAAESLRAPSTSPSVGSLLLERVSPGPKKSSAKQEVHNLLSERSVLGAQKENEVFEAQPSECSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE58</accession>
    <name>F9WE58_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001955">
        <property type="protein sequence ID" value="CCD15564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06450"/>
    <dbReference type="OMA" id="LVMEKVH"/>
    <dbReference type="OrthoDB" id="727053at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="563" mass="59675" checksum="0FA03E945E5911E3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE78</accession>
    <name>F9WE78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein TCIL3000_5_5290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_60700</name>
        <name evidence="4" type="ORF">TCIL3000_5_5290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001959">
        <property type="protein sequence ID" value="CCD15584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60700"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_5290"/>
    <dbReference type="OMA" id="DRHECSA"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC90764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="279" mass="31289" checksum="4E441307F93D36C9" modified="2011-10-19" version="1">MHRSFEEGRMLRTHRRVLLDHVRPAPKHTKLDRLGESLLAQFRAGTSKPFGWLHRVLTRKTDRLECRWCTAKDIGGDAVEGHTLAKSAVDSANAQEFGIATRQSDPIICPLCHMVCARRQAGVVHLVKIHGLERDYALAMTKKARRAALTYKNGCTCHVCGDAFERRGLLVEHMAQHPPDGILAEEKRPKRAREGDEADDGKAFKCCWCAKRYTVYARLRKHMIQKHPEKQLKSDDIPVEQEASSDSDGEPVQENRISYARSVIGSSKARHGSPGPSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE92</accession>
    <name>F9WE92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_60840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60840"/>
    <dbReference type="OrthoDB" id="1727325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394706" evidence="2">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="26512" checksum="BBBF07BC1285AF6F" modified="2011-10-19" version="1">MTTTMSRVLHLMTVTLLCARVGMGQASDDDDCGGQSIPQKVEGVQTMCDVARQLRALETASQSAVAAVVSSAREASEAKERAEKAVERAKSKKRGVDTATEAAARAAAAAQRAETVASDARKHAADLTAASKDAIETTDESLRLLATCEKADEPIRTAAKKCTGAAAEVTSKSLESAFDALAELLPDGADDIREHGAVFVKGLKSLEDDVRTAGEAKSEAEKAEGDANDAADGARAVLTGVCVLLLLAALHFSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF7</accession>
    <name>F9WEF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002005">
        <property type="protein sequence ID" value="CCD15665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16842" checksum="103FCC5787A7D33E" modified="2011-10-19" version="1">MLIPDTFYYKNRTPLGDAGHLNVVPGYSTPSRRQPSAGITPVRQDGVGQEADGYQRGSMQQHRHSWVNEAGRILPCTCGRATLDARRFLLPVRGDVGRNPGPMIRGAQWNAGVYPRRSELPWTGSFTRVTYHSVRCRRHAWCRRKVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEG1</accession>
    <name>F9WEG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002005">
        <property type="protein sequence ID" value="CCD15669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06870"/>
    <dbReference type="OrthoDB" id="1708569at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19308" checksum="029A5EEE5C832875" modified="2011-10-19" version="1">MISRGGWRDTCCNISHALNPSLGLGVPIPKLSSTLPTRLMRFLGKCETLCTPLNPPACCFGRPFRQSSGHKKINDSGDFLRHNSITSSLLEHCLRPRATAQIPKRHPNGGPRGACVAPWSKYRTSKQWSAGSSDGAYLSGCPKQAQPSTKQLCTVMLDRNTPKRAATISVDRLHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF30</accession>
    <name>F9WF30_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002095">
        <property type="protein sequence ID" value="CCD15898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01010"/>
    <dbReference type="OrthoDB" id="741871at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="45660" checksum="9F6C4FBB8197AFE9" modified="2011-10-19" version="1">MDSQLPNFDPRNIHRNIKAFTDCYYTALRRHCPRGMIKDGPILWDREIIEAERYVETLKSRYLNMPSSAQLAALNEAKDKFMDTVRQRLNTTLRHRLGKLSPGEHLSWKYISSRNRATTPLADSLLLSVGHKQLSTSRHIANAFNRNFFPPSQGRSRLLRFTIRRSFKRGKESSPLSSSALSLGFSPHFSSLPSLGTHIGLPFDAASFPTLSSLTALSFLDAPFRLAELLSALRDTPCGKAPGLDEIYAETFGHFSEKTVRYLLWCINQSWLTGIIPVQWRRATVIPLLKLGKRPDDINSYRPISLTSVICKVAERMVLRRLLWVWTPHAHQYAYRKMHMTTMQLAHLVDTVEHNRNHYFDVRLPKRAALAIKCTTDLIAHCWFSLISVKPLTQSTNMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA1</accession>
    <name>F9WFA1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728734at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15298" checksum="1059E84EB2A47490" modified="2011-10-19" version="1">MSNCGVTSELHAAHCEGACVRPVCAGHGGCVWTLDSTVEEVLLWKYGNVTEAHLHKFLLDHFGSTFGLPDMSLIAFMNDPSLFVTDTQVLSGITSSAAYVDLQAMLRAVNVLNSAGIITLEQWSALSDAPAVIERAAATTTSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFJ5</accession>
    <name>F9WFJ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002154">
        <property type="protein sequence ID" value="CCD16069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10330"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389062" evidence="1">
        <location>
            <begin position="27"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17167" checksum="DE68B19A98D88413" modified="2011-10-19" version="1" fragment="single">MMMWGNKKNVTYMVVLFGVFVEIVKSKSVHYNGQEKGLLCQVYTAARHVLTHAVEPHKRELEEAIYGPKDRAHFTADGEVNLKWKCSNAPRGRGGLCTYFNVDGCFAESLYGTFMCLCTPGVRTESGKTYCGVDASRYSGTWSGGWSWEESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU9</accession>
    <name>F9WFU9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002188">
        <property type="protein sequence ID" value="CCD16179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14949" checksum="F9D247895342ABB1" modified="2011-10-19" version="1">MLPISPMEEDRVTNDIFQELWLVLMNPSLVGTDQWYLRDTEMYLLLMRCLIHRLDWEAAVHLTVKTMESLTYTYMMDHELTLMFMEIGDPAGCLAFKVATKLFDGRIIKDGLNKREKFHQERFDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ1</accession>
    <name>F9WFZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002205">
        <property type="protein sequence ID" value="CCD16221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11690"/>
    <dbReference type="OMA" id="DERKYHN"/>
    <dbReference type="OrthoDB" id="1654509at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21112" checksum="EF8FE2C26FC88D8E" modified="2011-10-19" version="1" fragment="single">MEGGGVKRTRDEMEGEAVAPVEQAEAAARDQVTAATDAAARPVAVRHEVVAGASGRWTLDSSVKEVLLEDCGGLDDMSLHDFLMKYFKRTFGVEDTSMSVFMDDPSVCVSDEAVLRRITKSSAYREYELYKTMGEGVERLNAREIFSLRQWEGAVAANEVEDINAYVRGKLNAALLSVRRNEETIRVGDAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG23</accession>
    <name>F9WG23_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_12010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002219">
        <property type="protein sequence ID" value="CCD16253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12010"/>
    <dbReference type="OrthoDB" id="1673298at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="2"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34651" checksum="C5578617AD6AEF47" modified="2011-10-19" version="1">MSWRKAALEVNENKNFEKLPSGSTAARLARHKLKRIGSQMERVIEEIKKKSGASRLEEIAKLFERAIYGNTPNVKDLNLYKGAVNRTKTCGGETGFSGKVAHAGKSLVLDFLCLCGKAEDGEPKVCGELVNVNDAGNWNTTTGMNGESNWNIIKGSCENMEFPKSCLAAEVLRAVADFESVLSKGGKTTAPVGKPGFHVYPGVFGICKYARERLSPPTVGCDGGKDYHSCICVYYGVASDWKNIQWLQHMKSALGLLEAAEATQLDITHLRMLQSRAEEIYDEAKMTLEHENPKWRSGSQSYYSCLFLPWALVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG74</accession>
    <name>F9WG74_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002242">
        <property type="protein sequence ID" value="CCD16308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="111" mass="12399" checksum="3119033171B0E847" modified="2011-10-19" version="1">MAAFSGSTDLPTPPRTSRTRHATRRTWKASFVSRSSSSTMRSSPTRRPSTPRTFNTPPMTSLRPTPPAKVTKETPAISPTPLRRRSSKRTLTLRGKENRRGVGYFPLFIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB2</accession>
    <name>F9WGB2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002251">
        <property type="protein sequence ID" value="CCD16346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12850"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394753" evidence="4">
        <location>
            <begin position="21"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="16"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="444" mass="48701" checksum="2265B645877FCD23" modified="2011-10-19" version="1">MNPVVLLLVAAICSSVACSAEPSSSEGPNKKQFNILCRIYRAVSAAPTSVFDQGEVDRIRDDIDAINASFGEHRWFHGIAEVDPHADPDEITNEQYEQAGDLWPRWKKAVEEVMTGEKYKKLPSSSPVVRVARFKLIKIEDRVEEILRDIREKSESAGLGQLNKTLQEAIFGEGSEGKLLPYRYSNRADNCGKISTYRQGTNTAGGKSMAHDFICLCATNKGTVKKPSEGGDNCLGGVASTKGWEQGDRGTGNLETIWKSIKDECSQMVKRPSSSSNLEDALHSFLDEIADKRGIKAPVLYGVLGRLRPTSYRSGAACNGENGSQLLEGGGACVIYKVKNGPNQEPDIPWFDKLKEAIEQLERIKNTTDSIRHDITELKMLRSRAEEIYETAASTADVASLLHAHLTGNFSEMLGPSAPGWLQSLSAVGSPNQKSIFLAWFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGC3</accession>
    <name>F9WGC3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 488</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002257">
        <property type="protein sequence ID" value="CCD16357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12950"/>
    <dbReference type="OrthoDB" id="1708244at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="21843" checksum="7D232929A321419E" modified="2011-10-19" version="1">MTAHSMKGWPAGSRCRGDRRARSRLNWGKHTNLMELPRNTARSLCRWAALKNKSVHLAHHMWGGACITGRRLHYTRADTAGGENRLPLQQVDISGLTLGWIRQPIDFAAGDRLDRVRDIKWQPTAAQTGGRESHSRISPTDAQLVKASTIETVSIEKTTERWVVPFTAVEGNLPSRDALLFCAKPRTSRRIMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD6</accession>
    <name>F9WGD6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01460"/>
    <dbReference type="OrthoDB" id="1677632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395020" evidence="1">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="32802" checksum="1B18E673F2D1DE67" modified="2011-10-19" version="1" fragment="single">MIIKTTSVWLIMAGFFTLCSGILCASSYYPKALPTEAGGSICSLSRKLKEVAPWTQEQLETLRKTRDAYASKFLDWQLYFHGSPECEVNESILGKILTALVTVNKQLPELHTKAILAGALAARSAGRLDEFITVFARARGDGPTFYEKSSFCFGYKGHPATRADLHDCFPTGSRFEIGETNLAKIPESTVDRGEPNLASVIKNITHSALYGHWYRYAMDSAAGCNLIKGACDGILKSVNLEKPLWWGGGILTLGKNFSGQMGRDEFGPGEIANTKDITANWTASPHTIPHLQRTLDAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT4</accession>
    <name>F9WGT4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002319">
        <property type="protein sequence ID" value="CCD16521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01660"/>
    <dbReference type="OMA" id="NEVSICA"/>
    <dbReference type="OrthoDB" id="479815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18412" checksum="68F1504586BB4A58" modified="2011-10-19" version="1">MYAARVQDQEAKGLSLAGLTFRQRYIEFCRQGGIKPNSMLMRLFPDKQGISVMRIDTSMNYVGPKGFYPILQALRGNAGLEYLNLSHNNLENDEVVELVNVLLTDSGASLVFLDLSNNPVSLVGGAALLRLAQSNPLLSTIRVKGTLIPQQVCRTIQEACDANTARAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGV6</accession>
    <name>F9WGV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 558</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002335">
        <property type="protein sequence ID" value="CCD16544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14580"/>
    <dbReference type="OMA" id="HVIATEM"/>
    <dbReference type="OrthoDB" id="1653592at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1397"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1397" mass="159146" checksum="D29C7D3A6CE79666" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB2</accession>
    <name>F9WHB2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_16080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002408">
        <property type="protein sequence ID" value="CCD16702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16080"/>
    <dbReference type="OrthoDB" id="1677749at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395052" evidence="5">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34886" checksum="02756778F0B8022A" modified="2011-10-19" version="1">MMMKIWIMVMVTMGVAGATNHNGPQYTALCDLLAKAVFMLEKKRGNLSEPLEKALERTIFGKDSGATVEDLRKNKLPSGYSGTERGYLCGNPFDPATHKQWPLYYPGYSGLHDMLCLCTPGENGWPLNKQVAGADKLCGQDIKTWGEDGYMGWASGGYEDGENQLTATWTNITLPCLKGGDGAGDLKSALQKFKKKLGEPVQKDPPYEPLGEGNFSDNFPCTGYSDRGVCVAYYNNTDPKPWWIQLEVAIQEDEKKKLDEEKRKLQTQSSVKATDLTSPTNTTWSRRNTTNITNRKSGSAIPQQLWLLDAVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB5</accession>
    <name>F9WHB5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002408">
        <property type="protein sequence ID" value="CCD16707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16130"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389135" evidence="1">
        <location>
            <begin position="24"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="255" mass="27518" checksum="0EDD058936D77393" modified="2011-10-19" version="1" fragment="single">MRSMKFGIVLMLVTVIGVNVVMPSVTVTNHNGDKHEALCSILASAVSILNSGRGGSNLQGALRRAIFGSKTGGNITTLLGGLPSTHHDPGNRKNWCGTCTHSDSNNYPGKSIPHDLLCLCTIGENGYPFTSYGLVRQLCGRSATDLGCEMGGRSRCNNGNGHGWSDSKHGEQARRHLSTTWDSVVNTCLQDGLNLDLDKARQIIGTKLKIEEEYSSPIWARGHSIGSCGGEWGGICVNYDSWCDPQTYPQWLKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHH9</accession>
    <name>F9WHH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002438">
        <property type="protein sequence ID" value="CCD16772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16730"/>
    <dbReference type="OrthoDB" id="1724637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19147" checksum="5E30033023F03092" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMFIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNNFVFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMSFLVFCHPARCKTVFATIISCFSVSFLVFHHLARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI18</accession>
    <name>F9WI18_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002516">
        <property type="protein sequence ID" value="CCD16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00080"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16696" checksum="03B90D721F0DE69A" modified="2011-10-19" version="1">MHHAIGEPMRSHDASALQLTKKIYLDTTASGAFRAHVSRKEKVHTMRRVKGFRDNDQRVWVERSMLLDVPSGALAYPQDSFGKKAALGVSAPVCSYRTQCVAMGAVLERLVKSIGRNAARKTKAAVFLDSLSPLMVLNTGRAVVIDTARRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI21</accession>
    <name>F9WI21_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002516">
        <property type="protein sequence ID" value="CCD16966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00110"/>
    <dbReference type="OrthoDB" id="1710421at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390413" evidence="2">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="20218" checksum="DDF5B6A48C797893" modified="2011-10-19" version="1">MHSEWRIICGIFLLLCCTQRVEFYAVRSIQEAMMLTGIFTPYYFETWLCEIVCLSLHNCSAPALLFVYFYRRNEREEWREQLSNIGVHPLGRLFRLVLHYWALNTIVLPHIVHISTTVPFAVLTPLIMYMFFLISFGTFLVVEDLCYFPLLLFRLPFVKGGAPQHMVSLVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WID0</accession>
    <name>F9WID0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002568">
        <property type="protein sequence ID" value="CCD17077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19300"/>
    <dbReference type="OrthoDB" id="70382at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="377" mass="41911" checksum="43702E73B2C4884C" modified="2011-10-19" version="1">MVSSGTWQNRTFGYTSLCSNDVIPKIADEDTPRQHSCRNTDMSIPQFHTLMQTNPSIRMCSMSAQSERGNHVPQQEELSKHNSLHMPLGSSGKRETVAFCRYEQQHPCGGTLTGSGNRIEVQAGLDDEYHQDYEVFDALSITTTSSCAFGLGLGGLKQLSATGNEMRFLSLLNQVSSTPGMEENDRELPNELEASKELDCLAEKTTTLHNKSVSMPSVMQNADASMSGPISFTSGVAGAFNPSVTYAFEEHVYTMKMKMKHDNSLSISRHFDKARNLYDESLTSCVEEVLFADKDEESSPGTCTQSPKEKWEHAVVAPQHGQHIIGFGCYFTFPQWLGEPYSSCLPRSREAAVWHWLKNVIDPEERIEREGEGNKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE6</accession>
    <name>F9WIE6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 777</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002578">
        <property type="protein sequence ID" value="CCD17093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19450"/>
    <dbReference type="OrthoDB" id="1737026at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18910" checksum="B0B6355D24CB90FC" modified="2011-10-19" version="1">MIIYIYIHMRVYTHVGVCCERLLLLCARVRTVPLARANYSHPHPPPVWCVLCVGNRTWWGAVVVTATSSKTHLGTRTCPNTRPPCRSLSLVLRRCLRLCAPRKGKKEVVWRRRVLMPPDAYCVRTGSLFSIFFFSSSSFSCFPTCVGRVEEEVCVFGGRRCSGEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIJ1</accession>
    <name>F9WIJ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 801</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002604">
        <property type="protein sequence ID" value="CCD17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19860"/>
    <dbReference type="OMA" id="QICTEDC"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23113" checksum="94338DA5CF5A4D2F" modified="2011-10-19" version="1" fragment="single">MGSTHLPKLLGVPLDTRMNFNSAATSQCTATSTRIAQLKSVAHKKAGPLPHDMRTFVIGYGASKLLYGSEMIWALADDSAKNAMMRTYASLARIVSGTLSTTDPESALLEANMTPLHILALRARFALFERVRSCQKEWIRRPPPEPPPRKGFRISPISRETMYSLVDGLTEEYGVNRNSVRERRFFKSAVPPWSVSQANKVTFGLTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIM2</accession>
    <name>F9WIM2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002617">
        <property type="protein sequence ID" value="CCD17170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14918" checksum="5C7BBA46EF10171B" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGESPMSSARARRLFANWEAVSVQQEVVRLAYTEREAEDFVTQLVTRTIAHGNAKRAMEREEIYVPIEEELLRATKWRVCAGEEQSHSLHLRRACGGDCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD6</accession>
    <name>F9WJD6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_22590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002713">
        <property type="protein sequence ID" value="CCD17440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22590"/>
    <dbReference type="OMA" id="HANTDAQ"/>
    <dbReference type="OrthoDB" id="280961at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="7"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="528"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="948"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1077"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1324" mass="147367" checksum="42D0DF3B6629BBBF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJN1</accession>
    <name>F9WJN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002747">
        <property type="protein sequence ID" value="CCD17538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="11887" checksum="9A408BDC953E72C4" modified="2011-10-19" version="1">MLVDTSTSVVVDNLLQPFGPGAYSGSMGLDGGIKGLRASEGFRFCRDRGLGKGCCQSGMGRFLFGCGLDAGKKARHGIGPGDGGRGFVFIPSRMRGPTNVIGIVSTSLTIPNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJT6</accession>
    <name>F9WJT6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002768">
        <property type="protein sequence ID" value="CCD17594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24010"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="446" mass="50446" checksum="F5505FEFC0FCF821" modified="2011-10-19" version="1">MVRNTLKSRQVTMKIPEYDTNTEAVLVEVILRNGSNMYIASVYLPPPAVVTSTLHKLVTTVPASSPFLLCGDFNLHHPLWALKGDEAPSDTAQKLLDITLDANLSLANEPGFTFARGPTERSCIDLTFQRFLAVECWTARVTIHSDHFLIKFSVRASHRNEIPPAAPVRRRHFYSWKKCDWDSFRNKMDSQLPNFDPRNIHRNIKAFTDCYYTALRRHCPRGMIKDGPILWDREIIEAERYVETLKSRYLNMPSSAQLAALNEAKDKFMDTVRQRLNTTLRHRLGKLSPGEHLSWKYISSRNRATTPLADSLLLSVGHKQLSTSRHIANAFNRNFFPPSQGRSRLLRFTIRRSFKRGKESSPLSSSALSLGFSPHFSSLPSLGTHIGLPFDAASFPTLSSLTALSFLDAPFRLAELLSALRDTPCGKAPGLDEIYAETFGHFSERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX6</accession>
    <name>F9WJX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 963</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002784">
        <property type="protein sequence ID" value="CCD17636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24420"/>
    <dbReference type="OrthoDB" id="1750749at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17967" checksum="431D4077B048F75D" modified="2011-10-19" version="1" fragment="single">MHINHFPSQSPASGVPRREQPTQLLYESAHRAARRAAVPRGGHLHQHQRHGRYAALLCRQPAPALHEKEALHQRELRLLRPVEPTRLDFQRCVKGGKVVERGRHAAPAPSAAEHARAGARGLTFPWEILQVPSQFILNVDQREDPYPCYGLPRWGRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK82</accession>
    <name>F9WK82_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_25270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002823">
        <property type="protein sequence ID" value="CCD17744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395129" evidence="4">
        <location>
            <begin position="20"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="82"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="425" mass="48488" checksum="C9C26270CF7ABCE2" modified="2011-10-19" version="1">MLMKFALVVLVSCAGVVCGQHPSAAEFNLFCRILAEANNMMYGPDYIYDENADREIVKEMTVLYNATTDNMNEFRKTLWVTKDFFEAHPPPTQSENRKKAHREIRNLIKDGEEKIQENKKIALEVNEEINKAKLSVAHGLYGDHVTVLPKDYANITKILNNTKSIFNSDSNVKEGCGSGEKNKAGKTLINDLFCVCAGEGMEAERPCHPKIWPPKSWSSNNGNGKWTLIKFSTENPPQLVQSFSESFQKIEHVCRGEMMKKSVKTKNMPALLQEYVGMIMGWDSWQSQCQKEKIFGHSERKKKEQVTKCTGEAGSHAYDGPEKKNENICVDYSNHFNNGKYEIPWHEKFKNYTTLMKSAKDLEEKILKNRAALLILKSQAWVAYCREKDDETSNLDDMNVSHLFDATQLPPSFPSFAFPFLFLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3H7</accession>
    <name>F9W3H7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1053</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000411">
        <property type="protein sequence ID" value="CCD11695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26500"/>
    <dbReference type="OrthoDB" id="1683201at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="31433" checksum="378E719FCA90B378" modified="2011-10-19" version="1">MTLSEVISGFVRITLSEVIPGYMKMTLSEVIPGFVKITLSEVISGFGKMTLFEVISGFVKITLSDVISGFVKINFSEAIPGFVRITLFEVISGFVKITLSDVISGFGKMTLFEVISGYVKITLSGVISGFVKINFSEAIPGFVRITLFEVISGFVKITLSDVISGFGKMTLFEVISGYVKITLSGVISGYVEIPLSDVISGFVKMTLSEDIPGFGKITLSEVISGYMKMTLSEVISGFVKMTLSEVIPGFGKITLSEVISGYMKMTLSEVISGDERGYVSFERGLGKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L8</accession>
    <name>F9W3L8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1074</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000434">
        <property type="protein sequence ID" value="CCD11739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26920"/>
    <dbReference type="OMA" id="MTFNRPR"/>
    <dbReference type="OrthoDB" id="911088at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="417" mass="46947" checksum="7C58B54ECB470DA9" modified="2011-10-19" version="1">MYRRELRSSVATRCRWLSLSRRAFYSGLDDSRIMRLRRSSIVFNKPRGRDSLSLWFEKRVRILPFTSVSDLYEFPSASSVAENTYKSTARPPRVLVVELLLLEDVETAVQYPASNPMYYAEWPEVPHDVEEKDYEVHPGTQSSLADTATGGYALSFSNRRHLQQFGDTTLLYGSFVRYGADNVSAHFSTALCINPFLSVDRFRREEAQVEMISAYRNILCEATEVPGGPADIIRIPALCCDTCGPRFHHEIGKLNQQALIKGFHRLGTGAKELLALNPQLSVELLVPIPLLQQFETAFLEEAWETPESTINPGRTALYPGLAPPRSLLPLEGWTGRRQELVDAIESGGRSLMSGAKRALDGTPISDREVLAELRLFGREKEEKAMLERERATAVQQGYETEGDRSVPPLRPGINQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3R5</accession>
    <name>F9W3R5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1095</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000457">
        <property type="protein sequence ID" value="CCD11788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27330"/>
    <dbReference type="OMA" id="PHENERK"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="714" mass="81918" checksum="97B1A0B1223D90A1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z9</accession>
    <name>F9W3Z9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000498">
        <property type="protein sequence ID" value="CCD11880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28190"/>
    <dbReference type="OrthoDB" id="1731250at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21624" checksum="9F05B8004BDF8F2A" modified="2011-10-19" version="1">MWMCVSQMRGRLREQLLRNSWDLFSHHIKTLGDRAKKELPVKVEAIVRCILNLALRHIQKWAHTQEQAQISMSSWSWSSPTPQKEEDSTCSDVEFLGMALPRRRKRAVPQAPPRGQEVQPEVVVVRETIPTRSPPPLPAPTQREEPLQETHVPEVEVEKAPTARFSMWNMEKVWKSLSCKASRTRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W464</accession>
    <name>F9W464_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000519">
        <property type="protein sequence ID" value="CCD11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28860"/>
    <dbReference type="OrthoDB" id="1725599at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17235" checksum="0804E4336EEC710A" modified="2011-10-19" version="1">MSVQRSNEASDRLTHQVASTPSTQRQPGGTGDSEMREVVWKVFKSFKGACLVDFLTQECGKTHGACNPNAAPAAFMEDPSHYIEEDERRKEAVEKLPEKLHHLKGCIFRDVPFLRAVGITTGGGLGSSSFLPRNAYSNHQLHSFTCMWLSSPRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A3</accession>
    <name>F9W4A3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000533">
        <property type="protein sequence ID" value="CCD11992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15694" checksum="20CDBC957DBAB2BB" modified="2011-10-19" version="1">MLFTCLHHGHYCFLILVNFILTRIRSLVNDIVLFWLSLLYGCFASVCPFSLPYDAYFLQHQRRFNFTLSASSPSFSSPFLLDAVYMGYLFQSVVDGQPCAPPASHFSPIHPHTHGNCGPHYMHGQHFFPHLSLSTPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4B7</accession>
    <name>F9W4B7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trypan_glycop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_29310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000538">
        <property type="protein sequence ID" value="CCD12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13702" checksum="4E7258DA4846D4CE" modified="2011-10-19" version="1">MKLLDWQSKFIQSKPKGSGSEACKITGLLFRQVRKEIDKARAELEKLEKEASKAAAFAASSAGRLDEFITVFANAKWSEGGRKFCLGKDKAATTEELKDFFRENDFSEESLVDISKQTNDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4B9</accession>
    <name>F9W4B9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TCIL3000_11_9110</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_03030</name>
        <name evidence="2" type="ORF">TCIL3000_11_9110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000539">
        <property type="protein sequence ID" value="CCD12008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.9110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03030"/>
    <dbReference type="OMA" id="ALVMHNE"/>
    <dbReference type="OrthoDB" id="1024692at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC95453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="272" mass="30233" checksum="976CF6E0348FA2EF" modified="2011-10-19" version="1">MSAPAGRALIRCQCSRAASLFSRRGYHGLFTVRRQFSFTKPKTPRVNLEEVRFDKQSPRYVGTVFGIPADAVVFYAKVGVAVASVCLVVSVFMKGYSFLARLNLGTVARLGFISGFLSCMVLNGVFVGVVRRIRINPNAVYNQSIAIVMQNEKVVQHLGTHPRTGDFKAYCLSGGFRLPLIRRIRSGSYELSDLLGLKPRKLQMMFILRNQANGYEGFVTCEVRRETTGFLSSVNTYKSLAVTLTDSSHSSPRTIVVIGRPEDVVYRGLMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H4</accession>
    <name>F9W4H4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1182</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000555">
        <property type="protein sequence ID" value="CCD12066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29850"/>
    <dbReference type="OrthoDB" id="1724646at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="20394" checksum="94CA86E0296D8232" modified="2011-10-19" version="1">MSVPLFYPSHEFNLIRQESGVPCSRFLQVFIGFRLPRHKLCRCVSSFPSARNTLPFTKTKQNIYIYMRVKRQERGENTLFALVQAQSTASTPSRFPHFPSPPFPFLRPYIPLILPSHTHVLHLPLFPLHAHTHKKIIDWIFFLFLETRGASTNIRNSHGRPVTSLNLPFHSSFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4I4</accession>
    <name>F9W4I4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000560">
        <property type="protein sequence ID" value="CCD12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29970"/>
    <dbReference type="OMA" id="YWRLWES"/>
    <dbReference type="OrthoDB" id="370051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PTHR11246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="803" mass="90831" checksum="BF5A8C24251BB4E5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P0</accession>
    <name>F9W4P0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1207</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000582">
        <property type="protein sequence ID" value="CCD12134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30480"/>
    <dbReference type="OMA" id="NCETWKA"/>
    <dbReference type="OrthoDB" id="1335683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="284" mass="32013" checksum="42B946F1F69B9B79" modified="2011-10-19" version="1">MLIDHEHRAIDFSDNTTGKLSVHILKRLRDAIDCNDFYCNLVFDNNVFTDDALGILAAILKGCNPIERLSLRSCNLTDLELVHLAQAICTRKSICHLDLSKNPGITSSSCAEITRIIQNVPSLESLLLIGTGLQEKGCSYILQALERNPTIRVLELPFTVGYRVLDKARLIIEKKTNKPEKAGDTLEGSKASHVDDNRMQHSQLLKSSVCLPSLEYLPLTRMSKGFGNKCNNSYVEDLLELPQWADPSIMNAAVYLKVLDKRCEMLDEHIKDRHRRMLARRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R9</accession>
    <name>F9W4R9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000597">
        <property type="protein sequence ID" value="CCD12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748158at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13121" checksum="94178E25C4D58EC9" modified="2011-10-19" version="1">MGSVRCNVLACVYVCSEISKCVRCGVDCGRWRYLYPFEVVVQLLPCVPRLRRCGVAVEWPTSSRCAVARGLSDPTGHFSSAHFLFVPTPPRSSQGLCFLHSRHKFVSAFRLSAKGINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S7</accession>
    <name>F9W4S7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000599">
        <property type="protein sequence ID" value="CCD12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30810"/>
    <dbReference type="OMA" id="GIHIQHF"/>
    <dbReference type="OrthoDB" id="147365at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="DUF3883"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3883" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1661" mass="183030" checksum="36FBB3085DE853D7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S9</accession>
    <name>F9W4S9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1223</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000600">
        <property type="protein sequence ID" value="CCD12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30830"/>
    <dbReference type="OrthoDB" id="1717457at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17816" checksum="E2A4D30FB0C162E0" modified="2011-10-19" version="1">MERLSSNLCKFQHRLSSNTVHFHPVNHTRLAMRARHIAQREYDGVALSCSHPRELRVLRIFLRCGLPWCTLDVGRDSMLPAVPSAFQSIGFLFRAHDGAIQNVSRCLFQTAQAVFHSTDPVYSLALVRCGQAVHIGTYLTSVPPRRPSFSLPGSAFQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z8</accession>
    <name>F9W4Z8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000637">
        <property type="protein sequence ID" value="CCD12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1885857at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="551"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="909" mass="101942" checksum="44A8FBC795B68994" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W533</accession>
    <name>F9W533_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000651">
        <property type="protein sequence ID" value="CCD12280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="103" mass="11480" checksum="EF66C2E820E54B7B" modified="2011-10-19" version="1">MAEKCQPEKLLTSGCGAHPTYPSHAVHVCVPTLTRSDWYALTPHSSSDSVSSGTPDCRPHRVERRIVRRRPPPRTPHGRTRISMQCGCCQPISICTPLTLTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5F3</accession>
    <name>F9W5F3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000709">
        <property type="protein sequence ID" value="CCD12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="13787" checksum="4EFEC31BA989B5EC" modified="2011-10-19" version="1">MWAGCGGGANRGAAFHGTGDFHLSVIVGYGAHQPFLFSPKDRKDFFSVCIYSARAPLDARLFSVLLKPAGNTDRNADTVLASFSKIVKQTACNKKAFFPSLWEATGTANDCAEGDGTSNKYGDRPLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G7</accession>
    <name>F9W5G7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32990"/>
    <dbReference type="OrthoDB" id="1679272at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29910" checksum="61EE16F33AD16764" modified="2011-10-19" version="1">MTGAGKTNHSEKQNYLSRDKRRTRLAGDISTMVFVSHSRRRQNAPPQFALSVAYPCLLRPGHHNWKACGKREQRDARQSFSIPPPILSGTRAVARTGRQHNGTDGVPIAVLGIDTGRHSSDQRWEVPFICPRTKRLRNTAWHVGASCGEWHVTNITTHAPNPFVAFSLPSMCGSKYHNTPFDLSLNCQTASSRSTCATCRDHAAHTSGCCQTRHGDHSLERVAAVKCAEPTTKPNSALRIEEESLKFHSSTSTYQKAGIAAWWCARTSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5K2</accession>
    <name>F9W5K2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1335</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_33330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000724">
        <property type="protein sequence ID" value="CCD12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33330"/>
    <dbReference type="OrthoDB" id="1372287at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="15"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="201" mass="21731" checksum="119A146B1D827F84" modified="2011-10-19" version="1">MSLTTIQVVQPPKEHEYIASFFSGCLAGVCSTCITNPLDTVRVRLSVSRSITGKSHKSLMYTVRDLFQTGLTHGFSRGLVANLAASLPSNGIYLPTYHCILDNLAVSGLNTNIRPAVAACGAVCVTNMVLAPLFLVKTRVQVDDTLTMPQAFRKVMQTDGFLGLYRGNMTNILGRIVEEGLFWSIYELLSAAGKKLISGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X2</accession>
    <name>F9W5X2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_34420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000791">
        <property type="protein sequence ID" value="CCD12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34420"/>
    <dbReference type="OrthoDB" id="1543029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16826" checksum="C57216BF40EDC769" modified="2011-10-19" version="1">MEAGFQLALESAPFLLKGAYYTVILSLGGMFFGLLLGFGLALMRLSRFKLLSWTARVYVSFFRGTPLLVQLFLIYYGLPQVGIELDPIPAAMIGFSLNMAAYACEILRAAIASIERGQWEAAAXIGMTRAQTLRRGILPQAMRTGLAPLGNSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6G7</accession>
    <name>F9W6G7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1465</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000868">
        <property type="protein sequence ID" value="CCD12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36250"/>
    <dbReference type="OrthoDB" id="399463at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="248" mass="26605" checksum="11DC6299E81CFF7F" modified="2011-10-19" version="1">MEYSTEPVAVFFESGELCPEKALRFCGEEASGVGQVEGPPVHPREALRQLHKATLEKQLASDGPPLTLSALINLFVSSAFLDVGDDLMVAILSALNSTLLNLSPRSASSSSSAGPRCVTPLEASSVAVALARVESIVTQLGKTSTAASRMKEEMGSVERALLPVLQPDALLARGSARCVMRLLCDCPSWTRRCGLEEGCLRALRDHAGDGFTRANLERLLRHNASNLLLLPADVKESVERCLVELPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P0</accession>
    <name>F9W6P0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_36880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000901">
        <property type="protein sequence ID" value="CCD12847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36880"/>
    <dbReference type="OMA" id="MVVQYAL"/>
    <dbReference type="OrthoDB" id="1057964at2759"/>
    <dbReference type="UniPathway" id="UPA00253"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="294" mass="32908" checksum="9568FEB714F2AAE5" modified="2011-10-19" version="1">MAGQPPLHQELRAWLEEYRKQRSFNPRTWINEKCAKLNDYMLRNKLQGCVTNVSGGVDSAVVLMLCSQAQRMENSPIVRNIGVCQPICSSPWALERGLENIRASGAEKVVIDQTVLHGQLSQSIEAAVGIEGNDFARGQLRSYMRSPAVYYVAQLYGQKGIPTIVMGTGNMDEDGYLGYFCKAGDGVVDVQLISDLHKSEVFQVARELGVPANTVEAPPSADLWDGQTDEQELGFPYDFVELYTGWFVHLSDREREEKKCLLSPEALHELETYTQMCEKVHRRNAHKLGGIVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W746</accession>
    <name>F9W746_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000980">
        <property type="protein sequence ID" value="CCD13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38230"/>
    <dbReference type="OrthoDB" id="1669022at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389950" evidence="2">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="41697" checksum="A585029BFE5B8FC7" modified="2011-10-19" version="1">MKMLKTLMMIVLLISRCVSAAEEKDETNKDDFYLLCNVTKATLGVWNAVAGKDEVSEEFDSKMSLLGQKIKELFFGEKGNKSGVGYWNMPDTFTGNDPKRSDVCLSSKSLYDMPSASESMASAILCLCMGLPGDDEDLCGSHIVGGENWPYQNPTKSVTNLFVDVWGNLHSDGVMNKCGNPDGGDDMDQQKKNLYTNVEAMKKKLETKKGILGKNDNKCEGKSSCARVTTAPDWQKKLEEIKEITQALVLLEKREKQLKQNEQKTETVPTRKNEPGTTNNPTNAPAHETSVEPTPIPVNSQVPVEILEQKPQKAPQEKKNSDTKPKKEHEKNFVEIHSNRTGKEEDAFQTAEHNDTSSNFITCPKMFPWLALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W753</accession>
    <name>F9W753_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1571</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_38320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000987">
        <property type="protein sequence ID" value="CCD13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38320"/>
    <dbReference type="OMA" id="ERIINEX"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="574"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="1362"/>
            <end position="1389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1392" mass="154602" checksum="A4322697DC9A432D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7I9</accession>
    <name>F9W7I9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_39350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001041">
        <property type="protein sequence ID" value="CCD13156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39350"/>
    <dbReference type="OrthoDB" id="1664673at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394596" evidence="5">
        <location>
            <begin position="24"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="85"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="402" mass="44178" checksum="28FFE54F92269793" modified="2011-10-19" version="1">MGWLLNGLAVFIVTGILVKEWRAQADADVPVKADDNVEAFSLLCRIYNVAKHPPTKHVDTKDYQRIVEEIDTLSVLVSRYERVNTKTKEAKLAQQQLVGVSGEAHKILEEVKNVNPEGEAEKAKEAFNSVIFGEQGKEEDLCHGPLRGMESESRITTCGGNNPEKKGESSGKNLIVDFFCLCAQPNEDDEGVAKVCGVSVGTADCLGWGTKLYQTDEIWREVKKGCEAFGPQSTTSTQDGHSIYREFLDKIAVGGKVKVKNSDTVTKPGMLGTAVSDTGKTNFNCNGKKTVVTRDKVGSGSCVFYGVDKLENNTAWLKQFKTGLEIIDKLNNKTASWQSKLTTLINRARGIYEGAKKASQKEEEDIEEPKAAPLPNQAENETAESTTPSKLHRVLSWVLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7M1</accession>
    <name>F9W7M1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001051">
        <property type="protein sequence ID" value="CCD13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39640"/>
    <dbReference type="OrthoDB" id="1703721at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20786" checksum="8F7C45554ADA60F3" modified="2011-10-19" version="1">MEPIPSCCDAHSPQEWDVTEDTALQVMQLLGKFLDSFLPPLILLDVVGWVFQESSESRIGVAGSVCLPTFLSQKVNEASAFPEFECLPEDLFRLIVLSPSTLTLCAWSAGYLICYLVTCLVAALHRHASACYSRPRVLAGYSDGFIQDGSWSPGQQCNRSTKSPIKKSYDAITHKVPDVFGRIFMQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q6</accession>
    <name>F9W7Q6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001065">
        <property type="protein sequence ID" value="CCD13228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39980"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389974" evidence="1">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="265" mass="28780" checksum="AC8D919B2C2717A2" modified="2011-10-19" version="1">MICARNVWVAVVVIVEAVRGASEVNTGKTDHNSDKHGLLCNVLASTVSLFLSKRGGIQLQKAVRESIFGIGNRGEEDATNLKLPTEYDGQGSRKDLCGSCGDSEHHPGGSIPHDILCLCTVGNGGAPFGGDKYYSLCGLSGEHWGCQKYSAGDHYVGTGQQWECVDKSWNSGWDQPRRHTAWEKVVKPCLEKGKTLSFTDALSNLEAALNGWEHPKWGASHEGCGGNGFGDICVKYSQWCYTSTWWAQLKEGLKQIDLSEPETAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D3</accession>
    <name>F9W8D3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42140"/>
    <dbReference type="OrthoDB" id="1699829at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="25236" checksum="D1055A0148DEBC34" modified="2011-10-19" version="1">MGRSSRAGRVSRCQIKYGKQAKYRHRSRVGSAMAPSVLSGEQKKRKAQLKAPQHTPRHTRATHTSRGAAKLHSRPQAEAFRAITAQRKLNQSKPRQRKVKEKKRSVRHIPLPSTTHITQLQHESEGEYPQRTVTPITEAPLKYCNNNKPPAMIGDSKETKREKRKAWCEAHYKPHAHYHHPCFITATRLLIRTSLIGCIYSNIGKCRCCCHWELHYPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8M6</accession>
    <name>F9W8M6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001186">
        <property type="protein sequence ID" value="CCD13560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43020"/>
    <dbReference type="OrthoDB" id="1285794at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16715" checksum="6BAEB821068E41AB" modified="2011-10-19" version="1" fragment="single">MDSRNGAGSSDVTSLYIGLGPAAHTISEGRLRSTLEEFAKVLAVRIRGRCAFVDVGGMDDAKRLIEELDGKFIGEARMVVQLSRGKERDRDRDWDRERDRRRINDRDRVRDRERPGDRDYDYNRERVSYNLSESRLEVITARPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8W9</accession>
    <name>F9W8W9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_43930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001230">
        <property type="protein sequence ID" value="CCD13655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43930"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389976" evidence="4">
        <location>
            <begin position="18"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="93"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25859" checksum="9B30A066BE054E15" modified="2011-10-19" version="1" fragment="single">MVKCILIFLVTLMGVMGNVADKQYNKVEFKHLCKILRVAEGEPQKIPDELGKFTDVRRVLNSLLRATKTSTATYQKVIRLSSSDNDDADFISYTVKRRLANEKIKHTMGKVNEIFSRIEEELIQARKERTQARNSLVHAIYGAQVGEIPKDQDISSVLENVSRASIFNRWGGELDVDVHEDVPKEPTCGATTGEGAGFTLINDFYCLCVGKDNDKAVCHKGVKGPGTWIPEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W920</accession>
    <name>F9W920_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04660"/>
    <dbReference type="OrthoDB" id="1701332at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21484" checksum="340A9901D1770274" modified="2011-10-19" version="1">MHFVVKQTMSPIPACRDELSPQQWDVAEDTALHVMQLLGKFFDNFLPLRTLFDVVGWIFQESSESHIGVAGSVCLPTFLSQKINEANVFPGFECFPEDLFQLIVPSQSRLTLCAWSAGYLMCELATCLVSPLHGHASVCYGRLRVLAGFSDGFIQVTSRNMVQQCTRSTKSPIAKGYGAITHKAPDVFDRFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Q3</accession>
    <name>F9W9Q3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chloroplast protein-transporting ATPase</fullName>
            <ecNumber evidence="1">7.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_46420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="SecA"/>
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        <property type="entry name" value="SecA_DEAD"/>
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        <property type="entry name" value="SecA_motor_DEAD"/>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD13957.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1373" mass="156283" checksum="248A4179182090AC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
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    </reference>
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            <end position="705"/>
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            <end position="753"/>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD13958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1664" mass="185367" checksum="B0D8FD73AAD55728" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Y7</accession>
    <name>F9W9Y7_TRYCI</name>
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            <taxon>Trypanosomatidae</taxon>
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            <taxon>Nannomonas</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21196" checksum="655AAF7675902C70" modified="2011-10-19" version="1">MQGRELALQFKRQGMCYDEVADVLWCSLCTNSEKLVVLSGSTVEKVLEHCKTRRHLHLMQDVTMKKHHCPVEINGRKILLDHICIYPATMFGRGKMLLDDTLGCVIAVDVCGGVKLVPRHKYTVVEFVLSPSKAPIPECPCYHTERVARSKKCTGDVPTWIRSHNNSIDGETALMKRRRISFGELNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA13</accession>
    <name>F9WA13_TRYCI</name>
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001371">
        <property type="protein sequence ID" value="CCD14068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47360"/>
    <dbReference type="OrthoDB" id="1522976at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394631" evidence="1">
        <location>
            <begin position="18"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="472" mass="50629" checksum="7742E1BB13FE91B8" modified="2011-10-19" version="1">MALFTCFIFLLSSFTDSLHREYSDIMSSGAKPHPGEAFPIHEAQVHPAYDPSMPPPPGGSHEIIPAKVHPAYDPSMPSAPGKSHEIIPAKVHPAYDPLMPPPPGGSQADPSAPGKDHEIHYAKVHPAYDPSMPPPPGGTHEIIPAKVHPAYDPSMPSAPGKSHEIIPAKVHPAYDPSMPPPPGGTHEIIPAKVHPAYDPSMPSAPGKSHEIIPAKVHPAYDPSMPPPPGGTHEIIPAKVHPAYDPSMPSAPGKSHEIIPAKVHPAYDPSMPPPPGGGQALPTDNYQHPLLPGYGQPPHVERSGGLANEPAGEGRNVVNEWKTGLLVAPCRQPCFCLGSCFCPCCCTFMQRKKLLQGDWSRYTCCAGICCEKTCCVIKKCEPCCLCLETCCCFGCALHGNRFMIREHYGLQNDCCDDILMCAGACCGILACCTEKKAVKSIADILFFFTIGCVLAQHEHQMKVCGYPRGHEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA25</accession>
    <name>F9WA25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1924</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001380">
        <property type="protein sequence ID" value="CCD14081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47480"/>
    <dbReference type="OMA" id="RCLENAP"/>
    <dbReference type="OrthoDB" id="903175at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="712" mass="78951" checksum="68D843900FB43876" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA28</accession>
    <name>F9WA28_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1924</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001380">
        <property type="protein sequence ID" value="CCD14084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47510"/>
    <dbReference type="OMA" id="ITETHNW"/>
    <dbReference type="OrthoDB" id="1040311at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="757" mass="82408" checksum="DDF728EF6B2094F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA35</accession>
    <name>F9WA35_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1926</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001382">
        <property type="protein sequence ID" value="CCD14091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47580"/>
    <dbReference type="OrthoDB" id="1711753at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="24377" checksum="495D36AD51DFEDB0" modified="2011-10-19" version="1" fragment="single">MKTEKSEKRASHVARRYGRRKRQKSQYAEHVEAHEVVKERLPASVEAHSSSLQPAFEELAATSSAQCPDVEVVYGCVPTWWVARWYRWYAADPQVCAPPPPTLNHSALRCQHGGTILPMMLLNPNDAFWSKKIVAKHLATVWKRVLANPSAFDGCDDDGDAGYIPPVLLVPLKEFMTLLEKYGGNGSVSHIVESTDLVNQLLEKNFVLLVERNGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW8</accession>
    <name>F9WAW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_50090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001491">
        <property type="protein sequence ID" value="CCD14391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50090"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388925" evidence="5">
        <location>
            <begin position="20"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40117" checksum="987B43ACA6EC5B10" modified="2011-10-19" version="1">MWRYFLLLILAVGYISIEARTSSEAIYRQLCNITNDAVAILRLNGKRSALREAIYGRYGRALFNDNGIVTIPARCGDAPSGRGVLCNYFKGGRQGDGCLAESLLGTLMCVCAPGARDDKKLCGTEPWEFDGAWWGGFGSNKERDSLFKDVWKKVISKCLVGNKHHSSTLEKLKSLEQTLKAIRGTLRSRAWGGTNYFYLGQSAVTSCGGGIHDGEGICVAYRGGSGETKDSVNIPWITEIEKATNELIEIVPKQPIESQAEADSPSAEKEADLPIPAEGNEQLNENESLKRGNPTEKFVTQTVSAEYEPQFNKSKRIPKLAKPEEKGNPHKYNIIDIPHLATNPDEDGSILICKKWLLLSILFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB16</accession>
    <name>F9WB16_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001517">
        <property type="protein sequence ID" value="CCD14444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50580"/>
    <dbReference type="OrthoDB" id="1732857at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390086" evidence="1">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18513" checksum="0FCCD0B9EDA95A62" modified="2011-10-19" version="1">MVVKARMLLRLLTGVLMCSVEALGSYYPKAIPTEAGGSICSLSRKLKDVAPWTQEKIAALRKTRDKYGSKLLDWQLHFHESPEYGVNDSILYRIRTVIETVNKEIKTLPAKAIRSGALAAASAGSSENSSQSLRMHKKTALLAKSTTVYMVEATQLKEGICLSASQPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB86</accession>
    <name>F9WB86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_51250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001546">
        <property type="protein sequence ID" value="CCD14517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51250"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388932" evidence="4">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="99"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="425" mass="46153" checksum="376DA8276FA2D9B8" modified="2011-10-19" version="1">MACFMKAIAVVIVVGSIVRGQKELEIDKDENIEAFALLCRIYNVAKNPPINYIDLQEAANIVNEIDALNTSLVEPKLHNETEQMGNGGEAMISPAAMREAAVAQISLTQITQKAQKILEDIKRINVSKEIGKAKAEFNKVIFGDDGNESDLDHGALNGIGDRATACGNTGLSSEGTSAGKNLVVDFFCLCVQRPDGEGANQVCGFYVGSNNKNGQLGWSEAGPSGSSTMWASIKGGCGKHMQQHPKSTAEARHILDTFLKHLKTGGVYRWGDSSQKTVKGSGRKEGMLGTGVGKENNGSDVLCNGRKGGKSGESPGGICVYYGPDKWEDDIDWMKQFNATLTTVDAANDQTATVQRSIQKLQMLLHRAEEIYETTKVISEIQKQEGHTALQNVSGNLTAYNTTRTRSYSYSTNPYFIPRWLLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBD7</accession>
    <name>F9WBD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 2092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_51730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001566">
        <property type="protein sequence ID" value="CCD14569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51730"/>
    <dbReference type="OrthoDB" id="1490344at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390100" evidence="8">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="406" mass="44539" checksum="3BC4EEA481574625" modified="2011-10-19" version="1">MIVALVMLLVVSQRLDATPGAAVSEAAGKLVCTAAFALERVEQYATLKMNQSQRIITSLKLAHNNIKEALVGGRYKDNCTSLISLMNHADKLSSDFESLIPELGRLGLLASSRAALAAGRLREFITAFYHSREGRNRCITLTRKTKKSVGEFTIHRCVSTARDEESQDSPTSTGYNFVKKVTAAVEDLFTLEEDISMTMDNGCNLTRMNALSTGTEGSEDLPEPPDGAKWAGGLLQITKYGPKWVSDIEKVPVLYDAKVKLDAFEKMVVYINDMFSNFVGVLWTDAPSLMKSSEMESLIFYVSLRTFMAPPRGFSSNEKELSILREKYCNNKDAALRDSNISNASLLNDEPYVSPRDSVLVTPPSRSATVFGDETMGVDYNIVSGDVKAIGTAVFALSVVFLLTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBE2</accession>
    <name>F9WBE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001566">
        <property type="protein sequence ID" value="CCD14574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51780"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="357" mass="38850" checksum="6BE01F3B5B6E87EB" modified="2011-10-19" version="1">MHMSQPIGERGRGVAGTTVGTLVTQPASQERQFMGGGGGGRGAGEDTMLETIMAAIAELTLDVKTVKADINSVKADINSVKADINSVKADINSVKADINSVKADINSVSERVDELGEKFEAQNNGGVKVLDGVYDSVMNAEWSHVVVNCAEHDEKWLGMDVSDAKSEGQPQLWSGSQAHAPYDPEEPWEGDEVPGVSGKLVMVTLKSKKGWPYMPFDVVEGPMGPVETLTGYDGRHDAYIRKENFLVWHTVKEMLDKWLENKGIVRPFIVVGTPGIGKSFGTGSLLLYQLLHHPSDKLKVVAYFVRGEAYIFHKEGRRVVHYEEEKNAVKEINGMARNGIKGYAIYDICGENGGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBF6</accession>
    <name>F9WBF6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001574">
        <property type="protein sequence ID" value="CCD14588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51920"/>
    <dbReference type="OMA" id="ACTISTY"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="512" mass="59179" checksum="9CEFE90BF29FD659" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC37</accession>
    <name>F9WC37_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001663">
        <property type="protein sequence ID" value="CCD14828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54070"/>
    <dbReference type="OrthoDB" id="1664326at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="45307" checksum="21E4E7A2B9E712CD" modified="2011-10-19" version="1">MNGIRKCLGEKFPSGKQGVFLWWVLSTMSALFHNTKEEARTFSLMAVLKSGSLPPLTVLPPQDFLAVGPEDCLGYPPDLTVKTPLHTLPFVQSVDPDVIQVLAVSHHKILEGLHLGRYGLQHSSTRFLIMYAPGVFFKEFCNTPCRVCSVFKLEAPLFGHELGKRQDLSVQTSRLKHLSDPRRPRATQWSPWGNTPIQTGSITDCAVAVAAGGVQVLVAFGVSAAREAQGEGLDKRRRGLVYSALNGVLQEESGEFFHPGMILQFRQLPQRCDLAPGQIPNGCAHAHPQPGYQAVELLNHFFQHGCFLHTAQGAGVSPQGQTRHSLFKNPVVWLEKVEQVQVLWVLHTFEKHVPKHTLHRTQYLLLGTFHLLGMGSGLVGLFSNTSISGLVRSSLCDLDRPSFHGGPFPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE7</accession>
    <name>F9WCE7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_55080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001708">
        <property type="protein sequence ID" value="CCD14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55080"/>
    <dbReference type="OMA" id="CILANIC"/>
    <dbReference type="OrthoDB" id="1507385at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="PTHR13256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34847" checksum="74BA91A66B0FA21D" modified="2011-10-19" version="1">MNNEGVLIVGRRLRLVPYLRKHVPRYHQWMSEAEMLECTASDPLTLQEEYDNQREWLYSEDKLTFIVLAPLQLLGGDEKNGKNADMHGGGESCDTTQLQYSERVNDGRNRPWETISDMGLCDISGEPVSEETISNGEAYIMVGDCNLFILPDAGEDIAADATVGIISTNIPIDGKNGVNGGNMESGGPSMTTEEGGRCFEVEVMIAERAFRRLGVGEEAVRLLMSYALINLGATRFVAKIRADNTPSIRLFTKKLGFTLLKEVPVFGELHYVKHFNEFMVNEWRDLAGYAAEVYNAAAEQKFCGSCPLLQNSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCH5</accession>
    <name>F9WCH5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001724">
        <property type="protein sequence ID" value="CCD14968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55360"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16650" checksum="F64D0871751DA646" modified="2011-10-19" version="1">MQPGQQIICTNAVNNETHFQCISQHPNTPAPCRGQKPQCGQQLLHAFGLHHVPRVPGCAWCRAVVVTLACGNTRGNCTSAFYFIPSSCSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCSTVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ8</accession>
    <name>F9WCQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_56190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56190"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394878" evidence="6">
        <location>
            <begin position="27"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="369" mass="41023" checksum="B9D47225B457BBF2" modified="2011-10-19" version="1">MYSDMRNTFLLLFVSCLIFTIEVSLCQDNTEYKLLFDIFRHAEWVAKNSVDSEMLNEAVYGESSKAQFDGQGNIKPLGFRCVGQLTGRALVCSSKSGGRGGDGCFSGSLVGTILCACTPGNRDGAVQNLCGVNIGEYNDMWYGRWVSFNQELNQKKSLFKKVLEKVRENYAHEGENNQDFTTAVRKLKEALDKFRNEIKEKRKVDNSYFIGGSGKYDCSGNNLESVCVAYQYKNGVVDIPWADKIEKATPKLKELKKSLESGKKVTSVQVANRTAGISREPVIRSATNVERVTQDEDAPHETSDQNEDKGLNEENNVIQGNYNGASKKIKKRSSPNTNINEIPHLASDTNEDGSLLTSPKWLLLAASFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCU0</accession>
    <name>F9WCU0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001762">
        <property type="protein sequence ID" value="CCD15088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56510"/>
    <dbReference type="OrthoDB" id="1717921at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19501" checksum="D42A3C6F00ED6303" modified="2011-10-19" version="1">MYAQVVVSKELLSKCLEETLRTQPIIVALTANGVAFSLLVDDVLVSDSILDRQVIFITVRGVFMGGCFDVTVPAVQPDNTVDEAKRICEMLVPRIIEQSDTQLWTLHHMFVGSVDSSSPASPIRGDAGVKSEGSVQKTPSVEICAPLLPKETISSGCEGGFQESWADREKIMLDGNFWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCX8</accession>
    <name>F9WCX8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001784">
        <property type="protein sequence ID" value="CCD15126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56860"/>
    <dbReference type="OrthoDB" id="1701331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21732" checksum="51A0831DA52F13FD" modified="2011-10-19" version="1">MSTETHKSTSAHGEGYLTHSPCYRCPRHQQPPLLSARTFHLLLYPETEWMLDLCAAVMARAWQTPWCDVLSWLRVKQGCAVSLFEGFVCLSIRLGNKFLTFCFHLGGMLFDRGPERERWAVRSAPALTQPEKQKQFCIIAFNLMCKQETLTLIILDFRPAHNPGQDYLVEGIAPLYPGDHTPVRALEIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCZ9</accession>
    <name>F9WCZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001797">
        <property type="protein sequence ID" value="CCD15147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57070"/>
    <dbReference type="OrthoDB" id="554921at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="624" mass="69591" checksum="28B17E4139184F3A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD20</accession>
    <name>F9WD20_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001807">
        <property type="protein sequence ID" value="CCD15168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57190"/>
    <dbReference type="OMA" id="ITERCRF"/>
    <dbReference type="OrthoDB" id="131285at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="559" mass="64771" checksum="51AC6D714959CE22" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD24</accession>
    <name>F9WD24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 231</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001810">
        <property type="protein sequence ID" value="CCD15172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05880"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="318"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="636" mass="70602" checksum="CC5C37EA0CE29DBF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD51</accession>
    <name>F9WD51_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001820">
        <property type="protein sequence ID" value="CCD15202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13980" checksum="EF53023759C7E5CD" modified="2011-10-19" version="1">MEVLSEDTAPAHKSVRVKGPLFILLRKEIHTVFALQNSPHPKHLRRKPFFFLTPLLTRKHIPKPRIPKTQSYTEIAHAPRPRKKKSHRSPNLTEAEARAVAHPTGSVSGRYTPAPPYTACGGGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD60</accession>
    <name>F9WD60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001825">
        <property type="protein sequence ID" value="CCD15211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57550"/>
    <dbReference type="OrthoDB" id="17210at5690"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec3_C" evidence="6">
        <location>
            <begin position="198"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="45654" checksum="CD75FC9AF4C7589E" modified="2011-10-19" version="1">MAANWDDELQQLIQLTFRQRHEEMLACKAVVITGRSKRFKTPKPRFLVLCRPFSAAGTTSSTSNSTLNVVQVGPERVVNVKLVFSVARLVDMGQEGSLDAAFNFGSGGMLSVKFESYIQRQMFIAAVRSVHCDVQLLAPAVGTDRKGVHTLLLDEMGIVKDNNIVTQVMTQRQVKRSALTTEDEQQLQDFIGPHSFDDIRATENLLSTRQKKAELLYINDLVSSSNEWEGMRDGICSIVREVEELEEHIARYSRRILSQKDQLQRIENQYNMLQRKQENLEKLREHMHMFNGQLDLPQHVQNLLQRLERKSEEDFMLYLSDDNNARLVSDAVNTITSLLQDTRPEVDYHIAAVMERRAAFTAQRRMVVQRFRAYVLSTIKQYEDIYLSDTQRFSTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC9</accession>
    <name>F9WDC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_58130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001857">
        <property type="protein sequence ID" value="CCD15282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58130"/>
    <dbReference type="OMA" id="YTHAECK"/>
    <dbReference type="OrthoDB" id="1246075at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005779">
        <property type="term" value="C:integral component of peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15794" checksum="105EB13CCB749E58" modified="2011-10-19" version="1" fragment="single">MSAKTHAYLSDTWNRDKVMAIVQFLPMALEGPVRTVGCDSLAQSLGNLSRMGDAYRAITRLSFLANALSRPTLEGLSKPVGDSITWRIDQLSHAFHIGFCLSENTAVLSGHGVLQKGLGRMGGVAVLCWMYTLVLGIVRQVYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDV2</accession>
    <name>F9WDV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_59760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001916">
        <property type="protein sequence ID" value="CCD15456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59760"/>
    <dbReference type="OrthoDB" id="1664325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390194" evidence="4">
        <location>
            <begin position="36"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="109"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="409" mass="46639" checksum="87C769B6089DB87B" modified="2011-10-19" version="1">MRLYIRRGGHLSSMHVGIVVKLLLFVAFTLPNSGASETVRNKAEFSALCWFLRISNTAEWALTTDHFKHLAPESLLKRQQLVEWLQQDGNGTLEALEDQLDVAFWYLNETERHAARRMYEAFEKRKSNISELQIKIQEKANQSRQILENVSSLFRAVRYGDSRKCETSEEWIDNVYTKAAQRNRTCNMKNSDPRQPRAGSSLVNDLLCLCAVGDIDGGDHNEMICGIELDPNSSWTDASGFTPYTAGQEWNRIWQGCMKLQDKADLTVENLQGAIDHFESLLGTNARDVDPENDLHEFQWVLGYAGTGWDVTSLSVCSASSYYPEDALGQCVNYANETGDERGNIAWLQTLQEILAQLRTYEDIHREVEYLEREVDNIGKDMEEEFELSGLNYQEPSKPKSLLFLLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDV5</accession>
    <name>F9WDV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_59800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001916">
        <property type="protein sequence ID" value="CCD15460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59800"/>
    <dbReference type="OMA" id="NCITEME"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="114"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="465" mass="53414" checksum="36D6348E53430A9F" modified="2011-10-19" version="1">MLIIHCSLTRDFFFLVVHTKGSKAMVTHVIKAFLLYIAVVLHGVTQLQSHNKREFRVMCKLLSFHEKGIPPPQFENVEKENAIIEEMEFLERATGPDVSKFENSVWKMKKFLKEHPPPEGEEARKVANEEIRRLLQKAEEVREKSNQNRNSAIAPWENAQLKVLQAVYGEQATNLTKYLGTQVNFTSNTGDIFEDNDTANYSCGGGEGTDFNKGKTVGKTLINDIFCLCVGRCNLGNPCHDDIGSPYKAVYKTREKGINCSKDTSPGAWTQIKYKTGSKSALSFTESWEAIKKSCDDVLKLEKFNIEMNATLAEFEKLLHGDKESDRSRKILGYEFNHTKLSYKCIGNATQLGDKDNTLGYRVQKEHQTCVDYTYTLKNNNDIPWRKKIKEAMNCITEMETIVAEEQTYLAELIQLKNKAWMAYNKEKDDEFYEIENYDYNKEELADFLKTHFLHYALIYLISVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDZ7</accession>
    <name>F9WDZ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001933">
        <property type="protein sequence ID" value="CCD15502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06240"/>
    <dbReference type="OrthoDB" id="1764332at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390234" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="18868" checksum="C7E4EC5FDD67568F" modified="2011-10-19" version="1">MRARTSALLISALSSISALFPHVPASFAKDASLLTGGLLQWGPHVACLVVPFLDLPHLTHPIPAAHTLQFPLEHGKPHVPATLSSPPLLSAAASSAASSAAMHGGSSGSVAPPCLPIRCRSLLAHALSSHLHTRHANSPLAFGPRPLEDRGCPSPPPPPQLTFLSALGVSLATAISTTGTPQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE18</accession>
    <name>F9WE18_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_60300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001939">
        <property type="protein sequence ID" value="CCD15524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60300"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="OrthoDB" id="257116at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389023" description="H(+)-exporting diphosphatase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="648"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="700"/>
            <end position="719"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD15524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="821" mass="85340" checksum="DF96FEEE448DA5AB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE87</accession>
    <name>F9WE87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TCIL3000_0_60790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15094" checksum="F0BD3A19F6E17562" modified="2011-10-19" version="1">MNPTTSRKAFFNGRPLSAVGIVGTRPASGIPRVHLPLGELTVDESGRGLPPSCHGRCDGDFPCALPSLGAGRLKPKESRHEKSLATHTDVFARAFVEREIPLRSARFAVFNFTGTTNFLRKDRAIPSASRWGRASPAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEH1</accession>
    <name>F9WEH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 267</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_06950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002012">
        <property type="protein sequence ID" value="CCD15681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06950"/>
    <dbReference type="OMA" id="MASKECY"/>
    <dbReference type="OrthoDB" id="659174at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004324">
        <property type="entry name" value="FBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="PTHR31585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00788">
        <property type="entry name" value="fbt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="639" mass="70057" checksum="721EE4AB1C43AC3E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK3</accession>
    <name>F9WEK3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinase</fullName>
            <ecNumber evidence="3">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_07270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01002027">
        <property type="protein sequence ID" value="CCD15714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07270"/>
    <dbReference type="OMA" id="DFARSTW"/>
    <dbReference type="OrthoDB" id="902814at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="PTHR12400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38318" checksum="20AC1873630EC961" modified="2011-10-19" version="1">MLNECWVTGSGGGSDRRVNAEPIVVSGHRDDIERGLPTAIGIPTIVKRTTAWEALMYLEMLISANEAYGELKHFTPQLVAVRPPAHLGFDDWIYVQEPASQGLLVALHEQLRQLGRSCECGGGVMDAKLWKLSLVDVTAAARRPCVIDVKIGAVRYSPYTLPGKLEAIYKKELGRTQLIRITGAHHEIYSPTSVSSRLMVVEQFTKEMGYALLSDEANSRALRLFFSSRASMILSDGGEVSDDNDNGCVRARLYHCCSRVRQLVDFFKSELGQKLLENTAFVSTSLLLVYDAAENTCEAAAAARVGVYLIDFARSGDRRLNFSEDVIRFVQGLEEVLRLLLFKDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEV0</accession>
    <name>F9WEV0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 316</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002066">
        <property type="protein sequence ID" value="CCD15816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08170"/>
    <dbReference type="OMA" id="RKSPWAL"/>
    <dbReference type="OrthoDB" id="1230424at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="838"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1061" mass="114581" checksum="130E6A97B6A3CE2D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEX0</accession>
    <name>F9WEX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002072">
        <property type="protein sequence ID" value="CCD15836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15617" checksum="122EF4E6B93B0431" modified="2011-10-19" version="1">MYLIECSTHFAHKPFSSFFFIHIPFPSYCRCRSCVVLFHGRLPLGGTEGKVSRNLPFGISHLLLHYYHRSFPFAVFVFIWLCFPCLLILLYLSSRCLVLVRIIYCLYIYISTMHTFIHIPLVSFSLCLFAYCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ3</accession>
    <name>F9WEZ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002081">
        <property type="protein sequence ID" value="CCD15859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08560"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="23162" checksum="F9540218B29F0AF5" modified="2011-10-19" version="1" fragment="single">MVLLCLLKETHQASAECAALNIGAYQHVGQARTPHGGGVSILVRDGVGVDVGVLEKTVPERATVTLRSPAHVNLIIASAYLPRNTDVTSEALGTVLGANGAMVIGADVNSHHVLWDPLRPSDDKGECPLHWCLQNDMRVANTGLATRRQLGTAALLSPDITLCRDCEISNWKSALSPDTDHHWVSFDVFVGASLDVMAPSKPVRALYSWNKARWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF03</accession>
    <name>F9WF03_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002086">
        <property type="protein sequence ID" value="CCD15869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13453" checksum="7CAEDCB57C7B1FC2" modified="2011-10-19" version="1" fragment="single">MKHGPLQNANTEYNTYNQSNNTNNKLFKQDFEAWRTISFHYPLSFSSFLPPLLHPTSIINFLSTLAGIKSAAPIYNEVHCHIDIPIGHSQGFQTEFFVGKSHIFHDLKLPCPAVCIVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF26</accession>
    <name>F9WF26_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002094">
        <property type="protein sequence ID" value="CCD15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16306" checksum="0BAE1E2163056842" modified="2011-10-19" version="1">MNPSHTTRGKEGSKRENKKKHQHMTRDVITVITNSCIVATRNIVQKKQTIKASNESRKETRSSQIWHTFPRFSKSAAINPYRIPPVKNKCTATNLSTTAAPLRDASRVRGKEREERKEKKKKVGWYGSTAAAEGPFGTPHLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF88</accession>
    <name>F9WF88_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002115">
        <property type="protein sequence ID" value="CCD15956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09420"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18250" checksum="27D7DCE9EF9D7197" modified="2011-10-19" version="1">MQRGRVPTLLSEFASDGPKRELVTGCTYKPLIPNFPLVDGSFVVEGVGPNTIVLLQVTKAKEHHTKRTTVRKFRQCMGKAFERREKVEKACGWETMNVQHVDSGSIKKRWKCSSSGDGVNDTDLALWGRTNQYHVTLNRDIANKFMGYKDDTFEPITNDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFE6</accession>
    <name>F9WFE6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002134">
        <property type="protein sequence ID" value="CCD16014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09850"/>
    <dbReference type="OrthoDB" id="1685901at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390257" evidence="1">
        <location>
            <begin position="31"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="251" mass="27406" checksum="B2F5FD0DB41AD2EF" modified="2011-10-19" version="1">MGTPQHVSVMAMLPPLWLMCVLWGFATATGEDCKDNVTVHVYNLLYSKKIPPSIYVPLIAGFNASVHAGRKKLPAGVNLNVLHPPSLELGVTPEWLSGNVKRLNERDIPIVVGPVGDLPLLAFLPVLNEHNAVAFSPFTGSSTTRVWNKNLYFITASPTAELLALLRYAVTQLRLERLGFMYLQGVSFGDEEYRLTVNALSNIGRELCGLFTVKSSIAGAAPDAEFNAAWEQFAETRPQGVIVFAPSIKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFF6</accession>
    <name>F9WFF6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002139">
        <property type="protein sequence ID" value="CCD16024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09950"/>
    <dbReference type="OMA" id="GWVENAP"/>
    <dbReference type="OrthoDB" id="841770at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="206"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="494" mass="51381" checksum="E7A80A6BF81E1575" modified="2011-10-19" version="1">MLFHTSQCGFNNVPVVSFAPFQAPMGSPPPPQLLGPQVTTFYADTIQTWQGPVQIGKFNSSPPASQGSASSTPPSLSSSGHSAHNSNAGNLNGFHSPSFGNSVLIASGNNMQHYHQQHNRNFSGISGGGSIPSSSNISPMPPVTMSPCTWNFSVPPASQPSQPIYVMLPPTPTPGRAGPAGAALPPTPTAEVPRRSNGMMYELGEWYEGFVKRYNPTRGFGFLTATHHLQIIPPNAGRCTGPRHDTEGENTEQPAPQSQPYIMKTPVSVGDVFVHQSYIRMEGFRALTAGDVVAFRVGKLSGKDAKQAVSVQVLGTTNATNGAAKDGVKAKASQEAGESDISELSTTQARHDSAANEDGTTGRGGPNLADGAGESASISMEMLFAQISGQSAVNDNTPVPSTFCEPASSLNPSTNEPRNDGGGDGGHGSYCGWTGDGVSGSGDFPLGNLLGACVPDLRATDFNSGVNLHMQTAGWGMTSSSHGTPRPFGGLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP0</accession>
    <name>F9WFP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 411</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_10740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingomyelin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002171">
        <property type="protein sequence ID" value="CCD16117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10740"/>
    <dbReference type="OrthoDB" id="599210at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025749">
        <property type="entry name" value="Sphingomyelin_synth-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="PTHR21290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14360">
        <property type="entry name" value="PAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PAP2_C" evidence="10">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="31162" checksum="EB00108E082BA432" modified="2011-10-19" version="1" fragment="single">MFVGLWEIVSSNTHSPCTCCYEYPHWCLSPATHPLLPIHTLGLEATVMSERQATRCSNHLRGRWRTPLPLWTQLMRFLLVLLISTFIIAVALVVSHERMPDPKVTKPLPDLGFEIFAKVPKLSLLADLSIGCLSVLSAFTSLKLYLLHRQAMGLGEVEPSFKIPVLNRLLFSVWMCKENCSLELRNVHLIAWIRFVTSYSLLLLFRSVVIVTTELPTPVDKCQDPPKITNPLKNIILTVITAGGGSIHCGDLMFSGHTVILTLHLMFQWVYGRWCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP5</accession>
    <name>F9WFP5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002174">
        <property type="protein sequence ID" value="CCD16122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01360"/>
    <dbReference type="OrthoDB" id="1690130at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="25400" checksum="BBC89AEDC1F5540C" modified="2011-10-19" version="1">MQKNFSTIRKTCPQCCLPYHHSFFSPILAFSISIPMSLYTFHSPRTIPWSMEKDVVEVLLDGVTSPDHVNLYWLLRPVLACLTVDLVCFTLRDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPCQGVVLVEAAPAFIQVPYSTMGYLVPIPISPQSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ0</accession>
    <name>F9WFQ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 415</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002176">
        <property type="protein sequence ID" value="CCD16127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10780"/>
    <dbReference type="OMA" id="MKHRMDQ"/>
    <dbReference type="OrthoDB" id="127946at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="2">
        <location>
            <begin position="657"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="914" mass="104452" checksum="5DF81E4089306931" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX8</accession>
    <name>F9WFX8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 435</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002198">
        <property type="protein sequence ID" value="CCD16208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11560"/>
    <dbReference type="OMA" id="HITERIF"/>
    <dbReference type="OrthoDB" id="816723at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="PTHR13452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39521" checksum="ABE70EEAA26E5A11" modified="2011-10-19" version="1">MPAVRTHRQNVGRQRHHKSRAGQILVPHGRVSGLLWTVNPRQEPKALRELQLFLQPLIADLEKAQGGVGDGATGCDAGADGGPSPSTSSLLSAELAACTTTRGGDRNAPEGCREGKLYRKRSRPEEKADSNSHRWLAALETYCKGYLMVSVPFPPAPGEGSPRCKTPELEEDSATERGTCDGVGESGKGERNDLADSAHLVVHNPMVRTVVERIFADITEGRRPVLRHCFRLMPCELTCCPTLPEMRQGLECLTKEHFPPSSAEIQQLHKIGLSFAVKNNTNVEAKKSYLQAALEATFPTNRFVVIPMGRLQGYVGDVEAVFSVIVVHSTCVMGVQWHFSSREKFNLHALCAKHLELSTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX9</accession>
    <name>F9WFX9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002198">
        <property type="protein sequence ID" value="CCD16209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15143" checksum="199B2F90C456C66A" modified="2011-10-19" version="1">MLDQLVRATRLRIQLGRGSGSRVVTEVSRRSGPRVTRHQSWVVSSLASGSVKYFVSGTSSVSRSASTGVLVSASLRFPLNRRPRSLWNHLIYAVFPHGVSMGMRHASHCGSLGARLTFDRPLFPPPHSAAKGHRFAPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF4</accession>
    <name>F9WGF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_13140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002266">
        <property type="protein sequence ID" value="CCD16390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13140"/>
    <dbReference type="OrthoDB" id="1672023at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395024" evidence="10">
        <location>
            <begin position="27"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD16390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="389" mass="42138" checksum="F082F0DA796858DC" modified="2011-10-19" version="1">MLMEPRSTWWLFLSVVMLLPPDSALCNGPKAIPTKAGEAICTLSKTLKDVTPWVTQQVENGAAKITHLEMKLLDWQSKFFQSKSKGSGSEACKITGLLFRQVRKEIDKTRKEVERLEKEASKAAAFAANSAGRLDEFITVFANARNGSSTGFCLGDSDAAKPEALRDCFSKTDFGEESLVDIGERASGKEPNLDSTIEGIKYSKLSSHFTTGSGGGCNLIKGASGGILGKTNLEKSLWWGGGILTIGKAFDGVFNRENFIAGEISNATNSKAFWTADPAQQIVHLKNASDAFKAFKAVQEAIQDKVKSIEDKIQSCMGGQEPGENNTEQNATEQTQTSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPTTQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGV0</accession>
    <name>F9WGV0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 554</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002331">
        <property type="protein sequence ID" value="CCD16538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14520"/>
    <dbReference type="OrthoDB" id="1738971at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="211" mass="23505" checksum="E03A595A35B99363" modified="2011-10-19" version="1">MRTVKRVRFFFFFFFSFDFTSLNGFFSLAAVELRQRALAHSGVRGLPCLRRCVSPPRSGKGRERCWRAGRLLDVLLSLYMHKQVGTWGRGRLCAASRVLPRLALVVVGVSVSVAGAVRKSGEALRGASKWMRECAMCGTSQWVCCRLLCSLLLLSLFFFPFFLPVSSPGASCVLLCFPQFLLLPLCLFLPTCWPATECAVCAQQWSCANVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW1</accession>
    <name>F9WGW1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 560</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002337">
        <property type="protein sequence ID" value="CCD16549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14630"/>
    <dbReference type="OrthoDB" id="669042at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="34351" checksum="6ECAF681D52E5B8A" modified="2011-10-19" version="1">MDRNLLSGGSGGYIRDGVTGSRGKTEVESAEIYGNNQRGVAVCAEAFKEQLRMGLRSINEEEYYLVRYRDYSAWAVQHYACVAKRDSYLWKKYVEQCFAVHVGKEPGELIPITEAQFLFGVELLQRQLLEYVGMCDSLDINYCALSKDQFRSLGVILGDGMRPVGVEGEELQRRREEEAEAARRSTNPHADAYVPPSMWDWTPGAIKKRIRHQLQLQYSRIGRFVVRVVMFGAVTYIVWSYVQPLLPQGDGTGGGNRRQRRGRGPRGQYDAYEGDGASFVPRSLFRSVLLGPKEVFDYILGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW6</accession>
    <name>F9WGW6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_14680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002339">
        <property type="protein sequence ID" value="CCD16554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14680"/>
    <dbReference type="OMA" id="WHNETEE"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="20"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="100"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="46777" checksum="D14C2246FF68B358" modified="2011-10-19" version="1">MACFVEAIVVAIVVGSIVRGHKELEIDKDENIEPFALLCRIYNVAKNPPINYVDLHEAANIVNEIDALNNSLVEPKWHNETEEMGNGGEAMISPGAMREAAVAQLSLNQITQKAHTILEEIKRINVTESIDNVKTEFNKVIFGENGDESELDQSALSGVNGRVDACGKPGLPSEGLRAGKNLVVDFFCLCAQRPDGVGANQVCGFYVGSNRESGQLGWNETGGPSGSSTMWASIKGGCGKHMEQHPESSAEARHILDQFLKHLETGGVYRWGEKSSRNIIVLGSGRKEGMLGTSVGTKNNGGKDILCDGRKGGKSGESPGGICVYYGQASGSWEEKIDWLKQFKTALASVDYANNQTATVQRSLQKLQMLQNRAEEIYETTKVISEVQKPVVLASLQNAGGNITAYNATRTRSYSYRPNHYLIPAMALLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC0</accession>
    <name>F9WHC0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_16180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16180"/>
    <dbReference type="OrthoDB" id="1678567at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390389" evidence="10">
        <location>
            <begin position="23"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="28"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD16712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="42311" checksum="E7465CF2F156EE7D" modified="2011-10-19" version="1">MELRSKCWWLVGVFMAWSPVFGEGDTPTKAIPTKAGAAICTLSKTLKDVTPWVTQQVENGAAKITHLEMKLLEWQSKFIQSKSKGSGSETCKITGLLFRQVRKEIDKTRKEVEKLEKEASKAAAFAANSAGRLDEFITVFANARNESGDGFCIGKDKAATPEELKDCFSKTDFGEESLVDIGESASVQEPNLDTKIDGIKHSKLSSHFTTGSGGGCNLIKGASGGILKSKSLENSLWWGGGILTIGTGFQGESSSTFGAGEIPTATKDKATWTADPAQNIVHLKNASDAFKAFKAVQQTIQAKVRSIEDKIQECMEGQEPGANNTDQNATEPTTTAEQTPTSPTCFDNVAKIAADLKEKLALLARYQKVKGWIPPSSASHPITQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD5</accession>
    <name>F9WHD5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_16330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002415">
        <property type="protein sequence ID" value="CCD16727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16330"/>
    <dbReference type="OrthoDB" id="1675026at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389139" evidence="6">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="40"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38142" checksum="D113B791B1B0DE47" modified="2011-10-19" version="1">MKEMLKAVKVTMVVGVLVIGIQADVAKQLESTSSFDLLCNVMQATTGVYSALGNSQLDVVEEKVNELGLIINKVFFGSNWSGSGGGIWSLPENFTAKTPKRSAVCGSNSDSERMPSASDSMASAFLCLCVPTIKSGKDMCELHYDGNEKWSEDLNQNVKNVFRKVWDEGFDGLVIKKCDVRDSSIGDLEQERQNLEENLTKIEGELKNKAGILSEEGKECEGKFPCANVTLEPAWLKLLRTIKEITSITKPPEITQEPETEMSNFLPATQAETVYPPDPASSYVPVQAPKHETREAPQPQSQPKPNEKHHQPPPKQVEDHQVPELNETSSSLINSPNWPLWAALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHG0</accession>
    <name>F9WHG0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002431">
        <property type="protein sequence ID" value="CCD16753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01770"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389144" evidence="5">
        <location>
            <begin position="22"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="101"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="450" mass="50133" checksum="89A49D98C69C109F" modified="2011-10-19" version="1">MVRCAGLGLAAYSACIAVTLGALGTAGTRPHNEEEFKVLCRVLRVAEGTPAPVPDNSSIELKAVQQARLLARYTDVNEEQYDLVVRQSKQDFSKEKLSAEDEDFLKYTVGRRIAHEKIVIIVRKMERIYKRIREKMEKATKARENAVKLLAHSIYGNTVDYLPTEENITKLLSHIDKGSVFNDPNGVVAFDGNYYAGSSCGAIVHEAGRTLINDFYCLCVGIVKNNSPCHTDIKGTLDNCNMCCSDASKREEVGNAKCTSGNWTWLNADGDAKKDFSEGWPVLRSKCPQETENASLTADAIRVALEGFRHMLGKQYNDGDSKFPTTMTVKNFVLGKMAKISYIMYPQDEGGCVGEENQTCVNYWNALIKGNGIEWENKLLKAMNEVETFTVEVEQAENLSMVLFSLKKEAERIYGKEIVGNVSWEFDGITQALRARDLIAYTTIACFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHV8</accession>
    <name>F9WHV8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_17860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002490">
        <property type="protein sequence ID" value="CCD16903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17860"/>
    <dbReference type="OMA" id="SIRGHED"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="7">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48150" checksum="2B9DDF3FD36556DD" modified="2011-10-19" version="1">MPRSEMARTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRMFKQSMERAKEEAAANPYATFGVTQFSDMSPEEFRATYLNGAKYYAAALKRPRKVVNVSTGKAPPAIDWRKKGAVTPVKDQGKCGSCWAFSAIGNIEGQWKVAGHELTSLSEQMLVSCDNMDYGCRGGFLDRALKWIVSSNKGNVFTEESYPYDSTDGDVPPCNKSGKVVGAKISGLINLPKDENAIAEWLAKNGPIAIAVDASSFLDYTGGVLTSCSSDALNHGVLLVGYDDSSKPPYWIIKNSWGKKWGEEGYIRVEKGTNQCLMKEYARSAVVSGPPPPPPTPTFTQELCEGAECQSKCTKATFPTGKCVQLSGAGSVIASCGSNNLTQIVYPLSSSCSGFSVPLTVPLDKCLPIVVGSVMYECSAKAPTESARLVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHY8</accession>
    <name>F9WHY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002500">
        <property type="protein sequence ID" value="CCD16933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16875" checksum="85F0B0124FC90E54" modified="2011-10-19" version="1">MYGFPMGFGCRAFRPFCEYLVQRAVPRLLRHRRGRPPHETRPLRDLHRLQTPRVGMAGRVTWMTLRKMRSLSLVEAASLGHLRVRRTHRCGLSILTPTDMVHLPIDILQHISKALLQGYLLLSQFAMVHRTNVPCILAGAASYVADVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI31</accession>
    <name>F9WI31_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 72</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002520">
        <property type="protein sequence ID" value="CCD16976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02000"/>
    <dbReference type="OrthoDB" id="1683185at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390414" evidence="1">
        <location>
            <begin position="33"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="261" mass="28651" checksum="8AB7EE9BDD07CB9C" modified="2011-10-19" version="1">MAVKTRAETPRGSKTLVVLLIILLADSAPLEAQEHVVVNIKYYNAYNNGPFNTPNGYMVSYDIADRYCTDIGGVLAAAQTPSAHERMHRSARKAMGGGAAFAYLGGDASHSASSALEPQTRCVAGSPASSLNCIYRWNKGLFATASSDGKGCAFWRGSYASARGARSMNGYPSYWNDDYPHRGELHVLSWYRSKDGTATWYDRKPVSAENRESSHNPGTQPQDYICMCEFQDSVATKPKHHNNLTALRSILTPRMRANSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI97</accession>
    <name>F9WI97_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 753</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_19010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002551">
        <property type="protein sequence ID" value="CCD17042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395074" evidence="4">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="66"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="19139" checksum="87A3D445CC9D0215" modified="2011-10-19" version="1" fragment="single">MVVTLRRLFVIGRKMMTRKMQLWMMVCFLLMGVVRAMVSRGPKGRPYAEGSDFNGDYYDYLCNVFQATAELWEASKKSNKVPNPELQSALDKALFGNYGKRDLQEIKKTLPEDYKQLRNRKEWCGSCKNSERYYPGRSITHDLMCLCAPGYYGEPFYVYYCPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIA8</accession>
    <name>F9WIA8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002557">
        <property type="protein sequence ID" value="CCD17054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15248" checksum="D12B1C6C2FB0039C" modified="2011-10-19" version="1">MLGYFPVFLKTAGGSDRNAYPVFAFSGTIVGRPACNGKAPSRDRFLPSLLETTGVLLAVAQRGMGRPACRATIDYPFSYRRRKMLFSVCLAFLYFFLFVPSRVSDRTAPMAKPPVSINPRFILFDFSMGNSLRGFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIB9</accession>
    <name>F9WIB9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 765</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_19220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002564">
        <property type="protein sequence ID" value="CCD17065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19220"/>
    <dbReference type="OrthoDB" id="1724786at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19499" checksum="BFB79BEE35185113" modified="2011-10-19" version="1">MEEGKISNKNYCYLGGRDRQSVCDGTSEEKVCATYERSGRRRENVKVQWLEKIESAVKILEEERTKPNVKAAESEGAFAGMIPAAMEEAAENEEPASQVQQFLEKIDNQEENGESQRKIPLSTEISNGAQEIIKKRSSPSAPETKIPYLATEVSDDSYLRTRYTWILLSALFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC1</accession>
    <name>F9WIC1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002565">
        <property type="protein sequence ID" value="CCD17067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02140"/>
    <dbReference type="OrthoDB" id="1721626at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16831" checksum="0685AB7463D002F2" modified="2011-10-19" version="1">MASWSLTRLESAPIPAKHLSVDIEPAHFASGWCPFLPPQLLGMLPAAAMKLFVECHNALLHAFTLTLMVRGMRNTSVGFPLLRSYNHTRVVATSPSLHWCCETPLLQTKQKKSRLFNNNTEDYGPHASYHTKKTYPPTNLNNKNNISMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WID8</accession>
    <name>F9WID8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002572">
        <property type="protein sequence ID" value="CCD17085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19380"/>
    <dbReference type="OMA" id="CWLITPL"/>
    <dbReference type="OrthoDB" id="58737at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="616" mass="68490" checksum="BDCBD58697C920D0" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII9</accession>
    <name>F9WII9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 800</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002603">
        <property type="protein sequence ID" value="CCD17137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19840"/>
    <dbReference type="OMA" id="IHVLYSC"/>
    <dbReference type="OrthoDB" id="180434at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="DUF625"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="SMK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMK-1" evidence="2">
        <location>
            <begin position="188"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="859" mass="93954" checksum="13EE4114AB42DBBF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT3</accession>
    <name>F9WIT3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 830</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002636">
        <property type="protein sequence ID" value="CCD17231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20670"/>
    <dbReference type="OrthoDB" id="1715555at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16632" checksum="BC9378717FF1D1A1" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTHAPCRGQKPQCGQQLLHAFGLHHVPRVPGCAWCRAVVVTLACGNTRGNCTSAFYFIPSSCSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG0</accession>
    <name>F9WJG0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002719">
        <property type="protein sequence ID" value="CCD17465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22840"/>
    <dbReference type="OMA" id="MGHILAD"/>
    <dbReference type="OrthoDB" id="1344217at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="567" mass="61873" checksum="F72A221DFCA9BA71" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJM0</accession>
    <name>F9WJM0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002745">
        <property type="protein sequence ID" value="CCD17526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17491" checksum="FCE42EDC7170B4B6" modified="2011-10-19" version="1">MVATCARPFFFLFMQLWIVEWCLRFPFCFLLSLHPSLRFCSCFLSFSFLFSFFFCFSYFFPHAVVRFFRLVNDCMGICFTTRSLANPCCCVSVCDRLHGANMWKSNNNNKIKVSKAFVSLSPPFRLCYSEHPFVCAYLHTWAFPQICCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJN6</accession>
    <name>F9WJN6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 932</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002749">
        <property type="protein sequence ID" value="CCD17543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23570"/>
    <dbReference type="OrthoDB" id="1702469at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="201" mass="21826" checksum="1C1958EA9AB69C0B" modified="2011-10-19" version="1">MLTLSQRRDLVQIGIRGLLGEVLLQVFRRDQSVDETVFDLHRNVVLVMHDQRVEHPPAFAHFQGDGALGTSSFFAQGDDLASVPMPAGGDFIGDVVHFKQGRLAFRLGNKRTHTLHTHQQAFGGQLAQGTVDGHAAEAQLADQLAFRRHAVMGRPVAVEDLLADHLFDAGIQGRRTFVHVGSQRELAGGVAQGILAGEKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ3</accession>
    <name>F9WJQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002754">
        <property type="protein sequence ID" value="CCD17561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23720"/>
    <dbReference type="OrthoDB" id="599210at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045221">
        <property type="entry name" value="Sphingomyelin_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21290">
        <property type="entry name" value="PTHR21290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="32731" checksum="BAF0EBC4079A9D23" modified="2011-10-19" version="1" fragment="single">MFMGLWEIVSSNTHSPCTCCYEYPHWCLSPATHPLLPIHTLGLEATVMSERQATRCSNHLRGRWRTPLPLWTQLMRFLLVLLISTFIIAVALVVSHERMPDPKVTKPLPDLGFEIFAKVPKLSLLADLSIGCLSVLSAFTSLKLYLLHRQAMGLGEVEPSFKIPVLNRLLFSVWMCKENCSLELRNVHLIAWIRFVTSYSLLLLFRSVVIVTTELPTPVDKCQDPPKITNPFEEHNTHCHNGWGWFPSTVATSCSVATLSYSLCTLCFSGCTGRWCPGGFRPVRPVGRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJW8</accession>
    <name>F9WJW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002783">
        <property type="protein sequence ID" value="CCD17626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24320"/>
    <dbReference type="OrthoDB" id="1683704at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="325" mass="37187" checksum="A0D8CA6E7E354744" modified="2011-10-19" version="1">MPKRLAWSREGDEDDSWLPERPQPQSRKEEAALLPEDDEWMVAIRTTKRQETRNPSPAWTMRSAIREVLLEGMKDPHNLNLFDFLQLHYRYVPENVARFTVGDFLRNPERCMKDKDRRKDIGMSMSQMRSRLRERLLHVSYDLFSYHIQTLGDWAKKGRSERVEPIARSLLDEAVKQAQETPTQAEERVQAEEPVQREPRGPRQVPVFLPSSSSSTSVSSGSSCTRRESSPSSDVEFLVESPPPPKKEENSSPHGTQPAPRRKRRASASMESLREASPPMPQEVAPLGTPPTRQPSQESYSDVEFLGANPPPSRAFCRESSPRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX5</accession>
    <name>F9WJX5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 963</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002784">
        <property type="protein sequence ID" value="CCD17635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24410"/>
    <dbReference type="OMA" id="LEDLNCH"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="33947" checksum="E75D6862B9B40CAA" modified="2011-10-19" version="1" fragment="single">MQSTRKTPSRKQREGDEKLSATPDSTLQTNAHPDPEGQSPLTWSLERRLNEVLLAKGITEAEEILHEYLTVAFGVSFWRPGIVMKMFLENPATYVKDAFTCLSLASSELFIGFKELHEAVEAIGKTNRERMKHIRQLPCVLDFLRCHIGRAAEGRLGAALSAIRRGKERGVANEGTSSVCCADALAVAMKVAAISGAAATSEAVSAVADATAFMKTAVALKPWTREIKGAYDSVFNAAWGHVLTGDEYRDEPLGMKVVVGRPELWPRAAVDIAPELEDLNCHNLRSGALAVAVLTSKMGWPDAHFATPSCEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK12</accession>
    <name>F9WK12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_02670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02670"/>
    <dbReference type="OrthoDB" id="987268at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="PTHR12560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="125"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD17673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="45459" checksum="DFA8CE9255B67D45" modified="2011-10-19" version="1">MALHPRGELYAMGPERAREYGFVSYYNHTGNETLDRLTNNITLTTEEWLQLVTSPVQFILKSGGWGGLGIDATVLSQLFPCLLWTIVFAGLRFFAQKQLSRLGLWLQVVVPRHGDKNNMTTSQRLKLKKFQNQLWLTVYYTASTIFGYVILRDKPWFGLPVSESNRIALLTPHPYKPEVELLRYYRYGLGFYIAEMAALVVEIDIKRSDFFEYFIHHVVTLLLIIISHCSYEHRFGVYVLFIHDASDILLALGKVINYVVKGDGNRMRNRKAGKSKNAAANAPVSRLYKAIFNDSMLTACFLMFTVLFLFFRLLCLPFLALGNIVYGVKIRMFTWSFAFLIFLLAGGIARAACVLVHTNSENIASTITGKSVEDIRSEDDDDDDDGGGEALPKKSKRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W372</accession>
    <name>F9W372_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1012</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000365">
        <property type="protein sequence ID" value="CCD11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25510"/>
    <dbReference type="OrthoDB" id="733478at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="22318" checksum="0FCF964ADCBBCDB7" modified="2011-10-19" version="1" fragment="single">MGCQQSSVRMAPRGPNVAGAAGLSPLIPAVPSESWYAQELEEVSRMTFTQFHTMQRGNVVFSKTCVPVGSSELEGLPNQAPPLAREVVIGKDALYGMAYLHDTALFMEHQWRLRVAHYKSTCSPTFDAKAFGVPSTDEEKVRLWDLKKTVYERPCCDTYVGVKVYVNGELVPDLFPTRTSLPQCTSTFESSEVFNNWRCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M7</accession>
    <name>F9W3M7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_26980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000438">
        <property type="protein sequence ID" value="CCD11748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26980"/>
    <dbReference type="OMA" id="QRSTCWW"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="334" mass="38501" checksum="A948FB5EE7636DF4" modified="2011-10-19" version="1" fragment="single">PEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDVEGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRRRIGEGGSWGPEAQVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRASLLWTTDDIVFAAGYCTTLSKDAAQAVVSYKPLAALLRKPYSIWHMMQYSSMSVMHEDIMVGRVLREKIKLDHLVIVNVKECRFHDVPNNLERRITNNSVVLHHIGELHYFKLLRHFPTNATPPAPSPIRWVNGYTAILPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z2</accession>
    <name>F9W3Z2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28100"/>
    <dbReference type="OrthoDB" id="1699732at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="258" mass="29492" checksum="81FF44470878AEB1" modified="2011-10-19" version="1">MVYWKFLKNFHFFLFFQMEKLMMKVFWLTMVLGVASANGKKTATCQLDKKEAGALCSLATALEATYKIAEKYDEHSLKEASENMTWLERNFDQSKRALLEHLQELEKTKAYTIEERMLLGVVVVEVARENENLYRSFEEASTHFREHWHKAKAAIKKALGKKEGSSVNCNETQSTLSHFIRCLAPTTSPLGTACEGQETRQNLKEGSGGGILETTLEAAWRWVSLRMRRPSSERPACQSTTVWKNSILEATQHMKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W471</accession>
    <name>F9W471_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28920a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000522">
        <property type="protein sequence ID" value="CCD11959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="20" mass="2262" checksum="E6352F7B2C78D706" modified="2011-10-19" version="1" fragment="single">SIALENVERIMPSSESRVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V6</accession>
    <name>F9W4V6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000616">
        <property type="protein sequence ID" value="CCD12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03210"/>
    <dbReference type="OrthoDB" id="1719090at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17008" checksum="FC5ECB69B23F707E" modified="2011-10-19" version="1">MWQCEYGPFVTGTSHIAAQPHLQSTDVRGRPIAPECVTRCGLAISPRGIGLPLSHMIHNSHRRDVYSLLNVCHGSGVVPLLVFFVTLHCLYVFVPLLTCPSFHFPHSRTTSAALKAGNEYEQIIQMEGRGVRRTRDETEGGVIAPVERAPAHAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W507</accession>
    <name>F9W507_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1260</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000641">
        <property type="protein sequence ID" value="CCD12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31540"/>
    <dbReference type="OrthoDB" id="1636791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="27602" checksum="0B69E23619CDD71F" modified="2011-10-19" version="1" fragment="single">MFRWTGGSKARATLPKDSSLRANITARGASDDCNNGSNPTTAAVADGRDGGKRINSDVPRGGGPDEGVPYLSCGRRRSRRRSLSESSSEDDKRGVDCLALDWSVKAATTKGPEGRHVAEGGVAHVTPLPTAKRTAVTKASGCTVDKSGKKESITGARRKVEKLSTSDISESNKQPSVSSFSSRFRANSLPNGVSVNLHNCPGATSVRGCGSTLSSQHSDRPRFRSVPSGWSGCPAFHHAVDDVYIDNMDRSFYRRDSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W514</accession>
    <name>F9W514_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000644">
        <property type="protein sequence ID" value="CCD12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31610"/>
    <dbReference type="OrthoDB" id="1710125at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21347" checksum="4B0ACA76D413F102" modified="2011-10-19" version="1">MQTHIINTPRETPWSMEKDVVDVLLDGVTSADSINLYWFLRPVLDCLPVDLVCFTLRDFVRNPRHCIPESNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPPPYQPYQEVVVVDPTPPFIQVPYSTMGYLVPIPLSPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W527</accession>
    <name>F9W527_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_03260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000649">
        <property type="protein sequence ID" value="CCD12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03260"/>
    <dbReference type="OMA" id="CWTTAGY"/>
    <dbReference type="OrthoDB" id="1265605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009944">
        <property type="entry name" value="Amastin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07344">
        <property type="entry name" value="Amastin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389893" evidence="2">
        <location>
            <begin position="23"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19958" checksum="743FFA1D3BFD178A" modified="2011-10-19" version="1">MLCCGALAILLILFAISASVCAIIFPVFCKYSKNYEGLQTLLYFWEMVGKREKKTNVRDSECYEYSLHFQVALGSMATSAVIGLLALMFVIALIVLKDKMRHIKIVSLSLLFFAFLASGACVALLVLGYFRGYCQDNKSLSEKYKSFRGREFKFDIGLYLAATTCLLYLLGNVTHCCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W544</accession>
    <name>F9W544_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15155" checksum="083A213E3CEA4395" modified="2011-10-19" version="1">MPTTLFETVVLHNTDYVAPGPRYAALAAPTNYLGKVTSLIQSVRTKKESRESSLQSIRTSRETPKTDLTQLKSLHISPSSTLAHLQQNPHTPDVSHNSTISHNGTISHNSTTAAMWAVSLNCIVTFSRLTQSFCVSGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W649</accession>
    <name>F9W649_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000821">
        <property type="protein sequence ID" value="CCD12652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35130"/>
    <dbReference type="OrthoDB" id="1697020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22813" checksum="A4D438F099A6D772" modified="2011-10-19" version="1">MKRVLAPRVLNRQEGSVLKLETTRLQGWPLVRGYMPCNPCPNPQLFERVAGMRKGSISGSSWRCIEKKNPWGRALIPTGNAGAEARTHCMWPEDIKQQWKEIFIAAAPHLSQAPSHAMPLSQGQYAPFPKLVKSLSDTSVLHPSVIMNTRLEFMNCMAARRVGDWSDGQPQPQQLGIRAQWPSSDVIPQLLYTLLHEEAVSAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W683</accession>
    <name>F9W683_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_35470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000832">
        <property type="protein sequence ID" value="CCD12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35470"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389925" evidence="5">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="56"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38729" checksum="0273F72154416783" modified="2011-10-19" version="1">MMMIMMLKTIKVMMLLGVMVTEATHSEIDNHNVDEHDKLCAFLQAAVAKYNEVKHSGSPLARGLRKAIFGVSDSNGKTPSDLRMPEDYNKPEDQDTENTRKNWCGLCENNGQKHYPGESAPHDLVCLCTTGQNGHPISGRGKKKLCGKTGDELGSAGKQGWYTELFKDVDKGNNQIKSTWNTIVTACLQDGNGKNFETALKTFTQKLERVENQSQLLLGNKKDGKVCSGVPSEGVCVLYHLQCARKPWWKELEEAIPEHEKWELEKLAEEKEQKLKDSKGPQTATEKLDQTLQPTLRVYNTPQNDETHDHLKAEKLIANITSTQKEDGSQIIRSQWLFLYDLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6C5</accession>
    <name>F9W6C5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000848">
        <property type="protein sequence ID" value="CCD12730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="14771" checksum="4039706DE9429B54" modified="2011-10-19" version="1">MSLAAFPTPRPPRHARRLPVFWYHHLMHHCPPHPLLDGVFSTGHVEPLLWRNLNKTNNYLGMWQNTPTNCPPLFFFAYRPPWHLSFSFFFYAQPTHVTTTTTRQQRCGKGWAKEEQARFFFVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D2</accession>
    <name>F9W6D2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_03600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000850">
        <property type="protein sequence ID" value="CCD12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F9W6D2"/>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03600"/>
    <dbReference type="OMA" id="DEKIPYW"/>
    <dbReference type="OrthoDB" id="865289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018539101" evidence="2">
        <location>
            <begin position="19"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="36991" checksum="0DD42B4868BB3316" modified="2011-10-19" version="1">MRVYVALCLLSTALVALGASALLAKDAPVLTKTFVDRINQLNGGMWKAVYNGKMQNITFAEARRLTGAFRRKTSSLPPVRFTEEQLRTELPESFDSAEKWPNCPTIREIADQSACGSCWAVSTASAISDRHCTVGGVQQLRISAAHLLSCCKDCGDGCDGGYPDSAWEYYVSHGLASSYCQPYPFPHCGHHGGKGKKPPCSKYDFHTPKCNTTCTDKAIPLIKYRGNDSYVLLHGEDDFKRELYFNGPFVVAFQVYSDFLAYKTGVYRHVSGDFLGGHAVRIVGWGKLNGTPYWKIANSWDTDWGMNGHFLILRGNNECGIESTGYAGLPAIPRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6G0</accession>
    <name>F9W6G0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_36180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000862">
        <property type="protein sequence ID" value="CCD12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36180"/>
    <dbReference type="OrthoDB" id="1524940at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18422" checksum="014876B5A2B9FD94" modified="2011-10-19" version="1">MAFLLLISSAAALFVALRRGISMAHSARGTFAGLLCVPNMGLMLWVELPKAYTEGHYTAVNYHLLSWMFILIGAYIGYSNFPEAQISQATRQWSKGANRRHTIGFRCWRWIGRYLLSRNDLDYTWNSHNIWHYCVMLGVVAKLFGCRYDVVEFELTRCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P1</accession>
    <name>F9W6P1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1494</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000901">
        <property type="protein sequence ID" value="CCD12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36890"/>
    <dbReference type="OMA" id="KHRSPYV"/>
    <dbReference type="OrthoDB" id="989546at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="659" mass="74613" checksum="9FD715C9BDCF826E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T5</accession>
    <name>F9W6T5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1525</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000935">
        <property type="protein sequence ID" value="CCD12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37300"/>
    <dbReference type="OMA" id="MHIALHE"/>
    <dbReference type="OrthoDB" id="1174601at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="467" mass="50494" checksum="4DEFD699FDCE8BA3" modified="2011-10-19" version="1">MIPPKISSHQELTLRRVNVQQQSFSSQRSGSALSPTGNATTSYGSNSGVPRAAPPRGDTPVQWGSSGAVSVPTAASAPNQKTRLQVLDAPLTGGGTNSTAPASIARPGVRRRDEWAKALSEVQPFSAGHRPVSNSSLVERNVVVHYIADQYDRQWLAQAPGSATEGENNRGNILLSGETTPQEPKTVRPNISLMMFEKLITAFELHSYANATTTVDQLSVSALDNVVSTGADAATIEEVRKYWISKRRALGGGIPCIPALRTNIREDNQQILCRAGILQYCPLPFNSRDCPVPLVRRAAPCQREKIKVEVEHNEDADDEPEIAGSKRRRRSSIRAMKPEHDDGEVTAEAGSVERHVVLTAAHKVALAVLEREELKLVHMHIALHELALLRQLAVLGSDLGTPTGSPSLDVSRGAGFTPVGTSWATEDALRQEWVDENEVVGEVYDGATGRKSTAALESVMAIERRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7R6</accession>
    <name>F9W7R6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1645</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001070">
        <property type="protein sequence ID" value="CCD13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40070"/>
    <dbReference type="OrthoDB" id="1718252at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17529" checksum="8F46E7D1969C6369" modified="2011-10-19" version="1">MGAVGRKRPNEPIVCRMEVLYSRMSFQEGEGVIFHWLTNTTYILALNPDDRKLHSIVLQETQLGRLVPLRARVYCSGHISTSKDECVLRSSICMHLSAVMPGGGGKATFMPLTQQIPFVTRQAAARCAFYQSLRRIKCLFPLLLKISLTSGPLCGDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S0</accession>
    <name>F9W7S0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1646</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001071">
        <property type="protein sequence ID" value="CCD13242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40110"/>
    <dbReference type="OrthoDB" id="107959at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20570" checksum="E0F1B903FA1E2FCB" modified="2011-10-19" version="1" fragment="single">MSKLLNVAKNEKIQLLLREKDDSPHVIYHTERPLRIQRHGRGKKVMLVATSFNLYLIKVKGMRFYGRWPNTCFLTTTSGNSITIRIDKEWLDEVDPDGKRMFLSYGVGGEFESVELLAASSDEMLNVQHNLKEISRNARAHLQMLETPELRPENGNATCAGGKKVTFEEADEEESDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7T9</accession>
    <name>F9W7T9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08500</name>
        <name evidence="1" type="ORF">TCIL3000_0_40300</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001080">
        <property type="protein sequence ID" value="CCD13261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002077">
        <property type="protein sequence ID" value="CCD15853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40300"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20118" checksum="9313E0D1DEE34BF2" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPLIHSYVSRFSIIDFARNPWRCVGEADGREQVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQTRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Z3</accession>
    <name>F9W7Z3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1679</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001107">
        <property type="protein sequence ID" value="CCD13316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40820"/>
    <dbReference type="OrthoDB" id="309166at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="147"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="43391" checksum="0727268020350779" modified="2011-10-19" version="1" fragment="single">MEHSERLKNKGNACFTDGDVKGAKEAYLQAIEYLEKMEVGRNDGHSSENSDVGRMLAILYSNLSNVYLSQGKYSESWKAAEEGTRRDPTFLKAWIRYVHARRLDGYPFEAFVALLRYVRPLLRKEPPSSAAKTVRDLESEINFPLYESLGLSNVSPHIALQDFESGVGIVALQPLKPNDVILVEKKFQASPVDVHLGPQDCSTTTEIVLSFAQKALPHQRRRSDEWKRLKKEFEGCWPRSPTDVPSDIQNLVMGEVRPLLPRMSDTDFEELFLVSMMCRYNCFYHGFFRACALANHSCVANAAMKFDAASNTVTLIAVRPVEAGEFVNVKYLSDAQLLMGVGNRREYLRSWLFWCSCERCTSDNDPNAFHEHVQCTSCQQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W818</accession>
    <name>F9W818_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001121">
        <property type="protein sequence ID" value="CCD13344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04430"/>
    <dbReference type="OMA" id="LAPFKGQ"/>
    <dbReference type="OrthoDB" id="1483113at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17718" checksum="F54BAFA518A3C726" modified="2011-10-19" version="1">MPTIYDFEVLGGDLKPYNLAQHKGHPLLIYNVASKCGYTKKGYEVATNLYEKYKSTGFTVLAFPCNQFGGQEPGTEKEIKEFACTKFKANFPIMAKVSVNGSDAHPLFEFLKKAKPGILGTTAIKWNFTSFLIDKNGVPVARFSPGASEKEIEEKLTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W862</accession>
    <name>F9W862_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_41460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001139">
        <property type="protein sequence ID" value="CCD13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41460"/>
    <dbReference type="OMA" id="HVEEMSA"/>
    <dbReference type="OrthoDB" id="190287at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="791"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="834" mass="90497" checksum="E945E145A5C20640" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D6</accession>
    <name>F9W8D6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42170"/>
    <dbReference type="OMA" id="HEAPRNA"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394606" evidence="1">
        <location>
            <begin position="21"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="750" mass="81641" checksum="67A3E36EB100BEA9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8G5</accession>
    <name>F9W8G5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD13497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42430"/>
    <dbReference type="OMA" id="CHERLYS"/>
    <dbReference type="OrthoDB" id="1302394at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="340"/>
        </location>
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        <location>
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            <end position="91"/>
        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="151"/>
            <end position="192"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="723"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD13497.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="819" mass="89313" checksum="7E505647C782133A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
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    <dbReference type="InterPro" id="IPR035969">
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    </dbReference>
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    </dbReference>
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            <end position="377"/>
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        <location>
            <begin position="134"/>
            <end position="174"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD13581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W939</accession>
    <name>F9W939_TRYCI</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
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                <person name="Quail M.A."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
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                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001257">
        <property type="protein sequence ID" value="CCD13729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="CESTEAS"/>
    <dbReference type="OrthoDB" id="655973at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="583" mass="63046" checksum="F3D21EA8763B0A02" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9A2</accession>
    <name>F9W9A2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1841</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001287">
        <property type="protein sequence ID" value="CCD13795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44950"/>
    <dbReference type="OrthoDB" id="1714720at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16652" checksum="F6ACD0C36D3D6242" modified="2011-10-19" version="1">MQPGQEIICTDAGNNETHFQCISQHPNAPAPCRGQKPECGQQLLHTFGLHHVPRVFGCAWCRAVVVTPARGNTRGNCTSAFYFIPSSGSTASQKSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCSTVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9J8</accession>
    <name>F9W9J8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45900"/>
    <dbReference type="OrthoDB" id="145210at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="637" mass="68600" checksum="481430247047CD76" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9L9</accession>
    <name>F9W9L9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001324">
        <property type="protein sequence ID" value="CCD13921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46070"/>
    <dbReference type="OrthoDB" id="1720351at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17062" checksum="F2489A3101982714" modified="2011-10-19" version="1">MGHTRTVTSHAHMALTPQLTATLHHWRQHLLQGRAAKVSWHHASLPATNTAHAILSCVLHPNAHRNKSRSSCTASGSTLKQIASRAVKVRWPFLTVTQHSSPSGTHAKPLHSLRKSKPSEVQAALRQYGPFDIAVPASSVCGDHITWLPSHREVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9N5</accession>
    <name>F9W9N5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_46240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001333">
        <property type="protein sequence ID" value="CCD13939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46240"/>
    <dbReference type="OrthoDB" id="1721669at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19666" checksum="24F2F0585808791F" modified="2011-10-19" version="1">MWRRRRYSSSSDAASRGVSRQLPPTPHPFRCSGMGFPGKQRGHIGVTGSVGFPIFLSQKVNEANVFPRLACLLGVLFQHIVLSPSRMALCAWNAGYLMCGLVTFSLLLYADMLSFVMGYYGCLRASLTASSKIHFRTLSNNVIAPRRAQSRRVMMPSPTRYRMSLVVFSCKRSDMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9V5</accession>
    <name>F9W9V5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001354">
        <property type="protein sequence ID" value="CCD14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05000"/>
    <dbReference type="OrthoDB" id="1697342at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23636" checksum="E641FF5F89540BBD" modified="2011-10-19" version="1">MRWADLPRAVPKPQAGTTWTGSREYGIPRRWQGVRAASQEEETVLPLQEVNVGALSLEWVRRRMEDEALHMFDEVWNLMIATGGTARRDRKSHLRIATGYAHKMKHAGVISHASDLPTKGWVIPFSVVEGRKTGEMRRFTAWPRVKQAKNDYEAEVPLDHMSQCLSAVYDESAALFDLKASFVQVDLSRDIRAGFRCRTESGELVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9W2</accession>
    <name>F9W9W2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_46970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001358">
        <property type="protein sequence ID" value="CCD14017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46970"/>
    <dbReference type="OMA" id="AYVNMDL"/>
    <dbReference type="OrthoDB" id="1427850at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="21209" checksum="22872A243B0E2A41" modified="2011-10-19" version="1">MLRARSAAGNGVAAGAAGFNITTALGRFFSIGVPSSATPRGMCAMGLRDSAETVEAIAEAYVNMELKTMRAFHELVAKQMQGPSGTNPMACEEMLLQGFGAGVAVNIARTAASAAGNSGGNQAAPVAAVPAAKRVVEKATVDVSVKSYPTGSKVKLIKELRAVTGVTLQEAKAAVEQCPGIVAKAVQRADAEKLKGLLEAHSAVVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9X2</accession>
    <name>F9W9X2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001361">
        <property type="protein sequence ID" value="CCD14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47070"/>
    <dbReference type="OrthoDB" id="1699512at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="24088" checksum="CA9A762761B788AC" modified="2011-10-19" version="1">MECVVSCMIYAAGVCGGVAIPLLFSLENSAMALISSKHWIGVSFRSGLTTGKCVDIGEDVCEHVITKHTSGPTTNPAGSSHVGHGCFHASAGSDVILIFGSFFMSGRCMGNGASYDISRRSLSASPLALPAFYSRFKGPLHMCVDNTAVMRIMNEGNTHSNALVHETSAIDRVLRAARINAAWSYVPSTINPTDGVPRGCVSGDRTWRVCVRVRRVEDTFSPSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9X3</accession>
    <name>F9W9X3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1908</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001361">
        <property type="protein sequence ID" value="CCD14028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47080"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18738" checksum="AEB9F456A63F6464" modified="2011-10-19" version="1">MIATEGIAKRGMELHLRIATGNAHVMEQAVVSSVMLLICQQKDGLHHFLWWRARCRPTAWSEVRNTKNDYGAEVPHGHTSQYLSAVCNESVALFDLMASCFNVDLSRDIRACFRCHTESGELVELDRLPMGYEGNTEIVHTITRALAGDADVVRTEHAAPNHLRMHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Z9</accession>
    <name>F9W9Z9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001367">
        <property type="protein sequence ID" value="CCD14054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00520"/>
    <dbReference type="OrthoDB" id="1716557at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18274" checksum="853320B06B9847EA" modified="2011-10-19" version="1">MAAPATSTWFRGPAPCMGESKVSAPNLVFRELDGQKASGCRGWVMQQRQRFSGAARSIILPAPNGECTSLCCFQQLLLPGGVFNVTVARLTFLQLFAGARKLAPDFVPSTVRKLQLLVAGTSFLSSSDNVGSATFECILRATPSFFLFKFMHASGLGPLSTSTISSFKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA55</accession>
    <name>F9WA55_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1938</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001395">
        <property type="protein sequence ID" value="CCD14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47750"/>
    <dbReference type="OMA" id="TAHAETW"/>
    <dbReference type="OrthoDB" id="1061700at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="302" mass="33463" checksum="4C711450670D69A9" modified="2011-10-19" version="1">MNSDGSEMAVLQDPSSYTRSIRKDSGARWVQGLTPIEPEDGKKLDGPNAGRRRAVYLVNHWLRAPLVFGICHLVIAASIVSGLYRPCVASDSGRRPELLDFPMDESELEKYTAGQAETLMQYAAKVRHVWLVSVPLTLFSLSLSWKIGVSAHNFPSLCGVGVSILSAVATVGQFLVLWTACGVREGGGSVDCNIPFVFYWCHAVMRIGGPLLSVFLCAPVLDNVQNKRLFWKVTLSIPFLCFLAGATYLICNINGKLGASGYRFDVLYWCCCATLLTWTPLLVSCYRQPRFRATYEPKEHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA89</accession>
    <name>F9WA89_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13708" checksum="417C9861A1E9733B" modified="2011-10-19" version="1">MHPLISWNRFALPSLSHVERIRLRTMLKIKTSSLGTWERRFGVWHLLLTLRLPVSPNQITGVKPRSPCISTLTPNSEEVTSPNKKKYHATALRLLPHPSPVGKKTLWINSINILQKVFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA99</accession>
    <name>F9WA99_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48150"/>
    <dbReference type="OrthoDB" id="1657669at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="574" mass="66693" checksum="DE45A6D9B0769A6F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAF7</accession>
    <name>F9WAF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1968</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001428">
        <property type="protein sequence ID" value="CCD14219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48660"/>
    <dbReference type="OMA" id="HRANEAS"/>
    <dbReference type="OrthoDB" id="643454at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="476" mass="50988" checksum="C60E4CE85BB28CDB" modified="2011-10-19" version="1">MLGSRRLVGSLPADISRSSLFQHAKQLLHGQPSADTFIAAGGDVGAQQKLGQKSNANVGATRVLLRRNHRANEASRESPEVRGTFTDGGNDGGSGGSMSGDLRAYEDWSRKVGACSADEFLHGVKHSYRCLGVLVETLSEAVWQKAPVGKSMAREAALAKLQMLLSKEYGVKEDALGKVGLTHEDTQRNFPSACKEVSQTLMTVLPLSEGLAEFLYTTWEKHRTFDYNLMCIAAPNDYIIKADIAQFYAYTADEGATAPVQPAGVEAAPSPSEAAVGTVNAAANEQGNPNRDTATGTADVNKEGPAPQTPAGSTPAGNACKGSKKSENAIRTLSQKGIKLKPIPASAPAVVLATIDVVTPPQRYFPSFDWFYQRIIGHANEYERIEAARVCAGSSAGGVLVFMDFIKRMFTGRSIEFDCTHAATKLHGATLNIGNCPPAIRKLLCFYLDGDNRWVLFDVLTVDRVLTPMTGGAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAP0</accession>
    <name>F9WAP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2000</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_49450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001463">
        <property type="protein sequence ID" value="CCD14311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49450"/>
    <dbReference type="OrthoDB" id="1425797at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="566" mass="58053" checksum="BA69012A5A980C5B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAP9</accession>
    <name>F9WAP9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001467">
        <property type="protein sequence ID" value="CCD14320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15519" checksum="05776B14F8B99960" modified="2011-10-19" version="1">MVAARNASEVKVPQLVSFMLTWRTGFPSNRMGKSRLPRKSERPAATLRKSSIIFSAGAFVRKRLRTRRFHPTDERNAGRNNAHPALDGSVQLRRALGAEASRVQATSSRTRTGRNPSSAGIMSLVFPRFAIFVENEPDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT1</accession>
    <name>F9WAT1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTMP kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00560"/>
    <dbReference type="OMA" id="ETHELAY"/>
    <dbReference type="OrthoDB" id="1318381at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="135"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="39570" checksum="DB31D30DD1FEE3E9" modified="2011-10-19" version="1">MMRKVVVFVDVKSDELCSVIQQQVAKSVAEAEIVFLEGSFACTLNRRGRWMVDSVGTFACFITEKTLDHADVVYAVYYMRLPVLSLTEGRRARVSILETPSSLGVADGGSTIEGRAEAVRRFFAFEPTKSAVIVFEGGDGVGKATQTAYMVKRLGSEGHRVGTIDFPSDIHRYGDLIREILSGKKGGIRDLDPKLFSLLYSLNRFDCLNELRYWMKRGTKVVLDRYYTANYGHQASKLSEDERVDFIRHLELVEVGWFQLPPSDAVIYLDLPPPVALTAMKGDNKREALDIHETANVSYKEDVRRTYMWCCRNMPGWFHVGCCTDEGVRHSREETHELAYGKIKHCISKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB44</accession>
    <name>F9WB44_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2058</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001528">
        <property type="protein sequence ID" value="CCD14475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50850"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17359" checksum="0FB596227C50F82D" modified="2011-10-19" version="1">MWELETGRTYKPLIPNFPLVDGSFVVEGVGPNTIVLLQVTKAKEHHTKRTTVRKFRQCMGKAFECREKVEKACSWEIMNVQHVDSGSIKKRWKCCTSGDAAGDEHLALWENTHQYRVSLNTDIASEFISRGSCWRRDPIRRVRQSRAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB92</accession>
    <name>F9WB92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001548">
        <property type="protein sequence ID" value="CCD14523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="14866" checksum="55C4E0A33F09457D" modified="2011-10-19" version="1">MQGPPVRHFYSGVEGIVKSFSRPKGECRNTGANCMCIPPFFLFGGQLTVLFICLTKKACFVAKARISLADILLGLTSVRCTRTVSTTSSQFCKSPKASTADSVFENSIFIALNSSPPVEMQHQQWHTLTNRRKCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC2</accession>
    <name>F9WBC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_51600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001562">
        <property type="protein sequence ID" value="CCD14553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51600"/>
    <dbReference type="OrthoDB" id="1676708at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394829" evidence="5">
        <location>
            <begin position="18"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="38039" checksum="FC5167C9580916C4" modified="2011-10-19" version="1">MMKFLVVVMVVIGVVRADEVGAAATLTNHNEASHRALCDFLKVAVDKWEHVKTRGPTDPLKKALKDTIFGYGSGEEDVEVLKSKLPSDYDEVGSGLLSDRSLWCGQPRDEDRVQQRRWPGHSGPHDLVCLCTAGENGWPVNSTSDTGSTLCGHNKDALEAGEKWWSGTKNMKKKDAIQKTWEVTVNQCLSGYSQGTDLVSALQKFKDKIKKTIFDDETRYILGEGGTGWSPCNGNAQVCVTYYPNRTSTNTWWSDLEKAFVQDEKIEKQRAEEEKRKQQQEAAKKDKNKTEDIKSTTPTTNQTEQNKTATLHETMRKLNLTSGTPIIPPSSWLLRAVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBI2</accession>
    <name>F9WBI2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52190"/>
    <dbReference type="OMA" id="DYDINHE"/>
    <dbReference type="OrthoDB" id="1654261at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="901" mass="101554" checksum="509288A012DCC58B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBI4</accession>
    <name>F9WBI4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_52210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001584">
        <property type="protein sequence ID" value="CCD14617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52210"/>
    <dbReference type="OMA" id="GHRVLCY"/>
    <dbReference type="OrthoDB" id="1182064at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="303" mass="33602" checksum="2C4090764D3CF6F8" modified="2011-10-19" version="1">MGNTTSFCCCCPTLFDEHTSRSPNGGEPRSNYRGATSSSFLNSGRFPAEGRIRCDLCGSLISAVMFDGHRESCRENNLRSLLASQQQQQQQQKKGCEEQRGETGIVEDCALWETDPDELCVVCLASRRAYAFLPCGHVSCCERCGRALTRCPMCRAPRSGLCNVSPDVFLQFKCRSCGLVIAPELHGGHREVCGLRMRLLQEKNDKKKDTNDVFIETEESDDMSTVVGVPYVDIGAHESSFPCGREETRCTMHVCVQCHSSETPLVIILPCGHRLLCEMCCKDRKTCPVCLHSIESSIKSFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ7</accession>
    <name>F9WBQ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001613">
        <property type="protein sequence ID" value="CCD14691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52850"/>
    <dbReference type="OMA" id="NEERHET"/>
    <dbReference type="OrthoDB" id="1654515at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="821" mass="92193" checksum="3AE500AB67F0E049" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT0</accession>
    <name>F9WBT0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001623">
        <property type="protein sequence ID" value="CCD14714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53070"/>
    <dbReference type="OrthoDB" id="1680221at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390121" evidence="5">
        <location>
            <begin position="28"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="385" mass="40704" checksum="EA92B51F398ADB4C" modified="2011-10-19" version="1">MKVLFGMRMKALVLGMVVVLSVGASMGTGHNEDAFDVLCNVLRSAEKVMNKSGQHSGRLKEALYGKPGGVVTVEKGQVSVKGNCNGQTNRGPVCTYYNGGRHGCFAESLAGTLLCTCTPGQRGGVFCGLGTPQNVNTWSGGSTPLEHRKDLFQKVWDEVRKKCPYGTEHEQGTREDDVGHLEKDVQRARDTLKQGLPFFYFGGRPGRNGPCSGAGPGDVCAAFHQGRSKGKHTVHIPWADTIKNVLPGINAALEPKAPHTVSAQATPAFSASTAPAIPIPSSSAESKESEVEPLETSTPTDTTSEEETEETHTPGTPSPEHPGSPKGRARRSTTEGPETTSTATEDTSNTDEPEILDPTAAPFPLADGADLLTPLGLFMAASSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU9</accession>
    <name>F9WBU9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53280"/>
    <dbReference type="OrthoDB" id="1723931at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="19490" checksum="375BB54140864046" modified="2011-10-19" version="1">MALSCMEALATRRKGRAGGAANVPANGVTETNQTAASFRHTAIGGLSVASSVGHPNERNPMNTAFVAVGPQKPKLARALEKRQVHAELQKAKSLKPMGERGCQTVTSLSEAASRHQRRVAGYLPQSFACNQFFIGMRRSNTEAEQHLAGTTDATAREVRKAVHATKPSRVVLGLPIVPVKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ6</accession>
    <name>F9WBZ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_53690a</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001646">
        <property type="protein sequence ID" value="CCD14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53690a"/>
    <dbReference type="OrthoDB" id="1682170at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="302" mass="32988" checksum="EA6E230AEC8C0A59" modified="2011-10-19" version="1" fragment="single">MMKRLGSTVPFLIVSIISGIIFPFAHDEKMAGDIADHFGILCRIYKVAATTSRNIQDPTEVSQIQNKADQINVSISDDKWFNELLENINDTDLGKQFKAENDAETEDWTRWRKAALEVNESKNFEKLPSGSTAARLARNKLKRIGSQMERVIEEIKKKSGASRLEEIAKLFKRAIYGNAQNEKDVNLYKGAVNRTKTCGGETGFSGKVAHAGKSLVLDFLCLCGKAENGEPKVCGQLVDVAATGNWNTATGANGENNWNIIKGACEKTEFPKSGLAAEGLRAVADFESVLSKGEKTTAPVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC42</accession>
    <name>F9WC42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001664">
        <property type="protein sequence ID" value="CCD14834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="15230" checksum="D0AA05BF7ACB19E0" modified="2011-10-19" version="1">MLDTSFFFVWYSLMFPSLMYDSPLPSHLSVFSSLKNYLSLPIIRNWMKLSPCGIRLFDVQPAVFFFYSNFSRFFHSFFPCFIPFPSHFCRWMTYVIRASIFRACACACDHHPTTHTHAVCPFSFPMTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCB8</accession>
    <name>F9WCB8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001697">
        <property type="protein sequence ID" value="CCD14911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54810"/>
    <dbReference type="OMA" id="YVPQPSY"/>
    <dbReference type="OrthoDB" id="1522976at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="328" mass="34343" checksum="76B4A84B4691949F" modified="2011-10-19" version="1" fragment="single">MSSGAKPHPDHFIPIRPAYDPSMPPPPGGSQAAPPAPGKDHQIHYAHVIPAYDPSMPPPPGGSQAAPPAPGKDHEIIPARVPRAYDPSMPPPPGGSQAAPPAPGKDHWIIPAIVRPAYDPSMPPPPGGSQAAPPAPGKDHRIIPAIVRPAYDPSMPPPPGGSQAAPPAPGKDHRIIPAIVRPAYDPSMPPPPGGSQAAPPAPGETKRMFPDYNHQAALPPGGSQALPPDYYQRPLLTGNGQPPHVERGGGLANEPAGEDRSAVNEWETGLLVAPCRQPCFCLCSCCCPCCCTYLQRKKLLQGDWSRYSCCAGICCKKTCCVIRMEPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ8</accession>
    <name>F9WCJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001731">
        <property type="protein sequence ID" value="CCD14992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="RSTNMDQ"/>
    <dbReference type="OrthoDB" id="1413484at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16914" checksum="BCDD7FE08A90ADDB" modified="2011-10-19" version="1">MGKKQASCGLQTDPEFSFIKKGHLNVIIHTKDGEQKMVPADSAAFIDNPQLTRSRTMDQVNFNNECIFKVTLDFAEPIPCIEETAVREMTDWVLCSCKGNNAFYSPVEKRLVLQNCTVCLQSNVRQLLDPFVVVLCLDEETWVVERVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCM8</accession>
    <name>F9WCM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2249</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001741">
        <property type="protein sequence ID" value="CCD15023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55890"/>
    <dbReference type="OrthoDB" id="1752299at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="23821" checksum="85B27F0C40A959C3" modified="2011-10-19" version="1" fragment="single">MPGWANKSCSLTMRIMSRGQVSWGIPPHSTAEKCSAARSSSTHTPVSTARASSAASFASPSAFSASLFASPAVRTSSSRDFSLTTNTAPYMRITSAPSGTNSARASNADSRDLDVTSAAAPVHFFAAVRMGSSAFSHVASRRSDSSVVSIASFDAAVRSAACFLASPTTVSARWAAAAALAAASVAASTPRFFDLARSTAFSARSFASDASRAEETTAATADWEAVSRPSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ1</accession>
    <name>F9WCQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_56120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56120"/>
    <dbReference type="OrthoDB" id="1665491at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394678" evidence="5">
        <location>
            <begin position="26"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="29"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="104"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="425" mass="46562" checksum="B7436F7A015E0592" modified="2011-10-19" version="1">MACFINFIVVSLAFGSFLKHAVVQGQNNVVVQGSDNAEQFALLCRIYNVAKNPPINHVDLQDPHKIVNEIDALNASIGEDKRFNETEQMENSTEVQLKPITTREVAVAQAILRRIAQKAHTILGEITKINATTDIEEAKAQFAHVLFGELKNESRLCDGALNGVQERGAVCGNPGTGTKGSYAGKNLVVDFFCLCAMRTGERGKEKEGVQDACKVKVGSKSEKHSWDSGAPSGSSSMWASIKKECGNLLHQHTMSTKEGNEVIEDFLKHLKGGGLYRWGSTVEDSGQKKGMLGTGVGKQDSTGGSGPVCDGSRGNTKGTPPAGICVYYGPENWEENIEWLKKLKTALDLVDTLNEKTAAIQQSIEKLHMLLHRAEEIYENTKVITEIQHPVVPTNMQTAAKRLTAYNAAQRYHPYHFILTWVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD75</accession>
    <name>F9WD75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_05910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0602 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001833">
        <property type="protein sequence ID" value="CCD15226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05910"/>
    <dbReference type="OrthoDB" id="1015843at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029358">
        <property type="entry name" value="DUF4586"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31144">
        <property type="entry name" value="PTHR31144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15239">
        <property type="entry name" value="DUF4586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20720" checksum="93151F37BF03BB19" modified="2011-10-19" version="1">MPNDLQTRGPRPFPQMKPRQIYTAPSKSGGYGTPGLWISDVGAEYIATIYDQPRINAKQEREAWRKRISSVPFKPVGRQGYTFDEGLATGASMCYAMTRPFMAKPVQQDMKHFVIDKLWLPPGCIPERPPPVEYWEDPYNGFDPRVDPKSRLKKPSDSFFKTGFRGDNFFYTQSIVFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDB0</accession>
    <name>F9WDB0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_57980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001847">
        <property type="protein sequence ID" value="CCD15263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57980"/>
    <dbReference type="OMA" id="NNESLNC"/>
    <dbReference type="OrthoDB" id="1248958at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="699" mass="77627" checksum="1AE6BB8943833A5D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDB1</accession>
    <name>F9WDB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001847">
        <property type="protein sequence ID" value="CCD15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57990"/>
    <dbReference type="OrthoDB" id="1724271at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17055" checksum="51F392A2B519E41F" modified="2011-10-19" version="1">MWIGRVSPSPHEAIRKHCPDGHTFVRKRFVDCVRTGAGWCSVTCDLPSHFVSDPFCYRYSHTPFSLSCLECHCALPQLLRIFPFVRLTCSTFSLRNGLTTHNGRLTFVLLTAWVAAFFSDRGPHHLLTFYFRPRVALRAVAVRGNVSAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDF5</accession>
    <name>F9WDF5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001863">
        <property type="protein sequence ID" value="CCD15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="99" mass="11223" checksum="465F187C2EF4AEF8" modified="2011-10-19" version="1">MQSRSSRANTRFITLRSVWLSLEGLNSDMLFAGLFGWKSRMMRLCYTFLEHDPSSDRDGIVSMHAFCRASTIASGPHTAFHRCLQRCSTTAHAVQHQAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDG3</accession>
    <name>F9WDG3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2359</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001863">
        <property type="protein sequence ID" value="CCD15316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58470"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18115" checksum="A942F3F74351954B" modified="2011-10-19" version="1" fragment="single">MPPHSGKQAKGEIPSANDVTGQPDGVCCGSAAHEAPGWTLNSSVASVLLEKYGGASGMTGAAFLQKYLNNAWNVGDVSLRVLMEDTARYVEEESTRAILKRSAEWRECEALHAAVADLGRREVHTLGQWENMTKRMDFADTLVKDPLHAALLCAKQGMTSSTPEVAQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ1</accession>
    <name>F9WDJ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001875">
        <property type="protein sequence ID" value="CCD15345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58740"/>
    <dbReference type="OrthoDB" id="1714759at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23290" checksum="30D4CC14213E679F" modified="2011-10-19" version="1">MKWTFTCPAEVEVELAVVELVRASLEPLETARGFFRSLLHGARQYDAQDGQTLTTDTLQKAMRQVVFEDEGGGDLQTLAMRRWTTTLRYALDPETAMHEFLLAFLGELHTLDRQVGNHRGADAFYKAAGRIVFGEARPSERDLQTLAIQYVARSVLQSEDPERKARELLGGVLHEARQLDREHHHHQGEEALLKAMEEILPKTAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDP7</accession>
    <name>F9WDP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2387</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001894">
        <property type="protein sequence ID" value="CCD15401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59280"/>
    <dbReference type="OMA" id="LIAPCLY"/>
    <dbReference type="OrthoDB" id="725565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007498">
        <property type="entry name" value="PqiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394903" evidence="2">
        <location>
            <begin position="29"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="781" mass="85723" checksum="E54AC8569EE86B1C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDW0</accession>
    <name>F9WDW0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2410</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001919">
        <property type="protein sequence ID" value="CCD15465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59850"/>
    <dbReference type="OrthoDB" id="1749431at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16316" checksum="72D0A817D0262C5B" modified="2011-10-19" version="1">MDLLFFSPLWKASDKKDTMTENKQSEPKNQETEFIHVSSQSTQATRPSQDAPVRPEAPHYHLVSSTETTQREAQTPAAGGGEIAYIYISSTESSQAAAKKPGEDGGREPEITVISSESATPAPPETPTQTQGELPTQSAKRLREENKTGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDZ3</accession>
    <name>F9WDZ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001933">
        <property type="protein sequence ID" value="CCD15498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="111" mass="12279" checksum="94B70D17838314DD" modified="2011-10-19" version="1">MAVWDSVLEMEPACFAGEWWPRLTRWCGGSVRHCGTEPRLVVAVAVHPLKSPQTPRVWRAARDIGGIPSVGVVSRGTHNSRISESKLALSQISCYEALEVQSHLPHISLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN4</accession>
    <name>F9WEN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 294</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07560</name>
        <name evidence="3" type="ORF">TCIL3000_0_16500</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002042">
        <property type="protein sequence ID" value="CCD15745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002425">
        <property type="protein sequence ID" value="CCD16747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07560"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16500"/>
    <dbReference type="OrthoDB" id="1719477at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17828" checksum="534A707A30695A3D" modified="2011-10-19" version="1">MNTLYHCSSKLLSVSHRHHPLNPKPSLYSVSKAHPSAIPCSPLALPCHTSLRHKISRAIHLPALQPPLATLNSPKHASSRGIHHGDSLARLCFRVGNRSQEFPARHHQLPPASVLVRWGQSPMPQRKPNDINALNNRSLRQSRRKAAISSHSCRMRRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF14</accession>
    <name>F9WF14_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08740"/>
    <dbReference type="OrthoDB" id="1718953at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18428" checksum="14445AC7467597ED" modified="2011-10-19" version="1">MRSRPSTDSFVEYVCSTHSENEAGIPHLVVGQNLYAQLWVLSHNHFRQPPPAQSFQLLQLRSTVPHTFCGVFCVYARGASRRVKDADTRTRISTLIAPHACIGPSPHSSPLIVAVRRSTINCTAKTVMVRTRLQPNLQSISFQRENAAAMNRIFASPAYEFFSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF32</accession>
    <name>F9WF32_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 343</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002096">
        <property type="protein sequence ID" value="CCD15900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08920"/>
    <dbReference type="OMA" id="HNCIDFA"/>
    <dbReference type="OrthoDB" id="1300278at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="PTHR12378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="2">
        <location>
            <begin position="44"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="25950" checksum="E9E573275DA06256" modified="2011-10-19" version="1">MAGAPKGGSLLEFANKARDALSDVLSGLGPEGTRRSAPADLPSSTVFLNVYDIVRSNNVLYYVGMGVHHTGVEVYGMEFAFGRCAGDTGVVQVEPKNTPPHTFREQLVLGTTKLTRGEVVALLQEFKGNREQWSGYSYHLVRNNCNHFSEAFAKRLLPPDVRFETYQEMMMGNGSNDVVEIYDNGERETVQLSNGNSVTVPVLMPSWVNRLASSAEGILGSKLVDSLDDMDKRAQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF46</accession>
    <name>F9WF46_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_09060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002104">
        <property type="protein sequence ID" value="CCD15914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09060"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="35633" checksum="31C4246E2285D8F5" modified="2011-10-19" version="1">MADAVEAHHQLMRPLIVRYGCYEVKTVGDSFMIACRGPLAAVQLAGALQRCFLHHDWGTTALDDSYREFELQKAEEDVEYKPPTAHLDPCVYRELWNGLRVRVGIHTGLCDIRLDEVTKGYDYYGSTSNMAARTESIANGGQVLLTRGKHLALGTAEREHVSVTSLGATALRGVPDPVEIYQLDAVPGRTFTALRIGPGCRRSSSGGQLPVSMNVARPAREAALRGRLLSRSRCCSVYVCCPINGGFLCCCLCDGASHCHARIGAPEAMLHMARFRGPSQQSLGVLLALMLSAAASLDPIRSTGVAGLCFAIVLCYFAKCNSELCPSDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF61</accession>
    <name>F9WF61_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002107">
        <property type="protein sequence ID" value="CCD15929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01060"/>
    <dbReference type="OMA" id="HEWHEDS"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="806" mass="92262" checksum="6DEE6DD5898125C4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFE4</accession>
    <name>F9WFE4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 375</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002132">
        <property type="protein sequence ID" value="CCD16012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09830"/>
    <dbReference type="OrthoDB" id="1643824at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="267" mass="30899" checksum="FCB144BF551DCCDB" modified="2011-10-19" version="1">MDGKDDTEKVREMLEGINPVIQEKFKNNPDLSADENARQHYMKLLGWEERVQENKDWDEESKRKAMIGFCQRMPLHLVFLQKPEYRRLKYVVMLQILLLMEVPSYSDRKWFYGLLARLLYSSTDPNTPDDSEDDASDDSEDDASDDSEDDASEDDASDDSEDDASQDEDKEESESSPQSALSRARAAYEKTVKKLSKVEALKKRAEEQRASERYMERLSAKIAQLTEQKDRQVTTVDELETDLALERILQTTVASKTENSQVQFMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH8</accession>
    <name>F9WFH8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 387</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002145">
        <property type="protein sequence ID" value="CCD16050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10180"/>
    <dbReference type="OMA" id="KQFQMED"/>
    <dbReference type="OrthoDB" id="346420at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="504"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="800" mass="90534" checksum="160FBEC4068F3463" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFI8</accession>
    <name>F9WFI8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_10280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002151">
        <property type="protein sequence ID" value="CCD16062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10280"/>
    <dbReference type="OrthoDB" id="1674634at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394733" evidence="5">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="262"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37290" checksum="6B3F5FACA9738CC2" modified="2011-10-19" version="1">MRMKIWIVLLGFVRVIADDNSGKTEYNLEPYRELCSLLKIAVGNWVEVQKRDPSDPLKRALGRTIFGSTDGGSLDDLKGLPADYTKGGAERGNFCGQPYSEPGYFSAPHRWSGHSAPHNLVCLCTKGENGYPVNISENHDTLCGKTSDALGAGTEGWTKSGSGKTQMEATWKEVVTHCLDGEVGKDLQKALKTFTGNLVNKPEMANPNRYQLGYGEPGDVYTCTGSPPRGVCVMYYNSTDPTKPQPWWSDLEKAIKEDEVIQEQKRLQQEEKRKKEEEAARQDSPKAEVPKSTLLTTNNTEESNKDNLTDTIRKFNIKSGTPITPPSTWLLSAAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFV9</accession>
    <name>F9WFV9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_11380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11380"/>
    <dbReference type="OrthoDB" id="1674441at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390319" evidence="5">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="94"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="368" mass="40645" checksum="0A26BC9ACF545931" modified="2011-10-19" version="1">MMSKNIMVFLTAIVMVLRVHSAVEVSKEPIKEYFDLLCNATRAATGVWNTVGDLGVFIDPEEEARLTQVFDEIFFGLKCGRFSRGSLIFPEQCVEEDPNRDIVCATKNASKEMPSASESLASAFFCLCIGDGVGDKDFCGLNVKNSLSWPVGEKQKVKEVFEEVWGRYPEGGVMKTCGNFDEDVNLKEETENLTVNIERLKTTLEQKGGILSKNGATCKGSNTCAYITKTPLWLVNLVKFEQTAKYTLFEALKKKNAPKPKSNPIHASSSVSLATGTLESTSPPQPPPPSEPAPVPTPAWSSVQEGTPKAEPRKYSEEKPKPQHEPERKYTESHKYKDDDPLPVLEPNETSGSFIISQKWPLCAALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFW3</accession>
    <name>F9WFW3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11420"/>
    <dbReference type="OrthoDB" id="1729174at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16764" checksum="9CBB7F9DF9EA8D13" modified="2011-10-19" version="1">MLTRVTCSFYERLMQILALKIRFTNNVSQFFQFIGCGLVCFLKFVGPPNQPIPVLIEVSCISFHFLGNVFTMMPFVISATFCLTSNNFTMAHGTPHKASQLKVILLSLIATRLMPLLSLIITTSKIMENLIGRILSLCLRRETEASVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG10</accession>
    <name>F9WG10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_11880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002212">
        <property type="protein sequence ID" value="CCD16240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11880"/>
    <dbReference type="OrthoDB" id="1668234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390292" evidence="8">
        <location>
            <begin position="25"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="95"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="43471" checksum="100CB9B67A048A91" modified="2011-10-19" version="1">MLQAMKAFGVIFMMSLFCSVEVWAGSYSPKFLHTEAGGSICRLSRKLKEVEPWTQEQLEALKKNHDAHASKFLEWQLHFHGSSGGEVNQSILETIRTDLEKVNEEIKKLSAKAIRAGAFAAKSAGRLDEFITVFARARGSGQTFYEKASFCFGYKGDPATRADFHDCFPTGTRFEIEEHNLAKIPESTTGTGEPNLASVIENITHSALSGNWYRYSRDSAAECNLIKGACGGTLKDTQLQNPIWWGGGILTIGNNFNGVLERAKFDAGEIVNASIDSAKAFWTSSPHTIPHLKKTLAAFQDFKDSAAKITQKFAEIDNIEKQIEPCLSNETMEEHTPHKPCFQNAVKLNAELQAANALLARYHKEKGPLPSGSHRTHARYLFTFCYLIATLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG12</accession>
    <name>F9WG12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_11900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002212">
        <property type="protein sequence ID" value="CCD16242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11900"/>
    <dbReference type="OrthoDB" id="1668988at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="47"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="44925" checksum="29E705C796C2A5C9" modified="2011-10-19" version="1">MHKVTNKVEQGLTVMVMELRSKWWWLVASSVFMAWSSAFGEGDTPKAIPTKAGAAICTLSKTLKDVTPWATQQVEEGSAKVTNLEMKLLEWQTKWVQSKAQGKGSETCKMTGLLFRQVRKEIDKVREEVERLEREASKAAAFAANSAGRLDEFITVFANAKGESNGFCLGDTNAAKPEDLRDCFSKTDFSEESLVDIGERASAQEPNLFSRIESIKYSFLSSHFTAGSGGGCNLVKGASGGILGKTDLEKSLWWGGGILTIGKAFDGVLNRENFTAGEIRNAENGGSKAFWTADPATQIVHLKNTSDAFKAFKAVKEKIQEKVKSIEDKMEGCLTGQEPGQNKTEPNATEPTTTTEETPNSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPTTRFLGLLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGC4</accession>
    <name>F9WGC4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002257">
        <property type="protein sequence ID" value="CCD16358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="14919" checksum="648036BEBACB83BE" modified="2011-10-19" version="1">MMEASPSQLLAVLRGTLPAHRRTGRPILHVVGFVWCLCLHHSCVRGLAAGHVQLGRKSYRELRPFQVATGHPPIKVRDLRATVDVPKDVDGPNYKVTEKLDRRKALASGGPHAAVVVVSGHCSSTCHVRIPNDRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF2</accession>
    <name>F9WGF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002266">
        <property type="protein sequence ID" value="CCD16388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13120"/>
    <dbReference type="OrthoDB" id="1672177at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389112" evidence="5">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38199" checksum="3FA2CFF95424C015" modified="2011-10-19" version="1">MMKVLFFVIVVILGVANVSGEKKNDHNHDAHKALCDVMKAAVGRWGDGGQHLSPSLKQALGKTLFGSEEGKGSVETLRSKLPNDYDTEVKEPGSRFLLCGHQPEVVIRKKQTRWPGHSAPHDLLCLCTPGDGGWPLNNGKAEKLCGKEKGALRGEKNEGWSGSKGKGKDQMTATWTNITRECLQGDEKAGDLQKALGDFMEKLKPKLTGVPKSMYQLGEGDSDQYPCSGIKETGICVMYHNNTSPMPWWTNLKNLLDEEEAKKLEQHEKQQRQSEAPKQKTTQKKENQQFPQEPRSAALRSTTPSTEEVEQINPENISAPLATLEDTSGTLLIQPSSWLLFAVVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH5</accession>
    <name>F9WGH5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_13350</name>
        <name evidence="10" type="ORF">TCIL3000_0_21670</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002272">
        <property type="protein sequence ID" value="CCD16411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002679">
        <property type="protein sequence ID" value="CCD17341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21670"/>
    <dbReference type="OMA" id="KPPYAFF"/>
    <dbReference type="OrthoDB" id="1534092at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011938817" description="V-type proton ATPase proteolipid subunit" evidence="7">
        <location>
            <begin position="16"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="8">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="8">
        <location>
            <begin position="121"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD17341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="20087" checksum="732D968899C91187" modified="2011-10-19" version="1">MKYLLVATCFATVSAIAFTNTTKKEACLARLYPQSAGFYGSLGVAVALVFANLGSAYGAAKSGVGLAHLGLLSPEKIMRGIVPVVMAGILGIYGLIVAVIINNNIKTDPYSYSTFSANLHMGAGMAAGLASLAAGLSIGVVGDTATRAYGKQDQVFVAMVLMLIFSEALGLYGLIIALLMNNQANRYTGMCDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGM2</accession>
    <name>F9WGM2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13790</name>
        <name evidence="1" type="ORF">TCIL3000_1_960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575314">
        <property type="protein sequence ID" value="CCC89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002290">
        <property type="protein sequence ID" value="CCD16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13790"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_1_960"/>
    <dbReference type="OMA" id="IHQPHFM"/>
    <dbReference type="OrthoDB" id="974904at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="271" mass="30821" checksum="D692036DC119BC24" modified="2011-10-19" version="1">MQRDVYASLIKKRHKEMVPLLIHQVSGDITRENIFDEVFHGYKLRRIVLMTHMAATPAMSPRLPRDVIVQDFAKLKSIHQPHFHYKLLPLLCTDFEAFAALQGICASANSPFTIEDRTDPQGLTHRLSNGCAERQALCDFFEPHIPEAERLVPVFSRKLPINAVCFDGLLLTRARNNRVAALLTVHDVASEKCIVQRAIMRDFFVSPLYTKVSGNTEVAQALRLVRECTHFMAFKQPLGVGSAARRAILQIAAEKKLFLYEKNGDEYHFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH25</accession>
    <name>F9WH25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 584</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002363">
        <property type="protein sequence ID" value="CCD16614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15240"/>
    <dbReference type="OMA" id="PAHIFRE"/>
    <dbReference type="OrthoDB" id="1455947at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="SSF81382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26603" checksum="655BDA1038F923DA" modified="2011-10-19" version="1">MASDFSAEPLLPCFTARRHGEEALKPDPGHVTICLKDGVVFQSPAHIFREGCLAATEILENKCVNSLEKDAEGSLHLPLPSVDSKVFETVAIYLENFYGSFPSDERDGDIVRPTRLSCPLEHRELYELSEWEHRFVVQRLLELSKDNWQLSEGGRWVDKVADVGVASEMKVNVHNLLLVLDAASTLDIPPLRHLCAAVYANLLLDLGEREILGLMGVEGQLGQEEEEALLRDYPWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH42</accession>
    <name>F9WH42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002371">
        <property type="protein sequence ID" value="CCD16631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15400"/>
    <dbReference type="OMA" id="RWINAMV"/>
    <dbReference type="OrthoDB" id="839593at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="348" mass="37256" checksum="F3203C464230C95E" modified="2011-10-19" version="1">MNGMCHVLTHRHRTNRLPASLLYNNLTLIDECAVIVYASHNNCAVVDLSNQKVHLLPLEAVDEPIVHCTATFLPCGGANEGPEILILLTTQSSTQLWTPTRPLSVVSHGGVHGNGSCGAIAPASTRGVNIILGTSKGVVMFAAYHAKRPATKQRENSSENTSPIFRVVSAVKGHKDNAVTAVQVNRYYNSPLLAVSGDVAGQLLLWSHDQQPFVSISTLECVTAVQIVSGGDYVVAANGAGRLIMLDSHTGSTCIDVCAHSRWIYTLSYHPMCNVLLSGAEDGYVILWLTPAHGSQNVTEFRPTAAHHMQNALPTGAAVSADASQVFITVYDMDGVHQYKITNSKKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH48</accession>
    <name>F9WH48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002373">
        <property type="protein sequence ID" value="CCD16637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15460"/>
    <dbReference type="OMA" id="VYNERWH"/>
    <dbReference type="OrthoDB" id="1654901at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="803" mass="90976" checksum="B30533DDF49701F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH59</accession>
    <name>F9WH59_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 597</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002378">
        <property type="protein sequence ID" value="CCD16648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15560"/>
    <dbReference type="OMA" id="SELLWVY"/>
    <dbReference type="OrthoDB" id="237875at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="SSF117281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2551" mass="276129" checksum="9373FE70434AAD29" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH84</accession>
    <name>F9WH84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 613</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002395">
        <property type="protein sequence ID" value="CCD16673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15800"/>
    <dbReference type="OrthoDB" id="1723864at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17084" checksum="A0C187124C92AEB1" modified="2011-10-19" version="1">MHCGETLLPFAFHWAMRTLECVVHREGEHHRLVFHLSCGMRACASQAGAIVLVCAAASCTHKVSSFLRFHVPVCSSTFPRPLPIHIHLCLLYTLPVSVFYSFCSFSLYGKVGTTALATATLRGLDVSLACDESTFCNDTLCHLWGTCFRMVASVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI6</accession>
    <name>F9WHI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002440">
        <property type="protein sequence ID" value="CCD16779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1733847at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15794" checksum="920C3E4AA3097565" modified="2011-10-19" version="1">MLNTKEAPQHNVEQCRRWVRPGRKPMGRNKKPPAHLKNGTVKVYNSSPPPRPQLGPLGWGCRNGVVCPVQLPVRALPALIAPPQCTQSCFDHLRLALHPSLYSSHSICTPHYPSACIYRMTASPTLRSLLFVFFSCNFSHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHP0</accession>
    <name>F9WHP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002465">
        <property type="protein sequence ID" value="CCD16834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13561" checksum="8D838C3422F68288" modified="2011-10-19" version="1">MQHHRHSGVNEVGRILPCMCGRATLDARRLLLLVSEDIERNPGPMICGAQWNAGGLSRAKLIALERKLHEDIVLFCLLQETHLASAECAALKISGFQHVGQARTPHGGGVSLLVRDGVGWKWAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHQ8</accession>
    <name>F9WHQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_01940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002475">
        <property type="protein sequence ID" value="CCD16852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01940"/>
    <dbReference type="OrthoDB" id="1223767at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="139"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="544" mass="61158" checksum="C24C14DFFF35C7E1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW5</accession>
    <name>F9WHW5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_17930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002491">
        <property type="protein sequence ID" value="CCD16910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17930"/>
    <dbReference type="OrthoDB" id="235288at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36510" checksum="03FA056CF186A2C5" modified="2011-10-19" version="1">MFSFVFMLKLSAFFSFFFLRQKVFLIIFPHLILLYIIACDLSVLRYMLISFLSILLLLYDVDGGGKFSAWDHTKKRTMPGMRLDFLNNVSQRAATGRSMPLHQVEAVVLYGKPEQRGKVIQKVLANAYALCLNKTTHYLLHTVLERCDNNIGVQVLFQLRRKIVDLSHSPVGNIIVQEMIDKLPVRQKKEIAEMFVLNTEEDEFRQLCQHPFGNRVAQKIIENSITCEIVEERLVPFLWHLAVHPHGQRAVASYIDSTEEGWRQVCKAILGLSENVLEEGGSQTSKVAENAKEGCSSEGKSDEYALIKQVSRLFRANTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI74</accession>
    <name>F9WI74_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 740</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_18810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002537">
        <property type="protein sequence ID" value="CCD17019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18810"/>
    <dbReference type="OMA" id="INCREIM"/>
    <dbReference type="OrthoDB" id="1565012at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="272" mass="29672" checksum="12A15A6593D6D6DD" modified="2011-10-19" version="1">MSQGSARRGSGTTASTRGATATVSTGVRTRVKQPPLFVPLRRFATTETITYLVCHITCLILIMFTTGDELFISRERWLSFGRKTQPQHQFRTAEDVYDYFRAEKSAVAKTKLLPRQLGSDLVLSLLLVFTLNGFFLSLVRTIISVVKERGSQGNAEGSPPRAEVDEKASCESNGGKTGLHKLVNCHEFIYKTAVGAALTVCIVISHGILAQPASEVRGAALIVLLSTLTVPICYGDIPGGPKKLEKFFNMYQLIIVVFFVCLAVDANVLSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIR0</accession>
    <name>F9WIR0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_11_8550</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20450</name>
        <name evidence="1" type="ORF">TCIL3000_11_8550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002628">
        <property type="protein sequence ID" value="CCD17208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.8550"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20450"/>
    <dbReference type="OMA" id="QRVRGRW"/>
    <dbReference type="OrthoDB" id="1236730at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC95401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="22111" checksum="9F4A752C92DE9514" modified="2011-10-19" version="1">MFSLTSPLHRKSVQSYPVPPKVRCFSRRWSGCRTNPYNRQYWRVIMNENHTRPSFWVSDFRHRYLMRTGTDFQGQVPSSPQPGLYQGFSDVHKLLANHPKPQRESRHLPVLPLTPRIVYEHANEKRIDTAKKMRRDRRRIEELKTQEFWGWYMKLQRVRGRWCREQGISSRGVYGPAVDAAELWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI0</accession>
    <name>F9WJI0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002728">
        <property type="protein sequence ID" value="CCD17485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23030"/>
    <dbReference type="OMA" id="QWALEFH"/>
    <dbReference type="OrthoDB" id="414750at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="533" mass="58897" checksum="EB005B0251BD3EF6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJN8</accession>
    <name>F9WJN8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002750">
        <property type="protein sequence ID" value="CCD17545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23590"/>
    <dbReference type="OrthoDB" id="909507at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="35771" checksum="5C18D3DE5A8C4223" modified="2011-10-19" version="1">MHKTVCNSSRVIEKIRIIITETFWNDLAERKGVSAMILESLMARLIMASGVLGIDLFNYHFCIKTIRRHLNVLIQTRWDYPITLQQSTIRTLKRWVFHCLANKPQHPMRPYDIHSTYFRRYTICTDASMSGWGGIVYDNHTGGLSTYGGHWRRRTPSADIAELEALALLHTWKSWRVTLDPSFRRLSLAHVDEDSPTRDVVDGVPLEPTIHIRFMVDSTVLFWALTKRASRNHLVWRAIRPLLRNIATLATKTTITYTTSYVNSSNNSADELSRLRPLDTGKVYRSIIANNELGKEPVGMTWLDERYNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJT0</accession>
    <name>F9WJT0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002765">
        <property type="protein sequence ID" value="CCD17588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23970"/>
    <dbReference type="OrthoDB" id="1666276at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394830" evidence="2">
        <location>
            <begin position="29"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="394" mass="44451" checksum="5874DD766006343D" modified="2011-10-19" version="1">MWEQRRMGNGIMAMVVSSIFMCINCVRGGDVSDYKPGHNFNGAEHDVLCEVLKASAELWDASRNSEMKLDRGLESNLRQALFGTFNKRNTERITEALPNDYKNPILWHRGTRCGGCQKRERYYYPGSSITHDLMCLCVPGYYSDPFYYWIFGYIYRETGFKLCGRKRADMVKDQYRGWYTKGGYSEAKSLEKPWETVVWGCFNSRNKSVLQRNQDLAGKLANLVVTMQNFTAILQQSGVHDRLGGFEGDHTASDGNDERSIHVLYDTCNGKRKPWWKKLNETLVMKEAAQLLVTRSSASASLLFPEEGTNPEEEGEDEVEGDLDQPGPQNKAVETTIKSANDTQAQGHTNSTNSTVGMLNTTASGNSTYPRLEYLRSSSHINKPLLSFTAISLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJV8</accession>
    <name>F9WJV8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_24220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002777">
        <property type="protein sequence ID" value="CCD17616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24220"/>
    <dbReference type="OMA" id="YLNGGIR"/>
    <dbReference type="OrthoDB" id="727241at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="2">
        <location>
            <begin position="397"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="447" mass="47307" checksum="97B836EB0322AEFB" modified="2011-10-19" version="1">MDGRLGSYLRALEPKVVGAVSALLHAQGWLSSHLCQEGQSANEGEEQKNDLTTHPMSDGVVVQESQTAVVADCVAKLLDAVSALSNVLPSIESMTYQLASNGALCSIDRRLADCLKQQRSSLHFFLQELELKGRLVDALKATGELPASSAAGEVPLIRALVIALDERIETLLAISDFSGNDTPPPSPGLISADQRAVSGLHSAAAAPSTTPEPPASFLPQAQSQSVNGGQSVTDPEWPKLQSPPSPLKTSRTVEARVRHKFGAMGGRLEASGDGTHLHRLPLPSVVDIMSRSALGALSHHSAPGAQQTSSASPFVSPPAHCFAYTIRISTRCDNVLMGFADSQLPLEVFPPAMNSVSYTGCYYLHLGRGTLYCPRLSIADVPYPDFARSGPVSVCEEVSCELDIGARTIKFTRGGTDCGVAFEDVDVSQPLFPAFEFNSAGGAIEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY1</accession>
    <name>F9WJY1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002786">
        <property type="protein sequence ID" value="CCD17641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="286655at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14487" checksum="D9944CE9D87D3C32" modified="2011-10-19" version="1">MLYDVVDSSQRGVEALEEGIDAYDTPPRARQWLSSAFSTGAKLFAAWLTVDGPREVLSVCTSTCVNFYWMAWNCILWQLQEIWKSLPSSWPCALDRGCVSGEEMRFASDVMHDYCKGHSPGHKCRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJZ1</accession>
    <name>F9WJZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 969</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002791">
        <property type="protein sequence ID" value="CCD17652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24560"/>
    <dbReference type="OMA" id="EANYASH"/>
    <dbReference type="OrthoDB" id="1016066at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040193">
        <property type="entry name" value="EFHC1/EFHC2/EFHB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12086">
        <property type="entry name" value="PTHR12086"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="412" mass="45858" checksum="C94676749852A9A2" modified="2011-10-19" version="1">MSSPLSSVHDNSLGGTRTRLHVAPQIVPAGYRDKSCDESMKTITSGYSSGRTTPELQRIYQRYGEVGRTRRHYGRARDPPLDESIRHGARTEVGEGARRCLQPETGGRMMALMEQQLENAYLSNVRRPLGTLPAAPYQIKVPHCGFGIPTEKSESVKTLLYAGRDVDVLHPVGERKRYGYNWESTGINPTQHRFGYSEGRGDVTVKDVMTETNLVTKLLPKLMTDMRMLTRREVGKGLPFAGNNVYFEETLKNRQMLRSCKAEGDQVRELLSSWMHHPNPRHPPSTKPEGTTVSEGALETANGDTAANDALRSRFLCTFREGATNAPPDATKLDDNVRAHHLLYPCHYVNMGVSSSYFAGGCTLEDVRQLCRKIGMNLTDNQMEEVFGIVAVDGTCGIEQFKNKAVEMGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK11</accession>
    <name>F9WK11_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_02660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02660"/>
    <dbReference type="OMA" id="IMIASWS"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="72"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="472" mass="51455" checksum="F7AC2A5B149A6841" modified="2011-10-19" version="1">MNVELTEKEPIDRKLGESAERRNVNDTQNLTGDVLTTPAAEEGATATNQKEAEDGAPKGPFQQCVHRVLPRGGALSGIFNLSSVTLGAGILSIPSAFNTSGMVMAIIYLVLVTFLTVFSIFLLAAVAERTGYRSFEAAARNLLGPRADVAVGFLLWMLCFGGASGYIVAIGDVLRGMFSHESVPDYLKTNSGRRLMTSCIWLLFMFPLVLPKRVNSLRYASAVGVTFILFFVCVVVHSAQKMVADGGIKQELVMFRSGNNAVAGLSLFIFAYLCHVNTFSIFFEMRKRSVARMTRDAAVSCTFCCCVYLLTGFFGYAEFGQAVDGSILKMYDPYANPIFFVCFVGIIIKLCAGFSLNMLACRTALFQVMQWDLDTMSYVRHSIISVSFATGALVLGLFVPDINVVFGLVGAFCGGFIGFIFPAMFIMYAGGWRLETVGWTQFLLTYALLISGVIAIVFGTSASIYSTILRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK67</accession>
    <name>F9WK67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_25120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002818">
        <property type="protein sequence ID" value="CCD17728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25120"/>
    <dbReference type="OMA" id="VFNMLLY"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390517" evidence="2">
        <location>
            <begin position="46"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="3">
        <location>
            <begin position="89"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="771" mass="85281" checksum="9AA9BA65D05E8052" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W442</accession>
    <name>F9W442_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14786" checksum="A0910E20B7CDB0FA" modified="2011-10-19" version="1">MVGMLVVIRRATQRAMGMGRREDTQALEVLFTVQGHSEKVLNKTGMEEEPQNGALYGRRNRVRQIEDGNVTREEGCHHQTREQLFCTYYKGDPYGCFTKRLPGDVGCAFSPWRGGPFETLFRLDGLPACGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W470</accession>
    <name>F9W470_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000522">
        <property type="protein sequence ID" value="CCD11958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28920"/>
    <dbReference type="OrthoDB" id="1773234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15630" checksum="394338A8DD3AA9EE" modified="2011-10-19" version="1" fragment="single">RIVKGSVRLPSSTGTVLPTFRWEISLRSRCSRSRRCTAMASPQSFDTFTKLLAEQADNWEEEEEEDADEELRPVNDDAELSSPLLLPEEVAASLDDEREPILCTYLQLNLPVQSGYSCSNFPSLGTVLHLARNRSWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4D6</accession>
    <name>F9W4D6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000545">
        <property type="protein sequence ID" value="CCD12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29470"/>
    <dbReference type="OrthoDB" id="1714059at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17994" checksum="F9CEB5F85529A5E8" modified="2011-10-19" version="1">MSPLNCWCIIITFYRIEKHYHDGLVQDASGDDINLDTVRPTSPVFGCPEALFLHDIKAAEHTFLQDIQPFERGYHNLLTPLGILDGSGWSLNRRGEHCAAVTSNRSSFKFLTEDIHETHVLPGFACIPKTLFRITVIAHHSEGRPPAYPVSFPLRLPITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4T0</accession>
    <name>F9W4T0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1223</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000600">
        <property type="protein sequence ID" value="CCD12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30840"/>
    <dbReference type="OrthoDB" id="1698502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="24998" checksum="5652FA485711F4BA" modified="2011-10-19" version="1">MSRKRRRIGRHMEAEKGRYFVRARCGSAYKHNSTRLRGTRAHAIRKMKDESMVITLTMRHTLQCWHGPMKCEREQCLTTMHLQAKHRQPRKEVEHNALKAMRQESSAHMLVRPSLLLLRQRHDLECLKEEQVYRSEPLARSLADLFKLKGFHDPTSYSLVEKRTQAMKRGRWPDLLYSPSPLRSRWQYRWFPIKTGKKYPPIASRPFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z6</accession>
    <name>F9W4Z6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_31440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000635">
        <property type="protein sequence ID" value="CCD12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31440"/>
    <dbReference type="OMA" id="SVMEMDS"/>
    <dbReference type="OrthoDB" id="1541458at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin_tail_1" evidence="3">
        <location>
            <begin position="223"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="640" mass="68804" checksum="8315A5025BF6EFDB" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W582</accession>
    <name>F9W582_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 128</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_03290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000672">
        <property type="protein sequence ID" value="CCD12330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="SCGVRFY"/>
    <dbReference type="OrthoDB" id="2964at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="4013"/>
            <end position="4348"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="4313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="4356" mass="485533" checksum="45ECB3C1C9880008" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9W599</accession>
    <name>F9W599_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_03350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000683">
        <property type="protein sequence ID" value="CCD12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03350"/>
    <dbReference type="OMA" id="EHGINKE"/>
    <dbReference type="OrthoDB" id="687389at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="48"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="251"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="447" mass="50128" checksum="0C5E1C0FE4F6BA61" modified="2011-10-19" version="1">MPREIITLQVGQCGNQVGSEFWRQLCAEHGIRHDGVVEPYASGGDDRKDVFFYQADDDHYIPRALLVDLEPRVINAIQRGSMQRLFNPENVYIHSEGGGAGNNWAHGYEMGDTVQETLFDMIEREAENSDSLEGFVLTHSIAGGTGSGMGSYLLENLNDRFPKKLIQTYSVFPNQSRGGDSDVIVQPYNSLLAIKRLTLHADCVVVLDNTALNRIATDNLHISSPTVEQMNGLVSTVMAASTATLRYPGYMNNDLMSMLASLIPTPRCHFVCTGYTPTTLDTSNIQSSVQKTSVHDVMRRLLMPKNMMVSTSMKSGCYISLLNLIQGDVDPAQVHRSLERIRERSPNFIPWGPASIQVILSKKSPYIDARHRVSGLVMANHTSISSLFQRTLKQFDLLFNRGVFLEQYKRYGPLKDNLDEFRHSRDVVESLVAEYKACESSDYIRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E3</accession>
    <name>F9W5E3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_03360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000706">
        <property type="protein sequence ID" value="CCD12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03360"/>
    <dbReference type="OMA" id="CHRTSEN"/>
    <dbReference type="OrthoDB" id="907439at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="729"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="802" mass="88614" checksum="7E50BDC77FCC6FA0" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Q0</accession>
    <name>F9W5Q0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_33780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000748">
        <property type="protein sequence ID" value="CCD12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33780"/>
    <dbReference type="OrthoDB" id="1674290at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394703" evidence="5">
        <location>
            <begin position="24"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40033" checksum="ABD87362E01FADE7" modified="2011-10-19" version="1">MKITVKFSVFVVMIVIMALRVQPHVDVETKSDDFDLLCNVTKVMLGLLDTVIDLGAHHDDIHEKESDISNKIDEIFFGSRCAAGTQGILILPEQFTKNLPSRKEVCGSTQTSTSEGMPTASESLATVFLCLCTPTSLDVKNLCELEVDAEGTWLDGGKQNIREVFEDVWDQGSEKGLMKRCVNSPTDVGLEEAKGSLTENIERLAIALKQKEILGERKPSCDGSTPCANITAYPIWFENLKKFEEYTKGIKVNRPLVHKESKPQISEITTTSPTPHATPPPTPPAPLHAPVSTQAHDEPQKQEARKSTADDPEQTTEPEPKKTHDTPAKLAEKTEELLPAPEPNETSTSIINTTTWPLLVALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Q9</accession>
    <name>F9W5Q9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000752">
        <property type="protein sequence ID" value="CCD12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33840"/>
    <dbReference type="OMA" id="CITNIAT"/>
    <dbReference type="OrthoDB" id="1282076at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="854" mass="93439" checksum="98AD0A326038A090" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Z7</accession>
    <name>F9W5Z7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000805">
        <property type="protein sequence ID" value="CCD12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34660"/>
    <dbReference type="OrthoDB" id="1574535at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="271" mass="30387" checksum="FAE6151A1ADC6C90" modified="2011-10-19" version="1">MSVRASGVRAPEDVLSGSDVMGVRRKRKHCEGPQPYLGALPRQHKGPPPAYECTHHIFHPVETLRPNISGGSSVSSTTAAAVSAGDGNGASLSMSHGANEESRTLAPEGADTMRLDELQQLLRRFIELEFNDKCRKRSIALIITVCDVLCTNSIAVVKTMEAINESFDGAVQKQEPRLLWNYWYMLDGVLKHFARKPELKKAASVSIPHFVRKYLPWRGSALEKQEWIELENYRVSYENMLGTWENVLEQEEFGEIMTLWRSGATNQTAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W687</accession>
    <name>F9W687_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000834">
        <property type="protein sequence ID" value="CCD12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="KFNDRRR"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="16219" checksum="DC494AB8D9B72FBD" modified="2011-10-19" version="1">MEIIDRPLSEIIKEQKIGESLRRNRRGGKGSQQGGRGNRSIGGLRRGDDRRPLSSERRRFRQRRPDGPFRSSRFSYSSRRRFTGRRGAVDYGDSRWSRSVKSISSMRESRLTGAERNERIRSARRREALSRARSRFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W699</accession>
    <name>F9W699_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000841">
        <property type="protein sequence ID" value="CCD12704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16609" checksum="B872FABC8AC139EB" modified="2011-10-19" version="1">MCHINCNIPVGAAAVLSVTRLFTSHRFAVTVEVLDQISENKTKGKVKKVKRVKKNLFPSLAPKSIHKYSYAFRNLILTTQGSSMIKVQQIQMQPHITHMCTQLSSEERNPIDKREPINESRKRENKKKKKVGEKKEERAAHITCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6A7</accession>
    <name>F9W6A7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_35690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000843">
        <property type="protein sequence ID" value="CCD12712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35690"/>
    <dbReference type="OMA" id="HVREDEY"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="41600" checksum="3566F95B255C869A" modified="2011-10-19" version="1">MSLRWAMLLVSIASWYIAITLLLIGPSGLVTRAPPAELTRNYPDWMREALAFTPAAAIRKWQHIDYLLVLGIPSVDMLERQRRRNLQRTTCWQYDGVARRANGFTGAMLPLYVLARHPSNGYAYTDAMRREVLKWSDMIALPMYEGKPSTNKKVGGGGKWGTEAEIGMSRKTFYWFDFALRMFPNASYFAKGDDDMFLRVPQYLADLRSLPRRGLYWGTMDRFTVDGYRFTYAFGALYTLGRDVAERFVSYLPLKSVIDLPYSEKEAHKFKALYLYAEDAMVGITLKRAGYSSKLFHVNEKKCSFHDIHAGALVGPVSPSSVMVHHVKEEDYGALMKRFNDGKVVAPRNLSSSEFSSRRMFMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6B4</accession>
    <name>F9W6B4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000847">
        <property type="protein sequence ID" value="CCD12719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35760"/>
    <dbReference type="OMA" id="IDIHAGY"/>
    <dbReference type="OrthoDB" id="1541458at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="564" mass="61021" checksum="EDC60A8FC13E3D19" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6B9</accession>
    <name>F9W6B9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000847">
        <property type="protein sequence ID" value="CCD12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35810"/>
    <dbReference type="OrthoDB" id="1726537at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="18713" checksum="9F7B14B2F65A5AB3" modified="2011-10-19" version="1">MHVSSLVVPCRESAAGAIAPPPFHTACTYFETSLVLLLVSFSCTAMITLPSGTGEWLAGCVYVCLCGVAGPACRGLSAPNCHVHCFDVVHFHGVCLSGATGASVTFLLLYFLCTVCFFAFLFLISYLHVYFLYCFSFIFYYFLKSNSVLDILSSSRDSSVNTSCERERGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6C3</accession>
    <name>F9W6C3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_35850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UBR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01000847">
        <property type="protein sequence ID" value="CCD12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="12770at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="PTHR21497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="4">
        <location>
            <begin position="163"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="2">
        <location>
            <begin position="163"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="993" mass="111847" checksum="1B6CACCDA44CBF53" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P6</accession>
    <name>F9W6P6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000904">
        <property type="protein sequence ID" value="CCD12853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36940"/>
    <dbReference type="OMA" id="GNTYRES"/>
    <dbReference type="OrthoDB" id="1154369at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="79"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39691" checksum="273E6B2A565C188A" modified="2011-10-19" version="1">MSSSEGISRYVPSNICFLFLFYPSTRSSDQSVIAIVFTVFIYSRHYTVLKNPSCYFCAGKIADPNKDNASFRHKLEETMRVTLCQMVVERSKEANIRKAVEMITAAAKRGSEFVVLPECFNCPYGTKYFAEYAEETRAGCPTFDAMAKVARENSIWIVAGSIPERLDGKLYNSSMVFGPTGELKHIHRKVHLFCINTETLKMNEGEVLSAGSIATPVVFRDELKFGLGICFDIRFPLFSWKYANEGTSFLVYPAAFNMVTGPAHWELAARSRALDNQQFVMMCSPARDTNAEYVAWGHSIIVDPMGKVLAMADERETYVDADIDFDMVKTARNMIPIMSGVRHDLYSLNWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U8</accession>
    <name>F9W6U8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_03720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000939">
        <property type="protein sequence ID" value="CCD12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03720"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394587" evidence="5">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="46"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="37750" checksum="807D6D51F0F15944" modified="2011-10-19" version="1">MWRRVLLVLMVVWTGALAAEKTNEKVFKRLCNITSGVTALMKQSVETKGTLEEALYGGNGGAQFNVDGTFKGGCWWLGGFNHRSTYCSHIQGAHPGLGGTDNHGCFAHSLLGTLFCLCTKGSNRDEDLCGLGSVGNDSRWVSGLPRSDDLFQKVWKKINETCTENKSTADLENLQTAVKEIHGGAKENKVKNGYFTLGGNSTDGVCGGTRQGDACVTYPPKTGSGEQPDIPWAEKILTEIPILKKTIKQQISLQDSSQIDQQGNEGHSDEDPGEQQEGEEEEDEEQYVQNSTPHNPSNKPRTRRKRSTKKQPTEQHAESLKAILHKDDGSYLPQPFWLLSAVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W710</accession>
    <name>F9W710_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000960">
        <property type="protein sequence ID" value="CCD12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37870"/>
    <dbReference type="OrthoDB" id="1571992at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389878" evidence="1">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20141" checksum="8C055973604B008A" modified="2011-10-19" version="1">MTGRGNKPAQAAATTKLLWLFLFLCGSTPAMADGTGSLSLAGSVATLPEVHRFVEVQVIDGVTGAVVGSMPLDATLTFTFHAVPKTVSEVRLFPRLPLHRFRLNTSASVLRTPVRAEDGGSGWLHLSAVVEELKELSSHDQTEGNLATAATAMVVVALIAIGRYRLLSLFQLPAFKPPKPQKIAVSVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W734</accession>
    <name>F9W734_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1557</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_38110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000971">
        <property type="protein sequence ID" value="CCD12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38110"/>
    <dbReference type="OrthoDB" id="674800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="443" mass="48944" checksum="EB4587B274EE4CE4" modified="2011-10-19" version="1">MALGLSSSAEVYVYVTCIFLGVSILLPSSTRYSAPMFMVNYYKYVTGDENAEPNSVLFWANILTFYTVISLVTQSFVGPTVLTQTVRRLSLSLRFTLSITLMMVEVFVVLMLPVIKVSQTVAIVFFVIVTIVGGIGKCYLEATCYTLVAPLPPKFMSTIMFGISICGVLTSTMQCIIKVSMENTYDSQLTQSYIYFSLSLLIMAVALVMVLSLRYNSYAQEYVAEFRVLTQKQEDEGVEPQPVADVPTEVKESTSCEDKCDVDSKEEGCITTAEQLSPTPIMPVVRIIRVMLISCFLGFFLTIFIFPSFGIPIDRVDDWFSTIAALIFNVGKSIGSFSTSSEMFMHPRGVALYWSIVRFLLIIPFMLSIYKHITGHVVPYIFSFILGLTHQVSVLSMVYGPITTGLNDGQKLIEGQLIGIALLVGASAASVAAMVVVIFLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W761</accession>
    <name>F9W761_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_02750</name>
        <name evidence="3" type="ORF">TCIL3000_0_38420</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="15188" checksum="95271BE3462A3CCC" modified="2011-10-19" version="1">MPLFPSFSHPFPQPQWRKAQHTQEGRKAMDLRVEPAADPEEGSLPTGAVTGTPGAQGEELKPGGGQHHGDAKEGGTRTLASCITTLIPPGGMVSTVFNLSSICIGAGILGLPAAANSGGLIMAFIYPLIIVMVFVQSLYCIAAQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W782</accession>
    <name>F9W782_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1578</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_38630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000994">
        <property type="protein sequence ID" value="CCD13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38630"/>
    <dbReference type="OrthoDB" id="1670097at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394732" evidence="3">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="44699" checksum="460870AFA28ED15D" modified="2011-10-19" version="1">MPRLMTHSLTALLMGCALLLFLNSSPVFAQESNATEEDVESSSVPTKTDEEKVFIRNVTCEADIYASRALCAFPRLMKEVEQERHVAGDNIKGDVENKAQKAHDAAEALRGAISLAKDTLNDPEGKLVKVADNLEEISKEDLGLVQTMVDEANKASEEVGELYKEASKRTPGEGKCSGESGIKSFYGCGDLKGIRFSNYSDGCGPLGMDNLLGHVGPLACKKTPNCHGALRNGLLLTLYVREWDYTRPLVKDECTDKDEWLKDIEDVGRAMKDLGNKINDFNATLSKIDKYIDVVVKITEMVKDGKSYEDILKAVEGMKSASDGSSSMLKTGSEEDPFNISELMNGRETFWGKYSIWIMAGAGSAVGLLLLVTLLFVCCRRRASRKGDGDATTGAAPTGKGTYADPYNPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7C3</accession>
    <name>F9W7C3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16711" checksum="4D2AEEFB8724B940" modified="2011-10-19" version="1">MPSLLSSLSSLIPLSHPSILDRDSHVMVYHHLPQDHSLEHGKGCRGSTLRWCHLPRPRQPLLVPQTRVSRPHGGPRLFYPPRLCKEPSTLHTRSECVRRYMAVPSLSVVKFRQSATPLVKHFGPTQTWKKCTGIREKFTMTWTTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7I7</accession>
    <name>F9W7I7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1619</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_39320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001041">
        <property type="protein sequence ID" value="CCD13153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39320"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389905" evidence="5">
        <location>
            <begin position="24"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="89"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="458" mass="51725" checksum="63486DAAFE804C05" modified="2011-10-19" version="1" fragment="single">MMVMKSVLVVMMTFLGLMGNTEMQQYNAEEFKHLCKILKVAEGEPEKIPDELGKFMETRNALEKLLRATKTSTKTYQKVIKMKSADNEDAEFISYTVKRRIAYEKIQHAMEKAKDIYNRMEEELIQASRERALARNSLAHAIYGVQVGELPKDEDISIMLQNVSRGSIFNARGGHENVSIFSYPEGPTCGWSGSSGPGFTLINDFYCLCVGRDSNHTPCHEDIKGPGWWKSDGIDWNVEKEYDCKKCKDGNCSCCNGSPCCNGGKCEGDKGKCYCPFECDSDEWKEFQTCCKNIGNFNYQGDCDNFNCENCNCKECAEKYGYEDCKEMCEEAREACKACKQCRKGPFGYLTGEWMNMTDGKNKAMELPDGWPHIRRVCGEAFKDKINTTAESIQEVLDEFNKLLGSNKKSEIESDSAESEAHRLFVLGHAKNMVFGIGCHGAHKHNQQGDSGLCINYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7X0</accession>
    <name>F9W7X0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1667</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_40600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001094">
        <property type="protein sequence ID" value="CCD13292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40600"/>
    <dbReference type="OrthoDB" id="314295at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="PTHR14490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1_C" evidence="3">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="27679" checksum="1297B39221A9F22F" modified="2011-10-19" version="1">MEEVRESTTTNPRERIERMMQQQGRKKSDRSDTAEVLHHLQESLQQKEKEYWQLHHESTLDGGSLKTRFKYREVAPENFTLSVEEILAQDDRQLNMLVPMNCYAAYLTPVDNRRDRIKVEKRRRRGFREIDSSRSSRRYGDVSKTALVDPNMEEEEGVKWSQNVRASLRRLHEDANIDSGERRRDNVERNNGVPAAVRVAVAPRGRGEYRQGNEGVGPKKLRPEGKVKLSGGKRRHGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Z7</accession>
    <name>F9W7Z7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_40860</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001109">
        <property type="protein sequence ID" value="CCD13320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40860"/>
    <dbReference type="OMA" id="SAEACIT"/>
    <dbReference type="OrthoDB" id="1014523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="5">
        <location>
            <begin position="14"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="510" mass="53798" checksum="E1F1813B72330540" modified="2011-10-19" version="1">MSFGSFPPQIRRRVAVTGLGAVTPLGLNVPTTWAALCQGKSATRSLECAPFFFPSCIETDRRFTAEEHQKRRQDLLAAMPCKVAATVTTELDSSNLSDGNQNNLSKDKSCRPNFAPTSRETRATRFALHAVEEALVQAGLLKEDAGGNFAACSTSHVDEKSSEKDVSGSVRAANRFSPFYPSERVGVNLGVGMPSLSDVCDAAYYLYADPTRVKYGSVNPLFVPKILGNMLTGLVAVTYGLHGPVSSTVGACATGAQCIGEAAGWIQRDRADIVICGSAEACITPTAIAGFSRMRALCTKYNDRPHEASRPFDKDRAGFVMGEGAGVMILESLEHAQKRGARILAELRGFGVSCDAHDVAAPHPDGYGAKLCIQDALRDGGNVPAGRVGYVNAHATGTIGDDLELRAIDAVLNNNGRGAGRSLPLHVSSVKGGIGHLLGAAGSVEALVAVMALHNQRAPPNINFHEPSAHIPEGIELVQGNTTRDFKSEAVLSTSFGFGGVNTALLFTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W834</accession>
    <name>F9W834_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001128">
        <property type="protein sequence ID" value="CCD13360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41180"/>
    <dbReference type="OrthoDB" id="1827107at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="53" mass="5543" checksum="78A54EC1C100DFC0" modified="2011-10-19" version="1" fragment="single">APAHHVKEYEVCCQAAVRSLVCEGEAWLLLGNLGKAISGTHVMPSLMSPIPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8C3</accession>
    <name>F9W8C3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1727</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001161">
        <property type="protein sequence ID" value="CCD13455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42040"/>
    <dbReference type="OMA" id="ITGHMVQ"/>
    <dbReference type="OrthoDB" id="592768at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="472" mass="51527" checksum="9EDFD7DE8321B117" modified="2011-10-19" version="1">MCDEFLGDLFEEELEKLGKAAFVAGIASFLLKQVVVARSLLRGDPVQNGISAYLPQGYDRSVVAARVGQQLTKSLMVKSLGIGEVKEQLRRAANRDEKVSAFSELFGLTLAGILSGAYVHSLSIMLHVMKHTMCVLVFVLGKQRASAGSGRTGSSLYSKLRSWWNSGTQHFMMQSLLESLGQQMEATPFYFLRDDERTKADDVRQGFCVDALLEIAVPQIVEAAIDVVKTTLKFRDPQMFSVTGCVSENDVHELMQELSVKFLSSGVLPEWTTLLPCSIGDGHSSVLNIYSSLGYSSEDGATPVNGAGAKAAQLTENDSVARSERGSESAMLLNGGHHTEVRDLFQVQASSLPLPTAGTEPCSGAALHEELLNQERVLRQQTATFFREFIQSASFRELCVAHTEELLVVAVAACTDFSSLCSGESAPSSVRVPQVLTLVEKQRLRLFDGDFHVQPYVRLLCEETIRATCRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W941</accession>
    <name>F9W941_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_44390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001257">
        <property type="protein sequence ID" value="CCD13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44390"/>
    <dbReference type="OrthoDB" id="1669240at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005678973" evidence="8">
        <location>
            <begin position="23"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="16"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="43166" checksum="F663E82B39608059" modified="2011-10-19" version="1">MIHRNVLVFFLCLAVLLSVCHAKASTGDATDPFLTLAKARSICSASRTMKGVHSYVSRKITEYQKKYDEMDMIRDVARLKVLMKVNLDAKCGREATFLLYVQEGMIGFRAALEKLRAAGVRAVASAGIAAGRLDEFMSVFKQAHGKNNDNRNCAGKIGSVVDGMKLMLKECYRGATIEDGFHSVADVEAEFGVKDLELEEALKTHLATGDKTTSTSSDATVCNLGTINNSKTYVESGSSENDIKWGDGVLIVKKETGNKYEWTANPTTTIPVIKSAISDFGNFKNAVADIERCYAGLRNDWTDSRLKGADMQRILASLKYNKFNTSEAVSFHVLSSLQTDENNTNVLFPEWNREKVAGKILEEELALCDGKNGVRKFSANWWGIWGFIAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W956</accession>
    <name>F9W956_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 182</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001266">
        <property type="protein sequence ID" value="CCD13746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04790"/>
    <dbReference type="OrthoDB" id="1722793at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20136" checksum="78E9EAFCE5A713D0" modified="2011-10-19" version="1">MTTTKKNKNFIILSPESLNYFYYPSLVSKQRKKYERDTTMHKHHFQINAHPSQNITQQSHILLNQTPHNNIEKITSIIIVIVNLRIVSREQYSVGRVLIMSYRVWFHNRGSLLTHHLITKPTLHGQLLWHTLSITPIRTPSPNQCLLSLTLPPLNGYSSTRGTAFPSNPRTSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9E8</accession>
    <name>F9W9E8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 1854</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_45390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12316"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="EC" id="3.1.3.64"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001302">
        <property type="protein sequence ID" value="CCD13848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45390"/>
    <dbReference type="OMA" id="ARSAWCV"/>
    <dbReference type="OrthoDB" id="824298at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="PTHR10807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="SSF57903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="10">
        <location>
            <begin position="211"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="798"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="447"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="511"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="855" mass="95620" checksum="8B954B63857FF3C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9N8</accession>
    <name>F9W9N8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_46270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001333">
        <property type="protein sequence ID" value="CCD13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46270"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394792" evidence="5">
        <location>
            <begin position="25"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="41187" checksum="534123E34A17601B" modified="2011-10-19" version="1">MWRGNVVLTLVALVLGMFAVLGNSDSGDGNVEEKELLCKVLTAAETILNNKNADGELYKDELQKAIYGDKFRAKFDRTGSVSVGGYCHTKSLRAQHCKYYTEGQRYFWGGGRDGCFSESLVGTFFCACTPGSPKSKVGDLCGVSTSEYQGGWWSSYSWKKTALFQHVWDRVIQKCTNASGNVANILAELKTLKKSVDSVKEKIKRNGKNNNFYYLGGTGQADCNANNVNEICAGYQGKGEGGLNIPWVNKIENVIHEIKKVEKEKERIPRASDTATSPQAENNAAEAARVEENDAAPLLADPIASRNHEQIREEETENQSANKSSIPDEVPKSRVKRTTTNPSLTDIPHIATNPNEGGSFLTRQKWLLFSILSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P6</accession>
    <name>F9W9P6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1883</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46350</name>
        <name evidence="2" type="ORF">TCIL3000_0_58230</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001334">
        <property type="protein sequence ID" value="CCD13950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46350"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58230"/>
    <dbReference type="OrthoDB" id="1707487at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21159" checksum="7CEDF22BB434AD47" modified="2011-10-19" version="1">MSWYTITSTRTIPWSMEKDVVEVLLDGVTSPDHVNLYWFLRPVLACLPVDLVCFTLGDFVRNPRHCIPEVNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPYQGVVLVGATASFIQVPYSTVGYLVHLPVSSRAWPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA44</accession>
    <name>F9WA44_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001387">
        <property type="protein sequence ID" value="CCD14100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47670"/>
    <dbReference type="OrthoDB" id="1703571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="20588" checksum="56F35F2646EE20E2" modified="2011-10-19" version="1">MGHGIISPKTFKPQTFETEKNGGVAREVHLWWVGPFLASVLLLSHQLSEFTETKMPIRKALSCHTVIWCRALVGPPGLSTDPLHPTAPSPVGLWHLSGSCGLRSHPPHTHWRLTTAGQTMARVAGNLHSPGGLLVTSLFSTAVLLSEDSLVGQEESQTYSLKLWSTPSFTIATSFTTSQLGSSLYKPHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA66</accession>
    <name>F9WA66_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001401">
        <property type="protein sequence ID" value="CCD14122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15594" checksum="E42C5CA16104829B" modified="2011-10-19" version="1">MVPLDRFRPCHADTFSRLLPPRIIHHTGILGSSATTIPRGSMVAPYSSKIKKVEPVHGTFSQGLPQVLDYFMQGAHAMVFSRDFSQACHTSLPMQARFSNLAPDVLKEILVVHYGTDRPTAAAGVGTGFANGTGVFRRSSDPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA80</accession>
    <name>F9WA80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1946</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001404">
        <property type="protein sequence ID" value="CCD14136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47960"/>
    <dbReference type="OrthoDB" id="1716384at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="18349" checksum="57C11EED6592D2D3" modified="2011-10-19" version="1">MLYLDKGGQGKGGDWSAAACVETTRVGALQIRFHVLLAGVKFGVGAVLECSERMDSVRGVPMMRPESGGVWCPQSVAVGCIGDFAGAKVLLLNSPPSAFPTIKMLLPYQRDFPSSAPFRIQPFHPSSSCSRGSLSLLNGTLSHGAGCPRCWNPGWVRVHSPFRSYPSNFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAF2</accession>
    <name>F9WAF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_48610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001427">
        <property type="protein sequence ID" value="CCD14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48610"/>
    <dbReference type="OrthoDB" id="1663993at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="107"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="47156" checksum="7D40F8EB1EF209E6" modified="2011-10-19" version="1">MLIKLIREVKNRGLFVNVLLATVVICSWCGYAVGQPGAEVKATDNAEQFALLCRIYNVAKNPPIHHVDLQDPLKIVKEIDVINASLVDPKWLNETDQVENSSGVQLQPTTTREAAVAQALIRRITKKAHNILEEIGNVNTTRDIEKVKSEFDQVIFGEAGSKVGLCHGALKGVGERGNACGISGLQKKGQSAGKNLVVDFFCLCAQRNNEGIQDSCKVKVGSKSDEHSWGSGAPSGSSSMWASIKKECGNLLHQNPKSTKEGHEVLADFFKHLKSGGLHRWGNTKSILGSGRKAGMLGTSAGTEQEKGGDILCDGSKGYAQRNSGKPPGGICVFYGEESEWDNIDWVNKFKNALATLKSTNNKTATIQRDIQKLQMLLHRAEQIYETAKVITEIQNPVVPTNLQTASKRLTAYNAAKRHNPYAHFILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAM3</accession>
    <name>F9WAM3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001454">
        <property type="protein sequence ID" value="CCD14293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05300"/>
    <dbReference type="OMA" id="LWGPRHI"/>
    <dbReference type="OrthoDB" id="1310589at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="22297" checksum="B1D1500ECC6761F1" modified="2011-10-19" version="1">MFICACPLLTEVSLTESAIEITLHVLCFFRCYSFQVMTTDERQLFSKYVEEISRTQRHHVANRVEELARHQSSAWYYFIGCVAFTTSSVMMAFKLWGPRHIFKNSMYYARPLPPAISMGVVLYGILYTCRGMLMRNRICTMMEDYEYELKRISAHHCEEGVNQLAWLQFITEQLKQGAEHRFDFKKLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN7</accession>
    <name>F9WAN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001460">
        <property type="protein sequence ID" value="CCD14308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49420"/>
    <dbReference type="OrthoDB" id="1720764at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="18231" checksum="7D976940CF75A793" modified="2011-10-19" version="1">MKCFRVACKFHSRFSLFAFCCLVPFSLCASFQFYHCFFSFSPLLHCSACFYSFPSLCPFLFFIVLRFVGSPGVPRMGEAKQIKRYLSLNAVLLVSPLLVRYIDIRSPCFFFLFCASSNPRRAVWLISSFCFLSVDCTSEAFSPNIFFLLCNLRRVLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW1</accession>
    <name>F9WAW1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_50010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001489">
        <property type="protein sequence ID" value="CCD14383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50010"/>
    <dbReference type="OrthoDB" id="1676386at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="75"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="377" mass="42003" checksum="3E46DD0A9C1A0CB1" modified="2011-10-19" version="1">MDDELVFRFLNFLSVLIGERQWSRMCIVKYLVSVFIVVVVVRADGAEETSVKKDHNKDEHSVLCDLLNAAVFKWKEIENSDSPLKKALAKTIFGNESGGNLEHLRSLPVDYDELKSRTLPRYYWCGERNQGGGSSGSNPPRRSGHSAPHDLICLCTPGDDGYPVNGSAVTNDMLCGKGAKELEVESDKKGWGIIGQGEKQIKATWEKVVTECLHGSGKGTRLKDALDNFIKKLGPLAQAIHSYQSLGKGNFSSEYSCSGKGIYGVCVKYYPEEKHALPWWKELKKAIEVDEKEQKKHEEAEKRKQEAQKQRQPQKQDQSQYPQGPRTAALRSTMPSSEETEQSSTENISNPLATLEDTSGTIIAQPCPWLLSSILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ1</accession>
    <name>F9WAZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50330"/>
    <dbReference type="OMA" id="TAGEMMA"/>
    <dbReference type="OrthoDB" id="1166702at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="412" mass="44819" checksum="7231318409201B5D" modified="2011-10-19" version="1" fragment="single">MYINKKDAPVGGVIIVAVVTPSKMEGNTNMDSGELLPPHREPNMLDLFMTRYDYDYNHRTSSNSAGKGDPKHVVSGEVRNRPIFRMGTHCGDTATTYRTDYLGYNRGVENFGEILGACCHNERPQTAFASGSRLEHIVGDPSGNELCPNTVYKTDYAYKNRVLSGKPQLYAGAKSTAFNPKLLAIACNGESCSDEITPKITCKESLLGKPHPELEGLPARSDDLLASRRPQLTTGGDPTDYYCTSWAYGDKSLAYPSQLPCGLTDSQNGHLIGTVKDKAELLALLSGKGKMRSKPIPSLPSATNPVTIGMAEQPYCAVTRRMENEGHVKMSIYKSDYINQAVLPELPDAAVLASIQSEGTGDMGLNLSASASSTGKLTNCMHKLGEMRNSHGYIHKECPLQSAIDAQTWKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB13</accession>
    <name>F9WB13_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001517">
        <property type="protein sequence ID" value="CCD14440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50550"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20040" checksum="48D90072786D12B8" modified="2011-10-19" version="1">MSNSPFSPSPEGMAQDKTQWSMEKDVVEVVLKGIGDPEKINLYRFLEPAYPHMHSYVSRFSITDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDGTDPDLMEGMVWAVCRMPPQARGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB19</accession>
    <name>F9WB19_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001519">
        <property type="protein sequence ID" value="CCD14448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50610"/>
    <dbReference type="OMA" id="EMNTAVR"/>
    <dbReference type="OrthoDB" id="146985at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="876"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130910" checksum="81B7B08D1E5BFEE7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBB5</accession>
    <name>F9WBB5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2087</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001560">
        <property type="protein sequence ID" value="CCD14546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51530"/>
    <dbReference type="OMA" id="CEEYIND"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="808" mass="91767" checksum="1E0B96C17286C34D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBI5</accession>
    <name>F9WBI5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001584">
        <property type="protein sequence ID" value="CCD14618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1652998at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13317" checksum="52EB6867DEC4840A" modified="2011-10-19" version="1">MEPTEVSEEEVELRYERAMLLSERDFLRREVDSTASVQARVTTARKGDAEKDSELLRMYLSGLLGGNLQARRKAETNMREKVKAKRAHLVELRRIFGELQKEAMQVRDRCVAYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBN9</accession>
    <name>F9WBN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001603">
        <property type="protein sequence ID" value="CCD14672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52680"/>
    <dbReference type="OMA" id="AVEAYEC"/>
    <dbReference type="OrthoDB" id="1017137at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="486" mass="53801" checksum="5E51642845A5E751" modified="2011-10-19" version="1">MHAAVVTNVGLVVDAVIVARCLDDAELVLRGGSTGAEEHLCEYASQDRTPLVGPTLTRLEGRNASFSGRGDNTVGDGIGIGAGGDCRGCVNSSFTTVSKSILDDNVHYECRAVKKPLPQRIFHHFDVLPFGMACPSAVFSVLGRHTNRGLVVGLTHGGIFVVRPYPLGEPLKLVPRGADRKQLREEDILAISVASRSPIVKEEISKFIRCADHYAQAEKYKANICRDYCASSSSSDASVNDSNAKATNAYEDIEYYALKDLQLPPMLAIHDPIPPLRVGSRVIARRCCCIDTLHIARVCKVNYNVTYTLQYEADGAIERGVLHNDVHLLDEQGAEHCSVRDQVTVVLYDQEPALIIECCGDEKYGVVLDHNPGQAVYVNRSNIVFIAPLLKDALYSDPVILQWFRDLDPMNTGVVEWKDVRHLILGFEGYGAKLEFKKIGEIQRDLCLRVGQVNSQMLRSIPVQTEEMKLHYSEFEYVILRAKNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBR2</accession>
    <name>F9WBR2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_52900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001617">
        <property type="protein sequence ID" value="CCD14696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52900"/>
    <dbReference type="OMA" id="GIYSFEG"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="72"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="473" mass="51554" checksum="AE813FF337A597B0" modified="2011-10-19" version="1">MNVELTEKEPIDRKLGESAERRNVNDTQNLTGDVLTTPAAEEGATATNQKEAEDGAPKGPFQQCVHRVLPRGGALSGIFNLSSVTLGAGILSIPSAFNTSGMVMAIIYLVLVTFLTVFSIFLLAAVAQRTGYRSFEAAARNLLGPRADVAVGFLLWMLCFGGASGYIVAIGDVLRGMFSHESVPDYLKTNSGRRLMTSCIWLLFMFPLVLPKRVNSLRYASAVGVTFILFFVVCVVVHSAQKMVADGGIKQELVMFRSGNNAVAGLSLFIFAYLCHVNTFSIFFEMRKRSVARMTRDAAVSCTFCCCVYLLTGFFGYAEFGQAVDGSILKMYDPYANPIFFVCFVGIIIKLCAGFSLNMLACRTALFQVMQWDLDTMSYVRHSIISVSFATGALVLGLFVPDINVVFGLVGAFCGGFIGFIFPAMFIMYAGGWRLETVGWTQFLLTYALLISGVIAIVFGTSASIYSTILRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU4</accession>
    <name>F9WBU4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1887682at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14142" checksum="5E7C40F069FA5F21" modified="2011-10-19" version="1">MKMLPSILAAEHTPARMLLAGLCGMVGGDPMRQAGPMLHWELGLICGTFPLERDGAALRLAWVTASGLGEMAQPRNRNLVPHPHAKDATVVGCGDTPKDAQKRPTQSCEVRCNIGGRRQKDLRDNQRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD9</accession>
    <name>F9WCD9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2218</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_55010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001705">
        <property type="protein sequence ID" value="CCD14932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55010"/>
    <dbReference type="OMA" id="FPRASAC"/>
    <dbReference type="OrthoDB" id="649145at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="24216" checksum="B3FDA5B223206CA5" modified="2011-10-19" version="1">MLVSCDTEDLGCAGGLMDNAFKWIVSSNKHNVFTEQSYPYASKGGNVPPCRMSGKVVGAKIRDHVDLPKDENAIAEWLAKNGPVAIAVDATSFQDYTGGVLTSCISKQLDHGVLLVGYDDTSKPPYWIIKNSWSEKWGEEGYIRIEKGTNQCLMKNYATSAVVHRPVPPPPPPASTFTQEFCEGAECQSGCTKATFPRASACSSAAPVLSSPRAGPITSHRSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ2</accession>
    <name>F9WCJ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001730">
        <property type="protein sequence ID" value="CCD14986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55530"/>
    <dbReference type="OrthoDB" id="1726457at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15749" checksum="DAA4EF42C208C7EE" modified="2011-10-19" version="1">MIYFSFYSNQSGKSKPFQYKTEPLMVSALIPFIAPAAVCWCAFTLGCTFRYNVVGSYFPLTSNVLTGACFILTDSPSKQTDKYPRSSNKCRPYGSHISVPFTRAHPFRYAPHSQLPVKLLLPMDGSAMRRDKWCVALAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS6</accession>
    <name>F9WCS6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001754">
        <property type="protein sequence ID" value="CCD15074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56380"/>
    <dbReference type="OrthoDB" id="1656713at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="669" mass="73818" checksum="DEFB73559E6622E1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT3</accession>
    <name>F9WCT3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2263</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001757">
        <property type="protein sequence ID" value="CCD15081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56440"/>
    <dbReference type="OrthoDB" id="1683488at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="333" mass="34251" checksum="E6BE829F00CD7EBF" modified="2011-10-19" version="1">MGCAQSEVRELCQFQQEVDNINVVGGCPGESVAEACDDSVRHVAPELLGAHVEAPGDSASNEAASMPRGAPALPVSVDQLGSAFGVLDMDGDSGVGSVEAGAVPSQEGGVGEGINAHAAAPHQPTGKGADIPAASEVLFPQSTPPNTPNVRPRPAIACGVLDDDEGVSLSVSSTSSDDAFSIVGRLPTSHINSYLTDTTAPSSEDLALVTISSLSSALTPRMFSGRFLTPVRDSRPACVPAKAGRSSSGGRLRYFGRSCCIPFSSALLAGRERPTRRQRSPLVPMKKCQDNKSPIPRPTPSLATRSASSSGAGSLVSRGLEGCSPIRCATFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCY5</accession>
    <name>F9WCY5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2292</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001789">
        <property type="protein sequence ID" value="CCD15133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56930"/>
    <dbReference type="OrthoDB" id="1720565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17051" checksum="664F2BCEFA2DAB78" modified="2011-10-19" version="1">MLERLHDNTVRDIRYLVGDGIKTLRDWALRGASTSLDHVPRDNLDEAVREARKQPRFSITSGSMSVRSGNEASGKLTHQVAGTTNTQRQPGGTDDSEMREIPRKAFKSWEGVHLVDFFDSGMWEDTRSLQPQCGCRCFPGRPIPLHRKGCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD76</accession>
    <name>F9WD76_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 233</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_05920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001833">
        <property type="protein sequence ID" value="CCD15227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05920"/>
    <dbReference type="OrthoDB" id="364605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="363" mass="39689" checksum="2E0A000168658AEE" modified="2011-10-19" version="1" fragment="single">MNQLGVKRQRQGDEANAIAQGTGPSRSVKAAAAAATTIVVPASLSCSSAVGRGATWGQKTKELQDQIIQLAQLYTAKKRENEEVQDAIEEMIASHDADMIAVVADDGARRQGHLNSLAELRSREEACALEKQRALDQAAELQSQRAALERLKDGLREEIVIQTDSLEQLQGELSAQRELTARERGRLEELAERHRLMQNATYGLSGEVKEIVEELESLAGKKELAGEAAQLVELTRRQLYSQCEEMKGTIRVYCRVKGSEPSVLSSSRLADETVSNSSYFCDVRSQFPSEASQEESASPRGTGSASVGSRQTSDSGPRETGQGERNPLKGYFVFPEGDTEDRRSLCVMLSRKNASLTGRQDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD80</accession>
    <name>F9WD80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001835">
        <property type="protein sequence ID" value="CCD15231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57730"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012429392" evidence="5">
        <location>
            <begin position="16"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="85"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="43871" checksum="AD288714DC84193D" modified="2011-10-19" version="1">MIKLFMVMMIMVVMGSWVREWRVMANAAVSVNEGDNKEPFELLCRIYNVAQYPPIKPVDTKEYQKIVDDINALNAAANGKESVNTQSEETKSAQTQLIGVTRDANKLLDEIKKINPEGQAERARNTFNQVIFGEHGKEGDLSHGALNGVRGRIAACGSNEKGASAGKNLVVDFFCLCGQHTEDSHGVDKVCGVSIGNGKDSRWEGGTLVSPNTMWDEVKHGCATFVKQGVTSTQDGYSLYHQFLDKVKAGGNVKTKKSGVAHKQGMLGTAVSETGTTNFNCNGQKTFPIRAPSGSGRCVIYGEQHLEENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKAESQLEEENTEDSPLAQHPNPDENENTESATQSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDH0</accession>
    <name>F9WDH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001866">
        <property type="protein sequence ID" value="CCD15323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06030"/>
    <dbReference type="OMA" id="NWKEMEN"/>
    <dbReference type="OrthoDB" id="1654756at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="803" mass="91799" checksum="BF71CC12B98AF4E9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ6</accession>
    <name>F9WDJ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001878">
        <property type="protein sequence ID" value="CCD15350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58770"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390215" evidence="5">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="35"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="47964" checksum="3355B50A03D654DE" modified="2011-10-19" version="1">MIRKVTVVWFVYCICMCSGQPSKDEFNLFCRILEKADNMVTEVQDYVYDEWQDRKTVWEMKRLYNATANNMNQLRRTLWDMKKFLQQNPPPMQPRNRQKAHRTVSKLINEVDKIVRENRDVAERVNKKIQEAKLSVLQGLYGENVKDIPLTDGNFTAIQSDEGSIFNNVSTASGSCGNNSAAGKTLFNDIFCVCVGEEGDADGPCSAYILPPKNGKDKGKWTQIKYTSSNSKALPLSESITKIEKACKKHLEENIVDRPKGMKALLKEFVDLIGEGWGKENNNGHIFGHRRRSNKDGNKVKSCDGTTGNQTGGGNKEKNNEKFCIDYKNNFKSENKTYSIPWHNKFQAYFTKMHEAKSLEEKILRSRAEILILKAKAWAAYGQEKEDETANLDDISVTVEYETTHHFPLLYFLTCHFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDX3</accession>
    <name>F9WDX3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TCIL3000_0_59960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL3000</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="CAEQ01001924">
        <property type="protein sequence ID" value="CCD15478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59960"/>
    <dbReference type="OrthoDB" id="1310134at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="PTHR10942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD15478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="29684" checksum="71E0AA90C29D0112" modified="2011-10-19" version="1" fragment="single">MHRSLCPTPHCRSTASIYSPPRLHESTRVRMKENSFTVARALGACVSKWVIFILLSALFLCKAACQDRDHSLNDTAVVVENDTAVNITNASEEDIAVVEGGREKMVNGWTSLRVVVSTNDLDNPKRCCTLSGQERPDFMGGVAPCGEQDVLTTEKRLTLTEYTIPGAIRLHYERLGVSMRMDNIIVPDFLSAVCSSFTVPESHRSVGVSGADVILYVAAGPTGRADYAHTRVCALLPSGRPAVGVINFSPSAISRSRSSLRAAAHEIAHILGFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE46</accession>
    <name>F9WE46_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2438</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001951">
        <property type="protein sequence ID" value="CCD15552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60440"/>
    <dbReference type="OrthoDB" id="163136at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="1">
        <location>
            <begin position="11"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="31968" checksum="5938F97778D5E498" modified="2011-10-19" version="1" fragment="single">MRTGKGRSEGQAFHRRLLSEYNTDFTLDNYVSYFELKPIVKKMEQLQKSIRQFRSAAGDSGAISEANNSLFDQLEMIELPQKNADSIGKHQTLEQQVAQQCELSARFFKELQASFQKVKKYQQRLEADLLLGVEELKHMDEEEIRAHPEELIPRLYVKAQAIMQYRALNLAALRKILKKFMERCACDSLELQRHLKDVDAVISRSTVAQPVHDLRRVALDLIALYGTVFRLTYEGTVESLTRYEYRAGMNIRRILPHSDTFFFTLRLPHQERPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF4</accession>
    <name>F9WEF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002002">
        <property type="protein sequence ID" value="CCD15661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06790"/>
    <dbReference type="OrthoDB" id="1749244at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20874" checksum="3F044306115AB7CF" modified="2011-10-19" version="1" fragment="single">MFLGSKATTTSSDTGQPARHIPQACLYLRSSAGSRPGNTTSVSEGMERKRHQRALDRDCQRHLRNEPWGKMRATTKRRRRKKNRKERSKGPRRPPSAVLTVEAVATHSFFTDSLLFDIYIYIYTRTSLLSLHILSLFFVYFLFHISVFLGFLPFSPTLPLLSVFFFFPLTVXCLLITKDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEY8</accession>
    <name>F9WEY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_08510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002077">
        <property type="protein sequence ID" value="CCD15854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08510"/>
    <dbReference type="OrthoDB" id="1667119at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="94"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="416" mass="46155" checksum="B8B6BEC83CD8F906" modified="2011-10-19" version="1">MTLVLFLLFCQGLERKMMKLFMVMMLVMGGWVRHWRVMANAAVSVNEGDNKEPFELLCKIYNVAQLLPIKPVDTKEFQKIVDDINALSAAANGKERVNTQTEETKSAQTQLTGITHEAHRLLGEIKKVNPEGQAEMARNTFNQVIFGKNGKEDLSHKALEVVPSRMAACGSKPLEKKGQSAGKNLIVDFFCLCAKHDVEDGVDKVCGVSVGNGRDSRWEGGTLDSANTMWDEVKNGCEKFSKHGVTSTQDGYSLYNDFLEKVKVGGNVKVKDSSTTPRHGMLGTAVSETGKNDLNCNGKKEVSSGGRFTSSAAGVCIFYGNHHQEDNIAWLKKFKEGLQLIDKLNTETAAWQHQLTTLLNRARELYEKVKADSQLEEEKTQEPTQAQDPNPDENENADSSTRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF27</accession>
    <name>F9WF27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ecotin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08890</name>
        <name evidence="2" type="ORF">TCIL3000_5_1680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I11 (ecotin) family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002094">
        <property type="protein sequence ID" value="CCD15895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_1680"/>
    <dbReference type="OMA" id="NDAANHQ"/>
    <dbReference type="OrthoDB" id="1512958at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036198">
        <property type="entry name" value="Ecotin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005658">
        <property type="entry name" value="Prot_inh_ecotin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35890">
        <property type="entry name" value="PTHR35890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03974">
        <property type="entry name" value="Ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006865">
        <property type="entry name" value="Prot_inh_ecotin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49772">
        <property type="entry name" value="SSF49772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC90465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18723" checksum="864C8C92BEB1EABA" modified="2011-10-19" version="1">MSRRVSRFRSSVRRCSLSSNVDVDYCKFEEPPSPREGQKRCLFVLDPLEHHVESNDRMLELLPGRVEAVDGVNSYFINGTVTEEVLPGLGYPCYMVDLKETYKSRYAVPPEAIPEKKFLSIRHRKLIPYNSRQPVVVYMPVDADIHYRVWSGGEVKVAMAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF59</accession>
    <name>F9WF59_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_01040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002107">
        <property type="protein sequence ID" value="CCD15927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01040"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="50"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD15927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="44487" checksum="F75F2F7B56ACF3D5" modified="2011-10-19" version="1">MIIIYAGQHTVMHVHYVHILLLSIYLFIRCVISGSVMGMENVIRLLVVSMLVVVYAVANDKAGGGSTITLQKATAVCHIARKLKGVSTYVAQKLEEYDQKIQEIQMMRDVVRLKVFMPGGEKLNCGKESAFLLYVYERLAAMQEVMGKLRQAGTKAAGSAGIAAGRLDEFVSVFKQAAGETSDRSFLNTCYKGSGSQNIFYGIGDDTDTQYGDGVKNLGEYIDAQFTLSGTGTGGSSSNSDTLAHVKNSKAYVDEHAIVHGMPWGDGIFTVQGGDQGEWKAVPSKDVTVLKSAAEDYQVFVSLLKSIHSIYAVIKADWVKNKLVSDNTIRNVLYTIKTTEGQKRRTSEEDDNSPEGPPWFPTWNPSNMRNKLLEDELTLCEEHKRSGTAVVPLPLPLFLCFIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF80</accession>
    <name>F9WF80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 359</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002114">
        <property type="protein sequence ID" value="CCD15948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09340"/>
    <dbReference type="OrthoDB" id="1704336at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="22236" checksum="CA60E3122D1A51CB" modified="2011-10-19" version="1">MPSNSLESSGTGTGIFFTPSKGNIFLQMTPCAESNENESNGTTLKDSLHSGSWGQSSQVPLYVLPVTEDKWLSHIPSVVERRTSRRSSSQLGRAPASSFLNSYTKSSLSSYPPFVAGQGRVGGPASCKTCGAPQYLPAAGPEIPRTEIQTATTDQPSSPASPLQTTIPRLFSNPTPQGFHQRVMEAQKRQMNKLLHNRQPETGGKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA7</accession>
    <name>F9WFA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01180"/>
    <dbReference type="OrthoDB" id="1683977at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="306" mass="33728" checksum="69FA4FD6D14012A8" modified="2011-10-19" version="1">MHHHSVCQCGKLLPHTRARTCLSSCNCLIPLILPHAVAENTTQETMRFFSSAALSFFVLMLHAADVGNAFPAWGRSPICIEGLKLLKGVEDRFSEKLKTYALAINSTESLRAHCERLMEVVGPTADANDVRSRVKALKRFYVEFVKDQSVAAELREEVRRLVQDIKRECGSWIRFILGSWGIKKRLEQKLADGDRMKKELEKHVSKINNMWAAVNSTGCSVEYYDRLLEQYKRKHGPSNGTGGQPAVQEPANANVSSESTESADSGGSTTGGSNGTAGVDGVTGEGSGVPSDSNNDTSRYWSRYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH5</accession>
    <name>F9WFH5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002144">
        <property type="protein sequence ID" value="CCD16047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10150"/>
    <dbReference type="OrthoDB" id="1728302at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17450" checksum="44AE7E576FAA0A44" modified="2011-10-19" version="1">MTEKRKNVPQFCRTCRLATRRRAGKAATLCFGVPLQRAARPDQQAVHTPSTDVLHKVLQGLKKAHESKASQRNFPPTTRTPADITGTPFYYPCVPLGFPKKVSVGRPPHDPHSLEIQMKLQFLPMCAVHVQYVGEAAREWGIRVRTRLGLRNDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFI1</accession>
    <name>F9WFI1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 389</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002147">
        <property type="protein sequence ID" value="CCD16053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10210"/>
    <dbReference type="OMA" id="TSYKAIY"/>
    <dbReference type="OrthoDB" id="1339117at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37606" checksum="7E43D1977F5F09BE" modified="2011-10-19" version="1">MSILNEFVGLLFDVSSPAGTIFVFVFPWFGVLLYYLFFLTKRVKEVPAAVVEPLTHFLDLLTEGASSGYDKRLMNLFHPDLLAAAVHRGVVRAMARCVCTKLGKPVNIPRDTVLVNYDGENNHIIALVDFEKEQQVKCRMTWRDCAGSKDKPPQRGPLSAEVRQQFHVMAFRIEPHKKINFFTEKFLCAEDFIPFAEKFVEQLFDRPPVAAVEMMHPSLREKHIDSIDKLQRDIQLTCGASADDPVNVNHTLVSAKLMCRPASNDDGASQTEEASVGGIEMIFRVSGVGRRDVDVNLFLTFSGLQCTVACYRVAAVPDTRTQVIVDCETGEKTFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK3</accession>
    <name>F9WFK3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_10420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10420"/>
    <dbReference type="OMA" id="IESPWRE"/>
    <dbReference type="OrthoDB" id="288155at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="116"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="774" mass="84895" checksum="6DCAE6154131CF04" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL4</accession>
    <name>F9WFL4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002157">
        <property type="protein sequence ID" value="CCD16090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10530"/>
    <dbReference type="OMA" id="YIFVFVC"/>
    <dbReference type="OrthoDB" id="1683531at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="32754" checksum="594487050864BF4B" modified="2011-10-19" version="1" fragment="single">MALYHLFGQYHSIALYHLIAQYHSIALYHSIALYHLFGLYHPMALYHLFGQYHSIALYHLFGQYHSIALYHLIALYHSIALYHSIAIYHLFGQYHPMALYHLFGQYHSIALYHLFGQYHPIALYHLFGQYHSIALYHSIALYHLFGQYHPMALYHLFGQYHSMALYHLFGQYHSIALYHLIALYHSIALYHSIALYHLFGQYHSIALYHLFGQYHSMALYHLFGQYHSIALYHLFGQYHSITLYHSIAIYHLFGQYHPMALYHLFGQYHSIALYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM3</accession>
    <name>F9WFM3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">WGS project CAEQ00000000 data, annotated contig 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_01290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002163">
        <property type="protein sequence ID" value="CCD16099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01290"/>
    <dbReference type="OMA" id="MDLMTFL"/>
    <dbReference type="OrthoDB" id="138195at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1111"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1224"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1247"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1339"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1366"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="338"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="748"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="1114"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1051"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="993"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="780"/>
            <end position="787"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD16099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1456" mass="158604" checksum="7B036D32A3C33F8C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ2</accession>
    <name>F9WFZ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002205">
        <property type="protein sequence ID" value="CCD16222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="12881" checksum="2D9809821A240A34" modified="2011-10-19" version="1">MKSACNKWAALARSHRTHAWPSLLSSLPHYTTGGSICCRGVQPKSAGITHPSLLPTLHMPFSAASSIQMLTGISHGAVTRPAVQHSNKLHPEYLRCDGHSSQSHSTAHLQALMQSHFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG46</accession>
    <name>F9WG46_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002229">
        <property type="protein sequence ID" value="CCD16279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01400"/>
    <dbReference type="OrthoDB" id="1667112at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="388" mass="42702" checksum="6CED0A9C96A61DE6" modified="2011-10-19" version="1">MVRECTVDGYISWENITSYLDKLKRFDTLRSNYRRQRKCLCCSRYNCSSYVARRLRKIVKCAYCGMEMEWMHVGVHEKQECEERRRRELCCARDVMLLGDTLCGRTKSCRGHLFLCVICKAAFPSAMQYSKHVCRDPSVPSIMASTVEASIHYDDDFPADEHVPVESAPADGNAVSPPIVPPLKLPCFEQGKSREPPLLNRQHKNRLPKSHGSSYAPCWNRDGSKPVVDAVVKEPPGTLSGAGLDGEKRDDCNNKEGAREGVRKPSRGGPPRSKDGNPLDPGAKDAVAVGKTDHETPPCSAESSWSSATIHIVNRDYLTPERRSLLVEGSPASATPGVKTGSVQQGAREAKRLFPHLQEPCGGAPAQLKVPLRAGKRGLKSSRSSSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG53</accession>
    <name>F9WG53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002232">
        <property type="protein sequence ID" value="CCD16287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00010"/>
    <dbReference type="OMA" id="WHPRRIS"/>
    <dbReference type="OrthoDB" id="544226at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1239" mass="136715" checksum="7B30B81950B114AB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG70</accession>
    <name>F9WG70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 471</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002238">
        <property type="protein sequence ID" value="CCD16304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12440"/>
    <dbReference type="OrthoDB" id="1734885at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395013" evidence="1">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17468" checksum="AB295C477055A9E1" modified="2011-10-19" version="1">MRMYVVVVILLLMKYKIKLRILTEMREHEDLGPCAPRLNGAALILTWSRWWTRRPGAQTSTDLPGTPPTGSLKIIFPGEEMKIGNEKKRFLIFFKEKEKRGKDIYHLCTCVRVSVVMSFLPLLRLWCRWCLFVAQRCGAMPYVCASGMWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE2</accession>
    <name>F9WGE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01520"/>
    <dbReference type="OrthoDB" id="1711446at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="18449" checksum="1BFFEE1F91C4EEFD" modified="2011-10-19" version="1">MSPDRINLYWFLRPMCPVVHEWYARCTLCNFVRNPRHCIPEANVCDVLWQYLPYLLWKFRLCSTPFVRHFGPTETWERWQWDSWKIYINMDDTPLEAIDEEIWHRCHRQPPSPYLPYNRVLFVETTPSFIEIPLPTVGYLVQIPVTPRPWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGG8</accession>
    <name>F9WGG8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_13280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002269">
        <property type="protein sequence ID" value="CCD16404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13280"/>
    <dbReference type="OrthoDB" id="1669636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="36"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="407" mass="44206" checksum="215080E7E2D0AE3A" modified="2011-10-19" version="1">MHKVTNKVEQRLTVMVMELRINWWWLVASSVFMAWSSAFGEGNAPKAIPTKAGAAICTLSKTLKEVTPWATQQVEEGSAKVTNLEMKLLEWQTKWVQSKAQGKGSEACKMTGLLFRQVRKEIDKVREEVERLEKEASKAAAFAANSAGRLDEFITVFANAKGESNGFCLGDTNAAKPEDLRDCFSKTDFSEESLVDIGERASAQEPNLFSKIEGIKYSFLSSHFTAGSGGGCNLIKGDTGGILKSTSLEKSLWWGGGVLTIGKGFDGVLNGSNLGPGEIANDTKEGKNALWTADPATQIVHLKNASDAFKAFKAVQETIQEKVKSIEDKMEGCLTGQEPGENNTEQNATTEQTPNTLTCFDNVARIAADLKEKGALLARYQKVKGWIPPSSASHPTTQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGI3</accession>
    <name>F9WGI3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 504</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002275">
        <property type="protein sequence ID" value="CCD16419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13400"/>
    <dbReference type="OMA" id="NMSICVY"/>
    <dbReference type="OrthoDB" id="818652at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="PTHR37845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="312" mass="34562" checksum="1C7448635FCAC1FA" modified="2011-10-19" version="1">MSDKRDVVEEKSVLHPHCVRRFTAGIVISDIATAAAVGFTAAIPISIVDYSIMARVAGVTNSSKRVLLEGIRTLFMRPHRFFLPCKDNKCAPVFGACFVVYSLTFSASNTTKSYCESKGYSAERSNLFTGVAGGICNTAMTMWKDSLILRILPPVGGTPCSSGRPKPVPWLTRGLFITRDVFTCLAAFTFTPLVATWLTNYCCNVKENARLSQPLPTEGKISLPLSTADTAQLITPTALQTVTTLMHIYAIRYRQTYPNFTFKDYTTSLRETYCSSLLLRVMRILPSFGIGGIFNRELRSNLQDRVEGPSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGQ1</accession>
    <name>F9WGQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002301">
        <property type="protein sequence ID" value="CCD16488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14070"/>
    <dbReference type="OrthoDB" id="1654867at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="807" mass="91774" checksum="0DE75B88C220AFAB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGV1</accession>
    <name>F9WGV1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative histone H3</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein TCIL3000_1_1300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_14530</name>
        <name evidence="4" type="ORF">TCIL3000_1_1300</name>
        <name evidence="5" type="ORF">TCIL3000_1_1310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575314">
        <property type="protein sequence ID" value="CCC89362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE575314">
        <property type="protein sequence ID" value="CCC89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002331">
        <property type="protein sequence ID" value="CCD16539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_1_1300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_1_1310"/>
    <dbReference type="OMA" id="HIVMART"/>
    <dbReference type="OrthoDB" id="1564596at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="Histone_H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="PTHR11426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone" evidence="3">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC89362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14792" checksum="BAE559AA43843001" modified="2011-10-19" version="1">MSRTKETARTKKTITSKKSKKASKGADSASGVKVAHRRWRPGTVALREIRHFQRSTDLLLQKAPFQRLVREVSGAQKEGLRFQSSAILAAQEATESYIVSLLADTNRACIHSGRVTIQPKDIHLALCLRGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH90</accession>
    <name>F9WH90_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 614</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_15860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002396">
        <property type="protein sequence ID" value="CCD16679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="EHDTTQS"/>
    <dbReference type="OrthoDB" id="1658230at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389134" evidence="3">
        <location>
            <begin position="27"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="64736" checksum="A1D04C5474F906F8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH94</accession>
    <name>F9WH94_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002398">
        <property type="protein sequence ID" value="CCD16683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="170928at199999999"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16073" checksum="F158D5804F7A3937" modified="2011-10-19" version="1">MKDTDCLEQEELKIVQGGAVCKNIRRCAKVLWEFTCDNGETAKYVLELASFTLASGETAVKTFSVEGNDNLIETLVHVEAWEDKCLRSGERKKGCYRHAFKSTLVGHSDSAGSGQQVLDTDKALACYMPSCTVCGVNMRPLTNGTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA9</accession>
    <name>F9WHA9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 624</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002408">
        <property type="protein sequence ID" value="CCD16699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16050"/>
    <dbReference type="OrthoDB" id="1718108at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17067" checksum="AC822E776760BFA1" modified="2011-10-19" version="1" fragment="single">MTSLEPLPYTRAQTPSFMALQATLPECEATYSNKAHTHSRGNKHAFNGNYGSCEKVADQCLAWRLLSHTASRTRAQWAPSHISALKVWLCSNMKSARNKWAALALSHHTHAWPHSSARCHITPLEAEFVAGACSQSQLASRIPPCYQHCTCHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB6</accession>
    <name>F9WHB6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_16140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002410">
        <property type="protein sequence ID" value="CCD16708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16140"/>
    <dbReference type="OMA" id="VYAEKNQ"/>
    <dbReference type="OrthoDB" id="1197480at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="31951" checksum="3B53556E136C9F06" modified="2011-10-19" version="1">MTCSTRWSRAIPVARVAATVLIILVVSVHYRFPSLSMLLRTVMLLNRPKGPQGLRPGKEYRRTVPYRSEVTMLRLANNKAFNSNIRELFKKPIMMNNIKAIPRDLGEIPRNYVLKLLLFHQPIRLVDLWNVCKEHDDVPLDSAKHLRLVLKIAKLQRWVYAEKNQTNNLYYYYIHQSRMREVQEMVRAAEVQKKERESLQHLQAEKERQEERERLAVALDDSIVALQQVLVSNIAQIQEFDPDYVREKPYVTEDGAVNVGWGFGGDMPGDAVETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN4</accession>
    <name>F9WHN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002464">
        <property type="protein sequence ID" value="CCD16828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01870"/>
    <dbReference type="OrthoDB" id="1670580at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390401" evidence="5">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="96"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="41095" checksum="16145E042471C464" modified="2011-10-19" version="1">MMMKIVTVILMEVFMAILIHADEMKMVLNTSDFALLCNVTKATNGLLQAVAEASPESEDIYKKELEISNKINEISFFFGKRSNGRYTGLWPLVTRFAEEKPDRKRVCRSKSGSEGISSAPDSLASVILCLCMGTTGDKRDLCNLKVQNSVSWPTGTSQDIKKVFDEVWGEYSTEGVLKKCGNHGGKRLKTRKAKSCEQHHKTRKNTKRKSITEPPKHSLRREQCVRHSHRRSILAKKNKEIEDIAESILTLIHLEAEKKIQTNRLIPVTAPESTNTPNSDSASLTEPTPLFQTTPTSETISSPVSKDTRKQEAREAPTEKQKSEKVYTEIPKKEEENPDAVLEPNEISSSYITNQMWLFLAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR3</accession>
    <name>F9WHR3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002477">
        <property type="protein sequence ID" value="CCD16857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15473" checksum="B7186BC2A5587C44" modified="2011-10-19" version="1">MSQWPGVAVSSLRSAAAQTNSRVWGAMSGLQHFFRSTIGRLFFKKNLLGHRFNEQNFIGSSLAKEFHSFIVIFAAPRCRHRGLNDRWVGIRTLQWRNSRNAPHAGHLVQAEHMFRVPYEGGIHFHRHIIKTNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR8</accession>
    <name>F9WHR8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002480">
        <property type="protein sequence ID" value="CCD16862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16621" checksum="8FC60B4F5A383734" modified="2011-10-19" version="1">MCGCALMCVLRLFSLKLDRKKKPSKSRGEQIMFFLKKDNPQKKKGEQQQQRGGEERSDMEGKGVERKGGKSEISGCEGCGGVVVVEKRWGSVCVCVCVWGLPSPCVEYTKSGKLIAHTFVFVFVCMHAWRRADRSGLQPNQPPPRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIA5</accession>
    <name>F9WIA5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 75</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002554">
        <property type="protein sequence ID" value="CCD17051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02120"/>
    <dbReference type="OrthoDB" id="1545209at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="25194" checksum="5D66B5669C1A64EB" modified="2011-10-19" version="1">MTLHHPTVLFDLDGTLTDPREGITRSIQYALAKLGIDEPDLTKLEHFIGPPLLQAFMQFYAFDEAKAWEAVNFYRERFKVTGLYENRVFDGVMPLLEELNSQGRQLYIATSKPWEFAREIARHFDFAKHFKVIYGSELDGTRTNKVELIAHLMREERLDPATTLMIGDRKHDLIGARSNGLDSVAVGYGFGSFEELNAEAPTWHFETLDQMHQAFLQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE8</accession>
    <name>F9WIE8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 779</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002580">
        <property type="protein sequence ID" value="CCD17095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VIMRRID"/>
    <dbReference type="OrthoDB" id="1658131at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="555" mass="64160" checksum="D7039B99FAD3A269" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIG6</accession>
    <name>F9WIG6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19650"/>
    <dbReference type="OrthoDB" id="1700664at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="202" mass="23875" checksum="9D5E19901E64A7AA" modified="2011-10-19" version="1">MYFFFHTFPSPILAFSIRIPMSLYTITSPRTIPWSMEKDVVDVLLEGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEVNVCDALWQYLPYLLWKFRQSATPLVKHFGPTQTWTKWHWDSWKIYFDNDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVWVEAAPAFIQVPYSTVGYLLHLPVTTRSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIJ5</accession>
    <name>F9WIJ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 803</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002606">
        <property type="protein sequence ID" value="CCD17143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19900"/>
    <dbReference type="OrthoDB" id="1707089at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20828" checksum="A7C47BAC8B1982A3" modified="2011-10-19" version="1">MKASTPPPSHQLRECRCLLLIRSCYVCVCLEPPFLKYLPPTLSRPNRVPWTTAGPKLIISHTVLPQDEYGCLMYVFLKGCSYRGRQRIRGRAGWKIGRGTCSDGKDRCFLTCLLQPTLTVICGLFLFNLFLEEKKRISEHNFRIILFFCLKKARVYITVPCYGDIMLGMVSCTYCACNGFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIR6</accession>
    <name>F9WIR6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_11_10080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20510</name>
        <name evidence="1" type="ORF">TCIL3000_11_10080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002629">
        <property type="protein sequence ID" value="CCD17214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.10080"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20510"/>
    <dbReference type="OMA" id="TNIKMAN"/>
    <dbReference type="OrthoDB" id="773206at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="PTHR10826"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="SSF54529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC95536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="296" mass="33973" checksum="A8DD28E4D0905DC8" modified="2011-10-19" version="1">MWRRVAAGLCAVQWRRGKMAPRVSHCALSTECVEDEVTRWNRAMEVKYGSGAYKLFRPLYKDLADEMRREAYTKPPPPIEGWSVRHDEEVNLAIFTRHGDVNARTARIVAYAPIAVGNPPKLNDMLYFVDWYPIEVLMERNGAIVHFSVAASEGGMHMRNVRAYSARDGSLAGSGEGRGGSHDSAQREALLSTSDDAVWVRHNLYYDGPCLWHLELDLQNELYDVMQDHGVTLDWVRWAAEWVYYLEHVAYVRWSLGMLYELIPPAQRGPEEDFLTMEEREALAVPVEDWLEAHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ10</accession>
    <name>F9WJ10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_21390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002670">
        <property type="protein sequence ID" value="CCD17311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21390"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389197" evidence="4">
        <location>
            <begin position="35"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="107"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="284" mass="30724" checksum="C59A39AADAA2C64B" modified="2011-10-19" version="1">MLNKLIREVKNRGLFVNVLLATVVICSWCGDAAGQPGAEVKSMDNAEQFALLCRIYNLAKNPPIHHVDLQDHVKIVEEIDTINSSFSESKLLNETEMTVNASLTALKPTTTREAAVAQAILRRISQKAHNILDDIRRLNTTSAIENVKAVFAQVIFGGGGNESDLDKSTLSEVKGRADACGKSGLQSKGQSAGKNLVVDFFCLCAQNSDKNNGIENVCGVKVGSKDDNHSWGANTVLGSPSLWASIKKGCGNLFHRYPNSTKEGHEVLGDFLTHLKSGGVYRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ43</accession>
    <name>F9WJ43_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_21720</name>
        <name evidence="3" type="ORF">TCIL3000_11_5390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002681">
        <property type="protein sequence ID" value="CCD17346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.5390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21720"/>
    <dbReference type="OMA" id="DNSEMND"/>
    <dbReference type="OrthoDB" id="1296938at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833325" evidence="2">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC95125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="249" mass="27791" checksum="37B1D972723D71FE" modified="2011-10-19" version="1">MLGMLSLLLLLLAAKSNRAASNEPIDFSKMRNPLDMDEINEKLRKKVDDDDPVQKSLPDPTDPKFRLPLKCSACGAVIEHVVRLLRPIIEQQSLRAARSGGKVPSDALPKSYEVVDVFENLCGEIARFYGLEVEEEKQKLTLRFSKSFGIKRLQGSWIPSFLTSTCEDLLNSYEEEQLTAMVLGVAKAEADAGRGRVISMNPDQGIVDQVREMVCTNWKESSTGCDHKGLAIDPRTEEDDNSEMNDMDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJC6</accession>
    <name>F9WJC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002710">
        <property type="protein sequence ID" value="CCD17430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22490"/>
    <dbReference type="OrthoDB" id="1655474at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="747" mass="81513" checksum="30B7833C3BFA658C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH4</accession>
    <name>F9WJH4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 912</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002727">
        <property type="protein sequence ID" value="CCD17479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22970"/>
    <dbReference type="OMA" id="SMQGYRM"/>
    <dbReference type="OrthoDB" id="957254at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="265" mass="28901" checksum="4E9D927314345D12" modified="2011-10-19" version="1">MQGWRVSMEDKHVLDVTFRSGANNSEEGLFCVFDGHSGKDCAIRCSELIPKVSRNHLKRHVDGFSEIDFEAVYLEVDALLEGGLSDQSGCTAVSVHVTPTRITCASVGDSRAVLCRNGAAVALSEDHKPERAEERARIEAAGGIVSENRVNGQLAMSRAFGDFSYKAQKTQSPREQLVITVPDVVKVDREIGDTFLVLACDGIFDVLSNEQLINSVLAKKGENKPNRDICEEICRECLAPSAEGGRFAARPQGTDNMTLMIVDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJT2</accession>
    <name>F9WJT2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002766">
        <property type="protein sequence ID" value="CCD17590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00140"/>
    <dbReference type="OrthoDB" id="190523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="27038" checksum="6F5943B8515A1F36" modified="2011-10-19" version="1">MKDMRVYRYLRNEFAKTAAGIPMIQLCAALKCFVRGLVEGGETQSLDEQVQQELEREDMDAFLRFCVENLRGFANGMEVKCVLAATESLYQLGYASPEFHEKVARYLASKCSSASPSANSSESANTVCLALGEDLLDRHPEVHSFLLEVEKCGLKGEATLPPTEWMNKNDPANFITPLTETQQEGWNIINRMVDTRASDTEKLTALANEYVAIVKSTRVDDLKCISLVFSRKRFSNRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJT7</accession>
    <name>F9WJT7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 948</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_24020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002768">
        <property type="protein sequence ID" value="CCD17595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24020"/>
    <dbReference type="OrthoDB" id="699045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="472"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="590" mass="66745" checksum="E2C0AC8333BE98A4" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK45</accession>
    <name>F9WK45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002808">
        <property type="protein sequence ID" value="CCD17706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24920"/>
    <dbReference type="OrthoDB" id="1698220at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="236" mass="26003" checksum="14F0727E9EB53EF9" modified="2011-10-19" version="1">MEGRGAKRTRDETEGEAVAPVVQAPARGEVTTATDAVVRHAAVSHEHAVRPSGRWTLDSPVKEVLLEDCAGLSDMSLHDFLMKHFGETFGSSCVSMRVFMGNPSFFLRDESLLTMVTESEPYREYVERYNREYELYKTMREGVDRLSAIGIISLRQWKSAAAANEVEDVGAYVRGVLNAALAIAMRVGIAPSGLEIDGAYGAVVNARWSYVVMSDEYSGKWLGMGVLDLAPRKQPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK55</accession>
    <name>F9WK55_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002812">
        <property type="protein sequence ID" value="CCD17716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25000"/>
    <dbReference type="OMA" id="WRCLRLE"/>
    <dbReference type="OrthoDB" id="715809at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039215">
        <property type="entry name" value="RMI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14790">
        <property type="entry name" value="PTHR14790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1_N" evidence="2">
        <location>
            <begin position="35"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="435" mass="46375" checksum="B69FF54ABC5521BE" modified="2011-10-19" version="1">MEQPTDEFLCSNLEYLATLEPPCIAPSLPLLPNGCGLLPDDFQLELPNGDTGSVGSTSIILQVNAVEDVSLPLSRRLREIAPPNAGMSATQSGRAEERSLEEMLRSMENDEPSSSHHGRAQRLLQFMLTDGFTRVIAMEDCRKGCDALRGGVAWGAKLRVFAPLRIRHGVLILESDKTVLLGGYVKELQEFWIQYATTKLHQLSGRPGRMALASSAQNDSVVPATTADGSANNAGNPPNAAPLQPPAKVPPPPPSFQSALPQQQQQQQGDPVVGTSLVRGNGIPTRLAPTPPPPPQSPITASLFTVVAVISEVSSPLTIREGSACAPGEMPAFSLQVTLALPSQQSTDASGGSGNGGGSSLLVDLGNTWLTHLIGMDVESFRALSASQDPDDMLQLRDLVLLIGSTLENFGTAEFHLHRRAVDDQLEIVQVRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W370</accession>
    <name>F9W370_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000364">
        <property type="protein sequence ID" value="CCD11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1332773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16519" checksum="F425869D8D49134D" modified="2011-10-19" version="1">MLSAIMNKIEIVTIALGALYIHEKRPRWIMEYVENEMLKDEDIIISVDGSDTIVTERENFDRSVEYFTDVSAATEQDFSSDAVMKGIQISPIIFLADPHCYAPQLDNIIDSMHKEHEARCHWFYKYAYEFADKNSLTSLMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W384</accession>
    <name>F9W384_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000369">
        <property type="protein sequence ID" value="CCD11592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1724643at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384220" evidence="1">
        <location>
            <begin position="16"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="18487" checksum="A2A280F17CAB6BFC" modified="2011-10-19" version="1">MFILVAISTHPLALFHTALNSFAPSSHPPLHVLPVPALCLPLXGCTRGVGLRDTPWPGCFPRIGADQPLAMGHPTATCEWDACLWLAGPPLPAFGCGTHWCSVSHVFLLSTCLHRGHSRTSSHSAACFSHCDSAFRHLKYICLVICFNGGFSXCAFQTVXEFLLPSFAWAX</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D4</accession>
    <name>F9W3D4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1040</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000396">
        <property type="protein sequence ID" value="CCD11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26100"/>
    <dbReference type="OrthoDB" id="1655247at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="780" mass="85765" checksum="FCAACA1743888C2F" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I2</accession>
    <name>F9W3I2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000414">
        <property type="protein sequence ID" value="CCD11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="16535" checksum="0CBCCAE15C06C658" modified="2011-10-19" version="1">MSISILFHKIFPEILVPINHGDIVFESPSYYNFPRWKAILNNGNFDFSALFLSVFPGVLGLHFMFTHALLLHLFSGELFFGFYLSSHCPLIPIPWIFHFVYLPPMLSWLLGTFLTSAHGHSVECLGRKQICLFLYVCKFLFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M3</accession>
    <name>F9W3M3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000437">
        <property type="protein sequence ID" value="CCD11744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02930"/>
    <dbReference type="OrthoDB" id="1694195at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="23581" checksum="4E980B319BAFAFF1" modified="2011-10-19" version="1">MKKCKDATKNWGGHPNRLGNLAETPTTIHNERRQHRADGGCVHILRDTRERGGRSGAVAKNIFAANKYDEAWKRGMIGVQSLWHVPHQLYAEYERAATPRITMTVPQPSPQTSGTHENPGTSLKFQESFPHPPREVLVDEQGHTILLEDNNFPEYSLNSTEAGWEAEEHHTNVRGKTPASDPMSDSDPLFPPEAAEGVIAHFTEAAHEGGAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z3</accession>
    <name>F9W3Z3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28110"/>
    <dbReference type="OrthoDB" id="1661867at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="418" mass="47589" checksum="B95F3F5733E3A149" modified="2011-10-19" version="1">MVSFSLYLSCALSVKGCLVSRKMKDPWTMGMVLVMTVFIRGVRGVWTWNPHYKQGHNFNGEAHDALCKVFQASAELWEASQTPGKKLDNGLETGLLQALNQTLFGSSRVGTEQPLDGMNVTLPKEYHATSHRGDWCGKCNHGNTDLHPGSSIPHDLMCLCTPGYYSMPFYVWQWNFWYVRWDYRETNFTLCGRRRAEMVQDQYQGWYYWYKGTAAIEDAWKTVVWGCLNNRTKTTGTGSPGLEEKIKKLNGTLQNFTKILKHASSHYKLGGLNDTNTASDGRSERRMHVLYDTCDGKRKPWWKILNETLHKNHPHELVLNRTPTTLHAIGASLQDRTKGEEVRAESMEDQERTSAQGGNATWGHALNSTLHQNNTGSHEDDLTPRSLYHWSRRVTSSAPQPQPLTSPLLAFMVVLWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W448</accession>
    <name>F9W448_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28690"/>
    <dbReference type="OMA" id="IMISCAN"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="493" mass="54878" checksum="5C3B63008E0C8609" modified="2011-10-19" version="1">MLGVSPRRSELPLERKLHEDMVLFCLLQETHLASAECAALKIGGYQHVGQARTPHGGEVSILVRDGVGVEVGILEKEVPERATVTLRFSADVSLTIISAYFPRKADVSSEALDTLLGANGEMVIGADVNSHHVLWDPLRPSDDKRECIVDWCVQNDMRIANTGWATRRQPGTAALSSPDITLCRDCEISNWKFALSPDSDHHWIPFDVCVGVSLDVMAPSKPVRALYSWNKARWNDFKKLSDDFIFRGMKRSAKGADALNEAMTRGIRMAAKRTIPKGKGVAPSFWTPELTKLDKMVQECKNERKRDALIRWRRKVLVDTAMGRWKENVLKLSTTDSASWNLVKSIYAPRPLTSPVLVVDGHPSTKRQQAQALANMYMARSTKAPHAPEMRIPSTRRSTFRPITKAELDVALRELSSGTAPGDDEIHCEELKELGRVAKKCVLRLFNCSLRTGQVPAKWKHGIIVPLLKPNKPAGSMASFRPITLTSTLCTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W466</accession>
    <name>F9W466_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1151</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000520">
        <property type="protein sequence ID" value="CCD11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28880"/>
    <dbReference type="OMA" id="WAAGTTF"/>
    <dbReference type="OrthoDB" id="1416139at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20718" checksum="4C7E384A1875F725" modified="2011-10-19" version="1">MSHALSWFTSGKAAGAHCAVVGEKEAGERNELLNVTEDAQLSQGGRIVGEAAFIRSNRRHKVADAVLALVAYTFSGFIYMYGQGTALTTLSMWAAGTTFLLNMQVRKVFELEDEEKRLRVAADAGLQEKNVFQLEMVASWVWLLCSMQQFKIHKRLKYSGYSSWTALGCCSYFTLRHMCQKLLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4F0</accession>
    <name>F9W4F0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1175</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000547">
        <property type="protein sequence ID" value="CCD12041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29610"/>
    <dbReference type="OrthoDB" id="1704426at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="22109" checksum="1FE5EAC05E03D068" modified="2011-10-19" version="1">MPKRLAWSPEGEDQAAWLPERPQPKSGKEEAAPLPEDDEWMVWIRARRQEFRNPSWTMRTTIGEVLMEGMKDPRNLNLFHFLHLYYRDVPENVVRFTVGDFLRDPERCIENGQWRRDIGMNLGRIRGRLSERLLHTSYDLFLCHIKTLEDWVRRGRKETVEAIARSLLDQALEQVQEAHTQEEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G1</accession>
    <name>F9W4G1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000549">
        <property type="protein sequence ID" value="CCD12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29720"/>
    <dbReference type="OrthoDB" id="1679734at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388652" evidence="1">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="35188" checksum="F38BC0055535C005" modified="2011-10-19" version="1" fragment="single">MRALAYVGMVSLMALISGNMTGGDVGACELSDEAARVLCTLADLLRASKHTADNYVQRHLEEPFEEVKLHKIIVDQNSELLEELLAKAVNEGKYTEKDADELESNAEGVQQVNDWDYVRAMEARARAREYQQWVRENTGKAIDKLPAKFRGDRSNDSTDLCTRKGYKQHMGKRTKEILGNSTGIENSRRYCSDMGFALKKYLDKWQAVKENEANENCAFDTETRNYAREVRDHMLRLAINLADVERAKDSSLLYLALVLSLRAGVRQNRSIERIVREANDTVKLGVKLPKWVDGNVSVNGTGDLKGADGARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R3</accession>
    <name>F9W4R3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000593">
        <property type="protein sequence ID" value="CCD12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30710"/>
    <dbReference type="OMA" id="PFHAASE"/>
    <dbReference type="OrthoDB" id="433108at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="22121" checksum="CC7C85BCB785FDA5" modified="2011-10-19" version="1">MELIPNGIYVKVTESNVSEFLRLLADKSAALSGRVRRLESIRRLEVAGVSLQDLSRDKDKFSPTHFSKDIFAPYDARTCFLVDADASEEILPLYLREQEELQRKADTYYLRVIRQGDIKTWRTIFDHVQSDPSALKRYGVTFCVPSALSSRDAEGDRELNVHELITRGSNTPVEESQLWLFTKMVKQLLQPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4X2</accession>
    <name>F9W4X2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_31230</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000626">
        <property type="protein sequence ID" value="CCD12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F9W4X2"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31230"/>
    <dbReference type="OMA" id="KVGICYQ"/>
    <dbReference type="OrthoDB" id="514396at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="451" mass="49787" checksum="68BF6E3EFED70D72" modified="2011-10-19" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGAMPSDKTIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVYHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAAMLDNEAIYDLTRRNLDIERPTYTNLNRLIGQVVSSLTASLRFDGALNVDLTEFQTNLVPYPRIHFVLTSYAPVISAEKAYHEQLSVSEISNAVFEPASMMTKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWSPTGFKCGINYQPPTVVPGGDLAKVQRAVCMIANSTAIAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESADMDGEEDVEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W525</accession>
    <name>F9W525_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1266</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_31720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000647">
        <property type="protein sequence ID" value="CCD12272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31720"/>
    <dbReference type="OMA" id="RGHMQAC"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="7">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="447" mass="48542" checksum="283B54C7E883013F" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVTVSTGKAPEAVDWRKKGAVTPVKDQGQCGSCWAFSAIGNIEGQWKVTGHNLTSLSEQMLVSCDTEDLGCAGGLMDNAFKWIVSSNRHNVFTEESYPYASKGGNVPPCRMSGKVVGAKIRDHVDLPKDENAIAEWLAKNGPVAIAVDSTSFQSYTGGVLTSCISKQLDHGVLLVGYDDTSKPPYWIIKNSWSKGWGEEGYIRIEKGTNQCLVKNYATSAVVHRPVPPPPPPASTFTQEFCEGAECQSGCTKATFPTGKCVQLSGAGSVIASCGSNNLTQIVYPLSSSCSGFSVPLTVPLDKCLPIVIGSVMYECSGKAPTESARLVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W542</accession>
    <name>F9W542_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14763" checksum="93B06E348D8B37C3" modified="2011-10-19" version="1">MLFEIILELTDIAAREADRITDSLERNPRALRCRHHNPQPMRSSQLSASAYRRPFRSQSRMEPAALRQKGNKAAAHRLGHFSHEFHKNTDGKRKERNESVEGKETYSNEATTLTAVLKPTRHTHNVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1283</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">TCIL3000_0_32120</name>
    </gene>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000667">
        <property type="protein sequence ID" value="CCD12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32120"/>
    <dbReference type="OrthoDB" id="1750797at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19216" checksum="FF86DDEC31879D70" modified="2011-10-19" version="1">MGKGRHSPSCIWGTRGRKYNKLKQQKTSRCAEEASRAQWFLERRLMWHALAQRTTARERTGRGEQEGGKLPAGDSGGVDGGTDNRCQMFRLPFFSFSFLFFVRVCGCFPLLTTSVSVLERVPFLLEAWRRIVGGGRRGLWGEAGQKSKKAPRALPFTSFPSPVACLVLLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
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    <name>F9W5D7_TRYCI</name>
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        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1316</fullName>
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    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000703">
        <property type="protein sequence ID" value="CCD12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32710"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="297" mass="32780" checksum="6CFD02E1440A196C" modified="2011-10-19" version="1">MFNSENDLLNHLETRHPDGTMDGPSAVDAAAIADVAQFTAREATAGVDQRVHVVCDLCTSSSKVYNMPSALFSHIRFKHPSEDAAFHVERLLRAQKSAPSFVCKVCQKVFASAAALDGHFSSKHAEKVEVMAGSGPVVANNCWWCHDCEKGFSSAKGLHGHMQNKHGLSSQTHPCPACKRVFADIYSLEEHLTLQHKTIRLSDIGLHTHAECAVCHRFFLSHEELHRHAVKHHKKDPRAPVLPFESPALKTRVADAEQPASHALQTSEPQPITSTQQGPRKVMRRKKRSAENGESSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5F2</accession>
    <name>F9W5F2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1321</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000709">
        <property type="protein sequence ID" value="CCD12404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32840"/>
    <dbReference type="OrthoDB" id="1726051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16581" checksum="95D46AB64BB5EB00" modified="2011-10-19" version="1">MHGTHAHTPGTSSDAGCTHTHGRVQQQDTHCASATQHVMHLPHGEETKAGKPTHMFSFVYFQYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVSRGADTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S1</accession>
    <name>F9W5S1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_33960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000757">
        <property type="protein sequence ID" value="CCD12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33960"/>
    <dbReference type="OrthoDB" id="1676282at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389906" evidence="5">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="35"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="37886" checksum="4624AC3A87B6038A" modified="2011-10-19" version="1">MSMKFWVVFCLCMMGVVRANDHNKEAHRALCDVLKAAANKWESVKDSDSPLKQALGRTIFGNKSGGNLETLGKIIPKDYEKVVNHSVSRALWCGQPYDNPHNQPRWPGHSAPHDLVCLCTTGKNGYPLNEDNSKQLCGKTLSDLGGETSQGWSQQGSGKSQVEATWNSVTSECLSGNVPETSLQNAMDALKQILVRNPNGETQYGNRELLGEGGSGKYPCGGSNQVCVMYYNAAGTVEHKPWWVALEKEINNEEQRQQQKKREEEKHKKEESQNNLKVQNQEQPQNNIALRTAALRYTTPSNEETEQSNPENISSPIATIEDTSGAFIIPPCTWLLNALLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5V6</accession>
    <name>F9W5V6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1385</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34280a</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000779">
        <property type="protein sequence ID" value="CCD12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34280a"/>
    <dbReference type="OrthoDB" id="1865867at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="34" mass="4288" checksum="DE274183B0B28FE9" modified="2011-10-19" version="1" fragment="single">EDCNNWIPLLIASWTKSHQHSEYHYYQKTQEHYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W660</accession>
    <name>F9W660_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000825">
        <property type="protein sequence ID" value="CCD12664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="12908" checksum="387E5A6F885329CD" modified="2011-10-19" version="1">MSVLSPPPLPVCAAVDTLISGRFLLLVVDCIFEELGGCVKCGIVYLVSVKKRDKIYITREGHCGMTTWFFSFFFFFLLILVVFPLHALYLARSANSCSLCFILTNIALYIIFVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W665</accession>
    <name>F9W665_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000827">
        <property type="protein sequence ID" value="CCD12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15576" checksum="B89EE0AFD465CED2" modified="2011-10-19" version="1">MKMHGIARETVLKLTKVGREAFHEYDGDYDVFLPHVAPLPERGCWPFAPAVSRTSPYSSPMYTASKRNGEEEEGGNTDSVKLKRLWCCKRYASYGRLKRHVLAKHTYKRDSQKRTTSLTRPRTLVRMKLTKMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W670</accession>
    <name>F9W670_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000827">
        <property type="protein sequence ID" value="CCD12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16502" checksum="E3CC495E0DCAC3B9" modified="2011-10-19" version="1">MAYCIYDFDFIHCEQQRSSRTGQSPPGNPHKGRCSLMQAEQKKKMKEVTPWVVKHVKFDSSKIKDLESNFLEWQSEYFQSNSGLSEECSIRGNIFREVQSKQKEAHEKPEEAEKGVSKTVSFASNHAGCLDEFITVFASAKGSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W697</accession>
    <name>F9W697_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_35590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000841">
        <property type="protein sequence ID" value="CCD12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35590"/>
    <dbReference type="OMA" id="ANTRAEH"/>
    <dbReference type="OrthoDB" id="1530619at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="303" mass="34181" checksum="A0E5BF021113F390" modified="2011-10-19" version="1">MLTSLDNTTTDAIQNFHDALQRSQEALRQEEARLAQLSQAAQQQHDANSTRREFIRTQQQPRLDALHREIARVRSLLEQQRCEVRQQQSQLEAIRRPRRDGEAKSSELRRKVEGQQWEYSRRATAVQSVLLQWWCPQNSLENLTAAASRRGAEVEALRRSGAALQAKLEELVAANCQHDSTDDNMSNLAGNGETCDGNENDNTTTAEECCNNGASAESLQQQLKDHHEEREAFLRSSAEVISTRRRESQRLKAELQRLCTAVEEADAARQESQQRLRAALNEHGDACVKCCRCGVDVVGSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D9</accession>
    <name>F9W6D9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000852">
        <property type="protein sequence ID" value="CCD12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35980"/>
    <dbReference type="OrthoDB" id="483501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="609" mass="69141" checksum="6A4512E6B893D0BF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6K7</accession>
    <name>F9W6K7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1485</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000890">
        <property type="protein sequence ID" value="CCD12814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36620"/>
    <dbReference type="OMA" id="EYAMLPV"/>
    <dbReference type="OrthoDB" id="557973at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="476" mass="53586" checksum="ED37E2736B917791" modified="2011-10-19" version="1">MFTHTSVFTGPRVQGRVKRLDKAAVGRLFLPSQISQWPPGYVPACGVAHFLSPDGVSLGDVIDCHREMKTEGGSEIQRDFAADYMMWCQATLRDFVRRLDDRGRRRMRRFCSRDRTMHDAEVRELFNLNPYAPPMSSISADRTARVASANDSKVCYQFTPYAVTQEYAMLPVSSSKGPETRVSFTTFPQLRNVLYTEFDSMGPGRAISLLSGDDYFLTAELLQELISYLRRRVGEIMSGEEEFRRFSPSSMGSGTKEGTHHSFSSETPVVSFFGNGRLPWLLNDSGLLPFPVVPVRLPAHAAVQERRQKRLHARDGLVAELFESGVVTDSFSTMFPCECISVQDALLKYRPCLILVEPHVDRDWICDLRGFYTTREVLIIGPVDSPAMCSFGFPFLSFGVTSGPTTYWAYNDMLQRVSAAHRIQMPIDPPYVSQGYSRISVDNISAYLMSPNDCPAIGSQHRCISFLRKVYPTMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W722</accession>
    <name>F9W722_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000965">
        <property type="protein sequence ID" value="CCD12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37990"/>
    <dbReference type="OrthoDB" id="1664156at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="415" mass="46659" checksum="432E4B7238CEC60F" modified="2011-10-19" version="1">MMVCWWFVCDKCYSLFLFCLGMKIKEAWIARKGVLSIVVFMAMVMEDVRVYSYPDGTVFNDREYKALCDVFQASLDLWNASRESAFKLGSGLEGILRQALFGTYGTRNMDSITNALPRDYKNPRLWNRGTRCGGCHKDDKFYYPGSSITHDFMCLCTPGQGAEPFYGFYFLFYKENGFKLCGRGREEMVPDRYHGWYTEARGSKVSKVLERSWESVVWGCFNGWKIKPEQGSLDLKGKVTKLNATMKNFTMILKQVNNLDKLGGFEEHTEADGSDERHIHVRYAHCNSKKRPWWKKLKETLDGKKPEDLLVSRPVNLPAGRPGEAPEDGLGEELSEEMEENEGDVESGGPTSTEATAAQDGNGTHTQGLSSSTNNTIGTLTGTATGNSTHPRFGYLRSGSHIKQPLLFLSAAFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W786</accession>
    <name>F9W786_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1578</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000994">
        <property type="protein sequence ID" value="CCD13051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38670"/>
    <dbReference type="OrthoDB" id="1713668at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18161" checksum="B15F6070F86AFFFB" modified="2011-10-19" version="1">MQRHLCSEALHTVLYTFEPCSLDPCFRRFVSCSSHRLLRTPPSPYPFLFPHFVPRSLNGHCLPCHFHFATGGAISHGAPGENVSSLGIQAELILFLCARRSIFRSFVIIVTTLPRMAPLPSQPPLPFILPHHASGTATPHHPPVVLLPGGVSIAAVLPAFAECALCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B5</accession>
    <name>F9W7B5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_04070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04070"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="384" mass="42342" checksum="3A0CA701C762C8FE" modified="2011-10-19" version="1">MVSRRIGRGILAILVAMVVGIRARDINKKEHAKICEALVQTITLWKMVESKEWIPSMGLASALRVAIFGDERVGLVGDLKETLPEAYVIPGHRGQWCASCNHNEEKHPGKSIPHDIMCLCSTGRCEEPFQYHGWSGCKGYWTEHTLCGKTHEELGHPDGGGWWSKGGPETTQRSTGNLTKYLQISWNQTVWGCMKAAIQNNAPPKENIQMQLAKLNQTLEDFEKLLKGKNQKNTYGGSSDSTSDHASDQYTFYVHYGSCGDASHGGEAKKPWWKRLLEALKRNTNASREEEEAFFNSASTGSTAGYYGGSYQHTQGHPAQDGGPPQAVERSSTTQGNGSHTHGSINNTMGGHEEGNHTGSRFQYLRSSTTITRPLCLLSTSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7D7</accession>
    <name>F9W7D7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001011">
        <property type="protein sequence ID" value="CCD13103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38880"/>
    <dbReference type="OrthoDB" id="331433at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="PTHR10527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="2">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="24976" checksum="34E2983066BA0255" modified="2011-10-19" version="1">MSSPNCGVDMSQEQLQCMLHTILHSADNNERRSIEKTVVRSLGTPATLTMLLSIVQNVQGSSSGVRQLAAVLLRKKVLSLWRAIPQESRGILKGSLLQQLGCEPVKAVRLALAHLVARLARADAQEDEGDGWPELIHAIHAAASDPRMEMREMAMIVACSVAEVTTQPRAQSDLVVEAVLQGMLDMEDSVQRPAVKAAEALLVFLREQKRQWENLVQRLVPQCVALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W808</accession>
    <name>F9W808_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1687</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_40950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001116">
        <property type="protein sequence ID" value="CCD13332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40950"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389930" evidence="4">
        <location>
            <begin position="26"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="50"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="239" mass="25822" checksum="41AC57AB3E57C8CD" modified="2011-10-19" version="1">MDSGMWRRVLLVLVVLGMEGREVKGSNQEVYKKLCDITGILSALLNEEKYSGVTNTLREALYGGNWQDPFVNGHFTGKCGLVYPPSRSTYCSHIGMGGSGATNNHGCFAHSLLGTCLCICVPGNDRKDYCGLGDNVGKGASWISWYDDVNNLFKEVWDKINQNCTARNTTVGASGLLETLENAVEGIKKEAQDRKLNKGYFTLGGTGTSGVCGGTSQGDACVTYAAKNNIPHIPWADKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W811</accession>
    <name>F9W811_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27050</name>
        <name evidence="3" type="ORF">TCIL3000_0_40980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000442">
        <property type="protein sequence ID" value="CCD11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001120">
        <property type="protein sequence ID" value="CCD13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="14833" checksum="75E7809B0394A49C" modified="2011-10-19" version="1">MEGRKTEKWSISRGREKGPHLGSPVVCGLRRGAGTFGGIRSGVSPIEPSVIPSIAAPQSSSAPRYSQDHSVPGQAQCLEAGGPAVVEAADTPEAHSPTDPGRRHLLGLQAALKRPSSTLREASDFGPPQAPAPPIQEDLFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W885</accession>
    <name>F9W885_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1717</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001150">
        <property type="protein sequence ID" value="CCD13415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41650"/>
    <dbReference type="OrthoDB" id="1735981at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20332" checksum="37DBCE71C6D5FC52" modified="2011-10-19" version="1">MSLGSAASVGVMSYDRQLSVMFEAGVSKLYSTTSPPDSAPPRYSVSAHVGYRSSAHTVAQHAGSRIDKSNTVFIFPFYAPFTTHRSLNTKSGSKALPEVARSNETSKLLPFFFLEGSDMLLQPVFFFCTTLQPALLKGVVLCYVGLLLLFFLCMVLYTYIILSFPFGSPSFTPSSFPLIALLLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L3</accession>
    <name>F9W8L3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001181">
        <property type="protein sequence ID" value="CCD13547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13910" checksum="4223BBC77D1619F8" modified="2011-10-19" version="1">MAQRVKDCSATKIEVLVSSTPRAEGFGRTYRDRSWPSCVHEPMRRRSNTSIMRILLRNRWARQRCLFEMRRNAWYNKGPGFNSQLCGASKKQDVEERVRKADNEEPNDATRCGQETGTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8S0</accession>
    <name>F9W8S0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001208">
        <property type="protein sequence ID" value="CCD13606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15435" checksum="C776449B2857EB74" modified="2011-10-19" version="1">MCVWGRSSQHRVRTLMCYARAAERQRAALFSLYLHFVHHFSFLLSLFISIRGEDGCLLDPLHFVHTHLSSTSMFSFLLATVANDNVCDDNMLPRHQSQLAFRWLLSVFLMRLTSHLFPLLYHTFSLSQCVVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Y9</accession>
    <name>F9W8Y9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001243">
        <property type="protein sequence ID" value="CCD13675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04570"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17113" checksum="5F4330C7AEF32C56" modified="2011-10-19" version="1">MVVPCLRPREDVDITPELGQFYDIDEKLVRSEKVSVVAVLSSALGWPNRMHIPQQPLQALPAPQGGSSDYAHLYIRKVMMSVWYIIEEELDHWLKPNDCRMPQYHIAIGTAGIGKTRGMGPFLLYQLLHYSLEGLCALTYFSREEVCILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W916</accession>
    <name>F9W916_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04620"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18044" checksum="A3066213DAA88F53" modified="2011-10-19" version="1">MKNNNYYVDSNAIVHGIPWGDGIFTVQGGDQGDWKQVPSKDVTVLKSAAEDYQVFVSLLKSIHSIYAVIKADWVKNKLVSDNTIRNVLYTIKTTEGQKRRVSEEDDNSPEGPPWFPTWNPSNMRNKLLEDELTLCEEHKRSGTAGVSIPLPLFLCFIVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W972</accession>
    <name>F9W972_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1829</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_44690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001274">
        <property type="protein sequence ID" value="CCD13762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44690"/>
    <dbReference type="OMA" id="CGANDAY"/>
    <dbReference type="OrthoDB" id="1576311at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="SSF47676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="276"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="377" mass="42439" checksum="F87F32265EF8ADA9" modified="2011-10-19" version="1">MTSSLAINTLVWLKQPGYPWWPGFVVDPTTVGMELSEGYDTCVLCLPFDSSSVALASSSNVEEIRRFLPEEDSRLLEDGRVDSVCAAAIDEALDMYEKQLHSAEKKQQQSMRKRHHDDGDGVPEHGDLDALFFDDSERDTDGSSQRERKYSPTRKREKRRKRRNEEDIGHTSKRTKKRDKLKLTRRERREKISGTDSEDTSSTQEGEIESSDSDVGARVGVKQTRGKKASRNGVEFSDENDIGASYMENDIGLFKHELRRNRYDASNAVLSRSHDELLGMHSRFTKVGASSFSLEDEEKILEILTTLAKVNVTLEQLIQTKVGVAVGQFISDDFPPRIAKLSHAILNYWFGQLPKDVRGKLLAKSKTIEPPAISTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9F2</accession>
    <name>F9W9F2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1854</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_45430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001302">
        <property type="protein sequence ID" value="CCD13852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45430"/>
    <dbReference type="OMA" id="EDLMGCC"/>
    <dbReference type="OrthoDB" id="865289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018652743" evidence="2">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36745" checksum="8B26FF38D0E169AC" modified="2011-10-19" version="1">MRAHVILCSVSVVLLAMNTSALVAREAPLLTKEFVDTVNRLSGGMWTAVYDGRMQNTTVSEAKRLNRATRKPVSVLPRVNFTEEELLAPLPETFDAAEKWPNCPTITEISDQSSCGSCWAVAAATSMTDRYCTIHGVRGLRISAADLLACCGDCGYGCLGGDPDMAWAYFSSEGIASGRCQPYPFPRCSHYTNSTTYPQCSALHLWTPTCNPACTDSTISKKKYRGLKSYSLSGEEDFRRELYFRGPFQAVFDVWSDLFAYKHGVYKHVGGAFIGAHAVRIVGWGNQSGVPYWKIANSWNAEWGDRGYFFMLRGDNECGIEDSGSAGVPAIPNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U7</accession>
    <name>F9W9U7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001351">
        <property type="protein sequence ID" value="CCD14002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46850"/>
    <dbReference type="OMA" id="WTMGSEV"/>
    <dbReference type="OrthoDB" id="1656658at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="608" mass="69596" checksum="2F2BB6F8BCCF0FE2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9W3</accession>
    <name>F9W9W3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001358">
        <property type="protein sequence ID" value="CCD14018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46980"/>
    <dbReference type="OMA" id="HPELDDC"/>
    <dbReference type="OrthoDB" id="1256202at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29913" checksum="8BD79186B68008A1" modified="2011-10-19" version="1">MSNSFAFWVTTIALIAFYVADFLLARLLNSLKDDHPELDECSPEETPDLDPLTVINSLQKTAEEMVDYQRRRFRTGEAGGFAADSTATVDVGDIPPMSAPSSHRKSNVMHTIVVLCGIAGPFVVVFEALLPSVFGWCRFDFPVFVEYIGAFAGLASATVYAGRVSHCSSYRDVTRSQWLELMWFRLDFMCLTSIAAFLGTGSWFVTVCLLAVGFYLAYRVMRIEKRVRALQLETQLVRGEVDVERVYVPGTAEAAQALGTAGRQGYDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9W4</accession>
    <name>F9W9W4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1906</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001359">
        <property type="protein sequence ID" value="CCD14019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46990"/>
    <dbReference type="OrthoDB" id="678655at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="24570" checksum="15200C2311F82752" modified="2011-10-19" version="1">MDGHNIHDNIDPDIHERLMELEAEEDARLQEMEIEASRKRPCYELSDSTVEAVRFIRDKIKVIRMERAMKNPALRRTRKQSVAIEKFNNRTGSQDTRSATPGYSSEGTTKGTRRGRSLSAAQEAVMRDRSSSSHVSTKATRGISCRSASRERSLSVSRGEGYKDVSEKLRAVKLSKVVARPRNRLAKKGEGDRHIPNLRPKHLFTGKVKSNGGRDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9X4</accession>
    <name>F9W9X4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1909</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001362">
        <property type="protein sequence ID" value="CCD14029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47090"/>
    <dbReference type="OMA" id="CTEISAM"/>
    <dbReference type="OrthoDB" id="460023at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="713" mass="78382" checksum="7007BAD79714F083" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9X6</accession>
    <name>F9W9X6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1909</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001362">
        <property type="protein sequence ID" value="CCD14031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47110"/>
    <dbReference type="OMA" id="HVAHLEM"/>
    <dbReference type="OrthoDB" id="1282549at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="ELMO" evidence="2">
        <location>
            <begin position="166"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="369" mass="41484" checksum="93EEF3946057C15F" modified="2011-10-19" version="1">MSTIVSGITQAFNGKCLGYDCPTVVALLVGTGGALVLFYKLFRNRGGKPSSRVPVLKDANIAVKQPELAVSEAATHIVKGEINTLGELVFFFRGRNERTIRINRELFEYLRKTYPSNLPSKAPVVDAGAWKNGLCCAMMQQLCHCEEQAGQLEKERATAFDDDNPQHTALLKRLWLAAGWPQETFARRGNEWADFGFQGLDPATDLRGGGVLALRQFVHFAEVHGEDLKEMMAFNKKSLAEGKHHWYLLAVVSIQLTAQLLLQRDHKIFVPQLEVLYDTVPHGGSAGQLIGVPRSAARLSRQNAASVAADCHGEPDRWINDVSDFEIGFFTLHHQLLLHFRNNWHRDLPHVMEYNNYMPKVFGSFFRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA73</accession>
    <name>F9WA73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1945</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001403">
        <property type="protein sequence ID" value="CCD14129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47890"/>
    <dbReference type="OrthoDB" id="1656887at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="655" mass="72256" checksum="CDCE8D74D1522104" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA94</accession>
    <name>F9WA94_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16983" checksum="4D81B675C0A7AAB8" modified="2011-10-19" version="1">MKTRTAHINLLRLVPLPVVGCRFGILNLEDVKLHSFHFCSSRAFNKCIGTDSGVLRLSLNRSRCSKTTSRHLFALPLLPYDFNSNPNQHYHFKKLTPTRRLIKIYFLWSVWQVTSSCCFALSQKRQAPHGKPLYKLEETQAAAPRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI2</accession>
    <name>F9WAI2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_48900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001438">
        <property type="protein sequence ID" value="CCD14245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48900"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394638" evidence="6">
        <location>
            <begin position="26"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="48"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="38682" checksum="39413D8E01373DA4" modified="2011-10-19" version="1">MEWEIWGRALLFLFVWGMGGRHVEGSNEGVFQKLCEITGNVRVLMGKNGEAEKALREALYGGSGKGHFDEDGTFTHGCGLWVHSRSQYCSHLTGSGSEKHGCFGDSLVGTILCTCVPGQREPKDFCGLGDDVKKGAIWTSGLESHTQDLFRKVLEKINKNCKATTHAADTSGHLEDLKNAVNEIKNEAKKNNFSNGKDGHYLGSGTTTTRFCDGMNASEACVTYPTKVNGKEPNIPWADKIFESIQKLNQTRTQQHSRTSSSGSDTDNGHEDSSEDSAGNDEQEGEEQESEEESAQNHDPQNPSKPSRPRRNRRSTKNQPAEQPAESLKAIIHKDDGTILIQPFWLLSAVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ2</accession>
    <name>F9WAJ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49030"/>
    <dbReference type="OrthoDB" id="1549933at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysR_substrate" evidence="1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="22597" checksum="E59BA78D3A341BBA" modified="2011-10-19" version="1">MKAPSTLTMRWLLARLSRFRALQPGNEVQLTSAWMSIDEVDFNQEPFDCAVLLSNGHFPADWEASYLFAEMLIPVGAPNLLDDGPWDVTRLATAELLHPTPDRRDWRYWLQRMGLSSHVSLKGGQVFDTLELGMIAAARGYGVSMGDLLMVAEDVAQGRLSLPWPTAVATPDNLITLLSNISYVLLHTLHYLIYIKKWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ8</accession>
    <name>F9WAJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49100"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394813" evidence="5">
        <location>
            <begin position="20"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="65"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="47700" checksum="AECC625B07467F3C" modified="2011-10-19" version="1">MMIRKFLLVALLFCVGALSQSPSSGEFNLFCKFLGEANYMTHGPGYVYDEDKDKEVLKEMQALHNATTENMNEFRKRLWVTKDFFQEHPPPTRPENWEKTHNEIGQLIKEGEKEIDKNRNLAKQVNEKIEAAKLLLAQGIYGDHVMELPKNDGNYTKVLENTNSIFNDENSASKSCGNTQEKAGKTLINDLFCVCVGDADDAQGPCHQKIWPPKSWGYTGSTGNWTQIKYGPGYPTLIPSFSESFHIIEQVCWENMTENDFKSENITALLEQYVSLIGKGNDGVKQNKNIFGHSTRSKNRGQVKECDGKQGNWHHNGPEKKNDKICVDYTRNLQGKKYDIPWHNRFKEAAEKMQEAKKIEDRILENSAALLLLKTKAWAAYSREKEDENSNLDDMNISNVLDVAQIPSSLPLSYLSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ4</accession>
    <name>F9WAZ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2039</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001507">
        <property type="protein sequence ID" value="CCD14420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50360"/>
    <dbReference type="OrthoDB" id="582649at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="1">
        <location>
            <begin position="78"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="23362" checksum="8351CD1AD8C0BB2F" modified="2011-10-19" version="1" fragment="single">MACSSTEEDCFTRIPPVAIVFGDDVDASGTPPTVEHNRLVADMVRHYACTPFTRREGSDDATGLAGDVFEWVDSSLPVVTLDDMAAYHDESYVKYLSVRETLSDVDVSVATAGRSTLKDIGDKSLGSYGSPSRPMSVLLPLNEDKKYNLVGESAPFAGLWKSTCAAVSGSLAAARLLAQPGRFAAIHFFGGKRHAKYASAAGFCYINDVVIAALELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB20</accession>
    <name>F9WB20_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001519">
        <property type="protein sequence ID" value="CCD14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50620"/>
    <dbReference type="OMA" id="NGTWEPL"/>
    <dbReference type="OrthoDB" id="493676at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1269" mass="137324" checksum="C4F1885D1C6A423C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH3</accession>
    <name>F9WBH3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52100"/>
    <dbReference type="OrthoDB" id="1719822at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18401" checksum="D9D5DDFCB3EC5BD8" modified="2011-10-19" version="1">MWDAHCQLCCIPSYLIVALPLYISVGGLKRCSRPWDPISHRGPTSQFFPLHVPFHVCGGRSDVRIEVRVAMIATLGNGSERCNGKGLQHSCRILRVAEWESRGESPMSSARARRLFANWKACLRAAGGGEAGRHGEGSRGFRDQTGDTHNRARECQACHGKGGNLCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBL9</accession>
    <name>F9WBL9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001597">
        <property type="protein sequence ID" value="CCD14652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52510"/>
    <dbReference type="OrthoDB" id="1732804at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394654" evidence="1">
        <location>
            <begin position="26"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17032" checksum="417009C64A9F9B25" modified="2011-10-19" version="1">MWKEFTDAYEILLHLFFFFVHDVTTYFPPEEAQFDNFGLMPLPLHCKIRLSALAPHFCRCCSLLGGFFFLFPTSDPRVVLELNRVREGNGVPTRSPTDTQPPLPPSTTIFCSAMCVLSCRDFCCCCSSPECAVIVADGVLFAVPVNVSFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBR5</accession>
    <name>F9WBR5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_52930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001617">
        <property type="protein sequence ID" value="CCD14699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52930"/>
    <dbReference type="OMA" id="LREMERC"/>
    <dbReference type="OrthoDB" id="131230at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="PTHR11932"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="SSF75632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULLIN_2" evidence="3">
        <location>
            <begin position="542"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="947" mass="106841" checksum="7B2934AD29E28E67" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC55</accession>
    <name>F9WC55_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001671">
        <property type="protein sequence ID" value="CCD14847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54240"/>
    <dbReference type="OrthoDB" id="1661220at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="453" mass="51597" checksum="933985BF009494CB" modified="2011-10-19" version="1">MSFLVFHHPARCKTVFATIISCYSVSFLVFRHPARCKTVFATIISCYFVSFLVFRHLARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCYSVSFLVFRHPARCKTVFATIISCYSVSFLVFHHLARCKTVFATIISCYSVSFLVFHRLARCKTVLATIISCYSVSFLVFHHLARCKTVLATIISCFSVSFLVFRHPARFKTVLATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCC0</accession>
    <name>F9WCC0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001699">
        <property type="protein sequence ID" value="CCD14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54820"/>
    <dbReference type="OMA" id="GCNRENS"/>
    <dbReference type="OrthoDB" id="1398309at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="PTHR12857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="DUF866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17586" checksum="CFB35738B6B12080" modified="2011-10-19" version="1">MPQYSLLASAETEGVERIQPMRPRDWGMKVECDSCREVSPNYIYVDETEERENAGGGTRNAVFKCSFCKTVITVDVDPSSYGAYYPESEDDTPLVVMEVRGATPVELDVGSNWVVVSEGATFEGADLSTDWMEYDEKSGTAVSVSQFEVSFHRLKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD5</accession>
    <name>F9WCD5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001702">
        <property type="protein sequence ID" value="CCD14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54970"/>
    <dbReference type="OrthoDB" id="551907at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="PTHR12048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="26535" checksum="79CAE8CC30AE1850" modified="2011-10-19" version="1">MSVNGGILDLNRRWFERSLPLRVCSLKEVASDTTTKEEINAMYNEAQEILNEATKEGNTEKGRWYNAQFLSRGTTADKIASAAVKLSDTDFMFFLEGFNLLFDTARTDTHHYEAALKALSVIWTKLMPRRPLKRFVSQFFATLPTDTTARKIVLVHWYIEDYLKRTYAQFLSLAEAMLRDRLQKRRKAWLGLVGKLHLASSQKPQPVANGTDGLISWATRALLWHTTPTTTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ1</accession>
    <name>F9WCJ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001729">
        <property type="protein sequence ID" value="CCD14985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667561at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15508" checksum="9EDD3A855BDDC80F" modified="2011-10-19" version="1">MERSKFKHGEIANASKESDSDTKAFWTEKPSEKIPHLQKTLAAFQAFKDAATRISKKFVEIDNIEKQIQLCLSNETMEERPTQSCFKNAVKLNAELQAANALLSRYHKEKGPLPSGSALILHSRCVFTFCYLIAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCN8</accession>
    <name>F9WCN8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001745">
        <property type="protein sequence ID" value="CCD15033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55990"/>
    <dbReference type="OMA" id="LKASPCE"/>
    <dbReference type="OrthoDB" id="812748at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="603" mass="66379" checksum="83B398EF24918DF6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP4</accession>
    <name>F9WCP4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable eukaryotic initiation factor 4A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP-dependent RNA helicase eIF4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">TCIL3000_0_56050</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">IL3000</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001748">
        <property type="protein sequence ID" value="CCD15039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56050"/>
    <dbReference type="OMA" id="ENYASIP"/>
    <dbReference type="OrthoDB" id="595675at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="16">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="388"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="579"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="746"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="769"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="788"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CCD15039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="803" mass="92271" checksum="65BF1BCA0A90018A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ7</accession>
    <name>F9WCQ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_56180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56180"/>
    <dbReference type="OrthoDB" id="1676288at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394679" evidence="3">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="39888" checksum="54AEC432D77735B6" modified="2011-10-19" version="1">MNMIIRCVKVILLEVLTVIGIEANTFEDMVLDEGDFGLLCNTSKVMTGLLQTVSDASLEINEISEKEHELSVKIDETFFGVERTGGYGGYSVLPEQLRNANPSRNEVCVSQKKSHGMPSASDSLASAIFCLCMRTVQSGEDLCNIPSQNKISWPDTSQTRVAQNEFETAWDIVVMKQCIGHESANLENQKQNLADNLTKLKEKLEKKIPVKKENSCNESNTCAKVTKNPSWLNSLREIGNITNGTLTLLEEHKKKLKSVLQKTEAPVPSNSVSGVTSETKTAPSTVQAKTQVSGGRHKDDQRKVTEVKPKTERKGEQEPEKKSIGMPKKEEKPIPIPDLNETSENLINTPKLCLWTALIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCW1</accession>
    <name>F9WCW1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001779">
        <property type="protein sequence ID" value="CCD15109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56690"/>
    <dbReference type="OMA" id="EITWAVE"/>
    <dbReference type="OrthoDB" id="101637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="749" mass="81533" checksum="6A72B2879A02D047" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD02</accession>
    <name>F9WD02_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_57100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001798">
        <property type="protein sequence ID" value="CCD15150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57100"/>
    <dbReference type="OrthoDB" id="1713126at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25074" checksum="158C9406F8F2D0D4" modified="2011-10-19" version="1">MTISAVHILLIVLLFLNLSSLVLLVFALVRYVMARLHRNDEQENTREADTAVSRQHSVGNIAEHAGYYGEAAYSTRSAAEWPFDYAANVPQWVMQEMPPARLAALERGGMPHRDVRYCVPLPALLQGDGAAGRLNNANAYRSDINAVHTDVFYAAGPHRARPRYASCLGAMVGEATDISSSDGSSCDDDSVATQPARCYIAAVALRTPPTPLSDAASFPSSPDSDVLLSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEC2</accession>
    <name>F9WEC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 2457</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_61120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001972">
        <property type="protein sequence ID" value="CCD15629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61120"/>
    <dbReference type="OMA" id="QHPRCLP"/>
    <dbReference type="OrthoDB" id="1269091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="221" mass="24965" checksum="7310A8BB6CB1E444" modified="2011-10-19" version="1">MCIHLLRYNQVMLCPLFRNVRIIGATPKFASSVMGLTEAVLLMERAPAAVGLNIHFVSPHRMHQLNLEHRGVDQPTDVLTFPGSGSGTPGSKFLSEIILSEHDDCCASSNVDPSALARRRIVLQELGDIYFSVGYIWARCVRRPNRCLPFRDYLEAALSHALLHALGYDHDTPEKLTKMARREKFIKQRLSAWQRRCPTCLRELDGVEMLTSRKTTNESSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI9</accession>
    <name>F9WEI9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002019">
        <property type="protein sequence ID" value="CCD15699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07120"/>
    <dbReference type="OrthoDB" id="769572at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="328" mass="35175" checksum="AF22FAE51629BDE3" modified="2011-10-19" version="1" fragment="single">MLHGLATCIRIICEECSTELRELMQTDDPVSIFLKELLQQMLQSATVICRGGATGSKCVTAVLLTMKSCFSEGVFTLDDESDALEEEEEESAWSEGPSVSTAACNIRHHARQLHEETCGIVRHMCSCGVSPERDVLLAAVEYLNTTLETNMVDSVSTHSAVSALLPHVLHCVHSQEEESTAVICLDFISNLAVGSAETLKGVAREAADALFCCAALSSSVLSNVSAEKAERFPSNESSVRPVAPKHKQFIDTTEYSDGDEITREHGGSGFCEANISDDESSESSTALRAALSRVLDTMSSTCPDELIVHLIPLITSALTRAASSAESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM9</accession>
    <name>F9WEM9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002037">
        <property type="protein sequence ID" value="CCD15740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07520"/>
    <dbReference type="OMA" id="AVCYALP"/>
    <dbReference type="OrthoDB" id="1560716at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16548" checksum="D8F10D4A76A59FFD" modified="2011-10-19" version="1">MPPRKRSLTKKKKPQAPPPSVLHVTTLEEFNEKVLQHQGCALVAVVAAFCNICMATVLPYLENLNASRPPALAALNIVVITVSRKTEELCASLEFGAIPTFLSYSYGVRLHSFCGNNMEKALLIAKHAAQQAELDTASAKEKENAGAEATTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER8</accession>
    <name>F9WER8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 308</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002057">
        <property type="protein sequence ID" value="CCD15784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07950"/>
    <dbReference type="OrthoDB" id="1743148at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20478" checksum="E9D1A2720F142B3F" modified="2011-10-19" version="1">MEAVNRQLKILILGAGGSVDVSCARLAGAVARDVLSCSAALRSGNGDYFRYSPDLEVCRGVSVPEDCKYFSRYGLSFLMHGLPPAVVEKVKILPHDSPLFARMQRVAARVMQNASMETDSDGEVIEDKSGSDDSSEDADTEDEGDEEEESEEDDETDESDEAYEEEEEEDEVDEDEDKSDKWLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF52</accession>
    <name>F9WF52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 350</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_09120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002104">
        <property type="protein sequence ID" value="CCD15920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09120"/>
    <dbReference type="OMA" id="LASFMYH"/>
    <dbReference type="OrthoDB" id="1096393at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="25193" checksum="9F786E53AA994F15" modified="2011-10-19" version="1">MAGHNKADDTRMYTSWIICIISVLSHTTFLPTIHSFFRRRYAFESAMALFGFAASLLYHICQDLNIEIFMDEGAWHRMDNIFVLSFVGAWSVYMCTFRDPFVERITKYSLLMVCMIFQARGPWQPINTIAPVILSLSLPICVYAYRWQVPAFFGKRLAAFAVTMVIAVWFFIKGLDDKRDPFKIYHSMWHFLCGIASYMMWTMVRVPGATGLLGKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF75</accession>
    <name>F9WF75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002111">
        <property type="protein sequence ID" value="CCD15943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1667067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15109" checksum="E300A99473D530FC" modified="2011-10-19" version="1" fragment="single">MPQGRGKRKATGEANHSRKRQRGPSPTLLDPSVEDTRPPRRILRLVEDSPSSLLEPAVVASPHGNTEHVVEDSPASSLDTEVVVMSPPRPPTPPTPPFSIPRKSFLLWTMQSDLGVVLMELSGDPRRLNLYDFSSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF92</accession>
    <name>F9WF92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002117">
        <property type="protein sequence ID" value="CCD15960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="13943" checksum="CAF6F207E6C42B0E" modified="2011-10-19" version="1">MLGATKGGLWPWGQLRGNEMAHLNHVAFLFCWIVGGCLSFNTHAIYGGQGVRAGGGGVWRCCVSGRGLTSAVVVMVIYPNCLTVRMTRWRDVKALLTCTECDGGSWPGRANGISLTAGVLLRVAGYWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA3</accession>
    <name>F9WFA3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01140"/>
    <dbReference type="OMA" id="NISRSYW"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390280" evidence="1">
        <location>
            <begin position="25"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="734" mass="79751" checksum="CC541C4975895A93" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK5</accession>
    <name>F9WFK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_10440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10440"/>
    <dbReference type="OMA" id="RIYYYIG"/>
    <dbReference type="OrthoDB" id="1259147at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="370" mass="40081" checksum="9DAF5C4B941CCF94" modified="2011-10-19" version="1">MFSLNVSPALSWRTTLCTPICAVLLFIPLLITADSGEKIDIFHSGDVTEDDSGLEVGYETVDYQWSVILSLVVIFGPQIGYIFQLYEIKSRGVATGYSPLVSVILLLSNALRILYFVGHSYAVALLFQSIISLPVHMVLVLSVLRYSASSGENSGGSRADDVQVSGGDAHDFSHRVTDAKPSFVTRILQGFDNFVSGMEESVSSSSTSDFTQYSFLYGLVITVSILLYYAAVLPFWRDAPQLVGYTALVLEATLLIPQIMRNYRRGSTKGLSLVLFATWVIGDIAKLVYFIVFKQPVPFLVCSGIQLALDVIVGVQVVVYRCCSRRSGPSLHEVNGPVAPGGDVVITAAAEPPAKDSWEGVVVNGKNTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK9</accession>
    <name>F9WFK9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10480"/>
    <dbReference type="OMA" id="SWWEDAT"/>
    <dbReference type="OrthoDB" id="1156073at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="41220" checksum="DB1D7CEF3E1302BB" modified="2011-10-19" version="1">MWCFLRHDRYRSTDNRFFVGCAISAVAVSSVAIRYFLYGSDAFQCCHCERYPQFGGFFLLRCVNNLLARLFPWKFNKDAAAVGNVYESEAVVRQYMEFHFTPSSKSFEPALRSITEAFDFPLRVARKFHEFKPLTSSKEKRALEIGCATGASSFEMSKYFDSVVGVDYSSAFIKMARKIAKSSCDPNAPPIKYKAPVQGDITIERTLALPSGVFPERCRFFRGDAMDLLHVEGKNAPAANEDSASNDDCSGELYRVSAGEQFDAVLVVNLLCRVPNPKKLVDILPQLLLPGGVLVISSPYSWEGPPEARDTWIGGKSAGAMSEDLVKEMLSIHFELLDESNEAFLIRDHVRRYQLGVSHCTVWRCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFR7</accession>
    <name>F9WFR7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_10960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002181">
        <property type="protein sequence ID" value="CCD16145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10960"/>
    <dbReference type="OMA" id="INSHKRR"/>
    <dbReference type="OrthoDB" id="1285017at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="SSF159042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="3">
        <location>
            <begin position="103"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="291"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="416" mass="45912" checksum="ED160A9CDB1DAE6C" modified="2011-10-19" version="1">MPTNYGLAAQCQLRREDFSELFALVAGAEADCAVPDELSDSNCSSAVSQSIPLRLWRTLLTGAHIRSLMLHTLVRVSIPKSKQALLVHGNRHMNSSARPGDSSSSGKQQHYRVGCVVAVVPRPQSSESRQATAAAANSEDTAALLSSWLLQINFGEAAELLAAKYVSNEPFTKEEHLVYVRSCVSKCANAPVALSSTGETDVVARNVQDIHRFVEAVRSQRNEPSYSSSQQKTANSGDGNTCHAKKRFRAEPGAVGDGIDDSDDDDNNENGHGVVRGVCTAVKCKQQARLVEDQERRLVALRQHLNNKNDELRQILQEQKQAARDHAAQQEQWNAKAEAQGLAMHRVEKELAEERAAKQLLQEKTDQLVTKMKCLAEQTRKYKSVSDTVAEWLCVTSRKPEDVLERVQEKMAETKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT8</accession>
    <name>F9WFT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_11180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11180"/>
    <dbReference type="OMA" id="FWIIANS"/>
    <dbReference type="OrthoDB" id="865289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018641718" evidence="2">
        <location>
            <begin position="22"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37205" checksum="3D8DF96539C861F3" modified="2011-10-19" version="1">MRVYVALGLLSTALVALGASALRAKDAPVLTKTFVDRINQLNGGMWKAVYNGKMQNITFSEAKRLTGAWIQKNSSLPPVRFTEEQLRTELPESFDSAEKWPNCPTIREIADQSACRASWAVSTASAISDRYCTVGGGKQLRISAAHLLSCCKQCGGGCKGGFPGFAWRYYVEYGIASSYCQPYPFPQCEHQGAQGNKTPCSNYKFVTPQCNTTCTDKTIPLIKYRGKDAYMLLPGEEEFKRELYFNGPFVAILFVYTDLFAYKSGVYRNVDGSYMGVTAVKVVGWGKLNGTPYWKVANTWDTDWGMDGYLLILRGNNECNIEHLGFAGTPDTSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG29</accession>
    <name>F9WG29_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_8_6920</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12070</name>
        <name evidence="1" type="ORF">TCIL3000_8_6920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002224">
        <property type="protein sequence ID" value="CCD16259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12070"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_6920"/>
    <dbReference type="OrthoDB" id="826593at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC92465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43097" checksum="C83F9296AEA003AA" modified="2011-10-19" version="1">MYAVKPWGKVILVGSGVEMYALGIGMRWRESNVLLVEKQADPSYELTNRRRCVLTSQTVKILKDLGCTTAKVEGILQRPRGWRFVSPNLEIMREGSTFPGCADGEATYQCTEGVLLRTLRTEFLRFGGDISWGTKAFDAFESGDGSGTWSLRKMYGLETEAEAIITTANETSFTPLLIADDPDRLAVLFDEETGVLPGEGKLAEKIFGTSDVVIVIGSKIVVHMWYIDGVITWRAIRRAQKDVQGIDTADFHPLLREVFQGSTNRLSRVRIIPATTPAIKDSAAHAKVSVLGDGLLPIDPFEWRGDRARCGIEEASVLCRAFYGKKYHRGNVPRLLREVEQDALARRAAALARDLRDAEHFLSPQPVIDAMHHEYVQQNETLSLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT9</accession>
    <name>F9WGT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002324">
        <property type="protein sequence ID" value="CCD16527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14430"/>
    <dbReference type="OMA" id="HTDRTEK"/>
    <dbReference type="OrthoDB" id="572995at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="846"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1253"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1277"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1364"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1397" mass="152205" checksum="43497E33D48A5755" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGZ5</accession>
    <name>F9WGZ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002356">
        <property type="protein sequence ID" value="CCD16584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14940"/>
    <dbReference type="OMA" id="CTAEMEL"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="84"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37185" checksum="5CE8BA27FCD1D907" modified="2011-10-19" version="1">MSTALALALERMHKARSTKAPHAPEMRIPSTRRSTFRPITEAVLDVALRELSSGTAPGDDEIHGEELNERGRVAKKCVLRLFNCSLFTGQVPAKWKHGIIVPLLKPNKPASSRASFRPVTLTSTVCKLMERIVARRVRDCVEDKLQPQQAGFRPVRSTLDTLMQVTSAVRRRKDGGKMAAVFIDYARAFDSVDHNCIVKALMSFGVEKHSVAWIADFLQGRTAQVRVNNTLSEDISLTCGVPQGSVLEPLLFIVTVDSLSKRLNCIPGLQHGNFADDLTIVCTSADLSAIQQTIQQGLDCITNCSEKHYMEVSAERTEYTLLGSHGKNTLKLEVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH53</accession>
    <name>F9WH53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_15500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002377">
        <property type="protein sequence ID" value="CCD16642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15500"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="657"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="684" mass="79702" checksum="D025BDA4936FBBC5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH68</accession>
    <name>F9WH68_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_15650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01002385">
        <property type="protein sequence ID" value="CCD16657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15650"/>
    <dbReference type="OrthoDB" id="24987at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLAc" evidence="4">
        <location>
            <begin position="221"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="525" mass="59246" checksum="C33BDD41578BA907" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH70</accession>
    <name>F9WH70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002388">
        <property type="protein sequence ID" value="CCD16659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15660"/>
    <dbReference type="OrthoDB" id="97957at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1285" mass="140372" checksum="D05831BC236B7BF9" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC9</accession>
    <name>F9WHC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002414">
        <property type="protein sequence ID" value="CCD16721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="14741" checksum="05CEEC82160F72C8" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFVSFLVFRHPARCKTVFATIISCYSCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHE6</accession>
    <name>F9WHE6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_01750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002420">
        <property type="protein sequence ID" value="CCD16739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01750"/>
    <dbReference type="OMA" id="THTIKEK"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389142" evidence="4">
        <location>
            <begin position="22"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="90"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="443" mass="50804" checksum="5048011DE8F64060" modified="2011-10-19" version="1">MITNVIGAFLLYTAVVLHGMAQLQSHNKEEFRVMCKLLSLHEKGIPPPQFENVEKENEIIEEMEFLERATGPDVTNFEGGIWKMKKFLKEHPPPEGEEARKVANEEIRQLLQKAEDVKKRSDQNRKSAIGPWESAQLKVLQAVYGEQANNLTKYLDTHVNFTSNTEKIFESNTTANYSCGGGGDGDGTEPNKGKAVGKTLINDIFCLCVGECNWGNPCHDDIGSPNKATHRKRRQFNCSADTNKGGWTQIKYKAGSKTALSFTESWEAIKKSCDDVLKLEKFDIEINATLTEFDKLLHGDNQSDRNRVILGYKFNHTEISYKCIGNAARLGGWEQSLGYQPPSEHQTCVDYTHTIKEKEDIPWRRKIKEAMNYTTEMEYIVAEEQTYLAELIKLKNSAWVAYNKEKDEEFYEIENYDYNKEEFADFPKTHLLFYTLMYFIFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN5</accession>
    <name>F9WHN5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002464">
        <property type="protein sequence ID" value="CCD16829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01880"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389149" evidence="5">
        <location>
            <begin position="29"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="56"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="39783" checksum="DB95EE421291083D" modified="2011-10-19" version="1">MCKKIKMVYRSFFGLSLVSCIFLEVGSGNGINGEVYDLLCNVTGSASALLKLNEGDGVVQSTLGDAVYGKGSRAQFSPTGTVSLSRRFGVSPTGRGPLCTYYRGTQARVMDGCFTESLFGVLMCVCTPGEGSSGNLCGVEISKYKGGVWSSNFNRALPTDLLNEVWEKVIKNCTGSGAGQDIAQYVEDLKIAVNKVRNSLTSGKISHTDYFYLGEKDNESNCNGVNGKNICAAYQINGKKKENVNIPWADKIDIAVSKIKPKVSRPAVKATLAPAAAEHRVANPAGQAEEHVKPEPQAGPAPNETDEKAENGKLLTETARSPGISNVPTKSKLKRSPKTKPLNEIPHVATNIDEDGFSLTKPLWLSMAALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHP5</accession>
    <name>F9WHP5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 679</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002469">
        <property type="protein sequence ID" value="CCD16839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17290"/>
    <dbReference type="OMA" id="YYSANKR"/>
    <dbReference type="OrthoDB" id="1072587at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013544">
        <property type="entry name" value="DUF1725"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08333">
        <property type="entry name" value="DUF1725"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1725" evidence="1">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="571" mass="67789" checksum="8B804AA60B860596" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHU1</accession>
    <name>F9WHU1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17690"/>
    <dbReference type="OrthoDB" id="894595at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DnaJ_C" evidence="1">
        <location>
            <begin position="4"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="18574" checksum="F8116C26CCB92968" modified="2011-10-19" version="1">MTVYRLRGKGNDGTRGGAAGDLIVTVLVQEHRIFHRDGLDLHMVLPISISTALLGGVVPVPLPHAACSVRVPPCARNGQRIRLAGKGVGLDGSRPAVVGDDGGGTGNSPHGSTRSGCGDLYVHLLVVIPKGEDLTGRQRCVIEKFVECAESNESDTSDEATPASLKERFRHWFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHV4</accession>
    <name>F9WHV4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002488">
        <property type="protein sequence ID" value="CCD16899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17820"/>
    <dbReference type="OrthoDB" id="1751395at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="20451" checksum="AE2709255C9A5538" modified="2011-10-19" version="1">MCGTCSGHFFWFTNTFFTKKFLGTFLKNKNKFKNFRKNLVTGSNSHMSNFFALGAIFPIFQKTKKIAKKRQNVIKKPIKPFFDVRNVFRTLFLVYQHIFHKKIFGHIFEKLCNLFFLFLLCIFLMFLKNFSCGFNLWFVLLCFFYLSFVLCDVIYIFFSCEESNADIHMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHV6</accession>
    <name>F9WHV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002489">
        <property type="protein sequence ID" value="CCD16901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17840"/>
    <dbReference type="OMA" id="CERRECS"/>
    <dbReference type="OrthoDB" id="257128at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="40912" checksum="0C0AEC34ADBBFD81" modified="2011-10-19" version="1">MYVPPRPAIVAVRHSEPQRANRKRAEMLALYKELKHNHINRLDRIITLLYCLLVPSWICHIFSALATDWVLVSRPNSHHSVGLVFSCYLALVGMCIDSGSSLYSRSVHDALTGEVVCEFTDSSARAFISVIWSLGGLELIFITVSLILLLRISRRPTRSGMCVVVLSLLSVDVPCSIANVVLFYLYTRCERRECSALHLSPPECRIEYGWGLNMYLASIFFDLCACITSIYLCSYPGSLRSRAKQLLGQLEKRQQEEWQKAQSRAVWHKSFSISRSERSRERAVPTKNVDVDTTPFLTATELNVVIDGADDWVYDDKSDLFYSFMLDSFWDPTTRCYYNRELQSWLVAPDGQINLREGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI55</accession>
    <name>F9WI55_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TCIL3000_0_18690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01002529">
        <property type="protein sequence ID" value="CCD17000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18690"/>
    <dbReference type="OMA" id="KQVHTDF"/>
    <dbReference type="OrthoDB" id="1139373at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="13">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="77"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="288"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD17000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="633" mass="68934" checksum="CA25A3011B17DDC8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI77</accession>
    <name>F9WI77_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 741</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002538">
        <property type="protein sequence ID" value="CCD17022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18840"/>
    <dbReference type="OrthoDB" id="1201381at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22798" checksum="F7A3416C534A2D79" modified="2011-10-19" version="1">MASVLQGDTPPGSERMKGAEEASLQEGSDSCDYGKAMRALLANRVRQRRVAERERAVRVLAHKGVSLPTPEELRVIAEKRSRYEELLRLRKQIDGVERRAGCWHRYLSYESQESLAPLLPSDTVQSTVAGSFEGSVALVSPLLSLFRMMLHEIRVRKRLELLRTYLSLSKTRVLPTDGSCRVVVEVARLAEEGLTVPPQGRVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII5</accession>
    <name>F9WII5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002602">
        <property type="protein sequence ID" value="CCD17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="687505at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="15"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="26093" checksum="B4BC5947B4C59E74" modified="2011-10-19" version="1" fragment="single">MDNGRIGWILDNRTKFYEVLDVPNDASQKTIRRKYHSLALQLHPDKNPSDSRAREAFCVVMRAYEVLSNEEKRYIYDSCGAEALTALESGDLFSPTKFVVHIGRFLLAKVLILGAYRIHATETLSAMFVWADQFLPRRPEDAFERARMRERXSSRRVAERVFFTSLLLSICVGCMAYSAGPXEXSEXEXEPMSISTVPCLVVADEAMIKERRFVLLWPTRRVRGMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIL8</accession>
    <name>F9WIL8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002617">
        <property type="protein sequence ID" value="CCD17166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20110"/>
    <dbReference type="OrthoDB" id="1786858at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390388" evidence="2">
        <location>
            <begin position="29"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="19047" checksum="6FBD3A23F6009DC0" modified="2011-10-19" version="1">MRVRTSALLVSALSSFSALFPHVPASFAKDAPLLTGGLLQWGPHVACLVVPFLDLPHLTHPTPTAHTLQFPLEHGKPHVPAILSSPPLLSAAVSSAASSAAMHGGSSGSVAPPCFPIRCRSLLAHALSSHLHTRHANSPLAFGPRPLEDRGYPSPPPPPQLTFLSALGVSLATAISTTGTPQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ3</accession>
    <name>F9WIQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 821</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002626">
        <property type="protein sequence ID" value="CCD17201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20380"/>
    <dbReference type="OrthoDB" id="50498at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1764"/>
            <end position="1784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2158" mass="237840" checksum="B0FD957BC70CAC49" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY0</accession>
    <name>F9WIY0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002653">
        <property type="protein sequence ID" value="CCD17279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="15675" checksum="3D7AB0E7D590495E" modified="2011-10-19" version="1">MLQTFHRLPHNVDMENIILGDTKRCMAHDKSAHSEHISTESHLASTTVRYELLLQKRKVMYLVGAYLLQRFEPRHHPLNAVLKQGIRRSLRVFHPLPGCFKSPSHPIALLHSTIRDYRMEKHYQYCYCHYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ06</accession>
    <name>F9WJ06_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 859</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002669">
        <property type="protein sequence ID" value="CCD17307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21350"/>
    <dbReference type="OrthoDB" id="1691680at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395093" evidence="1">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24935" checksum="FDE526E058544E47" modified="2011-10-19" version="1">MGTPQHVSVMAMLPPLWLMCVLWGFATATGEDCKDNVTVHVYNLLYSKKIPPSIYVPLIAGFNASVHAGRKKLPAGVNLNVLHPPSLELGVTPGWLSGNVKRLNERDIPIVVGPVGDLPLLTFLPVLNEHNAVAFSPFTGSSTTRVWNKNLYFITASPTAELLALLRYAVTQLRLERLGFMYLQGISFGDEEYRLTVNALSNIGRELCGLFTVKSSIAGAAPDAELFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ42</accession>
    <name>F9WJ42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_21710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002680">
        <property type="protein sequence ID" value="CCD17345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21710"/>
    <dbReference type="OMA" id="KRCEGAS"/>
    <dbReference type="OrthoDB" id="1673882at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394815" evidence="5">
        <location>
            <begin position="27"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="68"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="373" mass="40301" checksum="245C6F2451090A79" modified="2011-10-19" version="1">MKMIWRGMNVMMMVLGVMGMVMGVYAGGSDVAEGSNKEHFELLCNATKVMLGVLDTVVELGARHAEIQEIGEKESEISNKINEIFFGSKFGGHSDGYVVLPEQFKNANPSRKEVCGSKQASTSTGMPPASESMATVLLCLCTPTSSDVKNLCELEVDGEGSWPPGENQNIREVFEDVWGQWSGKGLMKRCEGASSKTVEEAKQSLNGNLAKLESAINTTGTLGLKQRNCDGTPPCANVTKDPTWLKNLKQFVNVTEEIVTLAKTITTAKKETPRPVSPSESSGQSSLSPQPEATATSAPKPVSSQPQVEPPKLEARETSKEEQIPEPAPKNEEKLSELPQKEEKDTPPHPENNETSGLSLTSPKQLLLAVPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ49</accession>
    <name>F9WJ49_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 872</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_21780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002683">
        <property type="protein sequence ID" value="CCD17352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21780"/>
    <dbReference type="OMA" id="HVEKEPM"/>
    <dbReference type="OrthoDB" id="1338632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394816" evidence="2">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="19093" checksum="51AD865B48A1C43C" modified="2011-10-19" version="1">MARPVVAQLSLSSLRSALAQSTRGGGGKDSHKDKSKRLASSTESEPHVEKEPMQYPVGRSTLQLTGAHFFLSGDTTGSDDEGFLVLLKAHVGGHLDAAPRVFTLAAVPLGGRSIDRSNGGNRATSTFAKLDLRLQMEKISFSLAVLPARRSSGHPSRGKTSTPADCGLRVTVMGVISPLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA2</accession>
    <name>F9WJA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22270"/>
    <dbReference type="OrthoDB" id="1725433at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17137" checksum="7DB2F48AD38EFB50" modified="2011-10-19" version="1">MAPLACGMSGVMAGVSHLVVCPQAVAFFSGGSRALREGTESERHGHTSGIMKALMGLRCLLEAYSLLSLRAAADVTTSLLDLKALFPHVELPCEALRLFCCRATNSDEWRELSPVLVSGVSRVSGHLSVRCVARAARALFGLTNKVLQQQWQDSHGTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP9</accession>
    <name>F9WJP9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 935</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_23700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002752">
        <property type="protein sequence ID" value="CCD17556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23700"/>
    <dbReference type="OMA" id="PRFLWPH"/>
    <dbReference type="OrthoDB" id="782502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="SSF90209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="517" mass="57354" checksum="0AA9BC48403D75FD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK72</accession>
    <name>F9WK72_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002818">
        <property type="protein sequence ID" value="CCD17733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25170"/>
    <dbReference type="OrthoDB" id="1747859at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16728" checksum="942639F25FA6A79E" modified="2011-10-19" version="1">MIRHNFLFPRKLCSPTDVVTQSAGGTAPVVRENGLLVPAAFRRVGGGLAFRAAQLVVMSHGPSGALGHWDLLRSRRTAHCERPRVPTGHPARLCTRSLNDYKKKKKGKSRGVVAAGVAGDLQWGCEFQRQEKERARRNLRQRAPRPKSMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W371</accession>
    <name>F9W371_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1011</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000364">
        <property type="protein sequence ID" value="CCD11579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25500"/>
    <dbReference type="OrthoDB" id="1729858at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="18193" checksum="57F7DE588DC7AE62" modified="2011-10-19" version="1">MSSLDNLTTVISNAKLMSGVYVSALQNILNALRYGYSLEGIIERAKEAGKKGAVIELSSGGTPSGDSAPGTDGGNSSSGGDGAGGTGSSSDGKAETTTLEEDIDLGLEMDDDVMPSSVRISTLGVWLLATLVPFFIILIGVLVFCLVRRRGQGADADGKNSSVTGATMGKGAPGGVRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3C7</accession>
    <name>F9W3C7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_26030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000393">
        <property type="protein sequence ID" value="CCD11637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26030"/>
    <dbReference type="OMA" id="GADVIRM"/>
    <dbReference type="OrthoDB" id="1723543at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389839" evidence="1">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="2">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="26519" checksum="1EA5E06BC29F6AFB" modified="2011-10-19" version="1">MTTTMSRVLHLMTVTLLCARVGMGQASDDGDCGLGGIPQKVEEVQALCDMARQLRALETASQSAVAAVVSSAREASEAKERAEKAVERAKSKKRGVDTATEAAARAAAAAQRAETVVSDARKHAADLTAASKDAIETTDESLRLLATCEKADEPIRTAAKKCTGAAAEVTSKSLESAFDALAELVPDGADVIRMYGAVFVVRLKSLEDDVRTAGEAKSEAEKAEGDANDAADGARAVLTGVCVLLLLAALHFSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3E1</accession>
    <name>F9W3E1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_26170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000398">
        <property type="protein sequence ID" value="CCD11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26170"/>
    <dbReference type="OMA" id="EDHKCMY"/>
    <dbReference type="OrthoDB" id="1352540at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="PTHR22748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="606" mass="67190" checksum="14DF191E9DC0EBB0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3E2</accession>
    <name>F9W3E2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000398">
        <property type="protein sequence ID" value="CCD11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26180"/>
    <dbReference type="OrthoDB" id="1711467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20767" checksum="33A1EFA2ECD4F365" modified="2011-10-19" version="1">MVRPEWQEEVFSARLACYLWRRAPLAADCCKAVALVLARSLNTGKGARDKNLYKRLVATVQHLSSKLCFTRNMFAEVLEPDNQREAIIDAAEYSRLYEVLRTVFVVLSSVPHRAVVTHQPVKKLLISSAKLLMTRCGRYQFLAGRNCQILRGNVMDYKKRERERRLTPKLPVSSSVTSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F1</accession>
    <name>F9W3F1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1046</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000402">
        <property type="protein sequence ID" value="CCD11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26270"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394535" evidence="1">
        <location>
            <begin position="22"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="444" mass="50765" checksum="760E10D06E88E086" modified="2011-10-19" version="1">MVIKKIFPLLALVLCVGLCSSQPSTAEFHLFCRILAEANDMILEQDYVYDENKDRQVLKEIDVLHQATTENMEDFRKMLWETKEFLEKHPPPMQLKNRQEAHREIGMLIADGERKIHESRGLSEKANEEMKKAKLSAVQGLYGDEVKEVPRGEANWTAVRTDTKSIFVDVSSAKKSCGNESNATGKTLINDFFCVCVGEGFDEKVNAPCHDDIMPPKAVKCPNNDCCEKDCCKDGCCTSSCENNCCNCGCWTQMGHKGDERKVLNFSESIKKIEDICKDTLEENLRKNMLSLLVEYQDMIGKGTNDSTTKKIFGHSGRKKKEEVTTCDGTQGSNSDSHKEKYNEKICVNYKNNYNKGNKTYSISWHNKFKNYFMIMKKAKNIKEKILKNRAQLLLLKDKAWTAYTREKDDESANLDDMNMSHIFDGWKLNSVFPFPYLFLILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Q0</accession>
    <name>F9W3Q0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1088</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000450">
        <property type="protein sequence ID" value="CCD11773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27180"/>
    <dbReference type="OMA" id="EHIHEDD"/>
    <dbReference type="OrthoDB" id="1166094at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="PTHR23418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="DUF953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF953" evidence="1">
        <location>
            <begin position="211"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="37483" checksum="54E526BD38A5D2F0" modified="2011-10-19" version="1">MTNSWLLNTQEGDITAPCHCEPDVPVQAVQLEACLVYTRTIDTATLHEQHPTDEESRTYAQRLAWNLGYKALEQVTLTLESKDEIVEHLNVDEQMRIVESGVIFVDVRDGNDQWVRVQGTEGDVIVIPPGIYHRVVPAGTTPVKVLRMLRRSEVFRPIPRDTTGLDEKLVDEAQEAHEEHMFALAHPPVETAMGPANDCDNILVKDPRDFDATLEKVKAGLRPGDILVVLIKGLSNPRTHKSWCPPCVVAEPMVQRAVQAAKQKRHVVYMQCNVERSVYLGNPNYLYRTHPFIKVVGIPHFMVFEQRGSDLTEICRESTPCEAYETWVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U9</accession>
    <name>F9W3U9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000477">
        <property type="protein sequence ID" value="CCD11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27680"/>
    <dbReference type="OrthoDB" id="1676627at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="307" mass="35339" checksum="A06D3E26AB2263DC" modified="2011-10-19" version="1">MEGEREAVPNWTMESAVEQVLIQECKTRGKKSISYFFVEYHGWTEREFRHLTLGEFLKQPERYLEGANRREEVQKTMQQMLKRLYDNTAKDVRYLVGDGIITLCDWARRTASTLLAWTPRLILDEAVQEARKHPRSPITSGSMSVQRRNEASDKLIHQVASTPSTQHQPGGTRDNELEEILQKACKSWEDVRLADFLAQEYGKTYGARDPNVTVATFLENPSHYIEEDAEREEVVEKLPEKPHHLRGCILRDVTFLRAEGITTRGQWAYRRFYPEVLIPVTNCILLRACGSPLDGGTNMENALTVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X3</accession>
    <name>F9W3X3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_27910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000489">
        <property type="protein sequence ID" value="CCD11851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394668" evidence="10">
        <location>
            <begin position="23"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="488"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD11851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="841" mass="94001" checksum="BF1CE04B4A035736" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W426</accession>
    <name>F9W426_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_28450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000507">
        <property type="protein sequence ID" value="CCD11909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28450"/>
    <dbReference type="OMA" id="CCKSCGF"/>
    <dbReference type="OrthoDB" id="865289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018593945" evidence="2">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="91"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37137" checksum="08BD2A53351A9FFD" modified="2011-10-19" version="1">MRAFVVVLSSFAAALVALGASALLAKDAPVLTKTFVDRINQLNGGMWKAVYDGKMQNLTFSEAKRLTGAFSRKTSTLPPARFTEEQLRTDLPESFDAAEHWPHCPTIREIADQSACRASWAVATASAISDRYCTVGKGKQLRISAADLMACCKDCGGGCEGGYPDAAWEYYVSHGIASSQCQPYPFPRCEHRGAQGKKTPCSKYKFVTPQCNATCTDKTIPLIKYRGNHSYEVRGEEDYKRELYFNGPFVVRFQVHSDFLAYKNGVYQHVAGNFLGGKAVRIVGWGKLNGTPYWKVANSWDTDWGMNGYFLILRGDNECNIEHLGFAGTPDPSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W440</accession>
    <name>F9W440_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28590"/>
    <dbReference type="OMA" id="PQCFIPY"/>
    <dbReference type="OrthoDB" id="1687169at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="283" mass="32949" checksum="B47C138FEBB32BAA" modified="2011-10-19" version="1">MVGPPSTPGGNAGPGYTSSLKTETAPLGGLSKRGEEGHRKYFTQKLPSKKNFIFFKNNPLFERISGSFRIPLFCQIPFFLPNSLFCQISIFCQIPFFAKFPFLPKSPFLPNSPFCQIPLFAKFPFLPNFPFFRQIPFFTKFPFFQNSLFLPNSLFAKFPFLPNSSFHEIPFFPKFPFLPNSLFCPIPFFCQIPFFAKFPFSQNSLFFTKFPFLPNSLFCQIPLFTKFPFLPNSPFCQIPFLPNSLFYQIPFFAKFHFFFQISLFCQISLFCQFPFFAKSPFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W446</accession>
    <name>F9W446_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="104" mass="12035" checksum="5AA18A9FEA619B97" modified="2011-10-19" version="1">MKEHPFHPSIALLLSLSPFPRIHPLLLLSIPRWSPFSYPADLPWSALSPCLASTEPLRLTGPSLRWSRKNNTMVHVFRTHTFTGRRWPASLQVSDYEIAKEEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W475</accession>
    <name>F9W475_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000525">
        <property type="protein sequence ID" value="CCD11963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28960"/>
    <dbReference type="OrthoDB" id="1375966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30817" checksum="3F821C08BB24038D" modified="2011-10-19" version="1">MEMTLPKAVKRREGADAHADGYHVCQCYGHTSELPNYKEILKPYTLQGTYAKMKCACPCIQKTKGKHVNSLYCSKRPATCDRVFPNETYRAHGPGPHKVHREVNTSADGAPVRDPATGTRLVFPNASNYGGTAKQRTFPVIGAPRRLTVSERKYENQYDRKEFLKAVLRDEICDRVEAEKRLDELENEIGLRGSRHARMLAEAAEAAKKAQSVESEDEPKTVGDQYNMVMDELRFVAQQPVGSKLNIVRMYYTVEEQEYVDSLGRKATGTVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4B0</accession>
    <name>F9W4B0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_29240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000536">
        <property type="protein sequence ID" value="CCD11999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29240"/>
    <dbReference type="OrthoDB" id="1668988at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="47"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD11999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="44886" checksum="724B75D094D7B417" modified="2011-10-19" version="1">MHKVTNKVEQGLTVMVMELRSKWWWLVASSVFMAWSSAFGEGDTPKAIPTKAGAAICTLSKTLKDVTPWATQQVEEGSAKVTNLEMKLLEWQTKWVQSKAQGKGSEACKMTGLLFRQVRKEIDKVREEVERLEREASKAAAFAANSAGRLDEFITVFANAKGESNGFCLGDTNAAKPEDLRDCFSKTDFSEESLVDIGERASAQEPNLFSRIESIKYSFLSSHFTAGSGGGCNLVKGASGGILGKTDLEKSLWWGGGILTIGKAFDGVLNRENFTAGEIRNAENGGSKAFWTADPATQIVHLKNTSDAFKAFKAVKEKIQEKVKSIEDKMEGCLTGQEPGQNKTEPNATEPTTTTEETTTSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPTTRFLGLLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R0</accession>
    <name>F9W4R0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_30680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000593">
        <property type="protein sequence ID" value="CCD12155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30680"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394552" evidence="4">
        <location>
            <begin position="24"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="48"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24035" checksum="5E0FF3A6BC93A2D2" modified="2011-10-19" version="1" fragment="single">MVCSGMRGLMTVLLMIGVTFVDGGGKHYNNAEHDLLCDVLKAAVGLWQNRENRNGLLGRALAQTIFGTRDRVEDVTNIKFPSVYTSPDYRLDWCGDCDDPSGPYPGRSISHDLICLCTVGGGGAPFNFGAETLCGKKQGDLVCEGCTEPFHLAGGRDHGWDGNQSGKQQLQNTWNKIVLACLTNGTNGNLKAALDNFTSSLGGKKQLGGQGGNCGGDNAVNICVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V7</accession>
    <name>F9W4V7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1238</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000617">
        <property type="protein sequence ID" value="CCD12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31080"/>
    <dbReference type="OrthoDB" id="407203at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="521" mass="60861" checksum="9C4F7DA7F635EB51" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Y6</accession>
    <name>F9W4Y6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000632">
        <property type="protein sequence ID" value="CCD12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31340"/>
    <dbReference type="OMA" id="HYEAEWL"/>
    <dbReference type="OrthoDB" id="1667299at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45601" checksum="BE55D356425C2947" modified="2011-10-19" version="1" fragment="single">MTGGGVRRTRDEMEEETVAPIVQAEATARDEATAATLAAVRPVAVRREVVAVPTGRWTLDSSVEDVLMERYGGLDGMRLHDFLLEHFGETFGCPSVSMRAFIGNPSFFLRDESMLELVTNLSPYRAYVRAYEIYDAMRKGVDRLNTMGIYFLHQWESAAAANEVEDVDIHVRGKLNGALVNVRRNEETIRVGNAPSVKVIDGAYDSVFNARWSYVVMSDEYDKKWLGMGVVRVSEGEQPHLWSEAQADAPYDPEEPWGGDVVPGVSGKLVMAVLSSQKGWPYTLFNANTSKIVSADVLRKYKDVHNAHLHIRKENVRVWHIVKKGLDEWLTGVKSVHPFLVIGTPGIGKSFATGSVLLYQLLHYEAEWLKVVAYFVREKAYIFHREDRRVVYYKKQQAAGRNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W509</accession>
    <name>F9W509_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000642">
        <property type="protein sequence ID" value="CCD12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1643200at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="285" mass="30227" checksum="6132E121D481D995" modified="2011-10-19" version="1" fragment="single">MLSNSGRSTSSNGDVFEPPPIPRTRGPLLYEGVRLAGGPPRRTPTRCCSRLAGRAWHAASNTVPVSESVRRGSSVMITPRNQQASPHASAHSSVRAAACEEEDDDEMDVVPSTAPLPTPYPTALGTALGQPDSVSQELLFDDVDAESSRGLSPGMDATPHSRERNGVHGISEASEVSPEGTAREDHHEPTEMADAPCDKSLPKGNEISAVNSQPSGTTRVPHFLPTPCVFCIDLCMLQQEVNACARPVEAMADAGHKSRHLRASENALLAAVRDLETLVAEEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R7</accession>
    <name>F9W5R7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_33920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000755">
        <property type="protein sequence ID" value="CCD12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33920"/>
    <dbReference type="OMA" id="PVCRMKG"/>
    <dbReference type="OrthoDB" id="1550067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="23332" checksum="C01E026EBAC78ED2" modified="2011-10-19" version="1">MSGGGGNGGDPPPPQLSKNSRTFMKKKLEKRAKKGSNSGAGGSGLSNGARFVPRSWQCLKKFNCPVCRMKGSVRVEMNCKEAQAVVNCIYCIQLVPRPVDLPYPFTTSFVPRLENRADVFFKFNELYRGLEQQAASLDATGNALQGDVKSHEGGVLSVPVLKDEGDSQKSDLCEEGEEERISELHDGGGVDGETVEQADEIDDVHAFFGESDQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5T5</accession>
    <name>F9W5T5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1374</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000767">
        <property type="protein sequence ID" value="CCD12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34100"/>
    <dbReference type="OrthoDB" id="69022at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="522" mass="55687" checksum="76C227B39B1E8450" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5W0</accession>
    <name>F9W5W0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000784">
        <property type="protein sequence ID" value="CCD12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03490"/>
    <dbReference type="OrthoDB" id="50967at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="222" mass="24459" checksum="5318E7C18CA81FB2" modified="2011-10-19" version="1" fragment="single">MSTGATLAAKIHKNRQLRLLAAQRRHLTSRFKEIFSGARVQTSRLNTRYYESNVYYSLGTSCTLHLASASAESLLESEERAYGGTLSLTSTKASVRHMLQLVDSDIFAELDATLKSMNARVVVHLLRTPRNGNDDRAGVVRADAQFMATVTAELPLSDEEAAEQWMSPAPGKAFGDVFISRGVGRSPHDAIKRGLALALEKLDEYAVKELQSREAEARCFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Y0</accession>
    <name>F9W5Y0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000796">
        <property type="protein sequence ID" value="CCD12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34490"/>
    <dbReference type="OrthoDB" id="129632at199999999"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21186" checksum="F3BAF635230648DA" modified="2011-10-19" version="1">MSFYTITSPRTIPWSMERDVVEVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRQSATPLVKHFGPTETWKKWHWDSWKIYFDNDDTPLEAIHEEIWRRCRRPPPPPYQPCQGVVWVEAAPAFIQVPYSTVGYLVPIPLSPRAWCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I8</accession>
    <name>F9W6I8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1476</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000880">
        <property type="protein sequence ID" value="CCD12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36440"/>
    <dbReference type="OMA" id="RITNTGM"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012338931" evidence="1">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="22264" checksum="124A30AFE9953AFD" modified="2011-10-19" version="1" fragment="single">MVLFCLFQETHLASAECAALKVGGYQHVGQARTPHGGEVSILVRDGVGVEVGILEKEVPERATVTLRFSADVSLTIISAYFPRRADVSSESLDTLLGANGAMVIGADVNSHHVLWDPLRPSDDKGECIVGWCVQNDMRITNTGMATRRQPGTAALSSPDITLCRDCEISNWKFALSPVSDHHWISFDVFVAASLDVFAPSKLARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6K6</accession>
    <name>F9W6K6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000889">
        <property type="protein sequence ID" value="CCD12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36610"/>
    <dbReference type="OrthoDB" id="1697817at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="24741" checksum="DED22FC4DFBE7082" modified="2011-10-19" version="1">MDQPSTAPSSRISGRQMKCDTEGNKSVPSPHPQSSGWIDSNKWGLFTNMEHEDPYVSKGLQQIEDTWIVSSDGPPLSEQLVLVSGSGVSALLCQSDVTCSSGRRGVTLQQESMRASPYATNPQYLNPWAVKVFNPSGFSVMDQDSQKEGTPLPTSPPISKPTTPSNTGRRCAVWNGSYFHPLVPLFASSPHSQTRSGLSSPLLSQLEDSVWSHGSGTSDYFNFPTTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6K9</accession>
    <name>F9W6K9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000891">
        <property type="protein sequence ID" value="CCD12816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36640"/>
    <dbReference type="OrthoDB" id="1687258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30861" checksum="8F317A6C3E18E4A5" modified="2011-10-19" version="1">MYDAVFNAEWRYVARSDEYSGKWLVVSVLGMAPGEQPHLWSGVQADVRPEHKEPWEGDVVPCVKVKLVMAFLSSLKGWPCGLFQRNEVPDVSTLTEYDVTCDAYIRKEYLRVWHIVKEGLDQWMESGRVVLPLIVIGTSGIGKSFATGSLLLYQLLHYTLERLKVVAYVVEGRAYISYREERRVVHYEEQCLTVNKINHMICEGIEGYIIFDTGDGNSGVERLPCDWDVFLISSPDRKKLKRFEALRPQKTIPVYMSCYEDAMFMAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Q2</accession>
    <name>F9W6Q2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_37000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000911">
        <property type="protein sequence ID" value="CCD12859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37000"/>
    <dbReference type="OMA" id="THGTINA"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="857"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="900"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1241" mass="135985" checksum="09D5E02F2819D38F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6X7</accession>
    <name>F9W6X7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_37550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000945">
        <property type="protein sequence ID" value="CCD12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37550"/>
    <dbReference type="OrthoDB" id="1086710at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="PTHR12547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="37312" checksum="04876908EC56240F" modified="2011-10-19" version="1">MPAALSKPAKMMIMSDGQCEVQSSRSCSLSQSIVPCGSYTGSPSVAEMDEEGHAKVVLAERYKTKYCNNFVINGACPYDTRCMFAHSAEELRTAEMNIADGLITMEAIRRFQRLLHQVTRSSRFARLRPVRTSAPWAMVPAASIGPAAMPHAYHDLRQSSAKGICERAGCVAAATPMAGVRYTHNPYRCDILPLLSRLYSKLPDMFVVPCNRVPDSGSELAQLPEERLSERILDGDETVPAFTERANAQQEQLRCDSDARCHEALFLPESLPSDEPDVACTPDSGSEEVDGEVGDRSVCSSIGNESGDVHNSPTYASHFVKGSLRTVGRGVSEESSHTDLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W766</accession>
    <name>F9W766_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38470"/>
    <dbReference type="OrthoDB" id="1713126at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25307" checksum="D774E23AB6E40CB3" modified="2011-10-19" version="1">MTISAVHILLIVLLFLNLSSLVLLVFALVRYVMARLHRNDEQEDTREADTAVHRQHSVGNIAEHAGYYREAAYSTRSAAEWPFDYAANVPQWVMQEMPPARLAALERRGMPHRDVRYCVPLPALLQGDSAAGRLNNANAYRSDINAVHTDVFYAAGPHRARPRYASCLGAMVGEATDISSSDGSSGDDDSVATQPARCYIAAVALRTPPTPLSDAASFPSSPDSDVLLSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7F1</accession>
    <name>F9W7F1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1597</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001015">
        <property type="protein sequence ID" value="CCD13117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39020"/>
    <dbReference type="OMA" id="LREERNC"/>
    <dbReference type="OrthoDB" id="532774at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19796" checksum="D471A0A0C24A5076" modified="2011-10-19" version="1">MMDIVHDGFGFMLCFGDLAWVPFTYTLKTRFLAYNPVHVSPVVVGVSCLLTLVGYIIFRGSNNQKSQFRRNPKDEQNAGLRVLKTSSGKSLIISGYWGICRHPNYAGDWLMTLSWSLLTGFTSVVPYFQPLYFAALLIHRQLRDEEQMLGKYGAVDLKKFHNAVPYRLIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N1</accession>
    <name>F9W7N1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1634</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001058">
        <property type="protein sequence ID" value="CCD13202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39720"/>
    <dbReference type="OrthoDB" id="1710132at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20382" checksum="FADE9738B98E21B6" modified="2011-10-19" version="1">MCLHHLPRTRRFSQTKCLSSRLTWPASWCPSSACRTSGTRRLQHTRSSSRLNTASLTSRPLCPPLFSAATSSGASSTTMHFAEPGNTMCLVGHASVPHCSRHRTIPSQFACSPHTTPPLIRLYCEFREFSALVYLNHVPHHVDICLEQLLAHPACKQSPRIQCVVAVHGQQVAHGRVSDSKHAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W847</accession>
    <name>F9W847_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1705</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_41310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001136">
        <property type="protein sequence ID" value="CCD13374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41310"/>
    <dbReference type="OMA" id="DVGREQF"/>
    <dbReference type="OrthoDB" id="852060at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="SSF140111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0967">Endosome</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SB" evidence="5">
        <location>
            <begin position="320"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="460" mass="50404" checksum="B2C62A0F2A618EF8" modified="2011-10-19" version="1">MSEKELRTHSSTEVLARHYGPVVGAKVKKYIDEFMPYADNFSSISCSLINDDKQLLLAISCPIHVAPPKEILEAIPREGRMYPVRVEIIFPSTFPNEPPIVRLLMGGFRIGKVVKWVVKQQLRGIATDGTINLRELPLLQQTESPYSLLEILVALTEEFEENFPLVPEDPADLTPPCRSAGVTTATALDSGLDVGPSAGTARFAAASTSVVSPPVAAPALTTAANVVREMTLQRACDAIFSHLQYKAEGYLDMRAAAAEHLFKLSTTSGQLSTALTALERRKEELLQHMPAPGKIEQLTSALEQVENSMEERSKCIVPADDLQAHALELLGEIHASDDVLELLERSLREGQIACEEYIRRVMDVGRQQFESRFLFDRVTEAVNYAQGGSISLPPSRTVCADAGRTTANVYTAAEPRNVSEVTTQLCSEFPQVGPEIIKAVLDMTMGNLQDARVQIQAMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B8</accession>
    <name>F9W8B8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1725</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001159">
        <property type="protein sequence ID" value="CCD13450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41990"/>
    <dbReference type="OMA" id="WVAERCH"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="21913" checksum="D0E2190DCFDB4050" modified="2011-10-19" version="1">MDGMGKQHDATVLQLARRVHFNTTTPGGLKADAPEKDKKMHTMRRVARFRDFDYQVWTDGSVVLDVSSGAGALVFPKEGRREKVVLGAGSVAFSYWAKCVAMEAGLKRLVDVIELSKTHRTRAVALTNSLLLRMALSTGPAVVEDAILRRIWELMRLVRIRVSVNFQFVFSHCGVPRNEAADKTAKQGNTKPQMYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H5</accession>
    <name>F9W8H5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42530"/>
    <dbReference type="OrthoDB" id="1709784at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19515" checksum="C128D704C65C628E" modified="2011-10-19" version="1">MCWMKVLYSRMSFQDGEGVIFHWFTNTTCILALNPDDRKLHSIVLQEAQLGRLVPLRARVYCSGHISTSKDECVLRSSICMHLSAVMPGGGEKATFMPLTQQIPFVTRQAAARCAFYQSLRRIKCLFPLLLKISLSSGPLCRDEFPTTQAPVFVPSVGYRVTLRPLSYSGLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8U1</accession>
    <name>F9W8U1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1779</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001218">
        <property type="protein sequence ID" value="CCD13627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43650"/>
    <dbReference type="OrthoDB" id="1662834at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="268" mass="29572" checksum="2E676E81008CED93" modified="2011-10-19" version="1" fragment="single">MCWFRLFCSQGTSSGDVATDIIDRDPRWLHGIMFLLGSAKDINQSHVSGVIIEARENMRMVKEQMDNEVCEMERFLENLGDLHGFSEWKNSWRVVTRAVKFGTVSMFDVAEEEVERCLCEQKETTKAIQVAVCGLRESFEASRSDDDFGSIGVSIGAAASSDNQISDNGFTACVDISGYVKHYKCLGVTLKEALDMKGKSTRGVNGDDRITGSALKMMVREAADHTTQLADSLALLQGFRVGVVTYLSVIWTLFAHLEDIAVSNGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Z7</accession>
    <name>F9W8Z7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TCIL3000_0_44200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 11"/>
    <dbReference type="EMBL" id="CAEQ01001246">
        <property type="protein sequence ID" value="CCD13686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44200"/>
    <dbReference type="OMA" id="RGSIQNI"/>
    <dbReference type="OrthoDB" id="156716at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="12"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="808"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD13686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="842" mass="95964" checksum="80AAF5168D250588" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W990</accession>
    <name>F9W990_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1836</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001282">
        <property type="protein sequence ID" value="CCD13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44820"/>
    <dbReference type="OrthoDB" id="1658342at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="513" mass="55517" checksum="DDF9A90704820314" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9A6</accession>
    <name>F9W9A6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001289">
        <property type="protein sequence ID" value="CCD13799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44960"/>
    <dbReference type="OrthoDB" id="683389at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21675" checksum="5AEEDDD66AEF494A" modified="2011-10-19" version="1" fragment="single">MSRRLLFNKGQFGEHDYNLLRTGAIATSRSVLSRNELIEEGIVDVGEGAVANVYERLMARLEQHGLRRVFISSYNQDVDCDDTRSRSDLDGGCDGPFDTPGEHKNQKSQNFGGGERVPYYYMCVPCELQLCETSEVPATLKMLQDAHYHFSSAEHRCIASWMGDQDIDLTLSTTAQLDPEGYSRIYVNGIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T9</accession>
    <name>F9W9T9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001349">
        <property type="protein sequence ID" value="CCD13994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46780"/>
    <dbReference type="OrthoDB" id="1676220at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388882" evidence="1">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43141" checksum="55147EB21B5D65BD" modified="2011-10-19" version="1">MMAGEVRLVFQLLAVVFLLCSEFTWGNKRQAIPTEVGESICSLSRKLKRVATWVVVQIAALKKSRDEYASKFLDWKLHFQGSSECEVNESILDEIWVTLENVNEEIKTLPAKAIRSGALAARSAGRLDEFITVFANARKTGSVFVATEPKTSNYCLGSGGYQAKRRDLFDCFPTGGKVEMGEANLAKIPETMTDLSEPNLTAVIENINHSSVAEHINRKYVIDAKAGCNLIKGGAEGIVGGINGPLWWGGGIFTIGKGFDGSLGVKDKFGPGEITNAKGSDSNKAFWTASPHTIPHLKKTLAAFQAFKDAAATITQKFSEIEKIEKKIEPCLSNETMEDRPTQSCFKNAVKLNAELQAANALLARYHKEKGPLPSGSPSPHAQGVMHLLHLISFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAA5</accession>
    <name>F9WAA5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001409">
        <property type="protein sequence ID" value="CCD14161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48210"/>
    <dbReference type="OrthoDB" id="1670973at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394635" evidence="5">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="39321" checksum="CA081918E7C06D84" modified="2011-10-19" version="1">MMNVAKIMTVVGLVVMGVHADVATEKVSSKSGFDLLCEVMKLATGVWHAVGSNYEEFTDDKEEKKLNKNIDQLFFGERESEDGVGNLYLPSHFEGARPERSSLCGSKKGYNNIPPPYKSLASALLCLCVGAKGDNSNLCGLTDVGEVTWPDGDTSGRVKNVFDKVWGDYSIGGVREKCEAGDTSIENLEETKENLTAIIKELDTTLTNQDGMLCPEVNKCQSEPVSVNVTRKPAWMPTLKEISNHIPIILKSRREKPLIDPVTGPAGTTTNEYASELVPPTEPAPAPAWSKVQEEAPKQEIRKAPEEKSKPKQEQKKHTELQQSKEEDHNQIPELNETSGSFLKRQKWPLWAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAA7</accession>
    <name>F9WAA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1951</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_48240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001409">
        <property type="protein sequence ID" value="CCD14165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48240"/>
    <dbReference type="OrthoDB" id="1712373at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="66"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="21885" checksum="59358E3AE9C7493F" modified="2011-10-19" version="1">MVIAVTVVSCKNRYSGTPLNISKPIPPFLLSEEQDSYSLKKSKRKYRREGVVKMACLVNVIAVAILILLGFVSGQVEVAKDDNIEPFALLCRIYNVAKNPPINYVDLEEPSEIVKEIDALNASLVDLNGPNETDQVENSSGVQRKPTHTRETAVAQAMIKCISQKAHTILEHIRRVNATRDIESVKAEIAQVIFGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAE3</accession>
    <name>F9WAE3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_48510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001422">
        <property type="protein sequence ID" value="CCD14204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48510"/>
    <dbReference type="OrthoDB" id="624073at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23975" checksum="056403513D25494C" modified="2011-10-19" version="1">MPMGSILLRAFVFYLGFSILMLLAYRRYRDWLHDDGWKMAESYARHERLAELQRLRQEMNERIQEARAAAAGSHDRIESLRNPIIRPFSSEGVTDYNAVTTSKERELRALERVRRQRIEDKMMVKGWPSIPDEKGKLVVQAQYPPGVVFFEPHRTDDRLRQVANLHEGRARSESLQKEREAAGVGGEGGGAAVAEVIQVILNSVREEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ5</accession>
    <name>F9WAJ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49060"/>
    <dbReference type="OrthoDB" id="1707223at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20773" checksum="3D656C0D9893A2C5" modified="2011-10-19" version="1">MLDRLHDNAIKDVRYLVGDGIITLLDWALRGASTSLDRVPRGVLDEAIREASKHPRPAITSGSISMQSSNEESDKPTHQVAGTSSTQRRPGGTKDNEQEEILWRACQSWEGVRLVDFLTQEYGKTHEACDPNVTLAASLENPSHYIEKDAEREEVVEKLPEKLHHLKGCIFRDATFLRAIGITTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT6</accession>
    <name>F9WAT6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_00610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00610"/>
    <dbReference type="OMA" id="NDIIRHQ"/>
    <dbReference type="OrthoDB" id="1570520at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="PTHR22937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="239"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="289" mass="32048" checksum="A45301B198DC88C0" modified="2011-10-19" version="1">MSERSGSKRPRSDAHNNNRGDTGSSGAGPASVEQTPPLDPQLEPDMERLGVDESLRASLRSMSPNTRAEVMNDIIRNEAVEHIASVFAFPGMIPRLSGGRFPGSMTDEQSPESRESNAEEENDVFEMVSGQGETRSTFRRASAHRSGRGSQMLHHPSLRDLLVFFTNILPQQDPQMDRLNAFNQHIALRSMGVTQDIDEMTYEQLLELQERIGFVSKGMTPEQISQCTVEVPVPTEGGCAVCQCDWVETVDAAETTVELKACRHIFHRGCIDTWLSKSKNCPVCKQEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB14</accession>
    <name>F9WB14_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_50560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001517">
        <property type="protein sequence ID" value="CCD14442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50560"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394647" evidence="5">
        <location>
            <begin position="18"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="45"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36550" checksum="23F9930958CA0BF6" modified="2011-10-19" version="1">MKLWMVFLMGLWVPVNGDEKNHNGEDHHVLCGLLGVAVHKWKTTNNPTAKEALAQSIFGNTNGGDLDGLSKGLPPEYHKPGNRQNWCGTCADSNRKHYPGNSIPHDLLCLCTVGENGYPFIEHGSIKQLCGQNARELGCEQDAGNPKGCHNGNGHGWSDSKYDDQARKHLNATWNAVVTTCLGKELKHDVEKTRKTLLEKLKVGEYSSPVWARSHHRCSGVNGDVCVSYGSQCDREDNNNSPQWWWHLEKALTAPNLQPAQLNAAVFSDATIDPAESAPAGQAGSSTHKMPSSTSTTLTPDEPRNRLLSLSSKQEDGTSLTHPTCLLGAIVTLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB17</accession>
    <name>F9WB17_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isocitrate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="4">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_50590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="4"/>
    <dbReference type="EMBL" id="CAEQ01001518">
        <property type="protein sequence ID" value="CCD14446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50590"/>
    <dbReference type="OMA" id="PYLELNI"/>
    <dbReference type="OrthoDB" id="769322at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="10">
        <location>
            <begin position="2"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD14446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="34979" checksum="0361A9539AAB7514" modified="2011-10-19" version="1">MFFREPIVCKNVPRLVTTWKLPVVIGRHAYGDQYSATDDVVREPGIFEMRFVPSSGGEPKVYKVFDFKSGGVLMGMYNTDESIRDFAKSCFEFALARGWPLYLSTKNTILKHYDGRFKDIFAEMYASVYEAKFKARGIFYEHRLIDDMVAHCMRSEGGYVWACKNYDGDVQSDSLAQGFGSLGMMTSILMTPDGRTVEVEAAHGTVTRHFREYQKGNETSTNPVASIFAWTRALAHRAHVDNNVELLEFTKRLEDVIITTIESGSMTEDLVICIKGEGNVSRKDYLTTDEFIEVVSQRLQLLLQKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBG5</accession>
    <name>F9WBG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2106</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001581">
        <property type="protein sequence ID" value="CCD14598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52020"/>
    <dbReference type="OrthoDB" id="1765251at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="12715" checksum="06CDF8484BE7CDF5" modified="2011-10-19" version="1" fragment="single">MVSVERDVPILKCVVIKFESVLFPQPLVPPQNTTSARRCWTTACAARQRGSGATVMCFPRSSCVRSLGMHLSELCLVPIKGDPCLGAGKWFPPRNGRGLPGSSPTNERISSGEPTFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT2</accession>
    <name>F9WBT2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001624">
        <property type="protein sequence ID" value="CCD14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53110"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390125" evidence="5">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="45"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="36699" checksum="58B044DC6580A763" modified="2011-10-19" version="1">MCRRLPLFFFFGGVCGTDGTNKDAFDKLCAIVENMSALMEKHSVAKSSLEQALYGEDRMASFDKDGSVSTVHGCGFGSLGRSEYCSHMQGGGLTRNGNSCFSHSLLGTFLCLCTKGRTGDKDLCGLNNAGGGAGWTSWSGYEQGLFQKVWTKIKQKCIENNKTSAGTSVDLGSLENALNEIKQNTKPPNGKAGYVTLGGVTNTDGICGGARPGDACVTYTWPGNAANIPLAEKILEGINKTRTQRQTSSKDSTQTSDFLHQDDHGEASDNGPDGEQEGEGEEEEESAPNPDPQEPSKPSRPRRKRSTKKPTEQPVEPLRAILHDDGSFLPQPFWLLSAFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC97</accession>
    <name>F9WC97_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001688">
        <property type="protein sequence ID" value="CCD14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54600"/>
    <dbReference type="OMA" id="VMSFLET"/>
    <dbReference type="OrthoDB" id="1355029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="212"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="286" mass="30938" checksum="0497700D524F5ABC" modified="2011-10-19" version="1">MEAAALNQDVEAPTVVSGSGGDTAVVAANANSSKRLFDLLQDDSKERVVRILTAFRNLTLLEKESLAQEMGVTLPKPRDKQAATSAMSRQLTGPALEVRRRDRNYVAMSPSVSAALRVPGSSNAANRPPEAGLCSLVSEFLGDEPGYMTVPDPVEDDGAAANFQEKDLDDGLPPLLLRSRSYQALRLVRDDSVETDAPYTKSRVLNITGMPLADADLWEWFDVLDIARNGLVGVDAFLTCVRDLGRGFGTSDKVQAGFEAEARALATDGQLSFDKFAYLATRFSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCA0</accession>
    <name>F9WCA0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001689">
        <property type="protein sequence ID" value="CCD14893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54630"/>
    <dbReference type="OMA" id="DNWMNDK"/>
    <dbReference type="OrthoDB" id="1057390at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="27289" checksum="725D5B5F4F8340AF" modified="2011-10-19" version="1">MRRVRAAAALTGFCRCFDSTTRFGKELGFSHKMRDIPVLTGNPRPVAREEEWSCRYKLTDRMEDVVRDVLQKAGWNELELKREMDEIFERKTHGSRSSLNTWTTVEEFQRTPWYRRYKPTDTCVAKYISYEVIKALEEALIPPSLRGDPYAHLRRRHMEDNWMNDRFSEETAKYIRREDLSKHTKGLPEYGQVTRRKFLEFDRMFKEAHGARQHVNEAYSAWLQSIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCA5</accession>
    <name>F9WCA5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_54680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001693">
        <property type="protein sequence ID" value="CCD14898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54680"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390156" evidence="6">
        <location>
            <begin position="19"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="87"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46947" checksum="CCE2BF1EEE7775F7" modified="2011-10-19" version="1">MLMKFALVVLALCVGVKSQRPSSAEFNLFCRILEEAERMLADVKDYVYDESKDREILEEMGVLFNATTDNMDEFRKTLWVTKDFFKAHPPPTDAGNRKKAHREIGNLIDKGEKKIQDSRKVAEKVNEKMKEAKLSVAQGLYGENVTEVPKDEGNWTKVRNNTGSVFVSNTSAKESCGNESTTTGKTLFNDLFCLCVGEGGNEAKAPCNGDIVPPKNRGYGGKEGSWTQLKYGGGGSPALSLAESIKKIEEVCSKNKEDNLKRGMLGLLKEFEDMIEKGTKDPAMKKIFGHSGRRNKKEVTTCDGSGGSKGNGDEKGSENICVDYTRHFKDNKYEIPWHEKFKNYSTLMKQAKKLEDQILKNRADLLLLKSQAWVAYSREKDDEATNLDDMNVSNLFDATQPPSSFPSFPFLFPFLFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD3</accession>
    <name>F9WCD3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001702">
        <property type="protein sequence ID" value="CCD14926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54950"/>
    <dbReference type="OrthoDB" id="836599at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035267">
        <property type="entry name" value="PSMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="PTHR10758:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20571" checksum="BAD2E792EC10D0D2" modified="2011-10-19" version="1" fragment="single">MGPFFSSFFFLKKKGSTWHAAALFSPSFLFLSLQLIILFGVFLLCGCVREKKISEGKQQQHNCVRRSVMQGEGKLVTQQLHRSDGEGIEKQLGYLMNLYRALCVRHDEIGQEIVLNDILALLTVNHQHDLAERVISTCEITHDHRSNNQAARYFYYVGLTRALLLDYVGANQCLQHALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCL0</accession>
    <name>F9WCL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_55700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001736">
        <property type="protein sequence ID" value="CCD15004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55700"/>
    <dbReference type="OrthoDB" id="1665688at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390149" evidence="5">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="96"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="423" mass="46588" checksum="D1120CDBE65C2A5C" modified="2011-10-19" version="1">MACFPNLLLLCFVICSFVKDVVGQNNAQVQANDNAEQFALLCRIYNVAKNPPINHVDFQDPNKIMNEIDILNASFAEEKWMNETENVENSSVAQVKPTTTREAAVPQAMLSRITQKAHNILDEIRKNNVSEEIEKVKAELSHVIFGAGGAESDLCNGSLKDVTGRGAACGNSGLHAKGQSAGNNLVVDFFCLCAQRNDDGIHDACKVKVGSKSEKHSWGDKAPSGSSSMWASIKKECENLLHQHPKSAKEGHEVIDDFWNHLKSGGLYRWGNTRKVDGSERKPGMLGTGAGTEGSGGKDVVCDGRRGYTATRGSGTPPGGICVYYGQEPQWEENIEWLKKLKTAMNTVDVLNNKTATIKRDIEKLHMLLHRAEKVYESAKLITEIQQPVLPTNLQTTAKRLTAYSASRRHHPNTHFFSLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP1</accession>
    <name>F9WCP1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001747">
        <property type="protein sequence ID" value="CCD15036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="14171" checksum="B71D368FCC5E21CA" modified="2011-10-19" version="1">MRRLGEGNFSDFVACDGSPNRGVCVMYYTTFPPPPWWKVLDDALKEDEKLQKQREEEERSKQREQDKNQDSDKAGTLKSTNTITNQTEASQKHNITDKLRKLNITSGTPISMPSSWLLSAAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCW4</accession>
    <name>F9WCW4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2285</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001781">
        <property type="protein sequence ID" value="CCD15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56720"/>
    <dbReference type="OMA" id="KVEYSVF"/>
    <dbReference type="OrthoDB" id="1564879at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="26469" checksum="6C0C6B0282B50855" modified="2011-10-19" version="1">MSNISEVHISGVALSHLLSPLTALPSASRKTYALYGHYGIRECDSDTTEKSPLVEAVVRVVAPADAVQPENTQFIGFASLRKSSPHKLSYQDMKLLRDTGPARMAVQGILQPYPAFLLLATVPLETHSTKSTRKVEYSVFGSSSNTSKAAPTYTADKAIPLKVDNMVDSFSPFVRLGDLGIHGYISKDDQVEEQKSPSVSELKFLSSLCRLEEATEEKDNLLKRIHELEKILTNSRDTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD00</accession>
    <name>F9WD00_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_57080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001798">
        <property type="protein sequence ID" value="CCD15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57080"/>
    <dbReference type="OrthoDB" id="1760589at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="21610" checksum="16FC4F1FE29D3F07" modified="2011-10-19" version="1">MRLSLAILLLLLFIYLFIYLFIYLFIYLFIYLFIYLLLFRLLFLTLWATQCLTSYIPIIFPSTVVFVFVYLRAYLFRRAIGWDCAASWPHSQPTKKKKEDKERERKRKRKMKRVACINAHIDSRIKLTYDWHWISIPFLRHVSLALLRKKEERKEKCAPASYVGVFSSRREASARLQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD19</accession>
    <name>F9WD19_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 13">O-phosphoseryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="6 13">2.9.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 13">Selenocysteine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 13">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 13">Sep-tRNA:Sec-tRNA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TCIL3000_0_57180</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">IL3000</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>H2O + O-phospho-L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:25041"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="Rhea" id="RHEA-COMP:9947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78551"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the SepSecS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.2" evidence="6 13"/>
    <dbReference type="EMBL" id="CAEQ01001807">
        <property type="protein sequence ID" value="CCD15167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57180"/>
    <dbReference type="OMA" id="MDTNNFA"/>
    <dbReference type="OrthoDB" id="680116at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00898"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098621">
        <property type="term" value="F:phosphoseryl-selenocysteinyl-tRNA selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019872">
        <property type="entry name" value="Sec-tRNA_Se_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008829">
        <property type="entry name" value="SepSecS/SepCysS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12944">
        <property type="entry name" value="PTHR12944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05889">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017689">
        <property type="entry name" value="SepSecS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0711">Selenium</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>tRNA</name>
            <dbReference type="ChEBI" id="CHEBI:17843"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="May act as a substrate filter by repelling compounds with a negatively charged alpha-carboxylate" evidence="15">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR017689-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CCD15167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="550" mass="59901" checksum="C618409C7D422774" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD73</accession>
    <name>F9WD73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001832">
        <property type="protein sequence ID" value="CCD15224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57680"/>
    <dbReference type="OrthoDB" id="1674269at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="297" mass="33825" checksum="36641C23649531A9" modified="2011-10-19" version="1">MSFLVFRHPARCKTVFATIISCFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMSVSFLVFRHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVIFSFPSPGALQNCFCNNYFMFRVIFSFPSPGALQNCFCNNYFVSFLVFHHPARCKTVFATIISCVSFLVFHHPARCKTVFATIISRVIFSFPSPGALQNCFCNNYFVSFLVFHHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD92</accession>
    <name>F9WD92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001839">
        <property type="protein sequence ID" value="CCD15243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57850"/>
    <dbReference type="OrthoDB" id="1700201at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="23625" checksum="C2B840137A0F7E6C" modified="2011-10-19" version="1">MLSTFFFPIPISPFSDSCIKIPMSLYTITSPRTIPWSMEKDVVDVLLDGVTSADRVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPAANVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDNDDMPLEAIDEEIWRRCRRPPPVPQYQPCQGVVWVEAAPAFIQVPYPAVGYLVPIPISPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEE0</accession>
    <name>F9WEE0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bardet-Biedl syndrome 4 protein homolog (BBS4-like protein 4), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_06650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BBS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001996">
        <property type="protein sequence ID" value="CCD15647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06650"/>
    <dbReference type="OrthoDB" id="609083at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028786">
        <property type="entry name" value="BBS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44186">
        <property type="entry name" value="PTHR44186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22615" checksum="0F8DB96FE9AF5D2D" modified="2011-10-19" version="1" fragment="single">MDGKVHDGASHQQPELDPENIVGAGGECTSAVKSGGALCSEVREHRNWLIYELYVRQEHAECLNVINEQLEEYGDVCEYALFVKGLLSRRTGELTASLEHFSKVLELSPMNPHYLRQVGQAQFLLRKYSEAIEKLQQAEQAREAQGLRKDWSLQYGIGLCYEYSKEYRKAEEAFRNSLRIQQFDCTVIRLSNILTIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEG4</accession>
    <name>F9WEG4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002006">
        <property type="protein sequence ID" value="CCD15672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MYNATIV"/>
    <dbReference type="OrthoDB" id="1428593at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="414" mass="46173" checksum="4ABA92866146714B" modified="2011-10-19" version="1" fragment="single">MREEVLSSAQRIQLLRERLEMYNATIVEAMNVVAGTNNSAEEGISPAASDSRTPPPSSRRVSGTQGVSSLLRTNRNQTNKSHNSDPSSHAERGAVRDLDSASPFGADPRRSERRTAPPPPPSPPGPGQQFLASQSTSFSSEDLNDESSATFTDSQELFEDICVGSSTPSERREHSPGFDQPTEGRQSPILAPITTVCREGNDGTTDSHGKSWTSYYVKSQENKMSEESTRSAVHPRGEVVALDNNSDLMEVAVSEAPTPTPLSETASFTTLESTLYRMLFFEQSLNKLLSTIDIDNFPQCLPQQQKGLKLAAVRDGLIEEERALREKHNELSLSELRENDALVISDQIRRLLSECECTKWLFQRVFERKANVAEKSKLLQRRIAERDNKQKRVAENRETLAALERQVEEQERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEP3</accession>
    <name>F9WEP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 296</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002044">
        <property type="protein sequence ID" value="CCD15754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07650"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22438" checksum="9CBFAA592C521908" modified="2011-10-19" version="1">MVTGVERQVRNEMHRSFEEGRMLRTHRRVLLDHIRPAPKHTKLDRLGESLLAQLRTGTSKHFGWLHRVLTRKTDRLECRWCKVKDNGGNAVERHTLAKSAVDSVNVQEFGIATRLSDPIICPLCNMVCARRQAGVVHLIKIRGLERECALAMTKKAGRTIQTHKNGCTCLVCGDAFERRGLLVEHMAQHPPDGILDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF10</accession>
    <name>F9WF10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08700"/>
    <dbReference type="OMA" id="DISTAGW"/>
    <dbReference type="OrthoDB" id="1611900at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="24733" checksum="3BA9915324AD06F5" modified="2011-10-19" version="1">MFPHPRPLGAPVDLGNCAPVAPFDMSWPEHPWMEGEEGLMVGSVGHRRKSFCGPRTEEEWEELMSRRDCARTESGHGRGSVQMGVSGTALGSGVSTPNDSGCEVLRDYYGDMAGRDGSARRSSQNSMGGRRVLGGRTASMSRSNASRERSSYGSLSSRRQKVMKEGGKWGNNPEEYLPANPTDLMDAAHSLFGGMYEGMEGPQEVCVLRQTDTQLYDTGRAFDTGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF81</accession>
    <name>F9WF81_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 359</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002114">
        <property type="protein sequence ID" value="CCD15949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09350"/>
    <dbReference type="OrthoDB" id="1710998at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19450" checksum="076A576390F20818" modified="2011-10-19" version="1">MYIKGGEHHREGRRAEWSGVEEPWSSSGDTRTVNKYKRGFLMEKKPNIYRTRQSSHNYFRGIKQKKNQMEYVRFVCRLYHPKCGPSCPSIAEYGNPGLTIATAGYHCRLLFSYAHSSKKDPPKKKNLWFTFNPGPTLPGKRKTQKKILTFSQYLPLRPQVCVISFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH0</accession>
    <name>F9WFH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002143">
        <property type="protein sequence ID" value="CCD16041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10090"/>
    <dbReference type="OrthoDB" id="1670035at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390260" evidence="2">
        <location>
            <begin position="27"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="43799" checksum="34CEADFCB49EEDAC" modified="2011-10-19" version="1">MESRRIGKGILAMLLAMIMVMNGVRGGDFGNYGTGYNFNGKHHDVLCEALKASADLWNASRTSDLRLERGLEKALGEALFGNHGKKDLAAITEVLPSGYNSPKHRGMWCGRCRQKEEKHYYPGSSITHDLMCLCTSGKFGEPFYSWWWNFFLFRYGFSTTSYKLCGKKREELVKDQSDGWFDDGEKKGSKGLDKSWKTVVWGCFDSRNKNDGIGSLDLREKVARLIETMKNFTNTLKHSKGRHKLGGFDGHDTESDGSDEKSMHVWYHDCERVRKPWWKKLNASLTSKPEGQLLVSRSAPSPAAGAGAEPQDDQEQREEDDIVTQGDPHQVGETSADGIDGNQTPGTTNNANSTVGMLNTSASGNSSHPRFEYLRSGSHISQSLLFLSAMFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFJ2</accession>
    <name>F9WFJ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_01240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002152">
        <property type="protein sequence ID" value="CCD16066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01240"/>
    <dbReference type="OrthoDB" id="1235745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="9"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1445" mass="162206" checksum="6AB4FDA3C0D382B1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK6</accession>
    <name>F9WFK6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10450"/>
    <dbReference type="OMA" id="ACAVRLH"/>
    <dbReference type="OrthoDB" id="1100568at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="728" mass="78633" checksum="01DDF4BD6AE0094C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU5</accession>
    <name>F9WFU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002185">
        <property type="protein sequence ID" value="CCD16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01380"/>
    <dbReference type="OMA" id="WAILHEI"/>
    <dbReference type="OrthoDB" id="1554256at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="475" mass="52093" checksum="DA6C1ACAA2756663" modified="2011-10-19" version="1">MTNNERPSNDVRLYRTPQQGEKERNEKQQQVQNLQLPYKTGREVTDAPKIFQMTHKEGEEKGNLPSGMTPAPSVEPGARWGNSHGLYDSQWENTYKFSGAKAAATAAFEQAAAEERSNDSCRDVRAKLLPSESADSGSLQRLSSAEEYSCTRRNVTLLPRFQAYEIRETRRISPKREPAFSATVVYASRGTPSPKRSVSSGVRTPSGETGQESCQRATPRTVGGPLARGSAEEQEVGSRRASTTPRSVMMRDEATTTEASLLRESAASQSPYPVMPKKSMHDASTMTGESFEGVALLAGQDNSTMALQSGPYDTEYFNAGRRHKSFANESLISLSTVSNSTYNQRRDLSTSCPGEGSPSHVAQHAPRTTVNDACNQARPTNTRPPLLPQPIERQRAHAASSYGSWNDGDDGRPNRAAVCGRPPMVPCRQEEQGSRAPPDVWAAKLRELDQAYVSSSNGWAILHEIRLILEGRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG31</accession>
    <name>F9WG31_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 460</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002225">
        <property type="protein sequence ID" value="CCD16261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12090"/>
    <dbReference type="OrthoDB" id="1460513at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="44174" checksum="C435B5F8C8D293CF" modified="2011-10-19" version="1">MSDEERTKWLRRSYTRSIPTTLRSLKQLEESAADAEAQWHELAKSLVSTTEGEGEGEREEEVPMEIRREISRKAEAFASQLKAVMQELTAQMGRAANLGLDTQTFEQYCVWAAATSQSSLSDVGLVDEDRRSCELLARVCMLCLCVSVVIGDLKLLVSTMSFAESHRLVERYTRDISYCGNGGCNGILRSNVACTFFLGCPHDGATRLPDGDVLSACILLYCLFTQSGKAATIATSLTAQEASLHALETASESEGVPDSSALYRMSFLHTVLQMLSWVEGEDFPRIHRCLVGGFHTEDGTRVPLPPLISLFISVMLHMVVRRRLVDARLHDAFRPVINVEAPAGGDGGRSVRVQAPYSLGELYDSCCGRFLGLCFAIQRDCMSVSGPWPLPTTVYEKLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG95</accession>
    <name>F9WG95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_12680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12680"/>
    <dbReference type="OrthoDB" id="1712197at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="26472" checksum="636855396E239FB7" modified="2011-10-19" version="1">MASDTSFATKTYVCVTCFILDVCAYWAVETRFLAPIFMASHYKYITGNEHAEPSSVLFWLNIFTFHNLILFAARALAERPELERLVRGWGLRLRFTLSIVLILAELALILFLPVLSMSPPYAIVSLCFTTILGTIGKQFLGRTTHTLWDFLLTEKAGGVIRLTAFLVAIVHATLCIIVVVPGTTGESRENTLSLHTVVYAVVLVIALVMALSLSLIRCKGEGFRSAQLAAHINGVEGINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD7</accession>
    <name>F9WGD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14598" checksum="4B6A68A54CFFF6DD" modified="2011-10-19" version="1">MPGDASKPPSYRLGEGDFSDSACNGNKQVCVMYYPNATRIKTWWVDLYHALEVEEAEKQKSKEEKAAKGNQEEEEAEVARMEPLRSPTQPTNQTEQHNENNLSAQFSRLNINSGTPTTQLLWLLSAAIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE1</accession>
    <name>F9WGE1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395021" evidence="5">
        <location>
            <begin position="21"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="102"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="510"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="582"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="918" mass="101079" checksum="215F4FC5C1391E01" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGK0</accession>
    <name>F9WGK0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 508</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_13590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002279">
        <property type="protein sequence ID" value="CCD16437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13590"/>
    <dbReference type="OMA" id="RCELRES"/>
    <dbReference type="OrthoDB" id="681139at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="212"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="724" mass="80378" checksum="8F124C4A0CA621E2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGK6</accession>
    <name>F9WGK6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 512</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002283">
        <property type="protein sequence ID" value="CCD16443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13650"/>
    <dbReference type="OrthoDB" id="426117at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="318" mass="35148" checksum="3B8006FF1A4A4E6D" modified="2011-10-19" version="1">MRTGGEVYVWQVMFLLLRRSHGFELAVRHEAELRTLLGRKGPEVDVSPCVAAALATIRWMVEGEVVRHRVFRTPTMAQIPLEEWSRCSSENIPLRAFILCSAELRTRWCKPVQDNDMLSAVPLLVAWVSDIIVQEYGTVAAARLCYVFLKDFPHLSSLVEFLGIFLMALGEEPVGLRGNGAMPCRGVAERAWLFASFLSAWPPWAEASGLKTAVDGFLSELGNVSSQMSCDGAGRLRESPPSASDLLVNKFQPSADVCCAVQALVEACESQSKHCGPFPLSRAKDFFLQRPVDKGAVDIRKDVVFRAVSEDCELIIVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGL0</accession>
    <name>F9WGL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002285">
        <property type="protein sequence ID" value="CCD16447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01620"/>
    <dbReference type="OrthoDB" id="101142at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1462" mass="162059" checksum="D96663AF45305667" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGP2</accession>
    <name>F9WGP2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 524</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13980"/>
    <dbReference type="OMA" id="MNIMPSF"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="66"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="471" mass="49794" checksum="7F8539C771922298" modified="2011-10-19" version="1">MSSAAPNPVPAGTEPVELTAVGYKGNDEQRHDTNPTPKPEDGRENASFFAKAGAFVAANAVPPGGIGASAFNIGSTTVGAGIFGLPAASQSSGLVMAMFYLLVITAMTVFSTYALGVAAERSKVNTYEGVARVLLGKWGAYITAAARVLYCFSGCVAYVISTGDILHATLKNSSASDFLKTTAGNRLLTFIMWLCCMLPLVIPRHIDSLRHASTVAFVLMIYMVAVVVVHSCMNGLPENIKSVSVGRNESAEVVLFNSGNTAIEGLGVFIFAYVFQVTAYEVYMDMKDRSVRKLVTATIIAMAMCLPMYALTALFGYLDFGSKATSSILLMYDPLNEPEVLIGYVGVLVMLFVSYALLGMSCRNALYSVAGWDANTVAFWKHCIAVVSLSVVMLVCGLFIPKINTVLGFAGSISGGILALIFPALFLMYSGGFTLQKVGPLCYIATYVLLLSGVIAAVFGTGATIYGVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGQ8</accession>
    <name>F9WGQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002305">
        <property type="protein sequence ID" value="CCD16495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14140"/>
    <dbReference type="OMA" id="MFPCLVQ"/>
    <dbReference type="OrthoDB" id="1588720at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18265" checksum="9C3A27C0BF542446" modified="2011-10-19" version="1">MKASSFIVQLRPGCFHLAVRAKPGARTTALAARPKIMDDASKLRGAAPPVDGKANTEFICFMQALWEQQLSTVRKTQTQQKSCPATGEEDAYSYQHYANNNNNKKEKVKKQGKKDSMAAVSQPNYADEKVRVTLVSGLTSRNKVLMVTFPGTEEDLLEALKSVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGR0</accession>
    <name>F9WGR0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_14160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002305">
        <property type="protein sequence ID" value="CCD16497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14160"/>
    <dbReference type="OMA" id="NISYTHM"/>
    <dbReference type="OrthoDB" id="1345916at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="6">
        <location>
            <begin position="63"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="25014" checksum="7D86E7891B67BD85" modified="2011-10-19" version="1" fragment="single">MCAAGHAPCGRTDIAAMLRDAQSITSKIISEAPELLHPPVEAAQCEWTRRYLEKAYNSILKIQAPMVRCSRPAFRKLCRLWGTNISYTHMIMADSFTRSEAARQAEFSIYSGETHLITQLTSTSGPTAAMAAAIVAPWSDAIDLNCGCPQRDVITEGLGAALLKRPDIVADTVRCVRNALEGGTELPCVVKMRVNDDVRLSVDFAPQCETAGAAWVTVHGRTPNCSSHAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS4</accession>
    <name>F9WGS4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 539</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002314">
        <property type="protein sequence ID" value="CCD16511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14290"/>
    <dbReference type="OrthoDB" id="699167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc-38" evidence="1">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="24294" checksum="E7A861D6B138B0C5" modified="2011-10-19" version="1">MTSVRRGTPRLFTGALLPEEVSNGLMAIAARHKLESNVWVPKRLVKVLREGATLLPNAVLCDILLIPGCGACDLDTLGGDRLLVNAVHTSHKMFFEKYRDDVAAGVHGAFPLTHGGVPYGTNRRDGLSLLAKKKGFKVPYWVKERNCSKARILNAEETPYQGRYNPVDCVMYEPHTLTNQSFPAPIAVLMRRKASRFGYVSRTWLTAEEGALFGTRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT0</accession>
    <name>F9WGT0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_14350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002317">
        <property type="protein sequence ID" value="CCD16517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14350"/>
    <dbReference type="OrthoDB" id="1669703at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390365" evidence="5">
        <location>
            <begin position="26"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="74"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="412" mass="44640" checksum="3678904F70B24CA8" modified="2011-10-19" version="1" fragment="single">MVLQTLLRIHNLLFLCLAVFGVMMGMPHDENIPQFKVFCTIFGLIKDPDQRIRFLNEQLAPTPESLLSEIEKLAVITSKTDDLTEERQKLQKIDQNWTAEEIVREDGLKAKKFPAVDPDLPQVRLAAKKIRRIMRKAEDVIREFRGKAQEVVRLDGGARTEFKKALSGDANGKISQSSFASRGGAGASTRRQDACSYNAGGTTEGPGKSLVNDVFCLCGSAGGSSSSEYSSACGQTMTETDVRWASSTGTDNALPANPETTFPTIMGKCPNQVGWDRPNLPSAAKLRRALADFDALLGKTNFAGSNPDRKAYHFGGGHGSTDGSCDGKTGDHQKVCVNYLKVMAGNGPGISWKAAIEKAAGELEESERLSVEMNNTKTQLELLAESAWGIYEGALTGYSEQSAPHPKESKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT6</accession>
    <name>F9WGT6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VSG_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_14400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002323">
        <property type="protein sequence ID" value="CCD16524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14389" checksum="63BCB211B9F08B71" modified="2011-10-19" version="1">MRDSRMRSHHEWTCLREASNVLVSLTLAYVLLATNLGEANLERGANRADFELLCRLYLTATEGHLLEPLRRKPEQGMELIRIIQVAMSPDDLYKAIEENKENETLTENLAKLEDIDQATXEGVGVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGU6</accession>
    <name>F9WGU6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 551</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002327">
        <property type="protein sequence ID" value="CCD16534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14500"/>
    <dbReference type="OMA" id="FVECFYG"/>
    <dbReference type="OrthoDB" id="856582at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="418" mass="45409" checksum="36BD3064187AD5FE" modified="2011-10-19" version="1">MPKVFRVCNDITRLALVDFLVDKRTRFLEHLRELSSGGSLWMGTVQITKEDVVQYFGTNGTSSSNSRGDDAGYLNCKCEALMPSGAVRYRIPSSRAPELRPTSSCAQSATNETEAETSEVVVTVEPITGTRQTASAKWISTFLPCYFCLAMSLGDLLQVGLPPNDFANCLHALLLEINVRFATGTTERRAAQSKLRDYRRQHCGHVDGLLASVALEGGRGGKSLYNRGTSGGSSSATSTSLLDGHPGGSLHGMPDMEEQSMYFFMDTGYQQYTDATHVSYEQVMAPLCAQLVLAYRSLGSYESASSLEKVRNILAIDRYLQHIFFVPLSGELSNIAHRKLLQEITLLSSAGLFSQFEGVKGNVGYLTRGLMRQASGLGLGGKASHRNTKSSGGRSQSQKSNVQTSGCDSEDFAAPVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGX2</accession>
    <name>F9WGX2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 565</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002343">
        <property type="protein sequence ID" value="CCD16560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14740"/>
    <dbReference type="OrthoDB" id="1693878at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="24511" checksum="A920454B01DE7C96" modified="2011-10-19" version="1">MTLRLPCVSHLGATAYSCGDMCKARSVVSILHTALEPPFYRYSILAAPFFHLVLEGRGIGQQVAQEMVSRADCPVIPAQLESTEKGRTHPGLNRGPFGLQPNALPLSYESSADRSWSACGLFYGTLTEAPKPECCFTSGHHYTRTTSAKGPPVLSSSSCIWSLSFTATSNVYPISRERREAPNDRHTLLSHCNQGSPGSYMARGSALRLAYVGSVGSHVRNLGLVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGX3</accession>
    <name>F9WGX3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 566</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_14750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002344">
        <property type="protein sequence ID" value="CCD16561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14750"/>
    <dbReference type="OrthoDB" id="1679295at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="321" mass="35630" checksum="1EB29049A1A3F20D" modified="2011-10-19" version="1">MKAALHKWNQIKGKEPANPLKKALEKTLFGKDDGGKIEDLKGVLTQDYEKVQGKLPLRLQWCGLPKEGDTGENNQRWPGHSATHDLFCLCTTGQEGYPFNVVGSGNSPATKLCGQPKDALGGGSDGWDSKHRPGETEHGKDQMTATWSSVTQKCLVEDSNGKGLNEALAAFLGKLEKKKPEGKHTDRYQLGEGNADEYPCSGNIKICVMYYNTTRANYPMPWWTELQSALAAEEEQKPNEPKENNHKKEDEKKHQKLEYQEQPQHQDAPHTAALTSAPQSSQEDEQDNTENIPNPIATLEEASSTHIIPPCPWLLSAILMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGZ9</accession>
    <name>F9WGZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_14980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002357">
        <property type="protein sequence ID" value="CCD16588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14980"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="72"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="376" mass="42306" checksum="2C98EE2B05485E45" modified="2011-10-19" version="1">MVVRFCVMGDIWVSFFMDCLFISRLVGKGIFMTGMKVMNVLIVVVVGVVSASDVSTNHNGEPHRALCDVMHAAAAKWKKIKNFDSPLKKALEKTIFGKHGGNVITPSELQMPGDYKKPENEDTKNTRKNWCGSCETEGQKHYSGESATHDLVCLCVPGQNMWPMKSQEETLCGKSKEAWTKDGDKEGWYTNIISEKDLKTQHLTATWGTIVKECLKEDGGKDLEAALKNFKDNLRQKNGNQYLGNHTDDYDCGGAYGYSLCVKYTQQCEKNSWWKKLEDAIKKDKEEMEKKNADGKKTESLENGQKLKVSNGPQTDPEKSSQNPQPISRVSQSPQTEEHEDPPRAEQVISNINATIEEDSSTIICPFWLLLVFLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ4</accession>
    <name>F9WHJ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 656</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002444">
        <property type="protein sequence ID" value="CCD16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16870"/>
    <dbReference type="OrthoDB" id="1714733at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20174" checksum="1AE9B69A28AFC10E" modified="2011-10-19" version="1">MIPQSTPWVIGLQLQNNTPIIFSLFHYAFTARAPPSPRFSSGTSPHSMEPLIGLWAFRKNFREIAFSRTLRPYLAVMRRRIGGWKNSDIRATPPLSRLFWGSIPLWGMWATRHSPVGIIPSEMLPATHAKAFSSLLQLVHSALLSLKPFSAEHSSLWVADSLHCLFGPLFLRPFQRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHL2</accession>
    <name>F9WHL2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002453">
        <property type="protein sequence ID" value="CCD16805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01800"/>
    <dbReference type="OrthoDB" id="1697586at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="234" mass="25631" checksum="45EEC35AB73C4780" modified="2011-10-19" version="1">MLAASAQTLVYQRILRESGFVTRSRPRVRNHKHCRSETGSKIESVSVKWRAPKKSKAYEGSQVSVCSCAYKAQWKEEMGNLTPTIRKCDQVTNIIVNAITTSGNYVCSHPNILNALEYGHPLEDIVVRVKAAGEKGAAIRSLVCNSELGNLNGNLISESNGGNGVLENSTGDVELRALEEDVDIGLDVDNPPNNARVSALGAWSPVGPVPFPVVFIEVVIFRLVRRWSQGDTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN7</accession>
    <name>F9WHN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_17210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002465">
        <property type="protein sequence ID" value="CCD16831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17210"/>
    <dbReference type="OrthoDB" id="1668123at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394781" evidence="2">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="385" mass="42573" checksum="E3C2DE93CC40D1C2" modified="2011-10-19" version="1">MLGLIYVGLLSITVLISGSASTTREDGNNGDSACKLNENATGLLCTIAKLVERARQFTANHEEKEGRDALADVEMYKEKLDYHSKLLEGLLEEAKQKGTLTEQDVNRLKSTADEAKRKNNDVHGKAHEVMKNYTHHHNRAKKSTKNAKGDTLIKGNCHSTASLLYVLQCHIEGKEHDHNEKNIDTICKGRDYSEHLTEHLGKLNDDCGGSKGKRYCSGTGTALKEALEKWDGMGTNDTTTGKRKAGNCTISSAWEKHALNARDHILELDHILETVHNASDQSFVHYSTVWQMREDIAKGKPMEEIVANARKAGQQGAEVVVEKSDSGTANETEKKSGNTTSPVEEEVKVTVQLDGLKFDEENLTANSKESFPKIYIYLLAILLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHT7</accession>
    <name>F9WHT7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 694</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002485">
        <property type="protein sequence ID" value="CCD16882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17660"/>
    <dbReference type="OrthoDB" id="1718621at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17912" checksum="A0721D6946A3DDAC" modified="2011-10-19" version="1">MSLWRQRLSKKMGIMKTRKVHINLLRIVPLPVVGCPFGAINLEDVKLHSFHFSFSRASNKCIGSDSALLRLSPNSSRCSKTTSRHLFALSLLPCDFSPNPDHHYHFKKLTPTRRLIKIYFWGVCVASNEFLLPRVFPKKGTPSTANHFINWKKHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHV2</accession>
    <name>F9WHV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17800"/>
    <dbReference type="OMA" id="INDSAYD"/>
    <dbReference type="OrthoDB" id="447572at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="1">
        <location>
            <begin position="280"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="41873" checksum="85C7DF4436851A59" modified="2011-10-19" version="1">MTEHFKTVKSMIASLRSEDPEARLNSMRGIHVIASTLGPERTRDELLPYLTDYLDENDEVLRVFANALGTMLQEVGGVSHVQSILGPLELLSSLDEVTVRDEAVSSLHNIGKAVFCESSEITAQARRDFVSLVQRLGQATPQCRSSATYLIGTAYAHVNNTVKTQLFSLFMSLCGDEEIMVRRSACIALGKHMTTVAESRTTEILNALAKFSRDASDGVRLQAVETAAALLAVIPQDLHGSVLNAFKTLVSDSSWRVRYMAADRFGKLAGGLAPAQVKQIMPLFRSLTQDSEPEIRASSVFNMASVLAVCPDVTSKREVLLGGCRLASDDNAHVRMCLASALLKSVEHTPMEMWTQHRCSHMQLSSCQPVRQTSASLWFQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHX3</accession>
    <name>F9WHX3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002494">
        <property type="protein sequence ID" value="CCD16918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1919666at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="14820" checksum="A742F875C6EE7684" modified="2011-10-19" version="1">MAVSFSPSFMSPIILQILVISPFLIITYLAAPCESRLNVLGNAPQSTTIASLSFGWGTKFSFRSCAIYPHLPAVTHTSRNATRSRSSGNMSQAKWSSQRSMGRACFMGSPPPTNLQSPAKNIRAGVCSAASSVSSVLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIA6</accession>
    <name>F9WIA6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 756</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002555">
        <property type="protein sequence ID" value="CCD17052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19090"/>
    <dbReference type="OrthoDB" id="194057at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="246" mass="28240" checksum="5B3D2CC87C4DB477" modified="2011-10-19" version="1">MMTEKHIHKMQSVSNFRGNVHVINVSYVQRARAYKEASAKKFICRWLHDCWQIRRAKRELESLRFAFKNSEKQRNEAAARIIQPVGRGAIARLRMRRILNSVLDDDDDANFTKVSVDFLDDAAINLESVGVSSVLQRVLQNRSLLPNFSVLASSSREVPSSSPLRTGSAVQLRAGSIGTDDEARNRPVSQPEVESTSAFNDGDEWGVLVSSQLEKRQKQMERARREKMRREFMNDPIRVKRELQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WID7</accession>
    <name>F9WID7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 771</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002571">
        <property type="protein sequence ID" value="CCD17084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19370"/>
    <dbReference type="OMA" id="EMWRKSE"/>
    <dbReference type="OrthoDB" id="1591260at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="29464" checksum="8D1EFF57F002B07B" modified="2011-10-19" version="1">MLSRTINLLRVSPFSLFMKDLKKKRELTGMTLAQGVRVASRMYRALRPAQRRALQSRANQLTYPALEAFNAFQRRESRHLIHLKNAQRQRIIGEMWRKSEQRKNLELKKLREKAKERREARLSLMKTKKKVGILPSVRKFRIKKVDDYGAREDVKSKISKRSRPSNKSNVTSKDKGAAALKEDARGREVQSSKTGSKDTGKDKKVRQVKKVVSERLANEMRRRAALARGLKDLLKDKREEKERKAMKGSARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIJ4</accession>
    <name>F9WIJ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 803</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002606">
        <property type="protein sequence ID" value="CCD17142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19890"/>
    <dbReference type="OrthoDB" id="217595at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45297" checksum="21DFAFA78A625FD6" modified="2011-10-19" version="1" fragment="single">MSWLQALGSMSRKAASLPKRRVSASTNTHRYRFAEPVGSVERIGGEFVSGAPEKDIGSSASALLRVSDSWQGALQLIQFSRSELKSVAQTHVRHSSPRTVAECVAVLLEAGKGLLALELLRAWVSNGRGSRGSLTFKRDVKHVITQRLRKSIETLGAIGDVETLRLFISFLHTSLLEQRKLSQYRWQKQCSAPRVISESEASRSDTHKGDGINILENSSLFLSMLGVRRIRLLLVSAVHELIIQECDVVPLSEKLTWINAVSMATPLPLDCVSCIIPCILQEDFQRHIEGNPSYNEQILRHIGPALCSGFRSLAECDVLEVLWMPRSELRWARRNNGTERLGSLWSCVKSDVLPQSEFMQNSLFVLSMVDFILNDTSPKKSIRRSHAKLLTLSFEQRELRKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK5</accession>
    <name>F9WIK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002610">
        <property type="protein sequence ID" value="CCD17153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15075" checksum="CEA22412E27C5C65" modified="2011-10-19" version="1">MASVNKGLQGQHCQKVHGQSTICFARGGPDREKCPAFYLALFQVNVCHGIASWCLTHRCLIGKVWERCRQRVTGVRQWNRCVGMRKGHRSVHGYAGTPKTKREETTCTTEAAVRISSGNRLYGTRARITTTLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ36</accession>
    <name>F9WJ36_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_21630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002678">
        <property type="protein sequence ID" value="CCD17337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21630"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="614"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="958" mass="106657" checksum="39AE1A40A9CAFA54" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD4</accession>
    <name>F9WJD4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002712">
        <property type="protein sequence ID" value="CCD17438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22570"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20190" checksum="32AB004E6EADDC10" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREKVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLRLDETDHDIMEGMVWAVCKMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJE3</accession>
    <name>F9WJE3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_22660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002716">
        <property type="protein sequence ID" value="CCD17447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22660"/>
    <dbReference type="OrthoDB" id="1663020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395111" evidence="4">
        <location>
            <begin position="24"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="79"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="427" mass="46895" checksum="F0BB749B8CBB3B00" modified="2011-10-19" version="1">MAYFVNVISVAVVICSFVKNTEAQGAQVQGVDNAEQFALLCRIYNVAKNPPINHVDFQDPNRIVNEIDALNASFAEEKQFKETEDVVNSSDAEVKPTITREAAVAQAILRRITRKAHTILEEIRKMNATMDIEKVKDGFDHVIFGEGINESNLCEGVLKNVNERDAACGSSGLSHKGSHAGENLVVDFFCLCAMRTDKAKEGIKEVCGVEVGGSKNNDHHGWGDKAPSGPSSMWASIKKGCGKLMHKHPISTENSHEILGEFLKHLEKGGQYRLGATERRGGTVKGSNRKEGMLGTAVGDEGKNGADLICDGSRGNGKGQPPAGICVYYGQESDWQTIRWLVKLKTALNTVDALNNQTATIQRCIEKLQMLLHRAEKIYETKKVITEVQHPVGLTALHNPTTKRLTAYSASRRHDTHAHFLSLWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJF1</accession>
    <name>F9WJF1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22740"/>
    <dbReference type="OrthoDB" id="1663441at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="416" mass="47764" checksum="B4938E4C2261F646" modified="2011-10-19" version="1">MVSFSLYLSCALSVKGCLVSRKMKDPWTMGMVLVMTVFIRGVRGVWTWNPHDKQGHNFNGEAHDALCKVFQASAELWEASQTPGKKLDNGLETGLLQALNQTLFGSSRVGTEQPLDGMNVTLPKEYHATSHRGDWCGKCNHGNTDLHPGSSIPHDLMCLCTPGYYSMPFYVWQWNFWYVRWDYRETNFTLCGRQRAEMVQDQYQGWYYWYKGYGQNEGLQKSWNAVVLGCYNNRTKPRRTEGHNLEEKIKKLSVAMREFTTLLKQSGGHDRLGGFEGHHTPSDGSDETSLHVLYDTCDGKRKPWWKILNETLHKNHPHELVLNRTPTTLHAIGASLQDRTKGEEVRAESMEDQERTSAQGGNATWGHALNSTQHRNTTWRERYEQEYRPYIQHLRSHSDRPSAKILIPVFAAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG1</accession>
    <name>F9WJG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002720">
        <property type="protein sequence ID" value="CCD17466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02470"/>
    <dbReference type="OrthoDB" id="38642at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="675" mass="74322" checksum="D0A1A52FFDB2D2EC" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK01</accession>
    <name>F9WK01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 974</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_24660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002796">
        <property type="protein sequence ID" value="CCD17662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24660"/>
    <dbReference type="OrthoDB" id="1672020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389239" evidence="4">
        <location>
            <begin position="20"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="24"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="39794" checksum="29E5F97FA1105382" modified="2011-10-19" version="1" fragment="single">MWKASTAVLLVGMLAVAQAGEFPVGKNYPYLNTLCRLLMTAKKPPIPVSLERPAENGAFPARIFMSALAEDEWYEEVSKAARVEDLKDGIKEKYKNYAEDWATWKAGVKELEKHKTIKKLDGNAPPVVIARAKLALIVANIKKIQEREAAFNNNSDRLEIGKTLIEAATGKKNLEKIDLGNLDPAVTTAGRSTACGTGAGGGTSGSDAGKAITNDMLCLCAAKHTGASPGADKEVCGKDIGGAGNGGADDGTISWTSSAVPQKALLQTITKACSEEKTPPAHGARELQALLGKFRGQVAGGANCQGSTAADGVPHGLGYWKHNGNTCTGSSLTCTGDAGANNQGPCVVYGLTGANENTIIWYGKFETALKAIEKLEGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK69</accession>
    <name>F9WK69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002818">
        <property type="protein sequence ID" value="CCD17730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25140"/>
    <dbReference type="OrthoDB" id="1506259at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="722" mass="79491" checksum="6443385F1AD5A25F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3C5</accession>
    <name>F9W3C5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 103</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000392">
        <property type="protein sequence ID" value="CCD11635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02850"/>
    <dbReference type="OMA" id="ANSAMES"/>
    <dbReference type="OrthoDB" id="1080999at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="233"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113090" checksum="87607850D0294349" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3J1</accession>
    <name>F9W3J1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_26630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000416">
        <property type="protein sequence ID" value="CCD11709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26630"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389752" evidence="5">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="261"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37371" checksum="6037E446788BD1B2" modified="2011-10-19" version="1">MFLVIVGMMMMALSGSSLGTGTSEHHNHNEDHHDALCGLLGAAVRKWKRTHNPTTKKVLAQAIFGNESGGNLNTLLAGLPETHHKPGNRHNWCGSCAYGGDHYPGKSIPHDMLCMCTVGEGGFPFLAYSDKPETKLCGKSAADLGCKNQQDSGNGCHSNQHWWTTSTKSHNGNGEAKVHLNVTWEKVVKPCLQGGHIGRAKKTLLEKLNVGEYSSPRWGWGHTNCGGDYSDVCVSYGHQCHDNPKSPQWWQELYEALTTTEDTHAKGKSTRSTRKRTRRNTGGSTAPEEEENDSEEDEPEDTGTESTNNHNRQLPLLSHQQSGTSLTQPHSWLLSGVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P6</accession>
    <name>F9W3P6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_27160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000448">
        <property type="protein sequence ID" value="CCD11769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27160"/>
    <dbReference type="OMA" id="YCELYSA"/>
    <dbReference type="OrthoDB" id="1407357at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="25270" checksum="1E192E10165AC8B3" modified="2011-10-19" version="1">MPLFGERQRSCLSRKTFMWLDLALTLFDNVTFIAKGDDDMYLRVPQQLANIRALPTRNLYYGYNMPGRYPFQFRYSDGSIFTLSRDLVQRIVAYPPLRRLATQTYDPGYLKHYMLLFMDHEDMMVGHTVFRVARNVTYATVRRCHFHNVYGRTDLSPLTLNSIMLHNIKERHYVELMRHFREIPPATTKFIETSDGIFFECELHSGSPLHLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3T6</accession>
    <name>F9W3T6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1107</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_27540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000470">
        <property type="protein sequence ID" value="CCD11810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27540"/>
    <dbReference type="OMA" id="GKVKCFT"/>
    <dbReference type="OrthoDB" id="1274194at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394542" evidence="2">
        <location>
            <begin position="21"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="3">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="25180" checksum="C30DABEE1D0FFD88" modified="2011-10-19" version="1">MKVLRLFLLLFCAVLPALRGAESFRFTSKPGKKCFTEEVPEAGRYHLYYKMTRSLTPFVAVSVTTADGRVVVEHHMARADAQEILDIKHERKLAICFTVSPKALHSASSFNITLELMDAQDAEFERQRRERRSTSNPAALGTAQSSGSLLQMHYIIDMATRIRFDFLSLISVDEDMRYSLNEVNAEAWNYVYLFAFISLLICTVTYARLRHFFKTKKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3T9</accession>
    <name>F9W3T9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000472">
        <property type="protein sequence ID" value="CCD11813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27570"/>
    <dbReference type="OMA" id="STAKWRQ"/>
    <dbReference type="OrthoDB" id="1162194at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="23101" checksum="457FD68CF2CD1246" modified="2011-10-19" version="1">MQSVLPYTLDPQRMTGCEKMRVIDPNNSSITGPLAVARALEVVTSGLLDQWEASAASAAIPSAEPDLRTWDLSWTVHEEHWEQNVAQCSAPEEVENLLPAKWFGYNLNSDVDETLAHVCKLCTALVDKFIAWSKNDMANTSTARWRRWQALCERLSAVVELLEESMGEAIPLLRLRDPEFVRECWGRLQEEERMEVVSVLDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3W1</accession>
    <name>F9W3W1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000483">
        <property type="protein sequence ID" value="CCD11837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27790"/>
    <dbReference type="OrthoDB" id="1077037at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17717" checksum="B5630BE32A58322C" modified="2011-10-19" version="1">MYLSITALREDAQDCWEHFSELVICWVELANGTSRRLYPPRSFALLLLVSDAILLGVWMASGISCLRKIGNVSTKQTFRRTYGVGAALLTLSITYSCMSVFSPLRYNAIVTVLLLVFRNMCDMMMVLLLTVQIGSPSKQVPWWVSWLKNVPVSESGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X0</accession>
    <name>F9W3X0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1121</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 209</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05470</name>
        <name evidence="1" type="ORF">TCIL3000_0_27880</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000486">
        <property type="protein sequence ID" value="CCD11848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001565">
        <property type="protein sequence ID" value="CCD14566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05470"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27880"/>
    <dbReference type="OMA" id="CTDLQEY"/>
    <dbReference type="OrthoDB" id="1030572at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="282" mass="31422" checksum="17C8D1069A2A8CC8" modified="2011-10-19" version="1">MFIFSHNKQFVKKKIMSVSCVISLALPSIRTLTDSIKYLTVQEDGVRIDLRGDERYAEVRLTCVGILQRSYLEVVLRNGVTEKRLEIGYGNDVHKEGFPIVVHGLLLSRVLRLFNGYEPVMLELGSDLTSVFLHTVDRERWARLGVHHDLGPLLTVAHDISVFHNIPSIPDFCHSVQVAGSSHGNMCSVVLAFDDMHCFIEFSAKDVKASVRIDGSRLQHRYEGQVGVLELSAFGEFVSRANDCATLSVGFGSSGLAAFQLKWNQPPSSRAESIAYLYFCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y7</accession>
    <name>F9W3Y7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1128</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000495">
        <property type="protein sequence ID" value="CCD11865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28040"/>
    <dbReference type="OrthoDB" id="317848at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="509" mass="58123" checksum="D60CBB6187510E18" modified="2011-10-19" version="1">MLQKKVLGTNANSSTVLVKDTAAGGELRVLKRINVSSWVDSDVEKALEMYNAIAASDIPHMVKIYTAVLQNTFLSIVSSYCPGEELQEYIEEKLTGPLDEVMALQWLWNVARVVQRVHSLPLCNRLLCFYGPLLDRIFVVEGGEDVVVGLPLPRVLYFKWLAERESFGVALHHEYPPEVLRGRCYYTPASDIWQLGLVGMRLLSANTSFDHRSPAACSLITSMMDPIMKKRPTIEEVISRLQDLLREGDVRSLSMPDIPNSPTSYDRFLTPKSMLMDERTAATSQEEEFECLTTDISKLNEDHIYGAQRRAWRTRVQPSWYRRAMRQFEELQIMNSSPLVSRSRPSSPIQSGSTIFSPRGIADRKVATARDMQSESRAFRRQAVPALALGRNTKPRVTERAPNSARRVPKSYTSPNDSLAASARRPQKQDFGEKKRRLQAMEREAYAMHRVHENRMREIRQSQDDVMKHDIRRYIKQWREQSSTVKDDSISFTEQDGVAIFFPKVSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z4</accession>
    <name>F9W3Z4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28140"/>
    <dbReference type="OrthoDB" id="1701362at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="248" mass="26289" checksum="B96AECEB39A87A24" modified="2011-10-19" version="1">MLKLGVGIGMMGWVMVMVVVAGGTAGGTGTGSNGECQLNENAAGLPCAIAKLAEKAKNITHNHDYKDIDETWGYVAPHKEQANTGSTTLQGEIETAKRRGTLTKAEGNKLIQVALDAQNKTLEEHQKADTAFKSHNTTYQNAHHSTATALGDTRIQGNCHQTASLLSILQCHVKGTTVDSASASVSTLCEGKNHYQDPSVSTLLKLPQNFKKQDVVQRHRGRTQSGSGEVEHYGQENAANGSGGPPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W419</accession>
    <name>F9W419_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_18030</name>
        <name evidence="1" type="ORF">TCIL3000_0_28400</name>
        <name evidence="2" type="ORF">TCIL3000_0_55790</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000504">
        <property type="protein sequence ID" value="CCD11902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001738">
        <property type="protein sequence ID" value="CCD15013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002494">
        <property type="protein sequence ID" value="CCD16920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="909507at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16279" checksum="999E5B3B100C455F" modified="2011-10-19" version="1">MEECGAMVGEQQQMVKRYEFIGVLFDHDTQTVSLSEKMIRRVGESPPLEEATIEQMECVVSRLICAAGVREESLFPCYFFLKMVRRRLSRLNRGLARPSDPAALPGQALILANMWMNRLLKNRPVTPPQNLPTTAALVTDASIQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4D5</accession>
    <name>F9W4D5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_29460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000545">
        <property type="protein sequence ID" value="CCD12026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29460"/>
    <dbReference type="OrthoDB" id="1686152at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="74"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="38576" checksum="2599FCBE12339E1C" modified="2011-10-19" version="1">MTMIMKILKVMKEVVVVMVMMLIGVQAHETKLLKKDDFAMLCDVVKATTSLWDTVDSLDDLSDTKVGNTLGVIINEIFFGEKWSNGDSGYWALPEKFEGSNPVRSEVCSSDSVHNLIPSASESLAWTFLCLCTPKSTGENNLCGFRVENGGTWSEQNSRENVRELFLGVWGEHNISGVMKNCVDIDIGSNLENAKKNSKKNSQNSKPHNNRNSIVVRNDVTCKETYACVKVKKNPTWLEKLKKIKTLNLTRLQKRPKSIPPPVPASSQPIAETESPHKQAPASSQIQKELPHKNTPKAPLLTLQQEPEKKPEGIPPKPEEDPPVPKSETGGSLITLHNWPLWASLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J7</accession>
    <name>F9W4J7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000564">
        <property type="protein sequence ID" value="CCD12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30060"/>
    <dbReference type="OMA" id="GIHGQEM"/>
    <dbReference type="OrthoDB" id="1501448at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="25068" checksum="0C633A3842684C59" modified="2011-10-19" version="1">MDGPAHDGLEYLGDEVVVIGLSGKKYRRSVCVFIMNENGEFLICRRRDNRQALQCVQGGAKFGETPQQTAAREVKEEIGIPTRYLTFVSEITWPESEIATSGDGSEPRAMFRYPSKSWRKIGISGQELYPLLYCANSSIVDLVNFRSVPSVRPEFCEAFWGPLHILSQYAPKSKIDAMTNACAAVEAYVSLHSPSVAFNANAIGSKAPRRVRRRRRKSQSTGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4L0</accession>
    <name>F9W4L0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_30190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000569">
        <property type="protein sequence ID" value="CCD12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30190"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="37834" checksum="3A62917EABF0D68B" modified="2011-10-19" version="1">MSWKEISGGTKKMSNTKNELAPPGEEAAEWRKLAHGWEAQARRLARLKCHHEDQAVDLGLVMESCAEFLELVTEVIKKACDLKGKDGKKNVEKLERALTKWPEYLETETNYWEKRLRVQKGGTEADAMKEELKEQEKQADELEEELETIEEKIKKDIVPMQQSDPRLGVCPYCDRIYASAKWLKRHVREDHPGQPTTGIDEDRVSFECPHGCGKTYQTRGWLMRHLQDKHGERPQSDEAADSNPIYCPHCDKKYASVGWLNRHVQKDHEGETDPDIDACGMRVPCPFCDRKYASFVSLKKRLKDKHENEAITGSDEDSVRLSCPHCKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5F1</accession>
    <name>F9W5F1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32830</name>
        <name evidence="1" type="ORF">TCIL3000_4_500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575317">
        <property type="protein sequence ID" value="CCC89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000708">
        <property type="protein sequence ID" value="CCD12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_4_500"/>
    <dbReference type="OMA" id="RFFWVGC"/>
    <dbReference type="OrthoDB" id="1178912at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="25272" checksum="12723CE8E3077D17" modified="2011-10-19" version="1">MQSSVDIAGLLVQYFRGSAEERSVITATHPSVFTEGVVEELDNAFALLMEAHHQAREACRVIDDITDEHELPRALRMTPKELNELDVKEEVMIKRFAEKVAVYLSLGDVPNCGDCDEVLPQQTSTATAPPWHKEASLVLNVLSFLSLKFILRVAEDVCRDWREWLFCPEVSKDFWHTSVLREYQECIDLLSLSAGEGICNGDWRTLAMVCCADDDDDESCDETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J4</accession>
    <name>F9W5J4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000719">
        <property type="protein sequence ID" value="CCD12446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33250"/>
    <dbReference type="OMA" id="HRSGWDS"/>
    <dbReference type="OrthoDB" id="871749at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="956" mass="107218" checksum="10B5DAB934631456" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L6</accession>
    <name>F9W5L6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000728">
        <property type="protein sequence ID" value="CCD12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="WWSALEL"/>
    <dbReference type="OrthoDB" id="1220616at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="643" mass="70025" checksum="D75F88AB5138B0C4" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5N8</accession>
    <name>F9W5N8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000742">
        <property type="protein sequence ID" value="CCD12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33660"/>
    <dbReference type="OMA" id="ICSASRM"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394561" evidence="1">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="48112" checksum="A0617E6EB184325B" modified="2011-10-19" version="1">MCDRYIFLVVVVTLVGVVMVEARDLPALKLESAQGACAVSRLMKSMYNFVSSRNKEAQEMYESVERMYDLGRVRIAQHVLENGECDRMTFFVLFSQRIKENMTRKIRELASAGVKLVGAAGLAAGRLDEFINIFRHSWHVQTSHIFSTTYNHTYSFCLRGKGTKPVDKKSIVDCFMNDKETDDNGFVPVDGGDVHWLDQDDMGSLLDMRLKLVDGDPRDEHGQNRRCVLLSMGDGGNYLGEGNKGKKVLWADGLLGVTSGNKKKSGFTGSVRSSSYSTNIIWEAKPSSSIPVLKDFVARYNDYRKLFDEVKHLSAAMTDDWTVDHLMKYAEGIASLLYKPEELDVLLSVDENEGNETAEEDQRRLRLRHTVEPFVGLNDRKQEWLAQYNKELVSKEFLAAEIQLCRSAAELHLRRNRWFFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R1</accession>
    <name>F9W5R1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_33860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000752">
        <property type="protein sequence ID" value="CCD12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33860"/>
    <dbReference type="OMA" id="ARTDEHI"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388703" evidence="2">
        <location>
            <begin position="29"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="772" mass="85487" checksum="2F34DA8A8EF6AA55" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Y9</accession>
    <name>F9W5Y9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000801">
        <property type="protein sequence ID" value="CCD12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ACNTERA"/>
    <dbReference type="OrthoDB" id="649708at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="PTHR11937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="15785" checksum="F19143CDFC8A782C" modified="2011-10-19" version="1">MACNTERAPVVILDGGSHHLRAGYAADGAPRLDIPALVGHPRNRGVAVAAGMNEYEIGDVALAKRGMLTVSNPIERGRVVSWENMEKLWGHVMYSELPVRPESHCFIVPQPGNTEAAQREKRWSYDGNISCSLPLLGASQGLNLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W608</accession>
    <name>F9W608_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000807">
        <property type="protein sequence ID" value="CCD12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1710753at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16614" checksum="5680A72F884969E1" modified="2011-10-19" version="1">MVRGSHISLAGLKLTHIIEHSARLSKAFPFTTSGTFSGSHTHTYTAIGMPHAHQWMRPQGLTHLLPGDTIGSQHITYHSHLRDSSGHIKHMSDTMWSRTHNQVPHSSLVTEHPGLKYLISTSLCPTRQIHRVPTQHGTATRKSNGKRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W676</accession>
    <name>F9W676_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1431</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000831">
        <property type="protein sequence ID" value="CCD12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35400"/>
    <dbReference type="OrthoDB" id="1357527at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="SSF47576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="596" mass="63701" checksum="714BCC42A8897F71" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W690</accession>
    <name>F9W690_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000837">
        <property type="protein sequence ID" value="CCD12695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13284" checksum="773080EE4B966AEC" modified="2011-10-19" version="1">MAHSTKNALPRHCQRPGSPRWCAAVIQKKVAPDSDKDSYYTLLACHMKRDHPGHRESLRPESCLKVKTYKASQGTVGESDRWRVCRKDDRKAVTDDGPVKCKGLQGNENCVNRDFVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6K0</accession>
    <name>F9W6K0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000887">
        <property type="protein sequence ID" value="CCD12807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11624" checksum="010477DA5C46BE4D" modified="2011-10-19" version="1">MILEKIQKRMCFQGLSYEEFNSSAPVSMVTTLETRIYSIPLTIWWSQKQPPLMGSMWSLSQSFMFTIVPSISKLCYSESDIPLERSIQEKKQNKTEPHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6K4</accession>
    <name>F9W6K4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_36590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000889">
        <property type="protein sequence ID" value="CCD12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36590"/>
    <dbReference type="OMA" id="DEYVKCN"/>
    <dbReference type="OrthoDB" id="1117527at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="SSF100966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="5">
        <location>
            <begin position="180"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="318" mass="35458" checksum="D216845783DD0191" modified="2011-10-19" version="1">MAEKQEGVGGVQRRERARGGPTSRKENKEEATHPAGPRPKAPRAAEVVLDAPEVSHKDPLMLPTTHALNDTAAMERAAAEDIFTIPYDSYTAADLHALLQRVTRKDVERRMVEREQQRRKENQAPRVERFLDAAVGADRTGSSSTNTGASSEVCCGYAYDDMLQRLVIALNRNKESGGMSERNKLPVPMVEKVGKKKVAIINFGKICEAFNRPIEDVKDYIEKELSVGGNLDSSEALILKYEIQKVTAFDKILIKYLDEYVKCNSCHKIDTTLAKEGRRMELRCNWCTATRSVQAVGSATYSAQVGKRSRARRQAMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6L0</accession>
    <name>F9W6L0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000891">
        <property type="protein sequence ID" value="CCD12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36650"/>
    <dbReference type="OrthoDB" id="1713184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19675" checksum="C1263C893B5402B8" modified="2011-10-19" version="1">MVMHVSYLPWECEAERSRASVLSRYRLPASIYSFEAADQQCRLEEKWLYKPGWKNFPIACGFFLVDAVSEGVSLSEGAEAPTQAMVLLKVTKTRYHHTKTSKVKRFLNRMAETFTNWDEMESRLRCEIIYLLHADSATIKTRQRCDSGGMACDAGIEEFCDGIGQLLVKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N8</accession>
    <name>F9W6N8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_36860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000900">
        <property type="protein sequence ID" value="CCD12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36860"/>
    <dbReference type="OrthoDB" id="1570520at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="PTHR22937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="49435" checksum="9C1F2D0C2B00A025" modified="2011-10-19" version="1" fragment="single">MARWDNQVLETPFTYSTLGTRGSCEYPFQPSTAPSTYAPNPAGAPHQLQSSMVQLLVSDPRRNGATVLNSISPGVQISGQNLSRGGHVMFQGHVPQGDVRTHIMHHTDPHARSCHSTNNIPLPHQIPVTFGAQYDPAGPMHSFADDPSRIMWQTTMMYTPQPWAPMDGPSRAALRHQPPWIVVEQEPLAAAHRCLVVDAERQLASRQRMCSRWWSQHPRDVNHLQHQPNHRSHAYQQHTGRTGPFNAPARQFSRRNHFAFNRWKQNGVPVDGQFNFSSLLAPEAATRPPTPSPGNRLRHVRSWRGDNVGSQRELRLHNMYTFEAAMNLDVDNMSYEQLLELAERVGRVERGVDPDRLKELCVRVTPENAERGSANPSLIDVGSALPTTNGERERHVSCQADAKMEDSLMCCICLDDLNVGHLATRMPCCGNFFHCTVRGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Q9</accession>
    <name>F9W6Q9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 150</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000917">
        <property type="protein sequence ID" value="CCD12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03690"/>
    <dbReference type="OrthoDB" id="1726041at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17901" checksum="3F44B2789682BF7A" modified="2011-10-19" version="1">MATITKNKTFIILSPESPNYISYSSLVSKQRKKYERDITMDKHHFQINAHPSQNITQQSHILLNQTPHNNIEELTFIIIVIVNLRIVPREQYSVGRVLFMSYRACFNNRVSMIIHHSIMRTILHGQLLRHTLFIIPIRMPFPNSCLSVLTHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6S0</accession>
    <name>F9W6S0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000923">
        <property type="protein sequence ID" value="CCD12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37160"/>
    <dbReference type="OMA" id="GANPAMD"/>
    <dbReference type="OrthoDB" id="861498at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="483" mass="52093" checksum="E0543E63051D62C7" modified="2011-10-19" version="1">MQAGYGGRGRGMSRGRGGAGGFDNPKGLMRQPFIPSTTPTDTLCVRITEIRQPVTEDMMYRVFASISTNPRRLQISPSSDPNETLVMAQFSDSYATQRVMESLNNRNIFNDGNKMMISYSSWEPSPVLPAPTSVGSVYGAPGQVYGGVQVVPNVGFPQAQGQPGAYPQVRQPQVQQMPQMPMQVMMPQMRVGNDQHGGRGGRGRGRGGARGAGGVAAPGPMMGFDPMMMGYPAMAPMMQMPNGMMAAYANQKNVAQNTPTVFLSVTIVPETEPLYSIFVLIEVFGGVVTIRRNHNKKEILTVKMASVPEADNVVQYLRKVPFAGGTVSAKRFPTYNERTPCTDDGNPHDSATIQYDFTTARHRSPGQRSKCQPSTVLKVTGCGGYSEADVMTYFTSENFYPDRIIKDDEGAFTVHMADRETAVALLLKCHNNVCGEERSNVLFIEGPKEAASATNAASGSTNTQAGATTCDNEVEGGETNAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T1</accession>
    <name>F9W6T1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1522</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000932">
        <property type="protein sequence ID" value="CCD12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37260"/>
    <dbReference type="OMA" id="PHLMMAF"/>
    <dbReference type="OrthoDB" id="904224at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="43032" checksum="B772663863AA7B45" modified="2011-10-19" version="1">MKRQLLPFAARQHYLEHGYAILPNVLSPPLVGQLRESLIASTVARSRYFIDLPDMDSLLKSREKLSDPLYTKVMERLQRRKHIMRQYREEKRQRKRLAKVAANILNGRKKEDLSGEELWRLSEALAKEVGKMSGKGCEATVSNDPQMLRAINQYRCNVWMTNKDLQAMVRDPSFTETIGEVATNVGGVERPVLFCDAPMFREPYGGPFGYHCTAPTIGVKTNGKSTNAVSLLVFTHRPDKQTMPMFVLKGSHLFVREQYISRVLPSDLALSFLPMETHIPEQLKRFDFDDSVIGAPIDDGDMIAPGTVVVVDPHLMIGLGTNASPSRVVVYKMNIVAEDASPMMRAPSWITGWRSLRREVSFSSPVVFPPLYNPAQIRGNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6V1</accession>
    <name>F9W6V1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1529</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000940">
        <property type="protein sequence ID" value="CCD12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37420"/>
    <dbReference type="OrthoDB" id="1681549at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="261" mass="29577" checksum="FEF4923B0084A724" modified="2011-10-19" version="1" fragment="single">MTSNNHVGRHPGDQARNNYFRQYTENDSCIMDFQKAHPNYTSHFPHANIFSDENEVTNTFALTGRHGPQNAWSPPPRKPVQVEDRSFSVTAERDRNSGLRDAQKDFFHGANVPSNETREPGMNFRTIGREMDHTVVPGYLSNDGEEQLRIPSPETKGEHEKIPIVPRTFGTRYPPGTSCHVMTLRKRSRSHESPGGYLATFKSTAKTKGYQGLQRLPAPRVEYMGEVIDGLTRLLLPRMTCEVKPSDEGVHESYPLAIARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6W2</accession>
    <name>F9W6W2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_03810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000942">
        <property type="protein sequence ID" value="CCD12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03810"/>
    <dbReference type="OMA" id="CTRCVWD"/>
    <dbReference type="OrthoDB" id="381953at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_1" evidence="1">
        <location>
            <begin position="449"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="67516" checksum="5AA20C780F252ECF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W714</accession>
    <name>F9W714_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_37910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000961">
        <property type="protein sequence ID" value="CCD12972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37910"/>
    <dbReference type="OMA" id="GRLICHG"/>
    <dbReference type="OrthoDB" id="330961at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="PTHR32019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-assoc" evidence="2">
        <location>
            <begin position="179"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="464" mass="52432" checksum="532326672408CF2B" modified="2011-10-19" version="1">MSVSTEEATVEPLTISHGSSKNDAEESSTQVSDATTLRTTAVPLSMPRHAKKQRYNRLIEVTDSSADCMTVADVLQHTKETLTVYNGPAVYEEEMNFHPYELYKHGKRKIHTGSVGYSSGTDLVMIREAVSETSDGDLQFFHRRSTIGSVLCLDPAAQRPLTKEEEEKQAESEAKDGKKKPLKGEAYRKYPGVRHPRNRKVRNRLLNSHFATPFGREIMAKYRERQEKGEADADMTPPLRPIFSDLPAIFYSIMDLDEDAQTAALERYGVRMNRTPTAPARDPDSGEVRFQNLNSRLRGELVHALDSEFLTQQIEDLERSFASFINNGDVGKSLTYRFRDGYGRLVCHGVAAYYQLVSQSHQRPDGTKTTVVSWPKRHKKKKSAATLNLPKVTLMSLLRKKRNEMPCVSTPPDVDTPLLNSEKSMDRPETLVLPPALENYREIDSISDSFDVDELMPVYQPFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W738</accession>
    <name>F9W738_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1559</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000973">
        <property type="protein sequence ID" value="CCD12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38150"/>
    <dbReference type="OrthoDB" id="1654994at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="746" mass="84387" checksum="027423ED364F098A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W762</accession>
    <name>F9W762_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="16050" checksum="DF7F2ABC516E16EF" modified="2011-10-19" version="1">MHKTMKMAVTTQMQKKWIFFFFFFLKGKKGTENKDTCRYNHKTDRKEHPLQQLQVQKDAHNQALVSCNTHAVRILVVIARPSIPLLSLLLRQTGSLRQRKRREAADTPPLPDHVCTRALRDNKTNQFLNFLLILLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7A5</accession>
    <name>F9W7A5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_03950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03950"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389888" evidence="5">
        <location>
            <begin position="30"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="41062" checksum="B13DEE9914F1D29C" modified="2011-10-19" version="1">MTVLLGIRMKALVLGMVVVLSVVMSLGSGHNEDAFKVLCDVLRSTERLLSTNTISEPSKSVLEEALYGKSGRILTVKNGMVSVNRNSICQTNRGLLCTFYGGGARNYGCFAESLAGTLLCTCTPGQSGGSKGFCGLENFQNADAWTVGGRTPLEQKENLFQKVWDNVIKKCSHGNGNVHSTEDKVGDLETAVQKVRGTLKQGPRGKNNFFYLGEPVGCNGCSGSNPRDVCAAYHTGRTNDKHTVHIPWANTIENALSDLKKALKPKAPETVSVPATLAASATTTTETQTIFPTKPSDPSTTTNTTEQGNTEDGHHTETEAPAHQSSPKSRSKRSTAESPTATSTATEDTSTIGEPEILDPTAAPFPLADGADILTPLGLFMAASSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S4</accession>
    <name>F9W7S4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1648</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001073">
        <property type="protein sequence ID" value="CCD13246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40150"/>
    <dbReference type="OrthoDB" id="1725600at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17502" checksum="2CD4565351168F63" modified="2011-10-19" version="1">MRPWGLGKKLLTGAPQWRCASLTSHGSGFAAATTWWSKRSSKKMRSAYSVKTSREGVPLLLIFSNFFSMSVCKDFPYSFSFLGVIVFRVPFTKTAPPQDRTGTLDLWSKCPPRPRCFPHRLSPDARASLKSEAWLARTKVARVESAKWLLLWVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W0</accession>
    <name>F9W7W0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001087">
        <property type="protein sequence ID" value="CCD13282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40510"/>
    <dbReference type="OrthoDB" id="616687at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="30441" checksum="799EC1C08F6D43FD" modified="2011-10-19" version="1">MGYVTTRDGVEIFYKDWGPRDAQVIFFHHGWPLSADDWDAQMLFFLGKGYRVVAHDRRGHGRSSQVWDGHDMDHYADDVAAVVEHLGVQTAVHVGHSTGGGEVVHYIARHGEDRVSKAAIISAVPPLMVQTPSNPGGLPKSVFDDLQAQLKANRAQFYQDVPAGPFYGYNRPGAKPSEGIILNWWRQGMMGCAKAHYDGIVAFSQTDFTEDLKSIQIPVLVMHGDDDQIVPHENAGVLSAKLLKNSTLKIYPGFPHGMPTTHADTINADLLAFIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W819</accession>
    <name>F9W819_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_04440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001121">
        <property type="protein sequence ID" value="CCD13345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04440"/>
    <dbReference type="OMA" id="QSRICMF"/>
    <dbReference type="OrthoDB" id="823277at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="PTHR30073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00669">
        <property type="entry name" value="asnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="4">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="39642" checksum="C63FDD5524CB4926" modified="2011-10-19" version="1">MSGDEFSHYLLLQGQIRTVKKVFSEALERKLRLVEVQSPILFRTGDGTQDNLSGFEKAVKVSVKAIPDASFEVVHSLAKWKRQVLASYGFPVGSGLYTHMTALRVEDVLDNVHSVVVDQWDWEMVIEEKQRNLPFLKDVVGKLYAAVRETEFVVCKMYEQKPVLPETIHFVHAEQLLQAYPTLSPKEREREIVKKYGAVFLVGIGGQLSCGERHDARAPDYDDWSSPVEGSEMASPGTGELTPTMNSLCSLKGLNGDILLYNPVLDDVLELSSMGIRVDADTLRRQLELTGDEELMKSEWHQKLLNGEFPQTVGGGIGQSRLIMFMLRKEHIGQVQCSVWREETRREYGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W822</accession>
    <name>F9W822_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein TCIL3000_11_6840</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41060</name>
        <name evidence="6" type="ORF">TCIL3000_11_6840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001123">
        <property type="protein sequence ID" value="CCD13348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.6840"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41060"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="1532160at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="5">
        <location>
            <begin position="64"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC95258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23231" checksum="1D46615889BAAD69" modified="2011-10-19" version="1">MHPNVHSRFIIKREGVMSVKAPKLFNKWSYDNLQTAEIALSDYITRTPTYVPHSAGRWQKKRFRKARIPIVERLTNGLMFKGRGNGKKLQAVRLVRHTLDIIHLLTDQNPIQVVIDAVSKGAPREDSTRVGAGGVVRRQAVDVSPMRRVNEAIYLMCKGAREAAFRNLKTLPECLADEIVNASKGSSNSYAIKKKDEVERVAKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W828</accession>
    <name>F9W828_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001125">
        <property type="protein sequence ID" value="CCD13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1843293at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17278" checksum="4D6BF18555153ECE" modified="2011-10-19" version="1">MTQQRTYSGMRVAPLSIDYPVSHHTTQESTYTIDKLASIGPRRVAARFSPCLRKYRWDPYAVLLTDYDLERVKKSYRRATGPTVVLQQKPYGQHNSAAENADCHNHTNNHQHNHRHRQQQPPSGPLRYQHHQWPRAAAPQGYGVRSLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D8</accession>
    <name>F9W8D8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42190"/>
    <dbReference type="OrthoDB" id="1663680at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="516" mass="54677" checksum="D94AB0E36393BEDE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8E6</accession>
    <name>F9W8E6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001165">
        <property type="protein sequence ID" value="CCD13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42270"/>
    <dbReference type="OrthoDB" id="1714264at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18789" checksum="0E73457EC199E918" modified="2011-10-19" version="1">MALVFRDWAVRRTGKLEKECIAVSSAFRGWKGHHFPLLHRKMRSLGLLSTNVTFNLWGKLDRIPVPLHADHNRTRRDTPVKTIDLAEHLHGDNMVLCIFNKAHSRTVKTEQNFVARCQRVSVARFAKVGTPTPMRNGIDVAQGLGASGAVEGESVVLLLEQSLCAALIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F4</accession>
    <name>F9W8F4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001166">
        <property type="protein sequence ID" value="CCD13486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04490"/>
    <dbReference type="OMA" id="KVFGYFA"/>
    <dbReference type="OrthoDB" id="230775at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="PTHR22781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Adaptin_N" evidence="6">
        <location>
            <begin position="33"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="797"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="835" mass="93344" checksum="5BFF5771745A9FF1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8T2</accession>
    <name>F9W8T2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1774</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001213">
        <property type="protein sequence ID" value="CCD13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43560"/>
    <dbReference type="OrthoDB" id="1706674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19413" checksum="F043F6228A031126" modified="2011-10-19" version="1">MISGGEWRDTCCSISHALNPSLKLGVPIIKLSSTLSARLMRFLGKYETLCTPLNPPACCFGRPFRQSSGHKKINDSGDFLRHNSITSSLLEHCLRPRATAQIPKRHPNVGPRGACVAPWSKYRTSKQWPAGSSDGAYLSGCPKQAQPSTKQLCTVMLDRNTPKRAATISVDRLHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W901</accession>
    <name>F9W901_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001248">
        <property type="protein sequence ID" value="CCD13690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44240"/>
    <dbReference type="OrthoDB" id="1737020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="16973" checksum="03F58CCD3F56E985" modified="2011-10-19" version="1" fragment="single">MFPPSGDSEAINSMCEETPTAVGATDVPGQADPRQPRALQRTEAVTDEPNNYLRQEALGANNNNSSSTTARKFPTHLHINVTPQLGGEEIGGNPLRECRTPFSTMQSVPSPAVESSTFLSTAHSFGSSCASSPATSSAMHPSHTTMIGSSPFMSVRGPAISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W959</accession>
    <name>F9W959_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_44560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001269">
        <property type="protein sequence ID" value="CCD13749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44560"/>
    <dbReference type="OrthoDB" id="1717934at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032694">
        <property type="entry name" value="CopC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008457">
        <property type="entry name" value="Cu-R_CopD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34820">
        <property type="entry name" value="PTHR34820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05425">
        <property type="entry name" value="CopD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="CopD" evidence="7">
        <location>
            <begin position="96"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="23220" checksum="2D370598DB06411B" modified="2011-10-19" version="1">MVRIGALVTAIIGVSLNKRFPTLSLWIVTVCGAIALATLAWTGHGAMDEGSRRYWHFTSDIFHLLAAGGWLGALAAFALLLRLKSLKGDQEARILARVLTGFESAGAVIVVIISITGVANYLFIVGPNLDEVMLSTYGELLFLKVLLFAGMIVLATLNRFHLSPLLERSVRNGDYAVAVNALRRSMKLEFSMAVIIVCLVAWLGTLSPVMEMSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9W6</accession>
    <name>F9W9W6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001359">
        <property type="protein sequence ID" value="CCD14021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="14709" checksum="64172E7654355EAD" modified="2011-10-19" version="1">MYKGDERGHNVNLCNTVWHFSTVPFPFRTTLLLFFFSKRKLMYISDILRTLRLSADITLYLSFLSLCPFSFWFLLHSAFFPLYILFLIILFICVYFFSLITHKKKERRERDPLSSRLVGHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA84</accession>
    <name>F9WA84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30420</name>
        <name evidence="2" type="ORF">TCIL3000_0_48000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000580">
        <property type="protein sequence ID" value="CCD12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001406">
        <property type="protein sequence ID" value="CCD14140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="631249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16542" checksum="293A0421FE04D14D" modified="2011-10-19" version="1">MIMDFKISLFLPSLSQCSQLTEVSFVKNFLPTCSLKNLLKYTSNMRQLTLGKYPTHHEDIDDILLYRFVQLCSELMDTLKVIRQPKEVCFGLEGEMAQWLRALTALQGVLSSNPSNHIVSYNHDEIFCPLCLKSASVNLCIIHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC7</accession>
    <name>F9WAC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001414">
        <property type="protein sequence ID" value="CCD14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48360"/>
    <dbReference type="OMA" id="CARHISW"/>
    <dbReference type="OrthoDB" id="1667028at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388898" evidence="5">
        <location>
            <begin position="19"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="43893" checksum="F31C18BE3DF0CB52" modified="2011-10-19" version="1">MMKLFMVMMVVMGSLVREWRVMANAKDSVAQGDNSEYFSLLCRIYNVAQHPPIKHVDTKEYQKIVDDIDALSASANGKEGVKTQSEETKSAQTQLVGITRDAHKLLDEIKRINPEREAEMARNALNQVIFGEHGKEGDLSPGTLNGVRGRMAACGSRPLDKKGESAGKNLVVDFFCLCAKHDEAEGVDNVCGVSVGNGKDSGWDGVKLVSQDTLWDEVKNGCGTFAKQGVTSTQDGYSLHREFMAKVKAGGKVKVTNTETVPKHGMLGTAVSDTGNSNFHCNGKKAVSTTRVNVGSGVCVFYGTHHQEQNIEWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKTDSQQEEVDTDDSPLAQHPNPDENENADSATQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX7</accession>
    <name>F9WAX7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2029</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001496">
        <property type="protein sequence ID" value="CCD14401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50180"/>
    <dbReference type="OMA" id="HCTEERD"/>
    <dbReference type="OrthoDB" id="1323965at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="16227" checksum="2D4F74BD67272B4C" modified="2011-10-19" version="1">MFFTVDGLLVERCDGGASGDILGVSDGRQLIVLHRLLHRLHSSKGDLEEDGRKPFVGGGAFLDPPCGSVGVTAIGENTNLVANDGMVGLARWDDGSDMSGGVALVLSTSERTLSCAQRKVPDTGDTLFWCTATAKDGCGMRDLSVGAGNADTVGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAY3</accession>
    <name>F9WAY3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_05390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001499">
        <property type="protein sequence ID" value="CCD14409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05390"/>
    <dbReference type="OMA" id="IPRAMES"/>
    <dbReference type="OrthoDB" id="1152279at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
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    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="9"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
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            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="38914" checksum="12498117DA159627" modified="2011-10-19" version="1">MESIVRKPRVRALMRFRPLSEDERELQRREGTPEPWLMYDGSVVRVKEIRNSLKRVHGGGFSEGDVASPERDVPSTALLHAPVVNYSFDAIFSDMSTQQDVYDIIGVSTVENVLKGYNSTIFSYGMTGSGKTHTMYGPSGALDDMFLEDSPHYSNRGLVPRIVEELFKCIGATNAAEGTWQVQVQMFEIYKDSIVDLLHNSHRPQPEHRIREDNNENGRGIYVDALEAVKCESAEELLSVLQCGTASRHTRETGVNDRSSRSHCLLCIFVKQRRSSDPPYSIESRLNLVDLAGSERIAQTGAEGESLKEAQHINLSLALLGNVIQRQTNAAPGNTEKLRSMSRDEASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ0</accession>
    <name>F9WAZ0_TRYCI</name>
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        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2037</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001505">
        <property type="protein sequence ID" value="CCD14416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="AFYVYET"/>
    <dbReference type="OrthoDB" id="285696at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="575" mass="63464" checksum="12BDF94A384C0F95" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB10</accession>
    <name>F9WB10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2045</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001514">
        <property type="protein sequence ID" value="CCD14437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50520"/>
    <dbReference type="OrthoDB" id="8207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1196" mass="133220" checksum="0EB99360A0A64BEC" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB39</accession>
    <name>F9WB39_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001527">
        <property type="protein sequence ID" value="CCD14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50800"/>
    <dbReference type="OMA" id="GADCSYC"/>
    <dbReference type="OrthoDB" id="1654357at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1085" mass="114802" checksum="4A72FCADCE6215F3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC7</accession>
    <name>F9WBC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_51650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001563">
        <property type="protein sequence ID" value="CCD14558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51650"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388937" evidence="6">
        <location>
            <begin position="24"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="96"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="47019" checksum="1E579B797E00D36A" modified="2011-10-19" version="1">MVCFVNLILVSAMICNFVTDATAQGAQVQNNDNSEQFALLCRIYNAAKNPPIDHVNLHDPLNIVKEIDALNASLAEEKQFNETENVENSSDAQLSHTTTREAAVAQAILKSITKRAHKILEVIKKVNVTEELENVKAEFDKVIFGDGGNEDDLCQGAFKNVGQRAEACGKPGAGIKGNHAGKNLVVDSFCLCAQLADGNGIDNVCGMYVGSKNGKNGWDTTCPSTSSTMWAAIKKECGKLLHQHPKSTEEAYEVLEDFLKHLKAGGLYRWGTTDNNGVKGSDRKGGMLGTAAGTKESNQEEGLVCDGSKGNKSPNHAKARSRSGTLLPGGVCVYYGTDSEWQNIPWMMKLKTALSTVDALNNKTATIQRDIDRLEQLLHRAEEIYETAKVITEIQKPVIPTNLQTAAKRLTAYNAARGHHTHTHFILLFVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBG9</accession>
    <name>F9WBG9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52060"/>
    <dbReference type="OrthoDB" id="1711833at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20172" checksum="A64185B3DBB11AA6" modified="2011-10-19" version="1">MKENIIAAQLHFHCLDTCKGHSHHTPRNVVRPLHSHIGSHTLHCNTPQLISFLPSLSRMVPHLPRSIGRGGCYDPFKASHSHASPITTKEKWLQDLLSQPHIHWALSPHLPFEHLQRPHASATPSRTRRCSRGRGGKYIWGACLYSTELQNELGNARHYLSGVIALTTRFQFPPWSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH8</accession>
    <name>F9WBH8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52150"/>
    <dbReference type="OMA" id="TIVIQHF"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="478" mass="54345" checksum="DFF44745ACCDADEC" modified="2011-10-19" version="1">MKERAYIFHREDRRVVFYKKEEVAVDEIEEMVSKGVEGYIIYDMGGGHNSIHSLPDEWGAVLLTSPKSSNYERWSADRLGETLPIYVDCYEYAEFKAVLIWERKKLGSDRLRLRKRPSTILEDWEVLRNRIYKVGPVPRYVLRSDGVFNARVRVMCGAVKTLNYDDLGNFMRKLRNEKEWPGDNTTHKIVMLVRTLGDEGDACRNQTVSSHIRTQLNTIVIQHFCNTRVSYSALCTAAEHGAHALEEAGILAFLIRSVSDVMVRHLKHLPREGETEESRTSVLARVSAWGRVPSRRGGFDDGDQYLSLQPDKLYSSTSVNFPVVDGFFLVDAVGEGVSFTEGAAAPTQTIVLIQVTRARDHHTTTSKVEAFRKRMARSFTNWKEMERRLSYEIIYVQHADSTTLTGRQRCARSGVANDAGNERFWSGIHQFCVKLDAPIAKLLFEDIYGAELIEEAGAPVATETRIKRRRVEDVAATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBK3</accession>
    <name>F9WBK3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001591">
        <property type="protein sequence ID" value="CCD14636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52360"/>
    <dbReference type="OrthoDB" id="1715848at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16742" checksum="A0E25EE3C69D287A" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTPAQCRGHKPQCGQQLLHAFSLHHVPRVLGCTWCRPAVIKSAHGNTRGNCTSAFHFIPSSGSTASQQSPHCLEAHRNEERCDTSYHTHVTAPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBL8</accession>
    <name>F9WBL8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2120</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_52500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
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                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
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    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="192"/>
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        <location>
            <begin position="339"/>
            <end position="399"/>
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            <begin position="499"/>
            <end position="543"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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    </evidence>
    <sequence length="551" mass="61244" checksum="134F2C0206C154DB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
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                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
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                <person name="McQuillan J."/>
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                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
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            <begin position="41"/>
            <end position="59"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="CCD14789.1"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC39</accession>
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                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
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                <person name="Harris D."/>
                <person name="Hauser H."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
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                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
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                <person name="Gilderthorp R."/>
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                <person name="McQuillan J."/>
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                <person name="Field M.C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
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        </source>
    </evidence>
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        <source>
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    <sequence length="190" mass="21268" checksum="BB8358E69D269D7E" modified="2011-10-19" version="1">MCEMRGAALLYLKFCLCALYRLPTLPEPFEDSALHEDLHLPRRHAALLSSFLLPCAFRGATAAPTNGSLLCNSDQGALYYCWQAESGTLCWSAIRSILIRGSSSQVLIALGVHNSSRKQRLFLPSSICGACFTFWIIVRRCFDTTDINYRELLMQGIEISNSRDLRGALHVTGMLSRKEHCHAVNRSSKR</sequence>
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<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
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            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
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                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
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                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CFAP46"/>
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            <begin position="556"/>
            <end position="575"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1078" mass="120680" checksum="45F8EEFF28E0F498" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE5</accession>
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            <taxon>Nannomonas</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001707">
        <property type="protein sequence ID" value="CCD14938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55060"/>
    <dbReference type="OMA" id="FMRQTWA"/>
    <dbReference type="OrthoDB" id="1173903at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="263" mass="29446" checksum="3695FFBAB7BD7F21" modified="2011-10-19" version="1">MTCIVQAPPPAAIQDHCVKLCKMEAGYVLPTASGSLKAPAVPRVPRRNTFTVSYAYCRPDANIGKAFLDEHAPPPRHDMEFQRATLRHHHLGKTRELVEQCEKESIRSRTEHGIIALKLLVRTAAERSVRLACACGSESSVVYFVRRVWSSLLHQMEAFFSDALGGSPTQRMRVATEYVSAMGIWFDGDMSLSFRRHVVQMPLADGTTQDVLVVGLAFFGYSSYVTDLRRRSQLEVLSELRRLSKQLGQKVLFSPVPWNGPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCF6</accession>
    <name>F9WCF6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_55170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01001715">
        <property type="protein sequence ID" value="CCD14949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55170"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="519426at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="8">
        <location>
            <begin position="3"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="9">
        <location>
            <begin position="270"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="512" mass="56191" checksum="497C93C36AF93E08" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCM5</accession>
    <name>F9WCM5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2247</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_55850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001739">
        <property type="protein sequence ID" value="CCD15019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55850"/>
    <dbReference type="OrthoDB" id="1669753at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394875" evidence="4">
        <location>
            <begin position="21"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="92"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="375" mass="41645" checksum="AFC4A2C3D72381A2" modified="2011-10-19" version="1">MACFMYVIAVVVIMGGVATGQLEVAKDDNIEPFSLLCRIYSVAKNPPITDFDMEEGYNIVREIDALNRSLLEEKTHGEVEDVGNNSETQVKTTVTREAVLAQLSLNQITQKAHTILDEINKMNLTEKIEKVKAEFNKVIFGENGNESDLCQATVKDTVDRSKACGNPGTQEKGSHAGKNIVVDFFCLCAQRTDKEGANQVCGFYVGRISHYYGWDDKNGPWGSSTMWASIKGGCGKYMQQHPKSTAEARHILDQFLKHLKTGGVYRWGDISKKTVDGTGRKEGMLGTGVGKKEGGSGPVCDGKEGKSVRDGTFSAGMCVYYGPDKWQENIDWLKQFKTALATLDYVNKQTASIQRIIKNSKCSYTVRRKFMRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT7</accession>
    <name>F9WCT7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2267</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001761">
        <property type="protein sequence ID" value="CCD15085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56480"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18805" checksum="6B901B166BA95910" modified="2011-10-19" version="1" fragment="single">MRRWLALPKAQRMYQLLEPLRGLQQSLRIPSVQLAPPRSHTHEDMAYASCPACSRVVHMCDMLTHLTTAHRELNPAHCRKICADRLSLYERVIGVPLKKNQLTSSGHRVLDFLPTVLAAGYMCNWCDRRSDVYATRDKFLKHVADVHSEIDWRKWNHIPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCU1</accession>
    <name>F9WCU1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001762">
        <property type="protein sequence ID" value="CCD15089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56520"/>
    <dbReference type="OMA" id="SIGASWQ"/>
    <dbReference type="OrthoDB" id="1503302at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="31113" checksum="DB049584DEB577D8" modified="2011-10-19" version="1">MESSVASLMEHLNGVETRRRIVMMKRKEAEAKLSFVTEEQQSLEQQRSANELREAELKKELDHLLEEQRQIQLQLMTGADTIRQSEVEETLLMEHVQSQVSKSEALVEEWSTHLEALEKLQKAWETDNVAAPLVKHLEELEEESTKLHNRNEQLESSIKEAVQANNTRIAAMTTSAPVPTGSPTVQKSTEDHDVAVAQLMERLELEMRDLDELRAQNARQIAAVDREVTDLIDRSTELGQWLGDTITSRDQTLANIQLLPKCLASSFCVSCSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD18</accession>
    <name>F9WD18_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2307</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001805">
        <property type="protein sequence ID" value="CCD15166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VDFVGCV"/>
    <dbReference type="OrthoDB" id="1654793at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="845" mass="90128" checksum="4967EF9F627F22D8" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD55</accession>
    <name>F9WD55_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2322</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001823">
        <property type="protein sequence ID" value="CCD15206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57500"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="912" mass="108645" checksum="A5487D364F97D5EB" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD95</accession>
    <name>F9WD95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001840">
        <property type="protein sequence ID" value="CCD15246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57880"/>
    <dbReference type="OMA" id="NCESTAD"/>
    <dbReference type="OrthoDB" id="750722at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GTPase-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GTPase_TBC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="SSF47923"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="90"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="50558" checksum="00A1117B3F10915F" modified="2011-10-19" version="1">MFQRAKKWARLHFGLSDGRDADTTKNKVGVEGLQAHSSEIRNCESTADTVQKKSKAHHEEESVYDENFLRDILSRDPVPIDELRGVSRRGCPAGFRYEVWCYLAGYLQPSRFNRATILARKRQEYVGYMQSSYGAVDWDAAFATAENGVGIVAVGETNMGSLHTPFGHGASKASSSLNTPSESELVILKQIRKDVHRLSAGVAYLSNKRVVLSLERCLYIWALRHPACGYVQGMDDFAIPFISVVLANRVCRAKTVADLYTLDEEEVEALLSMEVIGEEEWVSTIEADTYWLVSYLLNSVQENFTYNQRGLHRMVQKLESVVRTVNLKLCNHLLDNLQINFTQFSFRWMNCFLLRELNATQALRLWDAYLADEEKDWCTTHVYTCAAFLQWWAAALLQEDDYCVAMKFLQNLPTNELSDQDISVIISQGVVMKKLYNSAVAHLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ8</accession>
    <name>F9WDJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_58790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001878">
        <property type="protein sequence ID" value="CCD15352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58790"/>
    <dbReference type="OrthoDB" id="1664294at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="112"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="409" mass="46860" checksum="6DFB80AB5B8CA244" modified="2011-10-19" version="1">MRLYIKRRGHLFSMHVGIVANILLFAAFTLPNSWASERVRNQAEFSALCWFLRISNTAEWALTTDNFKHLAPESLLKRQQLLEWLQQNGSDTLEALEDQLDVAFWYLNETERHAARRMYQAFDKRKSSISELQIKIQEKANQSRQILENISILFRAVRYGDSRKGETSEEWIDNVYTKAAQRNRTCNMKNSDPSQPRAGSSLVNDLLCLCAVGDIDGGDHNEMICGIELDPNSTWTDASGFTPYTAGQEWNRIWQGCMKLQDKADLTVENLQGAIDHFESLLGTNAREVDPENDLHEFQWVLGYAGTGWDVTPFSVCSASSYYPEDALGQCVNYANETGDERGNIAWLQTLQEILAQLRTYEDIHREVEYLEREVDNIGKDMEEEFELSGLNYQEPSKPQSLLFLLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY2</accession>
    <name>F9WDY2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001928">
        <property type="protein sequence ID" value="CCD15487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1686745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="29340" checksum="C2BA4A8606906B7B" modified="2011-10-19" version="1">MQQQLEHLQGIIAQQAAQLEEYVRTDATLRQQLTGQGVGVHTEEGERHHGKQDTGNVKRMDEYAWKGFPPHAPRPSSGGVGIRGIKELQGNSWMSGVRPEYKYSYISVSAMEYLEDRNPEQLIAAYQYMSPTAATPGPAYTEAWKNFVSWALGLRSEGISEGHLQLGRQLYNQLRTIQTVKDHPGVKIEDIRESVEYPHRKDDVFIQAALKAKRHQTAIPPGRAQCFTCGRVVHYSSSCRVFKKKPESHPTNGFRPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF2</accession>
    <name>F9WEF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002002">
        <property type="protein sequence ID" value="CCD15659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06770"/>
    <dbReference type="OMA" id="ISPIACK"/>
    <dbReference type="OrthoDB" id="1199523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="668" mass="74875" checksum="6E17F7B2FC959825" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEL2</accession>
    <name>F9WEL2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_07350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002032">
        <property type="protein sequence ID" value="CCD15723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07350"/>
    <dbReference type="OrthoDB" id="1665868at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394715" evidence="5">
        <location>
            <begin position="29"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="115"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="43986" checksum="95CD77FE8DD26329" modified="2011-10-19" version="1">MQIHPQIPNTRLVGIQLLVCASICNALASDPSSVSTAVEYRAMCRIYRIALKHHNDSASAYVGSKLDWKRFGELYKRAKACLNGTGNTTEGEVELETDFGSVKLSSGPVTVKVHELCAAFASRMRDIMKKAEGFRSNAERAARKAFSSLSGVITTENNLTNIAHKPLGLNESTNRHTVCNSHTKGGGAGVQLTVDVMCLCGPENGSTDKACGFYINGYWHGSSHEGVENIWSKIHNDCLQLPLDDDISPSNIDASVEHFDQLLGAQSGTHGEEQANSSWIIGNTMEYSGCTKGNPEKAVCVDYANADGSLGEIKWKTQINKTRDLLLKAETNIAKANELLERMELLLVVLEKELSGIGIFNEANFNIFLKRKGGRGSPEDELYGSSAFHSRVITLLPFAVLLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEW1</accession>
    <name>F9WEW1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002068">
        <property type="protein sequence ID" value="CCD15827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15374" checksum="DB439EDAD45DEED8" modified="2011-10-19" version="1">MTRFLHTNRPLTSLRTNFSSLCMVPSHTTHAIFEAKGNQFQCTFHFLHPLVKGCLISQDVAWQRAHHGNKLLKLFPVTSEIGIFQFTLVILQLRLPLPHKHSLELSILVVVYVSRKCSVQLFCKFMEFIRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF84</accession>
    <name>F9WF84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002115">
        <property type="protein sequence ID" value="CCD15952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15960" checksum="91FA48F92854C719" modified="2011-10-19" version="1">MPQPFHRLPHNMDMENIILGYTKDCMAHDNSAHAEHISTESRLTSSIPTNELPLQKRKVTYLVEAPHHQRFEPRRHPLNAVSKHDIGRSLLVVHPLPGCFKSPSHPIALLHSPIRAYRMKKKHYYPYYYCCCHYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC2</accession>
    <name>F9WFC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002125">
        <property type="protein sequence ID" value="CCD15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09620"/>
    <dbReference type="OMA" id="WHFGQYV"/>
    <dbReference type="OrthoDB" id="755305at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="319" mass="36742" checksum="EA02E010679BE242" modified="2011-10-19" version="1">MASDSVPIIDVGPLFQRKEGVMQVARQIDHACRTWGFFYVVGHPIPREQLERVMETAKRFFSLPLEEKLTVDIRKSKHHRGYGCLNAENLDPTKPFDSKETFDMGFHLPEDHPDVVAGRPLRGPNNHPTQVEGWVELMEGHYRDMQAFALVILRALALAIGLEENFFDSKFEEPLSVLRMVHYPPQKEESQFPLVCGAHTDYGIVTLLYQDDVGGLEVRNISGEWVSVEPIEGSFVVNIGDMMNMWSNGRYRSTAHRVRITTVDRYSMPFFCEPNPYTIIECLEHCHSPDDPPKHPPVRAVDWLLKRFHETYAHRRAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT0</accession>
    <name>F9WFT0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16848" checksum="63AE5D58AFA933D2" modified="2011-10-19" version="1">MPKHTCRGDGTTPLPWWGPPRPLVGTPGRGTHSLRIRNSTLGGLIKKRGRGLSKIISPGFHSPLVFLLFFSKTPLFERISGFGKIPFFWQIFFLPNFPFLPNSPFCQFPFFAKSPFLPNSLFCQIFFFAKFSLFCQIPFFCQNSPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ6</accession>
    <name>F9WFZ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002208">
        <property type="protein sequence ID" value="CCD16226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11740"/>
    <dbReference type="OMA" id="QNCAPSG"/>
    <dbReference type="OrthoDB" id="1654829at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="358" mass="40904" checksum="3BC6630B8F8B6741" modified="2011-10-19" version="1">MNCYEDAEFKAALVWERHWQVVNNRIRFEDVNLENDWKVLKERIDMVGPLPRYVLADDPAYEDRLKGVNNALGLLPSDDFEYYMRVLDNPHEWHEDGTTHKLVKLVRCKVDNELVCRNRVTSIYVQKEIHRKMLVASIKVSRLREILSGGLEKCADLFEIAGLRAFIDKTTVDTLVKHLEHLPRGNEAKRESVLCQRGANGRVPTALSEFASDSPRQKLVTGRIYKPLATNFPLVDGFFVVEGVGLKTIVLVQVTKAKEHHTKKTTVNAFREYMGKVFEDWENIEKAYTWELIYVQHVDSTAIKKRQNCAPSGDAANDTDLALWDRIHQYQVTLSADIAAELIDRGIGLLQVPTTSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG82</accession>
    <name>F9WG82_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 474</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002242">
        <property type="protein sequence ID" value="CCD16316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12550"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17278" checksum="BEFCE6272C195EF4" modified="2011-10-19" version="1">MRELETGCTYKPLIPNFPLVDGFFVVEGVGPNTIVLLQVTKAKEHHTKRTTVRKFRQCMGKAFECREKVEKACSWEIMNVQHVDSGSIKKRWKCCTSGDAAGDEHLALWENTHQYRVSLNTGIASEFISRGSCWRRDPIRRVRQSRAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGJ1</accession>
    <name>F9WGJ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002278">
        <property type="protein sequence ID" value="CCD16427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13480"/>
    <dbReference type="OrthoDB" id="1662648at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390349" evidence="5">
        <location>
            <begin position="24"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="95"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="430" mass="46864" checksum="48265AA80F550863" modified="2011-10-19" version="1">MAFFVNMIAFPVFLCSFWVDASGKQNTAEVKSMDNSEQFALLCRIYNVAENPPIHHVDLPDPLKIVTEIDAINASFTEEKQPNETEQAENSTDAQVKPTITRKVITREVAVSQAILRRISHKAHTIVDEIRNLKATRDIEKVKANFDQVIFGEGMNESELCKGTLKGVNGRATACGKPGDGTKGNSAGKNLVVDFFCLCAMRTSVNGKDNEGISNVCGVEVGGKSKDVKHSWGDACPPTSSTMWASVKKGCGKLTHTNPKFAAEGHEILNDFLKHLEMGGVYRSGDSSGSNRKKGMLGTSVGTEEQKGVDLICDGSKGYTKSGGKPPGGVCVFYGHESEWDNIDWLLKFKTALASVDTLNNKTATIQQAIQKLETLLHRAEKIYETAKVISEIQNPVVPHNLPTAAKRLTAYSAARNNPHAHFILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY4</accession>
    <name>F9WGY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 573</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002351">
        <property type="protein sequence ID" value="CCD16572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14860"/>
    <dbReference type="OrthoDB" id="1706133at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="19463" checksum="96AC99B9A92AA675" modified="2011-10-19" version="1">MSWKCCWKASCHPDRINLYWFLKPLCAVVQEQNACFTLGDFVRNPRHCIPEANVCDALWQYLPYILWKFRLCATPLIRHFGPPETWQHWHWDSWKIYINMDDTPLEAIDEEIWCRCRRPQVPQYRPYHGVVLVEATPSFIQIPLRTVGYLVHIPITPRSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY5</accession>
    <name>F9WGY5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 573</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002351">
        <property type="protein sequence ID" value="CCD16574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14870"/>
    <dbReference type="OrthoDB" id="1716545at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17590" checksum="B52F4AC99930023D" modified="2011-10-19" version="1">MRHRNGPGVSNRVRRFQDPPCLRWHATNHPYHPLHNVRIRLIQLEKLPPHLPFPWPSTLWRPHIIDQPQCQHPELPQQAGKTFPYFFPSIGLHHASPRVPGKVSDAKPGNVRMHMGIGRLQETVQVDAFRNSNAFQRYLKNISLHGPGNDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH22</accession>
    <name>F9WH22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002362">
        <property type="protein sequence ID" value="CCD16611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15210"/>
    <dbReference type="OrthoDB" id="1661634at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="529" mass="58018" checksum="B72E1B939602F085" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB3</accession>
    <name>F9WHB3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_16100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002408">
        <property type="protein sequence ID" value="CCD16704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16100"/>
    <dbReference type="OrthoDB" id="1665665at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390334" evidence="5">
        <location>
            <begin position="24"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="91"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="430" mass="47175" checksum="A7CEEFA00051120A" modified="2011-10-19" version="1">MPCFVIVLAVSFVICSLVKDAVAQGAQVQQVDNAEQFALLCRIYNVAKNPPINHVDLQDPFKIVEGIDAINASFADEKQPNEAEQVGNNSYAHVKPTTTREAAVAQVLERITQKAHSILEEIQKVNATRNIEKAKSEFSQVIFGEWMNESQLCEDTLKGLGERGNACGKPGAREKGTYAGKNLVVDFFCLCTMRADKEKEGIENVCGVKVGGKDDTHSWGASSPSGSSSMWASIKKGCGSLMHTHPKSTKEGYEAVGDFLKHLKAGGLYRWGTTSKVDGSNRKARMLGTGVETEGNHGRDLLCDGSRGKASPASGRSNGGKPVNHAGICIYYGEQAQWEDDIPWLTQLKTALASVEAANKQTATIQRSIEKLQMLQHRTEEIYETTKVISEIQNPVAPTNLQTAARRFTAYNTAWRYHYPFILPCLLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHG5</accession>
    <name>F9WHG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_16590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002433">
        <property type="protein sequence ID" value="CCD16758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16590"/>
    <dbReference type="OrthoDB" id="1665678at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394775" evidence="5">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="44260" checksum="BA0C08BDC65DE1DC" modified="2011-10-19" version="1">MMKLFMVCLVVMGGWVREWGVMANTEEHVKEGDNREPYELLCRIYNVAQYPPIKPVDTKEYQKIVDDINALNAAVNGRERVNTQSEETKSAQTQLIGISQDAKKLLNEIKKINPEGEVEKARNAFNTVIFGKNGKDLSPGWLEIDPSRMAACGSKEKKGDSAGKNLIVDFFCLCAKHDEVNEWVDNVCGVSVGSGEGAGWGRKLYPIATMWDEVKKGCKKFSNQGVTSTQDGYSLYHYFLEKVKVWGNVKLKASGTVPKQGMLGTAVSTNRDTNFHCNGKKAVSTNRFNVGSGSCVFYGNHHLEENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADSQQEEEDTDDSPLAQHPNSDENENADSTTRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ9</accession>
    <name>F9WHJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002447">
        <property type="protein sequence ID" value="CCD16792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16920"/>
    <dbReference type="OMA" id="EEVGYLH"/>
    <dbReference type="OrthoDB" id="737235at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="45388" checksum="B31CC9AF676220F9" modified="2011-10-19" version="1">MNFVSLYRSLLKGVHAAKGNPHHLQDTRFILSYPLVEPAFYTTTLGSGVEHPGPLKGIDAQKIVQLCCNDLRRAFESVSFEMVSVTQRFIHMRELAWLKSRLENIVSEATEQILNEARAVASDLPNDDFLSEEVFLRHTHGSSKEVSKAEAAAGSAVKRPKGVASAGALGLRQEMFILQHRTQFPLVREFFNSFAADPQAIANVAMSNAKLQDFVRRNTSRTVTCKNGDVAVTIAVRPFDSSITRKPVGEGSPFSHAYRYFMVRFHVVPHDPSVLSVDVINSYFLRLDVASLELVEDVGYLHASGVWKLAQQVNARRGNMSGSPRNVSGNADDGGGEKSCEVPDEAARPAQPSLQSDPSLQFELSFINASDGPTVMKGQLYYTLTEKDSKLNSEMRVRVISFGNLLLLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS8</accession>
    <name>F9WHS8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 692</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002483">
        <property type="protein sequence ID" value="CCD16873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17570"/>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17685" checksum="FE8ED88D55E177AF" modified="2011-10-19" version="1">MLTERGFTLRDVTAVTPVEVALCLRELTLLPIKDVPPELLSSTDFRMTPLFPFTFHRGERRRDMGVLFFDGGKKAFVTSMRVAETILNVRNCINYFFQLSIADGNVGCFPDSVVDIIVQTISHPLNDITDRSCFIGNDPCSTWFSECGGLGGGDNNDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI43</accession>
    <name>F9WI43_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002526">
        <property type="protein sequence ID" value="CCD16988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18570"/>
    <dbReference type="OrthoDB" id="1698773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="24444" checksum="FBFE536C55599FAF" modified="2011-10-19" version="1">MFATRIPQSRTIDFQNKTASKERENNNNIKTQRRITIARELSKSKCKNRKRRWCPRRGLHTSVHKHKEPQECHPHKQTWHCELCFSACIAKGLGGGIPTRSFIAGASAGPVAFTHKNCSWHVSPLFASPGWRCDSQTWEDAAPPHNSVATTTTVWLQLGQKLSRKLSDHTWVPELKSPFTRGRNSSFSNGKFPFLKKKGKKKHPALRFCMHTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI58</accession>
    <name>F9WI58_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002530">
        <property type="protein sequence ID" value="CCD17003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031083">
        <property type="entry name" value="YTHDC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF100">
        <property type="entry name" value="PTHR18934:SF100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15234" checksum="3985C789FFF08E23" modified="2011-10-19" version="1">MVQTKGFQGLQRLIAARVEYMGEVIDGLTRLLFHRMTCEVKPSDEGVHESYPLTITRCGLKSIPQCTMPEKRFRFLKEFRRSLPSYRHKDVIVESVRRGAVVVISGGAGCGKTTQIPQMLYDEEGLFDKNLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIB7</accession>
    <name>F9WIB7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ01000000 data</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19200</name>
        <name evidence="2" type="ORF">TCIL3000_2_280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575315">
        <property type="protein sequence ID" value="CCC89460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002563">
        <property type="protein sequence ID" value="CCD17063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19200"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_2_280"/>
    <dbReference type="OMA" id="THDIGER"/>
    <dbReference type="OrthoDB" id="961408at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC89460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33144" checksum="1D6EA05647B6337A" modified="2011-10-19" version="1">MFSSATRATSCPLPQVARRLYVMLRVAAALLWVPHFSAALCIAHNSEEVFQVIVFHVLAMAVTYYVAVYKQSGDYLFIVSWAIGVLSGSAWATPRSHSGVIFHHSPTVVVSEVEVHKANSNILSIGSSGGSDGAVSALLTLSTSTEGSRLLWLAVSMLHGIIGGVLCKLKDVDEDRYYPTHDIGERLYVVVPFCTGQWLYFVLRHGWKGIVLENLTIILVLAIVGYTVLTYKLLMRYTPLAHGDVISFLSMLLTSSFGVVFTAVVVGNAFVTVLIIPFLKSLFSLNALVSSLGIVMEVIVYEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIH0</accession>
    <name>F9WIH0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_02190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01002587">
        <property type="protein sequence ID" value="CCD17117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02190"/>
    <dbReference type="OMA" id="QWYVVAR"/>
    <dbReference type="OrthoDB" id="257116at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390383" description="H(+)-exporting diphosphatase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD17117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="620" mass="64501" checksum="7EB338D45F2DC105" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW3</accession>
    <name>F9WIW3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_20950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002647">
        <property type="protein sequence ID" value="CCD17262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20950"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389194" evidence="5">
        <location>
            <begin position="22"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="38261" checksum="75843E69437B2795" modified="2011-10-19" version="1">MLFWMFLGVFVIVGRVGSVGARTESPTHHNKNEHDVLCGLLGVAVERWKTTNNPTAKKALSRAIFGHTNGGIIETLMEKLPNEYNEPGSRENACGSCTYSDGKHYPGWSIPHDLICMCTVGENGYPFGQNSNDNGTPTLCGRSATDFGCEQNQGNGNGCHGNKDWWKESSHHDGNGNRQASKHLNATWEKVIKPCLIGGEKLQLEVALKNLTGSRKDRETPSWASGHGKCNGVSGAVCVYYGTGCDKQYNNNSPQWWWDLEKALTTPNLTEAQLNSTTFLNASLDMDYNLEGVHGGHGVGTSSSSSSQQAGSTTHHPDEPRNRLASLFSKHDGTPLTSPFLWSLGAFVSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW7</accession>
    <name>F9WIW7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 840</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002648">
        <property type="protein sequence ID" value="CCD17266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20990"/>
    <dbReference type="OrthoDB" id="1708513at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24097" checksum="4012E2873E96CAAD" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGESPMSSARARRLFANWKACLRAAGGGEAGRHGEGSRGFRDQTGDTHNRARECQACHGKGGKFMFQLRRNCCVRLSGVCLQAKNSLIHFICGVPVVEIAVANDTPSALRNVSRGGGGGLGHPRSSKGRGPNARGLFACRVCKRLLKVCASRERHRIGRHGGATLPEDPPCMAALDAAEDAAAERRGGEERVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ00</accession>
    <name>F9WJ00_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 857</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002667">
        <property type="protein sequence ID" value="CCD17301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21290"/>
    <dbReference type="OrthoDB" id="1709701at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21190" checksum="30E3E918424C6234" modified="2011-10-19" version="1">MSWYTITSPRTIPWSMEKDVVEVLLDGVASADSINLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPVPPYQPYQEVVLVGATASFVQVPYSTVGYLVNIPVTPRPWPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH3</accession>
    <name>F9WJH3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002727">
        <property type="protein sequence ID" value="CCD17478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="RMYALDE"/>
    <dbReference type="OrthoDB" id="814890at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15509" checksum="288FB10576E07D3B" modified="2011-10-19" version="1">MMTAAVYGLELQACAISPLYYPFNSDSGTHRFLVGTSCFADENVIRLLTFQEETRVLECSAQWLYGGEEVLGLWCSPSIATPSLLAVATPTRCSVLRLPDVLTDELQRVVDFDVARGKVVWDLEGLQHEVNEDEAYVSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJW9</accession>
    <name>F9WJW9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002783">
        <property type="protein sequence ID" value="CCD17627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24330"/>
    <dbReference type="OrthoDB" id="1676775at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="35697" checksum="3F6F6131F1E62CB7" modified="2011-10-19" version="1">MAAEKAREWKGDIVFLIPGWSRAVYPKYCGSPHSGSGEWHRPATPRNASSPATDPGPSGPSHAGTNHHATTCFPVGQLGRHLLEHTLSGFLMVRIFGRGSPGNRRDCPEAWPNGEPESHTLPTETRPAARQPTCHTLPGARLLLASMRSRPSAASVGEGAAHMDSSRSLEEWRSVHLRGTAKTEAGPSIRPSPAGLGVAAPRARRFPSLPSPPASGRCASPTARYERSSFRAGAYAAGGHCGGPPGGGRGHIALLRTLHQVCQGPPAHRRLNRGVHGLEKVVQVQTAWVPTELQEHHPEIAWHGPKKETLPRDGEWRLRWRVVHRRWLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK21</accession>
    <name>F9WK21_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_02760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02760"/>
    <dbReference type="OMA" id="KLEACAF"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="62"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="471" mass="49416" checksum="7DF59FC25DAFB751" modified="2011-10-19" version="1">MDPRVEPAADPEEGSLPTGAVTGTPGAQGEELKPGGGQHHGDAKEGGTRTLASCITTLIPPGGMVSTVFNLSSICIGAGILGLPAAANSGGLIMTFIYPLIIVLVFVQSLYCIAAQVEKHSLKSYEGMARVLLGPRAAYAAGMLRGLGSFGACVAFVISVADILVAILQNSDAPDFLKSVTGNRLLTLGVWLCCMLPLVIPRQVDSLRYISTVGIIFCFYLMGVIVVHSCTNGLPENIKKIHLSGGPSDDGIHLFGTGNKAIEAPAVFTFAFLCQAASIEVYSSMAQPSVTRFTLYSAYAMAMCFVLNVATAFFGYLDFGSKVTGSVLPMYDPVSQPAIMIGYIGLVVKLCTSYALSMFACRNGIYNVIGRDPDTTAFWEHCAVMVVLSVIALVCGLFIPNINTVFGFVGAVCGGFLAFIFPALFMMYGGGFTLQKVGPLCYTATYALLISGVVLSVFGTVATIYGVATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK54</accession>
    <name>F9WK54_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chloroplast protein-transporting ATPase</fullName>
            <ecNumber evidence="1">7.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_02780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01002810">
        <property type="protein sequence ID" value="CCD17715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02780"/>
    <dbReference type="OrthoDB" id="374850at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="9">
        <location>
            <begin position="233"/>
            <end position="880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD17715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1734" mass="198255" checksum="91CC7DAA30273FEF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W396</accession>
    <name>F9W396_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000376">
        <property type="protein sequence ID" value="CCD11604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25750"/>
    <dbReference type="OMA" id="CFRRVID"/>
    <dbReference type="OrthoDB" id="1666331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="389" mass="43885" checksum="1A635D2E13A1FEEE" modified="2011-10-19" version="1">MNCYEDVEFKAALAWERRQQVANNQIKLEDVNIENDWKALEKRIYMVGPLPRYVLGDGECFRRVIDANSALSRTLDEDVERYVKHLSNKAEWYVDDTTDNIVKLVRVWKTCPEEARNQAVCTYVRGRILEEVMTSFAKTKFRSNVLVSFKKRCLSGLEASGLQTFMIGSVVTEVVQHLKYLPREGETERSRSGVLCRPAARGRVPISPHHFSSADTPLEIVVGCLYKPVENNFPVVDGFFLVDAVGKGVSLPEGAEAPTQTVVLLEVTRVRNQRTSTCKVRRLRERLAASFSNWREMESRLSYEIIYVQQANSAAIATRQRCGRSGTVSDLASERFWGGVDQFRVKLDAPIAKLILQEIYDAKITEDVAAIVRDLRGVNITAVAGADTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U2</accession>
    <name>F9W3U2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000473">
        <property type="protein sequence ID" value="CCD11816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27600"/>
    <dbReference type="OrthoDB" id="513193at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="23577" checksum="9A942413BC1C378A" modified="2011-10-19" version="1">MNENAKVQRLVDELGCLISEWTVNGVSERVAQQFSDLYRRFMLTVHHDLGSSIDKGPALATAACIPLWEMLHFYSGAFAPLQASSKALVIILLTSLYPKARDRRCLYQHLGCVGSLGFSSVPLNWNVPTKTEVIEDLTSDGSEQDGYSEIVNYVQNTLLVEEEILKTCSTVGLGSKVKTLMEDVLPRCYLVDQDSNVSETGMPSESAIVITRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4C2</accession>
    <name>F9W4C2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_29320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000540">
        <property type="protein sequence ID" value="CCD12011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1675024at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388646" evidence="5">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38269" checksum="38BB8DE601858C21" modified="2011-10-19" version="1">MMGMKFWIMIIIFFFMVDANGGGKEYNKNAYNALCDLLQASVRKWDEVMGRKKTDTLRKALRITIFGSKGSEDLDALRRGLPEDYKKGGADRNLLCGQQYRDYNGLNQPRWSGYSGLHDLFCLCTPGESGWPINVSGNTLCGQENSALEGGMKGWYKNTGGEVKVEKTWNTVTEKCLRGRGDTKGLKDALTTFMGELCTKNSCWVRKNSYQLGEGIPTTWSACDGTSSVGVCVAYYNATNPMPWWSSLKEAINADEQEQKKREKEEQKKKEVQKREESRKQENTELPQGPRTAALRSATLEVKEADQNNPENISYPLETLEEASGAIIAQPCSWLLNAIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G3</accession>
    <name>F9W4G3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000551">
        <property type="protein sequence ID" value="CCD12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29730"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394677" evidence="1">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="24993" checksum="3E149F4A033BD209" modified="2011-10-19" version="1">MVMVVVLWTGTASGTYTTGPNHNGAHHETLCGLLGAAAQKWKTTNHTVFNKALWQAIFGKREGDNLDVLSKGLPAEYHDPGNRQYTCCSRTCSNHGPYPGKSIHHDLLRMCTVGENGYPFNYGSDNSKTLCGRSATELGCEDGHGNGCQSGNVNNHGWHENGDHQNSAEQAKKHLNSTWVKVVSPCIEGALKNLTESRKDWETPSGARSHNSCNGVSGAVCVYYGNGCDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H0</accession>
    <name>F9W4H0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000553">
        <property type="protein sequence ID" value="CCD12062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29810"/>
    <dbReference type="OrthoDB" id="1726974at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18032" checksum="08675B105010E5FD" modified="2011-10-19" version="1">MSDLQCIPDYLYQDELGKSSEYICERNRPNVTMHFTGFGSGRKISAPGFLKKKTSFLGLSGAVSPYTCFSISRLLDSSNAHCQPPAFFPRPAPAARCRFCAVSLRRTASPRTSYGCCKDTELSREQIVCTVCSFCACWCFVVDYLFAIGTANFSGSRSVNELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K8</accession>
    <name>F9W4K8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000569">
        <property type="protein sequence ID" value="CCD12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30170"/>
    <dbReference type="OrthoDB" id="1713184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19760" checksum="775F2BB5A3E25B25" modified="2011-10-19" version="1">MVMHASYLPWEREAERSRASVLSRYRLPASIYSFEAADQQYRLEEKWLYKPGWKNFPIACGFFLVDAVSEGVSLSEGAEAPTQAMVLLKVTKTRYHHTKTSKVKRFLNRMAETFTNWDEMESRLRCEIIYLLHADSATIKTRQRCDSGGMACDAGIEEFCDGIGQLLVKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P5</accession>
    <name>F9W4P5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000586">
        <property type="protein sequence ID" value="CCD12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30520"/>
    <dbReference type="OMA" id="RSANTMY"/>
    <dbReference type="OrthoDB" id="1463460at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="39904" checksum="21491FA68565AD06" modified="2011-10-19" version="1">MTTSTEAAKVEKVRRTLASLGYYNPSTEDIALTLEQMGRVRESRDAQPIAHGLNPHQARASSHHEPRNTTGDLMGGDYGPRSGEGVESNTPADMWARRVGPPQSMGGDRAPYCTLRESRHKVSGGILKHDEAEQHNDTAGARPRSRGAADDGERRALRLSSGNGRREVRTKPRFRPMALHKTPEARLEQHIKHYERGLTATLAARYVGDSQDEFPSGRNEWVGDSRECEDGFCNYVDDYYEDGFDGNLAMYYGGRSHNMASPRALAPPNAVALDQRSANTMYSFTGDARYKYRSGSGLPLSTVLGPDGSTLRTRADPVRRGQQMRELWKKDKFLAQHGRKEDRWRVRQTMLNRTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4W9</accession>
    <name>F9W4W9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_11_8040</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31200</name>
        <name evidence="1" type="ORF">TCIL3000_11_8040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000624">
        <property type="protein sequence ID" value="CCD12216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.8040"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31200"/>
    <dbReference type="OMA" id="IDRNCAM"/>
    <dbReference type="OrthoDB" id="1566908at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="PTHR20648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC95357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22047" checksum="8CD57D8108EE5AE3" modified="2011-10-19" version="1">MKKVKASLPVEQTNQQQVHCDPSYMVCLESCDGHRFLIDRNCAMVSGVVQRAMQGKHCDGGCGLPQHAPCPIAADHGGAPNASPTPYTATLCTTPVDNATFTSTFASTSALSTASSEASMILGENLTVHVPQTDDNCSTTLIGSVRYNLFKLQEISGDLLDLAVQEMYHKYRYDSDPEKRPQESLHTAVEKHKFVALSVLLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W555</accession>
    <name>F9W555_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1277</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000660">
        <property type="protein sequence ID" value="CCD12302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31960"/>
    <dbReference type="OrthoDB" id="201734at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="720" mass="79237" checksum="3D28D1A54F83E737" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W591</accession>
    <name>F9W591_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1296</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000681">
        <property type="protein sequence ID" value="CCD12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32310"/>
    <dbReference type="OrthoDB" id="1713576at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20224" checksum="55152EEBAD8B460D" modified="2011-10-19" version="1">MKPLPNGHPRDVHDNLCDYDECHLHLAALLHKLEFLLSGNLPCVALLNYGIDSFYKLVGATLPSIYSGSRYTKLQFSSGHGNISPSNDTVAHLRLEKVFFKVPTRTPLQLQKKKKGFKTSCHSRTSIGPYRCISCLNTSSALTPPPRPVALGGTRGAGVAKIFGAHVYIPRSYKTNWEMFAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B7</accession>
    <name>F9W5B7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000690">
        <property type="protein sequence ID" value="CCD12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32510"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="195" mass="19146" checksum="8DD7C24AE1EDE45E" modified="2011-10-19" version="1" fragment="single">MYATAIRRTGVGLLACCAFRTVKNHPGVPTNTTTLWLCATVSPARLRSSNATTSPTTKSTIVPAGAKNCGGVNSLSLGNTAAAAVLVHTNGGAVGHGAKGAALPSITSAIAGAATGKAAGMTAPLGTRKRAAKKVPVEALVLRPTKVRASKSAGASNNALIPAGGPQSVVPGALAAGTSAVKGNPKLNKRSLAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5C3</accession>
    <name>F9W5C3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1308</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000694">
        <property type="protein sequence ID" value="CCD12374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32570"/>
    <dbReference type="OMA" id="RYQPFQR"/>
    <dbReference type="OrthoDB" id="1407492at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="439" mass="51569" checksum="29B85A767ECD8A2B" modified="2011-10-19" version="1">MGGGYGLSVGQIGAGRIRDSLAEHNWWVAYVLVKTMKQSEDCPLKEIPLREVGNSEEANLSERVRRSIRDKFAALQSMRSNEMQEALARERQLSYIIDELKKRSAESEMSQEAEREINQRKSFYLIKEGECMRHQVQLLDQKVLELQQKYDKDISRLQESLRVTQERLVEEKLSAKEQESKQEKAIQNLVTSLYVAQKEAHRHEKECSRLVTLESVLNESRKECRLAQAECRLWKYLLHYRDELVLHEREEFLNIVQKHMAERERVMQHSEKSRTQEVGCCIEAAISKDEYMCDVYHELKELALQLSSSHLELRSLRARRLLEAQELKILSEKREDLVAMFDYYKIKADRTQRENTENLAMLKSVNDAKLAFMLRQRDEEVMDELFMWKGAFLEGVKLMEALLKRYQPFQRGDEMFVSRVIEYVNGAAKMRESASVSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5M3</accession>
    <name>F9W5M3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000732">
        <property type="protein sequence ID" value="CCD12475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33520"/>
    <dbReference type="OrthoDB" id="1675025at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389820" evidence="2">
        <location>
            <begin position="19"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38110" checksum="EACADB44102D18B8" modified="2011-10-19" version="1">MMMKILIVVMVIIGVVRADEVGAAVTLTNHNELSHRALCDFLKVAVDKWKDVKTRDPADPLKKALKDTIFGYGSGDDDVEALKSKLPRDYDEVGSGLLSERSLWCGQQLDEDRVQQRRWPGHSGPHDLVCLCTAGENGWPVNSTSDTGSTLCGHNKDALEAGEKWWSGTNNTQKKDAIQKTWDVTVNQCLSGYSQETDLAAALQKFKDKIKKTTFEHETRYILGEGGTGWSPCNGNGQVCVTYYPNSTDTHTWWSDLEKALVQDEKIQKQRAEEERRKNKDDEKNLDSPKAEASISGPTTTNQTEKNNQESNLTEKLRKLNLNSGTPISQPSSWLLSALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5M5</accession>
    <name>F9W5M5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000738">
        <property type="protein sequence ID" value="CCD12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33540"/>
    <dbReference type="OrthoDB" id="1068066at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21058" checksum="26093E777A76264B" modified="2011-10-19" version="1">MSLYTITSTRTIPWSMEKDVADVLLDGVASPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPESNVCDALWQYLPYLLWKFRQSATPLVKHFGPTQTWKKWHWDSWKIYYDNDNMPLEAIDEEIWSRCRRPPPVAQNQPCQGIVLVGTTPTFIQLPYSTVGYLVHLPVTPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5P4</accession>
    <name>F9W5P4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000744">
        <property type="protein sequence ID" value="CCD12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33720"/>
    <dbReference type="OrthoDB" id="1736382at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17551" checksum="16922F634FD5E3D4" modified="2011-10-19" version="1">MRGLLSFKAKQSKLCQQVVRPYRSCFSCSSLFTQRGEEDGHRRVNEKSYDFFFTPTRLATVRLVSGCIDACAGAIYTSFFLYKRKATPEIIVNSNFFLSLFFFSYILLHHSLSLDNHCLNLTLFIAASPALISPFDPIPYLTATFPPNPHGPLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P3</accession>
    <name>F9W6P3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000903">
        <property type="protein sequence ID" value="CCD12850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16580" checksum="574ECDBCD4D727F6" modified="2011-10-19" version="1">MIWTTCPWKPSTRRSGVGVGARHHPHTNPARESFWWKQRRLSYKCRTPPSGTSFLYHFPPDHGLGYRTYQFYFNYPVVFEKTYIARNAFLIVDFFWEGLGEKRNDRKRRVMRGTCMSIVVHLWRGRVGGGRVRVASLGRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R1</accession>
    <name>F9W6R1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase B-like</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_37070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01000919">
        <property type="protein sequence ID" value="CCD12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37070"/>
    <dbReference type="OMA" id="NSMLRQY"/>
    <dbReference type="OrthoDB" id="724258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PTHR12370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394724" description="Phospholipase B-like" evidence="5">
        <location>
            <begin position="32"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="659" mass="72956" checksum="B1F842717CBC00AB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T9</accession>
    <name>F9W6T9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000936">
        <property type="protein sequence ID" value="CCD12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37340"/>
    <dbReference type="OMA" id="NIRNCWE"/>
    <dbReference type="OrthoDB" id="1655556at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="700" mass="79224" checksum="D79BC4FA50B4A8EA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6W4</accession>
    <name>F9W6W4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000942">
        <property type="protein sequence ID" value="CCD12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QANRMLP"/>
    <dbReference type="OrthoDB" id="1618852at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="121" mass="13128" checksum="51F89DD377EFC6BE" modified="2011-10-19" version="1">MFGRRVVSCCPIPKSMYSVLHINTKRQASRLVPPLVPLTPSIKCVAGTCMTTMGLTVGESSLMDLTSNSLCLSVAGPTSQFFMSGFSSNPILMRVISDTMCTYSVLLHLFGKLDVWLPSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y6</accession>
    <name>F9W6Y6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1536</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000948">
        <property type="protein sequence ID" value="CCD12943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37640"/>
    <dbReference type="OMA" id="KIPHTIN"/>
    <dbReference type="OrthoDB" id="1490701at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027968">
        <property type="entry name" value="JHY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15261">
        <property type="entry name" value="JHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="598" mass="64189" checksum="9FD87435FCF7D65C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W740</accession>
    <name>F9W740_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1562</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000977">
        <property type="protein sequence ID" value="CCD12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38170"/>
    <dbReference type="OMA" id="EQTHARD"/>
    <dbReference type="OrthoDB" id="1053338at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="1">
        <location>
            <begin position="207"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="305" mass="33786" checksum="590E953AF77A3B66" modified="2011-10-19" version="1">MFTGSTEKGKAEVKETPNLQDCLNHWRTYGWLSGRGGDPPAVRSRSFRPSRIVPRLYLGAAKDVRVPWELRERILPEKLLMIVSTCEPKGPPRLELRRFDSVAKGTKRVVRRVAVCQWEELERNVVVCSPGGGCSFEEATDLTTKWLRHALLALSFPEGSGDEERPVADGAADSCDVACGDGTDIFRAGVYAKLCLPWEDEKTFAVRPYFAVATALMHAVMEGLRGAVVCHCMAGRSRSAALTCALLLYCCCNDATWVVGKEQTHARDIVQTVVEFIREARLCVSPNEGFTRQLMDYARDLLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7C8</accession>
    <name>F9W7C8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04200"/>
    <dbReference type="OrthoDB" id="1668015at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394594" evidence="5">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="79"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43790" checksum="28DE6A875DD6C1A5" modified="2011-10-19" version="1">MMKLFMVVMMVMGGWVREWRVMANGEDSVNEGDNRGPFELLCKIYNVAQHPPMKPVDTKEYQKMVDDINALSAAANGKESVNTQSEETKSAQTQLIGITREAQKLLGEIKKVNPEGEVERAKNTFNQVIFGEHGKEGDLYHGKVNGVQNRITACGSKEKEGTGAGKNLVVDFFCLCAEPSSGDEVVDKVCGVSVGSGRESGWGGGKLVSPDTMWNQVKSGCQKFATQSVTSTQTGYFLHREFVDTISAGGNVKVGSLETSRKPGMLGTAVSETRESNFNCNGKKEITVRDKVGSGSCVFYGNRKWAENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADTQLEEEDTDDSPLAQHPNPDENENADSTTQSQRHSHLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7L5</accession>
    <name>F9W7L5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1626</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_39570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001049">
        <property type="protein sequence ID" value="CCD13183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39570"/>
    <dbReference type="OMA" id="ERLCCTA"/>
    <dbReference type="OrthoDB" id="1236198at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="G10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PTHR19411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="G10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="244" mass="27359" checksum="DF19B47C65B63530" modified="2011-10-19" version="1">MPKIRPGMKRPPPGFEVVNDKLDEYEAEMRLALSEDPGRAKPPLTAVQRVNGHKERMKRTETSATEKDSANLHSPSDADESEKPDPPLWRVAKINRERTRYVYNACHRERTIGEEVLDYCCEMNFIDAGLVRRWGLAGYERLCCNACCLPGAASEAARMVGKYAKRDKKDRRDCNNEVSGSTCICRVPTERRRSKNFSRCAVCGCSGCGSGEKKERRAETKEDLLTAKRARTDDIGPDEVEAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W4</accession>
    <name>F9W7W4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001090">
        <property type="protein sequence ID" value="CCD13286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="15348" checksum="F196B819AE7C2C39" modified="2011-10-19" version="1">MQKNSSNNEITTKNTLFGTKNKKTKKIFFLHFFTKILQKLLFHTGNAKKQFKQRNNHQKHTFRHKKQKNEKNIFFAFFLRKFGKNCYFTPGMQKNSSNSEITTKNTLFGTKNKKTKKIFFLHFFAKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D9</accession>
    <name>F9W8D9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_42200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42200"/>
    <dbReference type="OMA" id="DIEETWG"/>
    <dbReference type="OrthoDB" id="1666747at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390001" evidence="3">
        <location>
            <begin position="24"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="427" mass="46339" checksum="EF83E93F5BC12E76" modified="2011-10-19" version="1">MRVYGLVFVCLSWLALLSGVASSSNDNNGVCKLGDEAAAVLCAIAHLVEKAKEVADSYDLKDIEETWGNVQLHKEVVDHRVKNLPDIIERAKGNGVLTSQDAGKLEEAYREAHKKNTEQYEKAQEAKRIYNDAYKTAKDVTSTALGDGKTRQNCKSTASLLDIIQCHVKGEQSQGSSVSVSDVCNRKDYKQVSSVDVASLLTNCEGIGKSKKYCNGTGAALKEALEKWESQGTNNTDSRNIGNCNVKNDWEKHAQKAKDHMLTLDQQVQVIHDANLLTTAYFSVVDKMRDDVEKGKPMKEILENARKAGKEGAVVLVAKPHPSTGENATAASETGGSDKVEEEVKVNVKLDGLQFDEDESSLANSKDKFPKYYVYLLAVLVPVCSIALAVAIFCIIRRTKPAHAEKGIPVEGAAAGKSQDGGKTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H3</accession>
    <name>F9W8H3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_42510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42510"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="769270at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="451" mass="49245" checksum="5C457F0C002F8580" modified="2011-10-19" version="1">MLPISTPAAKELAKEFVDFIKEACTPFHAVEVLSSWLLKAGYNRLQEGEVWPKLLNGGKYFVTRNDSSLIAFAVGGKFESNNGLKIIGAHTDSPNLALKPRSKAGKGDYKGVAVQCYGGGLWHTWFDRDLTVAGRVFISSSNLEKRLVKLNRPIMRIPTLAIHLQSTEERNAFGPNKEKHLVPIIATALTESQDDKVSEHHNSHLLTLLAESLGCEPNEIVDYDLSVIDTQEPVVGGACDEFIYAPRLDNLISCFCGVKALLEADSSLDQDDMIRMVCLFDNEEIGSATSQGAGGSFVPDVIEHITSCGGLRATLVANSFLLSIDGSHAVHPNYQEKHEDNHRPLLHRGPVIKYNANMRYATNGATAAVIKSIAKKASVPIQEFCVKNDSPCGSTIGPILSSLSGVQTIDIGNPMLSMHSIREMCGTIDLLYLKNLVEAFFNQYKSCTVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H4</accession>
    <name>F9W8H4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15841" checksum="5EFE865EEA1CC798" modified="2011-10-19" version="1">MKRGVGIYRRTQPREFTRLLGMVQQTVSSDEMPKTLLPAIFRMNDMVKPAIADRQSLIVHPKKQDHQPFSDNFVVVSKSSCLHKPLSNNVALYVAGNGTQSHASCTQRAERPLVATLRNRTEKNGLTRGIFSSHRDLGRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L6</accession>
    <name>F9W8L6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1745</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_42920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001181">
        <property type="protein sequence ID" value="CCD13550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="52155at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033270">
        <property type="entry name" value="VPRBP/DCAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13129">
        <property type="entry name" value="PTHR13129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="SSF159034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="809" mass="91932" checksum="551D9B6483A22E44" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8M5</accession>
    <name>F9W8M5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_43010</name>
        <name evidence="5" type="ORF">TCIL3000_7_2080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575320">
        <property type="protein sequence ID" value="CCC91398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001184">
        <property type="protein sequence ID" value="CCD13559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43010"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_7_2080"/>
    <dbReference type="OMA" id="VAHISCY"/>
    <dbReference type="OrthoDB" id="914452at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC91398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="278" mass="31865" checksum="4701C4E4081F8279" modified="2011-10-19" version="1">MPRPAPRFAMGHTLAHRSNVGSQFLYTQKHGSRVTWYKKQYFSQRPFAIQRHRGSTPRILLDRSLWKSVWMTKLHLPDVNRWERVVNSQRVTDDRYALVEEEGAMHKVNWGLYCERLETELLAAQERLPQYTLLMKAVPSSWKKLDIDVSVLRGLSLREAMAQCKLSMRKGHQITFRVLEMAQQGAEAKGLDKEHLRVAHISCYPGPTDKQIDIRSKGYYAWKTKKSSHLILTLAEDPEMLLPDRTCIPYSSLMSMSRAGLSAQSVSLDVPAITADGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q0</accession>
    <name>F9W8Q0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001195">
        <property type="protein sequence ID" value="CCD13585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664217at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394779" evidence="2">
        <location>
            <begin position="18"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="435" mass="49205" checksum="374DDA57090885B8" modified="2011-10-19" version="1">MDLYELVLLVLVNLGESVDLSLPSCVCVRWCVGGLWVRNVSFLFCLSMKIKETWIIRKDILAIVVFMAMVMEDVRVYSYPDGTVFNDGEYKALCDVFQASLDLWNASRTSEKGLDKVLEASLLRALFWNTGNKHLNGITDTLTHDYKKLVNRGTRCGGCQTYKFYFPGSSITHDLMCLCTPEKDAEPFYGYYWFFYKENGFKLCGKGRAQMGVDLNHGWYVDKRKKGNNGLEKPWRAVFMGCFNGWKRKTVEWNQDIKEKVKNLNATMQNFTGILKQVNGNHKLCGFNEHNEADGSTERHMHARYDTCTRGREPWWKKLNEALNGKKPEDLLRERSANQPAPAAGEDTGEEFLEDDAEEEGNLESEGSATQAGSPSQGSSDNSTQTINQSSSNSTIGMLNTSASGNSSYPRFEMLRSNTLKTFPCSWLLGANFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R1</accession>
    <name>F9W8R1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001201">
        <property type="protein sequence ID" value="CCD13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43360"/>
    <dbReference type="OrthoDB" id="1711494at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="22677" checksum="700321481A93BC99" modified="2011-10-19" version="1" fragment="single">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGEFPMTSARAWRLFANWKACLRAAGGGEAGRHGEGSRGFRDPTGDTHNRARECQACHGKGRKFMFQLRRSCCVRLNGVCVQVKNSLIHSICGVPVVEIAVAKDTPSTLRNVSCGGGGGLGHPRSSKGRGPNARGLFACRGVQVAAPGVCHHGAAPDLEKPGPPLPGDPPLWATLNTSKNPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8U3</accession>
    <name>F9W8U3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1779</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001218">
        <property type="protein sequence ID" value="CCD13629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43670"/>
    <dbReference type="OrthoDB" id="1698692at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="24344" checksum="E281477FC852363A" modified="2011-10-19" version="1">MFILVAISTHPLALFHTALNSFAPSSHPHPPLHVLPVPALCLPLGGCTRGVGLRDTPWPGCFPRIGADQPLAMGHPTATCEWDACLWLAGPPLPAFGCGTHWCPVSHVFLLGTCLHSGHSRTSSHSAACFSHCDLQSGHLKYICLVIASTDASPACAFSNSHMTFSYTSLQWGHDSLTLSSSEPVMASFSCLSFRRFFKDTNDAYFLSQKGQGTLIPHAPMSGSVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8V8</accession>
    <name>F9W8V8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein TCIL3000_8_5280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_43820</name>
        <name evidence="8" type="ORF">TCIL3000_8_5280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May contribute to the rapid motility of the trypanosomes, playing a role either in flagellar structure or in calcium metabolism. Could alternate between a GDP-bound inactive form to a calcium/GTP-bound active form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calflagin family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001227">
        <property type="protein sequence ID" value="CCD13644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43820"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_5280"/>
    <dbReference type="OMA" id="YFELYEL"/>
    <dbReference type="OrthoDB" id="1340191at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003299">
        <property type="entry name" value="Calflagin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01362">
        <property type="entry name" value="CALFLAGIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC92306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD13644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22652" checksum="54B3FC67A69EAC00" modified="2011-10-19" version="1">MGCSGSKAEPASKGSACPEKAPADPRAAWERVRALLPREKDEKSKLERIELFKKFDVNGSGRLSFNEVCSGCERVLQMHELTTRLRDIVKRAFEKAKALGTKLKGRGSSDFVEFLEFRLMLCFIFDFFELTIMFDEIDKSGDTLISKEEFTNAVPKLTEWGAVVSDVEAAFAAIDANGTGAVSFDEFASWAATNKLEAFGDPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8W6</accession>
    <name>F9W8W6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001230">
        <property type="protein sequence ID" value="CCD13652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16266" checksum="2D42A70DB77CE238" modified="2011-10-19" version="1">MWDVNDFPAVSFFNILPVLKYFPHVLPEGGDCALLRVMLLRFGYLRQDIRLEFHTLHTKEAVHKREACSQRLVDTPRYQLLLRTVGLELGNDCGHASRCMNTGWCLASFLRGRCSKCLASVSAAPDAMEVLDPSSRRVIGSAPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8X6</accession>
    <name>F9W8X6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1794</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001235">
        <property type="protein sequence ID" value="CCD13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43980"/>
    <dbReference type="OMA" id="MERRVYY"/>
    <dbReference type="OrthoDB" id="669184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037696">
        <property type="entry name" value="CCDC77"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22091">
        <property type="entry name" value="PTHR22091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="336"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="406" mass="46542" checksum="0BFAF5234CDD435E" modified="2011-10-19" version="1">MCAVVSQSVAGTAPTSSPHVEMTAIGDDYVKLLLNTIKQQDVEKLSLLDRIESCLKPEQEEAQRLRHEVVLKNEELGKLKRELSEVRLMLQEERERTTRLMYESVVLHAQAEDNRVTISKLMKQNNNATKSKDSKSPDSPVFTTGGHHSTSKLIGQQKISLRQAVATRQGASAGDGAASQFDSPEADAFPPSGSLLTALRDEVELLKSLLDTQRTMYENEWASRLHEERELERLRSEATASHLATIERLHKLHQTSLADLIRTRHEMRIEQRQLRGSVDRLQAALNDTVTTLNEERRQHSASLKEQRRLANESATVVTERLRKELQERRALSAAQEKQHTALLAQREAELKELRAERARDKRRLRQLEERYRLEREGVHNEVNLMRQELRAMEKRVYLSNSQYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W994</accession>
    <name>F9W994_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1838</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001284">
        <property type="protein sequence ID" value="CCD13785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44860"/>
    <dbReference type="OMA" id="TINNGLW"/>
    <dbReference type="OrthoDB" id="1475886at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="298" mass="33161" checksum="153C3F439C4BDFBD" modified="2011-10-19" version="1">MESLASLKGIAMLRVDVPPYLLNHTALQHAFIVALVVAPLWAFLVKPMLHRHPHQGRRFYLFWWGQLSSVLQFLSTVVPLRLPSFTRRPSQPAEPRGRPNRQSSKKELGSSEEEGKRYATGGPAVTKVALDDLFRSPGFREWYGEHRQSLLERVRLRSSQHLWASIATLIVTLLGFFVLPLFTFSNNGKTMYAILRPLFDVPPLNIAALTRGNSKSEALYLAALYLRKLGEALLLLVATCTLFTTAFMPTGLKQTALFASAAFAVLVVEAARLERMAAGAGFACLLFPVAWRIVSVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9H5</accession>
    <name>F9W9H5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 186</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001310">
        <property type="protein sequence ID" value="CCD13875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04930"/>
    <dbReference type="OrthoDB" id="1743097at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="16998" checksum="1FDCF9B08B48DD30" modified="2011-10-19" version="1">MMTIXSCAVLRPTVYLRKSLSSADSFFEKSCLDCLTTRSYCISFTSAYCASSFACCTAFSSMLELSGTGAGVPSATLNTRQSTSNSFSLSSFAPTVSNAPNGTAIHVLQTVSGNPLYARPSKFLFLTVSKNALHLGKDSCTHAVYRLGLCGLRWNHFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I4</accession>
    <name>F9W9I4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1868</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001317">
        <property type="protein sequence ID" value="CCD13886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45750"/>
    <dbReference type="OrthoDB" id="1711881at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23626" checksum="498D64F770113872" modified="2011-10-19" version="1">MLFTCLHRGHSITSSSWSTSSSLGSAARSLILPSGCFLSGCFSNMLLFSHPYDAYVLQYQGHFNFTTLSLSLCSSSAFLPHVVSLPESGWSSAPAVSRTSRIPPHINMATAVPVICMERISFHICQLQRRLSSNTVHFHPVNHTRLAMRARHIAQREYDGVTLSCSHPRELRVLRIFFRCGLHWCTLDVVRDFRFHTTPSTFQLIRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K4</accession>
    <name>F9W9K4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1886</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_24190</name>
        <name evidence="3" type="ORF">TCIL3000_0_45960</name>
        <name evidence="4" type="ORF">TCIL3000_0_46480</name>
    </gene>
    <organism evidence="3 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001337">
        <property type="protein sequence ID" value="CCD13963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002777">
        <property type="protein sequence ID" value="CCD17613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24190"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45960"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46480"/>
    <dbReference type="OrthoDB" id="841770at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="206"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="494" mass="51283" checksum="E89D7396D694BE6F" modified="2011-10-19" version="1">MLFHTSQCGFNNVPVVSFAPFQAPMGSPPPPQLLGPQVTTFYADTIQTWQGPVQIGKFNSSPPASQGSASSTPPSLSSSGHSAHNSNAGNLNGFHSPSFGNSVLIASGNNMQHYHQQHNRNFSGISGGGSIPSSSNISPMPPVTMSPCTWNFSVPPASQPSQPIYVMLPPTPTPGRAGPAGAALPPTPTAEVPRRSNGMMYELGEWYEGFVKRYNPTRGFGFLTATHHLQIIPPNAGSCTGPRHDTEGENTEQPAPQSQPYIMKTPVSVGDVFVHQSYIRMEGFRALTAGDVVAFRVGKLSGKDAKQAVSVQVLGTTNATNGAAKDGVKAKASQDAGESDISELSTTQARHDSAANEDGTTGRGGPNLADGAGESASISMEMLFAQISGQSAVNDNTPVPSTFCEPASSLNPSTNEPRNDGGGDGGHGSYCGWTGDGVSGSGDFPLGNLLGGCVPDLRATDFNSGVNLHMQTAGWGMTSSSHGTPRPFGGLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9S2</accession>
    <name>F9W9S2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001341">
        <property type="protein sequence ID" value="CCD13977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46610"/>
    <dbReference type="OMA" id="CXIVQYC"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1021" mass="125503" checksum="90BD73B297480EEE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA88</accession>
    <name>F9WA88_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15763" checksum="E395B253E87D6526" modified="2011-10-19" version="1">MEGIVDDLQQAIDEHVNAYVHHKYKRSSDNRRPMIPDKTRVASRRTCTGVGMRHRSLSTESRTGTNPRQKYKNRGRLQTYERIRSACRSKSTPRQNQEQYTSSPAGRRRRRKNARARVRFQNAPKLVRLNKKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAE6</accession>
    <name>F9WAE6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001423">
        <property type="protein sequence ID" value="CCD14207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48540"/>
    <dbReference type="OrthoDB" id="1721089at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16309" checksum="A75E6209DC4B9163" modified="2011-10-19" version="1">MSQFSCSPITGSREKTKFAESYSNCFCVPLTWLYVSRMINMPELSFCIVWIHGVSWCYAYFCSGAPLRIALGVHLLGVWTGIILNVFLRVCTHPDRGYGLMSLFQTWAFSVELIANGSTARGEGNCSHRKFQDLSLLCAGADSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG1</accession>
    <name>F9WAG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1970</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001430">
        <property type="protein sequence ID" value="CCD14223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48700"/>
    <dbReference type="OrthoDB" id="976277at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39430" checksum="D0B8090A7CA8394E" modified="2011-10-19" version="1" fragment="single">MVRKKNQKHADRAVVVGPTTGNPSLGAKRPSRGKLARCLDHCVTTVQEKLGSGPDAFLASRQTGADFSRECLASLFKLASSLHSPRLPYYSRTLETSSAQHVTIEQIWGQMNMLLRPVLRRLKENIRRMQETSNGNEAPVTRVTGNKRGEGSADAKCNERASVEDVDACSQGTSQLDESDLDKEISSLLAKQRDAKKRRKSNGNGDESWRYVFGKDNEESETDVERSESLGDKDEEDCQVAGHRRQRTRARGEVRGENFWDGDDQGQMDEEELEALKEMYGEDFVPHEDEYFEDEGDDMDVDDPLLEEDLKWDDPTAALDEEDSGTVAGGKRGYVEDDNILEDEEGFEGDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAM4</accession>
    <name>F9WAM4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001454">
        <property type="protein sequence ID" value="CCD14294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12326" checksum="C69AD5AE58B62A41" modified="2011-10-19" version="1">MLEDLMLGSTAYARSTRPLRRSCASSVSKTLARSGATCCCCLVPPAVDHCPKVVLVLPKVQGVPQWVGLSWPIHRKLCRVTGCLLHAFSCGFSGAADLDAVARAGYGWCHLALAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW3</accession>
    <name>F9WAW3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_50030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001489">
        <property type="protein sequence ID" value="CCD14385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50030"/>
    <dbReference type="OrthoDB" id="1672073at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394819" evidence="10">
        <location>
            <begin position="24"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="13"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD14385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="388" mass="41916" checksum="D71D8889A6B680D9" modified="2011-10-19" version="1">MALRFMLWWIIALLMLLAEDTLGTGPRAIPTKAGAAICTLSKTLKDVTPWVTQQVENGAAKITHLEMKLLEWQSKFIQSKSKGIGSETCKITGLLFRQVRKEIEKARKEVEKLEREASKAAAFAANSAGRLDEFMTVFANAKGGSSNHCLGDGKAATAGELRDCFGWEDFSEQSLVDIGERVSEQEPNLDSKIEGIKHQSLKDSFNGGGSAGCNLIKGASGGILGKTNLEKSLWWGGGILSIGPTYCGKENIVPGEIVNATGNKATWTADPASQIVHLKNASDAFKAFRAVQETIQEKVKSIEDKIQSCMGGKESGENSTEQNVTEPTVTTEETPASLTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPITQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ2</accession>
    <name>F9WAZ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001506">
        <property type="protein sequence ID" value="CCD14418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50340"/>
    <dbReference type="OMA" id="CENDLES"/>
    <dbReference type="OrthoDB" id="385320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="536" mass="59177" checksum="6B5D3E0E4D54C549" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBB2</accession>
    <name>F9WBB2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_51500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001558">
        <property type="protein sequence ID" value="CCD14543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51500"/>
    <dbReference type="OrthoDB" id="1678535at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="37"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="37169" checksum="65040AB04700316E" modified="2011-10-19" version="1">MKMWCGEWCSEGTKDHNKEAHHRLCRVLQEAVGKWGKGGTDLSEPLKEALKQTIFGYNSGETDVKRLGEELPNDYNDLERPLLSLRSLWCGQPRSEIQRRWPGHSAPHDLVCLCTAGKTGWPINETSHGATLCGKDSDSLGSSGNNGWDSSGKGKVKDQIEKTWEKVVKDCLQSVGQGNRLRETLDTFIAELNRTTSEGYGDLSRLGDGSFHSYHGCDGTPQLGVCALYYRDYKDTIPWWLQLENALEEDKKIQEKKKLEEEEKQRKQQEKANKQKEPRAEPVKSTQPITQDTAKNESDTLSEKLRKLNLTSGTPICPPSSWLLSAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBE4</accession>
    <name>F9WBE4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2094</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001568">
        <property type="protein sequence ID" value="CCD14576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51800"/>
    <dbReference type="OMA" id="YDAFAMT"/>
    <dbReference type="OrthoDB" id="1568870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390104" evidence="1">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="17428" checksum="552AD570A10C0E8B" modified="2011-10-19" version="1">MATWRSLAFGLLVCCALLCSDVHVTALTLHRPSYLSQRKMRSAEAGYGPPPMSGRSYRGKVVAVETKVLCDDGTAKTEWVDAILITRGGGCSQGRQALRAQSLGAVGLLVTDDGVGSEDEAEVDIPVERISKNDYASIMVALNNNIVVEATLGIPLNVLRYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBS1</accession>
    <name>F9WBS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001621">
        <property type="protein sequence ID" value="CCD14705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05560"/>
    <dbReference type="OrthoDB" id="23087at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="784"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1365" mass="147684" checksum="6197B856E310D655" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCM1</accession>
    <name>F9WCM1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001738">
        <property type="protein sequence ID" value="CCD15015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1686745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="29233" checksum="266374BB38207B5B" modified="2011-10-19" version="1">MQQQLEHLQGIIAQQAAQLEEYARTNATLRQQLTGQGVGVHTEEGERHHGKQDTGNVKRMDEYAWKGFPPHAPRPSSGGVGIRGIKELRGNSWMSGVRPEYKYSYISECDGVSLEDRNPEQLIAAYQYMSPTAATPGPAYTEAWKNFVSWALGLRSEGISEGHLQLGRQLYNQLRTIQTVKDHPGVKIEDIREAVEYPHRKDDVFIQAALKAKRHQTAIPPGRAQCFTCGRVVHYSSSCRVFKKKPESHPTNGFRPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCR9</accession>
    <name>F9WCR9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16558" checksum="7BE9A9F4C7A9E404" modified="2011-10-19" version="1">MEANISQTTRELKGKGLWTLEDFVCNPNAVLMDLVVRRVLNRAVRLACQEPLPHNVEAEEPVDPHIFTLPPFFISDNQGGSCQGKVRVEYCEKCVKELKNPGHDEKGLVPKGTKYKKRRSLRNSRVAVMFSHEFFSQLISNYEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC5</accession>
    <name>F9WDC5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_06010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001855">
        <property type="protein sequence ID" value="CCD15278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06010"/>
    <dbReference type="OMA" id="CFSFCDL"/>
    <dbReference type="OrthoDB" id="1349253at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="451" mass="50233" checksum="E3E7324D11B29CF4" modified="2011-10-19" version="1">MHHQRLKNKRTLGVTTGHEASQAESTYLPRVGEGSWHPAGSGARAVPLRTRTVASQRLRIDTYHDNKSMREALEQLKRMCGFLPLDDEEEINLMCSSSSSGRNGARHQFNQLPGHLVIYCFSFCDLPSLGQVSRVCRRLGTFANAHHLWEAHAQRLNKPTKGPLTAREDLRFEVWGRWNEEIERHRQEYEELERRLQERAAAERATVVDVDTLLADSRRRADGGGGGGSYRLRGGNTNVGISGDSRSAVGSRSDAEVEELYAQVQQLEATKQELLRAVHSLKETLAQQREEVQEVQRKVEISMKGESDANVAAGTDGSAHTSGATAALTLNDIFNFERRICRLVLSTVPDLPIVLRRGIDDFSVLEMLVQHGGGDVGSCVRQRWNAFKSFFPPVSNDYCTLRLHLLSGESLQASRAEGACERVSGVIRRMLAMSDDEITQIVMQTSFPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDF0</accession>
    <name>F9WDF0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58340"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23381" checksum="917EB95B0A7353BC" modified="2011-10-19" version="1">MKWTFTCPAEVEVELAVVELVRASLEPLETARGFFRSLLHGARQYDAQDGRTLTTDTLQKAMRQVVFEDEGGGDLQTLAMRRWTTTLRYALDPETAMHEFLLAFLGELHTLDRQVGNHRGADAFYKAAGRIVFGEARPSERDLQTLAIQYVARSVLQSEDPEKKARELLGGVLHEARHRDRERHHHQGEEALLKAMEEILQKTSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDH8</accession>
    <name>F9WDH8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_58610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001870">
        <property type="protein sequence ID" value="CCD15331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58610"/>
    <dbReference type="OMA" id="FADQAVN"/>
    <dbReference type="OrthoDB" id="935804at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020793">
        <property type="entry name" value="ORC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="PTHR10763:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_AAA_core" evidence="3">
        <location>
            <begin position="57"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="436" mass="48738" checksum="F6C4AF0777709A69" modified="2011-10-19" version="1">MKRKRARSTNYTSALRDGIAALSVSNVMASKGFVCRNSHVNAILDFLKDKVHPVMQIFGMPGTGKTASVNHALARLASSAPAGCRPTAVFLNGYIVQKTSDIYWTLNSHLSRTRLGRVENCSTDQCPALIEKRFKHGWGDSSPPLCVIVIDEVDKVLKKHHKAFFKIVDWLSLPYSFCKLITISNSMELAADAKTRSRLDITKRLVFEPYSLSELKEILLKRVGHIKPTLFADKAINYLCNQTASHYGDVRRLLQSASAAICGFMMKIEEDYTVPLGHDGMLTVRDVHAVVRQIFHDRFVEFIQNIRLPILFISVAVIAVETARAFQSNSDESRIPIDSLFIATRRAQERFGSALGETVIVPLGYCAYLDVVEMLREVALIDISLGDERIPVKTAQSLLEATEKAYASMLQPFQTVIDSCKLHEIFGDKISPLFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDT7</accession>
    <name>F9WDT7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_59610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001913">
        <property type="protein sequence ID" value="CCD15441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59610"/>
    <dbReference type="OrthoDB" id="247931at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="549"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="589"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="427"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="614" mass="70912" checksum="F2143CF270885E10" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDW7</accession>
    <name>F9WDW7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_59900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001922">
        <property type="protein sequence ID" value="CCD15472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59900"/>
    <dbReference type="OMA" id="NTTHIEQ"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390198" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="880"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1225" mass="135247" checksum="A823AEA2E6315152" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY4</accession>
    <name>F9WDY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_60060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001932">
        <property type="protein sequence ID" value="CCD15489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60060"/>
    <dbReference type="OMA" id="ISEMHEP"/>
    <dbReference type="OrthoDB" id="1442450at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="48757" checksum="E20B43D2BF5E9B5E" modified="2011-10-19" version="1">MPGSCKVNAASTTDLWRGEQMMNKLLWATGAFLCVFLFICKAGRELNMKRRVLRAHANKRRMRLISAEHGLCLDGYNILCDASFLRAISSAICNHNLGRGCGDPSAVRSSPQRTLMSVMYQTFNAATSHTPQGAVAEGAEQPKLKGMTLSLYYLPETATTLRRVVRPGHGEKNAATQTGKCNGGMRASEKGDVSAVAEVLLKGLERVRYKNPDLTTDATQPRNEAKAIAQFIADVKAGQISHYSIREGKNSHFFFVATQSHDVRRLLPAEAALIRFTAPPAALWIERNGDSFDYATSSDGSGRSGNWNRSGESSREIANGSAKSRNRAVVGPREGGKELSAADAAFMRHLSPDLIPTRRNEANLHRCNRGDTTKSGNLGVGTISCNGGDGQQKAAAPVIATSNSKGTTRRLYRKGKARGPNPLSVKTKRRREVLRVEVSHQQHKKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE06</accession>
    <name>F9WE06_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_60170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001936">
        <property type="protein sequence ID" value="CCD15511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60170"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390235" evidence="5">
        <location>
            <begin position="17"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37046" checksum="23022FFA59ABD85D" modified="2011-10-19" version="1">MVKYLMVMMVAVGVCASSDEKNHNGEEHLALCSVLSAAVTIFQSGRGGPTLQKALRRALFGKENGVGDISTLLAELPRTHHNPESRKSWCGECRYYGDPYPGWSIPHDLLCLCTVGENGHPFNSYGSVSQLCGRSVTELGCDHGQRDECHTGQGKGWSTSSTGESARRHVEATXESVVKTCLKKGLNLTVEEARKTLGEKLTVEEHRSAAWERSHYYCGGDFSGGGICVSYNLCGKNGYLKQPHWLEDVYDALLTANFNLPPSYLNTTGFSNTTFDEGEDGDERGPNGDSHNGTHHGSSSTRRRRKRRNHAVSHLFKEDGTLLTHPLLWILSAAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE35</accession>
    <name>F9WE35_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MSP-B1</name>
        <name evidence="15" type="ORF">TCIL3000_0_06380</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL3000</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06380"/>
    <dbReference type="OMA" id="IRIAVFM"/>
    <dbReference type="OrthoDB" id="1310134at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="PTHR10942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390207" description="Leishmanolysin-like peptidase" evidence="14">
        <location>
            <begin position="40"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD15541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="558" mass="59679" checksum="03DA0A95F8B7DC55" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE36</accession>
    <name>F9WE36_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_06390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 9"/>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06390"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="OrthoDB" id="837479at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="10">
        <location>
            <begin position="230"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD15542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="581" mass="66193" checksum="23BABF99BA215BB1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE42</accession>
    <name>F9WE42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_60400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001949">
        <property type="protein sequence ID" value="CCD15548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60400"/>
    <dbReference type="OMA" id="QQTHTTM"/>
    <dbReference type="OrthoDB" id="1202220at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="278"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="367"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="665" mass="71446" checksum="F56047E95E27DBB8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE98</accession>
    <name>F9WE98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2449</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_60900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001963">
        <property type="protein sequence ID" value="CCD15604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60900"/>
    <dbReference type="OMA" id="WVINATS"/>
    <dbReference type="OrthoDB" id="271662at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000967">
        <property type="entry name" value="Znf_NFX1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00438">
        <property type="entry name" value="ZnF_NFX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NF-X1-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="NF-X1-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="732" mass="81082" checksum="7059E5A044449D3D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEE2</accession>
    <name>F9WEE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_06670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001999">
        <property type="protein sequence ID" value="CCD15649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06670"/>
    <dbReference type="OMA" id="VMEVVDY"/>
    <dbReference type="OrthoDB" id="933605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="Extracellular_endonuc_su_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="PTHR13966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease_NS" evidence="3">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="NUC" evidence="2">
        <location>
            <begin position="2"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40834" checksum="A3CA2448F7FA6F28" modified="2011-10-19" version="1">MGFAASLNYERRIPNWVLEHLPGIGPEGGDVSEATRDGMKFFADKTVPALFRVLPNDYIGLDDKGEACTRGLSRGHLAAAQFHKRTTEELAETFNMNANTVPQDMTMNAVDWMRLESLTKKLRRHYENGLWIVTGPVFHPRFVDGDARAWRWAEWPQRPAALKPAEYATLNGDEVRHQGSAGEMRKRHKVVCYEVVGRHNVAVPTHLFKVVLGERADGSHEVAAFLMPNEPITVEKPLVTYQVPVAHVEWLTGLEFFRQALNNDVSRQRTLQGIDNLPNICKRLTCEARVGGMFQVYRDVARLRAAGSLSELQKVYNAFLTEQQNRCDGTANKVVTLNEVVAHEYRERMKELVGRREDGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK9</accession>
    <name>F9WEK9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002031">
        <property type="protein sequence ID" value="CCD15720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07320"/>
    <dbReference type="OMA" id="MAVRHQH"/>
    <dbReference type="OrthoDB" id="1529911at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="22188" checksum="69FD7EC4C87B7EBD" modified="2011-10-19" version="1">MPRVVWQRFVHRSMIPPQCTQRLSRYFLSTTAGVNDASAAGCGCGSGSAGGGLAGDSGLGGPGAAHGFHVDPRRLPNTIPGIGREELAARLEKQQREFARKYEETRADDLVREIDTMRRAMPPEEFKRFLRGIEEAEAKDAREAAKTSAMSPMQLYRYQQRQRRRLQLQLFAKTVVIFVAIFGCVFFLFFFFFFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN2</accession>
    <name>F9WEN2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002040">
        <property type="protein sequence ID" value="CCD15743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16525" checksum="6D2B2D25450FC288" modified="2011-10-19" version="1" fragment="single">MHVTARLKALWRCFMHVPVQWGVAGGEIRPSARVASPHTQRSAHFHPHCVNTAPSAAVQHMALKHLPCHVMLSPPLLGVPLRTPLHYPHNSCTAALPVSQRVTTARCVRHQTPPHHEASHRHTMCHNSHTAQIAQTKTQRAETMRFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEV6</accession>
    <name>F9WEV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002067">
        <property type="protein sequence ID" value="CCD15822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08230"/>
    <dbReference type="OMA" id="KNLAKAW"/>
    <dbReference type="OrthoDB" id="103110at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="668"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="837"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="975" mass="107813" checksum="5665DAB1DA356BFB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ5</accession>
    <name>F9WEZ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_08580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002082">
        <property type="protein sequence ID" value="CCD15861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08580"/>
    <dbReference type="OrthoDB" id="1670832at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390243" evidence="4">
        <location>
            <begin position="23"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="409" mass="43798" checksum="8A1782F345CF5837" modified="2011-10-19" version="1">MIFSVLCALLSLLLSHPNEVPAVNANSVKPLSDEALNVVCALKGYTDFVRGHTASHLLSTTKEHEASAAHALAKVRQYSSDINAMLTLRGTETDASNSTERGKVAVALRICNEAERLVSQENANAAQAREKAERAAKNAATSATKAAGAPNGGGSTGLQQLLDRQCGDEFRGSKSCECVRRHDGGSLPDGVGAVDCTHDGPKAAYKRVTSAKMAATMEKWESLKPSSAESKRSGCRGVDTTKYLCAELEGWVPSFRECLSQMTLLERALEEAEAAKKAAEHEWAVIHHLYTEIKGGKDSESAALSADAKRRDLKRIALEVRGHAECDALGLSEATEVWEHWGPETEGEKRQSPEAGRGQANKSFLWLLIALVPGIVLLISCLVYLVCICRRKAAATEPAGGTSTQCEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF56</accession>
    <name>F9WF56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 351</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002105">
        <property type="protein sequence ID" value="CCD15924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="853"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="872" mass="95418" checksum="3241D5F4A23A00C6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL2</accession>
    <name>F9WFL2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_10510</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002157">
        <property type="protein sequence ID" value="CCD16088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10510"/>
    <dbReference type="OrthoDB" id="1661957at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="31"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48514" checksum="6D16009335902CC8" modified="2011-10-19" version="1">MPLRCETELNRGVMTLFKSRISFATLLLPTWLSTASGQLKEGYNAKQYGILCDIYNVAANPPTSLYDAGQVEKIRNEIDVINASLGDDSWFSHISETGSNVSLTGEYKDQNNNGASNWNRLKNAVAKVHTNSTTFKKIPSTSPSVKLAQKKLKNIIEQVEKITREIRTANTASSLDGIKKDFDEVIGRIGEETTTFDRAAECGPGGFGAAGSNAGKFLIVDFLCLCAKPTWSWTLPNVCGPDLRDNRWDKTGEDGKGTCKPDERGRETWKILKEGCENRGRPETADPAAGYTALGEFLSAISQDTATTDKNKPGIFGSVYNGRGVVDCQDGKSGCTGRNCPNNGACVYYGENRKDGGKDIPWVQKFKSGLEKLEKIQSKSFSIQRLIGHLEMLQMRAGEIYEEATTSINLQRENLEEPAAHNTTRSHSQHGRLILPWTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP3</accession>
    <name>F9WFP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002174">
        <property type="protein sequence ID" value="CCD16120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01340"/>
    <dbReference type="OrthoDB" id="1670264at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394741" evidence="5">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="43"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39241" checksum="114A2836FA3FF71A" modified="2011-10-19" version="1">MMKVWVVVCFLFMGKIFAYGAEKNHNGVEHDLLCKVLKAVVYKWVKEESTLSEPLKKALKQTIFGYGGGGTLEELKKSLPGDYKKEGADRGHFCGQQHETSGYYDAQERWPGHSAPHDMVCLCTTGEKGWPVNESVVGTENNRLCGQLKDTLGGGKDGWGSQKSSWDQTSRNFVTLHDKGENQLEATWQNVTSKCLDGKQEDLKDALKNFIDKLVNRPQDTSNPNIYRLGEGDFSEPVCNGNKKVCVMYYPNSTETKTWWVDLEKALIEDSEIKKQREEEERRRQQEDAENKNSAQAEALKSGTQTTNQTDRPQNDNITDTIRKFHMKSGTPIYMPSSWLLSVAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT3</accession>
    <name>F9WFT3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11120"/>
    <dbReference type="OrthoDB" id="1701661at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="221" mass="24053" checksum="191DF27286CA1309" modified="2011-10-19" version="1">MDHCKGIGSRKTYCNGTGAALKAAMEKWHGMGANETSSGTGKRKVGNCTVSNAWEKHALNARDHMLQLDHIVETVHHANDQSLAYLSTVWQIREDVKHGKPMKAIVANARKAGQKGAQVVVEKTGDTSPNASHPTQGRKEEVQVTVQLEGLKSLEEEDHDPAHSKESFPKVYVYLLGLVLPLCCLIVCLTLYCVLHKALPRALTPTTRAASPSKAPRCIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFW0</accession>
    <name>F9WFW0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14874" checksum="917890B7E1DFEB90" modified="2011-10-19" version="1">MLGAAVAASGESDFNSNGKSSSIRSTSSAGICVFYGTEKWDENIAWLKKFKKCPDILDTLQKKTASTKKHLKIYQGRAEKNYKNVRAASELENPEEPAQDLALSEETNTNNTTYSRSHSTVFFLPWIFLIKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFW9</accession>
    <name>F9WFW9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_11480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002192">
        <property type="protein sequence ID" value="CCD16199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11480"/>
    <dbReference type="OMA" id="CEADIAS"/>
    <dbReference type="OrthoDB" id="630576at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="PTHR12895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="732" mass="80468" checksum="144387F5D21E75BF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ0</accession>
    <name>F9WFZ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 441</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002204">
        <property type="protein sequence ID" value="CCD16220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11680"/>
    <dbReference type="OrthoDB" id="3322at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033305">
        <property type="entry name" value="Hydin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23053">
        <property type="entry name" value="PTHR23053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1564" mass="173507" checksum="AF1DEED703820909" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG24</accession>
    <name>F9WG24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002221">
        <property type="protein sequence ID" value="CCD16254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12020"/>
    <dbReference type="OMA" id="PYLERKT"/>
    <dbReference type="OrthoDB" id="1656789at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="628" mass="72133" checksum="1B83FF7ACB77FC48" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG92</accession>
    <name>F9WG92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002248">
        <property type="protein sequence ID" value="CCD16326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12650"/>
    <dbReference type="OrthoDB" id="1711125at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21227" checksum="69090B04F279D5F5" modified="2011-10-19" version="1">MQTHILNTPRRIPWSMERDVADVLLEGVTSAERINLYWFLRPVCPGLTVELARFTLCDFVRNPRHCIPEANVCDAVWQYLPYLLWKFRQCDTPLVRHFGPPGNWKPAQWASWQIYINMDDTPLEAIDEEIWCRCRRPPPVPQCQPYQGVVWVGATASFVQVPYPTVGYLVHIPISPRPWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD2</accession>
    <name>F9WGD2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002260">
        <property type="protein sequence ID" value="CCD16366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13040"/>
    <dbReference type="OMA" id="EWVQCTA"/>
    <dbReference type="OrthoDB" id="1671727at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="38296" checksum="774A3CD93F4980C8" modified="2011-10-19" version="1">MYGKPGGSGSMYGMGRPGGMGSMYGVGGRIGSMYGKPGRSGSMYGKPGGSGSLYRQTGWIRNPCTANQVDRAPCTANRVDRDPCTANQVDRAQCTAWDDQEEWVQCTAWDGQEEWVQCTAWDGQEEWVQCTAWDGQEEWVQCNAWDDPEGWVSCTAWDGQVDRDPCTAWDGQEEWVQCTAWDGQEEWVQCTAWDDRQEWVQCTAWEGREEWAQCTAWDAQQEWAQCTAWDDQEEWVQCTAWDDQEEWVQCTAWDGQEEWVQCTAWDGQEEWVQCTAWDDQEEWVQCTAWDVQEEWVQCTAWDDQQEWVQCTAWDGQQEWVQCMSEGSVLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF6</accession>
    <name>F9WGF6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002267">
        <property type="protein sequence ID" value="CCD16392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13160"/>
    <dbReference type="OMA" id="HTFESDS"/>
    <dbReference type="OrthoDB" id="594141at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1157" mass="123443" checksum="C8FABCA4B73615BC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH2</accession>
    <name>F9WGH2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002271">
        <property type="protein sequence ID" value="CCD16408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13320"/>
    <dbReference type="OMA" id="NVIFSIC"/>
    <dbReference type="OrthoDB" id="1197424at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="36754" checksum="A0FF864532CD08B3" modified="2011-10-19" version="1">MYSVTVNALHRNSARSGKCTTSHCLRSLLLFVVLCTILVVLCFTEVLVDKSTQSVAKEVYINPKYISVNTLIIVPGHGVLKTARGYEWRNNSRWCLESHQLRNDVVLPFCFASHIKRAVEILKTDIVSSVVIFSGGQTCSAAGPRSEALSYYTIAEETGLFGLFETNVDVENILRERLFTEEFAEDSYENLLFSVARFCEITGRFPTSIVVVGWKHKEERFTKYHRKAIRFPRSRFTYVGLDFKDAAPFATSDLPYMMAQPYSDTIALSFVTKDMYLCSAGKQTRRKRNPYSRVAPYTLSCPPLRALLQHCGPHLISSELTPWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGJ0</accession>
    <name>F9WGJ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002278">
        <property type="protein sequence ID" value="CCD16426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13470"/>
    <dbReference type="OrthoDB" id="1676280at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390306" evidence="5">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="38073" checksum="0D0E47947B2900EE" modified="2011-10-19" version="1">MMKYLLVLVIVMVVSVKAEEMDHNKDTHKALCRVLREVVGAYQSGSGSEALKKALKKTIFGNETGGDLETLKGLPSDYDDVLQDVDSRSFACGQPRNHWEEYKSVYQPRWSGHSAPHDLVCLCTVGHKGWPLNGTTPEKEKEKLCGKSEAALGGNKEGWDSIEHDKGKDQIKATWENVTSECLQGVGKGETLKDALKGFTEKLVPQPIKGQESRKQLGEGKPDEIYACTGSKTYGVCVMYYPIFTAHTWWVDLQKAIQEDEKIQEQKKRDEEKEKRREQEDAENKNSAQEEALKSTSTTTNQTAAPNKDTLHEKLRKLNMTSGTPIIPPPSWLLRVALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH79</accession>
    <name>F9WH79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_15750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002394">
        <property type="protein sequence ID" value="CCD16668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15750"/>
    <dbReference type="OrthoDB" id="1672433at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012903866" evidence="5">
        <location>
            <begin position="16"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="75"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40179" checksum="4790DC24FF1BAA7C" modified="2011-10-19" version="1">MCMVCLCMLFPFSLISVLFLKVGEKVKMTRMMMVLCMMMVAMGLAGAKNYNELEHNALCNLMKAALHKWNQIKGKEPANPLKKALEKTLFGKDDGGKIEDLKGVLTQDYEKVQGKLPLRLQWCGLPKEGDTGENNQRWPGHSATHDLFCLCTTGQEGYPFNVVGSGNSPATKLCGQPKDALGGGSDGWDSKHRPGETEHGKDQMTATWSSVTQKCLVEDSNGKGLNEALAAFLGKLEKKKPEGKHTDRYQLGEGNADEYPCSGNIKICVMYYNTTRANYPMPWWTELQSALAAEENKSQPTPREHPQKKDEKKLQIWIPKTPPPQMPPPAALKSAPQTSQRQKKNPKISLIHSTLREQRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD4</accession>
    <name>F9WHD4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002415">
        <property type="protein sequence ID" value="CCD16726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14832" checksum="A137C02C5BBFD569" modified="2011-10-19" version="1">MLHNPQGLFRHTPPFTFCGESCRNHDVSLSRQPDSGSVTCHFQAHSNVRDFYFFMTRKLQFSLLQTRSHVLQPVALALVPAQAFHLGRWKERSEPMVVWERRSNSRSLTGEGQRSRAQSSPTSNVFVGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHF0</accession>
    <name>F9WHF0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_16460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002421">
        <property type="protein sequence ID" value="CCD16743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16460"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36556" checksum="DAEF9A8913B88DA2" modified="2011-10-19" version="1">MPDAVEAHHQLIRSLIVRYGCYEVKTVGDSFMIACRSPLAAVQLAGDLQRCFLHHDWRTTALDDSYREFEQQHTEEDVEYKPPTAHLDPCVYRELWNGLRVRVGIHTGLCDIRHDEVTKGYDYYGRTSNMAARTESVANGGQVLLTRAAYLALSTVEREHVSVTSLGAIALRGVPDPVEMYQLDAVPGRTFAALRLDREVPNVDGNDGESSTDVSTDTGSMSGGLRGSAKRYFKILCTVLGTFTTPQRQKLLLSLCERWRVTLPHTKKTEWDEEYCEEAVRRISAKVGRVVDHSGSNANGSSVSSLSSASVIIISNRLVEHEELSQDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHP6</accession>
    <name>F9WHP6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002470">
        <property type="protein sequence ID" value="CCD16840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17300"/>
    <dbReference type="OrthoDB" id="38414at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="643" mass="71534" checksum="054BF86B16A893EC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI66</accession>
    <name>F9WI66_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002532">
        <property type="protein sequence ID" value="CCD17011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18730"/>
    <dbReference type="OrthoDB" id="1690652at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="24860" checksum="608D3374FC73BD2F" modified="2011-10-19" version="1">MWNDGTQGACGCLFRVGREVSVSSPKVERAGLRRVRGLKKKHAFTGTLRLTLWRVERIHVTRKSASHVRSSRCGHTFNGMGLCRKPHRNAIRLVDGNTSNILLLGPPRSHNTAKMCHKPRGSLLTSYCFSLSCQGLYCLGRTHFNRIRRSCSVQYHTPAISEPLRASAPHHRLAAAHTSRGSNFHPPNCASQHNLRHTLAPRGQRPFCFASGCAATASGTKFTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI93</accession>
    <name>F9WI93_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_18970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002548">
        <property type="protein sequence ID" value="CCD17038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="704215at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="SSF101601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="297"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="466" mass="51530" checksum="EEDF2FC3329F16FE" modified="2011-10-19" version="1" fragment="single">MASAAGAGLGNHDVDRCVVGDVSCSATEVSAVESDIICTAPANLGSAKKKRTSENNGIHYVKVDETNASTTSSVATPPLLNEDEVLMNKIAVEYVLKPRRTTDVQPVRWETFNLVIPEDDAFDEFDVRLLRSPVYTDDDAEAKPPYQFVNGTPDLDGDIISCFDEPGILYRIIDRKQKIWAFYNDSISFEAHVSCTFSKYSKVEALENTVISRLPDGSTVAELVVYPTETEYFVKGLVNGFNSKMRALPLSDAYFTERRDAQHRSVVEGELKRIKDISGGKTDAAEVLSICVKEGTPFVDLEFPPVQASIIASTQVGALLLPWLRPSMYLSPLMIDQVRLFRKPIAPVDVQHSGLGNTWFMCAIAALSEIPVEVVRMFRHQDGAARARGERAVGAYRVTLNKNGLWRVVVVDDYFPYIAGALRFSRSSDPCEMWPAILEKAYAKLHGSYMRIRAGDPVHALTDMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE2</accession>
    <name>F9WIE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 775</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002575">
        <property type="protein sequence ID" value="CCD17089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19420"/>
    <dbReference type="OrthoDB" id="1676273at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="36653" checksum="57EAA1BE9E1B1E7D" modified="2011-10-19" version="1">MMCHGKKPFSSRIRTRTLHYMMCHGKKPFSSRIRTRTFHHMVSLGKKPSGGSGKKKPSGRIRTRTLHHMMCLGKKPFSSRIRTRTLHHMMCLGKKPFSSRIRTRTLHHMMCLGKKPFSSRIRTRTFHHMMCHGKKPFSSRIRTRTLHHMMCHGKKPFSSRIRTRTLHHMMCHGKKPFSSRIRTRTLHHMMCLGKKPFSSRIRTRTLHHMMSLGKKPFSSRIRTRTLHHMMCHGKKPFSSRIRTRTLHHMMCLGKKPFSSRIRTRTLHHMMCLGKKPFSSRIRTRTLHHMVMAKKVFTHPKGYRRLFSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIG4</accession>
    <name>F9WIG4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19630"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20151" checksum="CBE0548D78B11CEC" modified="2011-10-19" version="1">MSESPSSPSPEGMAQQDNPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPFIHSYVSRFSITDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIG7</accession>
    <name>F9WIG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19660"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="19060" checksum="C00533A9196E1DAD" modified="2011-10-19" version="1">MPESPSSPSPEGMAQETPWSMEKDVVDVLLEGVLPAKEMNLYGFLMPVSPHLTEFHTHFTLRDFVRTPRRFIEEEDWCDLIWQNLPRLVWKFKECVRPRLRHYGHPDGWKAAQWECWEILIHLDHPPLDVVGHQKYSTNRYRGTFFLYRPRRPSSTCRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ51</accession>
    <name>F9WJ51_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_21800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002684">
        <property type="protein sequence ID" value="CCD17354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21800"/>
    <dbReference type="OrthoDB" id="1669629at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="69"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="375" mass="42420" checksum="795998856758DA01" modified="2011-10-19" version="1">MFFSFLLWRRCVEKTFEVIMMICMLMIMVLLVGADTSGKNHNEHEHKALCGLLKVAVRDWEIVRKRAPSDPLRKALKRTIFGEHDYSEVESLKLPLLKDYEKVKSGFSARYRWCGERLSEKELPENRPPRWSGHSAPHDMVCLCTVGKGGWPLNKNEGSTLDRGNLCGHDKKALGAETNEGWGSTQDGLGKDQIEATWNKVVTPCLQLGNAQAGNLRDALQRFKEKINNKTEGNSENKYRLGDGDFDNYACSGNKNVCVMYYNGTSVTQKKHAKPWWIELEAAINNQAYAEKELKKSEEKPKNEGQNQHHTQKHEKTQPQQAPRTAALKSAPQHSKETEQDNTENISSPLATLEEASDTLIIPPCLWLLSALLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ60</accession>
    <name>F9WJ60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 875</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002686">
        <property type="protein sequence ID" value="CCD17363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21890"/>
    <dbReference type="OrthoDB" id="1725622at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="17526" checksum="0AC89F0F4961A413" modified="2011-10-19" version="1">MPRPREELLPAPRAGIRLLLAKQTLPTPGVSPATDRMISDPREASGPRQFASPGIDPSIPLGSTNHGSWITPNVSADRQQETPRIQRSTPARAGKYSTSFIHPRVPVLLHISSLVTVSLLPAPVLSNRRDTGVIPALGCLLDGVLDPGTTLRWPASPRGVRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ68</accession>
    <name>F9WJ68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002689">
        <property type="protein sequence ID" value="CCD17371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="13957" checksum="AD1F613F3A323927" modified="2011-10-19" version="1">MPSQEGCRIALDASGTASVTALYCKTLSMKLPSALVEESGVVALLRRAVYLALWRWITHSPPGLSGFTRGNSLVGTWVIQHGPKMLSHALLLIAPNVPLATLHATRIRLRVGTKEAGHSLYGAVASSTAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB0</accession>
    <name>F9WJB0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002704">
        <property type="protein sequence ID" value="CCD17414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22350"/>
    <dbReference type="OrthoDB" id="1677670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394821" evidence="5">
        <location>
            <begin position="19"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="38616" checksum="C8F4F4D9FE547875" modified="2011-10-19" version="1">MMTMMVWMVMMVVVGASGEADEKDHNGPQHKALCGLLKAAVTKWGNSGEGLSDPLRKALGKTLFGKWEGDIHVLKEKLPDDYKNVEKDTGTRSAWCGQPHHGGETNDQNLRRWSGHSAPHDMVCLCTVGEKGWPLNESESSSETETTLCGQNKQTLGAADGKGWDDDGEKELGENHVNATWFGVTVSCLQGETGGDLKKALGTFLGKLEHKPGDKANPNRYQLGEGKPSNWSACDGTSTLGVCVMYYNSTNPKKPQPWWVDLQKAIPEEEKFQEEKKKREEEERRKQQDSQKHNEPRTDDFTSTPTTANQTEKQHGGSNLTEKLRKFNITSGTLISLPSSWLLSAAFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJF0</accession>
    <name>F9WJF0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22730"/>
    <dbReference type="OrthoDB" id="1704424at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="22139" checksum="6F8562226A8E94E2" modified="2011-10-19" version="1">MPKRLAWSPEGDENDSWMSQRPQPKSGKEEAVSLPEDDEWMVWIRARRQEFRNPSWTMRTTIGEVLMEGMKDPRNLNLFHFLHLYYRDVPETVARFTVGDFLRDPERCIENGQWRRDIGMNLGRIRGRLSERLLHTSYDLFLCHIKTLEDWVRRGRKETVEAIARSLLDQALEQVQEAHTQEEKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK8</accession>
    <name>F9WJK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23300</name>
        <name evidence="2" type="ORF">TCIL3000_8_7350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002741">
        <property type="protein sequence ID" value="CCD17513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_7350"/>
    <dbReference type="OMA" id="PSHYRRT"/>
    <dbReference type="OrthoDB" id="939345at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="PTHR22504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC92506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28405" checksum="86F21D31A7E4B13A" modified="2011-10-19" version="1">MEFVPLESFEFLNSLLHSVEAQDCLMTVRLEAFTCRCTRKKKQLAASIADYANKTTPPLRPACPVGLPAPPLLNLSDEGPPTTQFEAVEHVEPSDIDDRLVFLVAALNSIYGEDGYDFSVLTEKDFVTCDEAHVRAEVNTTLRSLPPSCSPAVEQFWARVSEQTSDASQGCEYFRFSSPSCDPMASRALFSQHYFLYNKRTRLLVSLLVFAEGNLYRSDDGCAPDNHLYYDGYSSSSKSPLWPDGPGGASRDGECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJL7</accession>
    <name>F9WJL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 927</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002744">
        <property type="protein sequence ID" value="CCD17523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23370"/>
    <dbReference type="OrthoDB" id="1718627at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="18292" checksum="1B16CDE5A32497F1" modified="2011-10-19" version="1">MNMGGEREAVPNWTMESEVEQVLIQEYKTRDKINLFYFCVEYYGWTDGGFRHFTLGEFLKQPGRYLEDTNCREEVQKSIQHMLGCLHGNTVKDVRYFVGDGIITLCDWALRGASTLLDRVPRGTLDEAVREARKHPRSPTTSGSTSVQRRNEASDKLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR0</accession>
    <name>F9WJR0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 937</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002755">
        <property type="protein sequence ID" value="CCD17568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23790"/>
    <dbReference type="OMA" id="KWNITHR"/>
    <dbReference type="OrthoDB" id="1540258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="589" mass="64453" checksum="75254D4A76111896" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK27</accession>
    <name>F9WK27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002802">
        <property type="protein sequence ID" value="CCD17688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24740"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="447"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="575" mass="63381" checksum="403707436356DDBC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK80</accession>
    <name>F9WK80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_25250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002822">
        <property type="protein sequence ID" value="CCD17742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25250"/>
    <dbReference type="OMA" id="LMRRNGW"/>
    <dbReference type="OrthoDB" id="1163679at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="90"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="5">
        <location>
            <begin position="231"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="446" mass="49292" checksum="A8A6DEA2F339EC38" modified="2011-10-19" version="1">MFDNVMQSSNSFETKALPSAPLLAQGSAPCTHNRPIGRRHHHFTDDNVVDLRCVGGDVDRCVDAGFHRGGSPAGSSPTVSHCRPSHGVSPPTRILDFLFLGSVKDATNAEFLRRENIMTILNVSREEYWSVDSGITIHPFPVEDTAEEDIRKYFSYTYRLLEVARQAHYCFKLRNARVTNAIGTGATPCGSDSAEVGQRQRHDMGGAESNSSNTSAHDGAGACVENPVAAGKPPCVLVHCRYGCSRSPTIVLAYLMRRNGWPLEDALQYIVCRRPVVEPNVGFLNTLLSFQSTMEPEKRKIQRELLSLVVRNLPPNTSSSVVHKFFEDRVGCVQKVASFSPQATLSSSSLGADVKNSESNNNGERTDTMWLVVFAAPDCVQLVHHMYRRNPSFFEPLGMKQQVQVKLTPLSKLHRMLRSVEGSCRPPCKQQAQGDVMEQMEKEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W357</accession>
    <name>F9W357_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1002</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_25380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000354">
        <property type="protein sequence ID" value="CCD11565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25380"/>
    <dbReference type="OMA" id="WQYSSQG"/>
    <dbReference type="OrthoDB" id="1295967at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="PTHR12415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="548" mass="61842" checksum="52E436DD2FC37309" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3A5</accession>
    <name>F9W3A5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 102</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000381">
        <property type="protein sequence ID" value="CCD11614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02820"/>
    <dbReference type="OrthoDB" id="1724728at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17462" checksum="D950CCF1C4444B94" modified="2011-10-19" version="1">MLGVYFRTLLATVLMVAWRAACFRFHSQHMFAIYIYIFEGVYRLQSGRQLRGRCARHGGRLCWILPRPVPRVDSQHLKWMVESALVVVIIVKFSKTTVETFEALPMFSKLCCAGLVPLFLMVDVPYLLRPERLRTVATPITYRPVSVWGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3H5</accession>
    <name>F9W3H5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1053</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000411">
        <property type="protein sequence ID" value="CCD11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26480"/>
    <dbReference type="OrthoDB" id="1729790at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="18398" checksum="F05D9AC5373CFD27" modified="2011-10-19" version="1">MMENTQENNPTTNPLTMESTVEAILERARDDWGAMNAWNFFSIYYGNPYGMHRHTAVTMQQYLENPEKFVPDAAKREYIQFGLNLKRALMQRHLQRDLDRLKVANIVSLEDWKRLGATVDMGPMARMVLTRAFKQAMHHSPPKATLKKTPNEKEERGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3T1</accession>
    <name>F9W3T1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000463">
        <property type="protein sequence ID" value="CCD11804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27480"/>
    <dbReference type="OrthoDB" id="1683053at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="42232" checksum="5FDC65CD7351C8A1" modified="2011-10-19" version="1">MKEFGRIEKEQVAKPDVERLRRELETADRRRSDAQEHRRVRETKLETARLELANWNPEFERVTQASAEARQLQAWLLAVSQSEVVERELAKARGRQADCELRQILAEGLHHLAAATQGGDAAERELEEALEEWEEARDELKRTEEKLEWAIEAWVRAIQQWVEGPKEACEEAKENLEKAEEELERASEAWKATAIEKWMRANEKVRWSRRAWDRPWAEAREEWKGAEPRLYGARDLSGEESKEARANAKEKLEHVSELLKRANKKWHKEEWESIRRTAAEACQGVQTCEQALAVARQRRATSAQAFLQASRRRETLERLRHLWSRVPNESPSVGTAPSSSSDPPPETHSSHPTGQDRRNQPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3W2</accession>
    <name>F9W3W2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1119</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000484">
        <property type="protein sequence ID" value="CCD11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27800"/>
    <dbReference type="OrthoDB" id="1717063at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389852" evidence="1">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17749" checksum="760F9782AB2A9DC5" modified="2011-10-19" version="1">MMKIATLLLWWLGSGMRLGMDGLVTSASARNEAAKKLLYDVFTAAEGIREHANVTQKVKDAIYAAVYGAPGGVQFTDDGKFNHSHLFRRGKQYQRQKVCEYYNHHRGVDQTDGDFAENPFWGLCVFVCPAYHDMLYHLVWCVSQTPEKSMVGVPWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y5</accession>
    <name>F9W3Y5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000493">
        <property type="protein sequence ID" value="CCD11863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28030"/>
    <dbReference type="OMA" id="LIISEGW"/>
    <dbReference type="OrthoDB" id="1357038at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="40095" checksum="2A3533F2D297A5FB" modified="2011-10-19" version="1">MLCLTCRKVTFHSRRSALVNCLQVRQVGTANCGGKGHTAGAIAGTSVLERFNMKPEDIEKFLLQRLAHKFVEVSTGASPPRSVTSGEMGSILGKRLDGDITAGTKDDVRFHRRLSTRFTSQCDQEKVNGAMDVSFDTVHRDVRQRLSWAHEALSLLNTSISHCKIDSHKTASVPQRLVVLVLYSHTRHNAAVGFHMKRIRDIVNSMLAERHEDVLGVLNVVVGVRWRDVGPAEQIMGEAPRLTEQDGTERSDILWYPNAGMYTFNALLQCLADVSVCSGSQLQNGTCLRIHRKILIISEGWFHVRTAAQMHSCYNHKHCDVDTHHDTVHIEPMPFVLGSSHSEHELLQFARYTASRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z1</accession>
    <name>F9W3Z1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28080"/>
    <dbReference type="OrthoDB" id="1690216at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="244" mass="28230" checksum="A47D51F08C6A740D" modified="2011-10-19" version="1">MDQQGRSRGRRQAPGNYTGSTTSPNTIPWSMEKDVVEVLLKNIGDPKKINLYSFLQPAYPWIHSYVSRFSIRDFARNPWRCVGEADGREKYANSSPACHGSSGCWRSSWSIMRGRRRVGGHGNGRCGGSFSSWMRRTMILWRGWYGWCVACRHRSVKYWKRSTRLDTPGPFPCRIQRELNLCHLPKSVRLLHRHGVPWIRVSQLYFSSPITLPYSRRLITTEDGKGYLKFSEREEIDHGQYGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W491</accession>
    <name>F9W491_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000532">
        <property type="protein sequence ID" value="CCD11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="LRVYPWK"/>
    <dbReference type="OrthoDB" id="1493500at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="15212" checksum="DF3E67B4C07EFAE1" modified="2011-10-19" version="1">MFRAPAIALLQGGRTPRRTTHHAVSSARLGKDRFNLAESLRRERERVERNRALPWRDRLRQLQNYPWKFFIAFMVLWSWLGTYAVPYLKNMRPGELPALGDGRPIPAELKEHAKPMPRFRHLAPTSRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G8</accession>
    <name>F9W4G8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000552">
        <property type="protein sequence ID" value="CCD12060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29790"/>
    <dbReference type="OMA" id="TYLICDE"/>
    <dbReference type="OrthoDB" id="1341207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad51" evidence="1">
        <location>
            <begin position="65"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="230" mass="24391" checksum="1B67C04A2F16F81B" modified="2011-10-19" version="1">MKALSNSGLAALYIASGTVPASRLEPLARAALRRAKDMTLRAMSHLPSSEFEIVRAKLEQRVTVNSVISGVYIRCVRDIEELRQLLCDGTLSDSFSCFGSVGIVVVDSIAGTVSGGVLADGEVHGSAALVVGAVGALLKLFAIREGAAVLVTNQVRAVFPTTHQGAQRRQGLVPALGLQWAVAPHVRVNLRRVNNLSTAARRQLTIMSGPAHRPASGTYLICDEGIRNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H9</accession>
    <name>F9W4H9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1185</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000558">
        <property type="protein sequence ID" value="CCD12073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="RRTHREV"/>
    <dbReference type="OrthoDB" id="407203at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1278"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1356"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1705"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1808" mass="208724" checksum="0F98EAA03ECBF4AE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4L3</accession>
    <name>F9W4L3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000574">
        <property type="protein sequence ID" value="CCD12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30210"/>
    <dbReference type="OrthoDB" id="1698311at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23805" checksum="BB8B6A88429BE127" modified="2011-10-19" version="1">MVVYYNVQDGVSEIERMATQCRKGYAIFDEYKKEIFPYSFPPCWVALVMSTPSPERFEHWVNRYQAFPIYINCPGNLELKVVHAFGRFSELCQEVPLTEEMIEELKREWDELELRARKVGPLIRYVLDSHFHSRWEGVERVLKDSSRQCRRYSSGASRYSINREEHATLFKTTRYMMEGAEVGICESVSVTVHKKLNSVDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S1</accession>
    <name>F9W4S1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_30750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000597">
        <property type="protein sequence ID" value="CCD12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30750"/>
    <dbReference type="OMA" id="DIRPRQW"/>
    <dbReference type="OrthoDB" id="1015223at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="MRPL43/MRPL51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosome/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="PTHR21396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="L51_S25_CI-B8" evidence="6">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="260" mass="31427" checksum="27D8A8A9F08D74A1" modified="2011-10-19" version="1">MSRNGELCLKKVIISYCTSNGGPNTRQFLATHLPRFHARYPSVAIDIRPRMWPEATITGVYRDGSERSYNTKWLSPMGIFLRLNYLVNTGNDYDRPFSASHIHFQRRSVQGTWNPWLWNYEAARRRVEAPQWRRKLSEEEWDYYINQYSAQMKQEEEEIQQRVANHTSVQEQSTRDVQERWKQHVMPRMQTDVEFNLTQFKRQHAQGQKQRPVTMGEYRLFSVPDHRELGQDAVDMMRRRESQFMEEWWRKRKEQLKPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4T8</accession>
    <name>F9W4T8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1227</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000604">
        <property type="protein sequence ID" value="CCD12183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30920"/>
    <dbReference type="OMA" id="EREAMIC"/>
    <dbReference type="OrthoDB" id="1580213at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="280" mass="30759" checksum="B070FDEFC6F49CBE" modified="2011-10-19" version="1">MSASAPPEFLRCAADSYRSGHRMSAFSEVSSNSLPPDRNERSASVISRFRSLDRSVPLGRAFRQKVKSSQTTNISSCDASGFRRVSCGLTQGPSSTSSLVTRPSNQFYPEPLHPTALGRVSPTNSTSSSSSQRLTELWEMVQDLRAENAVLQQRVSILMEEGSEQYSEVLHGIPSHTSDHDDSNNSGNLLPCCNTATPDKAMNTANVSKVANDKNSRANSNDTGVNGSGHMTPYMIAEREAMICRIRRLEMALKLEAMERDALELRLRAQERVLARLALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4X3</accession>
    <name>F9W4X3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_31240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000626">
        <property type="protein sequence ID" value="CCD12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31240"/>
    <dbReference type="OMA" id="VCSVAPK"/>
    <dbReference type="OrthoDB" id="962471at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="442" mass="49718" checksum="6469AA4EA47899D5" modified="2011-10-19" version="1">MREIVCIQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDEATGGRYVPRSVLIDLEPGTMDSVRAGPYGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCCKEAESCDCLQGFQICHSLGGGTGSGMGTLLISKLREQYPDRIMMTFSIIPSPKVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFRTLKLTTPTFGDLNHLVSAVVSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMMGFAPLTSRGSQQYRGLSVPELTQQMFDAKNMMQAADPRHGRYLTASALFRGRMSTKEVDEQMLNVQNKNSSYFIEWIPNNIKSSVCDIPPKGLKMAVTFIGNNTCIQEMFRRVGEQFTLMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATIEEEGEFDEEEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z7</accession>
    <name>F9W4Z7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_31450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000636">
        <property type="protein sequence ID" value="CCD12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31450"/>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="5">
        <location>
            <begin position="36"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="208"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="504" mass="56206" checksum="2D37F5E66EA0F58A" modified="2011-10-19" version="1" fragment="single">MTGKDRNSGVGRRARASLEKNVPLNEASKLKANDQAIGKKTAYTIMRNFMNDDSKEELVFPSTLTKEERKTIHDVAEKFGLTHKSSGSSHRVLTVKKTQCSPEPESKKSLSAKQIMARTKGFQGLQRLPATRIESVVEVINDLTHPLVKRMIGEIKVFTGAAPKSYPLTMTRCGLRNIPRGTVTAERVKDLKEFRCALPSYKYKDVIVEYVRRSAVVVISGDTGCGKTTQIPQMLYDEEGLFDKNLQVICTQPRRISAISVAQRVAEERGEACGDSCGYIVRFDNNTSEKTRIIYMTTGILLRRLQTDPGLKGVSCVIVDEVHEREIETDLCLLLLRDLIMKGEKCHGNCMKLIVMSATVQPEKLVSYFSPEMIGSEVPVVMIPGTLYPVREYYLEDAHECLGLPPPSIPSSYEASRPPTVDGETNVCGGGTQTVYEEIMRNVGKESETKISFDLLLGLVRHFHRTSRDTSGSILIFLPGWSEISRLAKMIRKSELCKTYLVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W535</accession>
    <name>F9W535_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000651">
        <property type="protein sequence ID" value="CCD12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11593" checksum="08077234CD22B3EA" modified="2011-10-19" version="1">MAVFCFSQKTHLAPAECTAHRISKYQLTGPVRTLHAEAESRPGCEGRFRSDRRNVSGECQQRWCLLATRCWQPCWRVSPERRVSPAQRSGHWLAQVVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W551</accession>
    <name>F9W551_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000658">
        <property type="protein sequence ID" value="CCD12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16919" checksum="28AF9694F41BBF18" modified="2011-10-19" version="1">MIDEMALTPAGDVVRRILCIFVLGEFSNFSLYFFFFLKNVHFFSRLIGHQLVSMATPHVDCPYLRRKMRGRGKNSMATLALAPSVLRGTLSRLTATSVLCVGRKRMGGFGGVIRSRNGARQFCKDDRIAVKKSKKSRTYTERNNDLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I9</accession>
    <name>F9W5I9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1329</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000718">
        <property type="protein sequence ID" value="CCD12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33200"/>
    <dbReference type="OrthoDB" id="1714719at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16679" checksum="E8422EC003967C73" modified="2011-10-19" version="1">MQPGQQIICTDAGNNETHFQCISQHPNTHAPCRGQKPQCGQQLLHTFGLHHVPRVPGCAWCRAMVVTPACGNTRGNCTSAFYFIPSSCSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5U1</accession>
    <name>F9W5U1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1378</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_34160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000771">
        <property type="protein sequence ID" value="CCD12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34160"/>
    <dbReference type="OMA" id="NTEKFVD"/>
    <dbReference type="OrthoDB" id="1122174at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23236" checksum="BF6B0C5E08311CE3" modified="2011-10-19" version="1">MSETSKIDVRGVKSYKSVSNARKAYESDDIEMSRREHQKPLYNEGHSPAASDYVKSVVFGGLDGIITSFTVVSAAVGSSSGAASVLIFGFSNVLADGFSMGFGEYIAGEAERDNALSERRREEWEVENAFDMEVDEMVQIYEMKGLSHEDATTIVKIISKDPKLFVDFMMTEELGIIINMDDKHGPKKQGLVMFLSFIIFGTVPLWRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5W5</accession>
    <name>F9W5W5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1391</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000787">
        <property type="protein sequence ID" value="CCD12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34350"/>
    <dbReference type="OrthoDB" id="1728762at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="19976" checksum="E4ADE111737F0608" modified="2011-10-19" version="1">MARRGVRRTRDEMEEEAVAPVVRAEAAARGEVATGTVGAVRPVAMRNDAVARVSDTRTLDSLVKEELLEDCGGLDDMSPRDFLMTHFGRAVGYLTASMSDFIANPSFFLKDEALRTLVTDSEPYREYELYKTMREGADRLRAMGVIGLRRWESAVATNEVEGGDVHVKGKLNAALLSARHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X7</accession>
    <name>F9W5X7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000794">
        <property type="protein sequence ID" value="CCD12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16909" checksum="8BEF44FD8D597789" modified="2011-10-19" version="1">MHLVCPVVASWALTQKGLPFVEATGGEVRAGACGQAAAPRTDFPLPCHAHSEMFFTNKERGFCLLLVRSKTSSIETCDGVRVKQGLFFWIQICHSSSRYSDFPLQWQLHCAYALDCIRLSLTFIGIKHCLITFRWIVVMYSMREHLCKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W639</accession>
    <name>F9W639_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000820">
        <property type="protein sequence ID" value="CCD12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35030"/>
    <dbReference type="OrthoDB" id="1715850at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16760" checksum="1C8FAC6812E8C32A" modified="2011-10-19" version="1">MQPGQQIICTNAGNNESHFQCISQHPNTPAPCRGQKPQCGQQLLHAFGLHHVPRVLGCAWCRAVVVTPARGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCHTSHHTHVAATPHYSSSLQWLKYSTVACPGAINGSFTPPHIRSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W673</accession>
    <name>F9W673_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1429</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000829">
        <property type="protein sequence ID" value="CCD12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35370"/>
    <dbReference type="OMA" id="ATCYHGM"/>
    <dbReference type="OrthoDB" id="1006019at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="281" mass="30293" checksum="B6C3AE3C32439D47" modified="2011-10-19" version="1" fragment="single">MAAVTGVATPCNRSCFPIMSFLHVPGKMSQPLWLMMGTAFLVRVPGGAHLGGPTFNDSAYARNLNCGTRRVLLTAKHTFVPWQYTDPQKLKIPEEFRKTRFVIGRLYLPDDEGRAVGSRTVDLQLMALHPSLDISLVAVRPTSRPLQGLPGGCGHATVGGAWEAHAELERRAEAAGGGLELSVENPAEGSLCRIFGYRGTGLLGELDTFDPDLLQRVSSETREQLLESMNCVEGKQEGASTQVEVLSSEGMCRMVTGRCFHGMSGAPLLVDEKTCGGVLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6G5</accession>
    <name>F9W6G5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1463</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000866">
        <property type="protein sequence ID" value="CCD12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36230"/>
    <dbReference type="OrthoDB" id="1077673at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="27795" checksum="628D3C2BB10F2AF3" modified="2011-10-19" version="1" fragment="single">MSDASPSDMSAVELESNSRLQELSQFEEVRQDNLNFEYYERQFQEVLMNIENDEVLATFRNEYASLYHSFVKSHDGESRLLKKCLELQSDIDTCSTKLVSADELSRGDKNTIDTLRIEIEKTRKKTDVTKEREAALKDKVAAFKRELRDLEEKSHLQVEATAQKSAMQSLVRMQETVTKERELLGFQLASLQQDYSTVEKRLERVREAKESGDIELQKVRKAIEEKQAEADAHKALRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Q3</accession>
    <name>F9W6Q3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 1504</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_37010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000912">
        <property type="protein sequence ID" value="CCD12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37010"/>
    <dbReference type="OrthoDB" id="1716002at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="8">
        <location>
            <begin position="66"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19948" checksum="23A0A8CBE386A755" modified="2011-10-19" version="1">MSMFSIVSFHRCSRGVLNIYEALMSRWLHLQWIIACKTLILFNVGSKGFPGQDEAHREVPTKAGAAICTLSKTLKDVTPWATQQMKDGAAKITHLELKRVEWQSKFIQSNSKGSGYEECKITGLLFRRVRNEIDRVRAEVEKLGNEASKAAAFAANSARCLEEFITVFANAKGDDSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6V5</accession>
    <name>F9W6V5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Squalene synthase</fullName>
            <shortName evidence="5">SQS</shortName>
            <shortName evidence="5">SS</shortName>
            <ecNumber evidence="3 5">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_37460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + H(+) + NADH = 2 diphosphate + NAD(+) + squalene</text>
            <dbReference type="Rhea" id="RHEA:32299"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>2 (2E,6E)-farnesyl diphosphate + H(+) + NADPH = 2 diphosphate + NADP(+) + squalene</text>
            <dbReference type="Rhea" id="RHEA:32295"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3 5"/>
    <dbReference type="EMBL" id="CAEQ01000941">
        <property type="protein sequence ID" value="CCD12912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37460"/>
    <dbReference type="OMA" id="RDPLNDI"/>
    <dbReference type="OrthoDB" id="563702at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00751"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004310">
        <property type="term" value="F:farnesyl-diphosphate farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="PTHR11626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="452" mass="50703" checksum="CE740E346A89C323" modified="2011-10-19" version="1">MMDYFGEMYAMVRVRWQVRRLKSELRADDDDDLNFCYDILQDVSRSFALVIMQLRAGLRDAVCVFYLVLRALDTVEDDMKVPLDVKLRELPLFHTRLRDPKWRLDGVGTGRERELLQEFPRVSAAFTRLDSAFQDVIVDVCERMAAGMCDFLLRGSSSGGGSGNADVHGEIKCDERGDIAVESRKDYDLYCHYVAGLVGHGLTRLFVRSGLEKAGLEDDMARANHMGLLLQKTNIIRDFYEDICEEPPRVFWPREIWGRFTDDLHNFKGLPRLVNKPNGSNDAGDHDEVKQKALDCLNTMVADALEHLPHVIEYLSNLRDSTIFAFCAIPQVMAIATLSLVFDNGDVFHTKVKLTRGATCAIIYGSTELQSALRLARAYGRQVLHRTRPGAEGHEAVAQSVAAALATMDGVALQQKVAVQDGLTPRLLERYSALGGGLLLKIAESVFSIWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y5</accession>
    <name>F9W6Y5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1535</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_37630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000947">
        <property type="protein sequence ID" value="CCD12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37630"/>
    <dbReference type="OrthoDB" id="1678276at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="6"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="296" mass="32441" checksum="85191D52A9B95B62" modified="2011-10-19" version="1">MDNINKAAQLLKANAEGAARKAIASLKTAITTENDFENVGQEPQGWKTDTDRDTTCNSTENGGHAGVRLTTDLICLCIGMHYETHKACGTGIPGHDGGSWASPGNFSKEKKHWEDIDKDCNAMPLKDEFTIENINTSIENFNALLGANPGEWSTKTKRSSWVYGRTAGAPNCRTDGPKHWQKSICIDYGLSDGSLVEIKWRTQIYKARDLLLEVEANIAKARKLLERMEFLLVVLEKDLLLANISNSLVLATVLKTVRPHVSLKSFGGTEPQENGGGYNCFHLALVGLMALIFAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7E9</accession>
    <name>F9W7E9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001014">
        <property type="protein sequence ID" value="CCD13115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13748" checksum="9E19362A823FEF1F" modified="2011-10-19" version="1">MGLSLFILVSRTSAPPDETIQNTSRYLCRTVPPIPHTTDGGWASFLNGLTWLGGALRCVCHTTLAKGLQFLIAHVMPRSFHNTGSPSWVGLWFRIFLLSSGPLCSIVSRGDTVEENKLKEQDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W831</accession>
    <name>F9W831_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1696</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001126">
        <property type="protein sequence ID" value="CCD13357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41150"/>
    <dbReference type="OrthoDB" id="113231at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="561" mass="62144" checksum="5A493C6D9EBDE9B6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8C1</accession>
    <name>F9W8C1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1727</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001161">
        <property type="protein sequence ID" value="CCD13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42020"/>
    <dbReference type="OrthoDB" id="481670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="286" mass="30774" checksum="395FF8373FD07B60" modified="2011-10-19" version="1">MEKIGRGRGTGKLRAILKPKEQLFGGKYGSGGPVRGMGTEEKSVGAVKDFANKGSHQGITSADHALEGSTTSLQPRSKVSPESRRKRSILNPLRKKQLDHTAAEENEAPRPLRSKYLTQSKELSGARLATSDVSPAGDQGQQPAAFTTPMVHGPMQTLKGGGGKLSPTNSLIRKKLTQKRRKGSLPLTSVPDGSKVDFSSKGKERKTKKLPSECSSLNSSITCTANTVDCVAISGDDARQDDNGSQDDGRDPSLNESRDGQLTPYDEEDEEEAVHRYMENNKASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8E5</accession>
    <name>F9W8E5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42260"/>
    <dbReference type="OrthoDB" id="1723465at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="16684" checksum="76AE723FD10F18D1" modified="2011-10-19" version="1">MTLNCIEALAVRMKGRVGEAANLTADGVTESDQTATSFSHAAIGRVSVACSVGCPTRSDAGNAAFVVDKPQKPKLGATLGKRRVHAEHQKANRLKQTGETSCRAVAPLSEAALRGIKRRVVGYLPPCFTCARSFNGMRRSNTEVEQHLAGMTDATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W911</accession>
    <name>F9W911_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1811</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001253">
        <property type="protein sequence ID" value="CCD13700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44340"/>
    <dbReference type="OMA" id="VVYYGEQ"/>
    <dbReference type="OrthoDB" id="997982at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389979" evidence="1">
        <location>
            <begin position="28"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="29490" checksum="689FBC4FB989F4CC" modified="2011-10-19" version="1">MYIYLINVLSSLLLLLLFLLLLRACAAVMRGVVYYGEQFVEVPDASVTLKDICASFGIEGDLTGVCIKSRATGLIVVTLPFESLPEPCSDSGDMEDITYDLTTPDGGNDDDDDAGAKVSSTDDMTDILKQLVQLGAAPLLSAESNATIDPYDPRAAPGLLTRMIYPPSIYSPYRYCGDPLSSADRLGPSPATLLQQATPPYVSSVETYTVEKADESSLRQRPDLTPKTDEETNDIMQGLLTVASQARAIAALSNENRQVEVDVKPNIQSIALAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9C9</accession>
    <name>F9W9C9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_45250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001296">
        <property type="protein sequence ID" value="CCD13829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45250"/>
    <dbReference type="OMA" id="HARDNEN"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="853"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="898"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1122"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD13829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1181" mass="129573" checksum="367A114044C68EF8" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9H4</accession>
    <name>F9W9H4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable transcriptional regulator ycf27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">OmpR-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_45650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable promoter-specific protein mediating the interaction between DNA and RNA polymerase.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001309">
        <property type="protein sequence ID" value="CCD13874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45650"/>
    <dbReference type="OMA" id="IDRVWGS"/>
    <dbReference type="OrthoDB" id="1259552at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006291">
        <property type="entry name" value="PcoR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01387">
        <property type="entry name" value="cztR_silR_copR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="7">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="25431" checksum="E48B4B6EEB38719F" modified="2011-10-19" version="1">MKLLVAEDEPKIGMYLQQGLVEAGFTVDRVVTGTEALHHALNETYDLLILDVMMPGLDGWEVIQSVRIAGNSVPVLFLTARDGVDDRVKGLELGADDYLVKPFAFSELLARVRSLLRRGSAVPNQTSIKIGDLEVDLLKRRASRSGRRIDLTAKEFSLLELLMRRRGEVLPKSLIASQVWDMNFDSDTNVIEVAIRRLRAKIDDDFDTKLIQTTRGMGYMLDAPDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA11</accession>
    <name>F9WA11_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_47340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001371">
        <property type="protein sequence ID" value="CCD14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47340"/>
    <dbReference type="OMA" id="HTHRERI"/>
    <dbReference type="OrthoDB" id="64659at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032268">
        <property type="term" value="P:regulation of cellular protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388886" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="domain" description="RWD" evidence="4">
        <location>
            <begin position="57"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="301"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1266" mass="141034" checksum="415CC73187B1F73A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA56</accession>
    <name>F9WA56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001396">
        <property type="protein sequence ID" value="CCD14112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47760"/>
    <dbReference type="OrthoDB" id="1715143at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17731" checksum="B39D9AF66C7CAAC8" modified="2011-10-19" version="1">MQLLGKFLDNFLTFRILFDVVGWVFQENSEGHIGVASSVGCPLFLSYKVNEASVFPEFACLPEDLFQLIVPSPSWLTPCVWSAGCLMCELVTFLVSPLHGYASACYGRPRVLADFSDGFIQYKSWSPGQQCTRCTKSPIAESYDAIAHKVPDVFDRIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAB3</accession>
    <name>F9WAB3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001410">
        <property type="protein sequence ID" value="CCD14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05160"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="183"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="45605" checksum="3648800E4743C33D" modified="2011-10-19" version="1">MKPCSPLDPLREAAATIISWKPSVDRPGPSSRPPLSFGSLKSLLLTSLRVCVQVHCLVTGLIAYVVFLFLCSTHGAGDGVIVKKGMWFWMVMVVGVVTGTAAGKMVKSHNHHELADLCEVLGAAVILSNCGAAGARLRKALGQVIFWKHAGGNLENLQKVFPEEYGKECAEPTHWGSSYTTTLTTTPGKSIPHDLLCMCTVGSGGFPFYSGTDNTRTLCHKSAKELGCGMGSGSGCPNGHGWTETNSNNHASKHLKATWDSIVKTCLTKAPNTTLEHAQNSLEEHLNPKDGYSSVFWARGHTTCGGVNGDICVNYNKCDKASGRDFPQWWEALQDALPTANFDYTADMNTTGFSNTTFDEGEEEEEWQTQGASGKGIHHGPSSIRRHRKRSSHAVSHLFKEDGTPLTLPFLWPLGAFVSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD1</accession>
    <name>F9WAD1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_48400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001415">
        <property type="protein sequence ID" value="CCD14192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48400"/>
    <dbReference type="OMA" id="SWWDQRT"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="5">
        <location>
            <begin position="66"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="469" mass="50046" checksum="36BC13EB22B778BD" modified="2011-10-19" version="1">MSSAAPNPVPAGTEPVELTAVGCKGNDEQCHDTNPTPKPEDGRENVGCFAKVAAFMAIVMPPGGIAASAFNISASTLGAGIVGLPAAAQSSGLVMAMFYLLIITLLCIFTMHSLAVAAEKSNARTFEEITHKLLGRGASYFLAGIRAFHGFSGCVAYVISTGDILSAFLKDNNSDFLKSNSGNQLLTSVFWLCCMLPLVIPRHIDSLRYVSTFAVTFIVYLVIVITVHSCLNGLPENIKSVSVGKDESAEVVLFNSGNTAIEGLGVFVFAYVCQVVAVEVYMDMKDRSVRKFVIASTIAMFLCFTLYIMTVFFGYLDFGSSITGSILLMYDPMNEPEVLVGYIGMLVKLCASYALLGMACRNGIYSLIGWDADTVAFWKHCIAVVSLSVVMLLSGLFIPKINTVLGLAGSISGASLSFIFPALLIMYAGGFTWQKVGGFYFIVTYIVLLIGVFSLVFGTGAAIWGTING</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ1</accession>
    <name>F9WAJ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001441">
        <property type="protein sequence ID" value="CCD14258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16831" checksum="58A3A0F37DFA3395" modified="2011-10-19" version="1">MMDVGGDGKYEVERNNGVDEDEIGVWKEECNSETHLLLLLLLLICCVALLSIFSFSLRRQLTFPLSSHGDRWQIRDFHCFLFFELAPTPYLPPSFCRICVECLFCFILSTATPMVITTGMIEAAVTLNCYGERMLTLRPMSWEGNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT2</accession>
    <name>F9WAT2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_00570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00570"/>
    <dbReference type="OMA" id="QPPGCKV"/>
    <dbReference type="OrthoDB" id="143775at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:CIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097428">
        <property type="term" value="P:protein maturation by iron-sulfur cluster transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MET18/MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="PTHR12891"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19_N" evidence="4">
        <location>
            <begin position="41"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="949" mass="103764" checksum="8B167C0A55705891" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW2</accession>
    <name>F9WAW2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_50020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001489">
        <property type="protein sequence ID" value="CCD14384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50020"/>
    <dbReference type="OrthoDB" id="1671320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394645" evidence="8">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="375" mass="41106" checksum="AA5A5A37EA91A3FA" modified="2011-10-19" version="1">MKTLGIIFMLFMLCSSAAWEYPYPRKAVPTEAGESICGINKKLKDVAPWTQQKIAALRKTRDEYESKILDWNLHFHESPGCGGNESVLEEIHTALEAVNGEIKKLPAKAIQAGALAAKSAGRLDEFITVFANAKGGHNYCMGTGGKPAERRDLSECFSSGVDFEVGESNMATIPQHPSERGDTNLEAVIHRVNHSIMSAYFRRRYGEDAHADCNLIKGTDGGILVGKISEKLWWGGGILTIGSGFDGNISKLKGAKDKDSGEKTFWTASPHTIPHLKKTLAALQAFKDAAALISQKFSEIEKIEKQIEPCLSNETTEERPTQSCFKNAVKLNAELQAANALLARYHKEKGPLPSGSTLTLHQSVVQFLYLIAFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB67</accession>
    <name>F9WB67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2068</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001539">
        <property type="protein sequence ID" value="CCD14498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51070"/>
    <dbReference type="OrthoDB" id="1442450at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="248" mass="27098" checksum="B1818B45C676C2F6" modified="2011-10-19" version="1" fragment="single">MPGSCKVNAASTTDLWRGEQMMNKLLWATGAFLCVFLFICKAGRELNMKRRVLRAHANKRRMRLISAEHGLCLDGYNILCDASFLRAISTAICNHNLGRGCGDPSAVRSSPQRTLMSVMYQTFNAATSHTPQGAVAEGAEQPKLKGMTLSLYYLPETATTLRRVVRPGNGEKDAATQTGKCNGGMRASEKGDVSAVAEVLLKGLERVRYKNPDLTTDATQPRNEARAIAQFIADMKAGQISHYSIREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB69</accession>
    <name>F9WB69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001540">
        <property type="protein sequence ID" value="CCD14500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51090"/>
    <dbReference type="OrthoDB" id="1728743at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18128" checksum="234396651E499C7B" modified="2011-10-19" version="1">MQPCFFHIVVARLDLGSVSMFPPADYSCFSRSKPHSSLKFISIRRRTPFSQEDNQYLIESAGRNNINIHQKQQTERMKGRPGPQKPQVGGKGNSGGDGQRQKPQQPAGGAEAVNPDGGRRGDKEAPGTLDGLKSGVDRRTNLLFASAKLPKNILSAVKEVRSDVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBD1</accession>
    <name>F9WBD1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001564">
        <property type="protein sequence ID" value="CCD14563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16230" checksum="36F23A1BCD86E61F" modified="2011-10-19" version="1">MGNVSFSALGRVEELGARLRCGLDAVEGQIGERLFMEQGTFICQSLLDMVLINHSYFHRRIAKIFFQCAFTLRAPLDARLFPVLLKPAGNTDRNADTVLASFSKIVKQTACNGKAFFPSLWEATGTANDCAEGDGTSNKYGDRPLFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP8</accession>
    <name>F9WBP8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001607">
        <property type="protein sequence ID" value="CCD14681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52770"/>
    <dbReference type="OMA" id="VETTHKS"/>
    <dbReference type="OrthoDB" id="1663618at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="516" mass="58340" checksum="A343E148F1781587" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBV4</accession>
    <name>F9WBV4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_53330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001630">
        <property type="protein sequence ID" value="CCD14740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1659509at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="210"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="565" mass="63932" checksum="BB49EAD738BAE0C5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCB4</accession>
    <name>F9WCB4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001697">
        <property type="protein sequence ID" value="CCD14907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54770"/>
    <dbReference type="OrthoDB" id="1703571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="20593" checksum="00D6A5CC81F2BC6C" modified="2011-10-19" version="1">MGHGIISPKTYIPQTFETEKKGGVAREVHLWWVGPFLASVLLLSHQLSEFTETKMPIRKALSCHTVIWCRALVGPPGLSTDPLHSTAPSPVGLWHLSGSCGLRSHPPHTHWRLTTAGQTMARVAGNLHSPGGLLVTSLFSTAVLLSEDSLVGQEESQTYSLKLWSTPSFTIATSFTTSQLGSSLYKPHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCF3</accession>
    <name>F9WCF3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2224</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001713">
        <property type="protein sequence ID" value="CCD14946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55140"/>
    <dbReference type="OMA" id="LMIRNKN"/>
    <dbReference type="OrthoDB" id="1462113at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="24673" checksum="729324DE6DA8A715" modified="2011-10-19" version="1">MNSPSPQEAHNSSSNDTAMQLSEIQRKLNELKQRREELEQQRRQILGSISNTTSSDLPPPVPRRSEERNRSRYSQRMPPPPPTEHSIRIPSEKERKMSGPRNAHVEMKEAMRRSWSQDSMLVIGDFLLEDKPRTCTFGRERRFLPLRERPELYYLGTDMELMIRNKNVKPPTRGEIAKNPAYHWYTCACHGTPGPGAYTPRYSKVTKPTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP0</accession>
    <name>F9WCP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001745">
        <property type="protein sequence ID" value="CCD15035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56010"/>
    <dbReference type="OMA" id="YIPRRAK"/>
    <dbReference type="OrthoDB" id="1421292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="23002" checksum="DBCF30F9A3FBDFE4" modified="2011-10-19" version="1">MEEAMEAFPSPSELASAIVFSNVNTCECICTLISPCFFFVSYLCTARKKRQTIMSMFGAREIPDDTFSSDITNISASYLNENNCQRFWQRLMTCVRESQELDVLYDCRSRLINMRECVTRHKQSTWVFRETMATLRNEQKLRRWLKQYDEEFGHPPLLEAVAKVNERLKAEGGVDVLNPTVFRDPDIYIPRRTNAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS8</accession>
    <name>F9WCS8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2262</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001756">
        <property type="protein sequence ID" value="CCD15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56390"/>
    <dbReference type="OMA" id="TIEPCEC"/>
    <dbReference type="OrthoDB" id="1654475at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="821" mass="92194" checksum="316477ADD34D7AA9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD39</accession>
    <name>F9WD39_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001818">
        <property type="protein sequence ID" value="CCD15190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00690"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="20363" checksum="E6F9BFC19EA700AA" modified="2011-10-19" version="1" fragment="single">MARRGVRRTRDEMEEEAVAPVEQAEAAARDQVTAAVGPAISGDGLMQLMAMLTEMKQEMGAMKQEMNAMNNRMDAMNNRMDAMRQELKEEIKGVSEEVMKLEVRVEALANKGIKVVDGAYDAVYYAEWRLVVRSDEYGEGKLGMGVLDATSGKQPDLWCEKQADALYDPAEPWEGDVVPGVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDF1</accession>
    <name>F9WDF1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58350"/>
    <dbReference type="OrthoDB" id="1672432at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394897" evidence="5">
        <location>
            <begin position="29"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="303"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="40130" checksum="DF6997E725022D40" modified="2011-10-19" version="1">MFISDNKEGKVRMKVVLLLMMVIGICSSSGSEKNHNGAEHQALCDVLKVAVGKWEKRNDLSETLRKALKHTIFGSNGDEDLEGLRHALPKVYDDVLKQPGSRSFACGIVHNDKGAYGSINQVRWSGYSVPHDLVCLCTTGDGGWPLNDSSVATTLCGKKNELGGDSEREGWSGQQTGEKQMESTWKAVINECLKEDETGKSLQKAMDVFTKTFKLNHNGDEHGNRYLLGEDGSGSYPCGGKKQVCVMYYNETKTTQHKPWWVGLKNEINKEEYKKQQKKHEDEVKHKKERQNQHHLQEKDKSPNNVAPRTAALTSSNPEKQEAEQDNTKNISTPIATTEETSGTLLIQPCSWLLSALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDF2</accession>
    <name>F9WDF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_58360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58360"/>
    <dbReference type="OrthoDB" id="1674514at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390182" evidence="10">
        <location>
            <begin position="27"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="22"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD15305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44162" checksum="42C3736FA352DE77" modified="2011-10-19" version="1">MLVVMEMRLKWWWLVGVFMAWSQVLGTGNSPKAIPTKAGAAICTLSKTLKDVTPWVTQQVENGAEKISHLEMKLLDWQSKFIHSKSKGIGSEACKITGLLFRQVRKEIDKTRKEVKKLEKEASRAAAFAANSAGRLDEFITVFANARNDSGNGFCLGDRNAAKPEALRDCFIGKDFSEESLIDISERASEQEPNLFFAIDDIKHSALRSHFTTATGTTNAGCNLIKGASGGILGNTDLENSLWWGGGILTIGKGFQGEFNGSLVAGEIQAATKEGKHALWTADPAQHIVHLKNASDAFKAFKDVQEKIKEKVKSIEKKIQACMGGQESGENTTEQNATEPTTTTEQKTTSPTCFSNVAKIAAELKEKRALLARYQKVKGWIPPSSAFNAKYPFNHFGVLLTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDG1</accession>
    <name>F9WDG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001863">
        <property type="protein sequence ID" value="CCD15314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11103" checksum="97AC669D3A6FC66A" modified="2011-10-19" version="1">MCFEAVKSCWMRYPNLMPPLCCRGRNAQWTGAMRRRKGSLADNRVRKQSDHGLTFLRAGSVAHVHSTPAACVGITRVDCTIVSTPLAIHGVRVLLIVVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDG2</accession>
    <name>F9WDG2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001863">
        <property type="protein sequence ID" value="CCD15315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11167" checksum="BC4290866DFA6E3F" modified="2011-10-19" version="1">MDGSGRTGTLLVSLRTEYGPALWAWGARVLCGTPSVPQPTRHDITRIASLPLEGFRRAGTGVMLAPAVLFLTTCRLIRSGDFSSRKNHSRSLTFYRKFNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDT0</accession>
    <name>F9WDT0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Putative rRNA methyltransferase</fullName>
            <ecNumber evidence="6">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_06130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CAEQ01001910">
        <property type="protein sequence ID" value="CCD15434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06130"/>
    <dbReference type="OMA" id="LMWVFQQ"/>
    <dbReference type="OrthoDB" id="1362679at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FtsJ" evidence="8">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="10">
        <location>
            <begin position="237"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Spb1_C" evidence="9">
        <location>
            <begin position="726"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="632"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="865"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="644"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD15434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="904" mass="103078" checksum="5FF0118D9BD16FD1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDW5</accession>
    <name>F9WDW5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_59880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001922">
        <property type="protein sequence ID" value="CCD15470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59880"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="22652" checksum="2C7EFEA7386B1244" modified="2011-10-19" version="1">MAARTESIANGGQVLLTRAAYLALSTVEREHVSVTSLGAIALRGVPGPVKMYQLEAVPGRKFAALRVDLEVEECHALNESVCSRVSDQSELGPTERHINDTLGVLLGVFNLAQRQKLLKSLCERWGVPLPRKSPGVWDEAFGRRVRRMIALRVGRVADVGMRNSVDSNATRFVGFSPLARGAGDCPVDFEEGASAAECLDVRRSSLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE07</accession>
    <name>F9WE07_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001936">
        <property type="protein sequence ID" value="CCD15512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60180"/>
    <dbReference type="OrthoDB" id="1703757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="24212" checksum="794B55035A747A48" modified="2011-10-19" version="1">MTLSEVIPGFVKTTFSEVILGFVEITLFEVISGFVKITLFGVISGFVKITLFEVISGFVKMTLSEVISGFGKMTLSEVISGFVKITLSDVISGFVKMALSEVISGFVRMILSDVISGFVKMTLVEVISGFVRITLFEVLSGFVKMTLSEVISGYVKITLFEVISGFVKITLSEVISGFVKITLSAVIPGFVRITLSDVISGFVKMTLSEVILGGERGYVSSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE54</accession>
    <name>F9WE54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001955">
        <property type="protein sequence ID" value="CCD15560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06410"/>
    <dbReference type="OrthoDB" id="1661395at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="639" mass="69333" checksum="942ABF58AC779549" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE74</accession>
    <name>F9WE74_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_60660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F9WE74"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60660"/>
    <dbReference type="OrthoDB" id="1695528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="28802" checksum="ECB9168B476F3FE1" modified="2011-10-19" version="1">MACGYSPSFFLLLLFPPPFCGFRKKEHTLKIRKRERRLMRFLSGTACTFVILLLCGPGMGNAFFPWRRSFVCKEGEKLLQNLEDQFSQRLQIYAETLNSTESLRDHCESLQKVLATPPEMRSETGGKSYRAFLRDQTLLEEFRNQLKRLMQDIKNQCGSWIGFYLANWRLHQRLDQKVADGQRLRQAFDDHLSRVQALWDQANITGCSPEEYKRMVQAYQERQRERKQLRKAMDDDKESSQGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEA3</accession>
    <name>F9WEA3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001964">
        <property type="protein sequence ID" value="CCD15609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15618" checksum="B89EF2020D65CED2" modified="2011-10-19" version="1">MKMHGIARETVLKLTKVGREAFHEYDGDYDVFLPHVAPLPERGCWPFAPAVSRTSPYSSPMYTASKRNGEEEEGGNTDSVKLKRLWCCKRYASYGRLKRHVLAKHTYKRDSQKRTMSLTRPRILVRMKLTKMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK6</accession>
    <name>F9WEK6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 283</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002030">
        <property type="protein sequence ID" value="CCD15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07290"/>
    <dbReference type="OMA" id="YNTLEWA"/>
    <dbReference type="OrthoDB" id="101142at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="SSF81837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="2222"/>
            <end position="2527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2067"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2986" mass="329161" checksum="B905C8826519FBB3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEL5</accession>
    <name>F9WEL5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_07380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002033">
        <property type="protein sequence ID" value="CCD15726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07380"/>
    <dbReference type="OrthoDB" id="1666198at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390230" evidence="5">
        <location>
            <begin position="24"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="79"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="401" mass="43851" checksum="A802EA8C0FE8F873" modified="2011-10-19" version="1">MMKLFMVCLVVMGGLVRHWRVKAEASPTVSQDDNVKPFELLCKIYNVANHPPIKPVDTKEYQKMVDDINALSAAANGKERVNTQSEETKSAQTQLTGISRDAHRLLEEIKKVNPEGQAESARHAFNQVIFGEHGKEGDLYHGTLEAKQQRMAACGLKPLDKKGASAGKNLIVDFLCLCAQPNDFNEGVDEVCGVSVGSSDGAGWGGKLESPGTMWSEIKNGCGMFAKHGVTSTQDGYSIYHEFLAKVKAGGIVKVGSSSTVQQHGMLGTAVSDAGNNNFHCNGKKEVSTGRGTTTVGSGICIFYGNHHLEENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADSQQEEVDMEESPLTQHPNPDENENADSATQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ2</accession>
    <name>F9WEQ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 301</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002049">
        <property type="protein sequence ID" value="CCD15766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07780"/>
    <dbReference type="OrthoDB" id="1705050at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23120" checksum="B983E94A619E1DBD" modified="2011-10-19" version="1">MFVKLMMFTCINLMLMVGVLAIIVHSKGLDESNSNDFELPCEAIRVTTALWDTFAGLDYEPEEKVELGRKIEEIFFSSMSNVDGKGNWNLPERFGGDKPKRSEVCTSSSSTRETPSASESLASAIFRLCTSTNEDEDLCGLKVGGIGKCADEGVDVRVTFTNVWGDYYSNGVMNRCGGTDSSSMEGAKNNLSKAITKIESVLKKRHIRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ8</accession>
    <name>F9WEQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002052">
        <property type="protein sequence ID" value="CCD15774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07850"/>
    <dbReference type="OMA" id="EEFWAIV"/>
    <dbReference type="OrthoDB" id="1394271at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="PTHR11960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="SSF55418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="239" mass="26530" checksum="E87C215C8B800179" modified="2011-10-19" version="1">MADSTVRDMDATHASATGEKAATKERPMIIDRGIATHPLNRAWTLWYDSVSTYDCHQWELSLVQVMTVRTVEDFFAMLHYCKPPHVLRVSAQYHFFREGVKPMWEDPSNKAGGKLWVSLDEKALGERSGGEGSPRSRKESDGNSCNSLSGSGGKKPDLDIIWENVLIAMVGEYLDYGVEGEHIMGVVLSKRKYHNRIALWVKDASDKEALAAIEKQLVKEGGLPPTAKIIFTPHGSGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER2</accession>
    <name>F9WER2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002053">
        <property type="protein sequence ID" value="CCD15778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07890"/>
    <dbReference type="OrthoDB" id="1717451at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16534" checksum="23C54466ED7D3AF3" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTHAPCRGQKPQCGQQLLHAFGLHHVPRVLGCAWCRAVVVTLACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAHRNGERCGTSHHTHVAATPHYSSSLQWLKCSTVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER4</accession>
    <name>F9WER4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 306</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002055">
        <property type="protein sequence ID" value="CCD15780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07910"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17322" checksum="E23E37BB57F95E2A" modified="2011-10-19" version="1">MGVEQEVAPPCDGLSCAAIKDLHRGVTVSGLASFENEPISSHSNASKRQRSWDGSDEGPYAQLGTTGIDLRCEVGTGERGGVVGVKQSESQLESDRMKVNPSSVPCSQLALEARYPLDFAEFMSSMADEWNSDWMDEGDEELQRFLDSCTTVLVVPSTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF17</accession>
    <name>F9WF17_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 337</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002089">
        <property type="protein sequence ID" value="CCD15883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08770"/>
    <dbReference type="OrthoDB" id="333458at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="53"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="1">
        <location>
            <begin position="119"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="2">
        <location>
            <begin position="329"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="409" mass="46445" checksum="B3E0FE577040FFCC" modified="2011-10-19" version="1" fragment="single">MYVYDEYDQRIIEDRVKQFRDQTRRYLAGELSEEEFRPLRLQNGLYVQRFAPMLRVAVPYGQLTSRQTRMMAKIARDFDKGYAHISTRQNVQFNWPALEDVPDILAELATVQMHAIQTSGNCLRNVTTDQFAGVAADELIDPRPWCEIVRQWTTFHPEFAYLPRKFKIAINGSTSDRAAIEVHDIGLEPVYNAAGELGFRVLVGGGLGRTPVVGAFINEFLPWQDLLSYLDAILRVYNRYGRRDNKYKARIKILVKALTPEVLAQKVDAEMEHLRGGQTTLTEAEVHRVAKHFVDPEYKALSNQDAELAALDQQHPGFARWRTRNTLAHKKPGYVAVTLSLKPTGVAPGDITDKQLDAVADLAERYSFGQLRTSHEQNIILADVEQSQLFTLWGELREGGFATPNIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF43</accession>
    <name>F9WF43_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002103">
        <property type="protein sequence ID" value="CCD15911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="14926" checksum="B13D7C58F92269BA" modified="2011-10-19" version="1">MIYFSFYSNQSGKFKPFQYKTEPLMVSALFPFIAPAAICWCAFTLGCTFRYNVVGSFFPLTSNVFTGACFIHTDSPSNKLTNIQAAAANVARTAVNFRPIHKSPSISYAPTHNFQSSCAAKGGLSKPPTKGRGSQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFE9</accession>
    <name>F9WFE9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_09880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002137">
        <property type="protein sequence ID" value="CCD16017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09880"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390285" evidence="5">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="38250" checksum="1D9EA579BA91BFE2" modified="2011-10-19" version="1" fragment="single">MWMMVKIATWLLLWIGSGAWLGMDGPVLRISARNEVAGKLLCDAFQAAEDIRKHVNMSQEMRERMKMAVYGAPGATHFTEDGRLGVRNTFPSEVQYGRHTLCEYYSKNSPTKDVDGVFAQSLFGTFVCVCAPPITDRNAKLCGVRHWERRRAWSGYFNRGKIDKYLLQDVWLDVIKKCTAPVKNQESDLNRVARLARALEAVRNGVRLYRPNGEFLYILGEFNDIRGCSGRNANDICAAYHQRVGRWGIPWEQRLRHVLQELYARFEKPKETRAQESISWSNSAAPETYLPPLPPITEVLVDDEGQKVVVQDEDIPEDVENTTGAGLETENHTSVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFF2</accession>
    <name>F9WFF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002138">
        <property type="protein sequence ID" value="CCD16020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="121" mass="14126" checksum="B0ED3F7A88849615" modified="2011-10-19" version="1">MEAEKGRYFVCARCGSAYKRNGTRLSGTRAHATRKMKDESVVITLTMRHTLQCWHGPMKCEREQCLTTMHLQARHRQPRKEVEHNALKAMRQESAAYLLVCQTLFPLRQRHGLECLKEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG7</accession>
    <name>F9WFG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_10050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002142">
        <property type="protein sequence ID" value="CCD16037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10050"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394730" evidence="5">
        <location>
            <begin position="24"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="38380" checksum="B954CCEF661EA51E" modified="2011-10-19" version="1">MLKFWMVAIGGVVIGMLTEGTSSLTKENLNIKEHNALCEVLGAAVSLWDRVKDHNTPLKKALAQAIFGAENANGDIAGLIGKMPQEYNEDGDRHNWCGECSQGATIYPGISIPHDLLCMCTVGHSGAPFNVDQHHSLCGVEGEKWGCTTYKAPSHHVGEKKHWECSGKKWNTHWDKDRRQMAWEKVVKPCLDSLHRTNLRDALKSFRTKKSNNQIPNMDRHSNKCGGTHGDICVKYSGWCGKSGGSEFPQWLDALNDLTDADFNVIERTTAKRRTRRESSNDTTLSGTDEATFDNAEDPDTHSSQVRTTAHTQEATQSKIFSSFPKQESSTTITQTSSGLISAVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN9</accession>
    <name>F9WFN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 410</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002170">
        <property type="protein sequence ID" value="CCD16116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10730"/>
    <dbReference type="OMA" id="CARTRET"/>
    <dbReference type="OrthoDB" id="1656089at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="639" mass="72961" checksum="B3FCDE6FB2853704" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP7</accession>
    <name>F9WFP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 414</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_10750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsbD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002175">
        <property type="protein sequence ID" value="CCD16124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10750"/>
    <dbReference type="OrthoDB" id="26221at33682"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="291" mass="30238" checksum="3D6386D07C1C301F" modified="2011-10-19" version="1" fragment="single">MFLIAFLGGLLTVLSPCILPVVPFLFAGIDRTRSSILLTLGGMVLTFALISSLAVVSSEWVIQANNAGRHVALVVMALFALSLISARISGWLASPFVLLGNRLDPQTRKMSGPLGSLMIGVATGLLWAPCAGPILGVILTGAMLQGANAQTSLLLVAYGLGSALSLGTLIFAGRGLVNRLKASIPVTGWLRRATGFAVLAAALMISTGADKTLLAGASSESVSVLEKGVLQSVPKVVEYLVRKAKAEPTLALDNAQGPMPSLSGAVEWLNSPALTSESLRGKVVLVDFWTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU8</accession>
    <name>F9WFU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_11270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002187">
        <property type="protein sequence ID" value="CCD16178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11270"/>
    <dbReference type="OMA" id="DMKNTEL"/>
    <dbReference type="OrthoDB" id="1172839at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="SSF47095"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="201"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="266" mass="30765" checksum="0BFAA9EF8D64D155" modified="2011-10-19" version="1">MASELKSGPLPSDIEETVVNVMRQEGVRFITTKILRMHLEAKYQIEFTSHKKVIDEIVTRAMQRPEFRKQLDLALKEKDMADAIKRKRSGSAPQEDSKRSKKEAKVKKPEGYPKAARSSFILFAAEHRDKVKAANPEMKTTELFQELGRMWNDASEKVKEKYKNLADEDKARFDREVSEYKMQGGKEYSRSAKVKKDEGAPKRPMTSFMHFSKEFRNKNKGGGVVDVSRAAGAAWNELSQEDRKPYQDMAQRDKERYHREKKLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFW7</accession>
    <name>F9WFW7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calcium uniporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TCIL3000_0_11460</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL3000</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Mitochondrion inner membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002191">
        <property type="protein sequence ID" value="CCD16197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11460"/>
    <dbReference type="OMA" id="DWDIMEP"/>
    <dbReference type="OrthoDB" id="1076768at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="PTHR13462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="13" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="MCU" evidence="14">
        <location>
            <begin position="146"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD16197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37974" checksum="A5D6692253CA7478" modified="2011-10-19" version="1">MRLPTSASLFPSFIDTIQAREGIICFVVPHACEGGSGALEMITCFTRSLLLRTVTRGRACEGLAVRLGLRYASTVPCDQQHQLPDGDVRSPSVGLTAAEFSRTAPLLLLTQVLRRHAVVGRGAEGGESVITREVFDRYCRECHIEDSSRALELLCESATVVSISDGAAVHLRPAQFLQGQSYVTGARGLGEGSQLEVLLHEARCRLTEAEAEERELRLALQPAIQKAVGKRRLVWAAAFCFTAVQLATVSRLTFFDLDWDIMEPVSYFLGAGDTIILMFYLIRLGHVKKYSEYEEKMAAARVRRYAPTNFDWKKYEAAVKRVEEERHMVERMSKWFNQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG93</accession>
    <name>F9WG93_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002248">
        <property type="protein sequence ID" value="CCD16327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12660"/>
    <dbReference type="OrthoDB" id="1663545at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="47770" checksum="F79C4E8F21B0CCCE" modified="2011-10-19" version="1">MCFLRVIVMGWNEFFFYSVVSCSLVFLRKGLKGKMVMRKGARVLMVVIGMVMEDVWAGVYKAGTTFNEKEHHSLCAVFQASAELWEASEKSDKVPNEDLKAGLRHALFGNTNKNNLNGITDRLPKVYQRPGHRGWRCGSCQNDDPYFPGSSITHDLMCLCTPGYYGEPYYAWFGWSYWENGFTLCGKPRVDMIDNGYHGWYAYKSYRVFKGLNKPWKTAVWGCLKSRKSNAEHGSRNLTEKIDRLKVTMQNFTSTLKKVGGHDKLGGFEEHNEADGSDERHIHVRYGTCKYGRRPWWKKLKETLDGKKPEDLLVSRPTNEPARRPGENPEDDLGEELSEEMEENEEDTEAEGHNITEDTAAQDANGTHTQGLTDSTDSTVLPHDTEETESSTYPQFQYLRSNTPKTLPCSWPLGVSFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB0</accession>
    <name>F9WGB0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002250">
        <property type="protein sequence ID" value="CCD16344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12830"/>
    <dbReference type="OrthoDB" id="1699496at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="21720" checksum="3F2D1888E42E4360" modified="2011-10-19" version="1">MYFPLRVERINPDVAQGEPCVVAVWCSANRTVLLTSEMEWLSCGLPISRSPCGMSGQWQRMDRYGALGRWIKHCGEAYTFGKMQWSNKVKAAVESLALSPTEESSLDAVLNSIHLFCSNHIVALLVPGNRENCKSLLFVQGEKPNVQIVHNGERTPIAAIAGADKLLQDCTVDDDSYVYPLSKGHAIVACDHFVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGM6</accession>
    <name>F9WGM6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002292">
        <property type="protein sequence ID" value="CCD16463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13830"/>
    <dbReference type="OrthoDB" id="1713079at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18603" checksum="3B1D6FE493407289" modified="2011-10-19" version="1">MSVQRSNEEGDKLTHQVASNPSTPRQPGGTEDSELEGILRKAFKSWEGACLVDFLTQECGKTQGACNPNVALAAFLEDPFHYIEEDERRKEAVEKLPEKLHHLKGCIIHDVPFLRAIGITTREQWAYRRFYHKMLTPIANYILLRACGSPLDGGTNKEDTQTVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGR2</accession>
    <name>F9WGR2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_14180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002306">
        <property type="protein sequence ID" value="CCD16499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14180"/>
    <dbReference type="OrthoDB" id="1594208at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="SSF47113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="18997" checksum="3241FA487D4C60C3" modified="2011-10-19" version="1">MFGRARKNVFLRDLVYVCVACDHVHSASVIASACVDVLPSLHPRLPLPLLVLAAHSVYQTTSYKLSSFKCIMAKGKKSGEAKGSQKRQKKILRENVRGITRGSIRRLARRGGVKRISGVIYDEVRSVLKSFVEGVVRDATAYTEYSRKKTVTAVDVVNALRKRGKILYGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGX5</accession>
    <name>F9WGX5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Electron transfer flavoprotein subunit alpha</fullName>
            <shortName evidence="2">Alpha-ETF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_14770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002345">
        <property type="protein sequence ID" value="CCD16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14770"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1128607at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="12"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="34152" checksum="AEC9ED2C365534F6" modified="2011-10-19" version="1">MLVRSSTLLGKVLLLAEVHRGAIFPGTLAAVTAARQIGEVSALVAGTNIESIAEKMSAVKGVSCVLTATGSQYDHGLPEEYAPLVESLVKSEGFTHVLAATSAFGKGVIPRTAALFDAMPISEVTEVRDESRFVRHMYAGSIVSIVRSSDTVKFVTVRGSSFQRAELSGGIGAQREVVATPSVGISRWVEDLAVKNDKPDLQTARTVVVGGRGIKSGENFKLLHDLAEPLRAAVGATRAVVDAGYCSNDMQIGQTGKTVAPDLYIGCGVSGAIQHVAGMKNAKVIAVINNDPEAPFFQVADYGLVEDLFVAVPKLTEILRDSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI4</accession>
    <name>F9WHI4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 653</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002440">
        <property type="protein sequence ID" value="CCD16777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16780"/>
    <dbReference type="OrthoDB" id="1698205at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="24734" checksum="5C938D40B4E46A43" modified="2011-10-19" version="1">MLIPLACLNQVPSVCLFPLIRHFLLMSHKHPATLTNMYAAPIHMHKHKKALFVHEGHPPRHFFLFFKHVTVPLLPHQRTPPVALRNFAPALWANNSRRGPRPPLPPCRPPAADLPVRCDAWKRQRVLVRTLGRRELTASASCRWAAGPPPCWRMRATVALCWTWQRAYTALRYFAPCWHWASPSKSRSLGMKCAWKALPRCTVSDRKTWRCSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ6</accession>
    <name>F9WHJ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 658</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_16890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002446">
        <property type="protein sequence ID" value="CCD16789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16890"/>
    <dbReference type="OMA" id="PMFTEAY"/>
    <dbReference type="OrthoDB" id="492611at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="161"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="679" mass="76333" checksum="32DF67BF251846CD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHL7</accession>
    <name>F9WHL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_17090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002454">
        <property type="protein sequence ID" value="CCD16810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17090"/>
    <dbReference type="OMA" id="INKPRSC"/>
    <dbReference type="OrthoDB" id="296827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390398" evidence="2">
        <location>
            <begin position="27"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="711" mass="76791" checksum="90DF07B2246C13FC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI04</accession>
    <name>F9WI04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 715</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_18290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002509">
        <property type="protein sequence ID" value="CCD16949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18290"/>
    <dbReference type="OMA" id="TREVCIL"/>
    <dbReference type="OrthoDB" id="693214at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="35628" checksum="1A589B1F3C31435D" modified="2011-10-19" version="1">MHLLGKGGFSEVWKAFDLKEARYVACKIHHVQREWSPQVQQHYRSRVVRELSIMRKVEHPHLTRLYDVFEHGPTTFVAVMEYSGGMDLDTRLKRYGTLREADARLIVLQIVSALRYFAAQEQPIIHYDLKPANILFHCNNSTSVEIKITDFGLSKILPKRGGPNDDPTIELTSQGAGTYWYLPPECFETTATPRISNKVDVWSCGVIFYQMLFGRRPFAEGESQGQIWQNKLIISSARTLRFPDTPRVSQEAKDLIQKCLEYSPADRYDVVQLSQDAYLQRNTRRYTRTTERIVPPAAPRPETLPQPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI42</accession>
    <name>F9WI42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 729</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002525">
        <property type="protein sequence ID" value="CCD16987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18560"/>
    <dbReference type="OrthoDB" id="962804at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="277" mass="31559" checksum="2C95AC52C60B7BCC" modified="2011-10-19" version="1">MNGPFSDGTEQNVATPSHLQRPQAFEKSNVRTQQMLSPCSQCMKAKDVLCEPRAVVRGKRNVPSRDGKTTRGCRTRSREKSVISPTRAPPRRSPSVRRIRKVCEDWVVQLREDAEAVQQALQTVVILLSTQRQVLNAKECNGASQLHTFRRERQQCTQIIKNSGMLQDTEVPVEAVEFFAFTPEELNCVRADDSTLQDARDTMGMIADVNDTLAGKRREALNCIRLIGDAKTCLRYIVLLIEEENDRSLYKYVDEVTEFMTCEKEKLDRIEAMYTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI70</accession>
    <name>F9WI70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 737</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002534">
        <property type="protein sequence ID" value="CCD17015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18770"/>
    <dbReference type="OMA" id="SSANQCA"/>
    <dbReference type="OrthoDB" id="539729at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="PTHR15237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="502" mass="54078" checksum="3B740A8F84FC3D45" modified="2011-10-19" version="1" fragment="single">MFLTFTIMGDFLRPFLQLLQTTARQGEVIYFEPLEGVLRLRSVSASRTVYLLATVATEHMNGYRYSGKSSAAAGVTLDGVDEARGETSRGGADVECHLPILGKALLSTVLRQGQQLRSLSVHYTDEDCDVGTGDTMRWECIVGDGTVKTFLLQLLDKMPERILISPDAYTFDACAPAKIWGSFLRHLPSSPYVIIQPRRQHLELLVINFSKGAEQEPDSTIVVWPSDLLFMHQKSTANSSIDSDVPLPGKVIDAKPFKQVCMLADQLGMMIRVRSGVEKLPLFVETITAQEVGEVAAGRASAFLSDGPEGSLSDGPVSRLMPLFSPFRVRFSMYISANDIALPEVFGPNNLATASRRSTNSSLTGPRDSSSFVGVCPSPRSTAIATSKPSHGDPKASARSRLPQAAIDHPVAATPVTTIGERVVDSGFNSVAVSPPLRPATLCESTPQEGSEEQVLPSSSHVRDSEARFDVNMGVEQEVAPPCDGLSCAVIKDLHRGVTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC2</accession>
    <name>F9WIC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 76</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002565">
        <property type="protein sequence ID" value="CCD17068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02150"/>
    <dbReference type="OrthoDB" id="1662462at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="50391" checksum="AF9AE6FAC163B6AD" modified="2011-10-19" version="1">MSDTVHISDIAHIGDTVQLSDTVHISDIAHIGDTVQMSDTVHVSDIAHIGDTVQMSDTVHISDIAHIGDTVQLSDTVHISDLAHIGDTVQLSDTVHISDIVHIGDTVQLSDTVHISDIVHIGDTVQMSDTVHISDIVHIGDTVQMSDTVHVSDIAHIGDTVQMSDIVHIGDTVQLSDTVHISDIAHIGDTVQLSDTVHISDIAHIGDTVQMSDIVHIGDTVQLSDTVHISDIAHIGDTVQLSDTVHISDIARIGDTVQLSDTVQLSDTVHVSDIAHIGDTVQMSDTVHISDIVHIGDTVQMSDTVHISDIVHIGDTVQMSDIVHISDLAHIGDTVQLSDTVHVSDIAHIGDTVQMSDTVHISDIVHIGDTVQMSDTVHISDIVHIGDTVQMSDTVHISDIVHIGDTVQMSDTVHISDIVHIGDTVQMSDTVHVSDIAHIGDTVQMSDTVQMSDIAHIGDTVRTDDIFHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF7</accession>
    <name>F9WIF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19560"/>
    <dbReference type="OrthoDB" id="1664488at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="519" mass="59418" checksum="9EF15036AC140023" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIH9</accession>
    <name>F9WIH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 794</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002596">
        <property type="protein sequence ID" value="CCD17126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19750"/>
    <dbReference type="OrthoDB" id="269827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="Iml2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="PTHR31859"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="262" mass="28990" checksum="F72DDE9B5B0AB783" modified="2011-10-19" version="1">MLFGFAQACCYDMLALEAAGSGDGEAETRHRRESAEAMWRAAHYKSRVIGGKKIPAEEFVEARLKEVFHHFGVRYPKEKTFDTFESAPLPAEGGASLRNLVSIGILELLAAFNLMHRVPQGDLEKHLATVEETLKNSSEASGDSSPKSKKKKMAVGYTAVVPRAIKANMLCRIGTRREEAKALLESTLEVSHKYKGSHCSLSWIVPHMLYEKAILAATEGDKEAMKSLLKKAREHIAGTVLLNAMDVRLHLTDYGMEVPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK4</accession>
    <name>F9WIK4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002610">
        <property type="protein sequence ID" value="CCD17152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19970"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389175" evidence="5">
        <location>
            <begin position="18"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="88"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="30735" checksum="BB6D2A4BDB112567" modified="2011-10-19" version="1">MMKFFFIVIVVFVSVMGNDHYNKKEFEHLCKILKVAEGEPQKIPDELRNITETRHILQRLLRATKTSSSTYQKVVQLKSDDKEDTEFISYTVKRRIANEKIQHAMEKVKDIYSRMEEELIQATNERTLARNNLVHAIYGVQVGELPQDKEITDVLKNISRSSISNDNGGEKKVKYHEAKMEKPCGGAGESGAGFTLINDFYCLCVGKENAKAVCHEKIRGPCCCCCGVKCQDCKCEKNCDDCKCKNCDGCEDCKLHNKWLSLFDVIKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ2</accession>
    <name>F9WIZ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 854</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_21230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002663">
        <property type="protein sequence ID" value="CCD17293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21230"/>
    <dbReference type="OrthoDB" id="255547at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="34710" checksum="69736988BDC2008F" modified="2011-10-19" version="1">MTPARMMRDREDLLMRVHQLEEQLNDICSSKTKEVEVVLLRDELAAAQEEVSKLRAERDELQQRVRRYDTYYRSSPAEACAEEFGQEAGCAWDVATATDAMTVVALEQQLRLAHARIRQLEPDSVGLVSDDGTHCTSVSGSRNESPESVNGLSSRPTTFTTTSLLRSTSNVGNAVVLQRRIDDMQKDLDERQRALNEAEERLNAEIHANKEAGERLRLLQAELHSVWQRLEKSEYQLKVVMEDSCCYYCRGTFGSVGSKQPQRDVVAGEETERLRMELLEQKRRVKEERKRRQRGEESSCGDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ4</accession>
    <name>F9WIZ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_02370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002665">
        <property type="protein sequence ID" value="CCD17295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02370"/>
    <dbReference type="OMA" id="VARDCND"/>
    <dbReference type="OrthoDB" id="1710678at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395092" evidence="2">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="453" mass="48734" checksum="C06F2E76468F1849" modified="2011-10-19" version="1">MAIRFPYYLALLFYVTGIPSVADPNDDENEKLTVEAVQSVCELTKIMRGVGESTKELQSQAEAHASEASKAKEESESAVGRAEEANEKSPEAADALERAREALSEAEEASEEAALASKEAEKHAENATSLATGQQEDLEKFLREIAEDIESDEDIKAVARDCNDTNSSVTSEGLDSARRNAKKHFTSEAANTLENITNATVEVFSNLEKEVQRAKESQDTAEKARDAATEAADDAEEKAKKGGGNTSDDDDNSSDEKEESPGKDEEKSPGEDEEKSPGEDEEESPGEDEEKSPGEDEEESPGKDEEKSPGKDEEESPGKDEEKSPGEDEEESPGKDEEKSPGKDEEESPGKDEEKSPGEDEEESPGKEEEKSPGKDEEESPGKDEEKSPGGDEEKSPGGDEEKSPGKGEGKTPGKDEESSDEDEYEAVGSARFRGTGVGLFLSLALLVHATVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ13</accession>
    <name>F9WJ13_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_21420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002670">
        <property type="protein sequence ID" value="CCD17314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21420"/>
    <dbReference type="OrthoDB" id="1665820at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395094" evidence="5">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43405" checksum="21EF4C88ED5CA09B" modified="2011-10-19" version="1">MMKLFMVMMVVMGGWVREGRVKAQAGPTVSQDENREPYELLCKIYNVAQHPPIKPVDTKEYQKMVDDIDALNAAANGKEGVNTQSEEAKSAQTQLTGITRDARKLLDGIKKVNPEGEVEKVKNTFNNVIFGEHGKEGYLSHGALEVRDIRSKACGSNSQGKGTSAGKNLVVDFFCLCAKPNLGDEGVDNVCGVSVGSGDGAGWGTSLQSITTMWGEIKQGCENVATAGTTSTQDGYSLYHKFLDKVTAGGKIKVGSSENDRKPGMLGTAVSKTGNTNFNCNGQKTVHSRFSYPSGICIFYGTHHLEQNIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNKARELYEKVKTDTQLENEDTDDSPLAQHPNPDENENADSATRSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ17</accession>
    <name>F9WJ17_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_21460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002671">
        <property type="protein sequence ID" value="CCD17318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21460"/>
    <dbReference type="OrthoDB" id="1676016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390459" evidence="5">
        <location>
            <begin position="18"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="333" mass="36788" checksum="9F2B816AF6077A86" modified="2011-10-19" version="1">MKLKCLIVVVMCLVVRAEEEEKKDHNGPQHKALCHLMKAAVGKWGTSGEGLSDPLKKALGRTIFGSESGGTLEALKDLPSDYTERGAIRGNFCGQPYEDPTFYSAPHRWSGYSAPHNLVCLCTKGENGWPVNSSDNQDTLCGKTRDALGGGNKGWTGNNTGQAEMEATWKEVVTHCLKGETGGDLKGALSTFLGKLEHKPETANPNRYQLGEGKPTDWSACDGTSTLGVCVMYYNSTNPTKPQPWWVDLERAIPEDEKFQKQREEEQRRNQQQEAAKKDTNKTEDLKSGPQTKNQTKESRNDNLTEKVRKLNLASGTLITQPSSWLLSVVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJJ1</accession>
    <name>F9WJJ1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002733">
        <property type="protein sequence ID" value="CCD17496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543832at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="49"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16355" checksum="1954806DA69634D2" modified="2011-10-19" version="1">MPFIRTGLATLRRSVEVHKKIPQSVFNDVARNIDEVLNPNLKDYEGSRVTPHHGAVQRHTADRGWKDCELSLDDNGIVMRDVETGTTEKVELGALTSVCPIDASMAREKYVFAVKNHTGKAYWFKDVDEAAYKRWITVLQNAVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK5</accession>
    <name>F9WJK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TCIL3000_11_8580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23270</name>
        <name evidence="2" type="ORF">TCIL3000_11_8580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002740">
        <property type="protein sequence ID" value="CCD17510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.8580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23270"/>
    <dbReference type="OrthoDB" id="1557011at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028045">
        <property type="entry name" value="HROB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15072">
        <property type="entry name" value="HROB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC95404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="201" mass="20751" checksum="7010D14AF2F122C8" modified="2011-10-19" version="1">MDFETLLQQAASERGLTMTPLSSVAGMSSSQKLACCGGLVEKIVAESERDSTVILRDATGSLHCALHGVVSGRYPDVLMTGALLLLQNVTVMIVPPLMPPILVVCLENLVALLLPDGPPAGAGDCVDAAMSTEASLTSSHQLSAARILPQLGVSEGPTESFPELSTGASASHTAVGTEVVVNRVSPDQDSDKDSLQLADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK16</accession>
    <name>F9WK16_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2301</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02710</name>
        <name evidence="2" type="ORF">TCIL3000_0_57090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001798">
        <property type="protein sequence ID" value="CCD15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02710"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57090"/>
    <dbReference type="OMA" id="IIVIERR"/>
    <dbReference type="OrthoDB" id="1709086at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="25956" checksum="072517D813FBFAA4" modified="2011-10-19" version="1">MLDLTTKSAMYILLGMIFFVSAILAIVICIEKRRIAAAMQRRRRLQEEADRNATGEQLLRRLMRQAIQMLLTHKVVNEGIPLASSFGVLEVMADRELRSNRNRGRPPRLTMADGTRDTITGVVRRARAAGPLPDSPPGPALMELLEALRERQQREAATQPFSESDRTPLEELIDGLVKAEEEVRSAEIEKEMETFSDPNQAYGVAAPYTPNPANKCIRYVMSSGKNNASAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK30</accession>
    <name>F9WK30_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 982</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_24770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD17691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24770"/>
    <dbReference type="OMA" id="DRMALQC"/>
    <dbReference type="OrthoDB" id="1492at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
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    </dbReference>
    <dbReference type="Pfam" id="PF03028">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="412"/>
        </location>
    </feature>
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        <location>
            <begin position="565"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Dynein_C" evidence="6">
        <location>
            <begin position="709"/>
            <end position="1001"/>
        </location>
    </feature>
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            <begin position="434"/>
            <end position="508"/>
        </location>
    </feature>
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        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12781"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1005" mass="114137" checksum="3AFE30F486E81B2D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
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    </gene>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002823">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395131" evidence="4">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="503"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="581" mass="65898" checksum="747049EFDD91DC22" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3B0</accession>
    <name>F9W3B0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1028</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000383">
        <property type="protein sequence ID" value="CCD11619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25880"/>
    <dbReference type="OrthoDB" id="1701330at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="21504" checksum="C7FE352E3DD29D74" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMSFLVFHHPARCKTVFATIISCFIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMSFLVFHHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3E8</accession>
    <name>F9W3E8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1043</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000399">
        <property type="protein sequence ID" value="CCD11659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26240"/>
    <dbReference type="OrthoDB" id="733786at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="296" mass="32519" checksum="C91797F417DA7BF2" modified="2011-10-19" version="1">MTYAISPVMENLDGLRVVLTWGKAPRDLDSHMIFPGNNIFFNNKKGTDAELDVDDTDSFGPETITLQKKHYGESYVYAVHDYSNSGSPTSSELSNSEAKVFVYMGQSLVRTYYVPQNRTGNLWTVFRMTGSGDFQDINTFTGVRVGAEDVLNEVKPLLDDSVAVTAVTVSSSVQADAKKLNLKGEAAYQAGNLDQAIDFFRQAIELDNSFGKAYGNLGLAYQKAGNTAESIWANRKAIALATGTNAATVRAGAYYNIARIYEAAGQFPDALRHYQLAKEQKANPVYDTAIERVQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3K7</accession>
    <name>F9W3K7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_26790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000430">
        <property type="protein sequence ID" value="CCD11726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26790"/>
    <dbReference type="OrthoDB" id="1667705at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39937" checksum="03C097199961B30F" modified="2011-10-19" version="1">MVYVLTYLFALSFYFRLGCWMVMMEHVIMICFMGVMVMRATHSETDHNEEAHKLLCSVLGAAVAKYNEVKDEESRELKIALGKTIFGNSGGSGRIHSNLPMPENYNTEGDGKSKNNRKYLCGACDGETHPGISATHDLVCLCTPGQMGWPISSTKQNEKLCGKNQSTWVDVGSVEKGWYTGWNIEEKDSGRDHIKKTWVGIVNECLKGGDASNLEKALKTFVTKVRGIGEDPLGKGKSDCDGKLGFAACVLYHPRCAKNRWWEELENSIQKDKEKAEREKSKAVEEGEKLKTYNEAQATPQIKARTPQPTPRVSQSPQNGETHDLPIEEKLIANITATHNEDGSPLTMPQWLILAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y3</accession>
    <name>F9W3Y3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000492">
        <property type="protein sequence ID" value="CCD11861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14349" checksum="772A3619F8D80D1E" modified="2011-10-19" version="1">MKVCEAQYAEAADKVFSPQHAIYSKLEKVRHTYNTIEVAVKPHEATVLQWAKEVYFNTTAPGVLKAETPKEERKVHTMRRVQRFNGYDYQAWKDGPVALDVSSGAEALVCPRTGKKVRRSPWVVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W469</accession>
    <name>F9W469_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000522">
        <property type="protein sequence ID" value="CCD11957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28910"/>
    <dbReference type="OrthoDB" id="196567at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45036" checksum="1C70997BECE12F84" modified="2011-10-19" version="1">MRGECERLHKIASQGMQPQTPLDFTKVKSSFMPNPPSRTDVDELMKKNAILQALIKSLEYTIRRKEEEERDITSLLNAFRRKVADRVTDPHLRTLLSSVMFRNPERFYTGSKGEADFLQEFNEPLMNYMQELRQSDPDVYKQLIEYLQHPLAGSRNDDVCDKLIALAKQEGDRGENFRSLKRSLPVLLSSLNEAANMGSDYNFEASISRKGAVPGECDTSAFGVSHPLKQCDSPLSVFNSSSGGPANITLRSTTQMPADDKPTVEGEIYNFLKNLQTSGDINVFTAQMAPNGADEAYVRQIRSTFEFILQTRGTLVRQMAILWRRAYKGLQVVKALASSNAREIALSQKSSLKSSVNSSSPRGKSQKLGAVAIGILDELSSLVSSIISTLFTSTEKQRIEFTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G7</accession>
    <name>F9W4G7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29780"/>
    <dbReference type="OrthoDB" id="1608486at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Rad51"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="Rad51" evidence="1">
        <location>
            <begin position="176"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="239" mass="25751" checksum="4E5B67961CFD8B64" modified="2011-10-19" version="1">MRHTSPNPTLTSDLLRAVPSVKKDGLEKALVAALLRCSQGLGVKSLVDLLLLLVADQPYVQRFLICAVKEGRGRLPPCSPEDLQRFTDKVLMGLSNHHISQVYGGLDVCSNSEKSCEDNLTFPAISVAEMLHKGTIFRASKGQPKGVTVMTRAEKGILFFPTGCTTVDRLLAGSCSDASDDALEGGVRAGLLTEVHGEAGSGKTQLMLQCLLQSVARYQCALCISLLQPTLIRARESLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H1</accession>
    <name>F9W4H1_TRYCI</name>
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    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000554">
        <property type="protein sequence ID" value="CCD12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29820"/>
    <dbReference type="OMA" id="DHINSWM"/>
    <dbReference type="OrthoDB" id="1268461at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="956"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1099"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="790"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126040" checksum="A33EA39DFE2D8EC5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J3</accession>
    <name>F9W4J3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000561">
        <property type="protein sequence ID" value="CCD12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1720370at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20619" checksum="5886B877D327E3B5" modified="2011-10-19" version="1">MRAAWMFAHFAWPGTINGRRFLRPKVSLKILSRAAGSQRRRLRRERVRRRFRAAWVHGPGSGRRGSCPNRHESEAAAGGRSCSIRRTAPRLNQQSPQSSRGQGFPPIALKVQRVPLQSSWAEPRRGPSLPHASRKHGEPKSWRVKRREVCGAAHRRGKVDRGRECERHAGAQHRHLMASLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S4</accession>
    <name>F9W4S4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000598">
        <property type="protein sequence ID" value="CCD12169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30780"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17066" checksum="5E1341752D222B32" modified="2011-10-19" version="1">MEVIASSKPVRVLPARGKARWDEFRLISDKLLSQRVKRSVKGVDALNEAVKKGVRQTAEKAIHKGNGVVPPFWTPELTKLDVMVQQCRNERKRDARIRWRSKVPVDTAIRPWEDNVSRPTVTNPISRNLFKSIYALARSSLGSPLRRSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V3</accession>
    <name>F9W4V3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000614">
        <property type="protein sequence ID" value="CCD12200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31060"/>
    <dbReference type="OMA" id="FHIENPH"/>
    <dbReference type="OrthoDB" id="1065583at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="554" mass="58034" checksum="CCC2F838954B0397" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4X4</accession>
    <name>F9W4X4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_31250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000626">
        <property type="protein sequence ID" value="CCD12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31250"/>
    <dbReference type="OrthoDB" id="514396at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="49"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="40195" checksum="8BDB95280401ED4A" modified="2011-10-19" version="1">MREAICIHIGQAGCQVGNACWELFCLEHGIQPDGAMPSDKTIGVEDDAFNTFFSETGAGKHVPRAVFLDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAANNYARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVYHAVGGGTGSGLGALLLERLSVDYGKKSKLGYTVYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAAMLDNEAIYDLTRPLAQPATSTWCQGPVLFIGEEAKCQLRSRCYRVRSWFLAKGPEGCILKPSCRPPVRVVLSTTVSNVMSAHLRHPNRQCALQEALRQKLLLCGDVEANPGPLTVLQLNVQSLTKTKLSSLLSRGSDIIIVQETGNRKRISCLEYISLNYVPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W547</accession>
    <name>F9W547_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1274</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000656">
        <property type="protein sequence ID" value="CCD12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31910"/>
    <dbReference type="OrthoDB" id="1755503at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388689" evidence="1">
        <location>
            <begin position="17"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16909" checksum="9E515791CDDFCE11" modified="2011-10-19" version="1">MWVCVVRGCCCCVVVCVRCPSFVRIIPIRMRPGVVCGVCWGNRTWWGAAVVPAAISKTRLGARTCPNTRPHVALFLLCCEGAYGCVRAPQGQGKRGWGKRRVLMPPDAYCVRTGSLFSLFFSSSSSSFPSLPTCVGRVEEEVCVLGGRRCSGEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L5</accession>
    <name>F9W5L5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000728">
        <property type="protein sequence ID" value="CCD12467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03410"/>
    <dbReference type="OMA" id="QAEEMYF"/>
    <dbReference type="OrthoDB" id="986860at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="282" mass="32881" checksum="4C7BE3FFF03A9FD9" modified="2011-10-19" version="1">MSESRSDVPSAGVSGGRREVLSDIKRRREKLELYQSSSHKMKSLMMNSAGIHSGLGNNELPSNPIWMKFPTRCVKSVGSVDEMREKLKYFSHSDDVMVVRYHQENCTACNALDKAFEFLCHQSADRLPNLKFYEISKSSTPELTKNLVRYPQVKGYSGGHWTDLEFKPPTEFREELYAGVEREVVRRKREGRPVTALEAEEMYFSAAGPAMTQVLEESITKFYCKAQARLHNYWKQVSVRRAWFFRRFIEPKIDEQIREEWRLKSIFGEKLLYGPEPRVEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L9</accession>
    <name>F9W5L9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1340</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000730">
        <property type="protein sequence ID" value="CCD12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33480"/>
    <dbReference type="OMA" id="IDERRSC"/>
    <dbReference type="OrthoDB" id="1730607at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="20906" checksum="A12357C8A90FD0BC" modified="2011-10-19" version="1">MGYSELRPSHPYSSPGCITVTSCRTSSRPNSHGRSSGTSSVRRQGSRVYDPLNASRNGWVRYDSSLARSLLNTAKKIDERRSCHSSLPNLSSPSRSRTSYSRMSNSTASTVGPSSRARMCFEPALSGYSPLKKAKLLNNGATAAGGELNAKQLTNAFYGSNTSGKFAEAAYLHFVADINRQQMQRMGRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5M9</accession>
    <name>F9W5M9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 134</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_03430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000739">
        <property type="protein sequence ID" value="CCD12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03430"/>
    <dbReference type="OMA" id="IRMRAAC"/>
    <dbReference type="OrthoDB" id="708294at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394701" evidence="3">
        <location>
            <begin position="18"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="452" mass="49677" checksum="D01AF30604A57E9C" modified="2011-10-19" version="1" fragment="single">MHLGVGLVLLLVTATFACDVTFGSVMGIDFGSDYIEIAGPINGVNVNIVLNEQSHRKTDNYIGFRNGERSIGAQAKSLAARFPQNMLTMINHLIGITRNSSEFSNFKQLQCEFDPLAEERDTVGFNFTDTGDTYTVEEIYAMMLNYCRSTSRNAGVPSPESMVITLPYNSSFGKRQSVLEAARLVNLNVLGLMHSTTASALYYGIRRRGFGNRTVNVLIYDIGSTHTEVGVFKFSPPVQQPGKRVRNVDSFGTLTTLAIVADPTLGGRTLDLCIAKGIEAEAMSKIKISKVLGGTTIAQKKAQFSLFRAAKHAREVLSANSATPVTVEGIAPERDFNTVISRKDFEANCSELFKRFPVVAREALNKSSLSLGDIDAFEMMGGTSRTPKIINDLSAFWGREVNRTLNSDEAAAMGAAYYALRLSPHYRPHSFRIIERIPSTLSFVVNPRCYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R3</accession>
    <name>F9W5R3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33880</name>
        <name evidence="2" type="ORF">TCIL3000_6_1560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">IL3000</strain>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="6"/>
            <end position="28"/>
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        <location>
            <begin position="35"/>
            <end position="58"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="143"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="355"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="375"/>
            <end position="396"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="417"/>
            <end position="437"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="CCC90922.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD12516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="578" mass="64707" checksum="9CEFF48DC7173CF9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
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                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
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                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
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                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">IL3000</strain>
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    </reference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
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        <property type="match status" value="1"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="68347" checksum="18122BA0BD1067A0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5T1</accession>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
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                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
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                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
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                <person name="Quail M.A."/>
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                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1717084at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="20137" checksum="C4DD6620BD530411" modified="2011-10-19" version="1">MKSLLVVMMTFVESRGNNNKQLNKVEFEDLFSILRIGEDVVNKIPNKLRNYIEPHNLLKKLLYDTQTPTAMFQKVIQLKQGDAEDTKSTLYTVKRRNANDKIQHVMEKTNDTYSLMEEELIQATRERTLVRNNLAHVIYGVQVGEPQKEEDISSLMQNMSWSSISNKMADERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>F9W5U4_TRYCI</name>
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    <organism evidence="1 2">
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000772">
        <property type="protein sequence ID" value="CCD12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03480"/>
    <dbReference type="OrthoDB" id="1730751at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17700" checksum="E4F4527F5647751E" modified="2011-10-19" version="1">MKNGKGIRWREMVVTCANNSHCLPPAEALARRLCGVSLFSSGIGEGSVSVKAKGLRCLHELVLELSIGDVCCFCSLHEGESAESVVPFRVIFIISLPPYSSLSSFSTMWSFLQTIMLSCLNVYSCPFFFVVQLEQVHRVLPFWKSVGNMHTFSPLPPSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9W619</accession>
    <name>F9W619_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1413</fullName>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000811">
        <property type="protein sequence ID" value="CCD12622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34840"/>
    <dbReference type="OMA" id="EIYIISQ"/>
    <dbReference type="OrthoDB" id="552980at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="331"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="430" mass="48457" checksum="EEB4A449EB13BC49" modified="2011-10-19" version="1">MAEPFSSILGSDGASGNCKYLKKSLIGTGSYGEAWLAECVGDHSMCVAKVMNLDKMSDRDKRYAQSEIKCLANCNHPNIVRYIEDHEENDRLLIVMEFADSGDLDRQIKMRSSKDVRYFQEHEALFLFIQLCLALDYIHNHKMLHRDIKSANTLLTSTGLIKLGDFGFSKQYEDTVSGDVASTFCGTPYYLAPELWSNQRYSKKADVWSLGVLLYEIIGMRKPFTSTNMKGLMSKVLSGSYAPLPQSFSPEFRRVVDSILVVDPNQRPSVRGIFQMPYVNNGLKMFVPALKRNEHVSDTIKELILSQVAEILSTEVEPDSCRYLVSQINYDVSHRGHVYKVGGAERAWKPRFLKIERGQLVLTDDEEGHNPKGLSLEQVQGACPVPPRTAGRDFVFALNTVSGKGMWFQAASHDDMEMWVHTIQRGIGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D6</accession>
    <name>F9W6D6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000852">
        <property type="protein sequence ID" value="CCD12741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35950"/>
    <dbReference type="OrthoDB" id="1750111at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20161" checksum="3C4EC216B17A37BA" modified="2011-10-19" version="1">MLISFVLLSLCSFVVSFLTSSFLLALLGGRVIRSALAVSCQLCCFYYYCLVGSRTDTGWRRGKGSMGDLSRGGWLHWTSAPAVVSCLLSLSLSIFGCFLSCVSLCLLAELFYIAASLRLEFFFSLRGLLGEFGMFSIHILTVPCANVSFVSRYLSFYLFLLTINKRERKEGEKKGEDKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N7</accession>
    <name>F9W6N7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000900">
        <property type="protein sequence ID" value="CCD12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36850"/>
    <dbReference type="OMA" id="KTRTAGW"/>
    <dbReference type="OrthoDB" id="1192021at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039986">
        <property type="entry name" value="CFAP210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28663">
        <property type="entry name" value="PTHR28663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="512" mass="61043" checksum="86E3F8139A9091D1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Q1</accession>
    <name>F9W6Q1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1501</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000909">
        <property type="protein sequence ID" value="CCD12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36990"/>
    <dbReference type="OrthoDB" id="1726491at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="16730" checksum="9C6BD0FDBBAE6BEC" modified="2011-10-19" version="1">MEHSLEARCQCMSATSSCRGGTPIPLRGGVGVVKCGKSLGAVEEESATLLLGQGLCVTFPSAYYPVRLGFTRYPPGSLRSAHGPTTIVADVGPGNRAWVPLTKPDDAGESTAQLCWNLRTLLRLQDDLRIFFHRVGCYGTWKTWSIELAAGDETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W707</accession>
    <name>F9W707_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000960">
        <property type="protein sequence ID" value="CCD12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37840"/>
    <dbReference type="OMA" id="NQGDYGG"/>
    <dbReference type="OrthoDB" id="334343at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="589" mass="65602" checksum="ACA7A7BB1A0AE50D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7A3</accession>
    <name>F9W7A3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15043" checksum="0311CF49A66735B8" modified="2011-10-19" version="1">MVIQKCAATSTMTNEGDRTSPNPRPISLLMTCSLSPLHPHLTIRTSHHPKEKREVQWVLPLPLDRPCHSFFLSVHHTLFRAGLANCREPVFPPQSCAPPFINSLQESPCLVFGLVLVLVLKGVCAPRDQWSRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K1</accession>
    <name>F9W7K1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1622</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_39420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001045">
        <property type="protein sequence ID" value="CCD13168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39420"/>
    <dbReference type="OMA" id="RGNAKPQ"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="244"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="587" mass="65521" checksum="67B4DF41A3BBF63A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7U7</accession>
    <name>F9W7U7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001081">
        <property type="protein sequence ID" value="CCD13269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40380"/>
    <dbReference type="OMA" id="PPRIGCF"/>
    <dbReference type="OrthoDB" id="1029814at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36122" checksum="C92B738F8D8F78FB" modified="2011-10-19" version="1">MNAIFDAIDRNDYEALRRMFSSTSINEVNSDGYTPLYYACMKKHVNVETIDEILKLGAQVDLKGADGETPLYVACFNGRRDVVMLLLENGAHVDTINGRCGESVLHLVSRTGDSTLLDFFLSRGADLNARNMRKETPLFVAAKLGFHEIVYRLLRAKASPDVCDMDGKSPLYIASERNLKHITILLKSGDKDLALSKAAADEFLQSRPTRLKTTEEICDEAVLRGGEHKNSIREVPKETKPLDIIDIVIPRPKGNLSNLLGAKPKGPCLSLEDVGFDAPPVIPPSLRNLPPVIPQRIGGTMMRIGTGINAIGVEPIRIDTVPSDTMNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W1</accession>
    <name>F9W7W1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 166</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001088">
        <property type="protein sequence ID" value="CCD13283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04360"/>
    <dbReference type="OrthoDB" id="1694197at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="24193" checksum="CEABC258E3B8B96F" modified="2011-10-19" version="1">MPRKLLWQCFSKGPKLSEEGMLLFLFMSGMESCCYGVCKRGFNKRRHLVTFSVGYPFIIKLTTKQVEFRTIFENPPCYAAALKALAVSVTGNPTSFSRYACTLRKANDDRSASLGQPSVIWLFRQQPTRLHESTELILPPKSLPSYGACPLKPVKAHVCVESSILHILLAIGVHDINSHHSGWQTFHLLLYIGIEWMMDLCAAVMTWAWRLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W830</accession>
    <name>F9W830_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001125">
        <property type="protein sequence ID" value="CCD13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41140"/>
    <dbReference type="OrthoDB" id="1783172at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17887" checksum="A9AE0CCDDD0C147C" modified="2011-10-19" version="1">MCVTRKKESRMGFKHAPACSLVTVQSICSLFFFFFTKKKTNFSSSPLTMPLYYLSLPLSIPFMRFSDFRSSLITRVDGYAGAAWPGWSWWRLCFSQRNLWGSDGNNLEGVVLADYPFEIFIFIHFVFPFFFPLSFGICLFLFFFTFLSWLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8A3</accession>
    <name>F9W8A3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001152">
        <property type="protein sequence ID" value="CCD13434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41830"/>
    <dbReference type="OrthoDB" id="1655355at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="753" mass="85094" checksum="1F28B61CECF4194F" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8J6</accession>
    <name>F9W8J6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1739</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001174">
        <property type="protein sequence ID" value="CCD13528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42740"/>
    <dbReference type="OrthoDB" id="1719931at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17524" checksum="84583790924A7D00" modified="2011-10-19" version="1">MYQLEAVPGRKFAALRVDLEVEECHALNESVCSRGSDQSELGPTERHINDTLGVLLGVFNLEQRQKLLKSLCERWGVPLPRKSPGVWDEAFGRRVRRMIALRVGRVADVGMRNSVDSNATRFVAFSPLALGAGDCPVDFEEGASAAECLDVRRSSLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L4</accession>
    <name>F9W8L4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1745</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001181">
        <property type="protein sequence ID" value="CCD13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42900"/>
    <dbReference type="OrthoDB" id="1719810at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16917" checksum="DBE149B871BAC72B" modified="2011-10-19" version="1">MPCADQRVWAQQPVLPPFIPKLFLMQTPHLRRLQSRADPKSMGRLPKNITFSPNAATGSGGVGPICSTACCLRKARKNGHISVKHHHILILEVFFHVARKAPHVCNLVGTTFHSNVITGVSVGRNSRAPCSRLGASTLSSSPWKVYRAAHQLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8V1</accession>
    <name>F9W8V1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001222">
        <property type="protein sequence ID" value="CCD13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="107" mass="12598" checksum="78C8C082E3079EAE" modified="2011-10-19" version="1">MRKQLHLGPPIGQTDLMKFSSFSRMASYTSLQNIIFTSLLGQTETTFTKQVFIPFSFTLRAFSSKSSSWLFFFCHQREYSRGCKEAREKTRMYERVNTKGKRILDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8X4</accession>
    <name>F9W8X4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1792</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001233">
        <property type="protein sequence ID" value="CCD13660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43960"/>
    <dbReference type="OrthoDB" id="1369716at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="205"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39984" checksum="59329DF04DDB9862" modified="2011-10-19" version="1">MYLQQIVNTMSIKNWIVTTERVKNKSEGLSEYSSYLVSSKHKNHKNTTIIPLFKIDYNNFINKTILETIEFDSKNKKGGRKVESYAQSFNFILPPPHKPTISQWENITKDLLVTLCNELNIKEKTKFGKSCFMNIHDQSNPHLNLLVPRIFDGERLADLDRKNVLAKLKLQFNQSVMKHCEIDHTKHKPLRSNNGPRKSAQRYAYDKAKEQAENALKLIAEAGEATKEVALAEGEIKVKLEELDKVEKELKIQNQRLGFLINAYTKFKDTIFSWANSARKGLTLETMIHRQELEKNANAIIDSKFVSDKDAFLVEQTVLREFEELEKDGIETVKPEISSRLTKIKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W921</accession>
    <name>F9W921_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_04670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04670"/>
    <dbReference type="OrthoDB" id="1744445at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394783" evidence="2">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12659" checksum="BCB165EC66EB8F45" modified="2011-10-19" version="1">MLPARNTCQSLPFCIAWLHVVFLCYAYFCCGTPPCIAVGVHLPGVWSGIILIVFFRVCSQPDRRYGLMSLLHTWACSVELITNDSIARCEDNRSHTKLQDLSLLCAGAYSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W924</accession>
    <name>F9W924_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04700"/>
    <dbReference type="OrthoDB" id="1688020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="26369" checksum="43D497D6D9140527" modified="2011-10-19" version="1">MRFSAYILTTIPYLGARNVRALQGWAVKQAYELFDHVPWRVLEKASQGTHLWPVSLFPTLINSASDPDDLEFSSDSPTPEGTVLPDDAPRHENWTLLSGIQDILQEGCETWEHVSLADYFKECGICFNEEDLPTANFPELLQSPAQHIPCEKWRKRVLKDMSAKLDAPKTRVLGAVDFLHDKGINILDIWERSMFKDCGLAWPIRILFSTTGERVWVHRCERWHFIHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W936</accession>
    <name>F9W936_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001255">
        <property type="protein sequence ID" value="CCD13726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00450"/>
    <dbReference type="OMA" id="SHQCESI"/>
    <dbReference type="OrthoDB" id="524627at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21713" checksum="AE66CBCC8B65D621" modified="2011-10-19" version="1">MRRSSAFFAATRLSRESIRSAAKTKGSVSTGKELRNGFDRLILAPVSESGKSQTVWKAVAGRPCRLRACWCDARVDIVPYANVLHYHCKYEQLTNDLGYEMEPSRKFITRGSRPSGRHDSRVSVKSSDRRKAMTPWQGSSNTGYPGNRTTYQGCKGTSHQCESIGFYGKPRPDKRSVVFFSDQHPMLARGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9C4</accession>
    <name>F9W9C4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1848</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001295">
        <property type="protein sequence ID" value="CCD13824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45200"/>
    <dbReference type="OrthoDB" id="1736385at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389993" evidence="2">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17219" checksum="17228D4CBE794513" modified="2011-10-19" version="1">MRLRAYILATILYLDACNARTLQYWPVKQAYELFDDVPRRILEKAAQDTRQRPVSPFPTLINSTSDPDDLESSSDSPTPEGSVSPGDPRSTRTGLCSAGSKTFSRMDVRSWSTCRSPITSKNVASVSMKRACPQPIFPSSFKAQPSTSPVREGGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA68</accession>
    <name>F9WA68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001401">
        <property type="protein sequence ID" value="CCD14124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47840"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390031" evidence="1">
        <location>
            <begin position="20"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="24519" checksum="A451168E528ED30F" modified="2011-10-19" version="1">MLRKFELVGLVFCAGIVCGQHPSAAEFNLFCRILMEANNMMYGPDYVYDENTDREAIKEMTVLYNATTDDVNEFRKTLWDTKDFFEEHPPPTDAKNRQAAHREIEQLIKEGQEKVEENKKIALEVNEEINEAKLSVAKGISVDELKELPKQNGNLKKILKKPESIFNDHNSATTSCWGNEKDTAGKTLLNDFFASACGMLGNKLKDHAHPYSTTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB08</accession>
    <name>F9WB08_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2044</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_50500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001513">
        <property type="protein sequence ID" value="CCD14435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50500"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390084" evidence="3">
        <location>
            <begin position="23"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="587" mass="62206" checksum="B034936F709F7756" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB27</accession>
    <name>F9WB27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2051</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_50700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001520">
        <property type="protein sequence ID" value="CCD14457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50700"/>
    <dbReference type="OrthoDB" id="1671416at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390083" evidence="5">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="104"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="39483" checksum="40894F1D71B2794C" modified="2011-10-19" version="1">MACFMNAIAVVIFSLFGVVRGEVKVEKDDNIEPFSLLCRIYNVAKNPPINYVDMEEGYNIVEEIDDLNTSLVEQKWVNQTEQVGDDEVTGKEHAKISVAVTKETALAQLSLNQITQSVHTVLEEIKKMKVTKKIEKTKDEFVQVIFGEGGNEDDLCHSTVKGVVNRSEARGNPGAGTNGSHAGKNLVVDFFCLCVRSPEEEGVNQVCGFYVGIKNGVLGWNESKPMGSSTMWASIKGGCGKHMHQHPKSTAEARHILDQFLKHLKTGGVYRWVDGSGKVQGSNRKEGMLGTGVGKEDDGGGPVCDGKNGKKGRGTPAGGICVYDGPESDNWEANIAWLKKLKTALASVDAANNQTATIQGALQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB30</accession>
    <name>F9WB30_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001521">
        <property type="protein sequence ID" value="CCD14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17304" checksum="E0C89D13EF700A73" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVDVLLEGVTSPNHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAVWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKLYVLNEDDLKEVITLHICPSFHSGLLWCMISTAANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB46</accession>
    <name>F9WB46_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2059</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001529">
        <property type="protein sequence ID" value="CCD14477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50870"/>
    <dbReference type="OMA" id="AVWENSE"/>
    <dbReference type="OrthoDB" id="1046479at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="368" mass="40590" checksum="091FD81FFBC84A02" modified="2011-10-19" version="1">MHAVWENSEGVESAYPTRWLTQLLLDGFVSRRVAAHVGLSADHMVETVAAARQLKVPLTPREVSPYYFANNLLSSWGIFGDIKLDDAESVRGSVSHIIQLAHAASTIPIRRSVWLNGAAICNGRGDAVVILGPKMSGKTTLALHCLSEDAAHLRLIGLENFHLAAESSVLSGEDSPTGYQRALLSGVPTSATVGVGALMGSLRPNPSLVRAAHNFDCSSATIQCLMRNSEEVIWFMDRKHSVNINEAFGPHHWCPTWFGRLRGIILLNWDIQELSRPTSSASMRLNHWSERADCVKVLRAFAQSKRSALLKGHYLVRSIYDELRAQSQLEEVLFFGNDVPPVFELRGAVHFDAAVNLICHRLLKQVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB53</accession>
    <name>F9WB53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_50930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001533">
        <property type="protein sequence ID" value="CCD14484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50930"/>
    <dbReference type="OrthoDB" id="1672682at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394649" evidence="5">
        <location>
            <begin position="20"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="39334" checksum="B6FA9AB54B4AA09B" modified="2011-10-19" version="1">MRMVKFCFIVFLVVMGVLASFVVGEEEDHNKGAHERLCNVLREAVGMWEDGGARLSAPLKTALGRTIFGKDSDWGTVVSLKNSFPSDYKGVSDTSGSRYFLCGDQPQQDHSPMAKTARRPGHSAPHDLVCLCTAGDGGWPVNGTVGGEQTLCGKQANKLGVETEKKGWSHKKNEGENQIQATWTNVVQECLQGTDKGTRLKDALNTFIEKLGTVTSGANTYKVLGYTGRDAYPCSGSKIQGICVKYYPEEQNAIPWWKQLEDAINKDEAEKQQKRREEESSKQENSQKRRDPQKKDQPQPTQEPRTAALRSAPQSSQEDEQDNTENISNPIATLEDTSGTPIISPCTWFLSALLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB68</accession>
    <name>F9WB68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001540">
        <property type="protein sequence ID" value="CCD14499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51080"/>
    <dbReference type="OMA" id="CAEVANG"/>
    <dbReference type="OrthoDB" id="1683048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390089" evidence="2">
        <location>
            <begin position="30"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37178" checksum="DF6D4F739A497CFD" modified="2011-10-19" version="1">MTRSGYDEKSALLLQMCLIVLSCPMRGLGEVVVREGGTNVTALCDLVQGLNGLPWEVIAPMKAMVFQNVTVASQSGMLVAIEVRKAYAAMKRVQLFDAPDAASNVSDAFESAKRAAVSCSADVESARSLLKHFYDVGHEALVNARLANSYLRTLLNAGSIECQGLRRAAQECDTRKRKRVTADSLRRDIQAAVPSIHNSSIIDCLVATHKLLEEAEGIATAVDNARRGAARQVPVARVAGAAAAFAATKGLVPPPAPSPPHRPSDPERSEKPFYVILLVSIILMTIFFLWLLAKLMMQLCEVCYHRKRISQARRMTGLDSIRPARWNQVLLVEDCPRRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU2</accession>
    <name>F9WBU2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53210"/>
    <dbReference type="OrthoDB" id="1720564at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17359" checksum="C047A5061E025E5B" modified="2011-10-19" version="1">MRELETGCTYKPLIPNFPLVDGFFVVEGVGPNTIVLLQVTKAKEHHTKRTTVRKFLQCMGKAFECREKVEKACSWEIMNVQHVDSGSIKRRWKCCTSGDAAGDERLALWENTRQYRVSLNTDIASEFISRGSCWRRDPIRRVRQSRAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC71</accession>
    <name>F9WC71_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001677">
        <property type="protein sequence ID" value="CCD14863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54370"/>
    <dbReference type="OMA" id="TAAHFEY"/>
    <dbReference type="OrthoDB" id="244497at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1490"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1662"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1491"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1688"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1774"/>
            <end position="1792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1793"/>
            <end position="1812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1812" mass="200319" checksum="0C90A1A170DE76B9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCI2</accession>
    <name>F9WCI2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001726">
        <property type="protein sequence ID" value="CCD14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55430"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="18071" checksum="5C40B7C366B9361F" modified="2011-10-19" version="1">MKKLKKMEGGEDQRSNLSFDVDINMSLRACLFVACVCLLTCFCLVLFCFFFQMYTFELFFSFFSSSSPPPLHYFFRFGFFCIFFVILPSPLSSLSLRACVRVHPSLKSSKEAKTFIFCFFCLICYFIRNEGGGAARRRGRGGGSKQLAIYHIITSCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCI3</accession>
    <name>F9WCI3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001726">
        <property type="protein sequence ID" value="CCD14976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55440"/>
    <dbReference type="OrthoDB" id="1755771at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19009" checksum="F241ED18C7BB4AE3" modified="2011-10-19" version="1">MCSFFFPFSIPAKYCDALLPPSLFPLPLLFHFPFFFLAPSPPFKCERVTGLYISFPINFFNYNFLPTTHIPHPDAVPRAVMGPSRDARRQQQQQQARLRGSCGASAAGDSHKSSQRGNAEGWRWRWWCWCWVGEKYVFQRFFPSETREANGRSGMQSSGSEREVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCR2</accession>
    <name>F9WCR2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_56240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56240"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390179" evidence="5">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="43552" checksum="A40085BCC54FE340" modified="2011-10-19" version="1">MIMKIATWLLLWIGSGKWLGMNGPALRVSARNEEAGTLLCNALRAAEAIRKHANVTQDIKDKIHTAVYGAAGGVQFTEDGRLSVGNNVPYRKQYGRHTVCEYYGKDRQVDKIGGAFAESLFGTFVCVCAPPITDRNAKLCGVYYWERRRAWSGYFNGGRIDKNLLRDVWLDVIGKCTASTKGHEGDLTRVDRLNVALMAVRSALRWRRGSEGYVYVLGETRDIQGCSGRNANDICAAYKYETGKLAIPWEQSLRNLLHQLYARFEKPRAVRTQETVQWTNPVIPEASGISQQPQQSFPSLPREVPVDEEGHAVVLQDDDFPNDQPNSTEAGWEAENHTSVSAREPEAEKLQGIEGTPDSEDTVVAHLDAETHEGGSLITQPFWLLTAASLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD28</accession>
    <name>F9WD28_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2312</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001811">
        <property type="protein sequence ID" value="CCD15176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57250"/>
    <dbReference type="OrthoDB" id="1007980at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="PTHR15002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="24803" checksum="E3C740FF0524C05E" modified="2011-10-19" version="1">MAGKRTRTQRDVVNRSRLNGTRIKKGLDELRDLDAKPQPVHTVPSERSCEGNAMRGKAVASRQGAAEKKRKTEVASAADGSTATKRNEKNPSVVPETIINTANSTKHCGNSSPCVFGYSWEEWKSVKRHLFDTTDKKGTAEARRRALDHVELVWTARSRHGRPLPSYVESTSLLLEVVSLDECGQLSSTAITALYGAVISRTVHLMTGTFARGDDDPYRKRGTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD87</accession>
    <name>F9WD87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001836">
        <property type="protein sequence ID" value="CCD15238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57800"/>
    <dbReference type="OrthoDB" id="1665524at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394688" evidence="5">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="26"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="78"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43949" checksum="DE92D2558DF8F947" modified="2011-10-19" version="1">MMKLFMVMVVIMGGLVREWRVMANGDVSVDGNDNREPYELLCRIYNVAHNPPIKPVDTKEYQKIVDDINALSAAANGKERINTQTEEAKSAQTQLIGISRDARKLLEEIKKVNPEGEAQKARNAFNAVIFGEHGKEGDLSQGELRGVEGSRLRSCGSKDKEGTTAGKSLLVDFFCLCAKHDEAEGVNNVCGVSVGDGVGMGWGTKLQLADTMWNAVKDGCKMFAPQRVTSTQDGYSLYHEFLEKVKAGAKVKLNNSGTVQQHGMLGTAVSASRDTNFNCNGQKKVITTRDKISSGICVFYGVGKVKEGIIWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKANTQQEEEDTEESPLTQHPNPDETENTDSTTRSMRHSFLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD91</accession>
    <name>F9WD91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001838">
        <property type="protein sequence ID" value="CCD15242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1663020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15046" checksum="56768D2D3873933C" modified="2011-10-19" version="1">MLGTAVGDEGKNGADLICDGSRGNGKGQPPAGICVYYGQESDWQTIRWLVKLKTALNTVDALNNQTATIQRCIEKLQMLLHRAEKIYETKKVITEVQHPVGLTALHNPTTKRLTAYSASRRHDTHAHFHSLWLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA8</accession>
    <name>F9WDA8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_57960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001846">
        <property type="protein sequence ID" value="CCD15261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57960"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389003" evidence="4">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="83"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="48929" checksum="B1D51452CB0B1326" modified="2011-10-19" version="1">MVIVKLSLVALVFCAGVALSGKKPPSAKEFNLFCRILRVANDMMVEPDYVYDENTDRETLKEMEVLYNATTDNMNDFRRTLWDMKDFLKEHPPPIRLENRRKAHSEIKKLIIKAEREITENREIAVEVNKEKDAAKWLVLQGMYGDNVKDVPREEGAWTDMRNNSENIFVNNTSAAESCGNNSAAGKTIFNDFFCVCVGEGVEDTEGPCHPGIMAPKRALKNNKHCYEDANSDNCTKWTEMKHHSSSIPPIPLVQAIGKIEQRCRIEIGKEEKVKDIPNLLKEFIELIGVGEAKNGTDAENIFGHSGRIKGNGNNNVNQCTGAGITGNKGQPDYHNDRICVDYTKNLKEGKTYEIPWHNKLKEAFDKMQEAKKIEDKIFQNHADILLLKTKAWTAYSIEKDDETINLDDMNISSIFEGAQLPPLFPFIFLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDF8</accession>
    <name>F9WDF8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001863">
        <property type="protein sequence ID" value="CCD15311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13959" checksum="B47322423CB9F040" modified="2011-10-19" version="1">MWWNHSCRLHDCQHPASDTRCACSADRCVGLGPVCVCGRLACRSWMGLGGPVRFWCLSARSMVPLCGLGEPVCCAVPRLYLNKHVMISRVSLHFHSRAFAAQVLVSCMLLLCLANITGCMLIFYCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDI6</accession>
    <name>F9WDI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001875">
        <property type="protein sequence ID" value="CCD15340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58690"/>
    <dbReference type="OrthoDB" id="1663213at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="414" mass="46657" checksum="5B548626EC79983B" modified="2011-10-19" version="1">MCMVCCCLMSQKYFFFPLFCIGMENWKPMRIRNGIMVMVTFMAMVREWVWGSVEDYESGYNFNGMDHDALCAVFQASADLWNASRNSDRRLTKGLEKYLGQSLFGNTGSRNLEAITDALPKEYNNHKISQRGVLCGTCKYREQPHYPGKSIPHDLMCLCTPGKYGEPFYGYWFFGLISEDTGFKLCGKEKTDMVNNNHDGWYEDGKKKGKKGLEKPWKAVIWGCLNQWKNKVTTESQDLAGKVNKLIETMKNFTTVVKESKGRSKLGGMHDHHTASDGKDEKSMHVHYDTCRGIRKPWWKKLNETLNGKNPEALLVDRSTTTPSEEGMEDTDGESEFLEEVENTESEGPTPLAGSALQSNNGTQIQGPTNSTESTVTPLNTSATGNSSHPRLEYLRSGSQINQPLLFPSAIFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDK7</accession>
    <name>F9WDK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_58880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001881">
        <property type="protein sequence ID" value="CCD15361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58880"/>
    <dbReference type="OrthoDB" id="1678748at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="63"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39656" checksum="3E3A4F39DD5DF605" modified="2011-10-19" version="1">MTIIMRYVEMMMVGVMVIGADAKVMDAILDTSDFDLLCNVTKATVGLWNSVGQLSEFVDPDDEKEFSKTINKIFFGGKGSESHMSIWPLPDQFKKTTANRTKVCGYNSDSEETPSASDSLASLLLCLCTPRNEAEKHICGFNVAIKGIWPEDGKSTAVKGVFEEVWDGNGIEEQCKSHGSDDMEKEKQNVVGNITILEAALESKTELLRQESIKDKGKKPSAHVMKIPTWLKLLKGIQLPRKIDPEPQPEPPSSISAKDTEHESTAVTEMPPSSSAPETIPRSAPISPQVREENPEQETKRIPPPHINPQPEPKPKKKNTEVPEKPAENTEDPLPVPENETSSSFIVNRRWSLSAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDM0</accession>
    <name>F9WDM0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2379</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001885">
        <property type="protein sequence ID" value="CCD15374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59010"/>
    <dbReference type="OrthoDB" id="1721625at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17279" checksum="B69EC29386D20B91" modified="2011-10-19" version="1">MEPLIGLWAFRKNFREIAFSRTLRPYLAIMRRRIGAWKNSDIRATPPFSRLFWGSIPLWGMWATRHSQVGIIPSEMLPVTHAKAFSSLLQLVHSALFSLKPFSAEHSSLWVADYLHCLFGPLFLRPFQCLLTLARKMHCKAPLCPSIKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE26</accession>
    <name>F9WE26_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14208" checksum="4E2ACC0475F80BB1" modified="2011-10-19" version="1">MSVKRAAKESLMRLLKLKAVVSQSGDRSGGPYAHSTKHWFRPKRATRSPCGGPVPRPRTRSPWSAFRAARQVRWWMSRCEQPLKISGGMRPATGNVRNRAQGGCSTTASSKSLHPQAARNSRKVAQRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE48</accession>
    <name>F9WE48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2439</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001952">
        <property type="protein sequence ID" value="CCD15554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60460"/>
    <dbReference type="OrthoDB" id="1719472at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17902" checksum="F04F6C3F0A123A18" modified="2011-10-19" version="1">MYHLLMCVGCWNPSLHTGDLAYFDYTNVLATPCPTRHDAPLHDLTRIWRHFFSPSSCDHSARMYHVINRVVEIRRHTACPSKSAYDLRKSVLCNPFLLEEVPHFIPKLKLLVDLENTAPHFREECKEASFEDKADKERLKQNKPRREGARSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE68</accession>
    <name>F9WE68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60600"/>
    <dbReference type="OrthoDB" id="1700199at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="22616" checksum="3D9900FA319FABD1" modified="2011-10-19" version="1">MLKEAYAVAVPESLGLTRVRTASPPWTTSSTVDNVLLHELKDKRRIHLYHFPLDYGWDSPPSVGLEVTLGAFLRDPRDTVVEEPVRQQILQHMPGMLSRLYGDLGLDLRNLLARGIRTLEDWAHHGWYMVDLSALSEVILEEVLYAVLFFLEHNHENEEGSCAGARSGLLEGRRGKPSLPMRKRKRVDFEGEGGDPFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEE5</accession>
    <name>F9WEE5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002000">
        <property type="protein sequence ID" value="CCD15652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13754" checksum="5F474CBD977A96DD" modified="2011-10-19" version="1">MNAVLNGEFMVRHTLFIIPVGWHPFFGKRGLLVFITGVNITATFPPAITLGATLPHCAVMIETPARNVFSQSRHLPQSPNITMKSSGNSWCVWGTRMESDRHCLNSVRAFGTQCPSTYACYLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEE6</accession>
    <name>F9WEE6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_06710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002000">
        <property type="protein sequence ID" value="CCD15653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06710"/>
    <dbReference type="OrthoDB" id="1662949at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394938" evidence="5">
        <location>
            <begin position="37"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="67"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="307"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="413" mass="47309" checksum="11E96F511EDA8648" modified="2011-10-19" version="1">MVVTLRRLFVVGRKMMTRKMQLWMMVCFLLMGVVRAMVSRGPKGRPYAEGSDFNGDYYDYLCNVFQATAELWEASKKSNKVPNPELQSALDKALFGNYGKRDLQEIKETLPEDYKQLRNRKEWCGSCKNSERYYPGRSITHDLMCLCAPGYYGEPFYVYYWSFGWYYEETGYKLCRKGRADMVNTQYEGWYAYKGYGQNKGLEKSWKTVVWECLNNRKDKGGEGSQNIKEKLEKLNRTILKFTGILRHANGRHKLGGYDDHYTASDGSDEKRIHVHYDTCDQLKKPWWKKLKEALQGKTETQLLVDSSTVTKTQEPLAPPPEEKGDTMLTAGDDVPIPPPGHEDPTGDPITPEEEGNGTLLMTQRAGLSTNSTDTTGSGIQNMEENYGANFQYLRSSTHINQPLWIFSASFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ9</accession>
    <name>F9WEQ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002053">
        <property type="protein sequence ID" value="CCD15775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07860"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="429" mass="48734" checksum="3286E83DC90E69B8" modified="2011-10-19" version="1">MARRGVRRTRDEMEEEAVAPVEQAEAAARDQVTAAVGPAISGDGLMQLMAMLTEMKQEMGAMKQEMNAMNNRMDAMNNRMDAMRQELKEEIKGVSEEVMKLEVRVEALANKGIKVVDGAYDAVYYAEWRLVVRSDEYGEGKLGMGVLDATSGKQPDLWCEKQADALYDPAEPWEGDVVPGVEGKLVMAVLSSVKGWPYMLFDEKVVQEEKAESLAGYNAVCDAYIRRSNLRVWNIMKRGLDKWFVSRLSEYPSSFTVIGTPGIGKSFATGSLLLYQMLHYPSENLKVVAYFMKERAYIFHREDRRVVFYKKEEVAVDEIEEMVSKGVEGYIIYDMGGGHNSIHSLPDKWGAVLLTSPKSSNYERWSADRLGETLPIYVDCYEYAEFKAVLIWERKKLGSDSLRLRKRPSTILEDWEVLRNRIYKVGPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WET1</accession>
    <name>F9WET1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002060">
        <property type="protein sequence ID" value="CCD15797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08080"/>
    <dbReference type="OMA" id="HIPPAQM"/>
    <dbReference type="OrthoDB" id="1454234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18340" checksum="FA981C3592C2CC9A" modified="2011-10-19" version="1">MSQQVQYYTTQQQQPQMGQLEQDPDLLRNLMVNYIPTTVDEVQLRQLFERFGPIESVKIVCDRETRQSRGYGFVKFQSAASAQQAIASLNGFVILNKRLKVALAASGHQRGRNNMNNGFGAYGGYGGYGGYSPYPSVANPYAQQQMMAMQQHYMMAAPPMPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF15</accession>
    <name>F9WF15_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08750"/>
    <dbReference type="OrthoDB" id="1729179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16218" checksum="0CCDCD4487328191" modified="2011-10-19" version="1">MRRCHLPGGAAAVVSGVRSGFAGGSAVGSLLRAAIGSRAHWFGSRRVSTFPARPRSTSTQSVPVPSQEKRSLTRSAPRTKRPTRSALQESYCMHGVCAWELPFPAGNLRCFQIANFVYWGHVALLRTRSAFSSTALSTKIVRATGNVRGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF23</accession>
    <name>F9WF23_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 339</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_08830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002091">
        <property type="protein sequence ID" value="CCD15889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08830"/>
    <dbReference type="OrthoDB" id="1066795at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017537">
        <property type="entry name" value="Peptidase_M42_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03106">
        <property type="entry name" value="trio_M42_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="385" mass="42099" checksum="572A7928EBD600B8" modified="2011-10-19" version="1">MTNIAIDQNYLLEKLGALLAISSPTGFTDEAVHYVARELERLGLEVMLTRRGAIRARRNGKSRKPARGIVSHLDTLGAQVKYLKSNGRLELVSIGNWSARFAEGARVSIFSSKGTYRGSILPLKASGHTFNDEVDTLPIGWTYIELRVDALARNREDLIELGIDVGDIVAVDPMPEFIDNGFIVSRHLDDKAGVAIMLASLEAMQRLKVETPVDTYWLFTIGEEVGVGASAVVVPDIASLVAIDNGTTAPGQNSSEFGVTLAMADQTGPFDYHLTKKLYELCGEHEIPVQKDVFRYYRSDAASAVEAGHDVRTALLTFGVDASHGYERIHLSALTSIAKLTVHYAMSDVEIKRDAEETAKGIKGFTHQKSTTAEQDLKPHDTPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU6</accession>
    <name>F9WFU6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_11250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002186">
        <property type="protein sequence ID" value="CCD16176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VALEDQW"/>
    <dbReference type="OrthoDB" id="292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="SSF49758"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="451"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1662" mass="187150" checksum="78DC0F73AC1D00A1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG18</accession>
    <name>F9WG18_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 451</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_11960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002215">
        <property type="protein sequence ID" value="CCD16248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11960"/>
    <dbReference type="OMA" id="QMSASYS"/>
    <dbReference type="OrthoDB" id="1062377at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="3">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="37683" checksum="0F03CA60D5757E4A" modified="2011-10-19" version="1">MFKVRLPGFASIDAGGPYRDILSQLASEIMTVHPSGEFQQNPVFKDYGSDGQLAVMPNVAWSTDSQSASVFAFFGKLLAACFVSKDLLTVEFPPLFWKLLLGEETTVRDLRVVDRDITRQLAPEELMKRSPEELEERFPGICESWRQLCDESSRLESCAELPPTSPYVAGALAAHITSHEIRRYSLAMACIQQGFGEVIPLYTLHAFRWQQVEHIICGTPELSYEGLCGVCEVSLPPEHAEMFNEVVQSMSDKDRRLLLRFTTGQTRLPLKKNIKVEQSDAALDTLPKSSTCFFTLYLPVYSSVTIMRKRMLYAIRHCEAIDGDGEAEEPIILNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG57</accession>
    <name>F9WG57_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_12310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002234">
        <property type="protein sequence ID" value="CCD16291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12310"/>
    <dbReference type="OrthoDB" id="1673120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389098" evidence="5">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="46"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="38286" checksum="4CAA4DF5C9D172E1" modified="2011-10-19" version="1">MIMIKCLIALVMCLVVRAHEEVKKDYNHEAHNALCDLMRAAVGKWEKRQEGLSDKLKKALGRTLFGNEEGGDITELKRKLPDYYEAVLKGNAARRTPCGGSESDQSAPYDMVCLCTLGDGGWPLNGIQTETTLCGQPKTALGGGVEGWSDERLSDEDWSDEERNKGEKELNATWGNVVTPCLESNLGKDLKEALEQFKGKLVNKSDDYFPGMYQLGEGEPDKNGACTGSKKYGVCVMYNNGTKTMDHRPWWVDLEKAIPQEETFQEEKRRKEEERRKQQEKSEGIDEPRAEPLTSRLPNTNQTQRSDTESSNTQFHRLNMTSGTLITPPCTWLLRALLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG67</accession>
    <name>F9WG67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002237">
        <property type="protein sequence ID" value="CCD16301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12410"/>
    <dbReference type="OMA" id="PRWYSRS"/>
    <dbReference type="OrthoDB" id="427637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389102" evidence="1">
        <location>
            <begin position="25"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="PINc" evidence="2">
        <location>
            <begin position="354"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="565" mass="62853" checksum="48326667654FBA57" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGL5</accession>
    <name>F9WGL5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002286">
        <property type="protein sequence ID" value="CCD16452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="WLDICRT"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112286" checksum="B38BF8D621F24363" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGM0</accession>
    <name>F9WGM0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_13780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002288">
        <property type="protein sequence ID" value="CCD16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13780"/>
    <dbReference type="OMA" id="WCCERPV"/>
    <dbReference type="OrthoDB" id="1078965at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395034" evidence="3">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="25552" checksum="59EBA8FF43261D11" modified="2011-10-19" version="1" fragment="single">MNKLETGLWGLLSVVLLLLLPGLALSESRCTRRPIYSQSECLAMPECLWCCERPVGDQCFDSTQPFTDLPCSAAAVVSNVNVTCGSLCSAPIGDCESCERRNWCYYCLTNTKCQSPYDDCPDGQVIQQCSMRDRSMWALLAFALPFLAVGALLLLSSCIFYVVLVVMDIREEHSQTENQENEHTPLLGEENPPEEDHQHQDVVNGSDNDNRNEDAVHPRAPDGEGEEASGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN8</accession>
    <name>F9WGN8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 524</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13940"/>
    <dbReference type="OMA" id="LTQRIWA"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="90"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="499" mass="52704" checksum="14359E12CB2AEB5F" modified="2011-10-19" version="1">MPLLPSFSHPFPQPQWRKAQHTQEGRKAMDLRVEPAAGPEEGSLPTGAVTGTPGAQGEELKPGGGQHHGDAKEGGTRTLASCITTLIPPGGMVSTVFNLSSICIGAGILGLPAAANSGGLIMAFIYPLIIVLVSVQSLYCIAAQVEKHSLKSYEGMARVLLGPRAAYAAGMLRVLNSFGACVAFVISVADILVAILQNSDAPDFLKSVTGNRLLTLGVWLCCMLPLVIPRQVDSLRYISTVGIIFCFYLMGVIVVHSCTNGLPENIKKIHLSGGPSDDGIHLFGTGNKAIEAPAVFTFAFLCQAASIEVYSSMAQPSVTRFTLYSAYAMAMCFVLYVTTAFFGYLDFGSKVTGSVLPMYDPVSQPAIMIGYIGLVVKLCASYAILMFACRNGIYNVIGRNPDTVVSWEHCLVAVVLSTITLVCGLFIPNINTVFGFVGAVSGGFLAFIFPALFMMYGGGFTLQKVGPLCYTATYALLISGVVLSVFGTVATIYGVATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGV5</accession>
    <name>F9WGV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 556</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002333">
        <property type="protein sequence ID" value="CCD16543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14570"/>
    <dbReference type="OrthoDB" id="1372685at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="252" mass="28033" checksum="D6BEC4EEF81073C7" modified="2011-10-19" version="1">MRFAVLGSGSQGNGTLVAHDDTYVLVDCGFSLRETERRLLRLGVHPTQLSAILVTHEHADHVHGVGLLSRRYNLPVYLSRGTLRGMRKPIEPAGFLAGGEQLQIGALSINVVAVAHDAQEPTQYVFSDGQRRFGVLTDLGSYCARVLDGYRDLDALMIESNHCRDLLARGHYPYFLKQRVGGELGHLNNHQAAYLVYELGWQDLQHLVLAHLSSKNNLPTLARQCFVDTLGCDPDWLQLADQDSGLDWRHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH04</accession>
    <name>F9WH04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15030</name>
        <name evidence="1" type="ORF">TCIL3000_0_46760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001348">
        <property type="protein sequence ID" value="CCD13992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002357">
        <property type="protein sequence ID" value="CCD16593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15030"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46760"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20135" checksum="EC7B6E7A5369EBAB" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKGIGDPEKINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH28</accession>
    <name>F9WH28_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002364">
        <property type="protein sequence ID" value="CCD16617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="RIVKHEM"/>
    <dbReference type="OrthoDB" id="1654537at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="842" mass="95687" checksum="A85C60CD7E590722" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHE2</accession>
    <name>F9WHE2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002418">
        <property type="protein sequence ID" value="CCD16735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16400"/>
    <dbReference type="OrthoDB" id="1697580at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390394" evidence="1">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="26564" checksum="353B9F3F9DA054BE" modified="2011-10-19" version="1">MMKLFMVMVVVLFVCASANEKHVPLSAVYLFFPIPISPFPENSIEIPMSYYTITSPRTIPWSMEKDVVEVLLDGVASADRINLYWFLRPVLACLPVDLVCFTLGDFIRNPRHCIPENNVCDALWQYLPYILWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPCQEVVLVEATPAFIQVPYSTVGYLVHIPLSTQPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR6</accession>
    <name>F9WHR6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 687</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002478">
        <property type="protein sequence ID" value="CCD16860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17450"/>
    <dbReference type="OrthoDB" id="1671874at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="381" mass="41215" checksum="683D95B02D43995C" modified="2011-10-19" version="1">MTLSEVISGFVKMTLFEVISGFVKMTLFEVISGFVKITLSVVILGYVKMTLSEVISGYVKITLFEVISGCVKITLSVVILGYVKMTLSEVISGYVKITLFEVISGFVKIPLSEVIPGFVKITLVEVISGFVKITLSEVIPGFGKMTLSEVISGYVKMTLSEVISGYVKITLFEVISGFVKMTLSEVISGCVKITLSAVILGYVKMTLSEVISGFVKITLSDVISGFVKITLSEVISGFVRITLSAVISGFVRMALSEVISGYLNMTLFEVISGFVKMTLSAVISGYLKITLSAVISGFVRITLSEVLSGFVRITLFEVISGFVRITLFEVISGFVRITLFEVISGFVRITPSEVISGEERGYVSAERSLVVDYCGSLITDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS5</accession>
    <name>F9WHS5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002481">
        <property type="protein sequence ID" value="CCD16869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17540"/>
    <dbReference type="OrthoDB" id="1719354at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="37655" checksum="435C363B20DC1F8C" modified="2011-10-19" version="1">MQPQKKSGPLQQYHAVDLIRSLRRGKAVTHNNESERKEEKMTETIPTRTTEEKESIHEDKQKTRQNKDSTSNRINEKIGADQKQQEESTEQSRDTNNVDRKDKAADNNIRKIAKEPLEANSSTKNIMKSAVEQNSVRPIIEKRRHLKHMGRLQPRVPKFVDPQIILDDAVEVADNADPEVTAANAVEVADNADPEVTVAEAVEAADNADPEVTVAEAVEAADNADPEVTVAEAVEVADNADPEVTVAEAVEAADNADPEVTVADAVEVADNADPEVTVAEAVEAADNADPEVTVADAVEVADNADPEVTVAEAVEVADNADPEVTVAEAVDAEGNMPVKSVMSVLQSVGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI38</accession>
    <name>F9WI38_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_18520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002524">
        <property type="protein sequence ID" value="CCD16983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18520"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390370" evidence="5">
        <location>
            <begin position="23"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="81"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="402" mass="45951" checksum="377CEA80D248180A" modified="2011-10-19" version="1">MLRRGVALFFLFFWVRMPACQGAKENAGEAELFCRIRLLAENDPEKLVFENEEREKQIMRQIEKVGPEIRTLVGKADQRDASLIMQFNHLVKEAKTIMENMRDLRRKAGEKRVSAKRHLHQVIFGDYGGEGKGELDAKPETIQKIFSAVTFTESCGGQGDKPAGKSLINDFICLCASNTGFDAHFNSHEDRSICMYGVTTTVEPNFKNWTEVWHWNKHRICINTAPPIPTPQNINYLVAHFTRFLEREQEKFQVKNVFGFLNITNNTAKICDGTKFGTICVNYEHALKNGGIEWVNHLKKASKDLEDMSRFAEESESTLPQLELLEYNALLLYEEAKYSTHLPHAVPSNETDTNSSNESYQGASPNASEEDKVEEEDIEENKESTWKGGPPLWGFVFFLMFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI94</accession>
    <name>F9WI94_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_18980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002549">
        <property type="protein sequence ID" value="CCD17039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18980"/>
    <dbReference type="OrthoDB" id="405234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="377" mass="44587" checksum="A4A470399C4AD68F" modified="2011-10-19" version="1">MVKNVRMRFMQRTRRRNGRVLLCVEIMLFIIMLCVLWITCVDQPNTAIGKDSLTPINYDTYFRFIPPDVVRTWKAREFLVVMGIPSIDIDARQRRRHLQRETCWQYDEVARQRNNFTGELLPLYLLAPHQDNGYEISGSLWKEATKSHDVILLPTCDVRPTTRKRMGENGTWGLEPEVVMSRKTYLWFQFALHMFPNAPYLVKGDDDMFMRVPQYLADLRVMPWRGLYMGRMFRARFLWKHDDIFFATGACFTLSNDVAQAFVSYKPLAALLSKPYSIWRIMQYFSMSANHEDIMVGRVLQEKLKLEGLITVNVGRCRFHGSRMRGLFTIVTQKSVVVHRIQEEDYQRLWKWFDDHQKSQVPTQLHWFSKTSAMLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIC6</accession>
    <name>F9WIC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 767</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_19260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002567">
        <property type="protein sequence ID" value="CCD17073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19260"/>
    <dbReference type="OMA" id="TCVAYQL"/>
    <dbReference type="OrthoDB" id="330091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="622" mass="70092" checksum="7EC999EB13B402AC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF9</accession>
    <name>F9WIF9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19580"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395077" evidence="5">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44495" checksum="4C0BB016C418AB0C" modified="2011-10-19" version="1">MNKNLATLLVLWLGSGAWWGMESPVPRVSARNKVAGKLLCEAFRAANALRNSVNVSQNLKNEIKLAVYGAPDRVQFDEGGNFRHSSLFRYGTQYPREKVCEYYGNNRGRGQVDGIFAESLFGAFVCVCAPPITNRYETLCGVRHWERRRAWSGNFNWGGRHHSLLQDVWDEVISKCKAGVNNHESHLTRLGNLAKALTAIRNELRWHRASGGDVHILGDTRDIRGCSGKAGKEVCAAYKYEAWKRGVPWIQSLWHVLHQLYAEYEKAVGPRITVTVPQPSPQTSGTHGNPGTSWTSQESQPYQPHQPREVLVDEQGHTIVLDDDTFPEDLPNSTEAGWEAEENETSNPVQGPIPNPTSDLDPTSPEAAEGIVAHLTAAAHEGGASITPACAWRLFTATVALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIG5</accession>
    <name>F9WIG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19640"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394794" evidence="5">
        <location>
            <begin position="17"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="39"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34299" checksum="33B89BF79CCC88AE" modified="2011-10-19" version="1">MMKLFMVCLVVVCVCASEDKKNHNGDHHATLCGLLGTAAHKWKTTNHPGVKKALSQAIFGHTQGGDIEKHSQVLPSDYHQSGNRENWCWHCKNYETHHPGKSIPHDLLCLCTVGSKGHEYSDRTSSLCGRNGVVLNVVHGWSSSNSGVEHLKDAWEKIVKPCLQNGPRVNIDQAVANFSSSMENRDTPNWSASHTGNCKGDSGHSSICVGYDGWCLHGNDYHLWWKDFVWALRAPNLTEDQLNSTTFLNATRDTADSSQTGQQGSSTQAMPSTTSASSTTEESPGKVLPLLSNQQSSASLTHPLLCLLSASFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS9</accession>
    <name>F9WIS9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002634">
        <property type="protein sequence ID" value="CCD17227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="909507at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="68713" checksum="683FF0AC8E24B008" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW9</accession>
    <name>F9WIW9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 841</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_21010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002649">
        <property type="protein sequence ID" value="CCD17268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21010"/>
    <dbReference type="OMA" id="YASMIPT"/>
    <dbReference type="OrthoDB" id="1151754at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="PTHR12768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APG6" evidence="4">
        <location>
            <begin position="649"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="837" mass="91010" checksum="AC53410763C2D034" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ33</accession>
    <name>F9WJ33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002676">
        <property type="protein sequence ID" value="CCD17334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14915" checksum="B5110E093B5D567F" modified="2011-10-19" version="1">MHALGGGNGMGRGSYGARSKGLPHQRSNRMDYCVKVFHVTATGHRPACSTRDSLPLLFITCGGGLLLCGAWLAAHFAQHVRYPHVLCRIHYISDCVRHPCRAASRSHARSVRAPRRIRKDKRRREENGKFARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ52</accession>
    <name>F9WJ52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002684">
        <property type="protein sequence ID" value="CCD17355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="121" mass="12833" checksum="18CAB51A4F9D7FAE" modified="2011-10-19" version="1">MLKNVVAGTTPQSSRALSKMASTVLSMVHLLPPCEFKVSFSILKPYYALKLEKKNKIGLGKRIVSRGANFSGSSCGKYEGQCGFSYGIRAEGAAGPFLQALSKGVVDAKGTTHTAACVRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ57</accession>
    <name>F9WJ57_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002684">
        <property type="protein sequence ID" value="CCD17360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21860"/>
    <dbReference type="OrthoDB" id="1701027at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21323" checksum="F7F236B8D5008840" modified="2011-10-19" version="1">MSWYTITSPRTIPWSMEKDVADVLLEGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPESNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRSPPHVPQYQPYQGVVLVEATPAFIQVPYSTVGYLVHIPVTPGSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ88</accession>
    <name>F9WJ88_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 88</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_02440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002698">
        <property type="protein sequence ID" value="CCD17392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02440"/>
    <dbReference type="OMA" id="TPPCEKQ"/>
    <dbReference type="OrthoDB" id="1275249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="PTHR23291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="19216" checksum="347B1257B5E2FB51" modified="2011-10-19" version="1">MFATPLCKTIPFWLPMAAGFVPLLWLSYAPPQNPTLKMGLFFSFTVLEGMALAPLIASSMVKGVLGTAVVLTGAVFCGFSAGAYLAPRASLLALQGPLFGMLLGMVAISVLNIFYPTAFAHSIILYGGLALFSLMVSVDTQAMIERARCGAGDVVQDAMQMFLNVVNIFVRIAQILGSGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB2</accession>
    <name>F9WJB2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 892</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_22370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002705">
        <property type="protein sequence ID" value="CCD17416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22370"/>
    <dbReference type="OMA" id="ISANCRC"/>
    <dbReference type="OrthoDB" id="598676at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="FAD_binding_2" evidence="5">
        <location>
            <begin position="84"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="817" mass="87090" checksum="FC038EE44A00C283" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJF9</accession>
    <name>F9WJF9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">WGS project CAEQ00000000 data, annotated contig 905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TCIL3000_0_22830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002719">
        <property type="protein sequence ID" value="CCD17464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22830"/>
    <dbReference type="OrthoDB" id="402798at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="PTHR12604:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Ku" evidence="13">
        <location>
            <begin position="447"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD17464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="802" mass="88062" checksum="EAE08DFA0113CF19" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJJ3</accession>
    <name>F9WJJ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 917</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002733">
        <property type="protein sequence ID" value="CCD17498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23150"/>
    <dbReference type="OMA" id="AIVMPAM"/>
    <dbReference type="OrthoDB" id="1449637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30173" checksum="9A08A38EB863CDF9" modified="2011-10-19" version="1">MIHKPQQRKGCEYGSVTRVCNWFTAVIAFFKVFFVPPLPSICCFSPPHSSLTCYFRRRIFVAMSRQSGQQRAMNALGNQFTCAVILSSAARHFSNDANNFWLLLQTDDGALSPETIVESIHRFCIAHDMKFVDCGSDAATLVHEREAHVALVRCSDATEITQQLLQLGGNPSVITLEIFYSEATTWNPANVMPSDEWQWLRPTPSCLAEMRHSSSGTCGTVASLPATMRCAKPVIRAQLPALGPGSVPWSAAVTLEGMMREVGYKVGCLSKYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJL1</accession>
    <name>F9WJL1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 925</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002741">
        <property type="protein sequence ID" value="CCD17516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23330"/>
    <dbReference type="OrthoDB" id="803584at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="268" mass="30227" checksum="A110FD34C4F12FFD" modified="2011-10-19" version="1" fragment="single">MRATTPPLYYERREGAPVPYHTSLAPTPAAPTLRLPAHTSAWQTYAQPLGTTQIGVGDGAAQPLAGGDFRFSVSSTSSASALGLPGVQSRQNGTVDSLAASGALRQSSTYMRDSANHATAHFVAMETRELSLMAEEVKLSDQVRDLEDKRNQLYEATTHLNTLWNDLLERERRYFMEPVVDLSEQMRELHLERQNLEAKLSYQEDCLRAVQRELQQWDYVVKEKESLEQEVSRVREQLMAIERRRKVCKGKAECLFEVESKRAECGXP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ1</accession>
    <name>F9WJQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_02510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002753">
        <property type="protein sequence ID" value="CCD17558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02510"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389229" evidence="5">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="31"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="38914" checksum="D28560A82691F4B4" modified="2011-10-19" version="1">MLRSLLFLAFLMNTWSAANDYNKDVFDKLCEIKKKTMALFNAHQDHSQINKSLYEAIYGSEESARFDDNGDVKFGGACSLTAHGRSEVCNYKTGNSGSSGKNGCFADSLFGTFLCLCTPGSGDAGTLCGFGKVGDGAVWSGFAGVGHEKVLFSKVLEKVKEQCTGELPNVLNNDNKLNNLITAIEAVTGRLKEIGGYLYLGDGRGVCSGINRNEVCVAYKKVSGKNEADIPWVKRIYKVLEDLQKVIHQRTEHKNSKTEPKTYSQLGNSVENVDHKENSDNITDKNDEKSEDTEEKTNTVKSQSISREDLQRRKRRIQKSTETNIASLATDTNEDGSIQTNPKWPFLTTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ9</accession>
    <name>F9WJQ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002755">
        <property type="protein sequence ID" value="CCD17567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="16082" checksum="5AD5C2DF91DAAB28" modified="2011-10-19" version="1">MVLTCLQLRCLPTHTRLARELLLLLFWEEKYIITVIFISPLLCLRLMLLLLLLFFMSITFLIYLFISACTKHILFRAFSHFLHLLLLLLLVVACVLVAVGVTRAHFFYFPLTFGRSSLRWSSSQRTNFCIGTPPSQSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJS4</accession>
    <name>F9WJS4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_23940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01002762">
        <property type="protein sequence ID" value="CCD17582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23940"/>
    <dbReference type="OMA" id="PYIAYND"/>
    <dbReference type="OrthoDB" id="1383773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PMSR" evidence="5">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="20106" checksum="068D757811AD7C67" modified="2011-10-19" version="1">MSNGIPATFAAGCFWGTEHYFKKFFGAALLSHRVGFMGGTELPEVSYELVKGGQSGHAEVLHLTYSPDKVAYRDLLEYFFRIHNSTTLNRQGNDVGSQYRSAIFYHNDEQKREAEHYIEGLNGADGELHKLIVNAFGPEARVVTTVESASRFYPAEEYHQNYLELNPAGYCVHRLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJV2</accession>
    <name>F9WJV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002777">
        <property type="protein sequence ID" value="CCD17610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="17036" checksum="D12F2B5BE6E824B9" modified="2011-10-19" version="1">MTLLGEREGTERIMKWRAGRRFDEMRGFNFHESRLAPLNNFHAHPLGTRREWHIIFISREKLAPLLFLPPLLAFFLFLFFFCVRYSFYYAALFIPLDLFFIYCHAFLFFFSPYHCTALCCRAPSHIPSCWRAVVYICSFKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK77</accession>
    <name>F9WK77_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002820">
        <property type="protein sequence ID" value="CCD17738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25220"/>
    <dbReference type="OrthoDB" id="1670821at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="318" mass="36082" checksum="E5A9B45416A58588" modified="2011-10-19" version="1">MGILEQRRIINGIMVMVVSVAMECVWAGFTDYKKGHNFNGHEHDALCEVFKATADLWETSTTSKKKLGNDLENALRQALFGNTRTMHLGSITSTMPSVHHNIGHRGWRCGSCANGDAYSPGSSIPHDLMCLCTPGYYSEPFYAWWWDLWWHYEETKFLLCGKKREDMVSDQYQGWYVDKGTKVAKGLDKPWKAVVWGCFDNRNKGSGTGNPDLEEKVKKLKTTMQKFTTLLKVVGLHHKLGGTMNHTASDGRTEENIHVHYTDCAGRSEPWWKKLNRTLTKKKDSSSKAPHGVPSYPREIKATQDLNTNSTEDKFSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W359</accession>
    <name>F9W359_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1004</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000356">
        <property type="protein sequence ID" value="CCD11567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25400"/>
    <dbReference type="OrthoDB" id="1347446at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22261" checksum="B455344FA55A2898" modified="2011-10-19" version="1" fragment="single">MEAKGEAVSWRPTVAGATCECTRASSPTGTSMETTTSHDYRSHSHREPGVWAPCVAGTRTGCCCAHGTRRAPQADDRVPSYEAQHYKDWASPAEVMQLRAICTDIANKHKNETAALRNELKEMQSSRDALMLEVEGARRLHEACVKAESEHEKARREYSRWEEEREVLRLQLQRLTLENQQLRRGASHSGRDRGPFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D3</accession>
    <name>F9W3D3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 1039</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_26090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000395">
        <property type="protein sequence ID" value="CCD11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26090"/>
    <dbReference type="OMA" id="MILSWWV"/>
    <dbReference type="OrthoDB" id="659967at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388622" evidence="8">
        <location>
            <begin position="25"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="44269" checksum="3E14FCED7BBDD05E" modified="2011-10-19" version="1">MKCSALALLPLHVLFGQLVALVNSFTGVSTTKLIINEASYPILQSLTAYSFIFTVYGPIFILIYHRHKHEKFRNFSFLWRPWKYIFLGLVDSQANFVIVKAFQYTDLVSAQLLTCFSIPCVLVLSYFILKTRYTFTHIAGCVIALGGLLLLVLLDADGVSRTESGPNVVKGDLLGIVAATLYAVSNVLTEYFIKPKAMRPQADLSSEHTAHQDEVMERPVASRDDDSSASVLCDNASDNARAHENEGRNVPALFPMIENVCCMSGFAVIITVIQFFALEWSTFSSRTRPWTSEDWIYQMLFGFTMLLVYTGIPALFLFKSATFANISLLATSVYGIIWNVTIFHVYPTPIFFAAFLLIITGVLIYAFSDLHWSWCPEKNYPCGVRAAVEGGVEAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X9</accession>
    <name>F9W3X9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000492">
        <property type="protein sequence ID" value="CCD11857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13450" checksum="5C28252FAE725773" modified="2011-10-19" version="1">MEGFTLFFSGGDFFNYPIWARLLLPFVDRPLWRSSSAPLSYVVHHCVLRAVPVCLCQSIRLKALTKECAGFCGTVILFQQSIPHHVLYVVLLVIGDVKRSMEKSLSCTYPLHVVRCFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W406</accession>
    <name>F9W406_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_28270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000500">
        <property type="protein sequence ID" value="CCD11889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28270"/>
    <dbReference type="OMA" id="MERNLGN"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="7">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="447" mass="48096" checksum="BA0B9189D6F9DADB" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGKAPPAVDWRKKGAVTPVKDQGACGSCWAFSAIGNIEGQWKVAGHELTSLSEQMLVSCDTTDYGCRGGLMDKSLQWIVSSNKGNVFTAQSYPYASGGGKMPPCNKSGKVVGAKISGHINLPKDENAIAEWLAKNGPVAIAVDATSFLGYKGGVLTSCISKGLDHDVLLVGYDDTSKPPYWIIKNSWSKGWGEEGYIRIEKGTNQCLMKNYARSAVVSGPPPPPPPPASTFTQEFCEGAECQSGCTKATFPTGKCVQFGGAGSVIASCGSNNLTQIVYPLSSSCSGFSIPLTVPLDKCLPIVVGSVMYECSGKAPTESARLVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W457</accession>
    <name>F9W457_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_28780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000517">
        <property type="protein sequence ID" value="CCD11941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28780"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
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        </location>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="332" mass="36430" checksum="8CC8A55BAD1165CF" modified="2011-10-19" version="1">MAGEVNALLKLQRGNPEVRQNLDEVIYGKHSRARFDNDGKVEPTWKCGVPQNGRSVLCHHHKRGSGWDGCFSESLVGTIICICTPGKKGNSIASLCGANITQYRGTWWGSTHTLEDKKSLFKEVWNTTIQKCLVESKSNRHGARGWERLEKSLTEIKNNLTPGKIGKITYLGGNAAGSCIGIDETDVCVAYPGKGKDNVKIPWLEKIEETVRKFHQRVTEKHLTPAPAETGPAEPSAAPMLAAEIADQAIQPQNAPHVADGQPENEELETETSESTKSSEEAPKSRRKRSTTTTPNPSPTDTPHIPHIATDPTEDGSLLTLQKWLLLTVIFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
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    <name>F9W487_TRYCI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000530">
        <property type="protein sequence ID" value="CCD11975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="14061" checksum="C83AB080036039E0" modified="2011-10-19" version="1">MVTVGHPAAPEHWPLLDNIRCMRGYGRGDDCSCRPPQSFICVEQSQLEEFRDPRDMHICRRSRGLMECAGALNEAIPRGIPIAAKKAMLMGMGAAPQKWTSEPTELDKIIQECVGKMRKRPTLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H3</accession>
    <name>F9W4H3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1182</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000555">
        <property type="protein sequence ID" value="CCD12065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29840"/>
    <dbReference type="OMA" id="SKVPHEA"/>
    <dbReference type="OrthoDB" id="1617433at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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            <end position="413"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="431"/>
        </location>
    </feature>
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        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
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        </location>
    </feature>
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            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="624"/>
        </location>
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            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="969"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123923" checksum="44A9D09C033D5D48" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4M6</accession>
    <name>F9W4M6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_30340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000579">
        <property type="protein sequence ID" value="CCD12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30340"/>
    <dbReference type="OrthoDB" id="1670373at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388662" evidence="5">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="39190" checksum="D154DFCE8BE9DB52" modified="2011-10-19" version="1">MRMRVWMVVCMEVMVTMGVYGNEKNHNGDEHDRLCKVLSAAVTALQTNSLSNTLKEALYITIFGNKSGGSLDALKGSLPVDYNDEKGKSRANVCGQPPNVGSRDHQQPRWPGHSAPHDLVCLCTPGNDGWPFGESIPGKKKLCGREKSALEIAEGNKGWSSSGNGEEGKKQMQETWNTIAKKCLGGDAGGNDLKEALHDFLRNLHKQSFDKYQERYRLGEDKEDPYPCSGNKKICVMYYNTTEANYPMPWWTELQMAIKNDDELQPKKKREEEINKQENSQKQRQTQKQDQTQLPHTHRTAALQSAQQGSQEAEPDNTENNPNPIATLEETSGTLIIPPSSWLFNALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R1</accession>
    <name>F9W4R1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000593">
        <property type="protein sequence ID" value="CCD12156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17167" checksum="8ECC9ED8F0CBA86B" modified="2011-10-19" version="1">MLKKNHVSHASVQFPYRFNAVAPNPQLRASSRYMHVCPYLCIWWKLLLLRKPANITKCSVLFRGPIYRHAAFGVATVSLKMYALNNADSLGGNVNRWCGVVRHNTIIKCSSFCSTSLQQKLLEREKKKKLRCYTLWDHMLMHLDPQCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W530</accession>
    <name>F9W530_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_31740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000650">
        <property type="protein sequence ID" value="CCD12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31740"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="884"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1225" mass="134995" checksum="1B1074D9B1FE8F99" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W559</accession>
    <name>F9W559_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000662">
        <property type="protein sequence ID" value="CCD12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32000"/>
    <dbReference type="OrthoDB" id="1704120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21009" checksum="17E1827A5D2A519B" modified="2011-10-19" version="1">MLQCAPHLMERPVAPSGEKTRSTSLALSCVARSPGLNVTGTCMRRQAFPSHVFKNLGTKQGSVSATFGPTVSHELTDTYSASRKLSVVKVVILGYWHIETHASQEEVTLFQGIRDGASASTSSFADYSVLSSLGCATTSFSSRITVFFGISSIHGIAEWSCTHTNLAAVPHIPFANALVFCTHFSRIGNKRRVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>F9W570</accession>
    <name>F9W570_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_32110</name>
        <name evidence="8" type="ORF">TCIL3000_5_480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000667">
        <property type="protein sequence ID" value="CCD12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32110"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_480"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="1097975at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030509">
        <property type="entry name" value="CK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909:SF409">
        <property type="entry name" value="PTHR11909:SF409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCC90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="326" mass="37569" checksum="C4966B3F236DF05A" modified="2011-10-19" version="1">MSVELRVGNRFRIGQKIGSGSFGEIFRGTNIQTGDPVAIKLEQVKTRHPQLAYEARFYRVLNAGGNVVGIPNVLYHGVEGEFNVMVIDLLGPSLEDLFSFCGRRLSLKTTLMLAEQMIARIEFVHSKSIIHRDIKPDNFLMGTGKKGHHVYIIDFGLAKKFRDSRTHQHIPYKEGKSLTGTARYCSINTHIGIEQSRRDDLEGIGYILMYFLRGSLPWQGLKAHTKQEKYARISDRKQTTSVETLCRGFPPEFAAYLNYTRSLHFEDKPDYSYLKRLFRELFVREGYHVDYVFDWTLKRIHDTLQEGNADQQPQRRGSEKEEENTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W576</accession>
    <name>F9W576_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000668">
        <property type="protein sequence ID" value="CCD12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32170"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388692" evidence="1">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="48149" checksum="ED6EB35EB02F83AF" modified="2011-10-19" version="1">MCDRYIFLVVVMLVGVVMVEARDLPALKLESAQGACAVSRLMKSMYNFVSSRNKEAQEMYESVERMYDLGRVRIAQHVLENGECDRMTFFVLFSQRIKENMTRKIRELASAGVRLVGAAGLAAGRLDEFINIFRHSWHVQTTHIYSTTYNHTYSFCLRGKGTKPVDKKSIVDCFMNDKETDDNGFVPVDGGDVHWLDQDDMGSLLDMRLKLVDGDPRDEHGQDRSCMLLSMDGNDGYLGKGNKGKKVLWADGLLGVTSGHAKKSGFTGSVRSSSYSTNIMWEAKPSSSIPVLKDFVVRYNDYRKLFDEVKHLSAAMTDDWTVDHLMKYAEGIASLLYKPEELDVLLSVDENEDNETAEEDQRLLRLRHTVEPFVGLNDRKQEWLAQYNKELVSKEFLAAEIQLCRSAAELHLRRNRWFFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J7</accession>
    <name>F9W5J7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_33280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000720">
        <property type="protein sequence ID" value="CCD12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33280"/>
    <dbReference type="OMA" id="LAYEWIG"/>
    <dbReference type="OrthoDB" id="1318747at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="PTHR10984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="ERGIC_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="COPIIcoated_ERV" evidence="5">
        <location>
            <begin position="140"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="25413" checksum="2F57A91D96FA21D7" modified="2011-10-19" version="1" fragment="single">MKRFSRLDVFPKFDARFEQDARQRTALGGVLSIASMVAIALLIIGEVRYFLTTVEQHEMYVDPRIGGTMHVVINITFPRVPCDLMTADAIDAFGEYVEDMGRDTVKMRVDSDTLAPLGEARPLVNMNKKATSDTHDCPSCYGAEKNPGDCCHTCDDVRRAFAERQWEFHEDDVSIMQCAKERLQMAASTASREGCNLHSSFRVPRVTENIHFVPGRMFYFFWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5K5</accession>
    <name>F9W5K5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1337</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000726">
        <property type="protein sequence ID" value="CCD12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33360"/>
    <dbReference type="OrthoDB" id="1651489at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17055" checksum="B1E158D8B9035B6A" modified="2011-10-19" version="1">MGMETTENPTDHETQANGTLHQVQSQSPPRPNALPALMESLRPLDSVVAYLAKGPSLPCNSRKNFSWKEFKRNFYFPEDTLPAGVMNDKELRSILQELSTRTRPSCCACRPHASELQLVELLTGVKGEQSLTRTVREHLYEEPRGGTVLPHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Q3</accession>
    <name>F9W5Q3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000750">
        <property type="protein sequence ID" value="CCD12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GCEVASM"/>
    <dbReference type="OrthoDB" id="581771at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20845" checksum="AF5BA9BBBB25F7D0" modified="2011-10-19" version="1" fragment="single">MIHLSRTRFTRPACISHMPSTLPYFDVCVIGAGPAGIAAALRAVDYNKRVCLVEAKRIGGCDLWNGALQSKTLWEMSKYVSSLSGKAAQRVFDEATIGEIQRKLDLSRVRHALNEVSSVRETQTMELLRAAGVTTVFGKAMFSSPHELDVHSPSTNEYHVLTADYFIIATGSVPRQHEFVTVDHRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S7</accession>
    <name>F9W5S7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_34020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000762">
        <property type="protein sequence ID" value="CCD12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34020"/>
    <dbReference type="OrthoDB" id="1669094at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394704" evidence="9">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="41"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44200" checksum="0D49F92E2BFA1288" modified="2011-10-19" version="1">MVMHACTILLFVSCIIGVQSYGSSTPKKSTIVPIISLGNAKAACATSRELKRVYNYVTAAVREYESKYDEIVMIRDIARLKVLKGVSDYFECGRESSFLLYTHERLETMKAMLEKLMDVGIKAAGSAAIAAGRLDEFISIFKQAHGNPKSAAGKCPQMSGAGATSLKSLLGKCYDTSSDDDNEFYGIQDEKENEGTASTGRNDKDLGEFIFTTLSGGGDQQGNGAGGNSDWTCPLATVSSNSRYVKDKDIQKDVKWADGVFAVKKGHEGGVWAKNPTMVVPTLRNAANDFSEFRKVLRDLRGIYAGIIADWLKNKMKYDEDIKKTLAMLGQSEITPEETLFHSHMGIEDEKGPKWLSDWNEERMTSAVLKEELRLCEQKELSTYSIGLRGKLVTLAAAAGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W653</accession>
    <name>F9W653_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000823">
        <property type="protein sequence ID" value="CCD12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35170"/>
    <dbReference type="OrthoDB" id="1281266at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018154">
        <property type="entry name" value="TLV/ENV_coat_polyprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10424">
        <property type="entry name" value="PTHR10424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00429">
        <property type="entry name" value="TLV_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="18942" checksum="3E29053413607ECC" modified="2011-10-19" version="1">MTQLCWLCYASSPPYYEGIAQIRTYNITSDHSQCLWGENRKLTLAAVSGRGLCLGQVPQDKGHLCNQTQNIQSSKSGQYLVPPLDTVWACNTGLTPCVSMSVFNSSKDFCILVQLIPRLLYHDDSSFLDKFEHRVRWRREPITLTLAVLLGLGVAAGVGTGTAALIKTPPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6C1</accession>
    <name>F9W6C1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1446</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_15160</name>
        <name evidence="2" type="ORF">TCIL3000_0_35830</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000847">
        <property type="protein sequence ID" value="CCD12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002362">
        <property type="protein sequence ID" value="CCD16606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35830"/>
    <dbReference type="OMA" id="KVGEYQR"/>
    <dbReference type="OrthoDB" id="680824at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="PTHR23409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="39065" checksum="19015B296DCD094D" modified="2011-10-19" version="1">MPESGVKHPRDEEAAVQVAEEPLLKENPGRYVLFPIKYHDIWKMYKEAESSIWTVEEIDLGNDMVDWEKLDNGERHFIKHVLAFFAASDGIVLENLAQRFMSEVQVPEARCFYGFQIAIENVHSETYSVLIDTYITDTEEKNNLLNAISTIPCIKRKADWAIRWIGCDSSFATRLVAFAAVEGIFFSGSFCALFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYEKYIKHKLSREEILSIICDAVSIEREFICDALPVRLIGMNSDLMAQYIEFVADRLIVALGYERHYNVKNPFDFMEMISLQGKTNFFEKKVGEYQKAGVMSSDGSSKVFDLNADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y0</accession>
    <name>F9W6Y0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000945">
        <property type="protein sequence ID" value="CCD12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37580"/>
    <dbReference type="OMA" id="MRRYAQW"/>
    <dbReference type="OrthoDB" id="518407at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="587" mass="65347" checksum="B969D2DC847887D2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W779</accession>
    <name>F9W779_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000993">
        <property type="protein sequence ID" value="CCD13044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38600"/>
    <dbReference type="OMA" id="CTHERRM"/>
    <dbReference type="OrthoDB" id="1598979at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="13"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38413" checksum="082A3F1769C60005" modified="2011-10-19" version="1">MVIHARPSEKIVSAWRILGLHANPTYSEVRAAYRRLAVATHPDRSNEPGTKERFQKLHAAYEEAIENCKHMDISGDCGINGDIDGFDWRAAVARVRTEWRKRYGMEPDAMERPGKRQKEAEGTAKKSREQMSKAPRTGKMATAPLLASKKGAKSPTHSSTERNQKRAKSRRKLASNSHSKHRPDAAPPSGPKVAGGRMHHSTPSLKPPTSKGKSLAAPRNGAAAVGKQKKAAASSGSKSTSASPIREVRKHSQITVNRRRCLLTSNDKVLCRLMASEATRRLLVCTHERRMWRLIGQMIAETRLRCAIMQLEDAAWRSITGQLHHGPGWTHKCHKDICKIATRCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W792</accession>
    <name>F9W792_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001000">
        <property type="protein sequence ID" value="CCD13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1881652at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17984" checksum="BDD00FEE8CF07F55" modified="2011-10-19" version="1">MVVTKRGRRNFWGCPPGQAQEKKKPLPKSPEVPHGPFHIPLQAKQWKRKGFGGYNTPGSRAITYCRTNEACGRLTSQIGRDLGHSAKYGCTQRRPTEFCELPPGPSPRKKKNNNTSHRRCPTRLFTYHCKQNNGNEKVLEGTTPRVPAPSLIAVLTRPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7F9</accession>
    <name>F9W7F9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1603</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_39070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001023">
        <property type="protein sequence ID" value="CCD13125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39070"/>
    <dbReference type="OMA" id="HATHCPI"/>
    <dbReference type="OrthoDB" id="158628at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="889" mass="96842" checksum="EC72A8153A985FFF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7X8</accession>
    <name>F9W7X8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001100">
        <property type="protein sequence ID" value="CCD13300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="13307" checksum="B1487280C613168A" modified="2011-10-19" version="1">MGLRCFIHSSELCVVCLPEKCAWGCVFFIAAPINVPYRCVYRCQTKFCLPCILCVPLPFYSFRLSSILFSSFFLRSVRYMGGFFLKHCLLFVCLEAVLSVRGCGIHFLHFVENVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W844</accession>
    <name>F9W844_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1704</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001135">
        <property type="protein sequence ID" value="CCD13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41280"/>
    <dbReference type="OrthoDB" id="1209831at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003774">
        <property type="entry name" value="UPF0301"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30327">
        <property type="entry name" value="PTHR30327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02622">
        <property type="entry name" value="DUF179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="23984" checksum="16281592F0366B0A" modified="2011-10-19" version="1">MIVVRVTPNESAALVLNKPLENDKGMLMPVSMTMRLNNLHPLFCKHLCNHTVLIGGPVSRGTFDASVLLLHRIPDVDDAIPLSHSLWVDGNYDVLQQKIENGTADPKDIVVICGFSGWGVQQLEGELQSGTWVVVEGDTEDRALDNFVFTIARLAGAHPHGPASSSVENADGKQAPLSMEERNRQHRASLWSWAYSALGQPFASMALNQKPFTHGPQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W858</accession>
    <name>F9W858_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001139">
        <property type="protein sequence ID" value="CCD13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41420"/>
    <dbReference type="OMA" id="LVKNDAC"/>
    <dbReference type="OrthoDB" id="607952at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1198" mass="133811" checksum="4AAE4929C306F58E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B1</accession>
    <name>F9W8B1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1722</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001156">
        <property type="protein sequence ID" value="CCD13443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41920"/>
    <dbReference type="OrthoDB" id="1707087at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20373" checksum="5A28A67C0799006C" modified="2011-10-19" version="1">MQQCPTSTAEARHILDQFLKHLKTGGVYRWGEKNDKVDGSERKEGMLGTSVGKNGISESEKGPICNGKEGKIGQPPGGICVYHGKESNWETSIHWLKQFRVALETVCATNSQIATIKRNIEKLQTLLHRAEQIYETNKVISEVQKPVVPKDFQTTAKRLTAYNAAWSHHPHNHLILLFVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H9</accession>
    <name>F9W8H9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_42570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42570"/>
    <dbReference type="OMA" id="ATQELPW"/>
    <dbReference type="OrthoDB" id="688282at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="42145" checksum="E79945D71B976328" modified="2011-10-19" version="1">MKRGGLSLDATAVEKAQRDLQSYQIRNNNCLQLRAFLLNDTGMFTKDGRKILASVTKDDIDPTASRIIGRGASGTVHFSKLRDKTPVALKHIPITSKLHRDEVDRELSFFSSHSDSPFVMKNLGAFWDSEEGAIVIPMEWMAYTLKDMSYFWEGIEESILRDIFFQVVSGLVYLHDTKRVIHRDLKPSNLLIRDDGYVKISDFGVSKLVQTLDVSSTYVGTMYFMAPERLEQTSYSFSSDIWSLGLTVIATVTGKNPWAPPDEMNLFQLLGKIAGDTIPSLPERPAYSENARDFIRKCLVRDPQERPLAADLLRHPFFEGCTEETAVKNVKLAVEHMTRLINSDTKKADELRRTQEDVVKEVNTKLEMLGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8J3</accession>
    <name>F9W8J3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1736</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001171">
        <property type="protein sequence ID" value="CCD13525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42710"/>
    <dbReference type="OMA" id="ALWHAFC"/>
    <dbReference type="OrthoDB" id="1137224at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="457" mass="50555" checksum="DB15D1FF3C58F643" modified="2011-10-19" version="1">MPFTTITVAFDLRYTDWDLFESSREVFVATVGNLFTIALASAMHKQHQQRVQLLAVGDSKIHSIYNFVNGRGCGNTFEAVQRLIGLAPVRCPPRDSDRYVVNSLRQQQQEHYSSNEVRHHAMIFFTTFTTISDFSLLVCSTGPTALPFMNDVWTSIHLDDTAFTTTSLALTPTVCSIRCPIAPPCAQTALQQALSSSFTQLLPSTHVSLRYGRITVPCVAHRSYFALPTRCCAAEDLNSVQGTEEHTTLVLSGGHVCTAGCERERRATREVVLVAKGIIQPEAIDDDVLYGDVWLLRGRAPLGGYDRSPGEWLSHLATELRGDVLLLRTEQPLLDPPHTLALPLSFFVGFFTRSGEMCLRAVIPQELRVVRVESVVSNPSREGAGGRLDPALVAELQATTGTLRDCDAKVELRQSFGVCKMLSQLRPNPLFALRLERCQEGTAVKRTAAQLLHTRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8K9</accession>
    <name>F9W8K9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_42850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001178">
        <property type="protein sequence ID" value="CCD13543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42850"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394611" evidence="5">
        <location>
            <begin position="23"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="353" mass="37633" checksum="B71C1A1E51DACBBB" modified="2011-10-19" version="1">MEWDMSGRVLLFLFLLGMGTRAEGNNEDVFGKLCHIAGNVSVLMNSEGGDTDLLRKALYGADGRDPFGTGGTFTGGSECGLGYEMRSQYCSHLQGGSRGLGGSRGLGCFADSLFGTFMCLCVPGNGKERNLCGLEDVTGGAGWTGGITSDGHEKSLLQNVWYKIKQNCMERNTGVDTGKLEDAVNGIKTEPQKKKVKNGNKDYVTLGGGSTTSGACGGTSANETCVTYPSQDGKGEEPEILWANKISSAIKKLNETQRQASTQNSATPSGTSHSTDDDLSGQDEVDDEEVEEESVEESVTTSTHKDPSKPSRPRKNRSSPKPNEQPAEPLRALLHDGGSSLHQPFWILSAVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8W2</accession>
    <name>F9W8W2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001229">
        <property type="protein sequence ID" value="CCD13648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43860"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="25700" checksum="ED91CAFAC7FBAC09" modified="2011-10-19" version="1">MDGQVDSARFDYILSLFEQAVADTTYHEKNAQPPEDAKKLKRNGIITPIRHEELKGFAWPFCLEVLKKAGWRCQIILWPEEGDITSRMIFGYRPSLNIYNCKKYLSFVWLTGPALRVDLKASSYQMPLALEASRRLCFWAGGANSRWYIFRRLPVGHTLSPEIMQIAMSTLMGDERFKVKPLNLHPYIADTWIDDARILATKHGDITIAHHDIMKRVAECGAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9H8</accession>
    <name>F9W9H8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001312">
        <property type="protein sequence ID" value="CCD13878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="106" mass="12360" checksum="853F75A619BF7F05" modified="2011-10-19" version="1">MERKANAPRRGGAIPQTHHRNMMCSAPLIWRIDTPQRSYNRHARFFGRREKGKGRKTPTNTAIRPTIPCVGFKWRRARGATKGDWRHEKEGRGATPHAWVDTLQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M2</accession>
    <name>F9W9M2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001324">
        <property type="protein sequence ID" value="CCD13924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46100"/>
    <dbReference type="OrthoDB" id="1726455at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15683" checksum="FFB580434F217B7F" modified="2011-10-19" version="1">MIYFSFYSNQSGKFKPFQYKTEPLMVSALFPFIAPAAICWCAFTLGCTFRHNVVGSFFPLTSNVLTGACFIHTASPSKQTDKYPSGSNKCRPYGSHISVPFTRAHPFRYAPHSQLPVKLLLPMDGSAMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA38</accession>
    <name>F9WA38_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1927</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_47610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001383">
        <property type="protein sequence ID" value="CCD14094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47610"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="307" mass="33597" checksum="D03B5FA5C35C8BA2" modified="2011-10-19" version="1" fragment="single">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGKAPKTVDWRKKGAVTPVKDQGKCDSSWAFAAIGNIEGQWKIAGHELTSLSEQMLVSCDTNDLGCRAGFLDTAFKWIVSSNNGNVFTEQSYPYASGGGNVPTCNKSGKVVGANIDDHVHILDNENAIAEWLAKKGPVAIAVDATSFQSYTGGVLTSCISKEVNSAALLVGYDDTSKPPYWIIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA90</accession>
    <name>F9WA90_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48060"/>
    <dbReference type="OrthoDB" id="1698312at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22233" checksum="1DB968B6D5FAFE42" modified="2011-10-19" version="1">MRNLTKRLCIYLSVAAPACFIPQTFKPQTFKPEKKGGVAREVHLWWVGPFLASVLLLSHQLSEFTETKMPIRKALSCHTVIWCRALVGPPGLSTDPLHPTAPSPVGLWHLSGSCGLRSHPPHTHWRLTTAGQTMARVAGNLHSPGGLLVTSLFSTAVLLSEDSLVGQEESQTYSLKLWSTPSFTIATSFTTSQLGSSLYKPCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAB5</accession>
    <name>F9WAB5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001410">
        <property type="protein sequence ID" value="CCD14176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05190"/>
    <dbReference type="OMA" id="WATESIN"/>
    <dbReference type="OrthoDB" id="1668677at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390055" evidence="5">
        <location>
            <begin position="23"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="81"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="46312" checksum="9C03AEBD7AC2B8F4" modified="2011-10-19" version="1">MLWRGVTLLLFLFFWVRMPAFQEKYKQNAGEAELFCRIRLLAENDPEKLVFENEEREKQIMRQIEKVGPEIRTLVGKADQRDASLITQFNNLVKEAKTIMENMRDLRRKAAEKRVSAKRHLRQVIFGEYGGEGKGELDEKTETIKKIFSGDKFEESCGGSGNKMAGRSLINDFICLCAYNTGFDAHFNSHEDRSICMYGVTTTVEANFKNWTTVWHWNKHRICINTAPPIPTPQNINYLVAHFTRFLERVQENFQVKNVFGFLNATLNTNRVCDASKVGFTCVNYSHALQNGGIAWVNHLNNASQDLKDMARYAEESESSLPQLELLEYNALLLFEEAKYSTHLPQAVPSNETETNSSNESYPGDPTNSSDTSEEEKLEEEEDADSTWKGGTSWWGIIIFVFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAP7</accession>
    <name>F9WAP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001466">
        <property type="protein sequence ID" value="CCD14318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="16446" checksum="29CCDF7308953164" modified="2011-10-19" version="1">MHKLVPTQGNDNTNGYRLGESGSDSYPCGRNGEVCVMYHNNFDPKPWWSDLTKAIIKEEKNKSNRNRKLKLRNKKRQKSTKMRQNKKTRNPARAPCQNLKNRNTGLPRDQENKENISTPLAVVQHTSSTPIMQPLWFLSAALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT0</accession>
    <name>F9WAT0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001479">
        <property type="protein sequence ID" value="CCD14351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49810"/>
    <dbReference type="OrthoDB" id="1664434at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394643" evidence="5">
        <location>
            <begin position="24"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="95"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="427" mass="46948" checksum="BC4044D7A2AB52E0" modified="2011-10-19" version="1">MALFVNVLLASVVTCSLWVDVAAQGAEVKSVDNAEQFALLCRIYNVAKNPPINHVDLQDPNRIVDEIDAINASFSEKKQFNETEQVGNSSDAQVKRTTSREETVSQALLSRIKKKAHTILKEIRKLNETRNIEKVKSEFAEVIYGEEMNESDLCNGALKGVGDRGAACGRPGEMMKGTHSGKNMVVDFFCLCAMRTEAGGKDKEGVQDICGVYLGSKNGNHGWNTKCPETSSTMWASVKKGCGSLTHQSAKPRAEGHEVIEDFLKHLKSGGLYRWADVKSRGNNVVGSGRKEGMMGTGAGTEGGKEDILCNGSRGYGRSINPPGGVCVYYGPESEWDNIDWLKKFRTALSSTHTLNNQTSTIQRDIEKLQTLLHRAEEIYETAKVITEVQHPVVPTNLQTAAKRLTAYNAAWIHPTNTHFILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU3</accession>
    <name>F9WAU3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_49840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001481">
        <property type="protein sequence ID" value="CCD14365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1666285at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390070" evidence="6">
        <location>
            <begin position="22"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="18"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="82"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="47497" checksum="4420DAC0E24C88B8" modified="2011-10-19" version="1">MARFVKGIAVVIFSLLGVASGQVEVARDDNIEPFSLLCRIYNVAKNPPINYVDLQEADKIVEEIDELNRSLLEEKRHDEEEDVGNNSETQVKTTVTREAALAQLTLNQITQKAHKILDDIKKMNVTKEIGKAKAEFDKVIFGDGGNESELCQDTVNGMDNRSEVCGKLVMGQKEMVLERTLLWISFCLCAQRTVNSEGINQVCGFYVGRIDNYYGWSEQGPWGSSTMWASIKGGCGKYMQQHPKSTGEARHILDQFLKHLETGGVYRWGDSGDKVDGSERKAGMLGTGAGKKDGSGSGNSLVCNGKKGGKLPSSPGGICVYYGPESDHWNNNIPWVKQFQTALTTLNLANNQTATIQRSFKKLQMLQHRAEQIYETAKVMLKVQNPVGLPAAFQNASGNLTAFNTTRTRSYTCRTHTYFTILWVLFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC75</accession>
    <name>F9WC75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2193</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001678">
        <property type="protein sequence ID" value="CCD14867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54410"/>
    <dbReference type="OrthoDB" id="1735453at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394866" evidence="1">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17901" checksum="363C5BA9A36CFBBD" modified="2011-10-19" version="1">MACFVHGIYIIILSFLGVMSGQLEVAKDDNIEPFSLLFRIYNVAKNPPINYVDLQEPAQIVVVIGALDRSLLEEERLNENEDTGNNAGAQVKQTLTREAALTKLSLNQITQRVHKILEDIRKINVTKEIEKVKAEFAKVIFGVYGNKSDLCQEKVKDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCC7</accession>
    <name>F9WCC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54890"/>
    <dbReference type="OrthoDB" id="1709204at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="22147" checksum="7323E5FCBC29D1A6" modified="2011-10-19" version="1">MPKRGIRENIYLFCVLLVVTLVLFCYICFTSSYHKLIFFLLFDNSKLAAFSSSCRADTIEHTRCIRTVERQSDNFTLLPLNQHLTPSGLRYVSVKERKVISLHMHARKWGKGAVLRNFFSHGGEKKKNNKKNPHVVVAGGKRVVTSGLARLLMCVQHGDGRCKHIRGRSHIPRWWCSSLACVYRVAVDLLYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG1</accession>
    <name>F9WCG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001718">
        <property type="protein sequence ID" value="CCD14954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14455" checksum="B10840BA11EA2BFC" modified="2011-10-19" version="1">MVRGESCVGGRRSIKVATPSIYFPFKVTCRAPIPDCYTYLPVTESNNKLLNTVSTLPTVGGCVGATPSLSLLTTSALTGTIFCYRGSLACIKIHLARGTILLRILPSIARKYIVKIKLQGITIRCLHVVRIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ7</accession>
    <name>F9WCJ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 2240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_55580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001731">
        <property type="protein sequence ID" value="CCD14991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55580"/>
    <dbReference type="OMA" id="NGNWSEY"/>
    <dbReference type="OrthoDB" id="429638at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="PTHR23323:SF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="6">
        <location>
            <begin position="505"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="977"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1101" mass="122557" checksum="9F77D88ADD3D0FBE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCM3</accession>
    <name>F9WCM3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_55830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001738">
        <property type="protein sequence ID" value="CCD15017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55830"/>
    <dbReference type="OMA" id="CDINGEN"/>
    <dbReference type="OrthoDB" id="1265661at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="58"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="293" mass="32085" checksum="5890F2E826C2D8C3" modified="2011-10-19" version="1">MERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGRPPMTVDWRKKGAVTPVKDEGKCDSFWAFSAIGNIEGQWKIAGHELTSLSGQMLVSCDKKNYGCEGGLMDRAFQWIVSSNKGNVFTEQSYPYDSSWGDVPACNMSGKVVGAKISSYVDLPQDENAIAEWLAKNGPVAIAVDATSFRSYTGGVLTSCISRRLDHGVLLVGYDDTSKPPYWIIKNSWGKGWGEWGYIRIEKGTNQCLVQEYASSAVVSGPPPPPPTPTFTQELCEGAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP3</accession>
    <name>F9WCP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001748">
        <property type="protein sequence ID" value="CCD15038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56040"/>
    <dbReference type="OrthoDB" id="1732243at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="18408" checksum="8C94D785986DDF38" modified="2011-10-19" version="1">MSTIDMHNPTCTTLLYVELYAAEQATRRKIHRETFSFFFFFFKNKNTMTVLRTLTRQRLMTEILVLIQMRNEYTCTVTVHNTLTPQMYIYIYILLTALRTSVFLPFLSDLVQFFFFLEDPLESACHLKDSNMCEKENEGKREHYPFFSLFFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS1</accession>
    <name>F9WCS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2260</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_56330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001753">
        <property type="protein sequence ID" value="CCD15069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56330"/>
    <dbReference type="OrthoDB" id="1659393at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="564" mass="63381" checksum="C15C864D63DB1E59" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCV0</accession>
    <name>F9WCV0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2275</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001770">
        <property type="protein sequence ID" value="CCD15098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56600"/>
    <dbReference type="OMA" id="PLDITYM"/>
    <dbReference type="OrthoDB" id="688282at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="258" mass="28742" checksum="3215EE429964ACCB" modified="2011-10-19" version="1" fragment="single">MPSKRPNLQGLSLEPPEKAVSITDTLTLVVKGDGGAEVRVKASGITSASPVTAEATQLGDTSALQDKIVFEDLQVRHVLGKGSQGNVKLVRHRLTNHTYALKYILLDRGAEDVREALESELRQVRAVRHKNIVTSYEAYFREGRLYIVLEYMDAGSMMDVLKRRSNHFTEEMLAYVARELLYGVEHLHSLKMIHRDIKPVNVLANSRGEVKIADFGVAKKLSEGGEWTMSSQGSLIYMSPERVKGELYSMSSTYECGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD09</accession>
    <name>F9WD09_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001799">
        <property type="protein sequence ID" value="CCD15157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05820"/>
    <dbReference type="OrthoDB" id="1671413at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388997" evidence="5">
        <location>
            <begin position="18"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="38506" checksum="85DA4717AA464D45" modified="2011-10-19" version="1">MKLKCLILVVMCLVVRAEESGKKDHNGDAHNALCALLKAAVTKWGNGGQDLSEPLKKALGRTLFGNERGGDVTSLKGDLPEDYKNEEGKLPLRFTWCGRPLEGATEKKNAWWPGHSAPHDLVCLCTTGKTGYPFNDVGSGSGTDTKLCGQPKEALGGGSDGWASSGGTIQQINATWVNITQKCLEAAKNGKNLKDALGDFLKKLKKAPREKYPERYQLGEGTSDEYACGGGGTICVMYYNDTTVTQQQHAIPWWTELEEAINNQAYTEQEQKKSEEKPKKEGQNQHHTQKHENTQPQQAPRTAALKQATPDKQGAEQENPENISNPIATLEDTSGTVIIPPCIWFLNALLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD40</accession>
    <name>F9WD40_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00700</name>
        <name evidence="2" type="ORF">TCIL3000_0_09040</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001818">
        <property type="protein sequence ID" value="CCD15191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002103">
        <property type="protein sequence ID" value="CCD15912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="15766" checksum="D3BF459D0E215587" modified="2011-10-19" version="1">MLEIMKLTSNAYLNIPTRLPHVPCRGQKPQCGQQLLHTFGLHHVPRVLGCAWCRAVVVTPACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAHRNGERCGTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA1</accession>
    <name>F9WDA1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_05940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001844">
        <property type="protein sequence ID" value="CCD15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05940"/>
    <dbReference type="OrthoDB" id="1741067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23311" checksum="3BC36DD93E4F0E0C" modified="2011-10-19" version="1">MWGEHRSGWVIDNCIEEDQEQKVEVAMEKLNNNLTTLEILLENKNINLIQSEKGNVKDEEVCAKVARKPEWLKTLKKFVEIVSKTLKEAQRQESIRRKRETENGVPTGTLTQSPAAEPGPEPTPQPAASPAPQAEPGGLQTAEATTKQELPRATEKKPKEEPKTEPQGKPEEMPPKPAEDPIPTSETDETNSSFLNNQKWLFWAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDD7</accession>
    <name>F9WDD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001861">
        <property type="protein sequence ID" value="CCD15290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58210"/>
    <dbReference type="OrthoDB" id="833306at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="266" mass="29314" checksum="97813B56329B606E" modified="2011-10-19" version="1" fragment="single">MVEPQSLKNGSSQPSLRENRNRSTEPTHNEKDRPAPPPSMTNKGVGLSKPGSVSTAPVARGATSDEASGVAAGKHREPRGAQEPFGACPAEEEDQVEETKDVSVVINQVQTMLSDEGCREVAYLLFDEQFKKLERKPSFTADTWDDIKYLGKSEKCCGFEYDWERNALHIIFMGCKYRFFALSFVLRLLCIIFFWVILLAIGPKEKFLPGGPYFDTGATILFSGIFGSILSKVTRIPSVACMVIAGAIYNNIPPTGATTRGIEPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL8</accession>
    <name>F9WDL8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_58990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001885">
        <property type="protein sequence ID" value="CCD15372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58990"/>
    <dbReference type="OMA" id="WADEITA"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="884"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1225" mass="135041" checksum="623AEAA66698ED3B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDT8</accession>
    <name>F9WDT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_59620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001913">
        <property type="protein sequence ID" value="CCD15442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59620"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="204"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="118"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="235" mass="27058" checksum="7C71069D9A65B3BE" modified="2011-10-19" version="1">MSWKEISGGTKKMSNTKNELAPPGEEAAEWRKLAHGWEAQARRLARLKCHHEDQAVDLGLVMESCAEFLELVTEVIKKACDLKGKDGKKNVEKLERALKKWPEYLETKTNYWEKRLRVQKGGTEADAMKEELKEQEKQADELEEELETIEKNLKKNIVPRRGDDPRLGVCPYCDSEYKSIGWLKRHVRDDHPGQPVPDIMERGLKCPHACGKTYKTQGWLMRHLQDKHGEKATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE24</accession>
    <name>F9WE24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16204" checksum="CB7EF995CA6433C2" modified="2011-10-19" version="1">MKNEKNKHHHKNSFCNNYFMFFRVIFSFPSPGALQNCFCNNYFVFFRVIFSFPSPGACKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFHHPARCKNVFATIISCVSESSVVLRHATRCYTELSTVISSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE57</accession>
    <name>F9WE57_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001955">
        <property type="protein sequence ID" value="CCD15563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06440"/>
    <dbReference type="OrthoDB" id="1179262at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="2">
        <location>
            <begin position="359"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="506" mass="54502" checksum="EA24E527ACE848DA" modified="2011-10-19" version="1">MRPGPGCWGEISRNENVQCTVVEQSLLTLRTYSLYCEAANQGPGLSGVPLQQSPNAIAASVLVHSYRVDEQGQRLVSASSSTAPQRYPAQSPQQGGGRKQRQADEKRRMVGPVGTEAGGRGGLSTVAGRKRSADGLMMQAQGKKQRAAWGDTDPADRGGGFGTSASVGCITSNINPPPSIPPAAVSRPGGSRARAQRTAFSPPAATAVRKSRKTTPGGKSAAAASVDVHENASKSEELWQHLERYCADGHQQAAKPPKLFREGGASTLISNRIPSRENIRCTVNLFGENERCRGTQGQDMPPAENTALQGTPAPFSIPSDVTSYNSRMNPPASSGVNMLPTMPLISPTQYAVRDPPVHVVLDTCSLLKADSDIMDRIAAHGVVCVPCGVIAELDRWNHVKGRRKNNKYSSNGISGVTARHIRDWITQAVKTHKAARIQRNCEVHDAYDRKVTTADDAILGFAVYLLKEEKLPVTFVTEDKFLQLKAVFELNGNSHTLKDLLEQRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE75</accession>
    <name>F9WE75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60670"/>
    <dbReference type="OrthoDB" id="1670168at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40854" checksum="BE613719E8454F33" modified="2011-10-19" version="1">MNKPHGYHRPTGWWDDEFVPNHQDVWYYRATTLCPPRPCTMRTSVLDVLADSVNDPDNLNLLHFLERWYTDLPLHLLRFTVGDFIRDPERCLLEDRLSQEIWDNLARRRTHLYGEMLDQYFALSGAQILTLEDWAQRGSSLTVHPLARGFLEEAVKQAKEPVEQQKPVYLPSPSSQPMSPRPESSPVQEVQEISVVPPIPKPQEVPLSHGSPPTRQKRQPSPPMESMDVTPIPKPQEVPPSHGSPPTRRKRQPSPPMESMDVTLIPKPQEAPPSHGSPPTRRKRQPSPPMESMDVTLIPNQQEVPLSHGSPPTRRKRQPSHSDVKFLTVKSATPPDVLTRPESPQEVNVLSGDTAPPPINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK5</accession>
    <name>F9WEK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_00790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002028">
        <property type="protein sequence ID" value="CCD15716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00790"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394947" evidence="4">
        <location>
            <begin position="27"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="77"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="423" mass="47853" checksum="C0C64001B5EFA427" modified="2011-10-19" version="1">MKEGDTMNIIKVSFVGLLLCLGSGRGQPSKEEFNLFCRILVEANDMILEQDYAYDERKEREALKEMEVLYNATTDSMNEFGKMLWKMRNFFEEHPPPMQLKTRQEAHKEIGLLIADGERKIQENRHISVVINKKMEEAKLSVLQGMYGQNVKGVPKDDGEFITILRDKGSIFVDNTTVGNSCGKHNASGKTLINDIFCVCVGEGNTDGKSAGPCHTDILPPKKNNNDGRWTQVKYEKGDNNPIPLTESIEKIEYVCHELLGGSNKKGNMPALLQEFVGMIGKGEAKPSKNKIFGQSGRIKGNGNNSVTECTGAGETGYSGKSDYHNENICVDYTHNYKNNKYEIIWHNKFKHSLHIMKEAKEIEGKILQNRVEILMMKTKAWYAYGREKEDQTANLDDISVTVEHGNQNHFSLLFVICFFLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEP1</accession>
    <name>F9WEP1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 296</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002044">
        <property type="protein sequence ID" value="CCD15752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07630"/>
    <dbReference type="OrthoDB" id="1725167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17532" checksum="23CEDE4534715024" modified="2011-10-19" version="1">MLYLDEGGWAEKRRGRLFFVKNPSGDREDVLQGVMLSGEMLVVAEPSLVEDRLRRFWVLPRCSVDSSVRCESLALSHSVVLDREPMVRLRRRVLVLIEFLPCLWWVGRVLPLFWYPGYLPPPVRNVWTLGIPVPMGTSVVDHIGDDAPAFWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEU8</accession>
    <name>F9WEU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 316</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002066">
        <property type="protein sequence ID" value="CCD15814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08150"/>
    <dbReference type="OrthoDB" id="1153955at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000079">
        <property type="term" value="P:regulation of cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="entry name" value="PTHR15615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="690" mass="75064" checksum="5B65D1C2D54520B4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEW4</accession>
    <name>F9WEW4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_08310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002070">
        <property type="protein sequence ID" value="CCD15830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08310"/>
    <dbReference type="OMA" id="YVRWAVR"/>
    <dbReference type="OrthoDB" id="1314061at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="40969" checksum="BDE8623C1C8EC269" modified="2011-10-19" version="1" fragment="single">MLIHCFAAPGVLIRRTVRVGALGTRLTGYSAAHTSLSAVAVATRCFSWNPASWVSSEVVGRSSHQNIEEELPEVFAQQPMEVDDFIRPEKSVFERLEDFWDWIVGFFQPIEKQLEFMRHLRNNGFFGFDLGGWGNIFFFYGVCMRLFTLVPSLLSHRNALRLSHINPQISEITTCQNRAKSDRSLSTAERRVIKEGYNRMKLALMKKHRCAQWKNFLTMITAPITLSAFFSVRHLAVYETDLEKAPFLWVSDLTMPDPTYALPAICAGMFLMNFELNQMMQRGGRSSTGLYVRWGMRVGSFVGVYFFASQPAAIFSYWIGLSTAGILQPLLLRWQPFRNFFQLPDPPAVAKSHIIADVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEY9</accession>
    <name>F9WEY9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 327</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002078">
        <property type="protein sequence ID" value="CCD15855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08520"/>
    <dbReference type="OrthoDB" id="526233at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="267" mass="30745" checksum="6948C4A59DC809DD" modified="2011-10-19" version="1" fragment="single">MWRLSCRCCSRLTLDQSLVSLPRDVRRVVVYRNAASVDFEQRICAELEVVLQRDGYSAFAETSTPQQKIVKHTYLEMHGEHRGFTEVKSTQRKEARRLPGLLWSPTMVAWMKEVAPQLSLFPPGVIPDTARVVEHNMAGYEMHTEHPTVGSCFLYLSLLSDTVLNFDDEATGRRGEVFLPQRSLMCCSGEARWGWRFGEQSRDEHTFVNVTGVRRTVPTDLRLSIQLWRFTPGLLDARLLQDRVEESIQQLDKVKEVSVLMSFRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF67</accession>
    <name>F9WF67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14963" checksum="2528D523BC3829E3" modified="2011-10-19" version="1">MPWKPSWPPSQINQSFRACLLKSTRCERSPFDACYEHFPADFFPHMCRCDLVPAHQPTVHFAIHQLHQFMHGAVLMPFMWIVQHPHAIFEAIGNQFQCTFHFLHTLLKGCLISHGAVQHRTHYGNKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>F9WF78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 359</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002114">
        <property type="protein sequence ID" value="CCD15946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09320"/>
    <dbReference type="OrthoDB" id="1739832at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="20324" checksum="4A3458BFDFD59B07" modified="2011-10-19" version="1">MFFFIISSSQPCFRIPLAVDLLTFFITFRLCAFLWFLLSRFSFLFFSFSISLNSALPPYFDHFVPPYSSPYQAHNSWKRKTKELTHPLPSLPFLSPSHVPLSMQVPRLLVASRGTSRSCVFDEGLSGNRLLVRYAYKQLKRVERGKPPLFSFVSISYESLQEGPHRSKGQIRKSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC3</accession>
    <name>F9WFC3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002125">
        <property type="protein sequence ID" value="CCD15991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15024" checksum="6AEC2EA15FD2B318" modified="2011-10-19" version="1">MVYQGRGRFKLIPAAGTGSMAGARTDCGTGRKWAKKIVGRIMGWWQACFPQRVVPNIQTLAIESPEKIPQMDTRKSMGVRVGEAEREAKETSQSLPAKSHHYVSTHVKSAGIVDSRDGGRSGGSASPYELRSSGSVFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK8</accession>
    <name>F9WFK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10470"/>
    <dbReference type="OMA" id="GNDAVEW"/>
    <dbReference type="OrthoDB" id="1562360at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="47414" checksum="DD443F70CCCBB452" modified="2011-10-19" version="1">MIEEPELNSEQWRAIASVYHLYVTGTGGDSRESLAHQKDGNDAVEWVKGVLPSLKRAFPQKFLDRMRERWKAEARTSAKRNGANESRRKGETRSERASADRRRGELWRQELPHYIDSFLSDLFHQDTLISLTRREQVLLCLLNKEQQMLEKCSQRHKVLKEVVHHMGVKLINLAESEANGDAGSLPETRGSTSHEKELSDWDHDPCLDVMESDEFLTRRKVGTAVSKGGKARNIGAVPVEKGTAPVVVTDIRSSSSSSNADSADGTPCVRKPNHAQGIADPIEFICVECNEPGGDLFRCHHCHSLRHERCGGPRIGSEYCFCKKCYRHFGFNSSSTSLRSSTSTDERLQLNECDDDTSLSGFIVLTSDEDEENEDKRNSPKRKRLDRSSSSSQEVQVVEFEEPPSRKGRQGQRKRMRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM1</accession>
    <name>F9WFM1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_01270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002163">
        <property type="protein sequence ID" value="CCD16097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01270"/>
    <dbReference type="OrthoDB" id="1185596at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="PTHR10676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MT" evidence="4">
        <location>
            <begin position="191"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="754"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="542"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="907" mass="99603" checksum="EE4FEA6E55445099" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP2</accession>
    <name>F9WFP2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_01330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002174">
        <property type="protein sequence ID" value="CCD16119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01330"/>
    <dbReference type="OrthoDB" id="1667605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389079" evidence="10">
        <location>
            <begin position="25"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD16119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="42615" checksum="714C79C6118902DD" modified="2011-10-19" version="1">MVMELRSKWWWLVGVFMSWSTVLGTGDTPTKAIPTKAGAAICTLSKTLKDITPWATQQVEEGSAKVTHLEMKLLDWQSKFIQSKSKGIGAEACKVTGLLFRQVRKEIDKARKEVEKLEREASKAAAFAANSAGRLDEFITVFANAKGGDHNYCLGRDKAATAGELKDCFSKTDFSEESLVDIGERVSVQEPNLFPKIEGIKYSELSSHFTAGSGGGCNLIKGAKEGILKSTNLENSLWWGGGILSIGATYGGTRSFDPGEIPDATNNKEKAFWTENPATQIVHLKNASDAFKAFKAVHETIQAKIEDIEQKIQSCMGGEEPGVNTTEQNTTEPDIPPPTSPTCFDNVAKIAADLREKRALLARYQKVKGWIPPSSASHPTTQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ4</accession>
    <name>F9WFQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002177">
        <property type="protein sequence ID" value="CCD16131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10820"/>
    <dbReference type="OrthoDB" id="1693627at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="26441" checksum="47B33BDF6568FC15" modified="2011-10-19" version="1">MMLSPHISLVGPKLTHIVGNSACLSKAFPFTTSGTFSGSCTHTHTAIRMLHAHQWMRPQGLTHLPLGRTIGSQHNTYHSHLRDLSGHIKHMSDTMWSRTHSPVPHSSLVTERPGLNISFPLPSARQGKFTAYQHSTARPRGKAMESALSKPFLAVARQATAKGAAQRGLILLRVLCSQSSQLIMPSTDFSHKMRSSGLPPQRHNHRVADMLPWRDIPPVAHGPPTKQPEGTWPLSSRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ5</accession>
    <name>F9WFQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002177">
        <property type="protein sequence ID" value="CCD16132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10830"/>
    <dbReference type="OrthoDB" id="1715557at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18265" checksum="85ED478E13EF3308" modified="2011-10-19" version="1">MEPHLILPEASLIQSRLPATRQRFGIMSARHDFVLLYSNQSERFKPFQYKTEPLMVSALFPFIAPAAICWRAFTLSCTFRHNIVGSFFALTSNILPGACFIHTDGPSKQTDKYPSSSNKCRPYGSHISIPFTRAHQFRYAPQTQLPVKLLLPTEGSAMCLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFR8</accession>
    <name>F9WFR8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002182">
        <property type="protein sequence ID" value="CCD16146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10970"/>
    <dbReference type="OMA" id="VACANTR"/>
    <dbReference type="OrthoDB" id="626048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="42471" checksum="BE5D8A2270CE078A" modified="2011-10-19" version="1" fragment="single">MINELCHPSIRTPSKCIVVACANTRYHVVRTAAVQLGWHVEDGDREDVPPSFHGISLGEQPNSLSCAVASRGIKYDAAVSPQILWLDKSVVGSRVAALSCFHRINHFAGMHVIARKAVLFRRLMRIRRQPDLAAPLSHALASFPWSFTPSTELLLLERFISDCDGGDIFILKPNKGCQGKGIVVTPEPLRVLSRMTPDEMNDCLVQQYVTRPLCIDRKKFDLRIYVLITSVVEGKPPRRGLHCTSATANKCDKKTTTPLDGLKLFVHYDGLVRICTEDYAYPSEANCRHENMHLTNYAVNKTAGNFAIEEVDADCGGGGVTREGNKRDFKFLEEYINALPSDSYTETEGVCSTADGSVGSRWSTLLRRTDRCISLRRSPGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGC0</accession>
    <name>F9WGC0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 488</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002257">
        <property type="protein sequence ID" value="CCD16354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12920"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="33892" checksum="C534E8BD455AB890" modified="2011-10-19" version="1">MHHHSVCQCGKLLPHTRARTCLSSCNCLIPLILPHAVAENTTQETMRFFSGAALSFFVLMLHAADVGNAFPAWGRSPICIEGLKLLKGVEDRFSEKLKTYALAINSTESLRAHCERLMEVVGSTADANDVRSRVKALKRFYVEFVKDQSVAAELREEVKRLVQDIKRECGSWIRFILGSWGIKNDVRQKLADGDRMKKELEKHVSKINNMWAAVNSTGCSVEYYDRLLEQYKRKHGPSNGTGGQPAVQEPANANVSSESTESAGSGGSTTGGSNGTAGVDDVTGEGSGVPSGGESDGESNSDINSDSDSDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH8</accession>
    <name>F9WGH8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 503</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_13380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002273">
        <property type="protein sequence ID" value="CCD16414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13380"/>
    <dbReference type="OrthoDB" id="1722147at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20715" checksum="28177FE11458274F" modified="2011-10-19" version="1">MSRSRLSHYGTGATHSRGTKCWPPTQGTQRCWHNCSIILERGCSHAPTSMERRVSMRAVYWLLECKPTKPQGYPLVRRMLTDNEDNTPRSGTSSDLLSLICRTIRAITEAPRPSRTSIAFPSAHDPQSLFLSFCVVGGVFRWDFFPLCLVLLHTVCCLSFFIIFSFLCLCTYLLFFFLCGVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN7</accession>
    <name>F9WGN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 524</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13930"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="66"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="49697" checksum="5A5F1B9D2DAF1DDC" modified="2011-10-19" version="1">MSSAAPNPVPAGTEPVELTAVGCKGNDEQRHDTNPTPKPEDSKENVGCFAKVAAFVAATIPPGGIAASAFNIGSTTVGAGIFGLPAASQGSGLVMPMFYLLVIPGMAVFSTYALGVAADRSKVNTYEGVARVLLGKWGAYITALIRVLTSLSGCVAYVISTGDILHATLKSSSASDFLKTTAGNRLLTFIMWLCCMLPLVIPRHIDSLRHASTVAFVLMIYMVAVVVVHSCMNGLPENIKSVSVGRNESAEVVLFNSGNTAIEGLGVFIFAYVFQVTAYEVYMDMKDRSVRKLVIATIIAMTMCFTLYALTALFGYLDFGSKATSSILLMYDPLNEPEVMVGYVGVLVMLFVSYALLGMSCRNALYSLIGWDANTVAFWKHCIAVVSLSVVMLVCGLFIPKINTVLGFAGSISGGILGFIFPALFLMYSGGFTLQKVGPLCYIATYVLLLSGVIAAVFGTGATIYGVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGU8</accession>
    <name>F9WGU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002330">
        <property type="protein sequence ID" value="CCD16536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01670"/>
    <dbReference type="OMA" id="ILYRAVA"/>
    <dbReference type="OrthoDB" id="225653at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="PTHR23082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="747"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1170" mass="129753" checksum="7EDB011C14976773" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH01</accession>
    <name>F9WH01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_15000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002357">
        <property type="protein sequence ID" value="CCD16590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15000"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389130" evidence="5">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="89"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="46665" checksum="6BFEC4226675049A" modified="2011-10-19" version="1">MSFFKNVVAFLVMAVGSFVSGQVEVAKDDNIEPFALLCRIYNVAKNPPINYVDLEEPFEIVREIDALNRSLLEEGRLTEEEDAGNHSEAQVKPTVTREAAVAQISLNQITQRAHKILEEIKKVNVTEEVGKVKAEFNKVIFGDGGNEDNLCQATVNDMDNRSKACGPPGLTSNGESAGKNLVVDFFCLCAQRTDEEGANQVCGFYVGRISHYYGWDDKNGPWGSSTMWASVKGGCGKHMHQHPKSTSEVRHILDQFLKHLKTGGVYRWGNGKVEGSNRKEGMLGTGVGKNENDSNGPTCNGKKGKNGQTPGGICVYYGPSDWDSNIHWLKKFRTALNRVENINNQTATIQRSIEKLNMLLHRSEEIYETGKVMLEIQNPVGLTAALQNSSGNLTAFNSTRFRSYGYRPHTYFIALLVLHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH03</accession>
    <name>F9WH03_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_15020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002357">
        <property type="protein sequence ID" value="CCD16592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15020"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394772" evidence="5">
        <location>
            <begin position="17"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="78"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="43293" checksum="48997F5780CF5034" modified="2011-10-19" version="1">MMKLFMVCLVVMGGWVREWRVKAEASQTVSEGDNRGPFELLCRIYNVAKNPPIKPVDTKEYQKMVDDINALSTAANGKERVNTQTEETKSAQTQLTGVTHEAHKLLNEIKKVNPEGEAERAKNTFNQVIFGENAKEDLSQGALEVEQKRMTACKNGEKQGTSAGKNLVVDFFCLCAQNTVDADGVDKVCGVSVGSGDGTGWGTNLVSSDTMWKEVKNECEKSAKQSATSTDAGHSLLRDFQDKLTAGGQVKVKDKDTLRTPGMLGTAVSAKGNTDFNCNGKSSTYRDTGAGICVFYGNHHQEENIAWLKKFKEGLQLIDKLNTETASWKSKLTTLLNQARELYEKVKADTQQEQVDMEEPIAAQHPNSDENENADSTTRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH31</accession>
    <name>F9WH31_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 586</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002366">
        <property type="protein sequence ID" value="CCD16620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15290"/>
    <dbReference type="OMA" id="CIARRNE"/>
    <dbReference type="OrthoDB" id="521694at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="262" mass="32066" checksum="09A235D1E9B17B1B" modified="2011-10-19" version="1">MIEFYDKRERELVREFNETVAKLQDIMYNAIKVHEEKLHECWKDMERAQQEKHEQIVKDLNLLREKEEKDYHARVTRIEQDNQRRYEQYRNEMTLLEQRQKEREEHLLVDISQRERELSEREQRLRVQRAQDEQDNKVALLARETELKAYYERLMDNMRTSFDKEREKMTKFFHDQLQEISQLHLDNERKLEATHRDKEREMAQRYRVAGYEADDRKGDAELRDVSMATQSALLSKFDIIEARQRERAEKARAAFQGKDGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHE8</accession>
    <name>F9WHE8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_16440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002421">
        <property type="protein sequence ID" value="CCD16741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16440"/>
    <dbReference type="OMA" id="ILNAMYS"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="854"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="899"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1247" mass="136990" checksum="9A894B595E279EAD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHG4</accession>
    <name>F9WHG4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002433">
        <property type="protein sequence ID" value="CCD16757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16580"/>
    <dbReference type="OrthoDB" id="1714275at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21138" checksum="BD8E24CAC607D996" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVDVLLDGVTSADRINLYWFLRPVLAALPVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTETWEKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPCQQVVVVEASPAFIQVPYSTVRYLVPMPVSPGSRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ0</accession>
    <name>F9WHJ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 655</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002443">
        <property type="protein sequence ID" value="CCD16783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16830"/>
    <dbReference type="OMA" id="CEEMNDA"/>
    <dbReference type="OrthoDB" id="800633at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="625" mass="69312" checksum="3F3F8EE12E2BFADC" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHT8</accession>
    <name>F9WHT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_17670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002485">
        <property type="protein sequence ID" value="CCD16883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17670"/>
    <dbReference type="OMA" id="WATEWPA"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390355" evidence="4">
        <location>
            <begin position="20"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48971" checksum="FD3A55F555D2A622" modified="2011-10-19" version="1">MNPVRLLLVAAICSSFACSAEPTSREGPNKKQFNILCRIYRAVSAAPTSVFDQEEVDRIRDDIDVINASFGEHRWFHGIAEVDPHAKPEEISNTQYEEAGDLWPRWKKAVEEVISGPTHVKKLPASSPVVRVARFKLIKIEDRVEEILRDIREKSESAGLGQLNKTLQEAIFGEGSEGKLLPYQYSNRADNCGKISTYRQGTNTAGGKSMAHDFICLCATNKGSVKKPSEGGDNCLGGVASTKEWEQGDRGTGNLETIWKSIKDECSQMVKRPSSSSNLEDALHSFLDEIADKRGIKAPVLYGVLGRLRPTSYRSGAACNGENGSQLLEGGGACVIYKVKNGPNQEPDIPWFDKLKEAIEQLERIKNTTDSIRHDITELKMLRSRAEEIYETAASTADVASLLHAHLTGNFSEMLGPSAPGWLQSLSAVGSPNQKSIFLAWFFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHX6</accession>
    <name>F9WHX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002495">
        <property type="protein sequence ID" value="CCD16921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18040"/>
    <dbReference type="OrthoDB" id="1708224at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21162" checksum="73ECEF893AFC6DCC" modified="2011-10-19" version="1">MSLYTITSPRTTPWSMEKDVVEVLLEGVASPDHVNLYWFLRPVLACLPVDLVCFTLRDFVRNPRHCIPESNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPPPYQPYQGVVLVGAAPAFIQVPYSTVGYLVHLPVTPRAWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI07</accession>
    <name>F9WI07_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 715</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002509">
        <property type="protein sequence ID" value="CCD16952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18320"/>
    <dbReference type="OMA" id="FEKDGPT"/>
    <dbReference type="OrthoDB" id="1400935at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="499" mass="55556" checksum="AB478D4D2700561C" modified="2011-10-19" version="1">MKNKTVVSASIKLCFCAEAKSYSVHFTFSFRLFSLFFVLLATNCQACRNSSASLHRSLTSLFVSSCQPPPTPHPRGTHIQRVGPNRIRRRTHAFAYTHDRVEQEKKERRENSSSAVVVTLLPMLRRTLWCLLEKEPQIVRRAIMAKARPHPGGMHGTNSGSSNRATDVMWRRNGVGTNALQRSVDSAASPSGSRAPTILLGPGSSQQQRQQHNAAATARDVDKASSTASDDAYKFLLHHIDSEIAALTRRVTTVGRQRESVKGNQSRRIRQLFECIERPWLLLESIPPPQLPNKPLDVFAKEMYVRQHGTSTSAWEEDALFLSNCRRNWRVLSVQQRKPYEIAARRNEQTRKELKKKINNGCTYFEKLCEQTKEWTAEMVRGELRRVASGKSHAAAPATSGRSTLEANKPTVKGAGRPRTAGKKPAVKSRAEKKDPEVEVLTFEPVVKKKPGAGKKIGRPAKAAAPKSRKAGGATALPKTAKKAPQRQGAKKKPKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI09</accession>
    <name>F9WI09_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002510">
        <property type="protein sequence ID" value="CCD16954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="117" mass="14278" checksum="6190AB2460A0C47E" modified="2011-10-19" version="1">MRKYKKITAYTNGTWSCYFNFMSRQSGSIVNELLNILTKRKSRKRLQHAPRPRRRGLDRMSSLKHRRFQTAVRGKEHVYIRKTAQVNTMKLQVRKHSCRRLSLFFYKKKTERERTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI61</accession>
    <name>F9WI61_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_02030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002531">
        <property type="protein sequence ID" value="CCD17006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02030"/>
    <dbReference type="OMA" id="VWETDYE"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="41575" checksum="9FD55F0744EC3570" modified="2011-10-19" version="1">MSLRWAMLLVSIASWYIAITLFLIGPSGVVTRAPPAELTRNYPGWMRQALAFTPAAAIRKWQHIDYLLVLGIPSVDMLERQRRRNLQRTTCWQYDGVARRANGFTGAMLPLYVLARHPSNGYAYTDAMRREVLKWSDMIALPMYEGKPSTNKKVGGGGKWGTEAEIGMSRKTFYWFDFALRMFPNASYFAKGDDDMFLRVPQYLADLRSLPRRGLYWGTMDRFTVDGYRFTYAFGALYTLGRDVAERFVSYLPLKSVIDLPYSEKEAHKFKALYLYAEDAMVGITLKRAGYSSKLFHVNEKKCSFHDIHAGALVGPLSPSSVMVHHVKEEDYGALMKRFNDGKVVAPRNLSSSEFSSRRMFMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI99</accession>
    <name>F9WI99_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002551">
        <property type="protein sequence ID" value="CCD17044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14514" checksum="FCA0B6889D5CE1F2" modified="2011-10-19" version="1">MSQMRGDYATTAPKLVGFIFVQREDARGLGSGGNVGNSGYDSTNPPKPSPARHPRAWSSDCVLVVLLVPTHTTETRRQFPECGGMEHGPTYERSVPLGCGVVGSGPPHTEKTRWSNTTREGKPRRKGVLRNLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE3</accession>
    <name>F9WIE3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 775</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002575">
        <property type="protein sequence ID" value="CCD17090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19430"/>
    <dbReference type="OrthoDB" id="1708569at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19422" checksum="DA74BE81B5DFD295" modified="2011-10-19" version="1">MISRGEWRDTCCNISHALNPSLGLGVPIPKLSSTLPTRLMRFLGKCETLCTPLNPPACCFGRPFRQSSGHKKKNDSGNFLRHNSMTSSLLEHCLRPRATAQIPKRHPNGGPRGACVAPWSKYRTSKQWPAGSSDGAYLSGCPKQAQPSTKQLCTVMLDRNTPKRAATISVDRLHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF5</accession>
    <name>F9WIF5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002584">
        <property type="protein sequence ID" value="CCD17102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="14875" checksum="40D34676EE5C6044" modified="2011-10-19" version="1">MTKNRSNSENNHQKPLFGQKTKKKKNFFLIFLRKICKKGVSPGKPKKVPTRITLQNPLSPKNKKRKKYFFCFFWENLEKKWYFTSVMQKNSSNSEITTKNTLFGPKNKKRKKFFFLHFFAKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIG8</accession>
    <name>F9WIG8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002587">
        <property type="protein sequence ID" value="CCD17115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02170"/>
    <dbReference type="OrthoDB" id="1668132at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="48496" checksum="3F56700A840EEA0C" modified="2011-10-19" version="1">MNMLEDKMTDNLAAEPEILQDGYNGAVPCDEPQLTPRPTTDDTREKSLSVLEQNDIPTDSPGKVLEDMQLADECNPAITTECEREDEPDNSLGVSDQLEEEEEEGSTVDDGDAVSDSAVNEDQPQARKVPVKPSQKDGVRRRHRRVREADYKAVTSSVINCAWGYTFSDTTGHVERSLLPPELLESREARRSHLNTPQALRLRVAQAARQYALAATGPESVEETSAAPRLTVSLLFQGPPPESGSSQASVKTHASPSCNRDRIPAEDEIRSDEENGEGSDRGVSMGDHGGHGTTLFHEPAADDDIKEGSVPHDDEPACMPSQGLPDGGEAVNDVVGCSSGPEACASDTPSVKPCDPSTMALLCRRNQKQAYDDFARPYRTSLGGAQVSPEATGAPEAPDATGERRDLEMLTPRVYPVASRVLEKESDVWEKVADILGELHDKMVSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ05</accession>
    <name>F9WJ05_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_21340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002668">
        <property type="protein sequence ID" value="CCD17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21340"/>
    <dbReference type="OrthoDB" id="1731805at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394810" evidence="2">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="18970" checksum="FAAFB4992B0E0272" modified="2011-10-19" version="1">MRARTSALLISVLSSFGALFPHVPASFAKDAPLLTGGLLQWVPHVACLVAPFLDLPHLTHPIPAAHTLQFPLEHGKPHVPATLSSPPLLSAAASSAASSAAMHGGSSGSVAPPCLPIRCRSMLAHALSSHLHTRHANSPLAFGPRPLEDRGCPSPPPPPQLTFLSVLGVSLATAISTTGTPQMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA0</accession>
    <name>F9WJA0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22250"/>
    <dbReference type="OMA" id="CECHAQL"/>
    <dbReference type="OrthoDB" id="1654494at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="824" mass="92615" checksum="A302B56A3A157ED8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI3</accession>
    <name>F9WJI3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 914</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002729">
        <property type="protein sequence ID" value="CCD17488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23060"/>
    <dbReference type="OrthoDB" id="1729784at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031083">
        <property type="entry name" value="YTHDC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF100">
        <property type="entry name" value="PTHR18934:SF100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17803" checksum="9492C8CB260DDF88" modified="2011-10-19" version="1">MTLRKHQRSREAQGGYLATFKRTIQTKGYQGLQRLIAPRVEYMGEVIDGLTRLLCHRMTCEVKPSDEGVHESYPLAITRCGLKSIPQCTMPEKRFRFLKEFRRSLPSYRHKDVIVESVRRGAVVVISGGAGCGKTTQIPQMLYDEEGLFDKNLQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJN7</accession>
    <name>F9WJN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002750">
        <property type="protein sequence ID" value="CCD17544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23580"/>
    <dbReference type="OrthoDB" id="1664081at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="48415" checksum="A069FAB0DF5C0437" modified="2011-10-19" version="1">MSNSPEEERPLPTPEDEQRRATVLQMIEDNIAMAQHGEVMTASLQKMSEGLSRQQATMPQTHTPVVPCTISTPSDSSTLLQSPQTNSTQLPSPSARPPRPPVAPTSATRQTVSPTSRTRSMGQGLQGSIPLYSEGHRVRLEECDKVGSTILKQLCCENPDMVESRYNSEDGFPRCFLRQVRNSADARPLNMPDIPIGTEIISPFGSRRMVLDQIRQRRTAIQVLEAEITGQRVVNLHNTRTDLRTFQCLDAPDVEFTTEMQVALRSFTGTLFILERYGPAITVEGIIKTYGATWGDHLKWMGRIDDTGNPIRGADATGRYDNYRTAFQAVCYWADHHERTICALAGPLAHQVVTFSPNDYNDMCSAFTTYVIILVGKIHAGKRINPSQIRQRYMQGITDELQDTIDEHLNSFIQRKYNRTGRNRRPLQPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR4</accession>
    <name>F9WJR4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 940</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002758">
        <property type="protein sequence ID" value="CCD17572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23830"/>
    <dbReference type="OMA" id="HMEPEAG"/>
    <dbReference type="OrthoDB" id="42865at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="PTHR13326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="580"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="817" mass="91036" checksum="B6C19357E370931D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX2</accession>
    <name>F9WJX2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002783">
        <property type="protein sequence ID" value="CCD17632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24380"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21096" checksum="959E14B5D03ADC7C" modified="2011-10-19" version="1">MDSRLTKFDPRNIHRNIKAFTDYYCTALRRHCPRGMVKDGPIFWDREIIEAERYVETLKSRYLNMPSSAQLAVLHEAKDKFMDTVRQRLNTTLRHRLGKLSPGEHLSWKYISSRNRATIPLADSLLLSVGNKQLSNSRHIASAFNGKFFPHFKIGQGYLGLLPEGLLKEVRKVRLSLLLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY2</accession>
    <name>F9WJY2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 96</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002787">
        <property type="protein sequence ID" value="CCD17642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02570"/>
    <dbReference type="OMA" id="TNNSVRT"/>
    <dbReference type="OrthoDB" id="982374at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="355" mass="37692" checksum="2608AB33E0C7E025" modified="2011-10-19" version="1">MISAPAVKELLSSVKYVLLDVDGVVWSGPLVLPKIPETLRYLRSIGKQVRFVTNNASISRASLAKKFKDRGIEGVQVSDVYNSGYAAALRLRSICGGEDGLVRENIFVVGEEGLHDELRQMLAPGYVTYGLELHDAEAVGGYNSAVVASAWKENVLRPPQQEPELLPSGEACKTNISLADLSPGAVVVGLDTHFNMLKLSYASLCLQKNRRRSCTAHDGGKAQKHVHFIATNMDPQIPIGEEGVLLPGAGSMVAAVSTASGRQPDVVCGKPCVDLAKALFEAEGITDPRQCLMVGDRLTTDIAFGNAAGCRTLLVLSGVESLEDVARVEGEGNGNLLPEFIAPSLAVLLPGGCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY9</accession>
    <name>F9WJY9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_24540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002791">
        <property type="protein sequence ID" value="CCD17650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14788" checksum="1F0E34BBBFC15C73" modified="2011-10-19" version="1">MSLRTVLDRITQGGHYSQAAQVMSDVDIIWSNCEKYNGVESTLAVEARKCKAILADNLERLEGERPAPGAEVDRLVTMLDGVDESVLAALEAYFKREDPTLILGTGDVDLSLLRVKHVRAMKEIVEQAMNGDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJZ0</accession>
    <name>F9WJZ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_11_10570</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24550</name>
        <name evidence="1" type="ORF">TCIL3000_11_10570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002791">
        <property type="protein sequence ID" value="CCD17651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.10570"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24550"/>
    <dbReference type="OMA" id="HQKKRAQ"/>
    <dbReference type="OrthoDB" id="1299258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC95584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="21434" checksum="88CCCF440A1EEE92" modified="2011-10-19" version="1">MLRLCRVSLRVQSHQKKRAQHPNAGTRFGRVYNRGFIRYGFGGFGMSVYTPKKDRRFRVQQLPPPPTNSFADDVSLVSTTRTLSPNFRAFALQDGGVFFTHPSHEQIMRVGQGILAEETKATGMTSMDNYVNSRIQSIIAENTVENVALSHWRRRHMWNLVKTHGKLQRHWGVSEATKGARSNIYGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK10</accession>
    <name>F9WK10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 97</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02650"/>
    <dbReference type="OMA" id="MCKITED"/>
    <dbReference type="OrthoDB" id="315731at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="598" mass="66554" checksum="8BCBCFC4A9EFFE4D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3J9</accession>
    <name>F9W3J9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1064</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000423">
        <property type="protein sequence ID" value="CCD11718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26720"/>
    <dbReference type="OrthoDB" id="1589300at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="285" mass="32416" checksum="8FF100CA97FD2ECC" modified="2011-10-19" version="1">MAAMYDLDESRLRRIRRLPPSKEGVDVGGSASSMQALIPEEGDLLTCEFTGEKYQYSGLVLWSSSRLLLLICTVRDATLCGRQHDSYLSRLALRAKQSLLNLLTEKALQSQLEFAWERFRKNAFAGDGAEDTEEGDALHCLRVLQTRSVKFSLHNFMEPFLHINVNWRDLLSNARRNLWYSYEPDYALHLINVHGAQTSAERPDEVNDVQEGLILTLGACGLGEEYLVAIEFDSHRKCDVIKTAALYRHANDRSSAHTAMTDRELQLVECVLRLLSSALWNHEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y1</accession>
    <name>F9W3Y1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000492">
        <property type="protein sequence ID" value="CCD11859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27990"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="22163" checksum="A53776D6F98DBEAA" modified="2011-10-19" version="1">MEVIAPSKSVRVLLARGKARWDEFRLISDKPTSQRMKRSVKGVDAPNEAVKKGVRQAAKKAIRKGSGVVQPFWTPELTKLKVMVQQCRNERKRDARIRWRSKVPEDTAIRRWEDNVSKLSTMDTISWNLVESIYVPRPLPSPVLVVDGHPRTKRRQAQALARMYRERLMKAPKAPDMQIPSTSHGTFKPTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W437</accession>
    <name>F9W437_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000510">
        <property type="protein sequence ID" value="CCD11920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28560"/>
    <dbReference type="OMA" id="EEQRMSS"/>
    <dbReference type="OrthoDB" id="1681940at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="629" mass="75998" checksum="1D31E1E9D8D50D4C" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W486</accession>
    <name>F9W486_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_29000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000529">
        <property type="protein sequence ID" value="CCD11974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29000"/>
    <dbReference type="OrthoDB" id="111568at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="595" mass="65686" checksum="3C234F4E6D6342F7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4C5</accession>
    <name>F9W4C5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_29350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000540">
        <property type="protein sequence ID" value="CCD12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29350"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="80"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="43959" checksum="1E3E24A2EDCB98FD" modified="2011-10-19" version="1">MSPATVKKVLFFTKLCLLKEIVLKSSSYKEVKMRMKVLLLMLTVGGQYLEACAARIDVYKHLCEITRNVVALLGLHRNRSALRDAIYGKKGRAIFDEEGIVTVQEHCGGVPSGRAILCNHFKGDLPGNAQDGCLAESLLGTFMCVCAPGGREAKMLCGMEPWKADGTWWGGFLAKQNREKLFRDVWRKLIGKCLVESEIHTSTEINLKSLETSLKAIRESLRSSASGGTNYFYLGEPEVTSCSGGVNSGEGICASYRGGLLETKHSVKIPWLSEIEKTTNELLGKITEPSSESHGQVDPSFSEKKANIPIPAAANEAPEENEALKPVNIAAKGNIQLKNIQPEPQVNESMQITNLAKPEEKRKPTKYNVVDIPHLAIDPNEDFSILTNQKWLLLSILFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J1</accession>
    <name>F9W4J1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 118</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000561">
        <property type="protein sequence ID" value="CCD12085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03070"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="786" mass="86682" checksum="1AAD556192AE7370" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P3</accession>
    <name>F9W4P3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1208</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000584">
        <property type="protein sequence ID" value="CCD12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30500"/>
    <dbReference type="OMA" id="WGAYLNR"/>
    <dbReference type="OrthoDB" id="1006406at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="PTHR11927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39221" checksum="26A73016128A9ADB" modified="2011-10-19" version="1">MLLIFFSSFSSTLFCSFYAYIMHFATCDLVFAKFCRMKAGISGSKTFVTTNLVGGLGNQLFLVANLLATARRNGLTAVLPRVGFSSSNEHPRPVYWKSVFADLEAYGVGCELPADAPEVIVPEQRPVSPVTISASTRCTYNMVGFFQSEGFFADHPIIRDVVPSEMRNASLKHLHDNYKTKNSDPRVTQYVGLHIRRGDYLRLGDVFEILEVDYYDTAVRQLLGHALHQQALGQSHVHLLVFCEEERYGASVVGYFRSKYAGLEASLVSHSVESVGFSCDEKMPREVLELLMLSNCNDIIMANSTWSWWAAYLNTRPLRRIVAPSRWFVQHPYPQSNHLYCSNWILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W518</accession>
    <name>F9W518_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1264</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_31650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000645">
        <property type="protein sequence ID" value="CCD12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31650"/>
    <dbReference type="OrthoDB" id="1666689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388686" evidence="8">
        <location>
            <begin position="29"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="9">
        <location>
            <begin position="164"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="222"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="42160" checksum="4770BCFBEB0BCBC0" modified="2011-10-19" version="1">MKLLFGMKMKAVVLGIVVVSMGMSVGSGSNANGFHVLGEVLRRAERVMNETDTHSGPLKEALYGMPDRHSFSVWDPVTMKSDCRTMRLRNLLCTYNSVTSGCFAESVAGSLTCTLEKWNGHFQNAGNQARDKCLLGSDNMEGTHKDSMRSLEEAVKEVRYTVEKGSMHGRTLFYLGEGMGLNGCSGSRRNDACAGCHGVGKTRDNVPIPWLDAIKKVIPDLRKAPPRDAIPPKTTAPTARTSPTLKGPEALKNPDPPRALRHPHSNGHHSKGAYGRNPHTRYSITKIPTQVIEHLPEDTSTTDEPGILDPTAAPFSLPEGADILTPLWLFPCPPLALYTNETLPCMKTGGFGRGSYLATCTAPRVRQLPVRVLAWWSATQRSGRQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W543</accession>
    <name>F9W543_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31870"/>
    <dbReference type="OrthoDB" id="1718956at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="19153" checksum="FB1AD2C0D086BCA4" modified="2011-10-19" version="1">MPRELAALIYFLHLQPLDWHSGQPKHHAGRFGGVHNFSHLPRSRISRAGKVLLSFSIGTPHPNEELVTCKGLRQISRHFLLMSREAASDSDVTVWQPLSPSCFRLFAFGALRALGASPTPFRVSVSEVQRRQKRCSLGSFHWDVPRSLQQKAPQWQGGEIWRPFDWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W552</accession>
    <name>F9W552_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1276</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000659">
        <property type="protein sequence ID" value="CCD12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31930"/>
    <dbReference type="OMA" id="ELELYIA"/>
    <dbReference type="OrthoDB" id="984892at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="327" mass="35998" checksum="F7667E2CDA6E8E8B" modified="2011-10-19" version="1">MASTGADNTTTDKRNQVALFKKVNQLQKLCIRHGRSLCTQQQNLVQLNITCATLSERQSAAERQLDHFSSIIPNMLDSKETPRFVGDELPADDMTATELELYIAHSSAAVRNLERDISEQNSILGRKKRKLADLHEKYQAAVSRSRKRCRTSEGSKCEERGRTRDSGLSALLSSSDAEGDLRPSKLRENRPSFVLVDSHENSTANDQQPFIISSGESSDVEEVARNGSGGGEREVVIIEDSPARSLVSGGSTPRRISARGSEQRGQSENFRGASGGVPGELGSEEDVTWFSRAQRVRSTIQNVLIPNVARILPRRVDRLFQSSLGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9W562</accession>
    <name>F9W562_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000662">
        <property type="protein sequence ID" value="CCD12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32030"/>
    <dbReference type="OrthoDB" id="594840at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="161"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36563" checksum="044E7A355A58E3EC" modified="2011-10-19" version="1" fragment="single">MPIYCVAHATRRFSAFRTIGDELIPQPCLAGTSLFHQRVRMCSASSPRWIGAASGQFRSGAVVARDNGCNAVVRVKRLPLTLIEEVPLPQRILTDLELVMMAWCEEHARQYAIIMTAIRLGMFILLLIVLYVFYRTQISSERMLRGVDHMPPDLRVGSVVYFDVTENGVDIGRIVIGLLNENCPHYCEYFHRRCTGNGGRGDSFRGMHLSAIVPRHCLIFGDGREMTHDVPGFNPHYLPTEFVGTGAWRGALSSIAYGPNKESPNFTIHVSSGDYTPQVFALVLGGYDVVERINSAGSKHGNAPKKEFVIVECGELCTLAKSHITPIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5A4</accession>
    <name>F9W5A4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000686">
        <property type="protein sequence ID" value="CCD12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16189" checksum="0D7C7BED21035FD6" modified="2011-10-19" version="1">MYSGISSAVARGSTKDANSDSAASVSSPKQYSSMDCTCSNFWRNRKLLMYLTRISFPVIFNCVIKDLCSKYVAERCHSCLQSAIAIPISDEAAKRKRVRLSIPVNMIISWPMISTMDMMPSITHEFLNDFQSDSLILLAFSQPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B4</accession>
    <name>F9W5B4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000689">
        <property type="protein sequence ID" value="CCD12363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32480"/>
    <dbReference type="OrthoDB" id="1732240at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16668" checksum="369FFA044C5247DA" modified="2011-10-19" version="1">MRRGGLQTGLGWRVDSSRFRFRDRGGSCPDASPACGRLRGMHDFTGFVVWNSLMLRWSTEKKRGVVGRNVFRGHKVVCWKPGSRGVWNLSHMKSLSIDIPKKQANKRVHEDLGVGRGSPIPYSLVVIFCDACPVGISCLGGAGAGGERLVSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I0</accession>
    <name>F9W5I0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000715">
        <property type="protein sequence ID" value="CCD12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389817" evidence="1">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14767" checksum="EBE8C89196DAC413" modified="2011-10-19" version="1">MVCGWAVQNALLPLKVFAIPTGPKFPVPQKSFPIFKIPPPHESGVLTFTPTFTPLAPLIRLHPAVLSYFLLKYVTRLMCAIRSTTAVRFVSLPFIVTPWIFAQLCSSISELLPVGKHSNKFPLFAVTLPPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R4</accession>
    <name>F9W5R4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_33890</name>
        <name evidence="4" type="ORF">TCIL3000_6_1550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575319">
        <property type="protein sequence ID" value="CCC90921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000753">
        <property type="protein sequence ID" value="CCD12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33890"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_6_1550"/>
    <dbReference type="OMA" id="AENCMRY"/>
    <dbReference type="OrthoDB" id="1421503at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="PTHR18847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="42"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC90921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21098" checksum="16398800D0712D4E" modified="2011-10-19" version="1">MAEYLVDMTPRMAYVDRHELLRSLLTEKEFVERRQVQLDKSTTVYVGNLSFYTTEEQIWEYFSGCGHVRDVVMGLSDVTRTPCGFCFIVFEGQDGAMSAVSDLHGTLLDDRVITVSWDVGCDHARRWGRGAHGGQVVDGVRQNLDIARGGLGALRREELGVGAAVAEDQLVQYTWVAPRRVEKRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5T4</accession>
    <name>F9W5T4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1374</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000767">
        <property type="protein sequence ID" value="CCD12537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34090"/>
    <dbReference type="OrthoDB" id="69022at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="PTHR12975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="250" mass="27880" checksum="33770876EC6EC9EB" modified="2011-10-19" version="1">MEDKLRACYKGQMQGSSVGSRYSGQDFIKIKQLIKKDNNGNIIKALQRYVMNQEETLQVSVVLRNPIGVPLTVSNISVLFISKKDPTKLCRTADSRTVSLKALASDSVTIDFTPTDEGTYVIVGFSWEVLGVVGHYYFATESGSLTPNAGDGNKGEGSHPGVRDSMLFEYAMKNPMPDVESPANIEISVGSPQAWVTMHLQPDIPPMLRDGEYFYTQWLLQTRVRTLLLTISHYSVAHKMRIYYGLRSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5V7</accession>
    <name>F9W5V7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1387</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000781">
        <property type="protein sequence ID" value="CCD12560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34290"/>
    <dbReference type="OrthoDB" id="1736383at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17730" checksum="EA45358BBD448450" modified="2011-10-19" version="1">MGRGSYVAGSKGLPHQRSNRMDYCVKVFHVTATGHRPACSTRDSLPLLFITCGGGLVLCGAWLAAHFAQRVRYPHVFCRIHYISDCMKHPCRAASRSYARSVRTPRRIRKDKRRNCLFHVVSRRVSEEAKFVKSSRTELRRVVQSRKHHARRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W603</accession>
    <name>F9W603_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_34720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000805">
        <property type="protein sequence ID" value="CCD12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34720"/>
    <dbReference type="OMA" id="IWRTEDY"/>
    <dbReference type="OrthoDB" id="307139at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="35097" checksum="E24D511838535253" modified="2011-10-19" version="1">MLVEKPAVLFRARKSRISVYMLPLMTLLALAMVGYTLYGIGNGDHTPEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDIDGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVIILPTSDVRPSTRKRIGEGGSWGLAAEIVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRLNTYTRFWRSGALRYTLGYCTTLSKDVAQAVVSIQAFEARGAHTDTHFKLFSIPRPCNVLRGRHGGPCATGENKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-08-12" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W667</accession>
    <name>F9W667_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000827">
        <property type="protein sequence ID" value="CCD12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="200"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="463" mass="51453" checksum="2443309E03999DD9" modified="2011-10-19" version="1">MKRSAKGADALNEAVIPGIRMAAKRTIPKGKGVAPPFWTPELTKLDKMVQECMNERKRCTDPRWRRKVLVDTAMGRWKENVLKLSTTDSASWNLVKSIYAPRPLTSPVLVVDGHPLTKRQQAQALAKMYMARSTKAPHAPEMRIPSTRRSTFRPITEAELDVALRELSSGTAPGDNKIHCEELKELGRVAKKCVLRLFNCSLCTGQVPAKWKHGIIVPLLKPNKPASSMASFRPVTLTSTLCKLMERIVARRVRDCVEDKLQPQQAGFRPARSTLDALMQVTSAVRRRRDGEKTAAVFIDYARAFDSVDHDCIVKALMSFGVEKHLVAWIADFLKGRTAQVRVNNTLSEDISLTCGVPQGSALGPLLFIVTVDSLSKRLNCIPGLQHGFFADDLTMVCTSADLSAIQQTTQHGLDCITSWSEEQFMEASAERTVYTLFGSRDKNMLKLEVGGTAVNEHDCENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W668</accession>
    <name>F9W668_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endo/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000827">
        <property type="protein sequence ID" value="CCD12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14556" checksum="DA929FF9BA8974CC" modified="2011-10-19" version="1">MIISAYFSRKADVSSEALDTLLGANGAMVIGADVNSHHVLWDPLRPSDDKGECIVDWCVQNDRRIANTGLATRRQPGTAALSLPDTTLCRDCEISNWKSSLSPDSDHHWITFDVFVGTSLDVIAPSKPVRALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I2</accession>
    <name>F9W6I2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1473</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_36380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000877">
        <property type="protein sequence ID" value="CCD12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36380"/>
    <dbReference type="OrthoDB" id="160280at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="366"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="408"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="655" mass="72663" checksum="98079E05B1607745" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N6</accession>
    <name>F9W6N6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1493</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_36840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000900">
        <property type="protein sequence ID" value="CCD12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36840"/>
    <dbReference type="OMA" id="VVWWGFD"/>
    <dbReference type="OrthoDB" id="464928at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="85"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="38461" checksum="5E65D48F09AC5798" modified="2011-10-19" version="1">MESYYTMQGYDTKFAFDVLHIRFSDKEMKPKESRSESSPLLGGADFPCSNALEGGKGNSADGEKVTDRSASSAHIKHLRNAGFDLFVFGYGAVVWWGFDQRFFKIVENDFMLPNSPISVYMINRYATQLVNGNYPVWCTFNLARKESLEPDEHFREQLRFDHFLIPCGRGDLSTGNVCMLCVSHALAQSAKIDYLELKVQGLAEKCSPLPLELREKGRVTITERKLLQLRGEVLSYRLMLKSGSNLMDEPDFFWENAYLKPVFQATKECFEVAERVEALDNKLDAANEILSMIAEEFSQRHGARLEWIVIWLVFVEVVLGVLELIINIKPWRDAIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6V8</accession>
    <name>F9W6V8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000942">
        <property type="protein sequence ID" value="CCD12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03770"/>
    <dbReference type="OrthoDB" id="1714262at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18142" checksum="9703B29D64A8B42F" modified="2011-10-19" version="1">MAHSPCTPHIAGIGNSSAVTLPSVLACCSSSILRSTVHTSTPQPSQPPFNRIVRSSSHTATQTALTAQSHFNENYPTGIPRPSQTNTHTRMSPNDTHNKQELLIPSEATGRTPTAHEATQTCRDYMQPRPGNLCFLHVLGNCTPVKHVFQAACICSFGCSCCRTMHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W713</accession>
    <name>F9W713_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_37900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000960">
        <property type="protein sequence ID" value="CCD12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37900"/>
    <dbReference type="OMA" id="WRWYTPP"/>
    <dbReference type="OrthoDB" id="612803at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="541"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="920" mass="103388" checksum="183B51CE797DC1C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W720</accession>
    <name>F9W720_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_37970</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000965">
        <property type="protein sequence ID" value="CCD12979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37970"/>
    <dbReference type="OrthoDB" id="1675788at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389947" evidence="9">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="30"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43175" checksum="2AE538E41B9BC97B" modified="2011-10-19" version="1">MLVELYSKYWWLASVTILLSPEAALCSSPKAIPTKAAAAICTLSKTLKDITPWATQQVEDGAAKITHLEMKLLEWQSKFLQSKSKGSGWEACKITSLLFRQLRKEIEKTREEVEKLEKEASKAAAFAANSAGRLDEFITVFANAQGSSKYCLGSDKAAKPGDLRGCFSKNDFGEESLVDISERAGEQEPNLDSKIDGIKHSKLSSHFTGSSSTTEAGCNLIKGTKQGILENTELEKSLWWGGGILTIGKGFRGEFNGSFKPGEIPAATKDKATWTADPATQVVHLKNASDAFKAFKAVQEKIKEKVESIEQKIQACMGVQESGENGTEQNITEPAAPLSPPTLPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPNSAFNAKITANHFVILLILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7H4</accession>
    <name>F9W7H4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001033">
        <property type="protein sequence ID" value="CCD13140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04280"/>
    <dbReference type="OrthoDB" id="1655958at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="637" mass="66467" checksum="78B935D3F60775DC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7L8</accession>
    <name>F9W7L8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001050">
        <property type="protein sequence ID" value="CCD13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39600"/>
    <dbReference type="OMA" id="WLPALCK"/>
    <dbReference type="OrthoDB" id="1200503at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_L7A/L8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="5">
        <location>
            <begin position="141"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="31153" checksum="F7B4E5C7338C551C" modified="2011-10-19" version="1">MPGKEVKRAAKPVVKSKAPYKKPAAPQKKAKTASAPSPYVARPKDFGIGRDVPYARDLSRFMRWPTFVTMQRKKRVLQRRLKVPPALNQFTKVLDRTSRNELLKLVKKYAPETRKARRERLKRVAEEKKKNPTKTMSTKAPLSVVTGLQEVTRTIEKKTARLVLIANNVDPIELVLWMPTLCRANKIPYAIVKDKARLGDAIGQKTATCVSFTDVNAEDVAALKNLTRSVNARFLSRSDLIRRQWGGLQLSLRSRAELRKKRARTAGNDAAAKTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q3</accession>
    <name>F9W7Q3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001064">
        <property type="protein sequence ID" value="CCD13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39950"/>
    <dbReference type="OrthoDB" id="1738072at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17723" checksum="D93BA6AFC9E1BED9" modified="2011-10-19" version="1">MNMYQSVFRPTSAQTQTRAYLHWPLSREGGCVALSQPLLNQLIYAYTQLCRVVRNQRRQFLSLFPPFFPNDVERPAMRMGQLIFYFNAFLSFFFLIFIFLFLCIACSALEFMDGSVGPNRTGRARGEEEIMCVVKGYSFLVYLDEPAHDTKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V2</accession>
    <name>F9W7V2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1658</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001084">
        <property type="protein sequence ID" value="CCD13274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40430"/>
    <dbReference type="OMA" id="RSACEMS"/>
    <dbReference type="OrthoDB" id="978394at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="414" mass="45874" checksum="6F04B8E76066D964" modified="2011-10-19" version="1">MHCRGLLSSRLHLIFSLFPTRYCVPVLLLHVSYVVSLRSLMKNTAKQFRGVGDVLRALQTRGEWLGRNACVFFVGGPWHGAVRTWIVDHLHNCSHVKEGSCSTFPPKREANACLTLNDETTKKTSFLRSLVGDVGGDEDVESPSFCLFPRLGSGAYSQIGVAGRTYELPFTVAEAAAHVRRQPGLFQAGGHFDRNRLLPRITGDQNVSSSAAHDCMNVFLRHHTADLIALDLDGEPAMEFASQCPAALTDYVEDIRNSLALSAYLLKPSGALLLRFPLYAMTNGVEEFRVLMRHMNCRFQVSAHEIEGGYVYYMGCRSLAYDIPPAPHTTSFRHPADKPKGRFIKQSQRARANAPYFSALMPSYTNASRVKEQLESASLSTGEATGSAEVNAEAFFNMSVEMAEQGLHNHKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9W863</accession>
    <name>F9W863_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1709</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_41470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001140">
        <property type="protein sequence ID" value="CCD13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41470"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="482152at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="PTHR11353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="544" mass="59600" checksum="D84C54859ED017F8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W872</accession>
    <name>F9W872_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001144">
        <property type="protein sequence ID" value="CCD13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04450"/>
    <dbReference type="OrthoDB" id="154101at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="510" mass="56213" checksum="5C523986F694031F" modified="2011-10-19" version="1">MVVILSFICEWSNYMCERREMLDGSARCRNGDDPAVARCKEGVVKMLSTLCVRRSVDLSTNAGIGVMGKVYKGAVRCLIALMRMPELQDLNVLRELVKKLCEHVNKAKSEASCNLVCWLKALTALAKDRTTARMESTLLMKSVTAILITAQSNAEVADEAHMKTKASELPSMTTAGAVVDAAAKCLTAIAMSSPSEDMGKATDATLNTLLNTCDQVEKSDQHTVGACLRRCSIKQQLLRLVIRPPPNIGSEVAVAVALSTETETVVRRVIQSKMTFNILNRKCDVRYVAYLILTAVAEDSRSGYLHLRNLLFRTGTYLRTKQEAPGVTLSSPTAWDCFIEYSIPFLVLFMAHHPYYDVEKTHFTSFQRVWHLLFDELFRYGVHCASFVTEMLNRIKQTDDPLNSESNAMRTMCDLGIRVMQECMGQRQISTDALRRYPGAVSLPSFFVGSSSTQEALDKVYLDPSVLISAKVPFRPPVTPGGGTMPGGAPSAPNVAGGEEDEEDAMESDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W899</accession>
    <name>F9W899_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001152">
        <property type="protein sequence ID" value="CCD13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41790"/>
    <dbReference type="OrthoDB" id="1745671at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16977" checksum="21F95204CDEF45EE" modified="2011-10-19" version="1">MTGLKSDFDQSKRALLEHLQELEKINTYYTLEERMLLGVVVNEVARENENFYRAFEEASTHFREHWNKAKTALKKALGKKGEGSSVNCNETMSALSQFIRCHVTGGRNRTSPDTTTTLGTVCKGQGTRQHLKQSTGDTILETPLEAAWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D4</accession>
    <name>F9W8D4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42150"/>
    <dbReference type="OrthoDB" id="1728734at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="16798" checksum="3C39E53F541B93C4" modified="2011-10-19" version="1">MLYAYAREDTVETMSNCGVTSELHAAHCEGACVRPVCAGHGGCVWTLDSTVEEVLLWKYGNVTEAHLHKFLLDHFGSTFGLPDMSLIAFMNDPSLFVTDTQVLSGITSSAAYVDLQAMLRAVNVLNSAGIITLEQWSALSDAPAVVERAAATATSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8E0</accession>
    <name>F9W8E0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_42210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42210"/>
    <dbReference type="OrthoDB" id="1665978at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389951" evidence="3">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="423" mass="45822" checksum="CF17AFF51DE1A964" modified="2011-10-19" version="1">MRVYGLVFVCLSWLALLSGVASSSNDNNGVCKLGDEAAAVLCAIAHLVEKAKEVAHNYDHKGAEDALGYVKLHKEQLDHRKTRLEELLEEAKTKGTLTPEQADKLKGAAGEAQKKNDEEHKRATEVMANYTAHHDKTKNVTITARGETLTRQSCLSTASLIDVLQCHVQGKIPDGNKEIIETICRGKGYEKHISEPLKNNLEGCKGIGGSKKYCNGTGAALKEVLEKWGKVEKAAGGNQCDVKKDWEKYAHEAKDHMLTLDHILETVHSAKELTTAYLSTVHKMKDDVEKGKPMKEILENARKAGKEGAVVLVAKPHPSTGENATAASETGGSDKVEEEVKVNVKLDGLQFDEDESSLANSKDKFPKYYVYLLAVLVPVCSIALAAAIFCIIRRTKPAHAEKGIPVEGAAAGKSQDGGKTASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8E4</accession>
    <name>F9W8E4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="16661" checksum="6B56FDAF781EA3F8" modified="2011-10-19" version="1">MFHYLLFPYFLSFLVWRLRKSSENNQWSGRRLTYSHAATATRIAAWRVVSKLLKRCIVSLLFMLLYLFRYLLLLFFSSLFHRAYVMRVVAMARHAFTFYGLFFLWRLELTLACNAVTFTRYFVCILTLWVCVGIFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8H0</accession>
    <name>F9W8H0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42480"/>
    <dbReference type="OMA" id="PTACEDW"/>
    <dbReference type="OrthoDB" id="589910at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="385" mass="43657" checksum="F714C4A87690472A" modified="2011-10-19" version="1">MSELVPTRCVDWSLNTDTASGKTFLWHNQYSISIWSDTLGFIRPYDDLDDTAVWKAFMWFGVNTVFKLCVVCRQPDGVEDMMICCYCGRTVHCECSMEATEDQIACKEANCEFVSYLRVCNSCGGVGVTPTPTRGRGGTDARKAIWRALTIRDEYPKNIVEGLELLRGKANAPHTKEEDKRLLSEVRTTVGRFFQPRGTTQLFEKVAREGKGGVGIVAVKDVPAFTIVGVYPGYGDALGGEHAKLGRPIPKYALMDLNCADYFNVVFEEFQDTFTPFINEPDKGEKSNCGWIQETKYRDGRLSVMTCRDVSKGEELLIGYGPVYPRDYPFTYDAFTFYQTKSKRYRVCFALWHWPTVDAKDAVLEHHVEFDEASNSYHLVDFDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8V6</accession>
    <name>F9W8V6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1785</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001225">
        <property type="protein sequence ID" value="CCD13642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43800"/>
    <dbReference type="OrthoDB" id="73829at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20602" checksum="F4A9A33EBEBCD406" modified="2011-10-19" version="1" fragment="single">MILLFTVFVRAYKGMQSAYTIRVSERQSDGVRDVAVLHHGELHFSTSHRNMKWAFLTRFPAPSTQHGGSSLSAEDSLPGDRCDDTAGFRDDDKLQDQTHVGRDYGASRERVMHEYLCVFHLEEPRNCLSNYTAHQLCTICSAYSTVDPGAVTHFVLNNINPSCVVPATRGVFVHGMPQASVSPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Z6</accession>
    <name>F9W8Z6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1804</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001246">
        <property type="protein sequence ID" value="CCD13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44190"/>
    <dbReference type="OMA" id="PEIMIEV"/>
    <dbReference type="OrthoDB" id="1406129at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="23975" checksum="E7A54722524617E0" modified="2011-10-19" version="1">MQIDYFLPFFSFIIFHEHIPYSLFTCSLPTGNVLVNQLMNKVGGEKSAQGAVGAPPVTRKRIRFVQDRNVVHHVKPPPRSMNSQFWFSEKAATVLRGLTLEVCPGEDMFVVVETEMHLTSITLSPAEPKCPGNGGLSNESKPHGGHKSGRSFLQIKEENTFLRQATCGKWMCLGSVAEGTAEKLHVRLPAGSYMLRCVGTRSIQVFAQLLDLTSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W981</accession>
    <name>F9W981_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001277">
        <property type="protein sequence ID" value="CCD13772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04840"/>
    <dbReference type="OMA" id="LFIAWDE"/>
    <dbReference type="OrthoDB" id="1530131at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="23473" checksum="853BFA4DDFCDD587" modified="2011-10-19" version="1">MATKVTKGKGTGKKNTNKVKVGGALDKAHLVSSFSFCEVKKQQASVLFTAWDEEGDGRISQQHLIAIIYALFPPNNSLEEVTTNYSALTLYEIRRAFLLAAGRPLSAGQYVTLKDVLGVIDELWATTDVRERMVQGCLYHVFTVMANTDCLITRQGLLETCNRATGCSISKAAIDAIVQKYSVAYDTAGERKEADKYLDFDGFCRIMVPLLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W987</accession>
    <name>F9W987_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001280">
        <property type="protein sequence ID" value="CCD13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44790"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388860" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22884" checksum="E672A9E2EBB70540" modified="2011-10-19" version="1">MPPLYTILSFLLLIPFLSPSPIGITMSNTPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPKKINLYRFLQPAYPLIHSYISRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K9</accession>
    <name>F9W9K9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46010"/>
    <dbReference type="OMA" id="VRSRTWP"/>
    <dbReference type="OrthoDB" id="138195at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="264" mass="29410" checksum="65D8AE79DB4A80B9" modified="2011-10-19" version="1" fragment="single">MSDASVDEVYEPLLASGGDVVDVTGNISDDATCRNGATTEVCIEEAPAVETGSTIDGLLQAEQRHNTRRHLWRAQVHALLGPEPPYAVQPEDRAGCLFGRLYYTWVGPLISRAARGATLTPEDIPRPARDARAFNSGLRLLTALEEQKFRRHGWDEFAAEGHGAALVRHRRDSASVGLLRWVGPVQQLRRPQEVYAGVEWKVPPKHRVKERKRNARKHKKRRGRRSEGEGDVMPFHNGVIYGEHLFTTSNGEATATCEYVCDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U3</accession>
    <name>F9W9U3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1898</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46810a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001350">
        <property type="protein sequence ID" value="CCD13998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46810a"/>
    <dbReference type="OMA" id="RCHRAMG"/>
    <dbReference type="OrthoDB" id="479815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="659"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1098" mass="120724" checksum="527973033FBBBC77" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9W1</accession>
    <name>F9W9W1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1905</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_46960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001358">
        <property type="protein sequence ID" value="CCD14016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46960"/>
    <dbReference type="OMA" id="LECCKGT"/>
    <dbReference type="OrthoDB" id="693214at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="401" mass="46200" checksum="CD1647794304359A" modified="2011-10-19" version="1">MEKRVRQLTRCCEDDSTSAEAQLALLDAQESLQLYVTEFTALGNSIQSLRQKQSDLSQEKKFFCKEIRRVNEEEASNFSAVEAIGQHDRYVLMHLLGKGGFSEVWKAFDLKEARYVACKIHHVQREWSPQVQQHYRSRVVRELSIMRKVEHPHLTRLYDVFEHGPTTFVAVMEYSGGMDLDTRLKRYGTLREADARLIVLQIVSALRYFAAQEQPIIHYDLKPANILFHCNNSTSVEIKITDFGLSKILPKRGGPNDDPTIELTSQGAGTYWYLPPECFETTATPRISNKVDVWSCGVIFYQMLFGRRPFAEGESQGQIWQNKLIISSARTLRFPDTPRVSQEAKDLIQKCLEYSPADRYDVVQLSQDAYLQRNTRRYTRTTERIVPPAAPRLETLPQPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9W9</accession>
    <name>F9W9W9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1907</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001360">
        <property type="protein sequence ID" value="CCD14024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47040"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="27228" checksum="660B57A0E058F0A2" modified="2011-10-19" version="1">MEVIAPSKSVRVLLARGKARWDEFRLISDKPTSQRMKRSVKGVDAPNEAVKKGVRQAAKKAIHKGSGVVQPFWTPELTKLKVMVQQCRNERKRDARIRWRSKVPEDTAIRLWEDNVSKLSTMDTISWNLVESIDAPRPLPSPVLVVDGHPLTKRRQAQALARMYRERLTKAPKAPYMQISSTAPGMRHLSQLWKHNWKQRRESPQEAQLGEMTEFIPKSSNTWVGLTGSAYFDYSITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI9</accession>
    <name>F9WAI9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1979</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001440">
        <property type="protein sequence ID" value="CCD14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49000"/>
    <dbReference type="OMA" id="NGPRYCA"/>
    <dbReference type="OrthoDB" id="985292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="545" mass="59996" checksum="C975744C8425D0B2" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAM6</accession>
    <name>F9WAM6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001454">
        <property type="protein sequence ID" value="CCD14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05330"/>
    <dbReference type="OMA" id="PVEREVC"/>
    <dbReference type="OrthoDB" id="951358at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38869" checksum="DABCCE1B1B8965EA" modified="2011-10-19" version="1">MKDAPPPPARRQRLPFVTAFLGDILPFLSPRELLICSSVSRTWREETRALPLWRMLLINNPNTAQHAYKGLSLAEMQKIALGGGDVSRLDENASGGERRRKNRVASEKSYTVKPPGMFPVEREVCPRNNLSLCREDSAGESRRKIALPSDRNMLSFTKNSVDSLFKVFGTLQSYMVQLRGKVLSSNNVVSRLSNRLPSGKAIWLHHESIRLWRKIKFFEEVVTLSLSLYKRGERSLKGLRSFVQVEIVTSGEIGSPNHLQWCCFKRALPLDDAYYDYLDLLYLHGPSKHQPPVATASEIDEVVGRIQMYGAIQAVVDEVIMMGNSDSTPLSWDILLSKIENMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN2</accession>
    <name>F9WAN2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_49370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001458">
        <property type="protein sequence ID" value="CCD14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49370"/>
    <dbReference type="OMA" id="CITRSEW"/>
    <dbReference type="OrthoDB" id="1418097at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="PTHR12281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="26884" checksum="1B5E44B76CFFBCA0" modified="2011-10-19" version="1">MASNEATATTFMGESTRPQRNQSRIGLTSKLMQPTSQVSGKTEMERIFEFLSTTDSADGPDNIGQKGIQLLCEELGIRRDSMEMYTLIWKLGVTKSGCIPRYDWLGMVYNYNIESVYDLKLKLREWVKESTGPALTECCCELYDFIRGDNARLMLPETAARAWKTFFGCDPRVEEWIKWYTTVYREEVTRDIWNHVPVFFSNQENATPYRKEDKWPSAFDLFVEWRDTIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB55</accession>
    <name>F9WB55_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2063</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001534">
        <property type="protein sequence ID" value="CCD14486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50950"/>
    <dbReference type="OrthoDB" id="1695192at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="23859" checksum="B436DB6AD7A9E754" modified="2011-10-19" version="1">MIFMVKASSVCLIVVGSFMVLYPVPCACSYYPKALLTDAGVAICSLSRKLKDVAPWTAGKLTELKKTRDEYASKLLNWNLHFHGFPDCGGNESLFEEVRTALGTVNKELGTLPRKSIRAGALAAKSAGRLDEFMTVFAGAHGGGQTFLEKARYCFGYKGSPATRTDFHDCFPTGSRFEIGEANLAKIPESAADRDEPNFASVIENITQCSRRTRTDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB96</accession>
    <name>F9WB96_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001549">
        <property type="protein sequence ID" value="CCD14527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1606781at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="13984" checksum="A7957347B61D0305" modified="2011-10-19" version="1">MTGLRKEAREAGVYVRVVRNTLLKRAVADTEYSVLNDVFTGPTLIAFSKDHPGAAARLFKEFAKSQDKFEIKAAAFEGKFLAANQIDVLATLPTRDEAISQLMSVIQGATSKLARTLAAVREQKEAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBF7</accession>
    <name>F9WBF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001574">
        <property type="protein sequence ID" value="CCD14589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16252" checksum="0A745CD4B0BF0923" modified="2011-10-19" version="1">MSSGMCSAVAKGSTIDAKTDSASIVNNPNRYSSIDCTCSSFCRKRKFRIYFINISFPVFLSWDKNDLFSKYSSVRRHSCLQSATAIPMSVEAAKRKRVRLSIPVKAMISWPTMSTMEMMPSITHEFLSDVQSDSLILLVFSQPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBK0</accession>
    <name>F9WBK0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001590">
        <property type="protein sequence ID" value="CCD14633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17432" checksum="C4A14CC7C8D9501A" modified="2011-10-19" version="1">MWCRHNFTVLYYRPPPPLTAALPYVFFPFGSSNVLDPPVTSSCERPRGVNAMKMCAFSCGLEGFFLSFFLYLILSIFFSFSFLYFPIKKKCLCLIARFLFETIETREAEEKKVKGWCCRCGFTGKEGKMGGFFHYFFPPFLFYFYFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ4</accession>
    <name>F9WBQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001613">
        <property type="protein sequence ID" value="CCD14688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52820"/>
    <dbReference type="OrthoDB" id="1733626at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17271" checksum="39A767C25996972E" modified="2011-10-19" version="1">MAPLTCGMSGVMAGVSHLVARPQAVAFFSGGSRALREGTESERHGHTSGIMKALMGLRCLLEAYSPLSLRAAADVAASLLDLKALFPHVELPWEALRLFCCRATNSDEWRELSPVLVSGVSRVSGHLSVRCVARAARALFELTNKVLQQQWQDSHGTARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU3</accession>
    <name>F9WBU3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394843" evidence="1">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="16254" checksum="D17EA10B86B97E43" modified="2011-10-19" version="1">MALALTRCWSLTVCIMRSWLYNCLPSWSCSSDMPRRRSFPTPPCKPVPVMPVGGTHANMPRSIVWGDTPFNIFHLTPECTNFLFAPGFPECEHRPYTLNVALESLSKRIHPHVSHYPCPAFHDAFHPLLCEHTHIEQSIALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBV6</accession>
    <name>F9WBV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001632">
        <property type="protein sequence ID" value="CCD14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05580"/>
    <dbReference type="OrthoDB" id="1336481at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045399">
        <property type="entry name" value="Tc-38"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20054">
        <property type="entry name" value="Tc-38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc-38" evidence="1">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="258" mass="28923" checksum="38AA456BB4D6F7AA" modified="2011-10-19" version="1">MRCTKQQSSIFFFLLRSIWKCSVPYISSVPQQSWEGLSARTMRRRGHCSLLDIFVAFRSVGISEGKGVSPFAFSRSHPTAFPSTVGTVQGELNVPTAHVATEIPSCDVVTRSCGGGGMREPVGTLPPYYRPMSLRGVLYEGDLMRQLMEVAAMRHFRSPVWATSAAFTRAGYAVLDGEVGVDVRTCMQNVWLFNIQQTNAPESTPCTTASRLRGMPYNARGRPHSLHVRLVLEGHPSYRRFTSPYWWAETMPWRLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC13</accession>
    <name>F9WC13_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001653">
        <property type="protein sequence ID" value="CCD14800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15993" checksum="43E83FC5FF042ABC" modified="2011-10-19" version="1">MQRGTVFVPKTKQKTKCVCPQYSPFSPFSCSRLPSRCILCYFFVLLLLLFLLRPLFFIYFLFRFEKFNMCFPSFPPHPFGFFRETTISPRTAILYYTKTRCGGKKNLKTKEKKCTGRVGGRLLLHPHSVCWSEHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP5</accession>
    <name>F9WCP5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001749">
        <property type="protein sequence ID" value="CCD15040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56060"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22984" checksum="E05EAC1896DD1C52" modified="2011-10-19" version="1">MKVIAPSKSVRVLPARGKARWDEFQLISDKPTSQRMKRSVKGVDKLNEAVKKGVRQTAKKAIHKGNGVVTPFWTPELTKPDVMVQQCRNERKRDARIRWRRKVLADTATRRWEDNMSRPTVTDPISRNLVKSIYAPRPLTSPVLVVDRHPRTKCQQHRHWHWQGCAGGSQRRHRKRQICKSRAPGMGHLSQSGRHNWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCZ2</accession>
    <name>F9WCZ2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C51 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001794">
        <property type="protein sequence ID" value="CCD15140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="691939at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C51" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="17009" checksum="33B2002D65B430E9" modified="2011-10-19" version="1">MTWQCIEFVRRYWMMQEIPVVLPSVRAAGDFWSETNAHFANGTAVVMEKYKNSLSLKDGGSAPRVHDLLIYPKQLGNLVFGHVAVIVRVSGSYVYVAEQNWNNRPWPPPFHNFSRRIPLRYDGKSDAYRIEEANGVSIRGWIRLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD08</accession>
    <name>F9WD08_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_05810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001799">
        <property type="protein sequence ID" value="CCD15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05810"/>
    <dbReference type="OrthoDB" id="1669140at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="135"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="381" mass="42291" checksum="74B08E78671E9A94" modified="2011-10-19" version="1">MSWCFLLKDCFSVLIEKLKKEKMTRTKIWMMVMMFFGVASSAEEKNHNGAQHKALCDLLKIAVHKWNELKSRGSDGPLKKALVRTIFGDDSGEDLVALKREALPTIYVDVEKKKLSRLIWCGDPFEEGGLLEVGQSRWPGFSAPHDLLCLCTVGTGGYPFNNAGSATALCGKPKTTLRADEKKGWSSAGGEAGDQMKATWTNIVGECLQEGGKASDLKKALGDFLGQLEKRSLHDIPDRYQLGEGESDRYPCGGGGTVCVMYYNGTSVKQKKHAIPWWTELEEAINNQAEAEQAYTEQEQKKTEEKPKGEGQNQHHQQKHEETQPQQAHRTAALRSAPQHSQETEQKNTENISTPIATLEETSGTSIIPPCTWFLGAFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDH1</accession>
    <name>F9WDH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2362</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001867">
        <property type="protein sequence ID" value="CCD15324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58540"/>
    <dbReference type="OrthoDB" id="1220124at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="602"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="660" mass="71268" checksum="66931CFD2FAF52E0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDH7</accession>
    <name>F9WDH7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001870">
        <property type="protein sequence ID" value="CCD15330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58600"/>
    <dbReference type="OrthoDB" id="1434985at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="20377" checksum="1E6023402D183F12" modified="2011-10-19" version="1">MVTHRMCPFNVFSYYGTRFFFILMLNWFITFFHFSQPLNFRNMDVVEKFLSLRREGRGEEAYRMLAPGAAMGCPWGGMHYGENVRNFLKDEARFTRKGYLDPVSIEKIDENTFQRKFRWDRGMYEYGNSGFKGLGILPMWREIYFVDEKGIRLVTANKQLKNRSLLGFFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDS3</accession>
    <name>F9WDS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2396</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001904">
        <property type="protein sequence ID" value="CCD15427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59490"/>
    <dbReference type="OMA" id="HAEPEHK"/>
    <dbReference type="OrthoDB" id="1654934at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1231"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1473"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1720" mass="181506" checksum="5A3DC7AA843AE1C4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDX9</accession>
    <name>F9WDX9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 2418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_60020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001928">
        <property type="protein sequence ID" value="CCD15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60020"/>
    <dbReference type="OMA" id="FICSKHL"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="7">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48526" checksum="68CC00EA9D29ABA7" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVTVSTGKAPEAVDWRKKGAVTPVKDQGQCGSCWAFSAIGNIEGQWKVAGHELTSLSEQTLVSCDPTEYACEGGFMDNAFRWIISSNKGKVFTEQSYPYSSGGRNVPACNMSGKVVGANISDYVDLPQDENAIAEWLAKNGPVSVIVDATSFQSYTGGVLTSCLSKILNHAVLLVGYDDTSKPPYWIIKNSWSEKWGEKGYIRIEKGTNQCLVQEYASSALVNGPPPPPPPPIFTQEFCQTPKCLGECTKAAFRTGKCIQMSRAGSVIASCGSNNLTQIVYPLSSSCSGYSVPLTVPLDKCLPIAIGSVAYECSGKAPTESARLVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE01</accession>
    <name>F9WE01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_60120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001935">
        <property type="protein sequence ID" value="CCD15506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60120"/>
    <dbReference type="OMA" id="IHINART"/>
    <dbReference type="OrthoDB" id="792361at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="164"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="549" mass="58050" checksum="0F7E47B6DE2ED1A6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE47</accession>
    <name>F9WE47_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_60450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001952">
        <property type="protein sequence ID" value="CCD15553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60450"/>
    <dbReference type="OMA" id="FLQRMTC"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="383" mass="44769" checksum="E8727049DEC21961" modified="2011-10-19" version="1">MIRRRKPSLSCRRFCFVLLIITLVLYIGGFFERPVTINGRDCTDNVADTLAHYNATTHQDTPLQFITPEIIGTWKQRKYLVALGVLSPDISVRRRRRFLQRMTCWTFPDVATKANNFTGDLIPLYILARHPIHRYKYTDLLKEEARNWRDVVTLPIDEGRISTNKKMGDGTFWGAATEVGMSRKTFMWLDLALTLFDNVTFIAKGDDDMYLRVPQQLANIRALPTRNLYYGYNMPGRYPFQFRYSDGSIFTLSRDLVQRIVAYPPLRRLATQTYDPGYLKHYMLLFMDHEDMMVGHTVFRVARNVTYATVRRCHFHNVYGRTDLSPLTLNSIMLHNIKERHYVELMKHFREIPPATTKFIETSDGIFFECELHSGSPLHLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE61</accession>
    <name>F9WE61_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001956">
        <property type="protein sequence ID" value="CCD15567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60530"/>
    <dbReference type="OrthoDB" id="808596at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="35598" checksum="B096F6090996B12F" modified="2011-10-19" version="1" fragment="single">MNVALPSAAIRLCSLRHPAATRAVGPPLSVAFRSVATYPSPGGGRTGKKANRKKFNFLNGDRLVATEKGPRSRMEVRIRDDIFYHRRVQYRESISENVEKHIRYLPENVKQYVFFRAKKCATANTGFLGVRKAPGVVMHRILQMVEGELLRPENRDHLVELIESVGVTPPSDEEWARYTDSKTGEININLYHHHKLEELIRRFFFGAGRAPLYRKFQAFVVLNRNNFDACPPMRMWSLNQGPIRDEELLERSEVKVVCDIAMELAQFQRLPLDKAFGKLSDEEKEKLSCYASDNADKLLREYEQERLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE82</accession>
    <name>F9WE82_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001959">
        <property type="protein sequence ID" value="CCD15588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60740"/>
    <dbReference type="OrthoDB" id="1715575at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20142" checksum="7CDE9200BD6B16BC" modified="2011-10-19" version="1">MKYLLEKVEGSGVTEIWNSTKRRYQEVLMNKKHVDRSVEEIRLLLEENKTNKRYERGKAENLINTAIQAQQYNDREYEEANQTMSQLEDQQKTARMAAKEALEKLYDSEKSGGLYWPAACDAQTSKVIFTGTALQAALVTWRARTKWEESPPENCPVHAEWEKSVEKAASHMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE91</accession>
    <name>F9WE91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_60830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60830"/>
    <dbReference type="OMA" id="ETIEFHT"/>
    <dbReference type="OrthoDB" id="1727325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389027" evidence="2">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="26512" checksum="88A2D64BD354E2ED" modified="2011-10-19" version="1">MTTTMSRVLHLMTVTLLCARVGMGQASDDDDCGGQSIPQKVEEVQTMCDVARQLRALETASQSAVGAVVSSARDASEAKERAEKAVERAKSKKRGVDAATEAAARAAAAAQRAETVVSDARKHAADLTAASKDAIETTDESLRLLATCEKADEPIRTAAKKCTGAAAEVTSKSLESAFDALAELLPDGADDIREHGAVFVKGLKSLEDDVRTAGEAKSEAEKAEGDANDAADGARAVLTGVCVLLLLAALHFSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEC9</accession>
    <name>F9WEC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 249</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001992">
        <property type="protein sequence ID" value="CCD15636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06550"/>
    <dbReference type="OrthoDB" id="1679551at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="285" mass="32277" checksum="9FF386DF2B489C70" modified="2011-10-19" version="1" fragment="single">MVLSFMPVGEPYGGQSSPIYTDTFHSGDSSVVLTYIGNNSRAIRTTEGHRRGADRAVDVNARYIDIERAPPKAAGSGMGNQKSHHAAAERRGVSNHLVESPDLSRPEEPLHSSGDEWNETYSEQLREYEKERGETPRINIIGGHNDDCEMSETLHDTVLSDIKATWHRDMPTPTVQIRAEDRYMSSEPTYVSHNVTRRCPQSKEPQPQPQPAHRQRCKEPTDECLTHTPDAQREPSNPPDDPSAKPSAEDHKNTGPYINTTHYKYTAHYKNTTHYRRWCRAPRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK0</accession>
    <name>F9WEK0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002026">
        <property type="protein sequence ID" value="CCD15710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16142" checksum="C0D6D80D3E1FC3BC" modified="2011-10-19" version="1">MYLVCPVAASWPRTQKGLPFVEATGGVEVRAGACGQAAAPRMNFRLPCHVHSEMFFSNKACGCCAWLTCTFQTSSNKACDSLLWLKRELFLCINIYHSLRHGILILFPSGSCTAFATLVIFVFRYPSLAKACLITFRWISVVYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEP2</accession>
    <name>F9WEP2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 296</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002044">
        <property type="protein sequence ID" value="CCD15753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07640"/>
    <dbReference type="OrthoDB" id="1735937at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18875" checksum="B26C0012D051543C" modified="2011-10-19" version="1">MRTPWGWVWLLPKGLSSLGESYALLRLGKGFCMASARGLGMVLGLWLWLWFGFLCPQWVNVMSPGRLAPLQPAHPTGTSRTTIKKTDGCRASELLSRHPGLLPRSSRRGLWRRFRFLYHGGMSFSCDRRCSESVFLGFPLRTSSRASDLDDAKPSDVFPTILWSAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEP6</accession>
    <name>F9WEP6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 299</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002047">
        <property type="protein sequence ID" value="CCD15758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07690"/>
    <dbReference type="OMA" id="DQWASAT"/>
    <dbReference type="OrthoDB" id="1657296at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="626" mass="71265" checksum="70F501FC87B8A4D7" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WET2</accession>
    <name>F9WET2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002060">
        <property type="protein sequence ID" value="CCD15798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16287" checksum="4F544390A9DC366A" modified="2011-10-19" version="1">MDELNELKQIKTTANAAMPLLLSSFFFTPSLTHSSSPRVSFEECVCVARCALGSVVSRSFISSCFSVSFSFACTLLRESKQTHTFDRFSSFLTVIIMIIKAKNLCALFSIFSNICFSVLLIFSFTPFRSATHFITLYTHSFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WET9</accession>
    <name>F9WET9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002062">
        <property type="protein sequence ID" value="CCD15805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00870"/>
    <dbReference type="OMA" id="YQHERIE"/>
    <dbReference type="OrthoDB" id="30750at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PTHR12280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="479"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1348"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1469" mass="162656" checksum="A3D4FE1162087B10" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEV2</accession>
    <name>F9WEV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08190"/>
    <dbReference type="OMA" id="NCIRDEV"/>
    <dbReference type="OrthoDB" id="1363856at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="509" mass="54519" checksum="721E9D52A8F037EB" modified="2011-10-19" version="1">MQLSSYMTNIVSEVKFLGRAYVDSLMAPEDDHHDGENCEKTADGSNGSVTPAATVVGALGTSLANLIPGASSFIPSSRGAGASDTNLNDECSSVNPEAVNFREVGGGCSAAVVGPAHSSCTRYAKALGGGITTPSAPAPVEEPRVTPASTTIAQKMSTRKSASTRSKFGAVKMVMDPAEVQCLERLAVPSGLAATSPALGHPCGFKGDVVEPVPELVSEAQNWNCIRDEVVQLLKSYVERQVARSAWASGVLRRFADNAIQCLPRGANHDSLSNESTKKTVPLNTSLSGGVWWGTESSLRTCLRNALPAEVWRLDLMDAAPNPSAGVGSPLSRREDASLPETFQTSLKSFQHWCQGRQLYTLLVSEDRTHHHSPPMLPLLAPAMEQCMMDMFISCLSPLIRGVAKSTRESLQSRGVQQKQPHRSGDLPDINSLCEWGKQLMDLFCAPLNEAENVWKRRVQGTSGDNAEHAHTVLAMVTAVQTGTAALWLMREAAIMTLLLVWSLLNEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEW9</accession>
    <name>F9WEW9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 322</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002072">
        <property type="protein sequence ID" value="CCD15835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08360"/>
    <dbReference type="OMA" id="PVHRANE"/>
    <dbReference type="OrthoDB" id="1581143at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390266" evidence="2">
        <location>
            <begin position="24"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="16822" checksum="38422F53C1993600" modified="2011-10-19" version="1">MGCCSLIRYLGLIFLLAVFVASGFSCVSNPSASAMMLAKSNLPQLLRMAGVKYRLNAAEYTMIVQGLGASFIGFSLLILLGVGRSFFAFLLALIVALLTVVFRIDLKNPAKMSEADAFNVLRDAAIFGGLLIVAGGMCRSRPVHRANEATREKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF20</accession>
    <name>F9WF20_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002090">
        <property type="protein sequence ID" value="CCD15886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08800"/>
    <dbReference type="OMA" id="IDMMIAR"/>
    <dbReference type="OrthoDB" id="1619855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29820" checksum="5E9FB78D13A1225F" modified="2011-10-19" version="1">MCLNAHPDCSFSFSLRLRCRTLCYLSKRKERQIHQVHTQRGSDPGKLMKGLEDWLASSSSSSSPNPKVSSTKTSAVNEKDVDRKITQSNVRERKDELRNRMRTLLGESAVTSVVTEESMRTIGDSVPPAPSLVRCSSDGGDLASTGSKVIMRADGDLGGASPQQKPKEIQYRSVEVMVVDRGTQTTTTVGCQTETDIPSMFMESGSPFRGACCHCCSCCHTDGRRGLLPRRPQYDENLPSRFNQELETIQKSIDMLIARYNLPPPPLAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF41</accession>
    <name>F9WF41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_09010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002102">
        <property type="protein sequence ID" value="CCD15909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09010"/>
    <dbReference type="OrthoDB" id="1671725at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390246" evidence="5">
        <location>
            <begin position="22"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="89"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36866" checksum="B4E2B92CCA878759" modified="2011-10-19" version="1" fragment="single">MACFMNVVAVVILILLGFVRGQVEVAKDDNIEPFSFLCRIYNVAKNPPINFVDLQEADKIVEDIDALNRFLSEEKRHDEEEGVGNNSETQVKPTVTREAALAQLSLNQITQKAHKVLDEIEKMMSPKKIEKAKAEFNKVIFGDGGNEDNMCQATVNDMDNRSKACGPPGLTSKGESAGKNLVVDFFCLCAQRTDIKEGVDKLCGFYVGRIDSYYDWGEQGPWGSSTMWASIKGGCGKHMQQHPKSTGEARYILDQFLKHLKTGRVYRWGDNTQVEGSERKRGMLGTGVGTKSEKHGNGKDTVLHGKKWERRQTPAGSVLLRPETKWEKPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG8</accession>
    <name>F9WFG8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002142">
        <property type="protein sequence ID" value="CCD16038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10060"/>
    <dbReference type="OrthoDB" id="1711841at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20836" checksum="8A9D799EB6F4B0DF" modified="2011-10-19" version="1">MATNTLNSPRAIPWSMERDVAEVLLEGVTSPDTINLYLLLRPVLAGITVDLVCFTLGDFVRNPRHCIPETDVCDSLWQYLPYLLWKFRMSATPLVKHFGPTETWTKWQWDSWKIYIDMDETPLEAIDEEIWHRCRRPPVVQYQPYQGVVLVGAAAPFIQIPYSTVGYLVPIPMSPGDWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX1</accession>
    <name>F9WFX1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 431</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_11500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002193">
        <property type="protein sequence ID" value="CCD16201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11500"/>
    <dbReference type="OMA" id="WRLWDLC"/>
    <dbReference type="OrthoDB" id="1210229at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="684"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="828" mass="88531" checksum="F596C3FDE886E1C3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG06</accession>
    <name>F9WG06_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_11840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002211">
        <property type="protein sequence ID" value="CCD16236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11840"/>
    <dbReference type="OMA" id="INAGYMQ"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="7">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48206" checksum="E57FDD062986C1B6" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRMFKQSMERAKEEAAANPYATFGVTQFSDMSPEEFRATYLNGAKYYAAALERPRKVVNVSTGKAPPAVDWRKKGAVTPVKDQGSCGSCWAFAATGNIEGQWKIAGHELTSLSEQMLVSCDTTEDNCRGGFADRAFKWIVSSNKGNVFTEESYPYASTDGYVPPCNKSGKVVGAKISGHINLPKDENAIAEWLARNGPVAIAVDASTFLDYKGGVLTSCSSEGLSHDVLLVGYNDTSKPPYWIIKNSWDKEWGEEGYIRIEKGTNLCLMKEYARSVVVGGPPPPPPASTFTQEFCEGAECQSGCTKATFPTGKCVQLSGAGSVIASCGSNNLTQIVYPLSSSCSGYSVPLTVPLDKCLPIVIGSVMYECSGKAPTESARLVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGC5</accession>
    <name>F9WGC5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 488</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002257">
        <property type="protein sequence ID" value="CCD16359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12970"/>
    <dbReference type="OMA" id="NDGAHSN"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394754" evidence="1">
        <location>
            <begin position="25"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="734" mass="79861" checksum="85E6CED22B97BF3E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGC6</accession>
    <name>F9WGC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002258">
        <property type="protein sequence ID" value="CCD16360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15353" checksum="43639F85276E6BB5" modified="2011-10-19" version="1">MNVAQVPHAFSTAHSNSITVGGSRTVKGFVEMHRKAVNMTLIPPSDTHPRPLQFAGLTKEIRKRQVQFEQQLLSLQEREQQQRQEYNKSTQRGINLTHHLLSGIDNDPSSSEANKMILRGQKKKDVKQQKVLKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGI7</accession>
    <name>F9WGI7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 506</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002277">
        <property type="protein sequence ID" value="CCD16423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13440"/>
    <dbReference type="OrthoDB" id="711727at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="33482" checksum="51DF8516AA214B0C" modified="2011-10-19" version="1">MAAKRFVRAWRENSVRFPESNLLLVSHGDAISAVVDAVKPGYIVYETEYLSFVVLRRKGEQESALNSNRVFDLVTANGVQWLATQPEVSGDASVVSDHHDVSPQLPSDRIMDNPSGDLDNVPASSVNVRSLNTTTFIGVRVLVVASQIPAIEFWAVKANALTYVFAVTLLELIFVAINIFAELRPTILGTLARIEYFPAPRSNDYLALGEPNNRRRNPLSMVILLTAAALRSCITVIFAMLVFFVEDILSQTEFRLCAFIHEIFSWPLGIFLLGMLFWLNIVRMSFCVPRLLKREFGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGZ1</accession>
    <name>F9WGZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 576</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002355">
        <property type="protein sequence ID" value="CCD16580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14900"/>
    <dbReference type="OrthoDB" id="313703at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="PTHR23069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="647" mass="72571" checksum="9D4D3FE75C6D9054" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH99</accession>
    <name>F9WH99_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002400">
        <property type="protein sequence ID" value="CCD16688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395050" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="16522" checksum="571E231BC526B6F8" modified="2011-10-19" version="1">MPFFFAYPLFSLFSNCALCYLKAGQHGVCWWLWVAATKVITHLHQRGSLISCYTRDERRGGRRRRKHKDRKFVCPPISFVRRNNIGDQAGARVRERRSDPLRIGERKIHFWHVLISTLLRVKEEGENTVIRSNNRGGRGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA5</accession>
    <name>F9WHA5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 620</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002404">
        <property type="protein sequence ID" value="CCD16695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16010"/>
    <dbReference type="OMA" id="HIATSEV"/>
    <dbReference type="OrthoDB" id="1708258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="202" mass="21931" checksum="386422CF71453950" modified="2011-10-19" version="1">MLIIIIITVIPLPLLRKLHPYNHSTKHVQHIATSEVVSTGCDSVYHSYSSFLLLGLCLCRAVCLGRAMVRCRSTRSRSVLAHLHVVAAMPPCDRKRSRHSTELDLRALCYEIGQKMHFLGGLAVGVTGEGLDVVGSRREEHGDCRVYNVVLQMAHASDLTIAALRSACASTLQGKLLDAGPGEGRLATIPVAVRVLTLNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHF1</accession>
    <name>F9WHF1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_16470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002422">
        <property type="protein sequence ID" value="CCD16744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="16080" checksum="174867C9A78F2161" modified="2011-10-19" version="1" fragment="single">MAFLLFSFCFLPSFAYLFLFCFYFYSLRLHRATLCDERYVYIYICIYLRLCVCICVYFFSCEQCSLLLLYHISPFKSRWRYMHTCTHTFIYIYIKKTTTTAKSIKHSRSNNNNGEKKQQKKRKRTILHAKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHM6</accession>
    <name>F9WHM6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 673</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002462">
        <property type="protein sequence ID" value="CCD16819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17180"/>
    <dbReference type="OrthoDB" id="190523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="505" mass="55945" checksum="0979578EF69A4CB7" modified="2011-10-19" version="1" fragment="single">MLKPALERVLVRCCRPIFSNTEDVREAMAALLDLSAYANRAVTKLIAKPLRRFCHKDPDTIATLLETVPIDAAEFSHGRRAAMLLRCIPNQSCDEVIWERVVRITLMGLQGHKWSLHDCSVAIAHAGRGGRHAPALAAAAEELVAAKVRTASQSELPVLLVILTSLPDLSRSPCIQGAADRIVQLAEILSPAAIGQICACVNKISLRHTAMAIALQEEAIRFAEESDLFSAVQLFSFVCQQEKDAISPDAVKCLVERVIEGRDLDQTTVMALCRALRAIPRTLRPELLREITEMMEFLGVEAKGLLLLPVVEGGLKGDVPVEDVQLFISRFLALDCLLPEEHTRPDAYIAAVESCVECITERLEDIVSDENPPFSIIPHLLDINMEAARQCGLAIIREAAEQGIHFPTLQAFRFLLALGDHNMKDKRVYRHLRNEFAKTAAGIPMIQLCAALKCFVRGLVEEGETQSLDEQVEQELEREDMDAFLRFCVENLLRGFADGMEVKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHV7</accession>
    <name>F9WHV7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 697</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002489">
        <property type="protein sequence ID" value="CCD16902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17850"/>
    <dbReference type="OMA" id="CFREDSI"/>
    <dbReference type="OrthoDB" id="1140237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="255" mass="27832" checksum="2581B6670A4FB585" modified="2011-10-19" version="1">MPFHKRSSGPMAKRVVPIKRYITECRKPARPFLNVCRGHVYAPEMVKFDTYVVVPICSLTNRDLIHDLLLRRCLYHPLPASVAEGAPLDVAVRPPRRGESSSERDGALPRVLVHVSSLKVHTGSARQQAPDGNVRILVTVEGSVASVKYGLLPGTATTIRFVDTFDVQVACAPPELATEAGTPLSGELSHVTLTARRGDNRLACSGQGVVISLEPGAIRFFPPYQPRRSPLLFKLRAIGDEVEVVMENPASENPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI96</accession>
    <name>F9WI96_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 752</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002550">
        <property type="protein sequence ID" value="CCD17041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19000"/>
    <dbReference type="OrthoDB" id="580952at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="26893" checksum="B7135FB7D08BE24B" modified="2011-10-19" version="1">MFQKQETTREATPVVDLLNLQEVDVGKTVVFEAKRGSCSREIPALIKQRFPFACWIRLLGVGKDFLCAFSNSQPSRSIRYRIEAQVIRWSGWLVLFALGSTILAKTLTESYNPAYEAHLSALRRAKRDKVLKAKQTPRLTVNDSVAGAFPLHVDDDCDSEEYLETLRYEDDIRSRRRGSTVIDALPRGQRRPVHVRPTRYELQQQYAICWEIYNRRAPPERPQRPKVLPMRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF1</accession>
    <name>F9WIF1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 780</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_19500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002581">
        <property type="protein sequence ID" value="CCD17098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19500"/>
    <dbReference type="OMA" id="HSCAVQN"/>
    <dbReference type="OrthoDB" id="659103at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="4">
        <location>
            <begin position="255"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="477"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="524" mass="57921" checksum="5630E14E97A0EC21" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS3</accession>
    <name>F9WIS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002630">
        <property type="protein sequence ID" value="CCD17221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20580"/>
    <dbReference type="OMA" id="VERAMTW"/>
    <dbReference type="OrthoDB" id="1338662at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="247" mass="27121" checksum="5CE88659CAD32D61" modified="2011-10-19" version="1">MGDKDDTSNGQNSEKVIEGRRRLTWEEYRAIYVEEQRRRFLAQRGGANISGGAVRGGVTPGVYSSAPPQSQQPPHIAQAHQPEREQRFYGAAGNVQSNVRDAFFAVWNFLFSEEMLIRGIQIVGRAVLASVLVFHSFDFYYIMVILGVYTVWCVVKASFSSVWIKRVGTGTVRSPEGVAPADGYGSGGLKGAVPARPQNVTPVRKVLYIVGRCFSSFVLSVSPTYSVERLEAELAADGIVAPHPHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU7</accession>
    <name>F9WIU7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 837</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20790"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19380" checksum="5FD7381A12C9A0D5" modified="2011-10-19" version="1">MEVIAPSKFVRVLPARGKARWDEFRLISDKPISQRMKRSVKGVDALNEAVKKGVRQAAKKAIHKANGVVPPFWTPELTKLDVMVRQCRNERKRDARIRWGGKVPVDTAIRLWEDNVSRPTVTDPISWNLVKSIYAPRPLPSPVLVVDRHPRTKCQQHRHWHWQGCTGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW6</accession>
    <name>F9WIW6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002648">
        <property type="protein sequence ID" value="CCD17265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20980"/>
    <dbReference type="OrthoDB" id="1745569at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394805" evidence="1">
        <location>
            <begin position="21"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12696" checksum="221F42F43659DEE0" modified="2011-10-19" version="1">MVSALIPFIAPAAICRCAFTLGCTFRYNVVGSFIPLTSNVLTGACFIHTDSPSKQTDKYPSGSNKCRPHGSHISVPFTRAHPFRYAPHSQLPVKLLLPMDGSAMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ12</accession>
    <name>F9WJ12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002670">
        <property type="protein sequence ID" value="CCD17313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21410"/>
    <dbReference type="OrthoDB" id="1708222at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="21162" checksum="252ECAC5CC19D733" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEVNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDNDDMPLEAIDEEIWSRCRRPPPPYQPYQEVVLVEATPAFIQVPYSTVGYLVHLPVSPRPWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ85</accession>
    <name>F9WJ85_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 885</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002697">
        <property type="protein sequence ID" value="CCD17389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22120"/>
    <dbReference type="OrthoDB" id="1678331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="287" mass="33035" checksum="AAF4344305202105" modified="2011-10-19" version="1">MNMEGEREAVTSWTMESEVEQVLIQECKTRDNINLFYFFVEYYGWTEEKFRHLTLGEFLKQPERYIKNANRLEEVQKTMQQMLKRLHDNTIKDVRCLVGNGIITLCDWVLRGASTLLDRVPRGALDGAVREASKQPRPPITSGSISVQRSNEESDKLAHQVAGNPSTQRQPGGTRDNELGEILQKACKSWEDVRLVDFLAQEYGKTYGACGSNVTLAAFLENPSHYIENDAEREEVVEKLPDKLHHLRGCILRDVTFLRAVGITTRRDWVYRQLYHEMLTPITNCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ86</accession>
    <name>F9WJ86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 885</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002697">
        <property type="protein sequence ID" value="CCD17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1656330at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="685" mass="75051" checksum="D61DAA0993603D98" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH0</accession>
    <name>F9WJH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_22930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002726">
        <property type="protein sequence ID" value="CCD17475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22930"/>
    <dbReference type="OrthoDB" id="1672264at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389224" evidence="8">
        <location>
            <begin position="28"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="100"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD17475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43905" checksum="F0638179B8A0C2F9" modified="2011-10-19" version="1">MMMTRMAEYFVLWIMVLLLMSWSATLCASSNYPRTIPTEAGESICSLSRKLKDIVPWTALLLAELRKNRDVFASKILEWQLHFHGSSNCGLNESTLDEIRTTLDNVNEELKTLPRKAIRAGALAARSAGRLDEVVTVFANAKMRKVFSTSYYCLGSGGDPAKRRDLIDCFPVGGKIEMGENNLAKIPERIADPNEPNLTAIITKVTHSAMASYFHQKYSGDDGANCNLINGKSGILGGGLKDKLWWGGGILTIGKSFDGKMEKTKFTAGEIADAFKDREGSKAFWTEKPSEKIPHLQKTLAAFQDFKDTVSRITQKFAKIEKIEKQIELCLSNETMEEGHTQSCFKNAVKLNAELQAANALLARYHKEKGPLPSGSASILHQSVVNVWFFFAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH9</accession>
    <name>F9WJH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_23020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002728">
        <property type="protein sequence ID" value="CCD17484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23020"/>
    <dbReference type="OMA" id="FLMEDWE"/>
    <dbReference type="OrthoDB" id="1318230at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="7">
        <location>
            <begin position="73"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="465"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="521" mass="57634" checksum="C5EBFDCE77560153" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY6</accession>
    <name>F9WJY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_24500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002788">
        <property type="protein sequence ID" value="CCD17646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24500"/>
    <dbReference type="OMA" id="ETEFHEN"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395122" evidence="5">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37928" checksum="C1A671557EFB3E9D" modified="2011-10-19" version="1">MWRNAIIVLVFFHYFVEAVNCHNEPERELLCNIFRQSERVLQEFAKAELIKEAIYGPMKENALIIKGEGVSLIPSCYRPILRNQFCEYLGSERVKDGCFAESLLGTFFCICVPGAQRGTVSNLCGVDIGRHFDLWHGTFPMRDDETEDIFGNVWRNVVGKCTGGSGNVESGSEELEKLRMAVEEVENKTRLGTNGFFYFGGSEEKGCGGSDGRNVCAAYLKKDGSVSKARIPWVEKIKKAITQLQEMKREKRSLDSREKTTGRNSESIVAPPHRTGEGNTELTVQSEGAGTPPNSDRTHSKTKISTKTSPITNIPHLATNLNEDGSLLTNQEWLVIAALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W393</accession>
    <name>F9W393_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000376">
        <property type="protein sequence ID" value="CCD11601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="14444" checksum="B5246BFCDAA8C2B1" modified="2011-10-19" version="1">MNFPFLLWCFSLEYSWSCGVKIYFLRPLQCGSLVWLDGNFDSVMHVPYFLQFGMYGMLWGKRFINCLCILRPTRLHSSVTLNGSAVCRFVCSFQRSFQQSICTIRCLPSFSLSDGDALNRHDAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3A0</accession>
    <name>F9W3A0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1023</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000377">
        <property type="protein sequence ID" value="CCD11608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25790"/>
    <dbReference type="OMA" id="CLAMHEI"/>
    <dbReference type="OrthoDB" id="1654621at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="805" mass="92236" checksum="D1971FED09E4225C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3C0</accession>
    <name>F9W3C0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_25980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000390">
        <property type="protein sequence ID" value="CCD11630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25980"/>
    <dbReference type="OrthoDB" id="1667421at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388619" evidence="8">
        <location>
            <begin position="26"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="43"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD11630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="438" mass="48336" checksum="2E140407DEC12F6A" modified="2011-10-19" version="1">MPQELQFLLILLCAVLLLYPGVTWGQEEGQEEGQEEGTPPQPHAIPKTASVSICTLSKKLKNIAPWTVKKVEEEMERIADFEKKMQGWHKIFFNKPENIGKCALNGYLYKSAKKSLEEMRSKIAELSKQASRASAFAATSAGRLDEFIMVFANAKAKSEDGKTYFCLGNGKGNDAATHDDLAGCFTGKIGEENLAKIPNKPDTEIGEELDEELKVRLDSQESNLENEIKNIAHEKVVKTNPNQIGEGHCNLINGKSGFVNGGAGTSTKEKLWWGGGILTIGKGFDGSIKSEANFVAGDIDTASEDKATWTSKPVEKIVHFQKTIEAFNKFKDTKREVTGTIEKIEKGIDECLGSAQVKIDGETTESDPICFDKAAKLANELQETRALLSRYESEKGKLLPLHPDNKTNKEKTKTTHRIRGAAERNKPIKLFSLLVVMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F5</accession>
    <name>F9W3F5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000403">
        <property type="protein sequence ID" value="CCD11668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02890"/>
    <dbReference type="OrthoDB" id="1709445at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18460" checksum="0D72D5551D54B38E" modified="2011-10-19" version="1">MRDYTGICCLLHSQPLCAVSKHCVTLVFTLHGPRLKNNTITTPIALYSIMTFQEPFRLRCIAGTISHGRLRPVNIYINKCVSSLFFSWLITPRPLALNPDTPMYHNGPVLCLGINTPPALYPFGMDWCGQEARGCQRKYAALPALWGGRRCENAPPHVHALLDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3W6</accession>
    <name>F9W3W6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_27840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000484">
        <property type="protein sequence ID" value="CCD11844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27840"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388635" evidence="4">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="88"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="47795" checksum="8408A0D7DABCEAC4" modified="2011-10-19" version="1">MMLRKFALLPLVVSMGMASSQHPSAAEFNLFCRILGKANDMMYGSNYVYNENVDRAIMREMEELYNITTGNMNDFGKMLWKTKDFLTDHPPPKETKNLQEAHRKIGKLIDEGEKKIEENRKIAVDANKKIDEAKLYVAKGIYGEHVTEVPKEDGNISDILDNTSSIFVNNTSAVHSCGYYEDSPGKTLINDLFCLCVGDPIDAHGPCHPKIWPPKGRSGTNGKWTQIKYGSETLGVIQSFNESFEKIERVCRKEMIKAKIKTERMPALLGEFVAMIGKVATKPDEEGKYIFGHSGRSKHRELVTECDGSVGESDGTEAAEKYNEKICVDYEKNFKNGQYEIAWHNKFREASEKMNEAKELEEKILKNRATLILLKSQAWIAYSREKEDETANLDDMDIAHLLDATKTSSISPFPYLFLSLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W481</accession>
    <name>F9W481_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000526">
        <property type="protein sequence ID" value="CCD11969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00230"/>
    <dbReference type="OrthoDB" id="1714260at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18819" checksum="419D50E911F48738" modified="2011-10-19" version="1">MIFLKNSLLTNLLRVILSTFIALNLFLPYIFFPASFGEFSHNAPQQAVTLSDISGPLSTEREGQPALLFPTRITNMHRHTLMRNPVTSCDYNCLRCGLWSHSQWARPNMPSFGIGTSSRTFCLVESKHGRTQWRLFLTPHLGGGHQPRYTGMFRSNNMHNTNKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4E6</accession>
    <name>F9W4E6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 8">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_29570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 8"/>
    <dbReference type="EMBL" id="CAEQ01000546">
        <property type="protein sequence ID" value="CCD12037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29570"/>
    <dbReference type="OMA" id="VERCKAM"/>
    <dbReference type="OrthoDB" id="446616at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="607" mass="68078" checksum="1A642D9B6D620CDA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4L7</accession>
    <name>F9W4L7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000577">
        <property type="protein sequence ID" value="CCD12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30250"/>
    <dbReference type="OMA" id="FFVLECD"/>
    <dbReference type="OrthoDB" id="280984at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="758" mass="81901" checksum="52B8E6428DFC2411" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4X7</accession>
    <name>F9W4X7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 124</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000627">
        <property type="protein sequence ID" value="CCD12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03240"/>
    <dbReference type="OMA" id="LAHAICT"/>
    <dbReference type="OrthoDB" id="1335683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="284" mass="31969" checksum="44625C5B515199B2" modified="2011-10-19" version="1">MLIDHEHRAIDFSDNTTGKLSVHILKRLRDAIDCNDFYCNLVFDNNVFTDDALGILAAILKGCNPIERLSLRSCNLTDLELVHLAQAICTRKSICHLDLSKNPGITSSSCAEITRIIQNVPSLESLLLIGTGLQEKGCSYILQALERNPSIRVLELPFTVGYRVLDKARLIIEKKANKPEKAGDTLEGSKASHVDDNRMQHSQLLKSSVCLPSLEYLPLTRMSKGFGNKCNNSYVEDLLELPQWADPSIMNAAVYLKVLDKRCEMLDEHIKDRHRRMLARRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W504</accession>
    <name>F9W504_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000640">
        <property type="protein sequence ID" value="CCD12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31510"/>
    <dbReference type="OMA" id="WYILTTT"/>
    <dbReference type="OrthoDB" id="908054at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="582" mass="63581" checksum="DC5DACFB2DA7C2DB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W506</accession>
    <name>F9W506_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endonuclease_NS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_31530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000640">
        <property type="protein sequence ID" value="CCD12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="168421at199999999"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394693" description="Endonuclease_NS domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease_NS" evidence="3">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14048" checksum="14D5BA022392A7F2" modified="2011-10-19" version="1">MSASSVGRVFALVSAALAGGAAAMLLQHGKHSDEGRRHCPDSAMRRSNGDTQSSPAAGPRPHGFDDSNVVSEGGHSGDTFLERLTSKGLPSHDRVRYFMGFVASLNYERRIPNWVLEHLPGIGPEGATYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W523</accession>
    <name>F9W523_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000646">
        <property type="protein sequence ID" value="CCD12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31700"/>
    <dbReference type="OMA" id="RCERTEV"/>
    <dbReference type="OrthoDB" id="1654502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="28678" checksum="8B96412002E97245" modified="2011-10-19" version="1">MEDFAKRELRRDVLVSFEERCVSTLEASGLQAFMIGSVVTEVVRHLKYLPREGETERSRSSVLCRPAARGRVPTMFHRFSSADTPVEMVAECLYKPAEKNFPVVGGFFLVDAVGEGVSFPEGAEAPTQTIVLLQVTRARNQRTSTCKVCRLRERLAASFINWREMESRLSYEIIYVQHANSAAIATRQRCGRSGTVSDLASERFWGGVDQFRVKLEAPIAKLLLQEIYDVKITEDVAAIVRDLRGVNITAVAGADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W597</accession>
    <name>F9W597_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000683">
        <property type="protein sequence ID" value="CCD12346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03330"/>
    <dbReference type="OMA" id="KCEANDN"/>
    <dbReference type="OrthoDB" id="1589189at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="289" mass="32232" checksum="25A4ABFDFAB5E138" modified="2011-10-19" version="1">MGINTGKLSEIDAENVKSIHMGTNRPLISTITDCVCSDTSLSRKNAHPTNGEGIRSSECVATIPPFGVTESNRSSAMVSSESGEKDNVKCEANDNVHLPVSFINLNTNGLNNETMEYEQHRAARTWLLVPFSSQDSDFDGDKDDFIDTLLHVAEDKMYLFGFSYRSGRSELTGSCRPSRRKRCRGSSNTRQTTAKQDGLGSLLVSSSQCASFSFVNWQQYGCKEVNNYGAQCQSLTADDLLSFEERHVLSRYALSNGKLRKECADPYQFFTTRLQELRHSIEESSTRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B2</accession>
    <name>F9W5B2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000689">
        <property type="protein sequence ID" value="CCD12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="112" mass="13705" checksum="3C757224E5DBA424" modified="2011-10-19" version="1">MKIRDKQIPHNHFWNRKNFRRKSQKKIFFYKIFFENLQKFEKVFDTIFCKILKNHYARQIGPKTTNTCQIRVFRIFAFLTFLTIFKKTGFWPFGPKKVNFGKIAKCPFSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E7</accession>
    <name>F9W5E7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000707">
        <property type="protein sequence ID" value="CCD12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32790"/>
    <dbReference type="OMA" id="NRENSEA"/>
    <dbReference type="OrthoDB" id="1506215at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37432" checksum="FA8850BD63E1D49A" modified="2011-10-19" version="1">MEEAITTSGAHDGSVVDTRLTMQTIADQQGIIKTLGEIITTLKTRIANLEGALAAKEGQSKNAAGEPAPLQESDAEAKRMLMEKVESLTSEVQSLRVERDELNQKCCQLVEAVEHYKMELQEAHARCVKLQWADRNYRAARSAFCLADARHRETEQRFRHLEKKVDISLPERSRWKALAMSLANQLDGPSRRRAMQRIIVISNRENSEAVTEPGAMQIGDISAVDGCCKNMGSSDMLNIPELEAFEMFDVFDGMKRTSTSPQTRLSPRCTTVNQIASLSFDQLPKRRERGNVKIAAWQKSVECKSVNDGPPDMLIPLMGNSRAVSGKSKKRFLAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J3</accession>
    <name>F9W5J3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000719">
        <property type="protein sequence ID" value="CCD12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33240"/>
    <dbReference type="OrthoDB" id="1732821at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="16935" checksum="629288EB22DA9475" modified="2011-10-19" version="1">MLCPSTSDKKKFVGDPLPRRAQPFLQPTVAKVEAVAPWEDVSSWSGGSTSSCTSSASLRVVSRTGSTSEHAVNAESIAARMDCIRRNNTNHSRGGACRALRETTSLPASDTSHATSFLWREGSGDHANAARPALQVDCMDNTEMSQLLELTNGEDILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5M0</accession>
    <name>F9W5M0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1341</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_33490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000731">
        <property type="protein sequence ID" value="CCD12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33490"/>
    <dbReference type="OrthoDB" id="1672178at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="94"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="38841" checksum="B637C210E66DF8B9" modified="2011-10-19" version="1" fragment="single">MTLVLFLLFCQGLERKMMKLFMVMMLVMGGWVRHWRVMANAAVSVNEGDNKEPFELLCKIYNVAQHPPIKPVDTKEYQKIVDDIDALSAAANGKEGVKTQSEETKSAQTQLVGITRDAHKLLDEIKRINPEREAEMARNALNQVIFGEHGKEGDLSPGTLNGVRGRMAACGSRPLDKKGESAGKNLVVDFFCLCAKHDEAEGVDNVCGVSVGNGKDSGWDGVKLVSQDTLWDEVKNGCGTFAKQGVTSTQDGYSLHREFMAKVKAGGKVKVTNTETVPKHGMLGTAVSDTGNSNFHCNGKKAVSTTRVNVGSGVCVFYGTHHQEQNIEWLKKFKEGLQLIDKLNTETASWQHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5P1</accession>
    <name>F9W5P1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000744">
        <property type="protein sequence ID" value="CCD12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33690"/>
    <dbReference type="OMA" id="YDSVWPR"/>
    <dbReference type="OrthoDB" id="1499064at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="838" mass="90198" checksum="0D71899B240E59F8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Q4</accession>
    <name>F9W5Q4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_03450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000750">
        <property type="protein sequence ID" value="CCD12507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03450"/>
    <dbReference type="OMA" id="CLMAVGA"/>
    <dbReference type="OrthoDB" id="581771at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="27"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="393"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="545" mass="60122" checksum="009B0C14D9F24991" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Q8</accession>
    <name>F9W5Q8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_33830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000751">
        <property type="protein sequence ID" value="CCD12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33830"/>
    <dbReference type="OrthoDB" id="418348at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="231"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="493" mass="54084" checksum="B80838B5433AE0BD" modified="2011-10-19" version="1" fragment="single">MMECEPSSDRRISPIVAKLEPLVTGYDCSVPQQCPSASSPLLERRAVSAGVEPSQPSLRRRCSDEHDVPSIMNLNRQLEDLSRDIKVLNGHCSEESIPRLSRTPLKPQPLQHEKQPQKSRLPLLNKPESARSASTPIRAGRQAPCNRCKTLPTVSCSPPRLRASSSFRRSDGNKSSSPTSIRRVNRQPTPHRISAAGSAACVEVTTPAAGCADDAQAEGKQGAAARTRGGRIRVVVRKRPLPLDENNADCVSMDPPNVKVAVRKQRLDLSEYADLNDFTFDDAYGEDKDNEYIFNSCCKELLATTLQGGSASCFAYGQTGSGKTHTMVGGEDERGLYILAAAEIFSSIEEDQEVYASLYEIYCNSLFDLLNNRSPVVVREDHNRRMQITGLTWHAVSSANELQLLISSGADQRSTGSTSANERSSRSHAVLTLQVRSRADSRFCGTLNLVDLAGSERAADTATTDRQTRREGAEINESLLALKECNSRPRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S9</accession>
    <name>F9W5S9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000763">
        <property type="protein sequence ID" value="CCD12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34040"/>
    <dbReference type="OrthoDB" id="1723461at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16405" checksum="6270DF5F18AF1107" modified="2011-10-19" version="1">MPRVVIVKPHRVTHSSAMAPSHISALKVWLCSNMKSACNKWAALALSQRTHAWPSLLRSLPHYTTGGSICCRGVQPKSAGTTHPSLLPTLHMSLSAASSVQLLTGISHSAVARPAVQHSNKLHPELLRCDGHYSQSHSAAHLQALIQGHFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5W2</accession>
    <name>F9W5W2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000786">
        <property type="protein sequence ID" value="CCD12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34320"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="20123" checksum="E4EC7645D026DE81" modified="2011-10-19" version="1">MSESPSSPSPEGMARENTPWSMEKDVVEVLLKGIGDPEKINLYRFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLSLKLVYYAGPPEGWGPREWEVWREFLKLDETEHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W648</accession>
    <name>F9W648_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_35120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000821">
        <property type="protein sequence ID" value="CCD12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35120"/>
    <dbReference type="OMA" id="SAIKSAX"/>
    <dbReference type="OrthoDB" id="747690at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388717" evidence="1">
        <location>
            <begin position="28"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="119"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="778" mass="84759" checksum="7830DB1A601AF702" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9W657</accession>
    <name>F9W657_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_35210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000824">
        <property type="protein sequence ID" value="CCD12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35210"/>
    <dbReference type="OMA" id="PIKRLMT"/>
    <dbReference type="OrthoDB" id="1412570at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17771" checksum="EE6FCBDAA7472026" modified="2011-10-19" version="1">MITSVGRLTKELHHVQRSPDADITISLPDKTNILLWEAVLSGPPGTPYEGGRYRLMLQMPRDYPMVPPVAKFITKVFHPNVNFDSGDVCLDILKNRWSPAWTIRSVCRAILSLLTDPDPSSPFNCDAGNLLRAGDLMGYNSLVRLYAITQAGATPFNDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W696</accession>
    <name>F9W696_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1439</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_35580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000840">
        <property type="protein sequence ID" value="CCD12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35580"/>
    <dbReference type="OMA" id="DKPIVQY"/>
    <dbReference type="OrthoDB" id="1337265at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="PTHR11782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="414" mass="45509" checksum="996EDBC17BE2C762" modified="2011-10-19" version="1">MMLVVFSACNVHQSTGSAKPDQNEACPRDLPSRYDILLDAGSTGTRIHIFEYNSKQLLRETFDSVTPGLSHFARGDPGGAGKSIRKLMETALNAVPASHYQCTRVALKATAGLRLLPLEKSEGVLREVERTLRKYPFVLDSVSIMSGEEEGVGAWLTVAYLLGLAEGPATGSNSTTLRTGVAVFDVGGASAQVVFPVPSGYKGKEQQISHLRYGGEDTLLFRYSFLGLGINQAILRVLLRLQPDERSVFSCLPSGYRHFVQWGGEAPFVVENVDGKMQEFGACLSHFNSFFKELPSDQLTVIEQMRSLMRLRSSSGPIDMFGLSFFHHLLWRFNKSEVVTVKRYRELGELTCSASARQDRATTCMDLAYLYSFLSTLLGLNDDTTLNVPDKLRSVKASWALGASLLSAAAKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H1</accession>
    <name>F9W6H1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1466</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000869">
        <property type="protein sequence ID" value="CCD12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36290"/>
    <dbReference type="OrthoDB" id="1655084at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="530" mass="57874" checksum="29A06615AA06E503" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J0</accession>
    <name>F9W6J0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000881">
        <property type="protein sequence ID" value="CCD12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36460"/>
    <dbReference type="OMA" id="SIRCGHA"/>
    <dbReference type="OrthoDB" id="1701627at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389933" evidence="1">
        <location>
            <begin position="22"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22250" checksum="AABEFFF07DB65966" modified="2011-10-19" version="1">MGPGSRFALLFLALMVCGVCGEGVSFHGRESRRVYCAKVMNVVGKINKHYSDAWQGVEGAVARIKSLSIRCGHAVPRVEPEGRNSLGATDKETLMEPLHFMIHDTEKQIESYDKKLRELVNEVVGRCDFWLSFMPITPTFKRTTKSKLLEARSLLRFVEELRGKVESLVDKTEADMCVEVNDAGGSAMEEEYDKAGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6M4</accession>
    <name>F9W6M4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000896">
        <property type="protein sequence ID" value="CCD12831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00320"/>
    <dbReference type="OMA" id="EHTIREC"/>
    <dbReference type="OrthoDB" id="119789at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="60"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="729" mass="82277" checksum="581CFB2D8918A5C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U5</accession>
    <name>F9W6U5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_37400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000938">
        <property type="protein sequence ID" value="CCD12902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37400"/>
    <dbReference type="OrthoDB" id="1669238at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389870" evidence="8">
        <location>
            <begin position="25"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="96"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="390" mass="43168" checksum="B52A1E0398001331" modified="2011-10-19" version="1">MIIKTSSMLWSMACMLMLWSDVLCAVSYHRQSIPTEAGESICSLSRNLKAVVPWTQEKISALRKTRDAYASKLLDWQLHFHGSSECGVNESILEDIRTELETVNKELQKLSAKAIRAGALAAKSAGRLDEFITVFANARKGSFIGTFNYCLGNKGDPARRRDLLDCFPEGEKLEIGEANLAKIPETAAHKEEPHLRAAINNVNHSACARYFNRIHGEDIHAGCNLINATSGFLGSALQDKLWWGGGILTIGKGFSGKMNRTTFIAGEATDAPGDNSKAFWTERPSEKIPHLQKTLAAFQVFKDATTKITQKFTEIEKIEKQIEPCLSNETMEEGPTQSCFKNAVNLNAELQAANALLARYHKEKGPLPSGSHRTHARCVFTFCYLIAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y9</accession>
    <name>F9W6Y9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000949">
        <property type="protein sequence ID" value="CCD12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13405" checksum="4FE7EF8D7A79F960" modified="2011-10-19" version="1">MSILSLHPNPKPFFCAFVSSPCVCINMKSTKGASSYWITFLSDYNPSLKTMERKKKRAPSVPLLLPSCQSLMHVYTCFSIYACTDVAVSWGCCSSTSLFPIHCFFLLIMSVFLVSFFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z4</accession>
    <name>F9W6Z4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_37730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000952">
        <property type="protein sequence ID" value="CCD12952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37730"/>
    <dbReference type="OrthoDB" id="1672825at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394588" evidence="5">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="38585" checksum="C86CE92EFAB5D686" modified="2011-10-19" version="1">MMKVLFFVIVSILGVVNATADKEKDHNNKAHKALCDLMKAAVGKWGDGGQGLSKPLKKALGRTLFGKVEGGDLSDIKGLPKDYNEVEGTDSSRGNWCGQPYEGGFNGVNQARWAGHSAPHDMVCLCTVGEKGWPLNESDNRIEKLCGLEKKALEAEDNQGWGYTKHEGNKHVTATWTKIVTPCLEEKVGKDLKQALNDFLRKLVNKSSDFYSNRFQLGEGDPYDSYACTGSATYGVCVEYYNTTGLWYPMPWWVDLQKALPEEEKFQEEKKKLEEEERRRHQEDREKTNPAQTEALKSTHTSTNQTERSQNDNITDKLRRLNLTSGTPISLPSSWLLRAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z9</accession>
    <name>F9W6Z9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1542</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000955">
        <property type="protein sequence ID" value="CCD12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37760"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="241" mass="26971" checksum="E0B165163077EF63" modified="2011-10-19" version="1">MLGEEDTQAITLLSVMNKIAAYKDYHPSVGNSSGHRTSVLTQVNALGRIPSAVSFFPRGRAIPVELGQFYRPLIHNFPVVDGFFLVDAVGKGVLLPEGAAAPTQTIVLLQVTKAGCHHTTTSEVGRFRELMAQSFTNWREMENRLSYEMIYVQHTDSTSITERQRCDRSGMADDAVIEEFWNRLSHFQVAFDLPITEMFEGKLFGRSVTEVGANNVRRGMQTLSMEPPYLRASLPYSGMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W728</accession>
    <name>F9W728_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_38050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000969">
        <property type="protein sequence ID" value="CCD12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38050"/>
    <dbReference type="OrthoDB" id="1676858at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389949" evidence="5">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="37417" checksum="65721DF92074437C" modified="2011-10-19" version="1">MMVMMVWMVVMVFFGVAASEDKKDYNGPQHRALCGLLKAAVTKWGEVHGREPADPLRKALGQTIFGKVEGGDLSVLKVLPTDYNNVEGRLTSRGTWCGQPFYETHTAHGWRWSGHSAPHDLVCLCTLGNNTWPLNHTQKETTLCGKDGNALGGSDGKGWSNGGSGNEHVKATWVKVTVPCLNGEAGGDLKQALNEFLGKLQHKPDGDINPSRYILGENNVTETDSDACTGSPKLGVCVAYFNATSPMPWWVALQNALPEEEKFQEEKRREEERRKKQEEEQNQEFPKAEALRSGSPTTNQTEQSHKDNITDTIRKFNLTSGTPISMPSSWLLRAVFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W790</accession>
    <name>F9W790_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="1">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_38710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01000999">
        <property type="protein sequence ID" value="CCD13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38710"/>
    <dbReference type="OMA" id="PHPSVWI"/>
    <dbReference type="OrthoDB" id="451519at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="PTHR45700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="610"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="924" mass="104463" checksum="8D4998557C590B41" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P3</accession>
    <name>F9W7P3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001060">
        <property type="protein sequence ID" value="CCD13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="31"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="41267" checksum="7DF93ED4BAEFAA0E" modified="2011-10-19" version="1">MEVLFNATTDNMDNFRGTLWDAKDFFEAHPPPTDPKNRREAHREIGQLIARGEKEIQDNRGIAVKVNEKIEAARLSVLQGLYGDGVKEVPKDEENLTKILENSSSIFKSVTSANESCGNERETGKTLFNDLFCLCVGDGDQSKNPHSPCSANFVSPQNGNGYNKGKWTQMKPGSSSQPALPVAKSIEKIMEECKKNKEENSMKKGMSELLKDFEEMIGKGDDQVKTDKSKKIFGHSGRGKGKGEVKECDGTVGSNNQGENSEKYNEKKICVDYSKHLKDNKYDIPWHNKFKNYTTIMKEAKSLEEKILKNRADLLLLKSQAWVAYSREKDDETSNLDDMNVSNLFDGARVPPSFPFPSLLLFLFMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7T1</accession>
    <name>F9W7T1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001078">
        <property type="protein sequence ID" value="CCD13253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14588" checksum="0456A1FEF1D1EEC0" modified="2011-10-19" version="1">MQPGKQIICTNAGNNKTHFQCISQHHNTPAPCRSQKSQDGQQVLHSFGLHHMPRVLGCAWCRAVVVIPACGNTRGNCTSAFYFILPRGSTASRQPPHCLAAYDNGERCDTSHQTPQNAVRSSHSHIWPHTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W816</accession>
    <name>F9W816_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001121">
        <property type="protein sequence ID" value="CCD13342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04410"/>
    <dbReference type="OrthoDB" id="112609at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394601" evidence="1">
        <location>
            <begin position="22"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="513" mass="55939" checksum="CEE19FB0DD503E56" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W868</accession>
    <name>F9W868_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001142">
        <property type="protein sequence ID" value="CCD13396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00380"/>
    <dbReference type="OMA" id="MRFARFE"/>
    <dbReference type="OrthoDB" id="365272at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="574" mass="64771" checksum="E26C03CEC22C20BA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W894</accession>
    <name>F9W894_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41750"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20038" checksum="9DBCB76C9DC95EF7" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYPFLQPAYPFIHSYVSRFSITDFARNPWRCVGEADGREKVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B2</accession>
    <name>F9W8B2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001156">
        <property type="protein sequence ID" value="CCD13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41930"/>
    <dbReference type="OrthoDB" id="1675376at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394769" evidence="5">
        <location>
            <begin position="23"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36599" checksum="6F0C43FEBF73F26D" modified="2011-10-19" version="1">MMLIQFWKIIIVSMWVSANVEGTDHNHDAHNALCELLQSAVGKWGDGGKGLSEPLSKALNRTIFGNESGGDIAELRSKLPEFYDEVLKGRGTRFGPCGGRESGQSAPYDMVCLCTLGDGGWPLNDTQTATTLCGQPEAALEGGKDKKGWSERGTGLDQITATWFNVTKHCLEGDKEKGETLKEALGNVLGKLENKPYGGYNRYQLGEGTPTEWSACTGYPPLGVCVMYYNSTKITKTMPWWTDLQNAIPEEEKFQEEKKKREEEEKSQKQDSSSIPGENSTLSRRRRAVPDSPNENEADSNLTAKFEKLQSRSSTPIIPPPSWLFRAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L8</accession>
    <name>F9W8L8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1746</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001182">
        <property type="protein sequence ID" value="CCD13552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42940"/>
    <dbReference type="OrthoDB" id="1662834at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38015" checksum="8D5494D818EAF651" modified="2011-10-19" version="1">MFDVAEEEVERCLCEQKETTKAIQVAVCGLRESFEASRSDDDFRSIGFSIGAAAPSDNQSSDNGFTACVDISGYVKHYKCLGVTLKEALDMKGKSTRGVNGDDRITGSALKTMVREAADHTTQLADSLALLQGFSVGVVTYLSVIWTLFAHLEDIAVSNGDGERTQLDRTQGDPTGMTGATLRTLTRNLPIYVARESLRRRVRLDWDWYRPPADILIVLLGCIFSVFSGPVHTSYGSTEPYCYIAVAAVIITSILILAGWPLVPLCTPYLKGLWRRMRGRQHKPRGVSEATCPVDGEQYETFMREYGGGSVRGQQQMPDDPGLSHGAQQEARGTRMLFDPSVNKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W903</accession>
    <name>F9W903_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1806</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_44260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001248">
        <property type="protein sequence ID" value="CCD13692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44260"/>
    <dbReference type="OrthoDB" id="1148693at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="433" mass="48598" checksum="F8CF1F2A4327FFD6" modified="2011-10-19" version="1">MRSDRYDVEPAVQAGPNDLVKCKLHGTVRMAKYCHSSAVCNADQVVIDFTYECKERSRCAGTTPSVGELLNRKPIKRNAEGREEPVSECKMEVMVSEGMSSAGLSTIAEGGKQPEGTQRGPSRYYDLAAQRAQGAGPMKKVCWNCGIEGHEKPNCPNMLCRYCHGVRSQNHFCQESRPSPFIVMCPTLQFSEEMSAVQCVSCSALGHFDCTTAMSGVIPSCCFCGGKGHSAFDCIHRKESAVDHWVARMRVSEGGPVSKNYEWGSNNAGYHASTPHFRAEQNRSYSGGGIGGSYGRDDTRSTNVASSYQSRNRNFDESSRGQRSAPHQTYDDGFRDREKRSLRGYGEKVYYRNDDGMQRSGNWQDQQHQRQQYRYDGGNGNASRQMSQKGHVSDRSRVQRTSFSRYRQVQRGEPTNSRLRNISENDEYYDSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W952</accession>
    <name>F9W952_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001262">
        <property type="protein sequence ID" value="CCD13742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14850" checksum="D49921A06C45D236" modified="2011-10-19" version="1">MTQPASGAPHVCHSCLTFRITTVVSRKQLQNVFQKKKDAGSNLHEESMIYAHSLPSCAVAMWWLTYQCEKGSTFLVAHRCDLQLHVIHFFEFDFIFTNAHGLRSPDCKTYQPLVFVQTHDLSIGMWYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W996</accession>
    <name>F9W996_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1839</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001285">
        <property type="protein sequence ID" value="CCD13787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44880"/>
    <dbReference type="OrthoDB" id="705556at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000079">
        <property type="term" value="P:regulation of cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="entry name" value="PTHR15615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="27843" checksum="088F02D23494E651" modified="2011-10-19" version="1" fragment="single">MGKMSEYKRSLSERAKRRMAQSDRVDVPTPSYRRKPAISDYFTEGRLRAMCDEDKHGESWGLVKRHSGVGLNTGSTAASCVGCCHHLRNGIDANVSGLWTQRRWRDGGILLHTPSVSEPVRHGPSAPLNEASSLQVKHAGEYEVIIPSVGHALQRVVQAHEKWLQETVSSPAAAPLCGGATSRVKGINRNNAGINECFKAFEKTVGPSVTLPDFVRMMVERTLISPSVLVVACLYIDRLLLREPSLCLNMNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9D8</accession>
    <name>F9W9D8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001299">
        <property type="protein sequence ID" value="CCD13838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04900"/>
    <dbReference type="OMA" id="MARCVEE"/>
    <dbReference type="OrthoDB" id="1670984at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388868" evidence="5">
        <location>
            <begin position="22"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="44726" checksum="1D3DA90CCBF3F34A" modified="2011-10-19" version="1">MYWRGVALFFLFFLRPPTGLAKNENEGESEIFCQLRLLAENDPEKLVFGNEEREKQILRRIEKVGPEIRGLSGQAHTREVSLTAQFNGIAQEAKKLMGTVRDMRRKAVEKRLSAKRHLHQVIFGEYVGNETVELGQAKETIRKIFSSTTFTESCGGKGDKPTGKSLINDFICLCAHWFDPKNDDQSICKSRVDTSVNPNFSNWTAVWHWNNHRICVNTPPLTPTPQNIHKLVALFERAVERNQTGSQVKGVFGYVKDDNTEKICNGSKVSFTCVNYNYTLKNGGIEWVNHLKNASEDLQDMARCVEESESSLPQLELLEYNALLLYEEAKYSTHLPHITPSNETDTNSSNESYPGDPTNTSEEDKLEEEDSDATWKGRPPWWGLLFFFLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9F9</accession>
    <name>F9W9F9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001304">
        <property type="protein sequence ID" value="CCD13859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45500"/>
    <dbReference type="OrthoDB" id="1734808at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390002" evidence="2">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="28139" checksum="CF96717A0CA7B3FC" modified="2011-10-19" version="1">MMMKFWTVLYLCVVGVIADTNVKNYNLEEYNALCNLLKIAVYKWSDLKSKGSGDPLKKALGRTLFGERDGDEVQSLKAPFPKDYEKVIGNHGTRYFWSGQRRKENECSKERRESRRRKKRRRRGRVQRKRRRRRLQRRRRVRRRSRVKYRNMRKEREKKRHPKKVKKKSKRRLMQWGKQNRVVVTRIPATTMMRLVRRMGRLMRSTTSKGVWTVNYPRHVCSLLRRTALSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9V6</accession>
    <name>F9W9V6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001354">
        <property type="protein sequence ID" value="CCD14011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05010"/>
    <dbReference type="OrthoDB" id="1708638at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24935" checksum="2A283FD7D9AB5284" modified="2011-10-19" version="1">MPCPPAHAYTVWGGREHFRTSSIHKSKVVSVLKRKEGKEAMAADQLHHFVPSWVSADFHLMLMLGQNTPSSNEKQHISNAFHGLVLRTTCQHPAAVSSTHDDIVTTIILQTIVLANHEAVAMKCTTEAAARLQAQAARLAILNHTASLLTADTGTATVARPIALQEFLALQVGAATWTAARTQAKARLAARGHKQARLPLIDSTPILTGCLICKATTTFHMWRLSVTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9X8</accession>
    <name>F9W9X8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_47130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001363">
        <property type="protein sequence ID" value="CCD14033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47130"/>
    <dbReference type="OrthoDB" id="966768at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="SSF47943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="28138" checksum="E9F238FCD6542582" modified="2011-10-19" version="1">MEARKNVLGEDGTPTALPNLMDEAFPLNRPNWDYNTAEGRGCLLVYRRTLVAGLRGAARWPTNLAKVREVLQGQTEPPSVFLERLMEAYRRYTPFDPSSEGQRAAVAMAFIGQSAPDIKKKLQRLEGLQDHTIQDLVKEAEKVYHKRETEEERQEREKKEMEERENRRDRRQERNLSKILAAVVNDRQSGKGKTGLLGNRAVKPPGGRKIPLEKDQCAYCKEKGHWARDCPKNRERSKVLTLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA12</accession>
    <name>F9WA12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001371">
        <property type="protein sequence ID" value="CCD14067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14463" checksum="8213825CAADCF373" modified="2011-10-19" version="1">MPLRKTRSCHGVIWHRALVRPPGLSTGPPHITAPSPVELCHLNGSCGMRSQPPHPHWKPTTTEQGMARVVENFPSPAGAPRHFPLLNGRAAVRRLSGWKGRSSITFLKTLAHSILRHGHLPHHKPTGFMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH6</accession>
    <name>F9WAH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1975</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001436">
        <property type="protein sequence ID" value="CCD14238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48830"/>
    <dbReference type="OMA" id="QARDFYH"/>
    <dbReference type="OrthoDB" id="780748at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="22914" checksum="D46E0515A4D7B461" modified="2011-10-19" version="1">MQSEGTKGSVVEVKRTAGKKAKRAAEDLDQGSVGGDRKRISFADGLSGDEGTDGQHKPMRYPNDKGEKRPSEFYELVDVVRYGERVEAPPVFDTVPSRDAAISRLASKLGHVPERGAKEVTRGKPSERLQLLSSVGGVGERKRLERLGLLAADSSTVAITKKQMLSKKEEMERLRMSVVEAYRRNKRASFDAKKDIDMHHKFPRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU6</accession>
    <name>F9WAU6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2016</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001482">
        <property type="protein sequence ID" value="CCD14368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49870"/>
    <dbReference type="OMA" id="WAKRWYE"/>
    <dbReference type="OrthoDB" id="242001at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="753" mass="87250" checksum="585A35325FE3B3D3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBA4</accession>
    <name>F9WBA4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_51430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001553">
        <property type="protein sequence ID" value="CCD14535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51430"/>
    <dbReference type="OMA" id="ICPVIWI"/>
    <dbReference type="OrthoDB" id="1356321at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="PTHR13019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22602" checksum="80D4861647106B1A" modified="2011-10-19" version="1">MLAPPQPAAGNPQTPQFGSSNYVQPQQPAPALGQQPNMQESQPIYRGAHPITAFFHICFKVGSLLTFILGGLFSSSAISVFVFTILLAAADFWTTKNISGRILVSLRWWNEVREDGTSHWVFESASDPNRVHSFDKWFFWSTTVGYVGMWLLLVLFNFLSPTRLPMAVTGAVLGGSNLMGFLKCSQDAKKKLTQFVFTQAANHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBD6</accession>
    <name>F9WBD6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001566">
        <property type="protein sequence ID" value="CCD14568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51720"/>
    <dbReference type="OrthoDB" id="1699708at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="223" mass="24059" checksum="2A12C895BBDF9FF3" modified="2011-10-19" version="1">MGFSSFGAGGGSSIPKPGCRPEGVWEGQSIARLSSAELIPHPFPYPFTFAGHHFTPSLSFQRETGLISVGVSSVPWARPCFANRFTGPSMPLLSYVGLVFVASLPFFWRPPSAMPRSSSFRFIPHVSVFSPEYVKGSAHDSGPAVLIRFFLFLVSSPILLGHGLFPGALARLQPQRVPYARAAAKTMSECLNAQPQEGKAGGAGALKGAIRHEAWRLNHWKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP4</accession>
    <name>F9WBP4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2127</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001605">
        <property type="protein sequence ID" value="CCD14677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52730"/>
    <dbReference type="OMA" id="WHNAAAI"/>
    <dbReference type="OrthoDB" id="1624076at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="21906" checksum="3EE0A7EB7FAA516D" modified="2011-10-19" version="1">MSAASLLKELFGSPDIQLLRQNGETVSASAAISGKKYLLVYFSASWCPPCRGFTPQLATFHELFSAKHDFEVVFVSRDNDEAAMNAYFYNPQFSSLSVEGGEGSHGNWLAVPFKEAKAIGDNLKEEYEIKTIPTVLLFDLSTGNLVTQEARHNIADNFRTAEGFPWRRSPFAWFTPRRIIKICAAIVLLYYYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBS3</accession>
    <name>F9WBS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001623">
        <property type="protein sequence ID" value="CCD14707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53000"/>
    <dbReference type="OrthoDB" id="1673866at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394838" evidence="5">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="61"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="36930" checksum="87CD50C4C8DD2ADD" modified="2011-10-19" version="1">MNRTMKIWIIAFLCASVVGVCAQESGEPTGKTDHNKEEHERLCGVLKAAVGKWGTSGEGLSDPLKKALGRTIFGNEEGGVLGELKSLPDDYTKGGAIRGNFCGQPYSEPGFFSAPHRWSGHSAPHDRVCLCTAGDKRWPVNITGTTLCGKDKEVLGASGDHGWSGKIAGKEQIEKTWGSVVHNCLLGGGLGTNLKEVLGKFTNTLEHRKNKWYENRYLLGDNGSDDYACDGTPNSGICVVYYNTTDSKTWWSDLEKALVLDAEAEKQKKKAEEAERKTRDEAAKEDTLPPALTSSGQLTTNKTEQNKTATLQESIRRLNLTSGTPISQPSSWLLSVAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBS5</accession>
    <name>F9WBS5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001623">
        <property type="protein sequence ID" value="CCD14709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53020"/>
    <dbReference type="OrthoDB" id="1675104at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390123" evidence="5">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="45"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="320" mass="34674" checksum="049F2B8451F5A008" modified="2011-10-19" version="1">MIRLLVVLGVVFSLSAQSRGTDHNGDAYQALCGVLGSAVKKWVDVKNRSKDDPLHQALAKTIFGKKGEQDLEKLRGALPDEYHVVEGSDSSRGLMCGPPRTAEHVPYQARWPGHSVPHDLLCLCTPGETAWLTTIRGSGAEKLCGKDAQTFVDSEGWADNGYEGGVAQMTTTWLNVTVPCLKGDESAGDLKSVLQKFKDNLGGPVPGHPASLTLGEGDLRDAGACDGTPDGRVCVFYENTTHRFPWWTELEQALATEEQKRYTEKAHTPPSTSRHSSSLATEPKSPDSNASTMPRPERLRNNAPVTQPLLCLPGVASWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT8</accession>
    <name>F9WBT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13672" checksum="679B7A7D13C548AE" modified="2011-10-19" version="1">MANQCRGGYAISDERKKEIFPYSIPPCWGALVMSTPSPERFEHWVNRYQALPICINCHNNLEFKVVHALGRSPALCQEVPLTEEAVEGLKRDWDELELRAREVGPLIRCVLGYHLHSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC21</accession>
    <name>F9WC21_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_05660</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001654">
        <property type="protein sequence ID" value="CCD14808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="DNCASRK"/>
    <dbReference type="OrthoDB" id="445763at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="437"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="635"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1003"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD14808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1399" mass="152949" checksum="38CE5E8998A822BD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC60</accession>
    <name>F9WC60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2189</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001673">
        <property type="protein sequence ID" value="CCD14852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54290"/>
    <dbReference type="OMA" id="QPLFHLG"/>
    <dbReference type="OrthoDB" id="1221144at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="25238" checksum="12628BEA31EEF4A3" modified="2011-10-19" version="1">MGSDDVRHLTLGEQMHVLRRLAKVFRSSVVLLRTLAALQLLLSFLYVCLLFGGHPLVYAAFDSHDYSGSAPLIEPTPLVLSTTGTLSMLLSAILLVIGGLCDLHTCRSVLHVDLSIIDGGDDAVHTAYRSPRRSPYDAESGEPCPRHQFVLGLISLLPATYWLYVLVSHRLYMAAKGVYMFGIRDNWWELLLVAWQPVIHIGIDRMSVSMISSKEEFIVLAHMKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC78</accession>
    <name>F9WC78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 2194</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_54440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001679">
        <property type="protein sequence ID" value="CCD14870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54440"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="318396at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="8">
        <location>
            <begin position="53"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="246"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="631" mass="69886" checksum="2FFDEF41FD310A7F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCX9</accession>
    <name>F9WCX9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001784">
        <property type="protein sequence ID" value="CCD15127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56870"/>
    <dbReference type="OMA" id="NCTPRRT"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="461" mass="53153" checksum="43C39A73EFF8812B" modified="2011-10-19" version="1">MYATHANARYIGNRKRQSDGMQEADSRGLRDAVGPDAVKRLEKALSAARRVEENRVRVMPRSAEVINGLYDSVYNARWRCVITGKMYKNEPFGMKLLNAKTEVPCLWSRGDVDMMPELGQSYDIEEMLVRSEKVPVVAVLSSALGWPNRMHTPQQPLQALPAPQGESDDYTHLYIRKEMMRVWYIIEEELDRWLKPDECRMPQYHIVIGTAGIGKTRGLGPFLLYQLLHYSSEKLCAIAYFSKGEVCILHRHKGDTPGMAVYYNVQDGVSEIERMATQCRKGYAIFDEYKKEIFPYSIPPCWGALVMSTPSPERFEHWVNRYQALPIYINCHDNLELKVLHALGRFSALRQEVPLTEEMIEGLKREWDELELRVRKVGPIIRYVLGSHFHSRWEDVERVLQDSSHQCRRYSSGASRYSINWKEHAALFKTTRYMMEGAEVGICEPVSVAVHKKRNSVDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD31</accession>
    <name>F9WD31_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001814">
        <property type="protein sequence ID" value="CCD15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57280"/>
    <dbReference type="OMA" id="QYVALIW"/>
    <dbReference type="OrthoDB" id="1476123at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="PTHR23137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17253" checksum="1057717D71FC788F" modified="2011-10-19" version="1">MEIPIEVVGSSFSDGDDGEQCFKGLSWATRMKGYLLCTALGLLCSAMACVALSIGYYWKYSVLTTLGSVISLGGTFILKGPVAQVRYMFDEYRRTASTVYLISLFLTLFVAFRFKSFLLCVVCGIVQYVALIWYSLTFVPYGQEALGSCLRGLFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC8</accession>
    <name>F9WDC8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2352</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001856">
        <property type="protein sequence ID" value="CCD15281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58120"/>
    <dbReference type="OrthoDB" id="1719815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17374" checksum="770BA5223F11F3C4" modified="2011-10-19" version="1">MTTYSPCTQHTAGIGNSNAVTLPSALVCCLHSVLRSTAHTATPHLSQPPFNRIVRSSSHTATEAALTAYFHFTANSATEFHSILKLTHTPVSPNDTHSKHHPLIPNEATGFTKLQGLYATRGLEFGFPARLGRLLAREGYFPVCPYISHRLFMLYRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDE4</accession>
    <name>F9WDE4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58280"/>
    <dbReference type="OrthoDB" id="1667518at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390208" evidence="5">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43810" checksum="55076BFCC20846A7" modified="2011-10-19" version="1">MMKLFMVMMVVMGSWVREWRVMANTEVSVKEGDNREYFSLLCKIYNVAQHPPIKPVDTKEYQKMVDDINALSTAVNGKEGVNTKSEETRSAQTQLVGISQDARKLLDEIKRENPEGEAGKARLTFNQVIFGKHGKEDLSPGALEVVDQRMTACGGKEKVGKSAGKNIIVDFFCLCAQNNEDNEGIANVCGVSVGSGDGTGWGTSLKSIATMWGEIKQGCEKFAEQDVTSTQGGHFLFREFLAKVKAGGNVKVKDPGTIPQHGMLGTAVTATVNSNFNCNGKNEVSTSRTTSSGAGVCVFYGNHHRKQNIAWLKKFKEGLQLIDKLNTETAAWQHQLTTLLNRARELYEKVKANTQQEEEDTEESPLTQHPNPDETENTDSTTQSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDG7</accession>
    <name>F9WDG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001864">
        <property type="protein sequence ID" value="CCD15320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58510"/>
    <dbReference type="OrthoDB" id="936170at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="520" mass="57407" checksum="ACBD596F79483C4A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDI0</accession>
    <name>F9WDI0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2367</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001872">
        <property type="protein sequence ID" value="CCD15334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58630"/>
    <dbReference type="OrthoDB" id="1718106at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16912" checksum="CD4D8279532FD394" modified="2011-10-19" version="1">MPLAIRYPPHTRFPCGSIGHVVPHYYNVPRSPEWVTFEHLWECHHSSPQWRLWHAGEARDSCFVAVPFLPTCWLSPMPAVTPLNTAPVGTCRRRNRAPNAAWGQPALWDLRPPFRTVQLTTSALVSALPPIWKAVSSCTELHCSLQAAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ9</accession>
    <name>F9WDJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001878">
        <property type="protein sequence ID" value="CCD15353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58800"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394901" evidence="5">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="43"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="371" mass="40787" checksum="3B3A45DDA9075269" modified="2011-10-19" version="1">MINIATLLLIWIGVGTWSGDCGVVLRASGYNEAVSTLLCDVFKAAEAVRKHANVTEELKDKIKVAVYGPSYGAQFTEDGRLSSGNRFISGTQYGRQTVCEYYNRSTRAIRVNGAFVENLFGTFVCVCTPAVTSRHETLCGVLHGERKRTWLGNFNGGRVGNALLQDLWQNVISKCTSDLQNYEDDMTRASKLYLALAAVRNQIPIRRAGEKLVYVLGDARDLRGCSGRDGKDICAAYEYALGRLGIPWEKKLRDLLPELFTQVDNTRETKIEHTVPSRPPVPGTTNSPQPPLSREVPVDEEGEPTVNEEPPGDVENAVAVRGSETQNRESAGEPLEETVKRSEGSPTSQRTDIPYLSTDIHKGGSPRAKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDK3</accession>
    <name>F9WDK3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001879">
        <property type="protein sequence ID" value="CCD15357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58840"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="189"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="472" mass="52426" checksum="2F475BFA6933F129" modified="2011-10-19" version="1">MVSGAVALPPRQVKLPAHRPMAGTAIIIIIVNAFFLFSLFSLFPHFHFLCSSLGFSPYVFFLSLITLISYIIIYCYYYIIVIVILLLLCYCGIIVPVAVTAAAGVQLLVAPVAAQAHAGTFPVRLVLTHISLLPLSARLREPPSLADKRFSHDTATTPAAKMTETFAFQAEINQLMSLIINTFYSNKEIDFDYEVWTDRSVVLDVSSGAGALVYPKEGRREKVVLGAGSLACSYRVECVAMEAGLKRLVDVIELNQTHRTRVVALTDSLLLLVALSTGPAVVEDAILRRIWDLILRLVRLRVSVNFQFVFSHCGVPRNEAADKAAEQGNAKPQMYPAWVTDIVTGVERQVRNEMYRSFEEGRMLRTHRSVLLDHVRPAPKHTKLDRLGESLLAQFRTGTSKHFGWLHRVLTRKTDRLECRWCRAKDIGGDAVEGHTLAKPAVDSANAPDLGIATRQSDPIICPLCNMVCARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL4</accession>
    <name>F9WDL4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001884">
        <property type="protein sequence ID" value="CCD15368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58950"/>
    <dbReference type="OrthoDB" id="1710127at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21134" checksum="39AB29E32DB4207C" modified="2011-10-19" version="1">MSYYTITSPRTIPWSMEKDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAVWQYLPYLLWKFRQSATPLVKHFGPTQTWKKWHWDSWKIYYDNDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVLVGATASFVQVPYSTVGYLVPIPLSPGSWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE63</accession>
    <name>F9WE63_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_60550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60550"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389026" evidence="5">
        <location>
            <begin position="21"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="46"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="44951" checksum="DD732CEAB1D71E96" modified="2011-10-19" version="1">MNRNLATLLVLWLGSGAWWGMEGAQARYRPRNEKASTLLCNAFRAAEGVRKYTNVSQNLKEKIKQAVYGNQGKAHFPEDGKLRYSGWFSRRVQYPRKSACEYYNKDFVGRQTDGAFAESLLGAFFCVCAPPITDKNTRLCGVYHGSQRGAWSGNFGRGRVDYLLLQDVWDRVISQCTASTKDPETNLARVRKLDMALAAFRWGIRLHSTRTEYLYILGDIYDIQGCSGRAGNDICAAYHQQVGRWGIPWEHTLRHLLPDLYKQVGYVSELTKEEKTVPTTPSHTSATVGPHETYGTHGHQETYMPPLPSREVLVDDEGHAVMVQDDDFPEDLPNSTEAGWEAEENETSNPVQGPIPNPTSDLDPTSPEAAEGIVAHLTAAAHEGGASITPACAWRLFTATVALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEH5</accession>
    <name>F9WEH5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_06990</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002013">
        <property type="protein sequence ID" value="CCD15685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06990"/>
    <dbReference type="OMA" id="PLIWIWL"/>
    <dbReference type="OrthoDB" id="621852at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044566">
        <property type="entry name" value="RMV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826">
        <property type="entry name" value="PTHR45826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="511" mass="56028" checksum="2A3115109BC629E9" modified="2011-10-19" version="1">MTGSVGNNAVTERQYFEHPRCHLFRQARGEPDNTIGSLSADIEGQPADGQAPSATDKHGPEKSLSPLILMGLMYTYTTSGAYAIEETVLGGGPLLGIISIILVPLLMAGPTTVVVAEMATAIPSNAAYLMWYCIAFNRVVYFAMVLLTLLFIFIDNALYSVLISEYVCTAVTCSDAATKLLRLGMVLITYSLNVMGVQTVGRLSIALSVVTVTPFLLMFSMHMIKSNFYLNWPAISYIPTKIDWATFLMTTSWNLCGLEHAATVVEETKAPQTTFIRALVPLLGLAYLTYIPPILTGASMREGMPDLSEWTTGFWSHVAYAVGGVPLKVIMIVASALSAHGLLLSSLCTTTQIISGIAYSEVFPGPINRMLYKRNKCFGTFHWTLTINALLSALFGMFLDFGPLIKVNQVFYGIRVLMIFVSFLILRYRYPYLERPFRVPLEGKMLLLLIIPMLLFAGLVVLGMAESVESVIVNCSVLAATIVISLVYCLLIRKEGFYGRIVTEPLTGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM7</accession>
    <name>F9WEM7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002037">
        <property type="protein sequence ID" value="CCD15738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07500"/>
    <dbReference type="OrthoDB" id="257131at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="19853" checksum="637D7111289DFD31" modified="2011-10-19" version="1">MLKAQVEDARVDSMAAKGRARSLQYELLASQAAAKEVRRRGGCAPHHCVEAARVKLRRFPGPADNSPSRLPLRVLNELRDILDDGNVNHFTTAAVAPRGLDFQHVLPASLSQGGEADETPAKVKRYDDTHTEKRKGKPKYVDPTDVSPCTTFFSNDSSNNFTSLAEFSDSENVPDSTFHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEW7</accession>
    <name>F9WEW7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_08340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002071">
        <property type="protein sequence ID" value="CCD15833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CTRITHA"/>
    <dbReference type="OrthoDB" id="491869at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="22087" checksum="82B154DA24BDCE1C" modified="2011-10-19" version="1" fragment="single">MIRESLLRRFRKSGSVLVNLHASEMSTPDRLTVNSKNKKELKTPLCIELISKMTSQGYFPMSQYVKECLTHPRHGYYSAKKTVIGGEKADFITAAEIPFFADVISAWIMDAWQKMGTPRVLHLVELGPGKGTLMKNILKQIKYSNPHLLHFLQIHLVELGAARTEEQMSALSEFQTAQKKIKWWMGLESIPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEY2</accession>
    <name>F9WEY2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_08450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002077">
        <property type="protein sequence ID" value="CCD15848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08450"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394966" evidence="5">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="92"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="46201" checksum="24B9AE60A2615F21" modified="2011-10-19" version="1">MSFFKNVVAFLVVAVGSFVMGQVEVSKEDNIEPFALLCRIYNVAKNPPVNHVDLQEADKIVDEIDTLNKSLLEEKRLNEEEDAGNNSEAQVKPTVTREAALLQLSLNQITQRAHKILEDIKRMNVTEGIGNAKAEFNKVIFGENGNESDLCHATVKDVGDRATACGKPGDGIKGISAGKNLVVDFFCLCAQRTDDDGVNQVCGFYVGRISHYYGWDDKNGPWGSSTMWASIKGGCGKHMQQRPKSTAEARHILDQFLKHLKTGGVYRWGSGKVEGSNRKEGMLGTGVGKNENNSNGPVCDGKKGKSNPPGGVCVYYGTEHFEGNIPWLRSFNTALASVDTANNQTATIKQNIEKLQMLQHRAEEIYETTKVISQTKNPVGLPAAFENASGNLTAFNATRIRSYGYRPHTYFTALWVLYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF09</accession>
    <name>F9WF09_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08690"/>
    <dbReference type="OMA" id="MREVKNQ"/>
    <dbReference type="OrthoDB" id="382118at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="797" mass="80882" checksum="92315E6669B61269" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF22</accession>
    <name>F9WF22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 339</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002091">
        <property type="protein sequence ID" value="CCD15888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08820"/>
    <dbReference type="OrthoDB" id="1709449at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024744">
        <property type="entry name" value="CSS-motif_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12792">
        <property type="entry name" value="CSS-motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="CSS-motif" evidence="2">
        <location>
            <begin position="39"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20024" checksum="CDECA8856124E4B0" modified="2011-10-19" version="1" fragment="single">MIKLRTNGDRWFVAFVACVGVVITIFLGQLELVRLAYVRLNDYRDNLLSHSLNVAKSGRDTLLIVNNTSQTLCSDDNLKELRLLTFKAHYLRDIGRVLNNRIVCTALWGRLSPPAELPVADREVDGGHRLWGQAADIGSHLTKVDMVMHGTAVVFTSPVAFALYERAQPNLSAHIISQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF87</accession>
    <name>F9WF87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 360</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002115">
        <property type="protein sequence ID" value="CCD15955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09410"/>
    <dbReference type="OMA" id="FNTGEAQ"/>
    <dbReference type="OrthoDB" id="1675690at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="34053" checksum="077628AF02684176" modified="2011-10-19" version="1">MEGGGVKRARDEMGGEQPHLWSEKQADAPFDPQEPWEGDVVPGVEGRLVMAVLSSEKGWPHTLFNTGEAQKEKVDSLTGNNAVCDAYIRKEGLRVWNIVKGRLNEHRVDLDPFIVIGTPGIGKSFATGSLLLYQMLHYKPEWLKVVAYFVKGKAYLFHREERRVVSYRKQQVAVDEIEGMIRRGVKGYIIFHMGGSDAIIDHLPRSWGIVLISSPNVSKFHDFTTQRYHTVPIYMNCYEDAELKAALVWERHSQGKKQVEKENVDAADDREVLKERIDMVGPLPRYVLADKATYEKRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA8</accession>
    <name>F9WFA8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1728734at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15342" checksum="105CAD5AFE077490" modified="2011-10-19" version="1">MSNCGVTSELHAAHCEGACVRPVCAGHGGCVWTLDSTVEEVLLWKYGNVTEAHLHKFLLDHFGSTFGLPDMSLIAFMNDPSLFVTDTQVLSGITSSAAYVDLQEMLRAVNVLNSAGIITLEQWSALSDAPAVVERAAATTTSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFB1</accession>
    <name>F9WFB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002120">
        <property type="protein sequence ID" value="CCD15979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="629709at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="15562" checksum="BDFAA00162FBC766" modified="2011-10-19" version="1" fragment="single">MTHVTLRGSFSDCSADYRVLSVSTEYLREIKCRVGAASERKCGESSVNRGESVQLGQTTLMTLKGGNQLLLCDDDQTFRVRRVEYSNTLLFAEEQPIEAHSPSAGAEARVTPSTLSGAGGEKKHVVVCSAERVFETKPAVPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC1</accession>
    <name>F9WFC1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002125">
        <property type="protein sequence ID" value="CCD15989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09610"/>
    <dbReference type="OrthoDB" id="1724760at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17356" checksum="0F5FBF4991E75AC7" modified="2011-10-19" version="1">MAGVLRHYTCEAAPKTLPPSHGAQQSKGPYDALQPACGGFGATSSESILRTRGMFSDVSRAICTRRDWLSPSGITSNLLVSSNAAATPTAWQTTPNGAVLKGSCICSEACSDLPSTHALNHRMVCKNNTKTGRGIQQRQENKRGADIDMLPYKYPKPSNCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFE5</accession>
    <name>F9WFE5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_09840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002134">
        <property type="protein sequence ID" value="CCD16013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09840"/>
    <dbReference type="OMA" id="GRFTWNC"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394984" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="887"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1244" mass="137342" checksum="E82BA44C7C9C0D2F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG52</accession>
    <name>F9WG52_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Very-long-chain 3-oxoacyl-CoA synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_00001</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="CAEQ01002232">
        <property type="protein sequence ID" value="CCD16286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00001"/>
    <dbReference type="OMA" id="WMQENWR"/>
    <dbReference type="OrthoDB" id="1094172at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102756">
        <property type="term" value="F:very-long-chain 3-ketoacyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="PTHR11157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="295" mass="33676" checksum="475A5BE579E0E839" modified="2011-10-19" version="1">MYASLMDSYLSYIGRFNGSGLTEWMANNSMIPFAAAALYLILVFYVPRYVMADRLPFNLKVPNIVWNLLLTLYSMLGAYYTVPGLVRGFNSPVALSAEMNQTTVTNGSSLAAAGGFYTTTCALDRKYYFDGDVGFWVALFSLSKLPEMIDTVFLILQKKPVIFLHWYHHLTVMLFSWFAYIDQICSGIWFSSMNYSVHSVMYLYYFMCACGYRRLVRPFAPIITSMQILQMVVGTIIVGYTYIVKHFMGQQCVVSNFSLQTGLAMYVSYLLLFSRLFYRSYIGSPKVPTEAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE5</accession>
    <name>F9WGE5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_01550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01550"/>
    <dbReference type="OMA" id="QHEEPRK"/>
    <dbReference type="OrthoDB" id="1682092at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389111" evidence="5">
        <location>
            <begin position="19"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="345" mass="37861" checksum="9BCBC143315170AD" modified="2011-10-19" version="1">MWRRVLLALVFVGKGTIAAEGKGVNEDVFKKLCNITKGVMGLMGKDGEHKGSLQKALYGEKKEDPFEGDGTFTGGCIELGMHSRSQYCSHIQPGRGSTRNGHGCFGDSLVGTFLCLCTKGGNGEKDLCGLNNVGDGAGWISNNGNEQTLFQKVWEEVKTKCFKNNEGTVNQEELNVTVEKIKEEALKKKINGGNKGYYLGGDKTTGQCSGVNPGEACVTYPAKSDKVNEPDIPWADKILTALQTLKTQQQTTLQNSATTSEKHQDHEDPSVEVSEEEGEEEEDEASAQKHDPQSTSKPSRQKRKRRSTNNQPAEQHEEPRKVILHKDDGSLLPQPFWLLSAVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGK2</accession>
    <name>F9WGK2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002281">
        <property type="protein sequence ID" value="CCD16439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15910" checksum="3F0EAC0EB92088D8" modified="2011-10-19" version="1">MGMLENPHEWHEDGITHKLVKLVRYEVKGKFECRNRVTSVYVLKELARKLRQAHLRRSLIYYILCGALEKCADLFEIARLRAFIDKSTMDKVVRHLMYLPRNKERKRESVLMQRNACPRPFPTSLPTVQNKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH15</accession>
    <name>F9WH15_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002359">
        <property type="protein sequence ID" value="CCD16604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15140"/>
    <dbReference type="OrthoDB" id="1679905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="327" mass="37129" checksum="77C709A866524A7C" modified="2011-10-19" version="1">MNKAHGSFLGPTTGQEDNELVRRDWDTRPHQAMTLSPNPTYTMTTSVLDVLLDGLRDTDNLNLLHFLEPWYEELPLHLLRFTVGDFMRNPERCIPEDRLRQEIRDKLDRMLRDLYKELLDQFSALHDASIVSLEDWAQRGSSCSLTVHELARGFLDKALKKVQETHTQAEAPVQVEKPVQRKPRGPRQGPVFLPSSSPSTSVSSCHRRESSPSSDVEFLVEFPSLKKEEVSSHGTQTKKRKRRASPHRESNEVNLQPKPQEVSSSGTQPAPRRKRPASPSMESLREAIQPMPQEATSSGAPPTRQQSQESYSDVEFFGSNPPPSRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH56</accession>
    <name>F9WH56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 597</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_15530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002378">
        <property type="protein sequence ID" value="CCD16645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15530"/>
    <dbReference type="OMA" id="SLFGMNC"/>
    <dbReference type="OrthoDB" id="794536at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015693">
        <property type="term" value="P:magnesium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="43142" checksum="5177DB36D7EDD723" modified="2011-10-19" version="1">MVLCEPHGIASHPASPVMHDGCCCVVIHRAAGGAGLKADTFASAAEALAFVRASEGCLWVDMQRCSEEDHRQALQLLFPHMQPSHVEAMLASDMYDVVELQPVGDEYVVGCLACSPSHGGPFPAAAATTAAVQAGVDCEEEVLCSFACSERVLLTLHDSLFSGLAELFRYMLNNRRHSVSNTPFVLCALVCHVCEAGLPDPTPLISEVDCIDEIMLLVAPGKRDQTDMLRRVAVLRRRLCSLNRRLNEKGKLLIEMAGPAMRTTFVSRDLRVAEVYRSALEELSQVLSHFECAHDTLNHANLNFMYAVTMRMSQASAGCDYQVMMINKIATICLPAILLASLFGMNCKVPWVADDCDSLLPFWIVVATIVLWMVVLLFKPIRDLLRSEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA7</accession>
    <name>F9WHA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002405">
        <property type="protein sequence ID" value="CCD16697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15919" checksum="B6A9D2C66B9AF397" modified="2011-10-19" version="1">MIFGWECYYTKAHHHTTPAEVSVRNKLKNRRKKVRKKNKQTNKGGKIHSNGMGESELKPQTRQLLRGTKNIKDKVTPIRQVEETQAATLHRKFLKLTKRREKKRSLHTPHKRQGTSVYSKLIPRNKHTGMIERCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHE9</accession>
    <name>F9WHE9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_16450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002421">
        <property type="protein sequence ID" value="CCD16742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16450"/>
    <dbReference type="OMA" id="ATHIAVW"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="854"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="899"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1119"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1123"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1247" mass="136776" checksum="DBFB907BD0599A49" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHF6</accession>
    <name>F9WHF6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 641</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002427">
        <property type="protein sequence ID" value="CCD16749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16520"/>
    <dbReference type="OMA" id="SANEQHI"/>
    <dbReference type="OrthoDB" id="603679at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="15"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="110"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="372"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="473" mass="52671" checksum="83B198F9314D0124" modified="2011-10-19" version="1">MEQLAEDQHREEGTTVLRLHGLPYSIEEDKIRDFFSDFNLADEDAIVFFVEGLHRGTGFIRLRNAGDAPLVIRQLNRRHIDESRYIEISYSSEEELQRAIGQQEQSSKALVLRLRGLPFLSTADDVKAFIESMDGVLRIDMCRDMDGRCAGDAFIELASEEGVARIKTLHKKMMGARYIEVLPSTLYDREAILRASSFRGRRGRHVTRGGAICVTEGDTSQPSHGSMVFQRFIDPIFSSNCGGYIQPVNFDGHKPMQYQYQHGYSSTSHHHSQHLQHHSMHPQPTNLQPYGSNNLALWGRGVGMRGGRFPSAPQQYRQFHDASRAIGGSGIAGEGPAGHSSAPYPTGYSGQPFLSVFHGQSPLVVARPPSAYVVRIRGAPFSATEEAIAEFFSGVRIPTQGVHMVYNEQNRLTGEAFVEVESKDDVLLALRKNGGMMGTRYIEVFESSPAAMQRLGTPPIGMMPYPVVPHMLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHK4</accession>
    <name>F9WHK4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 661</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002449">
        <property type="protein sequence ID" value="CCD16797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16970"/>
    <dbReference type="OMA" id="QDANTLH"/>
    <dbReference type="OrthoDB" id="919312at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="323" mass="36005" checksum="6E538F296A21A5B3" modified="2011-10-19" version="1">MSFRYTNSLIGVLKHRMLLECSYREIATRTFIGYCRGVEVVCSGYGSVLKVRLTEKEMWEPFYRNSAVYSNSEPLADKAEGESETASPMTGAASTGPLDLERLSESVRAALWDATRKIRSAKEAALHRSLSHNPQLQATAELKHWYEEDANTLRPLAFEALKHEAATPWMRLIQFGKLKEAASLLKNQRQGGASSSSQGVVNNGEKQQLQSTEGADVHAPLKDTLTVADLHPSTIPIGSVHPLFTPALIQMEDSQTGAVNDDAVRRAQLWELSRDEQYFWERVELIRKGQIASIGSVHKRGYADEALSAKDNAEEKVQLRFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHT3</accession>
    <name>F9WHT3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_17620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002484">
        <property type="protein sequence ID" value="CCD16878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17620"/>
    <dbReference type="OMA" id="ESFTWCT"/>
    <dbReference type="OrthoDB" id="34077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="PTHR16453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zinc_ribbon_16" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1236" mass="133319" checksum="645FCA71A44670A7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI51</accession>
    <name>F9WI51_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 732</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002528">
        <property type="protein sequence ID" value="CCD16996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18650"/>
    <dbReference type="OrthoDB" id="1658205at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="625" mass="67304" checksum="53015A50C3637B94" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WID3</accession>
    <name>F9WID3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VSG_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002569">
        <property type="protein sequence ID" value="CCD17080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389170" description="VSG_B domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16701" checksum="50B87CCDDED2A09A" modified="2011-10-19" version="1" fragment="single">MVFSMNVMAFVVIMGRVASGQVEVAKDDNIEPFSLLCRIYNVAKNPPINHVDLQEADKIVEEIDALNRSLLEEKRPHEDDDVGNHSEVQVKPTHNAGSSTRPTQPQSVTQKAHKIPEDIKKMNGSQKLERQRLSSTKSSFGMGENKMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIN4</accession>
    <name>F9WIN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002620">
        <property type="protein sequence ID" value="CCD17182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02240"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17881" checksum="481F67BD522FC41A" modified="2011-10-19" version="1">MREKHPDHDESLRPQPRAKPKRKAVRSEAQAQDEGSRSTELAGGGDGEGERPRKRPRMGRHKESEEGRNHVCHWSSSAYKQRYSLVWHTRTHHDHATTGKRKKRDGKVAVTPLPAQSPQCPYCPKKCALKMHLTIHLQAKHGQPKKRGRTQPSEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ26</accession>
    <name>F9WJ26_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002673">
        <property type="protein sequence ID" value="CCD17327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21550"/>
    <dbReference type="OMA" id="ANELRMM"/>
    <dbReference type="OrthoDB" id="1494426at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="452" mass="48235" checksum="406F295EB7F75356" modified="2011-10-19" version="1">MLSASQICPSGTSSINSLHTLVAQCQGDRSCFLCESQGGGASESTAAPSTSGGAATLAPQVPLCQSHSTRCVERSRCNEGRAASPTSQASYHSFLGYLTKSALNLTESAAEEGGSRVNGMGDEVGASSNGPGTADAQIDSPSSRLLLATSVRFLAGEMSTLYGKLSFALEDDEGVIFGEAEKAEITDILHRMGETVAKMCEAAQGTHEDLNAYNTMSDIVLSRIQRHEKHVKQLTEKIEMCVDTQREALAAASRQLKNERAAIKTVLLRSGCQHGGSSPGHWQSVQPTVTSPSEAAAVGDVSHHVDSTCTPELAITPAEKKMEDNCEEVGSPLNTFLPPACWDSSAGCTSLENLLELPVPYEGPSDQVCVCSTIAQVPLHELANNLLRSRRQLSLVSQLSRRCPNAGELKAALLEKEMGDVLNVFKALEHRYCSRKERFVSRCFIESLSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ37</accession>
    <name>F9WJ37_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 867</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002678">
        <property type="protein sequence ID" value="CCD17338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21640"/>
    <dbReference type="OrthoDB" id="1716681at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17613" checksum="B2A8B752302BD26C" modified="2011-10-19" version="1">MSSVPGDSWLIFLGKRVMGNGGPPGTLARSLRQIGGSLEHRLSCTGLRGPLQHSIPNAPRFCATVAPLLFLRSCSGFKHTQNTLNPRRHEPVYLGHLFGFTQSLSLVDDGAFRHLPQSFPRTSNGVKITAQGRGKKCHSVLQKKKKSDRHWLLGLSLSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJC9</accession>
    <name>F9WJC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 897</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_22520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002711">
        <property type="protein sequence ID" value="CCD17433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22520"/>
    <dbReference type="OMA" id="NIPWPTH"/>
    <dbReference type="OrthoDB" id="1484694at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="134"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="303"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="528"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="693" mass="75015" checksum="365A8DDC117E8DF0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP8</accession>
    <name>F9WJP8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 935</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002752">
        <property type="protein sequence ID" value="CCD17555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23690"/>
    <dbReference type="OMA" id="KRVMWDE"/>
    <dbReference type="OrthoDB" id="1449037at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043666">
        <property type="term" value="P:regulation of phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PTHR12398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18784" checksum="F57C9A5BC4FC5CB0" modified="2011-10-19" version="1">MPARKRVMWDEKNLEDNEEYRRAHPVTMHITEPKTPFEYGREYEEDFEDAMDRNSDVDTSASTSWDPEVNKLARQVREEFRKEVAEVIAPVSSTGRPMLSLEVVTGEALEKQREAEFKIMRKAVYADEGRRVKALLGKCNFDDEEEEENDAQGDKVHGEQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX9</accession>
    <name>F9WJX9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_24450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002786">
        <property type="protein sequence ID" value="CCD17639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1215336at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="PTHR12893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15250" checksum="F8F9F34E37B975FC" modified="2011-10-19" version="1">MGQGQSDADSQLRGIRGLQIVRVLLNSPAHIAGLVPFFDLITAVNGVMLQEGADAIESFKQHVAAQPSQPMHFTVYNLHVRAYRDVVCATSRSWGGGGLLGCSVEWCSAEDFTDRIWHIVEVTPGARLTDVEISKKAGNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJZ4</accession>
    <name>F9WJZ4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TCIL3000_0_24590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL3000</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="CAEQ01002793">
        <property type="protein sequence ID" value="CCD17655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24590"/>
    <dbReference type="OMA" id="WAMAERM"/>
    <dbReference type="OrthoDB" id="1310134at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="PTHR10942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD17655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="298" mass="33677" checksum="C32CF7B78A9060EF" modified="2011-10-19" version="1">MISTKVHRGKNSTFVITPKVVEVARKYYACKNMDGMQLEDGGNDDVRDSHWKRLFVKDDLMAAVVGASYYSALTLAFFHDTGFYRVKWAMAERMRWGNGTGCGLMNGKCMKNNITMFLDMFCNESVSTKLHCTYERQAIGRCALNTYGAPLDPDKQYFTRSWIGGNQDNLMDYCPIVEPYKDSYCEDGRQQLLPGSRVGPNSRCVKGDRLVAFSREVGDVCAEVYCGRDAVSIRYSGDDSWHVCPEGEYITPTKTFSSGRIMCPKREEVCYNTDMSPPFDPHASVALLFLLTSSRRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W376</accession>
    <name>F9W376_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1013</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000366">
        <property type="protein sequence ID" value="CCD11584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25550"/>
    <dbReference type="OMA" id="DQQSKDF"/>
    <dbReference type="OrthoDB" id="1199986at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="473"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="539" mass="59733" checksum="4E5A61A1F1E42B2C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3C8</accession>
    <name>F9W3C8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1038</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000394">
        <property type="protein sequence ID" value="CCD11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26040"/>
    <dbReference type="OrthoDB" id="1667067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="44948" checksum="2B397E7F866108B9" modified="2011-10-19" version="1">MPQGRGKRKATGEANHSRKRQRGPSPTLLDPSVEDTRPPRRIPRLVEDSPSSLLEPAVVASPHGNTQHVVEDSPASSLDTEVVVMSPPRPPTPPTPPFSIPRKSFLLWTMQSDLGVVLMELSGDPRRLNLYDFFKPAYPHIQPPLRPLTLADFLGSPKACHVAPYPLEEVLQSVPQLRKAMREKMLLRTWQLSSRNVLTLEDWARRGTYELVEPLPRMLLDEAVWKARPQPWPSPAGVRTATPPSSGRNPCVLHLPPRRPPKAWTVVSPIEDVLREGCDTWADVPLAEFLLEEYGFPVRDSARPRGSLYDFLENPTQHLRDEEAREQLLQKMQARLEDLRTRFRGDAEFLRLRGLTILGRWPRTAPFRDVLTWATKRILAVAWESCRRPAVPNLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3H1</accession>
    <name>F9W3H1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000410">
        <property type="protein sequence ID" value="CCD11689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26440"/>
    <dbReference type="OrthoDB" id="792460at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="353" mass="38363" checksum="6CF45715696C43FF" modified="2011-10-19" version="1">MISENEEEEKMEVKMENEGKKDAQHFPSAAACDITKASVSTSLTAARGKKQQTLAGTSLERTKRARNTGAEAKAPQDEKGSRTKQKKVKKESSATTSLMKLAKASKKAAGDKATAAAASTRSSEGGNAVRGILDDDEESHDGSSTKSGSQDICGPQREDFMDDIPPVLEAAITTTANDDIILCDDAPPMVFCAPEPPTSAQKKDAQRPESVTSSATSAAYPKLTEFFHPKVIAFQKQYVRELVTDTIFEAGEYISKDVVMYRHLSSNAMLSAEDYHRMSSELLQSLNREKQNPANNSDDKKADEDTEPLPSSPQLMIQRRKSAKTETASNAPPRTLMSYFKTGVVRDAQQANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P7</accession>
    <name>F9W3P7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_02950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000449">
        <property type="protein sequence ID" value="CCD11770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02950"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="288077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="HSPA5-like_NBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394540" evidence="7">
        <location>
            <begin position="23"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="653" mass="71139" checksum="D9EB699F8BD1D481" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3V4</accession>
    <name>F9W3V4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000479">
        <property type="protein sequence ID" value="CCD11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27730"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="348"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="534" mass="58290" checksum="2D797681D45167EB" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W460</accession>
    <name>F9W460_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000518">
        <property type="protein sequence ID" value="CCD11948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14792" checksum="911DC5E14C6AE985" modified="2011-10-19" version="1">MPQFAGVVGTLSWCDLVLRHMGLQAHADLLMCGSLHLGGFVRPMVWHEFCPTLGVCVLLGVGCVTCSSFTSGKSLCMCMPFLFLHIIVTRCAIHERDRWMRVAWSTVDCEKWVKASYDSYKRWLRASFTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R4</accession>
    <name>F9W4R4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000593">
        <property type="protein sequence ID" value="CCD12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30720"/>
    <dbReference type="OrthoDB" id="433108at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="302" mass="33710" checksum="0F92EE9F5ABF5EFB" modified="2011-10-19" version="1">MTFKNTETKCTLTFEDIILENRKRMKLMGITASNGSMCRLLMQMVSSVGELSNLAEQSDGAVSLSQFEHQEMQTLIGRISVCLFSIADVCDINIGKTVMDVIDDQIKRTNASTSCIRAAPKRSAPLPMAVSTAGTGTMSKGGVEKFFLSPSSNRGFFLQLDTLVTQSREDFEKADLRWVAPLPNGTIDELIDNGSEIRVRYEDIPKYMEMVQRYRSARTDEVTPFKYPSKQMSDRPDKRCKTAPLAIDPSSSKCDDHESFFSPPTADYVPLKTNATYDTNPDHFSTPRRNTASLPTKLLMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4T1</accession>
    <name>F9W4T1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1225</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000602">
        <property type="protein sequence ID" value="CCD12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30850"/>
    <dbReference type="OMA" id="WEENKST"/>
    <dbReference type="OrthoDB" id="1654515at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="795" mass="89537" checksum="B8D2BF5EC3E09156" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4X0</accession>
    <name>F9W4X0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000625">
        <property type="protein sequence ID" value="CCD12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31210"/>
    <dbReference type="OrthoDB" id="776571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="75"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="195" mass="21484" checksum="1D1AE4C4B7580B90" modified="2011-10-19" version="1">MQLPFHPSNTHGWLHIYAQGLRDVGWEGVFDAFNLPQLKTTRDTNGGVNRNGTAHMTNGEGQGWSVNETGIAVPSLYALLGVPPTVSQADLARRFKQLSLQFHPDRAAYRSGDDELAVQQMYQKIVEAYEVLSNPEHRIAYDTRCGVNFSSRVAALRQALAQNETTPAPHCPGGFGAVKSPQATDEEDDDEEYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W519</accession>
    <name>F9W519_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1264</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000645">
        <property type="protein sequence ID" value="CCD12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31660"/>
    <dbReference type="OrthoDB" id="1711802at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19068" checksum="51303B51149779AE" modified="2011-10-19" version="1">MTRGVRLLMNEGVEAKIFLYQALDLGNDRARFNEHGILTKHECGWHPSGRSPYGSHIQPGRAVSWTASWALYCARVFHGGETRKRCACWEFKEMAQVGTAGLSIRTCFGKYRRRTGQLHTNKHYRKHFRTLGKLTKFCGRDKGSSSTKEWQRLLFRGKPSYERTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W536</accession>
    <name>F9W536_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000652">
        <property type="protein sequence ID" value="CCD12283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="AMSEMHA"/>
    <dbReference type="OrthoDB" id="1653811at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="414"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="705"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1273"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1483" mass="170519" checksum="BBC9D15D91B2CC8D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W557</accession>
    <name>F9W557_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000662">
        <property type="protein sequence ID" value="CCD12304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1579717at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13837" checksum="F229E1EB6D3FEB78" modified="2011-10-19" version="1">MRRGMDVWGRRNFSADVSQCNLGTTASILRNLSGFAEQSHLEAREENVPFLFESLQLTKSSAVQHTRTLSLPTVRGTPAQASLVVLEQGAVNEPMKQARSTENWKLALMSNTPSFKCDRVALCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="11" xmlns="http://uniprot.org/uniprot">
    <accession>F9W577</accession>
    <name>F9W577_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1285</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000669">
        <property type="protein sequence ID" value="CCD12325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1658321at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="596" mass="68513" checksum="CE72F0F7FFBEBD53" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D3</accession>
    <name>F9W5D3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1314</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000701">
        <property type="protein sequence ID" value="CCD12384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32670"/>
    <dbReference type="OrthoDB" id="1715962at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18030" checksum="EAEE96B563687176" modified="2011-10-19" version="1">MAMKHPAVILVSNVPHGAPVSRLHPFQGEECAPSVFFHCCGCSSLAPFPLNRSKKQIIPVSSKKRLTPLRMSFQHFRAPPIGVKVTNRELGEEVSKLQGGLVPHGCVVGKWKPVRTTERFLNKYQLGRATARGARNITRSILGVELSQSANTNIFGVEAFTLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H5</accession>
    <name>F9W5H5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000714">
        <property type="protein sequence ID" value="CCD12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33070"/>
    <dbReference type="OMA" id="SAEAHLC"/>
    <dbReference type="OrthoDB" id="886530at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SSF82199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="5"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36713" checksum="C682E83228DA24F9" modified="2011-10-19" version="1">MTLLNAVGIRSAPLAQARRGSDGVRGVFAKRYFKRGDLLLSVPLHSCYFPHASPVPRKLRRWNRSTLIPEVPLWLWRFSPDIPEDRVTLTASVSTEESKVVTVSLSPVEAALAVSIAVRHFWRNVICLKDSVGSGRAVLGPPADRRADLYMRSLPLKEYLSYGLEAPYVSGAEFEGHVHSNLEQIAWNLRDCLLSYASQQEYSLYDAYASELDVALLASIYVVRARVMRMAVIRGDNPKTDGLTSVIAPFVDCLNHSLHETTCTACTSLPNRAVIVRAARDINVGEELTVDYRGFSLSRVGARAEIDPSNALGEDEDMWESRYLFPSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X0</accession>
    <name>F9W5X0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1394</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000790">
        <property type="protein sequence ID" value="CCD12573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34400"/>
    <dbReference type="OrthoDB" id="4577at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="626" mass="69577" checksum="34DDC3476BE4D534" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W664</accession>
    <name>F9W664_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000827">
        <property type="protein sequence ID" value="CCD12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="13405" checksum="825D1034583B72EF" modified="2011-10-19" version="1">MQQSDRSQDVSTELKQPSRNKCLVSGKEYHYKRLIRHMYEKHPDHGGSQWPTPLSQPPHTKKKSKMSKKRKQEGCAGSRGECGWEETEETSKNRPAHGSGERKILCVCKMRQRIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H4</accession>
    <name>F9W6H4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000872">
        <property type="protein sequence ID" value="CCD12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03630"/>
    <dbReference type="OMA" id="FCHAEDA"/>
    <dbReference type="OrthoDB" id="1234323at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="230" mass="26000" checksum="27FF187575B9C1D3" modified="2011-10-19" version="1">MFYPNSPQTSPPLTQLPYGQQYAMMQRQLQQPYNPFATEQHARLYPYNYQGPIQQDQGGFIAHQSAAAGPQYVQMRVTPVDQSIVGGYPNQMTNGCSSFNYNIHPQQQQQLRHQAMPIGSLPMQDERYRKQLIVNYLAPDVTSSDLHELFSRFGELDGARIIYDKQTNMSKGYGFVYFCHAEDAKEAMERMSGYEFHGKWLKVGYSTNPLNIVPSSALPYGHAGARTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R7</accession>
    <name>F9W6R7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_37130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000920">
        <property type="protein sequence ID" value="CCD12874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37130"/>
    <dbReference type="OrthoDB" id="1673685at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389868" evidence="6">
        <location>
            <begin position="26"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="51"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="161"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="39195" checksum="A8A71552229AAE89" modified="2011-10-19" version="1">MWKTMKVIVMILVMVLSTGLLEVGGYNDDIYNKLCTITKTASGLLKLEAGNEVLRGAIYGGGDSAKFGEGGKVTEGGRCVGLSLRTQLCTYFNRGNVWEGCYAESVLGALFCICAPGGRGGDVVDLCGAVVAEYNEAGWWGSWHSTGTREDLFKKVWGKAIKKCLEENENIQDVSEELKKLEDAMSSVREKIKGSRRSSDNLYFLGGSGTDRCDGDGKNVCAAYQAGPNRSASIPWMKKIEEAMEEMKIALARQVKEAKDVVIAPPAKGTEESSAAHRAAAESEHPTVLTKSTPHKNNLQNSDEEPGTEIALSSGNSEAPAKLKTKINHTASSVTDLSHLATNPDEDGSLLTKPLWLFLAARLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W775</accession>
    <name>F9W775_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000993">
        <property type="protein sequence ID" value="CCD13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38560"/>
    <dbReference type="OMA" id="MKWRRQY"/>
    <dbReference type="OrthoDB" id="681331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="599" mass="65225" checksum="64C0C99651C59178" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W788</accession>
    <name>F9W788_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000996">
        <property type="protein sequence ID" value="CCD13053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38690"/>
    <dbReference type="OrthoDB" id="1677462at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="300" mass="32975" checksum="B97BBCCC96484940" modified="2011-10-19" version="1">MWDAHCQLCCIPSYLIMALPLYISVGGLKRCSRPWDPISHRGPTSQFFPMHVPFHVCGGRSDVRIEVRVATIATLGNGSERCNGKGLQHSCGILRVAEWESRGESPMSSARARRLFANWKACLRAAGGGEAGRHGEGSRGFRDQTGDTHNRARECQACHGKGRKFMFQLRRNCCVRLNGVCVQAKNSLIHSICGVPVVEIAVAKDTPSALRNVSCCGGGGLGHPRSSKGRGRNARGLFACRVCKWLLQACASRERHRIGRRGTQAPRLRGLMSRNPNPYEINASWKVEQSKLPISLYVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W789</accession>
    <name>F9W789_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000996">
        <property type="protein sequence ID" value="CCD13054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38700"/>
    <dbReference type="OMA" id="NLENAWE"/>
    <dbReference type="OrthoDB" id="1655152at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="781" mass="88636" checksum="7E8609DD51436592" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7C0</accession>
    <name>F9W7C0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04120"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394593" evidence="5">
        <location>
            <begin position="26"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38817" checksum="B447C8EF121472EB" modified="2011-10-19" version="1">MMRMKIWMVMCFVVLCVVNTKEADASGNKDYNKDAHKALCDVLNAAVRKWEDVKHSESPMKEALRKIIFGKSGGNTDVPSGLQFPNDYNSANENERKNPNSRKNWCGACGGEEQKHYPGESAPHDLVCLCTPGEKGWPIKSQNGEKLCGKTRHTWGSDVSNKGWYTAWSDHDQEREYLNKTWSEIVTKCLNTEDRIDLDTALRTFMEEITRQNEHRLGEGTYDCDGKTGVGACVLYTPQCKKKTWWTELEKALQKEKDELEKQKLSGDKEQKLSSSKGLQTTPQKSTQNPQPTQRDSQSPQTDNSDDPPRAEQVISNINATIEEDSSTIILPFWLLLVFLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7E3</accession>
    <name>F9W7E3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01001012">
        <property type="protein sequence ID" value="CCD13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38940"/>
    <dbReference type="OMA" id="MIASAYH"/>
    <dbReference type="OrthoDB" id="1153545at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:cellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="PTHR19443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase_1" evidence="2">
        <location>
            <begin position="32"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="26082" checksum="7E6C74E7011B15C0" modified="2011-10-19" version="1">MSRRLNNILEHISIKEGDGEAVRSAKREVAMASLVNQFTLSVQSMRLIMSYLLHEMVEGLEGRESTLRMLPSYVYKADPRRATGVFYALDLGGTNFRVLRVQCKKGKVVDSMTSAYKIPDYALRGNATDLFDFIASNVKKTMKERAPEDLNRKVPLGFTFSFPTEQTKVNSGVLIRWTKGFTTKGVEGKDVIELLQTALRRVNVDVNVVALCNDTVGTLITKYFEDPRCKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7F5</accession>
    <name>F9W7F5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 160</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001021">
        <property type="protein sequence ID" value="CCD13121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04270"/>
    <dbReference type="OrthoDB" id="1669864at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="348" mass="37469" checksum="90814990D6554CC7" modified="2011-10-19" version="1" fragment="single">MSINKTTNDIEKSEYKWATGPFHAAPPLGKSSIPPGKMTDPSFLMSALFTSACAPSEDGLCTDYEDGCPENCHPCCDSIYRSINPFTLGYTTEGDPGCAHSDVTTERDKEGISTTPYLSQYLPTDRIPQGSVFDDKDKADRWLSNFGLQPPRRREWRDIVKDYLGKSTSAGTLPLGSHFEAATDAASTDTHDEICESVNGAGVIPPSPSLPCQNHTAGKDGALTDDNNEDVMVDLLLSMWRHGLTNSSCSTSVPNGETLEVSSGLGASGDQRCTSLHERDQTPPNYIVGEITSTRPRDGTSLPLRGDKHNASPPDKERPRSVMEESGNITAKPHASAAMNASASDPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q0</accession>
    <name>F9W7Q0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1639</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001063">
        <property type="protein sequence ID" value="CCD13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39920"/>
    <dbReference type="OrthoDB" id="1664333at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="444" mass="50351" checksum="920C0AC74658CD3A" modified="2011-10-19" version="1">MSRASSSTKRSRDGDRMESALVPSTPRPPAQHVDPTDSKSTARVMGEELGGYRRLYSMGQAVRVKHAAQLEAGTNDKRLTQLCVEYPDATEIIRTSDDGLPGRFLRLARDAPSMPLEMPDIPIGTTISQPGQPPRTIWDHDSRREIATKELEARMTNRRILHLHNNRERLRKFECIDTNIEFTQAMQVALRTFAGTLYVLEKFGPAITIEGMIKANGGSWHSHQKWLGRIDEEGNQIEPGKARGRYDHYRVAYQAACYWADHHERTIYALAGPLAKDVQTFSRHDYDEMMSAFVTFHIAIIAKVYAGRKINVTAIRQHYAEGIDDDIQQSIDEHISQYVERQYKRVAYNRRPLVPTLTRTASRTTFLGSGGRHRPLSLESRKGKSRKSRKSRNSRVNPYTSDAGNTPRSRTPSSTQSRQKKGRQHSNAKNQGKSRVRFTGAPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y9</accession>
    <name>F9W7Y9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_40780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001106">
        <property type="protein sequence ID" value="CCD13312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40780"/>
    <dbReference type="OrthoDB" id="1679308at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389978" evidence="6">
        <location>
            <begin position="27"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="47"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="269"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39348" checksum="0C8F78CD79B28D71" modified="2011-10-19" version="1">MIACMMMLKSLKVMMLLGVLMMGFKAQSEEMVETIKKDFELLCDFAGATMEFLSTVTGSPDDFHEDDEKKLSQTVHEIFFGEKGDAKGIWKLPTRFTEKKPNRSAVCGSTQPSNSEGMPSALDSMASTFLCLCTPTGKIRKGFCGVDVETSGNWPVNEISSANVDRVFVEVWGEGYDHRVMNKCGSSGKSEDFEDSMRSLTESMEKLESLLEEKSGTLGENSTTCQGVQCALVGKRPTWLKKLEEIKKIKKIVKPIKVINVPQQEISATAPKITTEPTSTSGPEHAPTSKNENIDHKVHEEPPKKEPRKASSPEPVTEPEKPAEMPPKLTEDLSVGGANETSENSIKGPKCLLPAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F0</accession>
    <name>F9W8F0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_42310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001165">
        <property type="protein sequence ID" value="CCD13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42310"/>
    <dbReference type="OMA" id="ELAMRRC"/>
    <dbReference type="OrthoDB" id="1626191at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="PTHR20922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20459" checksum="C15295D475EE0551" modified="2011-10-19" version="1">MFSRSGAVVTRGLCLSTFRTSLNTGTSALTPLRRRVRYCSSRTRASGSNLSALGTPTQGSTEKDIGELSKSLSEEDQKLILSALQNPDMQPSSKMGGPGVGTKNGDMVAVFTCGRCEYRMVKKFSKHAYTKGIVIIQCPSCEVRHLIADNLGWFVDESKNIEDILREKGESFVHLGCDYQVEPAANDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8K5</accession>
    <name>F9W8K5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001175">
        <property type="protein sequence ID" value="CCD13538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42830"/>
    <dbReference type="OrthoDB" id="1672923at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43747" checksum="739B88041F7DD4CB" modified="2011-10-19" version="1">MEIWEQRRIRNGIIVMVVSVVMECVSAGFTDYKEGHNFNGYEHDALCEVFKASADLWETSTTSKKKLGNDLENALRQALFGNTRTVHLGSITSTMPSFYRNLGHRGWRCGSCANGDAYSPGSSIPHDLMCLCAPGYYSEPFYAWWWDIWWHYEETKFLLCGKKREDMVSDQYQGWYVDKGTKVNKGLDKPWKTVVWGCFDNRNKGSGTGNLDLEEKVKKLKTTMQKFTTLLKLVGLHHKLGGTMNHTASDGRTEENIHVHYTDCTGRSEPWWKKLNQTLTKKKGSSSKAPHGVPSDPRGIKTTQDLHTNSTEDEFSLEEEEVEESPEQGSNSTQTKGHENSSDTTIDGTSSDPMGTWGDYNVHFQMLRSSTPVTPTSLWLLSTTILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L7</accession>
    <name>F9W8L7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001182">
        <property type="protein sequence ID" value="CCD13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13007" checksum="6EC44357DA343B9F" modified="2011-10-19" version="1">MGECLHSHRCGDAKYRLRVIFSVFFCSFRVRSLACPAVLMEHTHYLHPPFPRLPRAPCALSAVSVFSARGISAPLLLHGYATQISFAASTLHRRSSHFLLKKNSWCPSCLFRFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q8</accession>
    <name>F9W8Q8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1762</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_43330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001200">
        <property type="protein sequence ID" value="CCD13594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43330"/>
    <dbReference type="OMA" id="HEKAAMG"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="228"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="449" mass="49677" checksum="B6D4481CEC4D0E4C" modified="2011-10-19" version="1">MSHNGPGSPPGEGDGDNNAGSHSEITRSAAGVLSNEELESLEKLTEQELSKDVSKLLREIHQLEADERSKGALLRGMKEELDDSKKRLKDYKKLPYLVATVAEVFDLGPDDMEAEELNVGKKKSRRPHKSAIIKTSNRQTVFLPFVGLVDATKLTPQDLVGVNKDTYLVLDTLPPEYDSRVKAMEIEEKPKEEYTNVGGLGKQINEMMEAIVLPITQKDRYERIGIKPPKGVLLYGSPGTGKTMLARACAAATDACFLRLAGPQLVQMYIGEGARILRDAFALAKKKAPTIIFIDELDAIGSRRSDEGSKHGSREVQRTMLELLSLLDGFGSTDDVKVIAATNRIDVLDPALLRSGRIDRKIEFTLPDEEARSHILQIHSRRMILDKSVNFEEISRMTQDMNGAQLKAVCVEAGMLALRSERLYVAHEDFAEGVIAVQARKKSSLNYYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8U5</accession>
    <name>F9W8U5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001220">
        <property type="protein sequence ID" value="CCD13631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43690"/>
    <dbReference type="OMA" id="VMMERAV"/>
    <dbReference type="OrthoDB" id="1660174at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="521" mass="59038" checksum="8442F8F2B0029E57" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8X1</accession>
    <name>F9W8X1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 179</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_04550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001232">
        <property type="protein sequence ID" value="CCD13657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04550"/>
    <dbReference type="OMA" id="CEEAYLE"/>
    <dbReference type="OrthoDB" id="1323575at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:peptide alpha-N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017196">
        <property type="term" value="P:N-terminal peptidyl-methionine acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="PTHR45896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="77"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="258" mass="29811" checksum="EC7A463464F8C1EB" modified="2011-10-19" version="1">MTRKQAKALQDREMDVVLGKARAVTEPSLDERRKEMALLTQRLIRETAERDEQAAKVRIPLRDEQKAWQKVSDTKYIRYEQFDGDDEAMDFIVQLFARELTEPYSSFTYEYFVFGWPDLTIIAHGYEGEVPPDDSVKGIRVGAVVSRVSRKRVDGPLRGYVAMFAVIKEFRGFRLGSRLVALTIDLMREKGCEEAYLETPTSNERALSLYLALGFVKYKFLPRYYLDHSDAIRLKLWLKDPFTTTQEQETKVEAASGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W913</accession>
    <name>F9W913_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_04590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04590"/>
    <dbReference type="OrthoDB" id="1698060at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="23801" checksum="E0E0CB7EE008F6A5" modified="2011-10-19" version="1">MIATLGNGSECCNGKGLQHSCRILRVAEWESRGESPMSSARAWRLFANWEACLRAAGGGQAGRHGEGSRGFRDQTGETHNHARECRTCHGKGRKFMFQLRRSCCVRLNGVCVQAKNSLIHSICGVPVVEIAVAKDTPRTLRNVSCGDGGGLGHPRSSKGRGPNARGLFACRVCKRLLKACASRERHRIGRHGGATLPEDPPCETNHVERPPKHRVYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W966</accession>
    <name>F9W966_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1828</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_44630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001273">
        <property type="protein sequence ID" value="CCD13756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44630"/>
    <dbReference type="OrthoDB" id="1652048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="2" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="459" mass="51201" checksum="10450B484D32A555" modified="2011-10-19" version="1">MRKIIEDAQPDVVGIQCNYTVQWGNARALADLVKSIDPNLLLVTGGAHSSGDWQNALLDSPFDFTLINEADRAFTLLLDAVTHEGGNVDAVPGIAYRSYSGQLVRPTRKSSYLSIVPARQDLDERLGVMPLPDFSFLNMNNYLQPYHSSGARVRKTGAWAQIFSTIGCNVNCNFCYIPKINGPWRALGLDWFDLHLADLVKQGVTEVLIEDDHLMHDPLYAMEVGKLLKKHHLPWVEEGGLSLFNLVLLHKGERFLAELDEQELKSPHYRNVIAAIRGGLTAKTFIRSIADNGCYNIYLAVESANEESLVNSNKSRFNAIQQATFEIIQMFTECGIQVTGGFMLGFVNPPASAAEQPFIESLGQIGNTIDYAVSLMGAGMAYANPFIVTPIPGTEMWAYQQQYVVRHYDNGWSHEKATMATEQWSAEDIEKARMELLVRANGADRVREMVRRGTWPVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W977</accession>
    <name>F9W977_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_04800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001277">
        <property type="protein sequence ID" value="CCD13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04800"/>
    <dbReference type="OMA" id="HRSYISE"/>
    <dbReference type="OrthoDB" id="559299at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="PTHR22589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carn_acyltransf" evidence="4">
        <location>
            <begin position="59"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="29675" checksum="9F49C10934D5EA6D" modified="2011-10-19" version="1" fragment="single">MAMRCSFVSQSAAIPSNVGEWRLQEPLVRRLTTGVCTDFKALHPCVIPTRHLQRSLFRLPVPQLKTTCRHYLDAVRPLVSPKQYSATMKIVEGFQAREGVLLQRELQRTDSVNKHTSYICADWSDRYLMDRTPLPINRNFCFITKRDVDKPDMLTRAAFWITSSVNFQRMYLNDTLRPDFMYVGSENHYCRKDWFHRTVALTPEYFSAKAAAIGSGFHAIPLDMSRYDYLMCSTRVPGVLRDEIRAFRTATHIIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K3</accession>
    <name>F9W9K3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45950"/>
    <dbReference type="OrthoDB" id="1530619at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="303" mass="34209" checksum="A0F3D8146074E5F7" modified="2011-10-19" version="1">MLTSLDNTTTDAIQNFHDALQRSQEALRQEEARLAQLSQAAQQQHDANSTRREFIRTQQQPRLDALHREIARVRSLLEQQRCEVRQQQSQLEAIRRPRRDGEAKSSELRRKVEGQQWEYSRRATAVQSVLLQWWCPQNSLENLTAAASRRGAEVEALRRSGAALQAKLEELVAANCQHDSTDDNMSNLAGNGETCDGNENDNTTTAEECCNNGVSAESLQQQLKDHHEEREAFLRSSAEVISTRRRESQRLKAELQRLCTAVEEADAARQESQQRLRAALNEHGDACVKCCRCGVDVVGSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P0</accession>
    <name>F9W9P0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001334">
        <property type="protein sequence ID" value="CCD13944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46290"/>
    <dbReference type="OrthoDB" id="1707863at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21130" checksum="B6C7BF5F29125751" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEANVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPYQEVVLVEAAPAFIQVPYPAVGYLVPIPVSPGDWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Y3</accession>
    <name>F9W9Y3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001364">
        <property type="protein sequence ID" value="CCD14038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47180"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="325" mass="37057" checksum="E569A25E137EA7E2" modified="2011-10-19" version="1">MQLTQAFSDELDCSDLLAALLSEGMGTHVVGRSVESSVLEALRRKQRRPVETAYMRYMRERRERAALEQMTTEGKQLAVDQVIGDKSSSGEVRSTLFPTIPESQRPQHKIPIRKPTAFAGGLPKLRRSVLPTPRLNSAYLDGVDDFDLVINMRTPVPIHPIPPFFPGRTSTQRLPLLPRPRPRLAPLPMSVRRLVLTDYYGGNPAAKVREHSMRRMTLFFRGVRVPRPIIGRAPLAPLSSTAGGTYHQLAALRVLFQRRRRLHRRLRRQLRETEEEALLNTPRYVPVKLFSLTAKTSLTEAMRECLMRYINDKAYLDVLHGRIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA04</accession>
    <name>F9WA04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001368">
        <property type="protein sequence ID" value="CCD14059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="PRYEAIC"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="760" mass="85757" checksum="F11E1F205E463920" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA50</accession>
    <name>F9WA50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_47700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001390">
        <property type="protein sequence ID" value="CCD14106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="TIWALNI"/>
    <dbReference type="OrthoDB" id="266497at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032508">
        <property type="term" value="P:DNA duplex unwinding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="3">
        <location>
            <begin position="310"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="522" mass="56829" checksum="7775808B700AC01A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC8</accession>
    <name>F9WAC8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001414">
        <property type="protein sequence ID" value="CCD14189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48370"/>
    <dbReference type="OrthoDB" id="1706857at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="23194" checksum="8AE5C7950E71C8F7" modified="2011-10-19" version="1">MITLFLLPFQKALIQIPMSFFTITSPRTIPWSMERDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPCQEVVVVEAVPAFIQVPYSTVGYLVQMPISPRSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD2</accession>
    <name>F9WAD2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001415">
        <property type="protein sequence ID" value="CCD14193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48410"/>
    <dbReference type="OMA" id="FAFTGHQ"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="90"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="499" mass="52782" checksum="EC9F37C3AD866DD0" modified="2011-10-19" version="1">MPLFPSFSHPFPQPQWRKAQHTQEGRKAMDPRVEPAADPEEGSLPTGAVTGTPGAQGEELKPGGGQHHGDAKEGGTRTLASCITTLIPPGGMVSTVFNLSSICIGAGILGLPAAANSGGLIMAFIYPLIIVLVSVQSLYCIAAQVEKHSLKSYEGMARVLLGPRAAYAAGMLRVLNSFGACVAFVISVADILVAILQNSDAPDFLKSVTGNRLLTLGVWLCCMLPLVIPRQVDSLRYISTVGIIFCFYLMGVIVVHSCTNGLPENIKKIHLSGGPSDDGIHLFGTGNKAIEAPGVFTFAFLCQAASIEVYSSMTQPSVTRFTLYSAYAMAMCFVLYVTTAFFGYLDFGSKVTGSVLPMYDPVGQPAIMIGYIGLVVKLCASYALLMFACRNGIYNVIGRNPDTVVSWEHCLVAVVLSTITLVCGLFIPNINTVFGFVGAVCGGFLAFIFPALFMMYGGGFTLQKVGPLCYTATYALLISGVVLSVFGTVATIYGVATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAK4</accession>
    <name>F9WAK4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 198</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_05260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family. HslU subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001443">
        <property type="protein sequence ID" value="CCD14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05260"/>
    <dbReference type="OMA" id="KYGMIKT"/>
    <dbReference type="OrthoDB" id="1040247at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004491">
        <property type="entry name" value="HslU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF3">
        <property type="entry name" value="PTHR48102:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00390">
        <property type="entry name" value="hslU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390057" evidence="5">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="100"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="ClpB_D2-small" evidence="7">
        <location>
            <begin position="370"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="478" mass="52826" checksum="3CE99435636AA4C8" modified="2011-10-19" version="1">MPIMRRTNSVSLCLTLAKSLGSAVRFNGGVAAAAVETPTSGTAESIAGKTLVRNMKPRELMRELDNYIIGQTDAKKAVAVALRNRWRRHQVDAAIREEISPKNILMIGPTGVGKTEIARRLAKLVDAPFIKVEATKFTEVGFHGRDVESIIEDLYKASLTQTKQNIMRRHEEAARQKAENRILRALAGVSDGFREHLRSGALDDIEVIVELQEKKEKPKNTGSSEGVFISLELPSSIGGQRPQTVKKVMKIKDALPAVLQEELDKIVDTEDVSAEALRACEEDGIVVIDEIDKIVTASGGYKGHQASAEGVQQDLLPLVEGTTVSTRGNVQIKTDKILFICSGAFHSVKPSDMLAELQGRLPIRVELKPLTKEDFHRIITEPKYNLIKQHVMMMKTEGVDLVFTDDALWEIASIAAHINSTVQNIGARRLITITEKVVEEISFDGPDRRGETFVIDAAYVKKSVESMMKKVDIKKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAL8</accession>
    <name>F9WAL8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001451">
        <property type="protein sequence ID" value="CCD14288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="14504" checksum="6F52CF33252E69FF" modified="2011-10-19" version="1">MNIERDHATSFSLNSQAHQCYSCKTRSSQACFNFDVPDYNCYFLYRATNHTVVFFSLSSFLDHTLQQIHMAGGLLLTGRRDIHFICFAMISICTLPGLFPRWNTSRRYPQENSSWRQYNTPRCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB03</accession>
    <name>F9WB03_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001511">
        <property type="protein sequence ID" value="CCD14430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50450"/>
    <dbReference type="OrthoDB" id="710473at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17406" checksum="0DF2ABCF1E5F53DB" modified="2011-10-19" version="1" fragment="single">MEGSGRCASPVGSPLIGGNRKSETLSGASLLSKDLRSEDIRRAKTLCLYGREFDDDIVEYVVTKLLPEAQGLIKIEITDTQISAKGMKTLTRAIWTNSPCEKLEELVFHNIHMHYEETTQLKEVIMKNRKHLRRLIIQNCHMNDSAAEPIVQAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBB6</accession>
    <name>F9WBB6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2087</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001560">
        <property type="protein sequence ID" value="CCD14547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51540"/>
    <dbReference type="OrthoDB" id="1706152at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19498" checksum="FCAB5477DD55E121" modified="2011-10-19" version="1">MISRGEWRDTCCNISHALNPSLGLGVPIIKLSSTLSTRLMRFLGKYETLCTPLNPPACCFGRPFRQSSGHKKINDSGDFLRHNSITSSLLEHCLRPRATAQIPKRHPNVGPRGACVAPWSKYRTSKQWPAGSSDGAYLSGCPKQAQPSTKQLCTVMLDRNTPKRAATISVDRLHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBG2</accession>
    <name>F9WBG2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001577">
        <property type="protein sequence ID" value="CCD14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="13908" checksum="BAB55EE0BFBC411F" modified="2011-10-19" version="1">MVMVGVMVMVKVGVMVMVKVGVIVMVKVGVMVMVGVRVMVMVGVKVKVRVKVRVKVKVRVGVRVKVGVMVMVKVGVRVGVRVMVMVRVKVGVMVMVRVGSGSGSGSGSGSRSGSRSGSGSRSRSRSGSGSRSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH0</accession>
    <name>F9WBH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52070"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16691" checksum="6B4AF579577B33CC" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTHAPCRRQKPQCGQQLLHAFGLHHVPRVLGCAWCRAMVGTLACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBY8</accession>
    <name>F9WBY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53620"/>
    <dbReference type="OrthoDB" id="1705296at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20374" checksum="338163CF22F1CA29" modified="2011-10-19" version="1">MRDYTGICCLLHSQPLCVVSKHCVTLVFTLHGPRLKNNTITTTIALYSIMTFQEPFRLRCIAGTISHGRLRLVNIYTNKYVRSLFFSWLITPLLLALNPDTPMYHKGPVLCLGINTPPALLPVRMDWCGQEARGCQRKYAALPALWGGGRCENAPPHVHALLDVKLNLLLISRDVERNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP6</accession>
    <name>F9WCP6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001749">
        <property type="protein sequence ID" value="CCD15041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56070"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="19175" checksum="0BDCFA994D22BFC6" modified="2011-10-19" version="1">MKARGAQFAEAADKMSPQQHATYSKLEKVRHMCDTIEVSVKPHEATVLQWAKEVYFNTTAPGLLKAETPEEERKVHTMRRVQRFNGYDYQAWKDGSVTLGVSSDAEALVCPLNGKREKVILCGGNLDSSFRVECVAVEAVLQRLLRTIKVNELRKMREWSLSRVRCKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS5</accession>
    <name>F9WCS5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2260</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001753">
        <property type="protein sequence ID" value="CCD15073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56370"/>
    <dbReference type="OMA" id="NGFMASA"/>
    <dbReference type="OrthoDB" id="1714279at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="20609" checksum="C780E977D59F8953" modified="2011-10-19" version="1">MMSYFEVWSQKRKAEDRVPITIALFVPSCCIIVMQTLFLSLPKAALPLTFPFFITAVANGFMASAIALVSRTIFARDPAKHYNFCFLGSVLSVIFLNRLLYGEWYTHQADGRGEDVCTDRVCVVMPLAFLLGLAAVAFLSSTYVHLQYRSVCNKALDEWRRIREEAQGPQEPPVVAPAAGQHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCW7</accession>
    <name>F9WCW7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2285</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001781">
        <property type="protein sequence ID" value="CCD15115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56750"/>
    <dbReference type="OMA" id="FPFFRTE"/>
    <dbReference type="OrthoDB" id="1409686at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23861" checksum="BDE4699D7D6B73D6" modified="2011-10-19" version="1">MFLLFPFPFFRTEKIRSPVRHIPRRAASGNNRATAEKRQKSKHKWDLKKCKRKKPKMGSVELNKNAHRLNRIFRKPKTMVKPRSWRPSEESAEERRLFSGVTLGRINAMIGGLSEDDRTRAAAEQDPPTVVQEELAKRAARFGLPAGVGAANAADPSKSTVVTPEMAAAMQRRMERFGQTNVEEILQKRMERFGDESLAMQRRQARFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDD1</accession>
    <name>F9WDD1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2353</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001857">
        <property type="protein sequence ID" value="CCD15284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58150"/>
    <dbReference type="OMA" id="KTYAKLN"/>
    <dbReference type="OrthoDB" id="877365at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36371" checksum="F64CE14EA88E4A8E" modified="2011-10-19" version="1">MWLFSRGSSAAGSDGSRSGIVQPLPNAADAQVVMEKQIKAEGHAQSALSTSLIDRSKMSQLAMSKGDGRVAFFDTESIDCILKRYEREMTLADMQIKRKQEESDKKLFNFYDYEKDQRYNQWLADQQRVRENLKLHWLDLAIDRPMLSLKYLARVGTTVGLFYGVGRTVFLYRTMDKMYAKLYGVSVANIALYEVSCSVIKGAIVSVAGSLGVVLGEAATNIVTTALTGDISVPERSWVNVWACGTSCGTFSGAMFAALHTSLLTTWGMAAAVAAFTTVGSLSGLGLGLYTYKPYAGAREKQINSPYWRPWYERRISDSGGSYMRGRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDD5</accession>
    <name>F9WDD5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="7">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_58190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001859">
        <property type="protein sequence ID" value="CCD15288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58190"/>
    <dbReference type="OMA" id="DVANAFF"/>
    <dbReference type="OrthoDB" id="498515at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-linked sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="PTHR22897"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="SSF69000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389007" description="Sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="310"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="447"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="522" mass="59009" checksum="6E59040BE9D3ABBB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ2</accession>
    <name>F9WDJ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001875">
        <property type="protein sequence ID" value="CCD15346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58750"/>
    <dbReference type="OrthoDB" id="1710734at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21410" checksum="244ADE39E91F1F6B" modified="2011-10-19" version="1">MQTHIITSPRTIPWSMEKDVVDVLLDGVTYADRINLYWFLRPVLAPLPVDLVIFTLRDFVRNPRHCIPESNVCDSLWQYLPYILWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDTPLEAIDEEIWSRCRRPPPPPYQPCQEVVLVEATPAFIQVPYSTVRYLVQLPVTPRAWPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDX7</accession>
    <name>F9WDX7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001928">
        <property type="protein sequence ID" value="CCD15482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60000"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29558" checksum="DD4E2C0BAE4AAFD4" modified="2011-10-19" version="1">MDSHSRQVGAVDCGDVGSLMRWVVPEPRVEATWTNFQGHNIIRRSQGTRVASWEEETSLPLQEVYVGTLSLEWVRRRMEDEALRLFDEVWNLMINTGRTSKRDRESHLRIATEDAHKMKQAGVIGHASDLPTKGWAIPSSVVEEKTAGRRCGFIAWPKAKNAKNDYEAEVPLGHISRYLSAVCNEAVALFDLEASFLQADMPRGIRAGFRCRTENGELVELKWLPVGYKGDTEIVHTITRALAGGCGGSHNGVRGSKPLENPHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE34</accession>
    <name>F9WE34_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leishmanolysin-like peptidase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MSP-B2</name>
        <name evidence="14" type="ORF">TCIL3000_0_06370</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.</text>
            <dbReference type="EC" id="3.4.24.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06370"/>
    <dbReference type="OMA" id="DSEEPRC"/>
    <dbReference type="OrthoDB" id="1310134at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001577">
        <property type="entry name" value="Peptidase_M8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10942">
        <property type="entry name" value="PTHR10942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01457">
        <property type="entry name" value="Peptidase_M8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00782">
        <property type="entry name" value="LSHMANOLYSIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023964229" description="Leishmanolysin-like peptidase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD15540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="540" mass="57859" checksum="0F2256A1B13ACFBA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE66</accession>
    <name>F9WE66_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_60580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60580"/>
    <dbReference type="OrthoDB" id="1695811at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="28849" checksum="503F39E872B332C8" modified="2011-10-19" version="1">MACGYSPSFFLLLLFPPPFCGFRKKEHTLKIRKRERRLMRFLSGTACTFVILLLCGPGMGNAFLPWRRSFVCMEGEKLLQNLEDQFSQRLQIYAETLNSTESLRDHCESLQKVLATPPEMRSETGGKSYTAFLRDQTLLEEFRNQLKRLMQDIKNQCGSWIGFYLANWRLPQRLDQKVADGQRLRQAFDDHLSRVQALWDQANITGCSPEEYERMVQAYQERQREQKRRRKAMDDDKETSQEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEB1</accession>
    <name>F9WEB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_61010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001967">
        <property type="protein sequence ID" value="CCD15618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61010"/>
    <dbReference type="OrthoDB" id="1663309at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394709" evidence="5">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="82"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="423" mass="46699" checksum="520E01087545EB8C" modified="2011-10-19" version="1">MAYMVNMILVAIVVCSIVKGTAAKGAQVQNNDNSEQFALLCRIYNVAKNPTIHHVDLQDPLKIVNEINAFNASFIDEKQFNETEDVVNSSDAQIKHTTTREAAVAQAILSRITKKAHKILVEIKRVNDTRYIEKVKAEFSQVIFGEGRNESDLCDGVLKGVGERGAACGISGLSHKGNYAGKNLVVDFFCLCAQRTKNGNNEGMDNVCGVQVGGKSKGDYQGWGDAAPLGSPSMWASIKKECSKLLHKHPESTEEGHEILKDFLKHLEMGGVYRWGSSGKDSGRKEGMLGTSVGTNEIGDEPGPVCNGKKGNNRDTHTSGICVYYGPNKWEENIDWLKKLKNALASLESVNHQTATIQRDIEKLHMLLHRAEQIYETTKVITEMQNPKGLTAFPNATPKRRTAYNAAWRHNQHAHFILLVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEG3</accession>
    <name>F9WEG3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 261</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002005">
        <property type="protein sequence ID" value="CCD15671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06890"/>
    <dbReference type="OrthoDB" id="1705837at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19490" checksum="F75964695215F0CB" modified="2011-10-19" version="1">MISRGEWRDSCCNISHALNPSLELGVPIPKLSSTLPTRLMRFLGKCETLCTPLNPPACCFGRPFRQSSGHKKINDSGDFLRHNSITSSLLEHCLRPRATAQIPKRHPNGGPRGACVPLWLNYRTSKQWPAGSSDGAYLSGCPKQAQPSTKQLCTVMLDRNTPKRAATTSVDRLHESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER3</accession>
    <name>F9WER3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_07900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002055">
        <property type="protein sequence ID" value="CCD15779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07900"/>
    <dbReference type="OMA" id="FTPDQAG"/>
    <dbReference type="OrthoDB" id="1092362at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394957" description="Ubiquitin-like modifier-activating enzyme 5" evidence="6">
        <location>
            <begin position="18"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="7">
        <location>
            <begin position="99"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="44942" checksum="9C377896AF789467" modified="2011-10-19" version="1">MPFRVLHFLGVFYFICSFYDKQYFAPVRNIFFLSLNIHTHPYLSTFSSFNCWGCLCFDCCKEGDRSTEKAGRTEAIIEMDQEKGRRQVLDATVRDDNPYSRLMALQRMGVVENYEMIRQKSVAIIGAGGVGSVVAEMLTRCGIAKILLFDYDKVELANMNRLFYRPEQQGMSKVEAARQTLEGINPDTKVVPYSFNITSTEHWQSFVDALTKDGGAQPGMPVDLLLCCVDNFQARLTVNYACLQFDIPWMESGVSENAVSGHIQLLLPGVTPCYECCPPLVVATGMPEAKREGVCAASLPTTMGIVAGFLAQNTLKYLLNFGKVSEYIGYDALRDYFPSVTIKANPDCRNATCVERQRQYAEKRLTMGEAAHPLHAAARLLQKGGAKERKTAKARAAASAAEGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WES8</accession>
    <name>F9WES8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002058">
        <property type="protein sequence ID" value="CCD15794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08050"/>
    <dbReference type="OMA" id="FTLCYQT"/>
    <dbReference type="OrthoDB" id="803097at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="PTHR14614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="35934" checksum="694E24792AC6F455" modified="2011-10-19" version="1">MSGGFHFKFSDDTAESTSVTTEATHSETQGTVEPVKSVPFLNAPVHLLTRQLLEEWCLLGQQNPQEQIELQCHKASGVPLLAHQRAPRVEELTVVGGREYRDIVPGKYYGGLKVWSCAPYLMEYMFDNRDMFRGLFRGTGEAVCDGTQGSVGNAFRYPIVIELGCGQGLPGVAALLIGARHVLFQDYNDEVLELCVKPNIGVNLRRHMEAAEACAEDDDMCPTIVQLVSGDWGDMHWDGVAGGSVAILGSDVTFDEEACRKLAQLLQRLLSSSSGMAWIASKQYYFGTSGGVLEFTQRCNECKLTVVEVSSSGAGGGMHRVILLVRYQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF25</accession>
    <name>F9WF25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 342</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002094">
        <property type="protein sequence ID" value="CCD15893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08870"/>
    <dbReference type="OMA" id="LHESCAD"/>
    <dbReference type="OrthoDB" id="1367024at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="491" mass="52559" checksum="43D262B146700938" modified="2011-10-19" version="1">MYAKGKQGLHNLDETLADIRRNARQEARFNQEELRRFMIREDVHLQNAQRQQQQQVRASAATATKSVTSSACCTSDTPKATLPPWCEGQFAEPITNGAAGVIVCSGVERDVAEDVMDRVSQAAKSLYPQLLSELDKCTASSQSRQRCGGQEEGEEADSEIEELHESCADTVVQWNSSGMPLLLRCVRPATPGNVSAPPPVTVRGSVTSTRGNASNDTGITPTTVFDEDVCVKLYEYDGLAGPRGPVLLSARDEGESCQSGSKAVIKGRLQERPKAQKPLISRNANKLRLHTVGTAVAKSSAISIANKIRREVLQRGSSCDEGKAGDVSNQRAVDPRVFFCGPQEEEVVYARVVEPLTAYFCDRCGTCVSRHMSTGLPDVCTTCGAALGDLPIFSRRTLSDVEREVSFVETNDSGCGLGSGCAERGTKGSVGTEMELAHSAACVATANRVGSPAGCCTMATQASAPSGLKPLPPTARGLYFLHLWDQVTSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF48</accession>
    <name>F9WF48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 350</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002104">
        <property type="protein sequence ID" value="CCD15916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09080"/>
    <dbReference type="OrthoDB" id="1717073at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="17950" checksum="24B843DF531A5F15" modified="2011-10-19" version="1">MPLARVLAHHPVLGKALLDGWCVAVGFSRFPSGSAAAVEVLRALSKSQGTEDGALLVLESVGDRSAPELREDVEKNDVTVFYPSTGQPGVRERNWSMFPAVQSCRRSFSASPPRPGSPTRALAGFLCSKSVHFGGHEYKTRESDGRYGKRAAWKPRTKEPSRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF73</accession>
    <name>F9WF73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 355</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002110">
        <property type="protein sequence ID" value="CCD15941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09270"/>
    <dbReference type="OMA" id="DERIEHT"/>
    <dbReference type="OrthoDB" id="1215445at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1346"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1203"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1351"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1451" mass="160551" checksum="69429AF0607ECEB0" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA2</accession>
    <name>F9WFA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="13784" checksum="9AB29FA4D2E456B4" modified="2011-10-19" version="1">MLGATKGGLWPWGQLRGNEMAHLNHVAFLFCWIVGGCLSFNTHAIYGGQGVGAGGGGAWRCCVSGRGLTSAVVVMVIHPNCLTVRMTRWRDVKALLTCTECDGGSWPGRANGIPLTAGVLPRVAGYWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFI4</accession>
    <name>F9WFI4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002148">
        <property type="protein sequence ID" value="CCD16056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10240"/>
    <dbReference type="OMA" id="VPCEELE"/>
    <dbReference type="OrthoDB" id="1453059at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="38600" checksum="FFB55DADDDA6994C" modified="2011-10-19" version="1">MQVSVLASSGVLSSCGRHGTSILVGQRSSYGSSENLERTVHTVLETVPCEELEVISEQMDCLEQILPCGIELLGLVQEGDEVQQTSKLRSFLTDRLKDNLIVLFVSSDRATKRCALLQTNEEVALEVLDTVIPFITLPCYLFSPLSTMPIILRRGGSDSGDGVLIDLTSTRLLQNTAIWRSEDINATQLGGRNDCRDLVCVNITFAPLYSCGADIYKWLLHFVQITGSQLHARVLRVQSLRSPLLTYQLIYSSTDTGGDNPSKKQLKQLGELMEDGSGEKLIPSQIVAGSKGFTAKVSLSSSRGDKTAMTTEDDIAHAGGPIAGKSDNFLSVHILIVAAGVMGLLACMLHVTGWQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP8</accession>
    <name>F9WFP8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 414</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002175">
        <property type="protein sequence ID" value="CCD16125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10760"/>
    <dbReference type="OrthoDB" id="1704727at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="20656" checksum="8FDC574B97280020" modified="2011-10-19" version="1">MVEEHPQQAIFSAAEGDHGAVFIKQMAGGGVQAPAPEPQQPSGFGNDQVGRQHARTAQHSVDARQQFTGGERLDQVIVGAHFQADDAIGFVIAGGQHQHRRGLVFAGANVAAEHQAIVAGHHDVQHDQVYRRGLEKRAHLAAIRNHGGPQAVLLQVVAYHLSNLTVIVHDEDVINVFHGPSLCQWELRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU3</accession>
    <name>F9WFU3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11230"/>
    <dbReference type="OrthoDB" id="1708248at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22385" checksum="43EDAEBEC64363DD" modified="2011-10-19" version="1">MAIQCHGEFLVSDELCLVHMLHHILPFHLLQAIMLSGPYTLNITRENLSLLLVLEPNMTLLAPASFPSCGVLFHFHYAFSPMSPCSLPSPLHRGVFFYSCDYLSSSHSNKSALKHRGVLSPNIIFSMNIEWDHATYHSRSTPSHTNATVVKHVHLKLVSISTCLTTVVIFSIMLQIIAWCFSPYHLSWITLYNKYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFV7</accession>
    <name>F9WFV7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11360"/>
    <dbReference type="OrthoDB" id="1697373at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395004" evidence="1">
        <location>
            <begin position="27"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="25259" checksum="F4CAA6E04CC562B5" modified="2011-10-19" version="1">MMADEARLGLQFLFVMLMLCSECTWGNNWQAFPTEVGESICSISRKMKDVSSWTIEHLRVLKERRDEYASKFLDWKLHFHGSPECGENDSILEGIRTVLERANEEIKTLPAKAICAGAPAAKSAGRLDEFITVFANARKTGSVFIKTDSETSNYCLGSGGEKAQRRDLFDCFPTGGKFEIGEANLAKIPESMTDLSDPNLIAVTENINHSSVVEHINRKYVIDDKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX4</accession>
    <name>F9WFX4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 432</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002194">
        <property type="protein sequence ID" value="CCD16204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11530"/>
    <dbReference type="OMA" id="HIKRQFI"/>
    <dbReference type="OrthoDB" id="1591742at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="22501" checksum="970A3E28C21B536A" modified="2011-10-19" version="1">MSSPNGGGSLPTSQFGSRGSSPEPPETATLSHIKRQFISSLVGSSAEKGVEARGLLTPPKSLRAEEKETRPSSSDSLSSRPSGGDMCDVDIPRTSDELVVFSNEQNHSGGSCEGSWNSDGVRPILLCTLVGGVVASCLKQRLGLVCRVAVSGLGVAKLLCALGYAHVDWGCLFRDLLGIWALSGSDGFLHAIGSALFGSLWRGCAFFGGIIGGFAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFY8</accession>
    <name>F9WFY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002203">
        <property type="protein sequence ID" value="CCD16218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11660"/>
    <dbReference type="OrthoDB" id="1721674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021502">
        <property type="entry name" value="DUF3158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11358">
        <property type="entry name" value="DUF3158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20268" checksum="4482392B5958A63F" modified="2011-10-19" version="1">MGQIPSNDGSLQQTAFRPLQQEAFQRLQQAASLKGLLKPFKGKGELTQFADLCRAQESDLKALAQEVLSQARRYPFTLVPVRLTEQNTQAGTQFLRWQQVTDRRMGVGVWAEMMGSPRTPESMLQDLYVMELQRITLNMQMSLLHSITKQAAECAEKMGQAEAVYTARLQQLNNPTQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ9</accession>
    <name>F9WFZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002209">
        <property type="protein sequence ID" value="CCD16229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11770"/>
    <dbReference type="OMA" id="ECHAQRY"/>
    <dbReference type="OrthoDB" id="1654545at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="821" mass="92212" checksum="9BEB3E745BABBA1A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG65</accession>
    <name>F9WG65_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002236">
        <property type="protein sequence ID" value="CCD16299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12390"/>
    <dbReference type="OrthoDB" id="1665318at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390327" evidence="4">
        <location>
            <begin position="25"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="86"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="401" mass="44171" checksum="BAD9EDE91D603937" modified="2011-10-19" version="1">MMIMKIWIVVCLVVARGWVKEARAQADVTVNTSDNVEPFSLLCRIYKVAKNPPIKPVDTKDYQRIVEEIDALSALVSGYERVNPKTETEKLDRQKLTEIAGDAQKIWDEVKKVNLNGEAENAKDAFNKVIFGEHGVSETDLRHGAFKGVGENRPTACGGTNLEKNEGSSGKNLIVDFFCLCSNRNMVSEGVDKVCGVSVGAGKDSGWGPKLYSTATMWVEIKNGCEKFAERSSTSTQVGHSLYSEFLEKVAEGGNVKVKGSGTAPKTGMLGTAVSDSKNANFNCNGQSSTNRFSGSGICVFYGDNKREDNIEWLKQFKTGLDIIDKLNNKTASWKNTLHTLKSRAKAIYERVMESSQLEKEDTEEPTQAQRLLSVENATTNNTTRSHSDHGRLILPWALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGA3</accession>
    <name>F9WGA3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12760"/>
    <dbReference type="OMA" id="HMICEGV"/>
    <dbReference type="OrthoDB" id="1686749at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30885" checksum="3BDE3480F8DF5B97" modified="2011-10-19" version="1">MYDAVFNAEWSYVVRSDEYSRKWLVVSVLGMAPGEQPHLWSGAQADVEPVVWEPWEGDVVPCVKVKLVMAFLSSVKGWPCGLFQRNEVPDASTLTEYDVTCDAYIRKEYLRVWHIVKEGLDQWMESGRVVLPLIVIGTSGIGKSFATCSLLLYQLLRYTLERLEVVAYFVEGKAYISYREERRVVHYEEQCLTVDKINHMICEGVEGYILFDTGDGNSGVERLPCDWDVFLISSPDRKKLKRFEALRPQKTIPVYMSCYEDAMFMAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE4</accession>
    <name>F9WGE4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01540"/>
    <dbReference type="OrthoDB" id="1714266at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390340" evidence="1">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19149" checksum="0AF46F24D0476AF2" modified="2011-10-19" version="1">MLQAMKAFGVIFMMSVLCSNAEWELPYSRKAVPTEAGESICSLSRKLKDVAAWTQGQLEALKKTRDTYASKLLDWQLHFHGSHECEVNQSMLEDIRTDLEKVNEEIKKLSGKAIRTGAFAAKSAGRLDEFITVFARARGIPGFMKRPNYCLGGGVSRRSEAICLSASLKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF9</accession>
    <name>F9WGF9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 498</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002268">
        <property type="protein sequence ID" value="CCD16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13190"/>
    <dbReference type="OrthoDB" id="1706808at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="19706" checksum="0B13A37EF5646ED3" modified="2011-10-19" version="1">MLFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMLFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFVSFLVFRHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGI2</accession>
    <name>F9WGI2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 504</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002275">
        <property type="protein sequence ID" value="CCD16418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13390"/>
    <dbReference type="OrthoDB" id="1653706at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="552"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="657" mass="74756" checksum="65E5894FAAA3D5C9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGL2</accession>
    <name>F9WGL2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002286">
        <property type="protein sequence ID" value="CCD16449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15640" checksum="A758DAD06070454B" modified="2011-10-19" version="1">MCMSHGFRNACQLALFHTYEAPGWGWSGQSSPYTPRTGSGNSRCPGSACGSNVRSRSLGVVGRPATTGLMWRAILALFFQCSQFAVPSQNATWQYTHTRSPPEAAGPIIRDGNLRQLPQLVVPLPPTGISTHSNKHTHFGGNTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW3</accession>
    <name>F9WGW3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 560</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002337">
        <property type="protein sequence ID" value="CCD16551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14650"/>
    <dbReference type="OrthoDB" id="1714261at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18748" checksum="3D16D9D6BCC03848" modified="2011-10-19" version="1">MPECQADHKENSGEAEIFCQIRLLAKSDPERLVTFPNEEWEKQMLRRIEGVGPEIRGLAGKADQRDASLITQFNDLVKEAKKIMGNMRDLRREAAEKRLSAKHHLHQVIFGKYGGEGKGELDTKAETVKKILINDFVLGNAGHLNTAPRCSFLRKGSQEPTPSTVHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGW4</accession>
    <name>F9WGW4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_14660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002337">
        <property type="protein sequence ID" value="CCD16552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14660"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389128" evidence="5">
        <location>
            <begin position="26"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="98"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="291"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="443"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="510" mass="57524" checksum="A059F970F70ED23D" modified="2011-10-19" version="1">MERGKMRNWNRIVAVWWVIVAVVGSEHYNKKEFEHLCKILKVAEGEPKKIPDELRKFTDTTRVLESLLRVTRTSTATYQKVVKLSSIDKEDADFVSYTVKRKTANAKIQHAWEKVDEIISRMEEELILANKERTQARNSLAHAIYGAQVGELPKDEEIPMVLKNVSRGSISNSNGGEKKVKYHGSSTNPTCGGSGESGAGFTLINDFYCLCAGKESNHTVCHQDIRGPAKWNDEKKDDTIEEEFECKSCNGNCNNCPCCGGKCRQEDGKCKFYCDKGKCDKDCKQCKEKCCCCKDCDGGCNCGQECKDGCCRAGPYGILEGEWLKLNITEKGESKTVEFEKGWPHIRKVCEEVFKDKINTTAESIQEVLDEFNKLLGGNTKKEIEPKSAEMDARRLFVLGFVKNMGSGCKGVHKHNQQGDVGVCVNYWAVSNLGIGIVWQNYMLEAQKQLQAMDKHIQKAQQLSRMIQKLKESAEESYRNSAHEGMLWPLQDGSRKNTSHNFLIFFACLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH37</accession>
    <name>F9WH37_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 588</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002368">
        <property type="protein sequence ID" value="CCD16626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15350"/>
    <dbReference type="OMA" id="SMQIRVR"/>
    <dbReference type="OrthoDB" id="696152at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="277" mass="29797" checksum="65099BBCEEBE4F93" modified="2011-10-19" version="1">MSSALRSLREAVAHYEAGDPWSARGATEAALHAAQPNEHEPFAEALLLMANICAAEGDLVTAERYAATCSGYVDEHLGPQHSGAAVVRLNRAVFMLEGYRLAGSSDILLVEKAHALLIEAERFLTNVCGVSRLVLAEVLHNSGVCLSLLGRYVAALTAYMRSMQIRVRFKDAAGVTDLRLALTMEHVALLYRLMGGPKRQEAALLMEVVASTRRRLLGPQHPLWAAAVLAQGVIAAELGQRSRAQSFLRGASVALSSHYGEESPEAQYAVKLLVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD6</accession>
    <name>F9WHD6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 632</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_16340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002417">
        <property type="protein sequence ID" value="CCD16729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16340"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="244"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="46496" checksum="4459C8C02D96AD85" modified="2011-10-19" version="1" fragment="single">MFVDTGEEERLKEELHELRKECIVWKDMANFKKELTQESAREQRVHEGHAVDLGLVMESCAEFLELVAKVVEPLEPKGSDAERLKKSIMLEKLKKGLTKWPEYFETKKNCWQKRLEVEEEVTENDAVEKELKEQEKQVDELEKELETIEEKIKKDIVPMQQSDPEQHPCPYCDRIYASAKWLKRHVREDHPGQPTTGIDEDRVSFECPHGCGKTYQTRGWLMRHLQDKHGERPQSDEAADSNPIYCPHCDRIYASVGWLRRHVRKEHEGETDPDTDEDRVSFECPHGCGKTYKTRGWLMRHLQDKHGERPQSDEAADSNPIYCPHCDKKYASVGWLRRHVQKDHEGETDPDIGACGMRVPCPFCDRKYASFVSLKKRLKDKQENEAITGSDEGSVRLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ3</accession>
    <name>F9WHJ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 656</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002444">
        <property type="protein sequence ID" value="CCD16786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16860"/>
    <dbReference type="OrthoDB" id="1719972at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20170" checksum="E9F64E4D6F2EFEE6" modified="2011-10-19" version="1">MPNKEIEARLQKESKKLQPVGDRLRAFCFSNSGIEKSAEELQSIVGRLRDSKNQDILTKELPAFVNKLQDVAAQIPPSRRTESSEVLEELPLIEAEIRSVLDQLQDAMKGFQSAADRLKALCNREAKEVERAAEELQSMADRFGTPDTPKILEEERPAFVNKELATCGRPAHSLKPWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-02-10" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHP7</accession>
    <name>F9WHP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 680</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002470">
        <property type="protein sequence ID" value="CCD16841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="947320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028648">
        <property type="entry name" value="Vps5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="PTHR10555:SF170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="SSF64268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="305" mass="34149" checksum="2E40BF543D9BCCE6" modified="2011-10-19" version="1" fragment="single">MSEDSTGHRLEFFVAGAERVFLENDNTLAFSHWSYKVLTRSFLESYQNPPILPCSEVQNNFIKGDGYIDYCTWHRYSDFQWLAAEVSKELPGIIFPPIPEKDINGTIDKLTAHFVGSDGLDASTNELVSQRSRRLQMTLNALAQTDIAHESQAVMAFTTLEEVEWHKFRESRECADKPSFFSSIRESCSDFLERLGVSGGARDAGHSISARLDSIMERHEKMVDIIKKCSDAVDRMSKSCLMDLPKRKKLANISKPLQKCDLPATACCIGSVVECSSPRGRIGVVKDMDGEKALVDWVGHEGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHT6</accession>
    <name>F9WHT6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 694</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_17650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002485">
        <property type="protein sequence ID" value="CCD16881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17650"/>
    <dbReference type="OrthoDB" id="1667225at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394784" evidence="3">
        <location>
            <begin position="24"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="47036" checksum="084E63C831C61535" modified="2011-10-19" version="1">MREFVLRGYWYSVFCLLFVLTAATTFTTTAGGANSRCTASVEGGENVLCRFTGLFHKSHGVSGKLLDVKGEELRGDIDLFKDKIHHIVGRISGLLGETNKFHQLSASDKKKIEKLCGDLQKKNEEQLVRISGAISPYHETARVGKKVSGDLLKAPVDGRTCGDNDDHTPVFEGGAANGGAKCQTLEGLCRPHASADAHEELSVDAAKCIYVGRHKHCHRGMGDEVEKVLREWGALKTSAHKPYGYSCKPNEQWKEEVRNLTVTMRSLDNLTTVISNATLMSGIYVTAVQNIINVLEYGYSLEGIIERAREAGKKGAVIELSSGGTPSGDSAPGADGSNSSSDGAAGTGSSSSGKAETTTLEEDVDLDLKMDDDVMPSSVRSSTLGMWLLATLVPFFIILIGVLVFCLVRRRGQGADADGKNSSVTGATMGKGAPGGVRGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI11</accession>
    <name>F9WI11_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002510">
        <property type="protein sequence ID" value="CCD16956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="699045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="114" mass="13015" checksum="A77C81EEEE4677F6" modified="2011-10-19" version="1">MNPLNCRNAWLTVSTNTENDGDPEERLLLSYDCGILVHTMGSVGLPSYLEYRLVLGCRLTFAANLKCTHISIRIAQLGNVVHKRTYFLHGMCPFCNWLQRIKLSPWNWDNLCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIP2</accession>
    <name>F9WIP2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 816</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002621">
        <property type="protein sequence ID" value="CCD17190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20270"/>
    <dbReference type="OMA" id="CIPLEMS"/>
    <dbReference type="OrthoDB" id="1479896at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24663" checksum="0DAC7355CD2C34B6" modified="2011-10-19" version="1">MHTTGTPLGRLKIRILDLSSLLDGASDSVYAGMYIVARLGADSQRTDVLRADAGTDGTGGRVWNEVFMFEIEGNSAPPVKTPPSTPSALGVDSAVAPHLPSLHERQAVRFPGSSYTLPQQSPVVSRGLLSPPSGFVGGMCGLPTLTLELWRHSPESDDCLAKYQFCIPLEMSDGNVIDRVVRLTSASPYVALFALRIRVALLDCDWSAMGYGRNALGVNPMSVSVFWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ9</accession>
    <name>F9WIQ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 823</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_20440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002628">
        <property type="protein sequence ID" value="CCD17207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20440"/>
    <dbReference type="OMA" id="MRIHKAQ"/>
    <dbReference type="OrthoDB" id="792569at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="PTHR13237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10" evidence="4">
        <location>
            <begin position="444"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="371"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="515" mass="58873" checksum="EC5FCE145971FDB1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY9</accession>
    <name>F9WIY9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002659">
        <property type="protein sequence ID" value="CCD17290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21200"/>
    <dbReference type="OrthoDB" id="442980at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="PTHR22589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carn_acyltransf" evidence="1">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="205" mass="23329" checksum="5FB54508C346C408" modified="2011-10-19" version="1" fragment="single">MATVAATTGRRRVPEALPLASIQQVLQTYFQLLEPLDTTAGKEETFAFVRGVLSCLEGVEGKVAQDTWKDAAAVSYKRLYNKRFLTSHIAPSWYAMYLGTRDRLPFGWNYAYGLEKFPINGLWEKLQVSPQALTASIIGTASLHLRALLNNPKFGTPEVQNQMPKQCRIDLKICQDQLTRLFRTVRIPHKGMDSLRWTRRDNNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ27</accession>
    <name>F9WJ27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002673">
        <property type="protein sequence ID" value="CCD17328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21560"/>
    <dbReference type="OrthoDB" id="978394at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="40929" checksum="93BAC32FC096AF3F" modified="2011-10-19" version="1">MRNTAKQCRGVGDVLRALQTRGEWLGRNACVFFVGGPWHGVLRTWIDDHLHNRNHVKEGSCSTFPPKSEANACLTLNDEATKKASFLRSLVGDVAGDEDVESPSFCLFPGLGSGASSQIGVAGTTYELPFTVAEAAAHIRRQPGLFQAGGHFDRNHLPPRITGDQNVSSSAAHDCMNVFLRHRTADLIALDLDEEPAMEFASQCPAALTDYVEDIRNSLALSAYLLKPSGALLLRFPLYAMTNGVEEFRVLMRHMKCRFQVSAHEIEGGYVYYMGCRSVAGGMQAASHTTSFRPPADKPKGRFIKHSQRARANAPYFSALMPSYTNASRVKEQLESASLSTGEATGSAEVNAEAFFNMSVEMAEQGLHNHKRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ99</accession>
    <name>F9WJ99_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22240"/>
    <dbReference type="OrthoDB" id="1733792at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16632" checksum="B5618006FD266671" modified="2011-10-19" version="1">MKIPGSLLRRVGRTRVAPRLIISEPLSCSLALQLVKLTESRTLSSATLVPCDAALQLPGSEKQTAQRLRLQAAPSKSRSDGAGYAAPKRAVKRPQQPPTLGANSAMHLNKQLSRRKKESDGSVEGREPYSNEVTAPAAVPQLPRHTHRYNISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJC2</accession>
    <name>F9WJC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002709">
        <property type="protein sequence ID" value="CCD17426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02450"/>
    <dbReference type="OrthoDB" id="35879at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="972" mass="107519" checksum="C99CA8B6CA18B503" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP0</accession>
    <name>F9WJP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002750">
        <property type="protein sequence ID" value="CCD17547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23610"/>
    <dbReference type="OrthoDB" id="1669305at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="363" mass="41299" checksum="EA17D40E18BE3DC3" modified="2011-10-19" version="1">MNSLDNPQMTQQSFNHPDIGRERYETVDGFPPRFLRHARDAGDRMPLNMPNIPAGTQFIRPGSAPRMIADPEQRRRLATKMLEAEIAKHTLTNLHNARSDLRAFQSGIKDIEFTEEMQIALRTFQGTLYILEKYGPAVTIEGILKAHGASWTLHLQWMGRRDIHGNPINPNDTEGRFDKYRTVFQAACFWADHHERTLYAIAGPLGHQVQPFSQQDYSDMSSAFVTYVITILGKIHAGKLLSPAMVRHRYMKGISDDLEKAIDEHFNIFVKTKYKGVAQSRRPLIPGVKMAAMQRHFSGTGRQHRRYSPETRAGNNNSRRYQRFQSTETSKKTRGMLKSPGASRTPSPTSRKSTTAGKEGYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ0</accession>
    <name>F9WJQ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 935</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002752">
        <property type="protein sequence ID" value="CCD17557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23710"/>
    <dbReference type="OrthoDB" id="1098657at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="462" mass="51412" checksum="C521387EF6361BF0" modified="2011-10-19" version="1">MMSRMRMEHGVGDPGTVKASCSRRPLRHQKPVMKATDQEDNDDKKVSLEINESAVEEAILTVVMELLQRNSSAPVEVNNCQQITQMANELIEMDDFRYSQQRSTKHKAGPRRRAAPLSVFGGGMQAFAPDDAEAAESLYNCVLDALKKYVWSHVNVSPQQSGQCSFPPATANFALALQLDLMSVCLQVIETRLTCTKNTANSSVWIQYDGPRESEPLARNAVHCLPFESLGAKTSLRPIFRLEYWVTRENMWAVVEALMTSVRGGIVEGSDAYNVFNARSDTYVDPNALFPTRVPLFSLLPVDATQSARNDPELGRGKKFFSNAQGDDQVNDKNGLDKPCAEHFHVEPSALRSLAHIVSVVGTDIIEGDMGANQHNAKQRYSDATCAVVEAVRELLEDTGIRGAVQRRAKGKINEIAQRREVDERVSREERERNIVAAAEAEAEMVVQRILQELRVEEARNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR2</accession>
    <name>F9WJR2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_23810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002757">
        <property type="protein sequence ID" value="CCD17570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23810"/>
    <dbReference type="OMA" id="DAIQLQT"/>
    <dbReference type="OrthoDB" id="1004067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="SSF57774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="260" mass="29697" checksum="854AC53D2DD884E6" modified="2011-10-19" version="1">MSTGQLSAEAVEYLEKKRVTYLLEELFHDVLRHLPENPLEFLLNALDNKTTLQLIIVGPPGSGKQTQARRIAKRYGAVHVRAQDLFLREVANKTPEGEIIERCMAEGEEVPTHITSELVIRRLKEEDVVKRGWVLEGFPQTRSQALRLQTAGLPPLLFIVLDVDSEMSVKRCMGRQYDPITQNIYHADYLPPPVGMQVERLSPEDGSRAAVASGWKYFDARRDELVECYEPFYVRIEGSRTFEEVFTEICEQVDSRFASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJV0</accession>
    <name>F9WJV0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 95</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002776">
        <property type="protein sequence ID" value="CCD17608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02560"/>
    <dbReference type="OMA" id="HELAHYV"/>
    <dbReference type="OrthoDB" id="11084at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026975">
        <property type="entry name" value="DNAH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="PTHR10676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676:SF358">
        <property type="entry name" value="PTHR10676:SF358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="457"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="650"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1864" mass="208810" checksum="AA137CAC81972EF6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK00</accession>
    <name>F9WK00_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 973</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002795">
        <property type="protein sequence ID" value="CCD17661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24650"/>
    <dbReference type="OMA" id="INFRACA"/>
    <dbReference type="OrthoDB" id="1319375at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="548"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="613" mass="66616" checksum="B80FA0D981AF3DEA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK84</accession>
    <name>F9WK84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_25290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002823">
        <property type="protein sequence ID" value="CCD17746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25290"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390521" evidence="5">
        <location>
            <begin position="23"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="96"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="50452" checksum="0CCF6A7F428A916A" modified="2011-10-19" version="1">MRKAMRILEFLFFTIFLGGASSTTGNELYNQEEFKHLCKILRVAEGEPPEIPDELGKFLETRKILEKLLRATKTSLATYQKVIQLKSSDKEDAEFVSYTVKRRIANEKIKHAMEKANDVYNRMEEELIKAKKERTLARSNLVHAIYGVQVGELPKEENITDVLQNVSKASIFNRWGGNKKINVHDDVPKDPTCGATTGEGAGFTLINDFYCLCVGRDNAKAVCHQDIAGPCCCCCEKCPKECKCDNSCDCKSKNCGDCKLHKKWMSLFDVGKGKLVDVPEGWKRIREACLNTSTETVNTTAESIQEVLDDFNKLLGNNTKGIESGSDAENESRRLVVLGYVKKMNSQYNSCTGSTDAVCVDYWTVLNNRHGIVWHTFMVQAQKHLQEMEKHIKKAQQLSTMIQKLKESAEESYRKSGHGSMLWPEDYGARENIWHPFFIVFAFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W369</accession>
    <name>F9W369_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1010</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000363">
        <property type="protein sequence ID" value="CCD11577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25480"/>
    <dbReference type="OMA" id="DLCDPLM"/>
    <dbReference type="OrthoDB" id="64894at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033304">
        <property type="entry name" value="DLEC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46348">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="401"/>
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            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="1822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1804"/>
            <end position="1820"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD11577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2323" mass="253539" checksum="977333BD8DBF0B1E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L7</accession>
    <name>F9W3L7_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1074</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="ICKRINY"/>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
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    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
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    <name>F9W3Q4_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1090</fullName>
        </submittedName>
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    </gene>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1727443at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="18530" checksum="9D574A15D6248FAD" modified="2011-10-19" version="1">MPGTEFSRGPSSSIAIASSKGPGLSHRGTPQVAQTLSHTVLLSFTLSFTQVKKALIHQPIHVLTFVPTSARIVCQRSSKSIPCSQSMNTDAARVALSSGVRAFPRNVHLVSPSLSHIHIPLFRRHSAYTSSLTTSRTHLHHTGSPKLPSALMSRGTSPPTTNSSLVPLALGPSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3R6</accession>
    <name>F9W3R6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1096</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000458">
        <property type="protein sequence ID" value="CCD11789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27340"/>
    <dbReference type="OrthoDB" id="42863at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026701">
        <property type="entry name" value="CCDC180"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21444:SF14">
        <property type="entry name" value="PTHR21444:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="174"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="820" mass="91480" checksum="A9F19CE4F7345999" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W447</accession>
    <name>F9W447_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000512">
        <property type="protein sequence ID" value="CCD11931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="15122" checksum="A1F6AD4CC7885FA1" modified="2011-10-19" version="1">MWRTLSKQQRECGEHYQSNKGNVENTIKTTKGMWRTLSKQQRECEEHYQNNKGNVENTIKAAKGMWRTLSKQQRECGEHYQNNKGNVENTIKATKGMWRTLSKQQRECGEHYQNNKGNVKNTIKATKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W473</accession>
    <name>F9W473_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sld5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_02610</name>
        <name evidence="6" type="ORF">TCIL3000_0_28940</name>
        <name evidence="5" type="ORF">TCIL3000_4_4120</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575317">
        <property type="protein sequence ID" value="CCC90297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000525">
        <property type="protein sequence ID" value="CCD11961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_4_4120"/>
    <dbReference type="OMA" id="DVREKLC"/>
    <dbReference type="OrthoDB" id="1291729at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="PTHR22768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="SSF158573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld5" evidence="4">
        <location>
            <begin position="53"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC90297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19978" checksum="67140293388AA509" modified="2011-10-19" version="1">MIKSYFDIASILVNEEPVPAIFLAPLFGLGRDIGPRTADGEVLDDVQSGSVATVPMWAAVAFRQDGLLIPQVPPRYTTSVFREFKTDPLAVSLYGKSPYYYEAGLLLCAMLPTSDGNRLAGQLFRLYQLRYLKIIRSAAKKGFDLSDVRGKLCESERDLLDALIRGMEEERQWYQSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A4</accession>
    <name>F9W4A4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000533">
        <property type="protein sequence ID" value="CCD11993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29180"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19601" checksum="C90339A32E2762AB" modified="2011-10-19" version="1">MTARGSQFAETADKIYPPQHATHSRLEKVRHMHGTIEVPIKPHEATVLQLAERACLNTAVPGGHKTETPEKEERVHTMGRVQRFNGYGYQLWTDGSVTLDVSSGAEALVCLLNGKREKVTLCGGNLDSSFRVECVAVEAGLHRLLRIIEMNESRKTRVVAFTGSLSLLVALKQELRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4E1</accession>
    <name>F9W4E1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000545">
        <property type="protein sequence ID" value="CCD12032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29520"/>
    <dbReference type="OrthoDB" id="1724835at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="195" mass="21677" checksum="47CE6F0A6A3CC7C9" modified="2011-10-19" version="1">MSSASGTRRQYQHHALSTCRIRDDYVQLIGPRCGLCQARLEALRLLVSLLVVLVSRSPSFSAAAPLTKGREKEGGNGGRTRGRGRCAGRHAAGYVGEFLRSQCSLSIPPRQIPKGLENVYPHPGHQAMEFLRHFFPKQCIQNTTLGVSEKIPQNKTVVILFRHREQGIQKLVQVCGLRVLDAFQEDDSNIRLHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4E8</accession>
    <name>F9W4E8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000546">
        <property type="protein sequence ID" value="CCD12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29590"/>
    <dbReference type="OrthoDB" id="1540820at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389788" evidence="1">
        <location>
            <begin position="22"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="205" mass="22174" checksum="AA41B227AFE65B7F" modified="2011-10-19" version="1">MFFLCFFSVLTLHLEIPPSKGMRHTRFYCFIGNNGPGVLGSWLGNVANSLKGSMSKSGAGFLSTHAGTGSPLFVSKHLGGFSGMFSSTGNASGSGGRNADDGSGGGTFGGPFGTLFDKALEWCSESHARDIARREGIDVRDIRFEKTPEGGIKVIVDAPSATFKQIEQLGEKVMEECPVARFRKTQVTSPQQKVEWVRLPDRYDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G4</accession>
    <name>F9W4G4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_29750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000551">
        <property type="protein sequence ID" value="CCD12056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29750"/>
    <dbReference type="OMA" id="GWNRAKG"/>
    <dbReference type="OrthoDB" id="1661083at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="677" mass="79760" checksum="740EED628BCEA9D0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4M0</accession>
    <name>F9W4M0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000578">
        <property type="protein sequence ID" value="CCD12114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30280"/>
    <dbReference type="OrthoDB" id="66074at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="557" mass="59350" checksum="4684350376EA3C5F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V9</accession>
    <name>F9W4V9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000620">
        <property type="protein sequence ID" value="CCD12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31100"/>
    <dbReference type="OMA" id="GFRHTHS"/>
    <dbReference type="OrthoDB" id="1171283at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="345" mass="37071" checksum="F5C19DBBE39E28FB" modified="2011-10-19" version="1">MLLRVRGNGASAENSQASLVHLRGFRLTNTRPPTLESKLDGTVRPMLFSHFHVGVQIPEADSNVDLSAQLCSAVWREIWNLYDIVYDELCIFPPEAVVVTSLVASGGASQQAGCVGGYAQLTKRQSSQTPVVVTHYFPEGPMQLRLPKDAGSGQLVVLDVSEIPLAEAGTKIATEVAWLAAYASLRGALDTVRHVVVRLPYACKVTEGVKEPTVQEGLDFVAQHLALLVRDFSHETEATGASSSCGVNVHFVGAAAEELEVVLKRLISDRGGTGASVIFIGDHYEQKDRPAQVRELASAVDTNLQLELVPLKAFISGGEVSWDAATSRENRVLNFCPCCGHCGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z2</accession>
    <name>F9W4Z2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_31400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000632">
        <property type="protein sequence ID" value="CCD12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31400"/>
    <dbReference type="OMA" id="MDCLKSW"/>
    <dbReference type="OrthoDB" id="860126at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:Lys48-specific deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="PTHR12473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4205" evidence="3">
        <location>
            <begin position="212"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="456" mass="49992" checksum="C05A3CB40E0FADB8" modified="2011-10-19" version="1">MPPKKDSDAPVYSLPHERQVELLSEALLREYMHKRKFTETLRAFDEENPRGSDTISSRALMSDLMTLKPETQKSMKSDGIETIMEMLCCLRVRRRLEVEDLKKRAAAKPPPTPEKLKKKKRKNRDGSKGGKGKNEKKRITAKEFEEDSSSNSDPPDDDAKHKRREPRGSFGYEDHSGDDSGNDGSLSDHVFNSADKNGPKTQVGKKLARSMMSLLCNDDTLPESFLKQGFVFDDDVDYGLIQWKRGPDGVMAAVQAFVCAFFFKGACMDVRRHQKQCLFRSLMTILYNAQPQARLVCLVDGAINTDNVEADMANLTLRCEFATLQDVESTLRGFVDNWTQPKGSGVFCFLISVLLSRGLKTVAAGCPAGSRLINPEGNCSEVLGKLFMPSEASGSSAPGDDDEFVLGSLALGMGSGGITCGFLTRAHDGTATAVYPTPSFPCVGSRITGGILPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W500</accession>
    <name>F9W500_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_03250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000638">
        <property type="protein sequence ID" value="CCD12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1482469at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="2">
        <location>
            <begin position="64"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18858" checksum="3C00F98CB3B2F6F1" modified="2011-10-19" version="1" fragment="single">MPEPIPIKDHEKENRLVNKRLLACAVLVIGITCALVGRMYFLQVVQYDYHSTISENNRVHVLPITPTRGLIYDRNGVVLADNRPSYNLTITRERTADLKGELDEIVNLLHLPAEDRAVFDKALKQARHPFVPVTLFYELTEEQIAVLAVNEFRLPGVDVEPQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W548</accession>
    <name>F9W548_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1275</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_31920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000657">
        <property type="protein sequence ID" value="CCD12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31920"/>
    <dbReference type="OMA" id="PWIVGFR"/>
    <dbReference type="OrthoDB" id="1286274at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="513"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="996" mass="105744" checksum="194AD017A619BA4E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W549</accession>
    <name>F9W549_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000658">
        <property type="protein sequence ID" value="CCD12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00260"/>
    <dbReference type="OMA" id="RDMEAPV"/>
    <dbReference type="OrthoDB" id="569938at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="PTHR12507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="442" mass="48710" checksum="3F707EF859391F4E" modified="2011-10-19" version="1">MLAVNATLHREWYAPGDVVQLDVRLCCRPAGESFLSKVYAFVENWWSVSHSSTSSSTTDGKEQLSITLSSLTGRIVGACVVNTRLIQYALEDGKGTTAYHCPQLLDETSLKNHRVYKLFSSDEFTVASDLTICQQEVKIFGITAVLPDNLPPSFKGRSVCFYYGLQLSARCIAEDKKSSLKLLRIPIKVFSSTAVYTPLLLPLSFPLEDFDFGATVVPKEPCTNADTLKTTGSVPELPACRNITTMLAERLAKQKTPIDYPLTISGEVALRVVVTSTTVMIGSSLNAVFLQGDARDCRAVMVLGTLEVLESVLAEHICRGVACLKPLEGDSRLVTQTTVVEEFQWNLMGRPRAPVYIPFTNLNYFATMQTDVVTTSWQLRLRLLWCKTSSSSSFSSGFRNQIAVEEDQPELVVPLTVVPPPPLPPCGIPEHPSCRVTHELCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W590</accession>
    <name>F9W590_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1296</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000681">
        <property type="protein sequence ID" value="CCD12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32300"/>
    <dbReference type="OrthoDB" id="1715945at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16868" checksum="72DC2B3CF67BDE9B" modified="2011-10-19" version="1">MQLGQQIICTNVGNNETHFQCISQHPNTPAPCRGQKPQCGQQLLHFFGFHHVPQVLGCAWCRVVVVILARGNTRGNCTSAFYFIPSSGSTASRQYPHCLAAYRNGERCDTSHHVHMTGPVYSSSLQWLKYSTVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G8</accession>
    <name>F9W5G8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33000"/>
    <dbReference type="OrthoDB" id="1730284at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17193" checksum="204DF94DF3B18988" modified="2011-10-19" version="1">MLIGSAEGNSPPKTHPIVAADSLLLPSSVFSSVSSALRGVELQHIPQERLAQHQAYFTAKDGHIKAHLDGEPSSLNAQIACVLLAAFESYMSIPLVSSTNPSRPLHLTAIGCLSAIPKSILIPDTLDSENRTSVSYRSFFHSALRRTGQMSPCSPGCLLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J2</accession>
    <name>F9W5J2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000718">
        <property type="protein sequence ID" value="CCD12444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="111" mass="12342" checksum="415F5B5E206D7E6A" modified="2011-10-19" version="1">MAVWDSVLEMEPACFSSEWWPRLTRWCGGSVRHCGTEPRLVVAVAVHPLKSPQTPRVWRAARDIGGIPSVGVVSRGTHNSHISESKLALSQVSCHEDLEMQSHLPHISLHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X3</accession>
    <name>F9W5X3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1396</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000792">
        <property type="protein sequence ID" value="CCD12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34430"/>
    <dbReference type="OMA" id="WMLADVG"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="675" mass="74408" checksum="210C4E835CD0411B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P8</accession>
    <name>F9W6P8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000907">
        <property type="protein sequence ID" value="CCD12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36960"/>
    <dbReference type="OrthoDB" id="1745491at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18913" checksum="B1424CFA85A3E12D" modified="2011-10-19" version="1">MVEQFLVFFASWYTHIRLTSFSELCVYLNLNLVVSLSFFFSPRFFLFHCVFKGRVATLSVSATLFGTRLVLFFVWLHLRFRPLCLRVSVCEACLVACLSALERVVVVVEKCCYDKERERRVRSESECVFRGTLEKVGKGKRVTVVSAADEVKKILFFFFGCDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R4</accession>
    <name>F9W6R4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase B-like</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_37100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01000919">
        <property type="protein sequence ID" value="CCD12871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37100"/>
    <dbReference type="OrthoDB" id="724258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PTHR12370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="25330" checksum="570A591D0A6A7020" modified="2011-10-19" version="1">MWKKYGDFYSYKNYSRARIFARDEGKVEDLASMKRLMRYNNYTKDPFSLIPNCSRTNSSFDDEETAPSVCKPPYSAMLSIAARGDLNPTGNDTFYGPLYRSVGHVDSAATDAKIATWSGMMKGNGTYTAHVICGPTTDGLPPFSWKKDIFDPMPPTYGLPKVYNFSFVVMTTVLPSPSKGSLWSRTGIIAIVAALVVGTIAVVLMRSRKDSEEDDALPEETEGLVDPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R5</accession>
    <name>F9W6R5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1511</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000920">
        <property type="protein sequence ID" value="CCD12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37110"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="23042" checksum="1E69A85FEB9DDA50" modified="2011-10-19" version="1">MVQECKNERKRDALIRWRRKVLVDTAMGRWKENVSKLSTTDSASWNLVKSIYAPRPLTSRMLVVDGHPLTKRQQAQALAKMYMARATKAPHAPEMEIPSTRRSTFRHITEAELDVALRELSSGAAPGDDEIHCEELKELGRVAKKCVLRLFNCSLRMGQVPAKWKHGIIVPLLKPNKPASSMASFRPVTLTSTLCKLKERNRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W712</accession>
    <name>F9W712_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000960">
        <property type="protein sequence ID" value="CCD12970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16336" checksum="DEF931E234C186E5" modified="2011-10-19" version="1">MIIIIKQWDEVTRFRISAQESGTYRLCAHSLIEVCTCNAGRDMGNQYNPASHCVRQLLSPVMRAPLVKLHPLNAHTTRAFCAEKKNTPKTSSCPHSISYRVQAVPSLSGSNSIQKNEKMHKTTHRSVKRGEDYDKTQGEYQRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W725</accession>
    <name>F9W725_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000967">
        <property type="protein sequence ID" value="CCD12984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38020"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45798" checksum="D079C84FED761862" modified="2011-10-19" version="1">MATYQKVIQLKSSDKEDAEFVSYTVKRRIANEKIKHAMEKANDVYNRMEEELIKAKKERTLARNNLVHAIYGVQVGELPKEENITDVLKNVSKASIFNRWGGNKKINVHDDVPEAPTCGATTGEGAGFTLINDFYCLCVGKDNDKAVCHKSIKGPGKWVQKDCDKCDDCCKQGTCCCCCNGGCKAGCDCNKDCDCNQKCNCGRNCKACVLEGEWMKMRNESGENELELEKGWPHIRRVCNETFTDKINTTAESIQEVLDEFNKLLGGNTKNDIKTEGSNAENESRRLVVLGYVKQMDTNYDSCTGAHKQPYAGGMAVCVDYWTVLNNRHGIVWHTFMVQAQKHLKNMDKHIQKALRLSRMIQKLRESAEESYRKSGHSSLLWSEDKGFRKNICHLFFIFFAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W784</accession>
    <name>F9W784_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_38650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000994">
        <property type="protein sequence ID" value="CCD13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38650"/>
    <dbReference type="OMA" id="YPRINRF"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="744"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122559" checksum="50A85EF0D4C26B69" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7L3</accession>
    <name>F9W7L3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001048">
        <property type="protein sequence ID" value="CCD13181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="16173" checksum="DF9485055F06AA02" modified="2011-10-19" version="1">MKKGSNFPSEPFPLCLFTSVFQFSPIFCPFKYKKIFLYLKVRVFGAVLHLHRFFLFFAFSANIYTQFPHFLSVPRNDYKKTFPPRRCTSCTFAVCCFFSFLFLLCFILIYIFFLFCRFSFCLYCSSPQEVQSRLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W841</accession>
    <name>F9W841_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1701</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001131">
        <property type="protein sequence ID" value="CCD13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41240"/>
    <dbReference type="OrthoDB" id="1729181at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17351" checksum="4B773B3FD08E20B3" modified="2011-10-19" version="1">MSVHRCSSIKPLSSRVVNFSHKNVFLSFSSFLIEEQRRLVSTMSRDNYYGSRALSPVSSSPEEQSHVGKMSGSDPRSNTMFARVLSKHADFSATMFPLPTNKRSNEDEEGEPVHERERSESEPPKKETTVSEKERNKDMGEKKIRTPSFVAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W880</accession>
    <name>F9W880_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001146">
        <property type="protein sequence ID" value="CCD13408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41590"/>
    <dbReference type="OMA" id="STMISKW"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34858" checksum="C5302893F54B1C0B" modified="2011-10-19" version="1">MAALSTTGIFCPIRDKWHVDGTTNMVVKLVRAQSGCPEEARNEAVCTYVRGRILEEAMEDFAKRELRRDVLVSFKKRCVSTLEASGLQAFMIGSVVTEVVRHLKYLPREGETERSRSSVLCRPAARGRVPTTFHRFSSADTPVEMVAECLYKPAEKNFPVVGGFFLVDAVGEGVSFPEGAEAPTQTIVLLQVTRARNQRTSTCKVCRLRERLAASFSNWREMESSLSYEIIYVQHANSAAIATRQRCDRSGTVSDLASERFWGGVDQFRVKLEAPIAKLLLQEIYDAKITEDVAAIVRDLRGVNITAVAGADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D0</accession>
    <name>F9W8D0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1728</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_42110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001162">
        <property type="protein sequence ID" value="CCD13462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42110"/>
    <dbReference type="OMA" id="QQRAAIH"/>
    <dbReference type="OrthoDB" id="1608420at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="PTHR14369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SURF6" evidence="4">
        <location>
            <begin position="18"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21949" checksum="EBDC3899F96D0819" modified="2011-10-19" version="1">MNVCSGRSEGAMKTIPLNLSFGNFEFNESKRFGQRGGGMRELSAALRKAQQRAAIHSQMLQRKGGLEERNADLLGTAIRRAAGERVKDDPKRLAKALAKRRSKKRSSAKKWAGRLEQIKKSVDNVVEEKGTSRAKKWQQKQSLSNGKKDDKSRKSFKEKSSRGGEKRGHSVRNKRNPQGSSKKAPMVSTKKARRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8W3</accession>
    <name>F9W8W3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001229">
        <property type="protein sequence ID" value="CCD13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43870"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="665" mass="76739" checksum="07D94C723AD4F1EE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K6</accession>
    <name>F9W9K6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_45980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45980"/>
    <dbReference type="OMA" id="INILDIM"/>
    <dbReference type="OrthoDB" id="517680at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="8">
        <location>
            <begin position="1066"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="757"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1449"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1449"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD13908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1534" mass="163719" checksum="C04B0289113DACAB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P2</accession>
    <name>F9W9P2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_46310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001334">
        <property type="protein sequence ID" value="CCD13946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46310"/>
    <dbReference type="OrthoDB" id="1666205at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="34"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="107"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="430" mass="47258" checksum="30F11FFAE1474831" modified="2011-10-19" version="1">MLKLFRKESVIMVCYMSVIAVAVVFGCFVRDVRAQAKGTITEGDNAEQFALLCQIYNVAKNPPIHHVDLEDPIKIVEKIDALNATFAEKTQFNETEPVENSSVAQVKPTATREAAVAQAMIRRIAQKAHTILEEIKKVNATRDIEKVKDEFAQVIFGEGMNESHLCDGALKDVAERGSACGSSGLSSKGKSAGKNLVMDFFCLCSQNTKEGIDNICGFAVGRKGALSEKHGWSEAGLWGSSAMWASIKKGCGRLMQQHTKSITESFDLIGDFLQYLRTGGVFRHDTKDESDRIVGMLGTSVFKKGTGEVKGPVCDGKKGGTKGSPGGMCVYYGQESEWQNIQWIIKLKTSLSMADALNNQTATIQRSIKKLQTLLHRGEEIYETTKVITEIQNPVLPTNLQTTATKRLTAYSGARRYPTNTHFLLLFILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T2</accession>
    <name>F9W9T2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_46710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001342">
        <property type="protein sequence ID" value="CCD13987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46710"/>
    <dbReference type="OMA" id="FWYEGRD"/>
    <dbReference type="OrthoDB" id="622098at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="778"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="799" mass="90252" checksum="17B1367CA705CA60" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9V9</accession>
    <name>F9W9V9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1904</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001357">
        <property type="protein sequence ID" value="CCD14014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46940"/>
    <dbReference type="OMA" id="CDANITA"/>
    <dbReference type="OrthoDB" id="1655902at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="661" mass="74409" checksum="481A19B5EC579144" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9X7</accession>
    <name>F9W9X7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_47120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001363">
        <property type="protein sequence ID" value="CCD14032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47120"/>
    <dbReference type="OrthoDB" id="1030784at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000840">
        <property type="entry name" value="G_retro_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036946">
        <property type="entry name" value="G_retro_matrix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010999">
        <property type="entry name" value="Retrovr_matrix"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01140">
        <property type="entry name" value="Gag_MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47836">
        <property type="entry name" value="SSF47836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="SSF47943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="2" id="KW-1043">Host membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Gag_MA" evidence="6">
        <location>
            <begin position="60"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Gag_p30" evidence="7">
        <location>
            <begin position="269"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="325" mass="35880" checksum="079A4A20370BC13D" modified="2011-10-19" version="1">MGSWVRVPPRAEGLNRPALERPSDSLSCLWSTRSRHCFWFLFCLSLVFALVVSTIILEMGQSVSTPLSLTLEHWKEVQVRAHNQSVEVRKGPWQTFCAFEWPTFGVGWPPEGAFDLSLIAAVRRIVFQEEGGHPDQIPYIVTWQNLVQFPPPWVKPWTPNSSKLTVAVAQSDAAGKSGPSAPPKIYPEIDDLLWMDSQPPPYPLPQQPPAAAPPQGPIVRGAQGPAGGTRSRRGRSPGEEGGPDSTVALPLRAHVGGPAPGPNDLIPLQYWPFSSSDLYNWKTNHPPFSENPSGLTGLLESLMFSHQPTWDDCQQLLQVLFTTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA51</accession>
    <name>F9WA51_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_47710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001391">
        <property type="protein sequence ID" value="CCD14107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47710"/>
    <dbReference type="OMA" id="RASYMQI"/>
    <dbReference type="OrthoDB" id="424630at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="99"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="820"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="198"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="886" mass="98265" checksum="34BD314F0EEB08FA" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA79</accession>
    <name>F9WA79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1946</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001404">
        <property type="protein sequence ID" value="CCD14135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47950"/>
    <dbReference type="OrthoDB" id="1721105at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18025" checksum="05602A281777B7C6" modified="2011-10-19" version="1">MNSSRRPAEWTAKAAALDASLSNCSTSFLVLSISFRTCRNRRSLILHAFEPLPLDLDCTHFFCHSSKFISMCVTSSAPSSTCCVVQGVMFFKVLLKVHMVAQALVWMAWGPVPKMSSASRSNMEEVRSRHHLERNSITLGVNRYSILLVTLRSFLKIKKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG3</accession>
    <name>F9WAG3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 197</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001432">
        <property type="protein sequence ID" value="CCD14225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05220"/>
    <dbReference type="OrthoDB" id="1522976at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="302" mass="32097" checksum="842D8D4023BA0267" modified="2011-10-19" version="1">MPPPPGGSQAAPPAPGRDHEIIPADVPPAYDPSMPPPPGGSQAAPPAPGKDHEIHYAKVPPAYDPSMPPPPGGSQAAPPAPGKDHEIHYAKVHPAYDPSMPPPPGGGEAVPTDYYQHPLLPGYGQPPHVERSGGLANEPAGEGGNVVNEWKTGLLVAPCRQPCFCLGSCFCPCCCTFMQRKKLLQGDWSRYTCCAGICCEKTCCVIKKCEPCCLCLETCCCLGCALHGNRFMIREHYGLQNDCCDDILMCAGACCGILACCTEKKAVKSIADILFFCTIGCVLAQHEHQMKVCGYPRGHEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH0</accession>
    <name>F9WAH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001433">
        <property type="protein sequence ID" value="CCD14232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48770"/>
    <dbReference type="OrthoDB" id="1710325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21471" checksum="52AC86C0522F1A4C" modified="2011-10-19" version="1">MSPARQSYFRPIHTSPSISLCPTLTAASQVVAADGRLCNAPRQMVRGSHISLAGLKLTHIIEHSARLPKAFPFTTSGTFSGSHRHTHIRSHRDATCTPMDAATRSHAFASRRHHRLPTHHMPQPPERLIGARQTHERHDVEPYAQSGATLLISNGAHRAQISHFHFPLPDKANSPRTNTARHHHEEKQWKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI3</accession>
    <name>F9WAI3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_48920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001438">
        <property type="protein sequence ID" value="CCD14247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48920"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394811" evidence="4">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="81"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="48079" checksum="8E5CB6688CE21C6F" modified="2011-10-19" version="1">MVIWRFALVALMFCIGASGSDSDPPSKEEFNLFCRIIKKANDMMYGSEYVYDERKDMEVVKEMEVFYNATTENINDLLKTLWDMKDFLKEHPPPMQLENRKQAHREIKYLIIDGEKKILENREIALEVNKKIKEAKLSVAQGMYGETVTQVPKEDGNFTDILSNTDSIFENNTTAKESCGHKGETSVGKTLINDIFCLCVGEGKDDGTSEAPCHKNILPPKKNRNNGGWTTMRHTSDRNNAISTAESFEKIEKVCLSLLKGKEQAKDMPALLEEFLEMIGKGSTKNNGNKIFGHSGRRIKNNGNNVTECTGAGTTGDGGQPDYHNDKICVDYTNNFKEGKNYKILWHNKFKNYYTFMDEAKIIEDKILKNHAEILLLKSKAWIAYNREKEDHTANLDDMNESQLFDGAQLTHIIPFPFIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAM9</accession>
    <name>F9WAM9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001457">
        <property type="protein sequence ID" value="CCD14300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49340"/>
    <dbReference type="OrthoDB" id="1213902at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="PTHR12547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25504" checksum="F76A73F102201A45" modified="2011-10-19" version="1" fragment="single">MTRNRRHDIVKSSKYKTSLCSFFLEQDGCSFGDRCAFAHGEEELRSEEENLRLRESRDMEEGHADVGQDCNSSMKRVSSLHSTDRGIDNVANETPDSDGGKTRYNLSRESELWFVKQSTPLNFSNQENKTKVGVTTSDNSSLKGIKPPPKITKGNSSKHSRTNLSGCTSKVRHGGFSCSMPPVTQYTSNGNGILYNLPGIGGTPEHLFQPTPGIGPATISLEVALPNVTSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV1</accession>
    <name>F9WAV1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001485">
        <property type="protein sequence ID" value="CCD14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="180136at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12471" checksum="E7CB6D25D42B8CE3" modified="2011-10-19" version="1">MQHHRHSGVNEVGRILPCTCGRAMLDARRILLLVSGDVERNSGLMIRGAQWNAGGLSQAKRIALERKLHEDMVLFCLLQETHLASAECAALKIGGYQHVGQARTPHGAGYLFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX8</accession>
    <name>F9WAX8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase B-like</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_50190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01001496">
        <property type="protein sequence ID" value="CCD14402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50190"/>
    <dbReference type="OMA" id="QTDEASH"/>
    <dbReference type="OrthoDB" id="724258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PTHR12370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="454" mass="51353" checksum="11B7607053E183D9" modified="2011-10-19" version="1">MQAENRRHCKGCAPLEVLEDLEQMMPRGLTETHGSALVKVVKDDIFFAHATWSSYNSMMRQYKTYRFGNRFVTMSSYPGAIHSIDDWYMTHSRLAVMETTNVVFNKTLIRRNLDSSAVATFLRAMIANFLAEDAPSWVKYFSIENSGTYNNQWMVLNMGAVKSTAMLKNMTRDTFWVVEQLPGKVAPLGITAKDMTSVLNTSGYWASYNRPYFPNVYNLSGIHDMWKKYGDFYSYKNYSRARIFARDEGKVEDLASMKRLMRYNNYKKDPFSLIPNCSRTNSSFGDEETAPSMCKPPYSAMLSIAARGDLNPTGKNTFYGPLYRSVGHVDSAATDAKIATWSGMMKGNGTYTAHVICGPTTDGHPPFSWKKDIFNPMPPTYGLPKVYNFSFVTMKFSVVPVVEFDVVWWLISGIGIVCTVVLLIIVLYLNIDCSSKKEDDALPEETEGLVDPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB05</accession>
    <name>F9WB05_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_50470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EMBL" id="CAEQ01001511">
        <property type="protein sequence ID" value="CCD14432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50470"/>
    <dbReference type="OMA" id="WMLTISA"/>
    <dbReference type="OrthoDB" id="29985at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="PTHR12389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="216"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29693" checksum="FC2BF02274E8D41E" modified="2011-10-19" version="1" fragment="single">SLLLTSAVPGSKRIESTYLCIGSGKNGIGEQLGFEIRALTCPNSDDPMRELAKGAAAVFALLLEANTLSVVSTWLGTLERKLQDCFYAFVEEHLSPTMIQGSLLEVVSKNSTGQSSFNVNENYHVSVSIPRSCIKLTYTMDDVRSSINIEFKSGFPLRPPVVMPENLRGCGVSSGELHAWMLKMSALLFGGSVNVWKCVMLFGRNMDEHFAGKEPCPICFSIVSATTNRLPDMRCAVCRNSLFHSDCLFSWWSSSGRTQCPLCKSPWVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB23</accession>
    <name>F9WB23_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001519">
        <property type="protein sequence ID" value="CCD14452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50650"/>
    <dbReference type="OrthoDB" id="26975at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="790" mass="85478" checksum="60114AF8B34BCCBA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB49</accession>
    <name>F9WB49_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001531">
        <property type="protein sequence ID" value="CCD14480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50900"/>
    <dbReference type="OMA" id="VKRIFIQ"/>
    <dbReference type="OrthoDB" id="994101at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="442" mass="48766" checksum="0020458B790C67D3" modified="2011-10-19" version="1">MTSPGWSSCDTEWGDGQVHDEPLLPELTIRGCGLKNFALLVRGAQGAVYSANDASGNRFAVKRLFTQRSDFGIRGVSEGALREATLLTLVTQRAAERGCERDFGVVTLHGVVEAPYKELCLILEMCPLDLSRVVIKRGGRSQGGQLVAETASKRCPILANVDVIRYLVRGIIEILQHLHDECRIVHRDVKLSNFLVREDGGVRLSDFGSARILREDVEEREATECKANPSYDGQTSERGSISSQEYVGYTPVAQRTTMIYQSPECLLGERSYSTGVDMWAAGVVFAELVLQQHLFHSASELSLISDIWKLLGTSSSDDICSSNRGAAGLSFVARTEPTIDLKFSNNILCADGLDLLKKMLEVDPKKRITASDALQHPFLNSQDTGLSLNDVRKMWREKVRQCQEEVTKPIPMGGPFAVFAQNGLEDEDEDDDDDEGVDVCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB64</accession>
    <name>F9WB64_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001538">
        <property type="protein sequence ID" value="CCD14495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="15689" checksum="9FEC3595B90DA83B" modified="2011-10-19" version="1">MHCGETLLPFTLHWAMPTLECVVHREGDHHRLVFHLSYGMRACASQAGAIVLVCAAASCTHKVSSFLRFHVPAYSSTFPRSLPIHIHLCFLHTLPVSGFYSFCSFSLYGGVVITALATATLRGLDVSLACDESTFCIDTLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBR9</accession>
    <name>F9WBR9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_52970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001620">
        <property type="protein sequence ID" value="CCD14703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52970"/>
    <dbReference type="OrthoDB" id="1715851at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="18187" checksum="CF9CD2F665DD40A3" modified="2011-10-19" version="1">MFFLIYLEDAVAILNSLCCSVPGIPGMVLLSFRPYRSTCPHRHASHQPEQLCQREFLGVCVSSWHWLLRFVVFTGSHPQSSPGVAGRDRDDPEKLSDAVPASPDTIPADMMREWDQDHYPPRSLLFFFFEALTIINPASGEKYDSRMIVLRCKGKWLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU0</accession>
    <name>F9WBU0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="109" mass="12197" checksum="5325BB55CB565CF7" modified="2011-10-19" version="1">MTARTTQRICPSELHSHVEQPPTGAPYCVSHALSLYLNHPNYTHMAMQCHGEFLVSDESRSVNMPCLTIPFHLLQVIILSGLYTLNIARENLSLLLVIGVYCRSSLSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBV9</accession>
    <name>F9WBV9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001633">
        <property type="protein sequence ID" value="CCD14745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="904786at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="233"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="757" mass="83239" checksum="1BD7BC5BA8ED0DA2" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBX6</accession>
    <name>F9WBX6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2158</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001639">
        <property type="protein sequence ID" value="CCD14763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53510"/>
    <dbReference type="OMA" id="WREMETR"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="617" mass="71048" checksum="40746BEA3513355E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBX9</accession>
    <name>F9WBX9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001641">
        <property type="protein sequence ID" value="CCD14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13356" checksum="22A79174B56B30B8" modified="2011-10-19" version="1">MDDVVRWALKVACDGACPRAPIPLLPPPDQSLGHGIDEVLLSTETLLKRNPKRFAIVLGASGLPEKVTIPFMVHHRLINFCESVERPVCYRYVAHDGGALRRICSLPSKGCNANQELQSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC03</accession>
    <name>F9WC03_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2167</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001649">
        <property type="protein sequence ID" value="CCD14790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53760"/>
    <dbReference type="OMA" id="VTHTIRF"/>
    <dbReference type="OrthoDB" id="1296572at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22161" checksum="7794DE87398849B7" modified="2011-10-19" version="1">MQEEVKRKSLASIYGITFHPMPDWAYDRKEVQLKEIVNQCIRRSSTRVCSNKRASSADKWSLAAKKPNGDYCRKVSKASSADDFGTSCYRLLDTPSSIASTKMSGGQSTVRNIVRFCGSKWGKILYGKYSKLESCVKEDIASCGVLPENIVNLKMKYTKSFVISFCLEGVPAGLEIAFRGRLKRCRFPHTTALYREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ6</accession>
    <name>F9WCQ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14454" checksum="C6A5A4B837AB5D1F" modified="2011-10-19" version="1">MAASCRLTLLRITFPSNITNGDIMHPSFIANKSTTHLSSQWDHFSSIFSLELRGIRCRYKARGSHRHSKKTYFGDLNDVFEPFVTPFEEPNYFPHFHYNHVISEEGSHPVGIFPMIRAITVPTTCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT2</accession>
    <name>F9WCT2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2263</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001757">
        <property type="protein sequence ID" value="CCD15080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56430"/>
    <dbReference type="OMA" id="WCACEDA"/>
    <dbReference type="OrthoDB" id="1694090at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="258" mass="27769" checksum="04DF4115B2BE4A9E" modified="2011-10-19" version="1">MEGAPLNSTRAPANGMFTIAYFPLKGPVSPATKKGPFATLSPNLVGESPKSDVGASSASTTTVGVARSRDDSECNEDGYFSSSDAVVSDGRRRSASLSRWCSRTESTIFMGGGMTPLAWRSREGSVGVCGDSMLGTAPATFAGAPAGAADKWPINTYFSPRPSYKQTLGSGGAQLAVKDLQSAPYHCYTRHYYKRHRSGVRCGESGGSRYGYCSLSRSGTGERETSVASPPVALHDYESKYIYIYIYIYIYIYIYIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCU5</accession>
    <name>F9WCU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001767">
        <property type="protein sequence ID" value="CCD15093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56550"/>
    <dbReference type="OrthoDB" id="1714263at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="19218" checksum="4F0619198279403E" modified="2011-10-19" version="1" fragment="single">MPDSRVIVGVNYRGKGVSPVNYERFREVRTPIHSRKEILRPHSPLFFSRSFRENIPIFPTVFSVAKPPSTACWVKGNNQFDQELRMCQRQRSAADDKIKIEKLRHVIATKPSEFNVDELYEAKCTAFRLQSRGIDTHSTEKDASVPIKHSGHCATAFVVPPVMQTKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCY6</accession>
    <name>F9WCY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2293</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001790">
        <property type="protein sequence ID" value="CCD15134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56940"/>
    <dbReference type="OMA" id="FTIVEKA"/>
    <dbReference type="OrthoDB" id="1585330at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="21521" checksum="04A71F2AC0CBAFFC" modified="2011-10-19" version="1">MGQKEEQVEEIRRLLHCGSTRADPFTVLQLDPQSCEMSDVNRSFRRIVLKVHPDKCSLEKAADAFHVAEGAHKLLSNEAAFVRLKIAYEKKKEREAALKEEAAKRQSRETSGATSSGHSTDPNVSVAERQRRRRHEQMLEQQMEATRLAEEAARKKQRIERETKEKAELAAELERQRKQWKDLNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC1</accession>
    <name>F9WDC1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001854">
        <property type="protein sequence ID" value="CCD15274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786872at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="17601" checksum="66B5642AF6C8DC68" modified="2011-10-19" version="1">MSACRRSGRRRLCFLSFFAFLSVGQIGCLSSSLRNGTTRFIIFHFFPLNYPVLPFAPFFFLLLLRVPTAFLFFFRYLLPALYFIRFRRPCHCSAVIFVMRFVPCTHIHIYIYIYMYMYEDMRQLTPSVFARISFLSFSFFFLSNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ5</accession>
    <name>F9WDJ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 237</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001877">
        <property type="protein sequence ID" value="CCD15349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06050"/>
    <dbReference type="OrthoDB" id="1201765at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20815" checksum="3BBCE0AFF00CD13F" modified="2011-10-19" version="1">MSMDICLQVVIAPVILKWFSRGSRALVCFCAILLCVSMWVSPLVAKHGFRLYFVVTMFLTDIPAAVLQLAFSTFPTDTFSSTEKEFAVKMQNYTKKVIKQWQPVFFMMLQYQFPEHAGLTRVFGFPLALGVGIYGLTSRFGLSAATIVVGYAVLVLTSPTDDEGMFGALNLLSGVEDSKLSLGVANLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL0</accession>
    <name>F9WDL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2377</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001883">
        <property type="protein sequence ID" value="CCD15364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="418348at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SSF47769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="24754" checksum="5306AB056090A0B0" modified="2011-10-19" version="1" fragment="single">MEPQLRDLLEQGGLAHTIQGFIDGEVLTLQQLKQLSMHNYQSVGVTVMTDRRKLFEVIQYVKREQATAPSGLNTSDGPRSTESAPLASGARNTTPNCRNTTPSSAQRKADNEGARLNESRHAPAAGNRHDPLNAVDDMELSVSKMTPGSRPLSRVARPSPIATTRKPGETATTKRKASRITVVVRKRPLSSSEISDGLYDILATDPDNLQAIALLEPKQKVDLTKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR4</accession>
    <name>F9WDR4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2392</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_59400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001900">
        <property type="protein sequence ID" value="CCD15418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59400"/>
    <dbReference type="OrthoDB" id="343657at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ULP_PROTEASE" evidence="3">
        <location>
            <begin position="479"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="738" mass="81993" checksum="B327AD9916C4A402" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE31</accession>
    <name>F9WE31_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_06340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06340"/>
    <dbReference type="OMA" id="MNSCNPI"/>
    <dbReference type="OrthoDB" id="871292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389025" evidence="3">
        <location>
            <begin position="20"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="647"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="4">
        <location>
            <begin position="501"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="746" mass="81788" checksum="D368A5670BA357E5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE65</accession>
    <name>F9WE65_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60570"/>
    <dbReference type="OrthoDB" id="1674039at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="40573" checksum="BF775E510B165690" modified="2011-10-19" version="1">MTAHPARSLQGKNKAPPPKKKKEARKQKTPIGKRPAARGGPSPKEVQKEPPPKVNWSGIKQFTTAMLRDVGVVLLEGMGDRENINLYDFLKPHHPDLDPDLSRFTLEDFFRSPHRRIPDRAQREAIQRHIPHLMKQLREDILKTIRYLGKHGIWRLEGLLWWKPRTPLKPIPQRILDDAIYWAYRLPSNAPPPRSEKHRILGHRRPPPPPSKKVWTMRSRLRDILKERCKTWEDVSLAEFLLEECAFRFEDQPRPKGSLHDFLQDPAQYLHHEEARERVLQEMPAKLEDLKGRVLRDGAFLHEKGLKVLGQWLDCLRLGESLTYATTRILNGVVNQIFDKPYEDTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI4</accession>
    <name>F9WEI4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_07080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002016">
        <property type="protein sequence ID" value="CCD15694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07080"/>
    <dbReference type="OMA" id="RMRARRH"/>
    <dbReference type="OrthoDB" id="848605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="325"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="326"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="39764" checksum="668F16E3AF3597CE" modified="2011-10-19" version="1">MLMEHAPITGILLGVSAYCSVVTPRSYLTARPLPTTPQGWTATVQHLPLLSVPFGSLGLSPFDIGCALLILLQMRTLERRWGSSSFLTFVVVTALLGSILTSFLVTQTTPPLSLEQLQVLSAAGSLVPLSSLVTRFTMELPSLHAWQLPFLPVAVTEKVTVILPLLRLVSLPETEGLLRIPRQRGSIVRVDVGLRVRLALVLAGVLFGLASSGSRPLARFLGLVSRRISNPLLRLLRPFLDVVGGPSVTVTQTLPKRGSTRQFVAGGRYALDNLSGIGADGDDFQYPLHGTAIHRRNGIPRQRGEEYHRRQSQPRNQWQADGGDVVPDELIAQVMELGMGFDVDTIRAALIASNGRPDVAINMLVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER1</accession>
    <name>F9WER1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 304</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002053">
        <property type="protein sequence ID" value="CCD15777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07880"/>
    <dbReference type="OrthoDB" id="1763845at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394719" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="18819" checksum="0EBBA289A518EFDC" modified="2011-10-19" version="1">MRARTSALLISALSSISALFPHVPASFAKDAPLLTGGLLQWGPHVACLVAPFLDLPHLTHPIPAAHTLQFPLEHGKPHVPATLSSHLLLSAAASSAASSAAMHGGSSGSAAPPCLPIRCRSLLAHALSSHLHTRHANSPLAFGPRPLEDRGCPSPPPPPQLTSLSALGVSLATAISTTGTPQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF13</accession>
    <name>F9WF13_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08730"/>
    <dbReference type="OMA" id="NRPIHRG"/>
    <dbReference type="OrthoDB" id="373502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2067" mass="224579" checksum="DDA3185246C1FFC6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF34</accession>
    <name>F9WF34_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002097">
        <property type="protein sequence ID" value="CCD15902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08940"/>
    <dbReference type="OrthoDB" id="1702466at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="21703" checksum="E8F2B10DEE710183" modified="2011-10-19" version="1">MCWFRLFCSQGTSSGDVATDIIDRDPRWLHGIMFLLGSAKNINQSHVSGVIIEARENMRMVKEQMDNEVCEMERFLENLGDLHGFSEWKNSWRVVTQAVKFGTVSMFDVAEEEVERCLCEQKETTKAIQVAVCGLRESFEASRSDDDFGSIGFSIGAAAPSDNKISDNGFTACVDISGYVKHYKCLGVHSRRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF70</accession>
    <name>F9WF70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 354</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09240"/>
    <dbReference type="OrthoDB" id="1710997at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18811" checksum="C6C72DC6315EA8B1" modified="2011-10-19" version="1">MSCGVLGYFKQCQCYEAKWGRRQALTRLSEKHEGVRANCCSLHDTRVPKIVKRLINVTCALSAVSHSIRDDGTAYTCALNRIFHASAPHCVAILWPDTLCTHKRESVLTNNHTWPHRRVFEMDLLFPLKFAWGQTVHKHDTFGSYWLPQYPHYFIGIPRPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH3</accession>
    <name>F9WFH3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 385</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_10130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002143">
        <property type="protein sequence ID" value="CCD16045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10130"/>
    <dbReference type="OrthoDB" id="1715618at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390291" evidence="9">
        <location>
            <begin position="27"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="13"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="211" mass="23618" checksum="299C176F3CC4FAC9" modified="2011-10-19" version="1">MLMEPRSMWWLFLATVLILRAEEALGTGPKAIRTKAGAAICTLSKTLKDVTPWATQQVEDGAAKITNLEMKLLEWQSKSIQSKSKGIGSETCKMTGFLFRQVRKEIDKARKEVEKLEKEASKAAAFAANSAGRLDEFITVFANARNESGISKYCFGNEKSATKDELKNLFIRKKFSEEYMVDFKEKSSERDPNLGAALEGIKYGTPKKNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM5</accession>
    <name>F9WFM5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002163">
        <property type="protein sequence ID" value="CCD16101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01310"/>
    <dbReference type="OrthoDB" id="1726562at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20892" checksum="12569110E0643117" modified="2011-10-19" version="1">MSGFLLPVRRLAHLFSSFDVSRVRCMYLARPAFSAPFPSFVLFSFSFCLMPSKCIFFSPSPLVCLSLCPTTLPFTYRRILHVCLWGSAGRVETETTERCMFFFFPFPFFSFLKKRKYFGCGAWRILYDVGAKMYGICVAQGCGVFIFLLCRALSAFFSIFFTSCVCVCVYESRSRVDQRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFR5</accession>
    <name>F9WFR5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002180">
        <property type="protein sequence ID" value="CCD16143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="106" mass="11776" checksum="1722C0000AC9C2EC" modified="2011-10-19" version="1">MRRIEKVGREIRSVAGKPDKRDTTHVASSMTLSEEKKLMGNVRDLRLNNTKKTICQVPFAPSLFLGLLGVARGSWIQHKRLSVRLSIAALSHSRAGAVTTRWPGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFR6</accession>
    <name>F9WFR6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002181">
        <property type="protein sequence ID" value="CCD16144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10950"/>
    <dbReference type="OMA" id="RYFVNLR"/>
    <dbReference type="OrthoDB" id="1418057at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="241" mass="27497" checksum="A80949D95D2CEB01" modified="2011-10-19" version="1">MNCRVNVIVSVRHGCTRRLQVWGLPTSPTVGATCGSCLCLPRFFGYSPFDSIRRPPKGHAGSQTSCSPTSTSSVGRAGDSDDHAHISSKPWKFPETLKSGRYKHDQQPKRRYEGPKAHGVGGPDRRFFRRVKDFREVQDDDPYASVFGERLSVKRQRIKEWQRQFEEENADVELPYERTNALARLAPNWFVRYFVNMRDRGGADPVFHIIILAVGLLMTLWIMGRLFYTPPSSARPISELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT2</accession>
    <name>F9WFT2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11110"/>
    <dbReference type="OrthoDB" id="1705040at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22303" checksum="0977F8F2318826D3" modified="2011-10-19" version="1">MVSPISIPFPIPRSRGQTGAPLRKALKPALLFGEAHEEAEPDDVPDFSLTHGAPGNLEYSGDSYTAHREYDQDPRKSIPITCAVCVHLWREGGRGHSLMTAGSMPCVVYEEGPRNWDEHRGECPSGREDPVWTASNTGKLAPGYGAATWKPVVLPTASGWEVDQDSQKARDTLPEALHWENDDTLHWAPGRDFCRSDDSGSAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFV5</accession>
    <name>F9WFV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_11340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11340"/>
    <dbReference type="OrthoDB" id="1676710at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
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        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389086" evidence="5">
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            <begin position="19"/>
            <end position="346"/>
        </location>
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        <location>
            <begin position="53"/>
            <end position="272"/>
        </location>
    </feature>
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            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
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            <begin position="259"/>
            <end position="321"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="277"/>
        </location>
    </feature>
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            <begin position="278"/>
            <end position="300"/>
        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD16185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38613" checksum="6F6F53280731DAA7" modified="2011-10-19" version="1">MKVLLFWTLVVGIGFSSSREEKDHNKDAHKALCDVLKAAVNKWGDGGATLAQPLKNALKLTLFGYGKSEENWDKLKGQVPEEYHKVDRSLLCGQPYFEGIRQSQPRWTGYSALHDLVCLCTLGDKGWPLNESSTGKEKLCGQPQETFGGSNRNGWRGSGTGKEQITATWTKATSECMEGRGKNLKEALKDFMRILVHQPGVGDGNTNKDLLGEGDFNSYPCSGNKKVCVMYYRSADNTNTKYPMPWWTELNAAIETNEAEKQKNKKEEEKRKIEEAQNNQKAQNQQASQPQQTPRVATVKSTIHEKQEDEQDNPENISSPIATIDETSGTLIIPPSSWLLSALLFI</sequence>
</entry>
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    </organism>
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        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
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    </dbReference>
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    </dbReference>
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            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="624" mass="68882" checksum="5E4914F54F85B48A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG72</accession>
    <name>F9WG72_TRYCI</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
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                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
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    </comment>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15421" checksum="B635C3397FBA0FF9" modified="2011-10-19" version="1">MFSRASCRAINTHWFAVARNFGPRNPHSETSCHVMGLQNRQRPLEIQLHQLSPTRSSIVQIKRLQGLQGLPASRIEFMVEPIDGFTRLLLHRTTREIKLFDEGAPESYPLTVARGGLTSIPRGTVPTGRFKFLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 491</fullName>
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
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                <person name="Hauser H."/>
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                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">IL3000</strain>
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    </reference>
    <comment type="caution">
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        <property type="protein sequence ID" value="CCD16367.1"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <location>
            <begin position="357"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1064" mass="115153" checksum="5EBDC2467D3CD5CF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGP8</accession>
    <name>F9WGP8_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 525</fullName>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD16485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14040"/>
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    <dbReference type="OrthoDB" id="977327at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cilium"/>
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        <property type="project" value="UniProt"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="821"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="385"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="684"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD16485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="939" mass="105797" checksum="7656356E14E1E53F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
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    <name>F9WGV4_TRYCI</name>
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        </submittedName>
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    </gene>
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            <taxon>Metakinetoplastina</taxon>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1669751at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
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        <property type="entry name" value="NlpB/DapX"/>
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    <dbReference type="Pfam" id="PF06804">
        <property type="entry name" value="Lipoprotein_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="371" mass="40492" checksum="60CEE639AA3F90AC" modified="2011-10-19" version="1">MKRLAGLSALALIISSTSGCGWVWGPEGYFRDRGSDYLEAQATKPMQLPPDVNVAKRLDPLLPIPRNVADDTVKGEYVVPRPQPIMAVADASDYSLQKSGDNRWIVAQRPPAEVWPVAVQFFQDNGFRLDQQRPQTGEFTTAWQQGRELSANMAQRLLAGGVAADSEARVRVRIEPGVQRNTSEVYVVSAERPAGSTADVDFTPRSVNTGVDAALVDEMLASMSRISEKGGSVSLLAARDYDTPSRVSLTEDGSGNVVLNLGEDLDRAWASVGRALEQGPWRVEDINRSLGLYYINVAEKAEKKDDEPGFFGKLFGSAPTKEEIETRAERYQVRLSKVGESVQVTVEKNINTVAPAETARKVLGVIQDNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGX4</accession>
    <name>F9WGX4_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 567</fullName>
        </submittedName>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="OrthoDB" id="533939at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="ANL_N_sf"/>
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        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="653" mass="72614" checksum="5B30347E76DC9887" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY7</accession>
    <name>F9WGY7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 57</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">TCIL3000_0_01690</name>
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    <organism evidence="1 2">
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            <taxon>Trypanosomatida</taxon>
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002353">
        <property type="protein sequence ID" value="CCD16576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01690"/>
    <dbReference type="OMA" id="NTENHIG"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="877" mass="97836" checksum="3BB40CF5D2B33DFE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHP1</accession>
    <name>F9WHP1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 677</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002467">
        <property type="protein sequence ID" value="CCD16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17250"/>
    <dbReference type="OrthoDB" id="1739767at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17023" checksum="AB9F27748B51E8FA" modified="2011-10-19" version="1">MHDLQGVVLDFPFRLAVPCLKMHCGETLLPFTLHWPMPTLECVVHREGDHQKLILHLSCGMRAYASQAVIIACMRCRILHTQSIFLSPLPCAGLFFDVSSASPHPHSPLPPAHPSRFRFLLILLFFFIWEGWDHGGSQWPTPWSGCFSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHQ0</accession>
    <name>F9WHQ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002472">
        <property type="protein sequence ID" value="CCD16844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11304" checksum="AA031B1D980D9ABA" modified="2011-10-19" version="1">MRPLLAGFVVESRAYFLAAGSSTYSPISTPVRVVRPDRTDVPIPCLDEINAVAPFSRKNSRGRASSPDPSRVYNAGYNTLHLLNRCLFEWRRISKLLCHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR7</accession>
    <name>F9WHR7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 688</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002479">
        <property type="protein sequence ID" value="CCD16861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17460"/>
    <dbReference type="OrthoDB" id="1297837at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="53094" checksum="27FBF93BAA4B60B1" modified="2011-10-19" version="1">MHLDFGIYGDVLAGGWPGDRRNWPCRNASDRSKNPYLSQENILIFLIFGLVLSPAIQFFFLAFCNFHDHNVRFCNEKARCPCEFSEAARFVFTYGLHMYIPYAVFNPMLFFLALHVITQEREQQRLLCRIRCYITTDNIGQTNADDAAGQHRALWWDVPPVVQALYSNFPFWTTVVMRFVLLATLETWVIKLPGEDAKRAILLTLALSVPLLVTARYTGELSLIVPFVLLDAYPLLIPSIIASTGVGKEMRHALHPLLLGLVERLFWYLSAAAMPQGTPVGIKVAVSSTFAFVYVVSALISTMFIAGKQWLLVLVISAAQIFLFEMLFNLLVLEVLVLQFFRCIVTRMKHGEPSPVAIEVTDPINISTQVRWPAMLLAVCAALPLFFVTRWDRVLPRGQCDGYVPRREHSLLAPLVSCAAAFAMACVLAAVIRLRYDRLRPPLVVHDWFLTLMWGWFIVCSVPFALTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHX7</accession>
    <name>F9WHX7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002495">
        <property type="protein sequence ID" value="CCD16922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18050"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20210" checksum="5A726063B3EA4B71" modified="2011-10-19" version="1">MSESPSSPSPEGMARENTPWSMEKDVVEVLLHGIGKPEGINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDVMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHFQEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI12</accession>
    <name>F9WI12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 718</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002512">
        <property type="protein sequence ID" value="CCD16957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18370"/>
    <dbReference type="OMA" id="AISEMHA"/>
    <dbReference type="OrthoDB" id="1657053at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="753" mass="86849" checksum="D389ED6A2818883A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI50</accession>
    <name>F9WI50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_18640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002528">
        <property type="protein sequence ID" value="CCD16995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18640"/>
    <dbReference type="OrthoDB" id="1666862at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="74"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="358" mass="40665" checksum="CCF71A3262A91DC1" modified="2011-10-19" version="1">MEVSWVFLFKDCFSVFIVKERDGMRTMFWIIVCFGIFGVFAQDGVTNHNEHAHKALCDVLRAAVSKWVTVKDSESPLKPALVKTIFGNRGDSKITPIELPIPEDYTKPVENDIQNTRKKLCGLCENKGQKHYPGDSAPHDLVCLCTPGQTAWPIKSGGRQKLCGEPQSAWESVDNVEKGWFTGWSDTDKGKKYINKTWTRIAKKCLENGDGHDLGKALEHFKNELWKNNKYLGKEALDCDGMYGSGVCVKYPSNCETKTWWHELEEAIPKHKEWEARQNLAAEKENQLKAPNGPQTAPQKRTQSRQPTPRSVSMSPQNEESQEQPRAEQVISNMNATIEEDSSTIIYPFWLLLVLLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIM1</accession>
    <name>F9WIM1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 813</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002617">
        <property type="protein sequence ID" value="CCD17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="DERKYHN"/>
    <dbReference type="OrthoDB" id="1654509at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="893" mass="100751" checksum="C59D55B3F36ED60F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS7</accession>
    <name>F9WIS7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 826</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002632">
        <property type="protein sequence ID" value="CCD17225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20610"/>
    <dbReference type="OrthoDB" id="1654995at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="776" mass="87662" checksum="148BBE7BE023DB02" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY8</accession>
    <name>F9WIY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 849</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002658">
        <property type="protein sequence ID" value="CCD17289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21190"/>
    <dbReference type="OrthoDB" id="1704724at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20645" checksum="F05F48A25ADD4805" modified="2011-10-19" version="1">MENTHTHSRRRRGSFVQEIAWPMMSDVGVVLPEGFVDPENINPLEFLESSHTALKQDLTRFNLGDLFRNPHWCILERVLREEIQRNIPNIMRKFREKMFITIWNPGAHDFWTLEEWAWWQSSDPLEAIPQSILDKAAQSAYWAPDPPTTKGLLFPPTATTGMDSVDPGPRCVQGGVYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ47</accession>
    <name>F9WJ47_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 872</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002683">
        <property type="protein sequence ID" value="CCD17350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21760"/>
    <dbReference type="OrthoDB" id="1757729at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18507" checksum="11F835BEE77FBC28" modified="2011-10-19" version="1">MFPWNNGVVGFSFALAIPFFDLFNHFFLFIFNFASLHANSYGAAAADNDIYIYVYIYIHIPMHIFCYYLDFYVAECFVCFSSPLSFVVLSFPLCGVKRRYSSKQPSPISVVPMKRAANFAIVDLNCTSYNNNNYSFLKFPVSTVVSLYSLHVVWEGGIVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ61</accession>
    <name>F9WJ61_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 875</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21900</name>
        <name evidence="3" type="ORF">TCIL3000_BAC13H6_002</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <title>Alternative modes of VSG evolution in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2011-08" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aslett M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="4">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CAEQ01002686">
        <property type="protein sequence ID" value="CCD17364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE578911">
        <property type="protein sequence ID" value="CCD21834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21900"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_BAC13H6_002"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD21834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="300" mass="33644" checksum="88CFF0DF40983ACE" modified="2011-10-19" version="1">MIPSAYFPRNTDVSREAPDTLVGATGSMVIGADVNSHHVLWDPLRPSDNKGEYIVDWCVQNNRRIANTGLATRRQRGTVALSSPDTTLCRDCEVSNWKSALTPYSDHHWIPFDVFVGVSLDVTAPSKTARALYSWNKARWNEFRNLSDDFIFRGMKRSAKCVCALSEAIATGVRMAAKRTIPKGKGVALLFWKDEVTKLDKMAQECRNERKRDARIRWRRKVLVDTAMGRWKENVSKLSTMDTASCNLVKSIYAPRPLTSPALMVVVVDGHPLTKRQQAQALANMHMARSTNGLARVGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ74</accession>
    <name>F9WJ74_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_22010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002693">
        <property type="protein sequence ID" value="CCD17378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22010"/>
    <dbReference type="OMA" id="GVYTAVH"/>
    <dbReference type="OrthoDB" id="1040292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="PTHR11932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="SSF74788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="SSF75632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CULLIN_2" evidence="4">
        <location>
            <begin position="431"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="814" mass="92352" checksum="D02083E04606179A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ78</accession>
    <name>F9WJ78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 881</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002693">
        <property type="protein sequence ID" value="CCD17382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22050"/>
    <dbReference type="OrthoDB" id="1048300at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="252" mass="28413" checksum="356D8AF1ABEB60A5" modified="2011-10-19" version="1">MARKREHCSSFAFIFQINFRVTWNGRRLYCGLGAFIAGKMHRMCTFRATSCMRWTPLMVPCCIRRWNSFAAGATGAGPADSEAAGSPDMSAVMERAAEARKEIHELWLSMEEMGDRQGRLQQVKELVEKYKLVPSTPREEDVSRGLGDAYDRLLLLCLPLGKAGAHGTDVLESLMHLAGRNGRELSVRTIQHLFSWADSFAEALAVFFSMRRCHVAMNMEAYYAMLYSLQRLEEEGWAHHSHDEAKESGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB9</accession>
    <name>F9WJB9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 895</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002708">
        <property type="protein sequence ID" value="CCD17423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22440"/>
    <dbReference type="OMA" id="IWEVTGK"/>
    <dbReference type="OrthoDB" id="1528609at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="287" mass="32254" checksum="D4D39BA18B2BD3A6" modified="2011-10-19" version="1">MPSKKAKIKRGKTKTTDGVAADESYFQWLDENYYVGKTQRTLAEDVQRKKISVAIKAFTRAQSLFWEMQLLDPTNPLLSAGVVPMVCVPSIIRSIGFNPTTNQLMQIGMLTIIGDNIMAKRPTEPVQRRLWEERQRDVLSQCMTATTISFDCCTFSADRMKVEAIGLELMQKGMFLFDPLKVSPIFVSLVASMTRTYVVLQKSDTEVMDNVFRALWATLSGHEDEEDKVKRIDIASLRHILVSYMEGPGEAEEEPPLTKAEVDVFINDVSTPLVDSIDEDTFALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP6</accession>
    <name>F9WJP6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 934</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002751">
        <property type="protein sequence ID" value="CCD17553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23670"/>
    <dbReference type="OMA" id="ECAIFIC"/>
    <dbReference type="OrthoDB" id="1378690at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34722" checksum="E77A67F01B780C58" modified="2011-10-19" version="1">MVRKIRYNRPKTSPPERLIDFLCSRFPYLTRRAWEEHIHDGYVTVVTAMVTSSGGGGPVHCGQLMPSDYELQQKDEVHFNPPRELEPEVDETVVTIYSDNVIVVCIKNGNLPVAEGGRYSLNTLVGLLQRKNLLTKVDGCGSGGGVSAANSRGDKGSDSTCAYFPVHRLDKETSGLVVLAKTQDAARFLSLLFERQTELLSAEVGKGMEAQCFDSPAVLSWFEGLLAMDKTVVKSYIALLQGEAPEGSCFVVTDRIGLLWDEVRENVTESEKHVKLKKLKMACYPSLPTKPQQHGRPACSRVRNPHHCAILGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR9</accession>
    <name>F9WJR9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_23880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002761">
        <property type="protein sequence ID" value="CCD17577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23880"/>
    <dbReference type="OrthoDB" id="1663989at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389231" evidence="5">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="128"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="46561" checksum="E984491F343C115E" modified="2011-10-19" version="1">MVCVMNVISIFVVLGSVVRGQVEVAKDDNIEHFALLCRIYNVAKNPPINHVDMKEGHYIVKEIDTLNKSLLEEERLYEKEDAGNFGDPSQTDRNGRNSTRPTQPQSNHPAGSHNYGGYYKKNVPNEIQEAKAEFAQVIFGENENESDLDQGALKEVTGRAHACGDSGLTTRGNSAGKNLVVDFFCLCAQRQDGQGAKQVCGFYVGRIYENGLLGWNESHPIGSATMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLKTGGVYRWGAGDKVEGSERREGMLGTGVGKNENSGNGPVCNGKKGGKPPSSPGGVCIYYGPKSDNWEEKIEWMKKFKTALASVDYVNNKTANIQRSTRKLQMLLQRAEEIYETAKVISEVQNPVGLPAAFQNTSGNLTTYNATRTRSYSPYPHFMPLWALLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK04</accession>
    <name>F9WK04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15276" checksum="D12B03633FAF0C8C" modified="2011-10-19" version="1">MLGYFPVFLKTAGGSDRNAYPVFAFSGTIVGRPACNGKAPSRDRFLPSLLETTGVLLAVAQRGMGRPACRVTIDYPFSYRRRKMLFSVCLAFLYFFLFVPSRVSDRTAPMAKPPVSINPRFILFDFSMGNSLRGFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK19</accession>
    <name>F9WK19_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15616" checksum="59328EFB0910807A" modified="2011-10-19" version="1">MHKTMKMTVTTQMKKKWIFFFLKGKKGTENKDTCRYNHKTDRKEHPLQQLQVQKDAHNQALVSCSTHAVRILVVIARPSIPLLSLLLRQTGSLRQRKMWEAADTPPLPDHVCTRALRDNKTNQFLIFLLILLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3K3</accession>
    <name>F9W3K3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GARP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_26750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000427">
        <property type="protein sequence ID" value="CCD11722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1660683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389844" description="GARP domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="3">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16081" checksum="17DC131D1E4D71DD" modified="2011-10-19" version="1">MHRFFYFAGVVLLWAACLPGSGDKLSLDQVNAFCELTKQFRHLPIAVGQQLDEAIDEEAKAAKARKDSQKAVNRADAAAKKSEDAKKHAQDAKEAAKEAFEAADGAEVHLQAASELATELNGLVETHLSRLENILKDAENDGEDEHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4C1</accession>
    <name>F9W4C1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 116</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000539">
        <property type="protein sequence ID" value="CCD12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03050"/>
    <dbReference type="OrthoDB" id="1180234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="202" mass="23418" checksum="74AB17566AAC8C66" modified="2011-10-19" version="1">MRTDPLLVNGRVIFPLAHPLLHVWYALHRQAIVAAANNAQALLQMQSTAVISSNSTEAATGWRSRELSANELRRRQMQAQRRCERALRMLRRISGWAILPLTQAVEVESSDVLKEWMWFQSIRFKLLIRRVRLLRIVGTFDACNRALEETCEQLRLLRSQDEMLCRSVEVQRLMDDVFNQITREKLLLRDEGAQKGGLVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4H8</accession>
    <name>F9W4H8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_29890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000556">
        <property type="protein sequence ID" value="CCD12070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="915621at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="26783" checksum="EF59CDB3BB7DDEEE" modified="2011-10-19" version="1" fragment="single">MEECDINLEDALAAAVEAAQKAGAIMWDFYQYRRQVSAAEALEKGKGFDSNDEAVSGGEGEKPSVSQLLDTKVKSCSTDLVTEYDRHCDEAIMSILQQYSTTVERQKHKSGSESFHFSFITEEIHPDMRLTDAPTWIVDPIDGTMSFVHGSCDCCVSIGLTIKKETVLAVIYCPFIHTTNCELTGFLSSGLQKGELYTAIRGKGAFLNGHPIHVRSDITQEEAIANFGCPMRPVLSAAELEESGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4W4</accession>
    <name>F9W4W4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_31150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000623">
        <property type="protein sequence ID" value="CCD12211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="293"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="762"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1101"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1120" mass="124881" checksum="AC28AAC6542A9AF4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Y9</accession>
    <name>F9W4Y9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000632">
        <property type="protein sequence ID" value="CCD12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="111" mass="12538" checksum="56C8FA12912B913B" modified="2011-10-19" version="1">MAKITGVKDEKCNKYFEQPILQAFGREKPFYLMTAEHTIPYQWLLAPISSIRFSAVLKGGFGFYYDILSWIFRNSSVCCPEGVVRNPPGKGRLSVVRAAPEKTRTALKMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W545</accession>
    <name>F9W545_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31890"/>
    <dbReference type="OrthoDB" id="1673683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389896" evidence="2">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="38866" checksum="976427456918C4B2" modified="2011-10-19" version="1">MMTLKTVQVMLMVGFMVTGVKPDDEVVLNTSHFYLLCNLTKATTELWNTVAETEYFSDQEKAKLSKIIHEIFFGPNRPGLGSGMWELPDKFAQEIPKRNEFCISNSDSSLMPSPEESLASTFICLCTGIEGNGKNLCGLEVNGKDEWPDGDPVHDANTVFKNVWGDYQNGGVIKLCGDTSSFGEEQAIQNLKANITNIEKTLKVSSQDKKCILKDGEPCTKVKKSTTWLKLLTSIKLPPKLAQETIAEISVVKHTSELEPDSSHATGAESAPSPGPGPQTEPEPLSPKTPVVIHKQEARKAHPQQPEPEPEKAKNAPQKQTEKTEDPLPAPELNETSGSYLTSPKWPLWAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W587</accession>
    <name>F9W587_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000677">
        <property type="protein sequence ID" value="CCD12336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="112" mass="13661" checksum="BE5ABBE8820E30DE" modified="2011-10-19" version="1">MKIRDKQIPHNHFWNRKNFRPKSQKKIFFYKFFFENLQKLEKVFDTIFCKILKNHYARQKGPKTTNTCKIRVFRIFAFLTFLTIFKKTGFWPFGPKKVNFGKIAKCPFSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B6</accession>
    <name>F9W5B6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000690">
        <property type="protein sequence ID" value="CCD12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13541" checksum="5287E5BCAA6A5CB0" modified="2011-10-19" version="1">MYLFIFVYILVILYHCLFARYPLVYFFFYYRCDTVQHAAEHYPSLFPEANYCLVKGYVACCSSNSTVMTAAVLFIYLSIVVVLCCVVIICMFILLIVIILHAFIHVHVKYNAIVSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G6</accession>
    <name>F9W5G6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_32980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32980"/>
    <dbReference type="OMA" id="IQNVHEY"/>
    <dbReference type="OrthoDB" id="330091at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="529" mass="59474" checksum="2C722CA01BF72D16" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L0</accession>
    <name>F9W5L0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000727">
        <property type="protein sequence ID" value="CCD12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33410"/>
    <dbReference type="OrthoDB" id="1763057at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16205" checksum="0AA66C77EBE76907" modified="2011-10-19" version="1" fragment="single">FSTFFIECFLFGRVVCTGVVTVVPNLKWQQSLPPSARFFLDSQLIDALAAIRVPLASLLVISLPVFFLCCHAQRSARRKEAGLKASEAVISAAALALLPLQWPPQSLQPILNEKSEELEVGVTCVAVHDKTFKQRDGHASTRMKINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L4</accession>
    <name>F9W5L4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000727">
        <property type="protein sequence ID" value="CCD12466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33450"/>
    <dbReference type="OMA" id="CKCSAKR"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389902" evidence="1">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="39466" checksum="14280578594C4645" modified="2011-10-19" version="1" fragment="single">MRSVNCYALLALVVAGQCCGHMHATAAVGTTHQALLWGSKWALRNKTTPKDGEVWWSNPQPGWKEVYDDEWEEWFMEQKGPTGVNGVRTEWYRRMKDGYILVGGPKLNSPDMNSTGTTMRTVHSYRIPSIVEVGGVLMCVGDARYITSTDYFFTDTVAAYSTDGGRTWKTEVIIPNGRVDAHYSRVVDPTVVAKGNNIYVLVGRYNVTRGYWHNRNDKAAIADWEPFVYKGTVNVGTKGTATDVSISWERTALKSLYNFPVSGSPGTQFLGGAGGGVVTSNGTIVLPVQARNKANRVVSMILYSADDGKSWHFGKGEAGVGTSEAALTEWDGKLLISTRSDGGQGYRMIFESSDLGATWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5P8</accession>
    <name>F9W5P8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000746">
        <property type="protein sequence ID" value="CCD12500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="14593" checksum="FE6D99CDFA48867E" modified="2011-10-19" version="1">MVGLVCKSTGGGSTCPAPGERGEPPALLGTLFDEGQPLGVILECSAEPGPDATTFGARIVSQNNGSSYLGMGSVQTSSAPASGGVRSASSGSCCGGGSDSAECGGPTTRVYVSAAAPSEVVCTGTTTPNAAPCGGIFGEFEWAKTVWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R2</accession>
    <name>F9W5R2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000753">
        <property type="protein sequence ID" value="CCD12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1083706at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16262" checksum="BD0EA9EE47A93662" modified="2011-10-19" version="1">MGNDKKKGGGKQQHNHNAVSAESLKNMERQVALLMKEKLRLQMVLQLNEEELQPKLTEIKEESEVLVSKLNASDNTTKGTTGGPAAQQKQITSRMAELTQKQTKLTMERNRLALQFKTQVTPLREELLALLKQRDEVQVKIDIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R9</accession>
    <name>F9W5R9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000756">
        <property type="protein sequence ID" value="CCD12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33940"/>
    <dbReference type="OrthoDB" id="1654850at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="766" mass="86677" checksum="5B37CC4A34720B7F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W640</accession>
    <name>F9W640_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000820">
        <property type="protein sequence ID" value="CCD12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35040"/>
    <dbReference type="OrthoDB" id="1733340at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17033" checksum="317560B74A753A0C" modified="2011-10-19" version="1">MVSSRFAFIAPSAICSCAFTLSCKFHNKVVGSFFPLASNILPGACSIPTDSTSNQTDKYPSSSSHKYRPYSSRISTPSTRAHPFRYAPHSQLPVKLLLPMEGSPMRLDKRCVSAMKRSILCSRFPSNLLDIRPSHPNGRTYYHREAACHPSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6B8</accession>
    <name>F9W6B8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000847">
        <property type="protein sequence ID" value="CCD12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35800"/>
    <dbReference type="OMA" id="VENSTHA"/>
    <dbReference type="OrthoDB" id="29964at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027912">
        <property type="entry name" value="CFAP54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14858">
        <property type="entry name" value="CFAP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1786"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2700"/>
            <end position="2730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2895"/>
            <end position="2914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3397"/>
            <end position="3426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1895"/>
            <end position="1911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2715"/>
            <end position="2730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="3885" mass="425559" checksum="3C921E370EA9CAD8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6F3</accession>
    <name>F9W6F3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1456</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_36120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000858">
        <property type="protein sequence ID" value="CCD12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36120"/>
    <dbReference type="OrthoDB" id="33214at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="SSF81837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="4">
        <location>
            <begin position="1237"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1884"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1276"/>
            <end position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2072" mass="230386" checksum="571830073AA3DAAD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J1</accession>
    <name>F9W6J1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_03640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000883">
        <property type="protein sequence ID" value="CCD12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03640"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389860" evidence="6">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="38"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="357" mass="39533" checksum="7C378C637C5BA9BF" modified="2011-10-19" version="1">MWCRNVLLVLTFLHFDTITGEYNITKHHRLLCDVFEKAQKVLRLYGGNGNMTDSLKDAIYGTKSTALFEQGGKVIVNEECNKNSNGRDDFCKFHKGISYGRGCFAGSLVGTLMCLCTPGSNDAINVCGVAASQYGQKWVGSEKRSEQNAHLFQKVWEKVVRDCHGKNEDGKNSEEVLANLEKAAKAVQEKLEQRNVTSTDNSIYFYLGGDSKVTHCIGINGGDNYLNHAANGLCVQYQGEASTKNATIPWVEKIEETIKKLKGVKPVPVAYSVTYEKNGLSSGHSKGASDGFYYNTERGSEKHRPDHSTSRSEGGKRSALEFLEGYDYNKNGFEFVPLTSGSKTIMPLWLLFVTVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z1</accession>
    <name>F9W6Z1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000952">
        <property type="protein sequence ID" value="CCD12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37700"/>
    <dbReference type="OrthoDB" id="1710735at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21018" checksum="2079455EFF1621BD" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVEVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEANVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDNDDTPLEAIDEEIWRRCRRPPPPPYQPCQGVVLVEATASFIQVPYSTVGYLVQLPVTPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z8</accession>
    <name>F9W6Z8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1541</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000954">
        <property type="protein sequence ID" value="CCD12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37750"/>
    <dbReference type="OMA" id="CYESEDR"/>
    <dbReference type="OrthoDB" id="554921at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="573" mass="64102" checksum="68422CDD368C95F6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W703</accession>
    <name>F9W703_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1544</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000957">
        <property type="protein sequence ID" value="CCD12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37800"/>
    <dbReference type="OMA" id="WSIKQEA"/>
    <dbReference type="OrthoDB" id="11968at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009367">
        <property type="entry name" value="Elm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33986">
        <property type="entry name" value="PTHR33986"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1901" mass="219513" checksum="0405D9B0A42F1BD9" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9W769</accession>
    <name>F9W769_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 1575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_38500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38500"/>
    <dbReference type="OMA" id="HYIAPDI"/>
    <dbReference type="OrthoDB" id="831082at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="PTHR12560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="125"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="45897" checksum="02FA7AB126641D40" modified="2011-10-19" version="1">MALHPRGELYAMGPERAREYGFVSYYNHTGNETLDRLTNNITLTTEEWLQLVTSPVQFILKSGGWGGLGIDATVLSQLFPCLLWTIVFAGLRFFAQKQLSRLGLWLQVVVPRHGDKNNMTTSQRLKLKKFQNQLWLTVYYTASTIFGYVILRDKPWFGLPVSESNRIALLTPHPYKPEVELLRYYRYGLGFYIAEMAALVVEIDIKRSDFFEYFIHHVVTLLLIIISHCSYEHRFGVYVLFIHDASDILLALGKVINYVVKGDGNRMRNRKAGKSKNAAANAPVSRLYKAIFNDSMLTACFLMFTVLFFFFRLLCLPFLALANIVYGVKIRMFTWSFTFLIFLLQVALQGLHVYWFTLILKIIASTITGKSVEDIRSEDDDDDDDGGGEALPKKSKRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7E4</accession>
    <name>F9W7E4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001012">
        <property type="protein sequence ID" value="CCD13110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38950"/>
    <dbReference type="OrthoDB" id="1732272at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="20365" checksum="809C405A0BBE666B" modified="2011-10-19" version="1">MYLSILPFFQYSHTHTQGSCGQLRGWRQRKREKRVARHTHIKYHPVVRWLAPAPNPTRRAATATRKGISRAPFHKFIVLSLVFCYLSSPSFAFSFAWYFHVYFYFHLFPHLLHISTIIHCLHLEKHLGQRGRKCTVGDIYRTTLLEVTAQFSSHPFYLFPFHFRFFHPSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7J4</accession>
    <name>F9W7J4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1620</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001042">
        <property type="protein sequence ID" value="CCD13161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39400"/>
    <dbReference type="OrthoDB" id="1713695at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="20036" checksum="395F3D63947E512C" modified="2011-10-19" version="1">MENIILGYTKDCMAHDNSAHQARISIESRLTSSIPTNELPLQKRKVTYLVEAPHHQRFGPRRHPLNAVSKHDIGRSLLVVHPLPGCFKSPSHPIALLHSPIRAYRMKKNIIILTTVAVVTIVYEPSLTDCGSHRSTIMLFFPWEMKQALCCCRPSAWEIHWCHSSYYIGNGSTPPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7R7</accession>
    <name>F9W7R7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1646</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001071">
        <property type="protein sequence ID" value="CCD13239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40080"/>
    <dbReference type="OMA" id="ISMHTNF"/>
    <dbReference type="OrthoDB" id="1293706at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="294" mass="31434" checksum="5B522E20756270A2" modified="2011-10-19" version="1">MKVPLSSRGSMSSLITRVANAMGEIAPLHLAERSWDNVGILVESPASNNSGVVVLTIDLTPEVMEECLRQNAEVIVAYHPPIFSSFKRLSLADPKQKMVLQTIRHGASIYSPHTALDAAVGGINDWLASIVDGTGRCHPIRASEYAAKDDNSPNSILSYSAAGVGRVVLMNEPKTMEALVQDIKQGLGLPTVRVSLPSGWTERKIVQRVAICAGSGGSVFSLLKESVDVLLSGEMGHHDVLAANAMGQAVVLCEHSNTERGYLSRVLLHKLQQALGDGVQVVVSTADKEPLVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W8</accession>
    <name>F9W7W8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1666</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001093">
        <property type="protein sequence ID" value="CCD13290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40580"/>
    <dbReference type="OrthoDB" id="115159at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="PTHR11289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCA-2_OB1" evidence="1">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="764" mass="84437" checksum="6C22379EC8B94DC8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W824</accession>
    <name>F9W824_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001123">
        <property type="protein sequence ID" value="CCD13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41080"/>
    <dbReference type="OMA" id="PPRIYHY"/>
    <dbReference type="OrthoDB" id="1355024at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="285" mass="31609" checksum="5FD2A45F54E5F7F1" modified="2011-10-19" version="1">MRAGFRRGRLDKVQQPGAINSYTAALYPPRIYHYYTVPSNISIAGCTTIIGPSIDDGVGDSRGREILPESGGPVVGKTSPPALRDYMGCFVDVNQCIAEARAFDIVESGNEMLNILHYPCLLGVKTDEQAGTCTGVGPQSTSSGATQRIRLWEEVLSLPKELRCYSIVRSRDVTQAMIERLRIRPVKRKRLVKPMRRGAKVFVYSIGEETQDNLRGNKRVRDNDEQKGDGSVQQKRVDDEAREVNGDALCDKYDDEASLSYQVDDDDDDGDLDGPNESGDDCDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W846</accession>
    <name>F9W846_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1705</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001136">
        <property type="protein sequence ID" value="CCD13373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41300"/>
    <dbReference type="OrthoDB" id="127137at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="321" mass="35206" checksum="59F59B626A345864" modified="2011-10-19" version="1" fragment="single">MSGVHPVPVSPLKTSHPLNPFIPISSRVHVGHGGPASLQRLVAPSELLPEASTKYVAGDSNTNLQGRGRGMSASCPPVKGKANVYRDKGPVAEPERTLSSADSRGAVGSVNGLCHPREGAEGHVERSVTGAYRDFSSGSHAKHHIDTSGASHLSMKQLSVSILGMSPLHANPFVVRPFVRVWLVDGISGRSLTTMKLAHTPCCVTHPVDIRFRHTRAPWWDAEVLFPVAPFVMEDSSLEPLLLFEVLDDASEKIDGFPLRHKDFYRICWGFLRLRGTKGKPIFGKRLNIQMFPFPERVSFFTRILQSLPSFFLQPYGGSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W884</accession>
    <name>F9W884_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1716</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001149">
        <property type="protein sequence ID" value="CCD13414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41640"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394767" evidence="5">
        <location>
            <begin position="23"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="45"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="254"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="38464" checksum="D179D0837781F2F3" modified="2011-10-19" version="1">MRFTFVIDVILLEVIVIEMSHSEANYNEGSHTLLCAVLTAAVDKYKEVRSKGSAIEKALEKTIFGNTAAAQKTNEYPMPDDYNPHGKVENKEPNTRKDWCGTCGNRDQKHYPGESASHDMVCLCAPGQHGWPISGTDGKKLCGQAKDDWTKDGSPGWYTMMWGETGHQREHLNKTWDKIIRNCLRGGHAKNLEEALDKFIDKLEKIDDNQYLGNRSEGSDCSGTAYGGVCVKYTPDCIQNSWWNHLNEAIKKDKEERGKDAEQTKSEAAGKKNIEASDGFKKVPEQPKKVTQHTVTVLQPLKNEEKYNPQIAEKLLSNITVTEEKDGSPIIKPQWLLLTALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W891</accession>
    <name>F9W891_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41720</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41720"/>
    <dbReference type="OrthoDB" id="1665523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394768" evidence="5">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="79"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43453" checksum="2DC15AF63C99AC79" modified="2011-10-19" version="1">MMKLFMVCLVVTGGLVREGRVKAQGGLTVSQDDNSQYFALLCKIYNVAQYPPIKPVDTKEYQKIVDDINALSAAANGKERVNTQSEETKSAQTELTGVTHEARKLLNEIKKINPEGQAEGARHAFNQVIFGEHGKEGDLYHGTLEAKQQRMAACGSKNKKGTSAGKNLIVDLFCLCANHDVAEGVDRVCGVSVGDGKDSGWGTNLYPKATMWDELKDGCKNVATHSATSTQDGYSLYDDFLVKVKAGGTVKIKDSTTVQIHGMLGTAVSKKEKNNFNCNGKKEVSTIRVDVAGVCVFYGTHHLEENIDWLKKFKNGLNIIDKLNTETASWQHQLTTLLNRARELYEKVKADTQLEEESTDDSPLAQHPNSDENENADSTTQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F2</accession>
    <name>F9W8F2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001166">
        <property type="protein sequence ID" value="CCD13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04470"/>
    <dbReference type="OrthoDB" id="1132270at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="PTHR12963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04266">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="110"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="249" mass="27800" checksum="2DB75A81A86C2E4F" modified="2011-10-19" version="1">MPNSRNREGKPDIHRRVEVSRRVQQDYYEDDAQFFYDAQQNQIGGVEALPSAAVKIENIMDEDGSVVGSAAVGDSVTGAGGAIEGAVCGGILAPLVPTPVMRMNDGGVCLSMHQPWAGLLVAGIKVHEGRVWSTDYRGRLWIHAASSQPHDIEEVEKRYAKFSAPHQKFPKHYPTRVLLGYVYLMDCMDRETYERTYTPEQRQEESPFSFICAVGKALPFPLPMSGDHKLFRLNHKVHTAAKKQLMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8G9</accession>
    <name>F9W8G9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_42470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42470"/>
    <dbReference type="OMA" id="AFPYKHF"/>
    <dbReference type="OrthoDB" id="1266853at2759"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="6">
        <location>
            <begin position="240"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="50526" checksum="087D3FC0FE68D8C8" modified="2011-10-19" version="1">MLLERHSHLLGGIITMLLLVSRILDYGRPKGYAAKCMNTTAAGGAGWMDDAFGGDSQGAHKVESHPDGWLSTLRSPQLARRAICFLSSYTWGELFLTYLILQLIFLNLLLLVENIRDLIFRAPRVLKLGNSYLTAKPTRVDRKTALSYDTPWCLYERLKMVFFVFTGLIVLRLLILVVFATTSLAMMSVCGLGGRNRYDNPVWFRVFSTLAYTAFCIASTGVGFYNFKVFGRFASREECKVLIGNHSCIYEVCLLFALTDYPAFVTRKGNKLPFFTSVERVSEAIQVDREAVESRRRAAEALRARAKNKNPNAPQLIVFPEGTTANQRALFMFRKGAMEPGEPLQMICVSFPYKYFNPCWNGRCCGGNNFFELLFRLCIQFVNRVEVRALPVYTPTEEERNDPTIYANHCQEMMANVLRCGISNCTYADYVALQKGSQDPLSEGVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q1</accession>
    <name>F9W8Q1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_43280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001195">
        <property type="protein sequence ID" value="CCD13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43280"/>
    <dbReference type="OrthoDB" id="1667863at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390016" evidence="5">
        <location>
            <begin position="18"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="41"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="303" mass="33266" checksum="6DE7BECF78E7886B" modified="2011-10-19" version="1">MIKIWIMVMMTMGVAGATDHNGPQYTALCELLTRAAYMWEKKRGNLSKPLEKALERTIFGKDGGGTVEDLRKNKLPSGYSGTERGNLCGNPFDSVTDKQWSLHSPGYSGPHDMLCLCTPGENGWPLNNQVSGADTLCGQDIKTWGEDGSMGWASGGYEDEENQLTATWTNITLPCLKGGDGAGDLKSALKKFKRKLGEPVQKDPPYEPLGEGNFNDNFPCTGYSDKGVCVAYYNNTDPKPWWIQLEAAIQEDEKTKLDEEKRKLQKQSSVKEADLTSPTNATRSWGKTTNITNIKSGSAIPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8U7</accession>
    <name>F9W8U7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1781</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001220">
        <property type="protein sequence ID" value="CCD13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43710"/>
    <dbReference type="OrthoDB" id="1728747at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="17960" checksum="05A5AF715591EBAA" modified="2011-10-19" version="1" fragment="single">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGESPMSSARARRLFANWETCLRAAGGGQAGRHGEGSRGFRDQTGYTHNRARECQACHGKGRKFMFQLRRSCCVRLNGVCVQAKNSLIHSICGVPVVEIAVAKDTPSALRNVSCGGGGGLGHPRSSEGRGPNARGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8V7</accession>
    <name>F9W8V7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1785</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001225">
        <property type="protein sequence ID" value="CCD13643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43810"/>
    <dbReference type="OMA" id="RWITEQQ"/>
    <dbReference type="OrthoDB" id="1480289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="28379" checksum="795417FA70366173" modified="2011-10-19" version="1">MTVASSRVPVCAVTGRRFSPELEKELITYGGVMGFKSHYWVSEVQRCCRWLCLRDVGDVPFCPTTTFHRKGVLHLMNTVFMEETDLFLFFMLRPLPTRKLSASTHWLFVDCKWEALHERHGKYSQLAGLMGQVNCSLRNGRASLLPSVAESQRGTGCAGNGAATASDFVESGEIHGAAGRTRVQHLISPPSVATFRQADYFWVCQSNVFSHRLALTSNAVWSPLFSERVHCDCMYNMDQIKGITGCLRSLNFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W926</accession>
    <name>F9W926_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_04720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15665" checksum="1E6898361F7DDEE2" modified="2011-10-19" version="1">MSSGGHPNDSPVRMRENRGDGKQLPSFFYAVGGKGLQGGHMMVEIQLSSTFMSSSILIIFSCVRILRDTLLILFKMSSLICIWEHFPLEEILEKIRHFFGSHGLWEFVNYRCYFTTGNCVKYVYRFSVLVGGLSVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W969</accession>
    <name>F9W969_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001274">
        <property type="protein sequence ID" value="CCD13759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15866" checksum="6BEBB349A0A47447" modified="2011-10-19" version="1">MKSALVLPLFSNEVCHLKEDHSHMHLLLLLQYCYYFPLCLSRTYDCFPFFFLTVWPTVVQRPANKEDNKNSGDRAVCDKRVSIFQKLLKLGEAFWRGICNRQNSDDGINGVQGLTLHPPPLVLGRCNTLHSTAQIRAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9C2</accession>
    <name>F9W9C2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_45180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001293">
        <property type="protein sequence ID" value="CCD13822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45180"/>
    <dbReference type="OrthoDB" id="1664265at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394789" evidence="4">
        <location>
            <begin position="24"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="13"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="415" mass="45824" checksum="A3DE86617FDF6A7C" modified="2011-10-19" version="1">MTLKNGAVLEILSLFCLVHAAASKMKEGSNAKQYGILCDIYNVAANPPTSLYDTNYIEKIRSEIDIINASLSDDSSFSETADSEFHQNMSMGLKEQTKERASLLTRWMIAVASVDTNSTGFKKLTSTNLFVKRAQMKLIKIVKQAEKIIKSIEAEGSATFLEEIKKDFGDAVGEIGDQTKKADRATECGPGNLSGPGSKAGKFLIMDFLCLCSKPCISDYLPSVCGPDLKDIRWDKTSRSGEGKSDEKGEKTWKILQEGCESRPKPTRADPVAGYAALGEFLTAISQDAGISDKNKTGLLGSIQKDRGTNVVAGGCSGRNKAGHGTCLFYGDGWRDGGNNIPWVQKFRSGLKKLERIQKRDAFIQRLIGHLEMIQIRAEEIYEDAKMTLDYEDTEKTTQSHCRHTRFFLPWVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9J7</accession>
    <name>F9W9J7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001319">
        <property type="protein sequence ID" value="CCD13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="110" mass="11962" checksum="C2AAAD48BA5E23DC" modified="2011-10-19" version="1">MVVSTVMGRNPINTAFVVAKPQKPKLGATLEKRQVHAELQKANSLKRMGERGCQTVAPLSEAALRDIKGEAAGYLPQSFACNQFFIGMRRSNTEAEQRLAGTTDATAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9L7</accession>
    <name>F9W9L7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1873</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001323">
        <property type="protein sequence ID" value="CCD13919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46050"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="36803" checksum="1337588C7253C55E" modified="2011-10-19" version="1" fragment="single">MISSASQPKKRGGTQTGSKESSQTQKKPRHEKSDTSIFSGNSLHQTPDAQLLQRLVKCSRALRDAQPSFKVSADFVKEILSPRYLKSSLAGVQQMTGCLLSEITRRQINNDATNVGGPLLLDAKYADDVLDCLVAPFKEAVSCRKSLKTCEHIMDYASTSRIFFHVIPRCVKPLEERLTELFASVSCASGRPRSAGHVPENSRALTSASTAEMAKILQDVLRATGSITGGQLAPLLEEIAAASPALQRRIEACRARGSKHDATAAATDNSPGKTAGAVIAGRVLLEHLSVIQPAVSSYISDMVKNGVAAASSTDTSEEAVRARDRGRREVGRGMEFLVALVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P3</accession>
    <name>F9W9P3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_46320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001334">
        <property type="protein sequence ID" value="CCD13947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46320"/>
    <dbReference type="OrthoDB" id="1672059at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388879" evidence="5">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="61"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38066" checksum="FB9112AED78FDCCB" modified="2011-10-19" version="1">MKMMQTWLVLWLALFIIGVVNADDAQGSVKKDHNGEPYQALCKLLKIAVYEFVNKGDTLPDPLKAALNKTIFGRKSGGTLEDLKDLPQDYTEGGSARVNFFGQPYEDPGYYGAPHRWSGYSAPHNLVCLCTKGENGWPVNNSGNQDTLCGETSDTLGAGNEGWTGSKTGQAQMRATWKEVVTHCLKGETGGDLKGALGTFLGKLEHKPGDEANPNRYQLGEGKPSNWSGCDGTSTQGVCVMYYNSTNPTKPQPWWVDLQKAIPEDEKLQEQKRREEEERRKQQEETAKQDSTKTDALKSEPPSTNQTAQHRNDNLTDKLRRLNLTSGTPISRPFSWLLSAAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9R5</accession>
    <name>F9W9R5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_46540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001339">
        <property type="protein sequence ID" value="CCD13970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46540"/>
    <dbReference type="OMA" id="NSAWEAV"/>
    <dbReference type="OrthoDB" id="990389at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="PTHR45635"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="37"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37457" checksum="9E6AFF8A2B0F215A" modified="2011-10-19" version="1">MRNLPTVANRPPVPRYGDSRFHKNANASVGSGGGIGKSVLVQLLGDFIATSVRVPVSRVFLLQCARGELVRCGRIPPNGLEGVEECVQHIIKKEGVFGLFRGGWENELLDAATKLLRITTASVIAQFHLLMAHFFGRGAVLFHFCEPFLQLLITLPMVGLRDAVLYNYTVDIVAPKNSEEQKNPFVEEAYIYNSAWEAVSAVLDRYGWEGLCFNGLDADFLELGAQLISTKLVASLTMSQVNYLAKADGASILRKVAVVTAVDVALRVFLITVQQPFQVLRARVKALRPRDDPTASRSWSLRGVADIVHAEGFKGLWTGLRVRLLGEVGAVLIRSLYYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9R7</accession>
    <name>F9W9R7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1889</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_46560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001340">
        <property type="protein sequence ID" value="CCD13972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46560"/>
    <dbReference type="OMA" id="LLAWMKL"/>
    <dbReference type="OrthoDB" id="17002at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="239"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="659"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1837"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1894"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2080"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1844"/>
            <end position="1861"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="2111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2111" mass="230126" checksum="C3F99A72E77EC0D3" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001380">
        <property type="protein sequence ID" value="CCD14085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21761" checksum="931A679FE7FFF374" modified="2011-10-19" version="1">MSEEKICLRSRASWKCNLAYLRAPEKEKQLHLLPSKLRRCPYCARFGSNAHISRCGQQLVNCAFCRCELELARLAAHEEYDCEERRKRVFCPACEKIVPIQGDVFTDVCQCVDNEPWIVPTPPGQKAKGNKQKKGGAPKRGKKKNGVVESKAAPPAKRDAKGQAGPEPATQPARRGSTKPPVPGVRRPAEVKSKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAK5</accession>
    <name>F9WAK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 198</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001443">
        <property type="protein sequence ID" value="CCD14275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05270"/>
    <dbReference type="OrthoDB" id="405736at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="298" mass="33603" checksum="412E166E4F2D0E67" modified="2011-10-19" version="1">MRDTFSTALQLLSRTPGWRRDVSKGNNIVSNWLHLRNDVLCGKLPSVGSVVSCDGRGILFSGGRVDKLEVLDDMQKLSAVRTGRRDPVQDYDTMHQGAFIDDVDAVICATGYNLRYPFLHDDLRSDLEDPPCLLPQGTQQHNDAPESTTTKPLNHRGLYLGTLYVRNPSIGFVGMQQGLLPPFLLMEAQSKFVSYAFTHRLSLPPDTAGLLSRQDDLVQRYPFLANLYSPHGLGLYSSVYFNVLQEELQVGSRDTYTSAIMERQKWILLTSLLRLVHKVRSMAPLKRKRQHILFSNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN8</accession>
    <name>F9WAN8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1997</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001460">
        <property type="protein sequence ID" value="CCD14309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="309052at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="15810" checksum="4DC49258E8E9D0FE" modified="2011-10-19" version="1" fragment="single">MNPGSREAFPAMPGGAAVLGFCREYFASRGNSRETRAWMLGGVLVAALSLATGRRPKGREEWAERVVSLARAGHLKQRHGSSGAQADALLSTSALQRFMLLLRLAIPSFRSKECGVLVIMALLLVVRTFLSLRTARVNARGAKCVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB29</accession>
    <name>F9WB29_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_05410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001521">
        <property type="protein sequence ID" value="CCD14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05410"/>
    <dbReference type="OrthoDB" id="1665729at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="46012" checksum="AA528561A31FCC95" modified="2011-10-19" version="1">MVVCYCVMGEIYFFCSIFYIGIGMMESRKIEKGVLAIAVVLLFAGVDAYPPGTVFNDDEYNALCSVFQASLDLWNESRTSENGLEKGLESDLRHALFGNTGNKHLSGITQALPNAYKIRILWNRGSRCGGCHQEEKFYYPGSSITHDLMCLCTPGKAAEPFYGYYWWLFGYKANGFKLCGKLKEDMGVNLNHGWYSEGRKKEANGLEKSWKAVIMGCFNGWKNRNITGSQDLTEKLQKLTEAMTNFTKILKQVNGMHKLGWTKEHTPSDGTDEKRIHVHYNTCNGKRKPWWKRLNETLTSKTPEQLLVPRKTQSPSSEPSEELNDGPEEELLEGFAGEEGLEPDVHTTQTSSSSQNNNGTQMQGPTNSTESTVIPLNATASGNSSHPRLEYLRSGSHINQPLLFLGAIFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB50</accession>
    <name>F9WB50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 2061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_50910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IFT46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001531">
        <property type="protein sequence ID" value="CCD14481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50910"/>
    <dbReference type="OMA" id="LPTINYQ"/>
    <dbReference type="OrthoDB" id="878878at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="PTHR13376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="120"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD14481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="392" mass="44494" checksum="4C4AA1DD58DAE58D" modified="2011-10-19" version="1">MGSKKMLVNQPNDEKHTVEEARSVQTPSDHGARTNWVTLPSKEDIEKKDGQDVKEGSRLLKNNPNDEVVPVEDMHTVTTPRSTLAAGENVKGTMLRNAPHDEAISVGAHAITMETPKKMVERNPPSMRNTEEEEMKSTEEESVPTERTRGYGSQRPEAINLEAEVPETSTQNLGYKPQEYAMINASASREIQDLFKRILDYQPQMPDLPAKLRPFIPDYVPSIGDLDPFCKIPRPDGKPDGLGVYVLDEPSVPQSNPAVVLLELRATNIHSMCGLAEAVDSFEDAANRPEVIDRWINDVKKVHYKKPLPTINYQKPMPEIDYLLQVWPQEFEEFLNSGVQFPPCQIDLDLDQYVRMLCCILDIPTYNSLIDSLHVMFTLYQEFRANQHFQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBB3</accession>
    <name>F9WBB3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_51510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001559">
        <property type="protein sequence ID" value="CCD14544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51510"/>
    <dbReference type="OrthoDB" id="388359at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01430">
        <property type="entry name" value="OM_assembly_BamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="161"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="252"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="6">
        <location>
            <begin position="333"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="782" mass="86112" checksum="E7320B18980D8B5C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH9</accession>
    <name>F9WBH9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14898" checksum="E37CA69A4FA72C25" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGESPMSSARARRLFANWKAVSVQQEVVRLAYTEREAEDFVTQLVTRTIAHGNAEHAMERKEIYVPIEEELLRATKWRVCAGEEQSHSLHLRRACGGDCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBJ7</accession>
    <name>F9WBJ7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_52300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001588">
        <property type="protein sequence ID" value="CCD14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52300"/>
    <dbReference type="OMA" id="MSGILFY"/>
    <dbReference type="OrthoDB" id="712010at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="515" mass="53892" checksum="E078E42F6F4DA8A1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP5</accession>
    <name>F9WBP5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001605">
        <property type="protein sequence ID" value="CCD14678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52740"/>
    <dbReference type="OMA" id="AGWCSPC"/>
    <dbReference type="OrthoDB" id="1350271at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03009">
        <property type="entry name" value="TryX_like_TryX_NRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045870">
        <property type="entry name" value="TryX_NRX_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13905">
        <property type="entry name" value="Thioredoxin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15951" checksum="04D3D198206A6FD6" modified="2011-10-19" version="1">MSGLTNFIPNTISLLSKSGNVSLGSLAGKVVFLYFSASWCPPCRGFTPTLVEFYEKYHKSKNFEVVLVSWDESEEDFSGYYDKMPWLALPFGERAHVEQLGTKFGVSSIPTLIAINADTGSIIGTQARTRLLKDPEGAEFPWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU5</accession>
    <name>F9WBU5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15952" checksum="520B4EA29D7484A8" modified="2011-10-19" version="1">MICRQFGKARWHNSFEIRFHSKVRRLSKWTVSHLALYTRPGFVWERLLFSCYFPLKVARWRLSPLNIGLACTSDPSALSRKALILAKVCVCKHVVKKHTSGPNTSPASHGRSGCGRLHAWLWSDVILRFGRNFNSGRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC10</accession>
    <name>F9WC10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001651">
        <property type="protein sequence ID" value="CCD14797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53830"/>
    <dbReference type="OMA" id="CAYASPA"/>
    <dbReference type="OrthoDB" id="125521at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="708" mass="77159" checksum="29B26BBC79A2C574" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC16</accession>
    <name>F9WC16_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001653">
        <property type="protein sequence ID" value="CCD14803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53890"/>
    <dbReference type="OMA" id="PRMGERI"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="579" mass="50432" checksum="264BEAA9775E5CEA" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC41</accession>
    <name>F9WC41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001664">
        <property type="protein sequence ID" value="CCD14833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="15285" checksum="4754ACDF5C433FB4" modified="2011-10-19" version="1">MVYFNTSFPPAFMLLSLLLLFPYIFFPYRCDPLLFFFVCFFFFPCLFMFSLFFFHVFPFVSTCPSFVCLFSLDCLSSPDYPRCRRSTSVLGVRKHHLLHRPQRMNEKEESCSFVCFFVSSFLKKENIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC95</accession>
    <name>F9WC95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001687">
        <property type="protein sequence ID" value="CCD14888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05720"/>
    <dbReference type="OMA" id="CNGELAC"/>
    <dbReference type="OrthoDB" id="1659459at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="535" mass="60391" checksum="852DCA2D9AF3AC0D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCB3</accession>
    <name>F9WCB3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001697">
        <property type="protein sequence ID" value="CCD14906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54760"/>
    <dbReference type="OrthoDB" id="1708638at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24982" checksum="A9280AD1C61BBE7B" modified="2011-10-19" version="1">MPCPPAHAYTVWGGREHFRTSSIHKSKVVSVLKRKEGKEAMAADQLHHFVPSWVSADFHLMLMLGQNTSNSNEKQHISNAFHGLVLRTTCQHPAAVSSTHDDIVTTIILQTIVLANHEAVAMKCTTEAAARLQAQAARLAILNHTASLLTADTGTATVARPIALQEFLALQVGAATWTATRTQAKARLAARGHKQARLPLIDSTPILTGWLICKATTTFHMWRLSVTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCC4</accession>
    <name>F9WCC4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54860"/>
    <dbReference type="OMA" id="PNIVIMN"/>
    <dbReference type="OrthoDB" id="1277051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="25410" checksum="1C260C49B0D01754" modified="2011-10-19" version="1">MNPVPASSTSSGKKSSSAPAASETTHMAKYKIVLLGDQSVGKTSLVTRFMYDTFDQQYQATIGIDFFSKTLHVDNRAVWLHVWDTAGQERFRSLIPSYIRNSAAAIIVYDITSRVSFLSTFDWVDEVRKVRGSDVVVALVGNKCDAQERREVSTEEAQKKADEYCLIFVEVSAKQGTNVKSLFRKVAEAMPVADVGGSVAAPVGKRRDPFLLTPSQLQQQQQGDTRDGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCM2</accession>
    <name>F9WCM2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_55820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001738">
        <property type="protein sequence ID" value="CCD15016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55820"/>
    <dbReference type="OMA" id="GIANHAS"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39746" checksum="8842525F9EA5BBF0" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGRPPMTVDWRKKGAVTPVKDQGKCDSSWAFSATGNIEGQWKVAGHELTSLSEQMLVSCDTDDLGCRDGFPDIAFNWIVSSNKGNVFTEQSYPYASGGGNVPTCDKSGKVVGAKIRDHVDLARDEDMIAEWLARKGPAAITVDATSFQRYTGGVLTSCISKEMNSAALLVGYDDTSKPPYWIIKNSWGKGWGEEGYIRIEKGTNQCLVQEYARSAVVSGPPPPPPTPTFTQELCEGAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD33</accession>
    <name>F9WD33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_57300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001816">
        <property type="protein sequence ID" value="CCD15181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57300"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390193" evidence="4">
        <location>
            <begin position="26"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="56"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="21448" checksum="ACDB930884930168" modified="2011-10-19" version="1">MEWEMWRSVLLICFFVVNGGRYVEADGVNKEVFDKLCKIKNGVKLLINQGGRAEVPLQEALYGKGGQDPLDNGGTFTGGSRCGLVHHGRSTYCSNLPGPRGLHGSSGHGCFGDTLLGTLLCMCVPGGDKNDLCGLGSDVTNQGSWTGEIGGYRDNHPQNLLKKVWEAIKQKCTGNKHCSKHFRTLGKFKKCCRRDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC7</accession>
    <name>F9WDC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2352</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_58110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001856">
        <property type="protein sequence ID" value="CCD15280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58110"/>
    <dbReference type="OMA" id="CAIAPHC"/>
    <dbReference type="OrthoDB" id="1664903at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012429394" evidence="1">
        <location>
            <begin position="16"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="410" mass="45866" checksum="38C645CC776083DB" modified="2011-10-19" version="1" fragment="single">MCVCFIAVHCLCVCAIAPHCQFVSLLARPPCYFLNSLIVSIALKARHKHKRIILKETMRPVRASAEMERTRVAATSHEVVARPSVRWTLDNVVEDVLMEDCGGLGDMGLHDFLMEHFEKKFGTLDVSMCAFIHNPGACIGGQRSREEVTDSEPYKELLGKYELYKTMREGVDSLHDMRIFSLRHWESVAAANEVEGIDDSLRGKLNAALLIARRNEERMMVGNASSGVEIDGAYDAVFNARWSYVVRSDEYGGGTLGMGVLGVVPREQVHLWSEAQANVIPDPWKPWEGDVVSGVSGKLVMAVLSSQKGWPYMLFSADDVRKERVQSLTEYNAVCDAYIRKEDLRVWHIVKKNIDEWSSGVGIFLPFLLIGTRGIGKSCGTGSLLLYQLLHSPFERLEVVAYFVSGRAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDM2</accession>
    <name>F9WDM2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2380</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001886">
        <property type="protein sequence ID" value="CCD15376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59030"/>
    <dbReference type="OMA" id="CAEICAL"/>
    <dbReference type="OrthoDB" id="1466354at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="71"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17634" checksum="B9C6CA5253486E3D" modified="2011-10-19" version="1" fragment="single">MRNQYRRLQLDVLKHGKFLRFCEVSYEPLSDNTMLEQKNRTNNSISKWELVQRTTGNIPLNLRHTTPVPFAIDCAEICALLSRGEDVFLILVAQYRPPLDAVVIEFPAGLVDPEEDVKAAALRELHEETGYTASLEDVISVSDALCLEPGLSDSCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDW6</accession>
    <name>F9WDW6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_59890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001922">
        <property type="protein sequence ID" value="CCD15471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59890"/>
    <dbReference type="OMA" id="CERWRIN"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394917" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="842"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="886"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137029" checksum="291CCB514DE12A33" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDZ0</accession>
    <name>F9WDZ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001933">
        <property type="protein sequence ID" value="CCD15495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14409" checksum="C99EB40228CAE663" modified="2011-10-19" version="1">MVCGMAGTHSLTCSAISAKHNKRKYHRSSASFPLLGHVQGPLPPHTSECRKAIAFTHWVTHVPLKHTTTHFIPSLPLTHGLALPSLHWPWRVLRSLQSFPLARLSNYNKREMASTPVTTAHPLGPMAASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE21</accession>
    <name>F9WE21_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_60330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001941">
        <property type="protein sequence ID" value="CCD15527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60330"/>
    <dbReference type="OrthoDB" id="1672316at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="88"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="386" mass="43440" checksum="FD6332477E34E8CC" modified="2011-10-19" version="1">MHIRRFYFLIFLIFLSFTRIIVSIVVILRCAEVIVMFGLIATRTNATGKMERSFNNDFDILCGVMSATVGLWENIAVNNEDFSEEVNVTDLGKKIEKIFFGPEWDGYSAGLWNFPEKFTRKNPKRSEVCKSNSDSTDMPSASKSLASTFLCLCTLGNEKKVCADRMLGTMVNGQTMIQAKVLKIYSKKIGVSTTKDGLKMNVAIARKAKHKESKETFKTKLKDLEDKLKNNTGIFVPKDMKCDGKTPCANVTESPTWLENLRQFKDIAESIKEKPKATPPVQKAPERASLPSPLSAQNQEPNSQTEHEPEPIMFQAPVETNKQETRKAPPPQTGPRPEPESENRVTNSSPNKAEKTEEHLPATESNETNWTFLTMPKWPLWAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF8</accession>
    <name>F9WEF8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002005">
        <property type="protein sequence ID" value="CCD15666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11580" checksum="947E88C6715582C3" modified="2011-10-19" version="1">MPMQCYGEFLVSDEQRLVHILHHILPFHLLQAIMLSGPYTLNLTRENLSLLLVLEPNMTLLAPASFPSRGVLFHFHYAFSPMSPRSLFQPPSAEVFFYSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEH2</accession>
    <name>F9WEH2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA (guanine-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_06960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01002013">
        <property type="protein sequence ID" value="CCD15682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06960"/>
    <dbReference type="OrthoDB" id="141294at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="PTHR12189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="Pox_MCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="8">
        <location>
            <begin position="101"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39998" checksum="179CBBFCC28371C3" modified="2011-10-19" version="1">MIWLLDASKFKCARCQSVSDAGRKDPRSQIYWCKGCWMETNHGDCLYCGRTFVVGKIDCYSQNFYCDPCWTTFSTINSGAEAGHVGLLPSNSSLPIQALVWCASLLIDTIASKTPTDDVLDMCSEGLITPKWIKNKTTRYVGFNIKASVVDETKKFMESLRQEMPSASFYDIICADVLAPDFWSHVLMKVHPRQFHVITAFSGLHHAFETESKAKVMIESVAKALVPGGVFIAFFLDVYSVFAKDLGCTDVFTIEWGTDFVPRIGQHVLLSMYGGPFKKLNVIPVDFLVAVGQVHGLNIITEACSSFKALLDDDKNFTKLISNSEKEYLSIMRAVAFRKEGGQRVCAPPSTTDNANREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI5</accession>
    <name>F9WEI5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002016">
        <property type="protein sequence ID" value="CCD15695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07090"/>
    <dbReference type="OMA" id="IARHESS"/>
    <dbReference type="OrthoDB" id="1448333at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="318" mass="35222" checksum="D7CF8D3F9CB2D019" modified="2011-10-19" version="1">MDNLHSVVRDVLVFHPHTIRNYGAASAVSSHGGNKRLIFMSEAAESLVTELIRVLSRGLHGEVELLTVLETLRLVPRKIMRHEDESSPLREALYRLRFSEQLIYAVRSLFTRSGAAVRSRALLRLMLNQGVLLAALELIGQWSAVELRAFYVDPRVSVLCNMEGPLWDAFLGACAPIGGVMLEQIVAGVCVGTSAVTFQMMLLPPAARRTTVGRLLPPNEGIRARNNVVLGSEGALEAERGIGVREFTTPTAYLSEGQMPVRTTEMPTIPDLNYVMSTLEEAEFILITQWRELATSLSEQEALIFEMLDAQQTSTLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEJ6</accession>
    <name>F9WEJ6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_07190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CAEQ01002024">
        <property type="protein sequence ID" value="CCD15706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07190"/>
    <dbReference type="OrthoDB" id="948528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394945" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_dh" evidence="7">
        <location>
            <begin position="127"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="53886" checksum="1AFE777EE821C84E" modified="2011-10-19" version="1">MMWYSALLSSHCLLVVFTKVLLQIRPTEMFRIVFRHLQVAGTKGAHLRTLQKVDFSDPTIFRQKSIWWLLRALFVLRMCSIEFISNNSVALMKRAESVLGPFLTYNTIVKKTVYGHFCAGEADRELRNTIKSLEGLGIGSVLDYAAEADAEGFAPAPGMAEAPNLSMASLVNNTSVTYLPHKQAYDENMKLYVMCVLHSALHKPKGGVGLAAVKVTGMCDPQLLARVSAILHMVHRDWIEYFTEEQPPPVEECNVVMGTKTEHKRYITRDQVRKGLTNLAASRKYTEDEIKAVLDVLDPDNEGRTNYYKFKTVVSEAVLALDPTHVQKIIIDKLPKLTTEERELWRQLHWRLSVIVRTAKDLRVRVLFDAEQTFYQLAIDNIVLQFQRMFNRKGATVYNTYQCYLTYTEDRVFNDLTRAELEGWVWGGKVVRGAYMRQERETAEKYNYKSPIFPTYEETNACYKAVQSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEJ9</accession>
    <name>F9WEJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 279</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002025">
        <property type="protein sequence ID" value="CCD15709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07220"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389034" evidence="2">
        <location>
            <begin position="47"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="867" mass="94498" checksum="01742AC174207FD8" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM0</accession>
    <name>F9WEM0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002034">
        <property type="protein sequence ID" value="CCD15731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07430"/>
    <dbReference type="OrthoDB" id="1674434at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389037" evidence="2">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="348" mass="37843" checksum="74205F4DC8F0FF35" modified="2011-10-19" version="1">MKIQFLVFICAVGAVAGAEDGGSVVPKDHNKDAHNALCNLMKAAVTKWGDGGKTLSPPLKKALGRTLFGKDDGGTVDTLKGKLPDDYEGVVKQTDSRNFACGQPRNDQAGYGNLHQVRWSGHSAPHDMVCLCTAGSYGWPINGTGPSTTLCGKDKGALKADNKKGWDSANQGEDEQGKEQINATWVEVVTQCLQGGKGGDLKQALNTFTESLVHKSGDEVHKNRKQLGEGTPNNYTGCSGSPKLGVCVMYYPDDKHATPWWIELPNALKEDEQLQKQRQEEEKRKQQEEAAKKDTNKTEDIKSTTPTTNQTEQNKTATLHETIRKLNLTSGTPISRPTSWLLSALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ6</accession>
    <name>F9WEQ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_00820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002051">
        <property type="protein sequence ID" value="CCD15772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00820"/>
    <dbReference type="OMA" id="MIMISAG"/>
    <dbReference type="OrthoDB" id="318396at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_1" evidence="5">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_1" evidence="4">
        <location>
            <begin position="80"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="25367" checksum="070A7467B83B1AEA" modified="2011-10-19" version="1">MSPPLELFLEMMPQIVPRYFSISSDSLSHPKSVMITVAVVDDGLCTNMLQRAGVGEGIPVFVRKSNFHLPLRAKERPIVMIGPGTGVAPFIGFLHRRSAWLKKGSKIGEAMLFFGCRRRGEDHIYADFTAECLANGTLSVLDVAYSREQPEKVYVQHRLAARGGKVWEVIREGGGIYVCGDARNMARDVEAQLLQILQEHGSMDQAEAATFLEKLAAEERYLKDVWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEV5</accession>
    <name>F9WEV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002067">
        <property type="protein sequence ID" value="CCD15821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08220"/>
    <dbReference type="OrthoDB" id="1719487at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18426" checksum="D2C808CF128EBC27" modified="2011-10-19" version="1">MSPGEGTCISISIYRYIDMHVLLCKYNGNNILLLYFSPFFSQYNFCASFPHFHFFLCFCCCRYRVTLVSATHGSVRGPGVLHAVDERVLTPSKRCPPARVELPKGVFFKCVWEGTSFHFRLPPTVSHEASFVTRCGDTNEVHCGRKGVSHLLVTGTVGAPVVTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEW6</accession>
    <name>F9WEW6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002071">
        <property type="protein sequence ID" value="CCD15832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14115" checksum="E2F8460755C87624" modified="2011-10-19" version="1">MTSRPMSNEAIWLDIYPRKRAICAQNIPPLPSGIRTHCLFAAIAIQHALAACRRYHFSAVPASPWAHCEPPLRHKAHQTLIAQVFSPIEGSRFGQTNTHQSLSRRCATHKLCRAVAWEGLALSRCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU0</accession>
    <name>F9WFU0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11200"/>
    <dbReference type="OrthoDB" id="1714414at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="20101" checksum="78E77C82A21A23AE" modified="2011-10-19" version="1">MNSSSLPAGMSADPAAIMLASRFCSMAFCMATKRSYVCSKKTDSLSQLRFSPSCMKALNRTNSPHHVDLIEFFARTPLGFSKRSYSLLLTFSQYDVLPWLYAKWLFFWFFVAGDSISIQQVTFVHITTAHTSFSIMGIIPTNRGYTKLDAYKTIMVYMNRAYNYHTKTKIINMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFW8</accession>
    <name>F9WFW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_11470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002192">
        <property type="protein sequence ID" value="CCD16198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11470"/>
    <dbReference type="OMA" id="WAGQEYA"/>
    <dbReference type="OrthoDB" id="1308952at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="PTHR13505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19805" checksum="7232DD210EEFC2C7" modified="2011-10-19" version="1">MAKDTAKKNVRSNAVRMQVFSLITLAINALCLFLAAWREGSILCFSSIAGLFFWAGQEYASLALLKHFAKPVYGPKGELLDCSDVSDPKELGIYSLAQDVLWVCWVVQLLCFLFHWGFVVLYLPVPVVGLCKLWCFVSPLFMGPKSTPGLENEFGPGPMSRSERRKVEVLRRKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG49</accession>
    <name>F9WG49_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002229">
        <property type="protein sequence ID" value="CCD16282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01430"/>
    <dbReference type="OMA" id="PYDESHQ"/>
    <dbReference type="OrthoDB" id="1573760at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="672" mass="67313" checksum="1B14C32F3DBB8494" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG75</accession>
    <name>F9WG75_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002242">
        <property type="protein sequence ID" value="CCD16309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="13591" checksum="362A56A7C02BD5DB" modified="2011-10-19" version="1">MVRRIEKVGPDIRSPVGKADQREATLITRSNGIVKEAEKLVENVRDLRRKAGGKRISAKRHLHQVIFGEYGGDETGELGASAETIKKIFSGTTFTESCGGKGDKPAWKSLINGFICLWVHRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE0</accession>
    <name>F9WGE0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_01500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01500"/>
    <dbReference type="OrthoDB" id="1708240at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394755" evidence="4">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="20886" checksum="AAD07813D9E2E6B3" modified="2011-10-19" version="1">MACFVNMIAVFIFSLLGHVRANTGAQVQANDNAEKLALLCRIYNVAKNPPINHVNLQDPLEIVNEINALNASLAEEKQFSGAEQMENSSVAQLQSTVIREVAVAQAILKRIARRAHTILEDIQKVNATNDIEKIKAEFNKVIFGEGMNESDLCKGSLKGVVDRGNTCGIPGLAHKGENAGKNLLVDFSAYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS8</accession>
    <name>F9WGS8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 541</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_14330</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002316">
        <property type="protein sequence ID" value="CCD16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14330"/>
    <dbReference type="OMA" id="YMGIRIW"/>
    <dbReference type="OrthoDB" id="1135385at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="PTHR12111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="291"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="38438" checksum="CE242311530DF02C" modified="2011-10-19" version="1">MAKINATYSSGYYLAPDVDYRKLEEQQRLERKRNMKKDEALPQSERSAIRQTFAMPFNVVCLHCNSRIARGTHGYVNRRATDDKYMGIRIWELEFRCIFCKGHIYLITDYETAKLTGGYHCSRNCRRGEGDFYGMNQLNEELKAQQAAEKAEKGTVDALERENETMRQLQERDRLVEEVVESRAGMEEIQTRDELLQAIRTKKLPECPATDGEVTDSAGRATPEEEEAYQRFEAQLRLWGSATKPPPPQHGWQGPANSYVDGDEADISVALAMKYAGHGDKRGNVFMDDSDDGSCGDCDDKPAQLAKAGMSSVKVPSAAPKKDSAKTVSVSQRGSVLASLLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGV9</accession>
    <name>F9WGV9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_14610</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002336">
        <property type="protein sequence ID" value="CCD16547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14610"/>
    <dbReference type="OMA" id="HQENCPS"/>
    <dbReference type="OrthoDB" id="1242599at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PTHR11947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="SSF69012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BCDHK_Adom3" evidence="8">
        <location>
            <begin position="90"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="50849" checksum="9C9325B1BE5A1511" modified="2011-10-19" version="1">MFRCCARRFSPQLRDIINRLDFIEEQIIDLKAFREAVEAILPGVAAAADVLAKKRREAVQQINVVVKDPLTSEEFAELNQFYAVQKVQPLALSNMLRIQTHEDLYSHARIVRREYLVRVAKRARALSHAPVGLSQMRSIQELRRWYEWSFHDVKSIKAPVDTESALKFDTLLRRVLLRHYNVSALLSEGMHELGRRQRWSEHSSSDEVLSEAFEEMQQFFVEFCMGRVRLRFIAGNYVQLSTKILNVQPKDYEKLTAPMYFGHDPDTFVGQICQRCSLVTLVECAIRSAKLCNNDINILLRVSADPDTTFPGIPYITYDILCALIDDAIQANILRSEKYGVPFTPVIVTVAQRKGSEQFSVRVSDTAGGLPLHIARHVLKYWFTYKCTDDMLKHAKTWIHSPIRLPYAYCAARVLGGDISVVSVDGYGTDRFLHLPAEGMKGVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHP3</accession>
    <name>F9WHP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002467">
        <property type="protein sequence ID" value="CCD16837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16351" checksum="23ED1FBF325D9B0B" modified="2011-10-19" version="1">MVKVVWVWTGWGEIYPRVSIAVNNKIHKTKISIEKTAFFFIVRINDQSSHPTPAKKRKCIDAHHASRHSSVGLRLGERSHHPLTPLGEDYFPPTSQWMVTTACTLVQDDGLHWNPLPLHSCCDVSLSDVIPDLMVSNMCRASAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHQ9</accession>
    <name>F9WHQ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 685</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_17380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002476">
        <property type="protein sequence ID" value="CCD16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17380"/>
    <dbReference type="OMA" id="TARICHR"/>
    <dbReference type="OrthoDB" id="787827at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="48396" checksum="BBCB766489BE1C62" modified="2011-10-19" version="1">MENIRRTSRKLGVGAMGVVYEGYDEESGRFVAVKEIPVYDVDVSAQEDSCVAGGLRSILHEISLMERLAHPNLVTYYGARRSAAGVEIIMEYVNGGSLDSLIRRQGCLRESVVRSYARDLLEGLSYLHNTARICHRDVKPANVLITADGRCKLTDFGVSKLLDDTVGMHTTVGTPWYMAPEVVDCSGNTTNTTSSIHGCVDGADNDNIEASKLGSSYTTAADVWSFGVTVYEMITGKKPFGGNLKNAAAVLFSIVSNSTPTPRLPSTCDASPLLQDFLDLCFVRDPTLRPSARELLSHMWFHEASSPRHEKRLEGSTSCPSQGDSAAARSLSTTRPVDMDGNTSSETIVTTTNALVAYPPALHLNMMDIADILTHAAQENGQLVTSASSPNKSRAEHIKRANTGEASSAMEGFQGGFWSPEGHFIDLFMPQPPCRGEPKLTQGTPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHX2</accession>
    <name>F9WHX2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 701</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002493">
        <property type="protein sequence ID" value="CCD16917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18000"/>
    <dbReference type="OMA" id="DWIDVEG"/>
    <dbReference type="OrthoDB" id="1513223at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="21929" checksum="CE91B2870ACE2AF2" modified="2011-10-19" version="1" fragment="single">MLRYNPLASAVIRYARAASSGRGLNKPFKNNSLKTAAKCETTFPPKSFIATWLTWAPVAWLIKNSLSIACYQLVLEGTFTVFCAWLLIRGHATPMGMKQRLESLYYPFTSFVSWDGGHHDTGFTITRFHVSAEALSAIHTSHNIASGLLPLQLVVLGLTYPAAMRVWVRASSRLGALWPLSATSEKVTNYPFGKGKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI27</accession>
    <name>F9WI27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002519">
        <property type="protein sequence ID" value="CCD16972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18440"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16521" checksum="46664810B7FB899E" modified="2011-10-19" version="1">MHHAIGEPMRSHDASALQLVKGIYFNTTTPAAFRAHVSRKEKVHTIRKVTKIGDNDQRVWVERSMLLDVPSGALVCPKDGFRKKAALGVSAPACSYRTQCVAMGAVLERLVESIGRNATHQTKAAVFLNSLSLLVALNTGRAVVIDTARRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI54</accession>
    <name>F9WI54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_18680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002529">
        <property type="protein sequence ID" value="CCD16999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18680"/>
    <dbReference type="OMA" id="KKVDRYW"/>
    <dbReference type="OrthoDB" id="1467344at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="24038" checksum="B82403AB1A865CF7" modified="2011-10-19" version="1">MAGHFRGAVGKLSKPKKSRTAKKAKSKRTVALVKRAPKLSSDALQRRIAELTGATSALSTSDVEPTEAVADLKRKKSKASRKSASRNTSTLKTPIGKAAIEIVGKTTEKVVPMAEVAPERSSAEAMGLKLLHRAVKNQSHNRLLPHQSAQDYEYRLRSVATAGVVCLFNSLSQSRRASLAVDAEERHLTADKVQEKKQVISKEAFLEALRQPKKVDRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII2</accession>
    <name>F9WII2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VSG_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_19770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002600">
        <property type="protein sequence ID" value="CCD17130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16643" checksum="D695E21200F0237F" modified="2011-10-19" version="1" fragment="single">MATYQKVIQLKSSDKEDAEFVSYTVKRRIANEKIKHAMEKAKDVYNRMEEELIQAKKERTLARNNLVHAIYGVQVGELPKEENIADVLQNVSRSSISNKDGGLKKVKYHENSDSPTCGETGKNGPGFTLINDFYCLCVGRENAKAVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIN3</accession>
    <name>F9WIN3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002620">
        <property type="protein sequence ID" value="CCD17181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02230"/>
    <dbReference type="OrthoDB" id="1722828at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="207" mass="24824" checksum="41E7D6E3E7B6918C" modified="2011-10-19" version="1">MEFGKKGKFGKKGNLAKREFDKKWNLAKKMEFGKKKGIWQKREIWQKKGIWQKNGIWQKKGIWQKKGIWQKNGIWQKKGIWQKNGIWQKRGIWRKMELVIKGKFGKKREFGKKMEFGKKGEYGKKGKFGKKRECRKKTEFGKKGNMAKNGNVAKKLNLAKRGIWQKREIWQKKGIWQKNGIWQKRGNFPKSRDSLKERGFGKKMKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIN7</accession>
    <name>F9WIN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TCIL3000_5_5310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02270</name>
        <name evidence="2" type="ORF">TCIL3000_5_5310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002620">
        <property type="protein sequence ID" value="CCD17185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02270"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_5310"/>
    <dbReference type="OrthoDB" id="1683053at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC90766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="27893" checksum="21A22C480505386E" modified="2011-10-19" version="1">MKEFGRIEKEQVAKPDVERLRRELETADRRRSDAQEHRRVRETKLETARLELANWNPEFERVTQASAEARQLQAWLLAVSQSEEVERELAKARGRQADCELRQILAEGLHHLAAATQGGDAAERELEEALEEWEEARDELKRTEEKLEWAIEAWVRAIQQWVEGPKEACEEAKENLEKAEEELERASEAWNATAIEKWMRANEKVRWSRRAWDRPWAEAREEWKGAEPRLYGARDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS0</accession>
    <name>F9WIS0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_20550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002630">
        <property type="protein sequence ID" value="CCD17218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20550"/>
    <dbReference type="OrthoDB" id="689446at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="357"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="44655" checksum="E1C3C60F029A32F4" modified="2011-10-19" version="1">MDDEWALPISQRFHGERGGIDAVDTRWHPATSEGDGTFCEPVDLAPVGDERAGEQRCIPRWAAGSDVPETLLTSGESRTLALAETAFHSSRGLEQRADQERTWPAGCVNGGVCSTYGHRGASKVDKVARDHNSGSGTLANGMGDAKTRRGIAGGIGPFRRGSAANWRRASSTDVKHRVAPLPTAPVSTDIGSAPQEGRGKAAAASVWAASRVATNAAALRRTEVVADESIVGACAKPGFQGHCVGAHPVVHDGHASRGENSPGRNVPSSAASTRVSTVASTTHNTTVMTAAAPAPLAKFTRPVLDLSIHLLSLYKGINAAYCKQRRMEASGAKYNNGFDDKEGHYVVLCGEEILNRYTVREVVGKGSFGTVVRCFDSKRLEDVALKITRGGLSFRAQAKLEIDILLCLNKNPSLNNLVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIV1</accession>
    <name>F9WIV1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 837</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20830"/>
    <dbReference type="OrthoDB" id="1688976at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="26666" checksum="A9E7A508A0F15685" modified="2011-10-19" version="1">MHCGKTLLPFTLHWAMPTLECVVHREGEHHKLVLHLSCGMLAYASQAGAIMLVCTAASCTHTKCLPFSASMCLPILRRFLDLFSSTFTSASCTPFSFPVFTHFALFLCMGRLGQRRWPLRPAVVWMFLLHVTDQPFVVILFAAYEALVSGWLLQFSRVILTPIGLLHALVSGASCYALHMLTPWALYCFLILVNFILTRICSLVNDVVLFWLSLLYGCFARTCLFSLPYNACTLQYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ31</accession>
    <name>F9WJ31_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Palmitoyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_21600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01002674">
        <property type="protein sequence ID" value="CCD17332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21600"/>
    <dbReference type="OMA" id="AVWKNIT"/>
    <dbReference type="OrthoDB" id="1075690at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="120"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="311" mass="34532" checksum="C70F4C0E9338BB7D" modified="2011-10-19" version="1">MQVPVPSEPEDSVEALLSHEGRCNTSSAALGRLTRKRCCGRTFIWSPDACIQLLPTGITAVLVFGVVFTLWSELGVIELLALASFLFSAAASAFTLCSSDPGVYPRLRLGEIDPLRERMDLVYCRVCALRRPPRVSHCYECDVCVLEHDHHCGVLGGCVGQRTMRWFMLYLISIEGALFIGVFWLFRALIHLGPEIAGRGVRLEANASKVEETDVAPHAPATSMEGEDMRAVVIVLLFIAVSLISMLVGGMMFYYFYLVVTCPTRRESQRKSKRTQQSLTFETIKMNVARVIYPPPSLLVESPTLNVEDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ91</accession>
    <name>F9WJ91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 887</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002700">
        <property type="protein sequence ID" value="CCD17395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22160"/>
    <dbReference type="OMA" id="TEVPFLW"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="461" mass="53096" checksum="4B1E553F1CE99092" modified="2011-10-19" version="1">MYATHANARYIGNRKRQSDGVQEADSRGLRDAVGPDAVKRLEKALSAARRVEENRVRVMPRSAEVINGLYDSVYNARWRCVITGKMYKNEPFGMKLLSAKTEVPFLWSRGDVDMTPELGQSYDIEEMLVRSEKVPVVAVLSSALGWPNRMHTPQQPLQALPAPQGESDDYTHLYIRKEMMRVWYIIEEELDRWLKPDECRMPQYHIAIGTAGIGKTRGLGPFLLYQLLHYSSEELCAIAYFSKGEVCILHRHKGNTPGMAVYYNVQDGVSEIERMANQCRKGYAIFDEHKKEIFPYSFPPCWGALVMSTPSPERFEHWVNRYQALPIYINCHDNLELKVVHALGRFSTLRQEVPLTEEMIEGLKREWDELELRVRKVGPLIRYVLGSHFHSRWEDVEEVLQDSSRQYRRCSSGASRYSINWKEHAALFKTTRYMMEGAEVGICEPVSVTVHKKLNSVDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA1</accession>
    <name>F9WJA1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22260"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="17912" checksum="E9696B9791AF66CE" modified="2011-10-19" version="1">MRHISWRVLSPKEAGGRKARAPRRVGAPSQIPPDMRSNTAHGSFEKHAHVSSEIHTLPPTDTHGGDLPLASFTPAVAAHNACQPAFPKTSARVSRVRSSAAGFSPNTITGWQALTSRECGRHCPEACSSSNTSPAISPSPRRSARRHGGSTHGSLASEFAFNQFNSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG2</accession>
    <name>F9WJG2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 906</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_22850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002721">
        <property type="protein sequence ID" value="CCD17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22850"/>
    <dbReference type="OrthoDB" id="1655876at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="751" mass="83354" checksum="6734DF27DC955DD2" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI8</accession>
    <name>F9WJI8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002732">
        <property type="protein sequence ID" value="CCD17493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389225" evidence="2">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="16676" checksum="D92DE91B60CBA9EB" modified="2011-10-19" version="1">MFHYLLFPYFLSFLVWLLRESSENNQWSGRRLTYSHAATATRIAAWRVVSKLFERCIVSLLFMLLYLFRYLLLLFFPSLFHRAYVMRVVAMARHAFTFYGLFFLWRLELILACNAVTFTRYFVCILTLWVCVGIFFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJS8</accession>
    <name>F9WJS8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002764">
        <property type="protein sequence ID" value="CCD17586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02540"/>
    <dbReference type="OrthoDB" id="1718951at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19086" checksum="C515BB628A3D145D" modified="2011-10-19" version="1">MWWRCFSKTLGIRRKSTCTVFCSPPIHLFIRTFPGLVSQTLPGTRGDAWEKPMDGNKYGKSSPACYGNSECWHSSWSIMRGRRRVGGHGNGRCGGSFSSWMRRTMISWRGWYGQSVKCHRNHVGSWRRRTRLDTRGPFRCRILQSRGPPYKELFMLIVSLDVFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY5</accession>
    <name>F9WJY5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 966</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002788">
        <property type="protein sequence ID" value="CCD17645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24490"/>
    <dbReference type="OrthoDB" id="1718672at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="21230" checksum="A77291B0709A6F72" modified="2011-10-19" version="1">MRARYSDTTGFLSFRWVGIIPTHCPTHTPIPARITLTYIGLLHVVPRLNDGSFFELLAITAHEARRHNVQRVTSMSATCLLTIAGNIPLSTCATSVTVACCCTRLHVTRSQPIGALQSLRIPPGWLGSLNSSSTSYQHHIQLHTRKYARTHNVRPNAMERHLTHNNTPTVSWSLCLTPREENGGASATRHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK50</accession>
    <name>F9WK50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 985</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002808">
        <property type="protein sequence ID" value="CCD17711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24970"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="300" mass="33657" checksum="C63E10DB25B3DAC5" modified="2011-10-19" version="1">MIPSAYFPRNTDVSREAPDTLVGANGSMVIGADVNSHHVLWDPLRPSDNKGEYIVDWCVQNNRRIANTGLATRRQRGTVALSSPDTTLCRDCEVSNWKSALTPYSDHHWIPFDVFVGVSLDVTAPSKTARALYSWNKARWNEFRNLSDDFIFRGMKRSAKCVCALSEAIATGVRMAAKRTIPKGKGVALLFWKDEVTKLDKMAQECRNERKRDARIRWRRKVLVDTAMGRWKENVSKLSTMDTASCNLVKSIYAPRPLTSPALMVVVVDGHPLTKRQQAQALANMHMARSTNGLARVGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3H4</accession>
    <name>F9W3H4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_26470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000411">
        <property type="protein sequence ID" value="CCD11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26470"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394659" evidence="5">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="36994" checksum="B8ACE3F0D2C35FF7" modified="2011-10-19" version="1">MFLVFVGMLMMALSGSSLGTGTSEQHNHNEDHHDALCALLGAAVRKWKRTHNPTTKKALARAIFGNESGGNLNTLLAGLPETHHKPGNRKNWCGSCAYGGDHYPGKSIPHDLICMCTVGEGGFPFGQHSHENGKKPTLCGKGATDLGCEDGNGCHSNKHWWTSSTKSHNGNGEAKVHLNVTWEKVVKPCLQGRYIGRVKKTLLEKLNVGEYSSPRWGWGHTNCGGDHSDVCVSYGHQCHDNPNSPQWWKTLSDALTATEDTHAKGKSTRSSRKRTRRNAGGPTAPEEEEDDSEEDEPEDTVTESTNSHNRQLPLLSHQQSGTSLTHPHSLFLSAVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I1</accession>
    <name>F9W3I1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1055</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000413">
        <property type="protein sequence ID" value="CCD11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26540"/>
    <dbReference type="OrthoDB" id="1717987at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="286" mass="32502" checksum="DA3A0F90F3935465" modified="2011-10-19" version="1">MGIWQKGEFGKKGNFVKKGNLAKREIWQKKGNLVKRGIWQKGEFGKKGNLVKKRNFGKKGKFGKKGNFVKKGKFGKNGGFAKKGNFGKKGNLAKKGNLAKRGIGQKGEFGKKGKFGKNGDFGKKGNLAKRGILVKKGIWQKGNFGKKGILVKKGIWQKGKFGKKGNLVKRGKIWQKKGNLAKKEIGKKENFAKKGIWQKRGIWRKRGIWKKREFGKKGNFVKNGNLQKTEFGKKENLAKKRIWQKRDFVKKWNFGKKENLAKRGIWQKGGFGKKGNFVKKVEFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3J5</accession>
    <name>F9W3J5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000419">
        <property type="protein sequence ID" value="CCD11713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26670"/>
    <dbReference type="OMA" id="YFEQEEY"/>
    <dbReference type="OrthoDB" id="888304at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="PTHR10826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="SSF54529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="260" mass="30152" checksum="A68BC18DE5181C5F" modified="2011-10-19" version="1">MRRMVSHCRPRFLTRLCSQVSESKIYSNGDSPKISTRVLPFRHRKLYSITLRELHEESLRDFLPPKPAIPAGWTIEHQVGSSRFDLRKVHKADGCTEEDLHVVALMESKKYEETYRMDNGEREEEDYIFFTLFIKKSNCNGGLEFGLTSIDMELVMDTLVVHSSDREIDSSVCSVAPSFRIGTNGGSSATNNIGHRRCRDYLYRGPMLNELDDDFTDEILDYLDERGINNGFAEYVMAQAHYFEQEEYLNWLHLLKVFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P9</accession>
    <name>F9W3P9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000450">
        <property type="protein sequence ID" value="CCD11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16686" checksum="A43A57E58861BBA8" modified="2011-10-19" version="1">MTSTPAEYSQSFLEMRVFNTFIISFFNVFLIADLNRKEMTFNLIRENLALIGPISSWSQLQWSVTPPTAETIAMTFTVAVHLFIFRSTVAQAPSALLPSSRRYTKEIGSNTTRCICKFSLRCFPPPTSSAEWWPTLSSRTRTGPSTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W499</accession>
    <name>F9W499_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_29130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000533">
        <property type="protein sequence ID" value="CCD11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29130"/>
    <dbReference type="OrthoDB" id="405234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="239" mass="27774" checksum="E640749F6F7A3A3E" modified="2011-10-19" version="1">MVKNMLSRVMRRTGRRTGWVWLCAGVSLILMMLCVPWGTRVDIPIRLREGSSFTTKIHDSTYFRFIPSDVVSTWEAREFLIVMGIHKIDIDDLRRRSDLQRETFWKYDGVVRQGNNFNVELLPLYLLALHQDNGYEISESLWEEATKSHDVIILPTSDVRPSTRKRIGEGGSCGLAAEVVMSRKTYLLLQFALNMFPSAPYLVKGDDDMFMRVPQYLADLRVMPRRGLYMGRMYRARLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4C0</accession>
    <name>F9W4C0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein TCIL3000_11_9100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_03040</name>
        <name evidence="4" type="ORF">TCIL3000_11_9100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000539">
        <property type="protein sequence ID" value="CCD12009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.9100"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03040"/>
    <dbReference type="OMA" id="FMESYFR"/>
    <dbReference type="OrthoDB" id="1033833at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="PTHR19957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="SSF47661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC95452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="35684" checksum="1352347B0702E8C8" modified="2011-10-19" version="1">MDRLQDFRRAVVGLGPSESPMELRGPVLPLPIAPAGSQEAETVAILENYFEVVNTVTESIEDIYHTLREMSRKHEQAMETINVEKCDAIRNEISEMDNNINESMQRACQGVEKMNELTKQLKDTPANECKFAGVIRLEENQRRYMFQKLSTVIETVQKQQLKAEKNYLSQTERRIKIAYTNPDGTTLDDDTVQQLATQVMKAGATSAIFQQSKDVLAQMLETRNDIYRIEMSMRSLNRLFSDMAILVEEQGNMMDVILRNIDSAKTYMEKSHEELRQARAYQQSSRRKLMCMLLISAVIIGLFVTAGLLGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4D2</accession>
    <name>F9W4D2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000543">
        <property type="protein sequence ID" value="CCD12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ITRCDAG"/>
    <dbReference type="OrthoDB" id="1576281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="34125" checksum="CB9EF2AE6518209E" modified="2011-10-19" version="1" fragment="single">MDTSPLNPYLLFSNADEFSTSGKVAYALRHPADRVSTEGLHAPRELREKSLISSVKDLERVMLPSKSHVQMVDTVGSQGVRDNFSTLPEGSKKKLVPPHVAAGGSAPWENESIKSDSENWNHARSSTDAWNRPVLSLYQQYTLLIAIDFGISSFCISEGGVVLVDNVPRAIEALLNVINTCLATRRSEMTQIKRWLQTHLEESEWEHILHRVWSPAVKVTIILINVPALDMTAASSPAHSAEFPTKGATFSEHPGDLHLFPETTQTFLGLKGAVSFGGAEGTSWIPLVTQCDAEEILHDTSFVRKLGKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J9</accession>
    <name>F9W4J9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1191</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_30080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000565">
        <property type="protein sequence ID" value="CCD12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30080"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394550" evidence="4">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="50"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24971" checksum="DA17BA93673F72BF" modified="2011-10-19" version="1">MFIKMKVLLPIVLFGMFVESGTSNGGNHNADESKLLCDVLRMARGILNNTKEIHKKDLKDAIYGSSETNYEFGEDGKVSGGSRCISQNLRTQLCTYNGQEGCYAQSLLGTLFCVCTPGGKTSTEGTLCETALANYGGKGWWDQSQEDARTELFKKVWAHVVEACHCLEEMEQTYDERLEALSTAVQKARKQIKNGVKSGSPYSLRGSGTGECSGTSIDSRVCGLYNTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4M3</accession>
    <name>F9W4M3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1204</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000579">
        <property type="protein sequence ID" value="CCD12117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30310"/>
    <dbReference type="OrthoDB" id="1700803at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22558" checksum="6F2151011C4DABFE" modified="2011-10-19" version="1">MNMGGEREAVPNWTMEGEVEQVLIQECSTQCKINLSYFFVEYYGWTVGEFRHLTFGELFKRPAERYLEDANRHKKVKKDIQHMLERLHDNTIKDVRYLVGDGIITLRDWALRGPGTLLDRVPRGNLDEAVREACKQPRPPITSGSMSVQRSNEASDKLAHQVAGNPSTQRQPGGTKDNEPEEILCGHASPGKTFALLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Q4</accession>
    <name>F9W4Q4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_30620</name>
        <name evidence="7" type="ORF">TCIL3000_0_49470</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000592">
        <property type="protein sequence ID" value="CCD12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001464">
        <property type="protein sequence ID" value="CCD14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30620"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49470"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007659363" evidence="4">
        <location>
            <begin position="24"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="26"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="97"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46538" checksum="622270CC8F47866D" modified="2011-10-19" version="1">MVCFINVLFVAVIFCSSVRYVEGNSAVVQSVDNAEQFALLCRIYNVAKNPPINHVDLQEPFKIVSEIDAINASFIEENQFNKTEKMGNSSYTHVKPTITREAAVAQAILRRINQKSHIILEKIRKLNVTRDFQKVKAEFSQVIFGEGKNESHLCDVVLKSMGDRGTACGKPGAGEKGSHAGKNLVVDFFCLCAMRKTDGIENVCGVYVGGTKDNYHGWDSNGPSGSSTMWASVKKGCGKLMHQHPISTEKGHEVLEDFVKHLETGGVYRWSDNSKVHGSNRKEGMLGTGMVKKGGDGADLLCDGKKGNGRSATPGGICVYYGNNDWDKKIDWLKQFKRALNTVDALNNKTATIQRDIEKLNMLLHRAEKIYETSRVISEVQNPVVQANFHTAAKRLTAYNAALRNQLHHFIATWVHFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4W3</accession>
    <name>F9W4W3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_05490</name>
        <name evidence="11" type="ORF">TCIL3000_0_05500</name>
        <name evidence="8" type="ORF">TCIL3000_0_31130</name>
        <name evidence="9" type="ORF">TCIL3000_0_31140</name>
        <name evidence="5" type="ORF">TCIL3000_11_13400</name>
        <name evidence="6" type="ORF">TCIL3000_11_13410</name>
        <name evidence="7" type="ORF">TCIL3000_11_13420</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 12">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in calcium-mediated signal transduction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000622">
        <property type="protein sequence ID" value="CCD12209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000622">
        <property type="protein sequence ID" value="CCD12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001587">
        <property type="protein sequence ID" value="CCD14626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001587">
        <property type="protein sequence ID" value="CCD14627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F9W4W3"/>
    <dbReference type="OMA" id="SCDRHPP"/>
    <dbReference type="OrthoDB" id="1386217at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039030">
        <property type="entry name" value="Calmodulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050:SF401">
        <property type="entry name" value="PTHR23050:SF401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC95834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC95835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC95836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD14627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16839" checksum="447DA4BB62170230" modified="2011-10-19" version="1">MADQLSNEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDQDGSGTIDFPEFLTLMARKMQDSDSEEEIKEAFRVFDKDGNGFISAAELRHIMTNLGEKLTDEEVDEMIREADVDGDGQINYEEFVKMMMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W524</accession>
    <name>F9W524_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000646">
        <property type="protein sequence ID" value="CCD12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31710"/>
    <dbReference type="OrthoDB" id="1711131at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20761" checksum="B120A55DF5B2FEB2" modified="2011-10-19" version="1">MRHRTATPCVTVSTLYKSHTSTQARSEQKRGVSPARPSNNKKLGWHKSQERAVPCESCRCCWSTLFVSPNSARAARATQRTLKRLDTRLTPETSTGDSSLHSSLLVARQQKRRSASHGNSTRGNNAFKSKREAATSAAALKERREYASNRHRSPIRAFIIPLVWPCRSLSVPSRRARLPPLKEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D0</accession>
    <name>F9W5D0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_32640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000699">
        <property type="protein sequence ID" value="CCD12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="KVTPQSH"/>
    <dbReference type="OrthoDB" id="1473625at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 8 9" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="8">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16748" checksum="8DAD0B3C5E33F15F" modified="2011-10-19" version="1">MQRSQLIRKFATRTGVYSFLRFRCNGTSMVRDRSIQLAPPAMQVSFRFHTEGQAPGEEAGRTGQYLLNKDDVLTRVLEVVKNFEKVDASKVTPQSHFVNDLGLNSLDVVEVVFAIEQEFILDIPDHDAEKIQSITDAVEYISQNPMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D6</accession>
    <name>F9W5D6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1316</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000703">
        <property type="protein sequence ID" value="CCD12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32700"/>
    <dbReference type="OrthoDB" id="128953at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="36977" checksum="1C89B8F5D7D0CBAC" modified="2011-10-19" version="1" fragment="single">MNVPWKVRGSVQASVGIISAIEFDPDVELLWVSDSFGRLMSFTTQSQTDTLSWAVYSSFAASTRPIFGIFFLKMGNEVIGTVADHNVVRGYKRGGAQCLYCTLPPQSQDHIELFQACSESSVVSFVGNVGLTRMNISSGTASDVVTVPLSESKTVALKQTSKWVITGAASGNIVVRDSKCLDVVASVPPSRHRVLAMDANDETVIAAVVERNMTSSVRIYDVRKTDEPVNSINGIPCDSVSQVRRYHDSFGLSPDRVFLLTSHGFHILQVDQATPVFSSKGLVEDNCTSVSVSPNGMCAAIGNDKGHFIALGHSATREDYVMSRFEQPKRPVNPVFTQSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5P5</accession>
    <name>F9W5P5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1354</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000745">
        <property type="protein sequence ID" value="CCD12497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33730"/>
    <dbReference type="OMA" id="YLMINRF"/>
    <dbReference type="OrthoDB" id="139828at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="785" mass="91984" checksum="974C3603089EFB7B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E8</accession>
    <name>F9W6E8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1452</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000854">
        <property type="protein sequence ID" value="CCD12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36070"/>
    <dbReference type="OrthoDB" id="1723458at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="17513" checksum="C0719EFC47EA91A2" modified="2011-10-19" version="1" fragment="single">MSWYTITSPRTIPWSMEKDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYFDMDDMPLEAIDEEIWSRCRRPPPVPPYQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6F6</accession>
    <name>F9W6F6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_03620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000861">
        <property type="protein sequence ID" value="CCD12761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03620"/>
    <dbReference type="OMA" id="QFYSKDG"/>
    <dbReference type="OrthoDB" id="1271788at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="2">
        <location>
            <begin position="77"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="22008" checksum="A48534A050C0E89E" modified="2011-10-19" version="1">MLRRPLACALVTVTHIRSMHGKPTQSHKVRTQHSRRWWTQSKARHLTAMPHDECKSRPHFPSYNEDVDRPMVVPDEVMCFNCVKPINGSDINSYVWIPAGNATVPTSQGYFFHFECFKCWRCKCRSMHNMLYSKDGKVLCVSCALGRDLRVPSLRRPACVRQHSPHGVTFDRTLLCRATCHQMVFISDSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H3</accession>
    <name>F9W6H3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1468</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000871">
        <property type="protein sequence ID" value="CCD12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36310"/>
    <dbReference type="OrthoDB" id="1718249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="16789" checksum="CFB67CDFC2BFA77D" modified="2011-10-19" version="1">MEHSLEARCQCMSATSSCRGGTPIPLRGGVGVVKCRKSLGAVEEKSATLLLGQGLCVTFPSAYYPVRLGFTRYPPGSLRSADGPTTIVADVGPGNRAWVPLTKPDDAGESTAQLCWNLRTPLRLQDDLRIFFHRVGCYGTWKTWSIKLAAGDETSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J5</accession>
    <name>F9W6J5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000887">
        <property type="protein sequence ID" value="CCD12802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="110" mass="11940" checksum="AFCE37FE14949B30" modified="2011-10-19" version="1">MVPGDGQKSLSSLKELPIPRKCVIDVPESSSCVPLYLCNHISIKNVPNLLSIFFPLLDLFIKILVGRGGTCLESQQAKKQADLLSSRLACSTVSSKRAIATQRNTVSINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P7</accession>
    <name>F9W6P7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_05050</name>
        <name evidence="11" type="ORF">TCIL3000_0_36950</name>
        <name evidence="10" type="ORF">TCIL3000_6_3720</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 13">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="8"/>
    <dbReference type="EMBL" id="HE575319">
        <property type="protein sequence ID" value="CCC91118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000905">
        <property type="protein sequence ID" value="CCD12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001388">
        <property type="protein sequence ID" value="CCD14102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36950"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_6_3720"/>
    <dbReference type="OMA" id="QCIVEST"/>
    <dbReference type="OrthoDB" id="945145at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="PTHR10836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCC91118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD14102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39021" checksum="F06F9B9489C0EEEA" modified="2011-10-19" version="1">MGIKVGINGFGRIGRMVFQALCDDGLLGTEIDVVAVVDMNTDAEYFAYQMKYDSVHGKFKHSVSTTKSSPSVAKDDTLVVNGHRILCVKAQRNPADLPWGKLGVEYVIESTGLFTVKSAAEGHLRGGARKVIISAPASGGAKTFVMGVNHGDYNPREHHVVSNASCTTNCLAPLVHVLVKEGFGISTGLMTTIHSYTATQKTVDGVSIKDWRGGRAAALNIIPSTTGAAKAVGMVIPSTQGKLTGMAFRVPTADVSVVDLTFTAARDTSIKEIDAALKRASRTYMKNILGYTDEELVSTDFINDNRSSIYDSKATLQNNLPNERRFFKIVSWYDNEWGYSHRVVDLVRHMASRDRAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U7</accession>
    <name>F9W6U7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 152</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000939">
        <property type="protein sequence ID" value="CCD12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03710"/>
    <dbReference type="OMA" id="ARWIRRP"/>
    <dbReference type="OrthoDB" id="1659939at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="568" mass="61297" checksum="25152A3044BE96D6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6W9</accession>
    <name>F9W6W9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1531</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_37470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000943">
        <property type="protein sequence ID" value="CCD12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37470"/>
    <dbReference type="OMA" id="INHVERR"/>
    <dbReference type="OrthoDB" id="685006at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="2">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="112" mass="12525" checksum="85D00B0B2448D551" modified="2011-10-19" version="1" fragment="single">MSVRQIFFTSEHVSEGHPDKLCDQVSDAVLDACLEQDPLSKVACETCSKTGMVLVFGEITTKAVLDYQKIVRDTVKEIGFDNSEKGLDYRSFNLLVAVEQQSPDIYQELGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z5</accession>
    <name>F9W6Z5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_03880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000953">
        <property type="protein sequence ID" value="CCD12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678332at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="19"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="296" mass="31570" checksum="F34D7ACA29961FED" modified="2011-10-19" version="1" fragment="single">MLSAAYGEEKIVLGDSTKEAITHDQLDKVSAKEESFDQTDSRGLYAAQCSGAKVGKNIVSDITCLCALKTDMNNDHNLCVSAGGLTSITSGNKKMDVKGEPLVIWNAHKQTCLGSALTSETVTKEELLGILPRHRSMLGKGALFSGSPTQGDHAKKSNFFLGKHAINPSSGTPTCDGSGTWAAGNKGVCVDYSTILIAGDEIPWVSQIQQAVGKLNVIERKFQSEVFLFQNLERLEEVAETVFETMVNGATSQANKPPGETSESNQIGAGTSKENLAKALQTEGLTNQNGFSYIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W711</accession>
    <name>F9W711_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1547</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_37880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000960">
        <property type="protein sequence ID" value="CCD12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37880"/>
    <dbReference type="OMA" id="PVRMYCL"/>
    <dbReference type="OrthoDB" id="1528533at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006480">
        <property type="term" value="P:N-terminal protein amino acid methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="PTHR12753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="250" mass="28127" checksum="2E0DC316FCB0EA31" modified="2011-10-19" version="1">MSAHESTPTGHNIPGVDTEGRSYESAEDMWNVELNGDLYDAKSGWYGKSLQYWEAAPTTISGVLGGMDHIHDVDIRDSRDFIHSLPDRGTHRALDCGAGIGRITKSLLCSMYDITDLLEPVKNMIEKAREELKGLPVGEFILSSMEKAKLPEKTYDLIVIQWAAIYLTDADFVAFLAHCKQALTSKGYIFFKENCTCDDKFIVDKEDSSLTRSDKHYKRIFSAAGVEVVKEAMQSDWPEDLLKVKMYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W754</accession>
    <name>F9W754_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1572</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000988">
        <property type="protein sequence ID" value="CCD13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38330"/>
    <dbReference type="OrthoDB" id="1706515at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394731" evidence="1">
        <location>
            <begin position="19"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="21946" checksum="9585CF962940810A" modified="2011-10-19" version="1" fragment="single">MMKLFMVMVVVLCVCASADEKNVPLSAVYLFFPIPISPFPETSIKIPMSLYTITSPNQRPWSMEKDVVDVLLDGVTYADRINLYWLPRPVLACLPVDLVCFTLRDFVRNPRHCIPDANVCDSLWQYLPYLLWKFRQSAIPLVKHFGPTQTWKKWHWDSWKIYIDMDDTPLEAIDREIWRRCRHLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7C4</accession>
    <name>F9W7C4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04160"/>
    <dbReference type="OrthoDB" id="1666277at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389897" evidence="5">
        <location>
            <begin position="17"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="79"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="44087" checksum="57FE25793E4E5DBA" modified="2011-10-19" version="1">MMKLFMVVMMVMGGWVREWGVMANGEVSVKEGDNREPFKLLCRIYNVAHHPPIKPVDTKEYQKMVDDINALSAAANGKERVNTQTEAVTSAQTQLFGITRDAKKILEEIKRENPEGEAEKAKNTFNQVIFGKNGKEDLSQGGLEVVQNRITACGGKEKKGTSAGKNLIVDFFCLCAKHDEDNEWVDKVCGVSVGSGKDSGWGRNFHPIATMWDEVKKGCGTFAKHGVTSTQDGYSLYHMFLAKVKAWGVVKLKDSATVPKHGMLGTAVSTNRDTNFHCNGKKAASTASRVDVGSGSCLFYGNHHREKNIKWLSQFKAGLQLIDQLNTETAAWQHQLTTLLNRARELYEKVKANTQLEEENTDDSPLAQHPNPDENENADSTTRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7D1</accession>
    <name>F9W7D1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04230"/>
    <dbReference type="OrthoDB" id="1713575at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21074" checksum="18D68B1C237AD1A5" modified="2011-10-19" version="1">MSWYTITSPRTIPWSMERDVANVLLEGVASPDRINLYWFLRPVLACLPVDLVCFTLRDFVRNPRHCIPAANVCDALWQYLPYVLWKFRLSATPLVKHFGPTQTWNEWHWDSWKIYYDNDDTPLEAIDEEIWRRCRRPPPPPYQPCQEVVVVEAAPAFIQVPYSTVGYLVPMPVSPGSRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7H0</accession>
    <name>F9W7H0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1611</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001032">
        <property type="protein sequence ID" value="CCD13136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39160"/>
    <dbReference type="OrthoDB" id="1742108at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18794" checksum="8AED17B216228D24" modified="2011-10-19" version="1">MNCPLLALIVFSHCSSPTARSLYRICIPILITDIVCVCVFPNSLFPLFLSFVVWCVWESSEDNQRSGGRLTYPLTATATRIAAWRVVSKLFAKRIVALLFLLFYSFRYFLLLFSLISLSLFHGACATRAVAMTRHALTFQGLSPSWWPELTLACTIVTFTHCFCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7H6</accession>
    <name>F9W7H6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1612</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001034">
        <property type="protein sequence ID" value="CCD13142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39210"/>
    <dbReference type="OMA" id="RETHEME"/>
    <dbReference type="OrthoDB" id="1456416at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="53418" checksum="46B8684003653428" modified="2011-10-19" version="1">MESGITSQRGENDVCLTNLDVYRELTALHELVSETALEARQSTAFCQKIQRDISEFVRSEELVRDRGHALAAGSSSGDMECSGSIQSHLLTFERYIIGRVREELHGAGLTPKSEEQVTRIDALEERLRNHEAKVEALAKEGAAQQTAMRRQMKRYAVDLESHVVNVEKALQAEGRVRQRYLDEGEALGDMLHNLAHEVLGALVQLSDGLGLERETIRVERNRWFSLMNRVVERVKLLEDHNAALTIELNELRAAGSRQSQKLQETSESVAALVRGVDSTWDSSPMQSVGECELYAFSEVEAIDGEGLRTVRREIARINKALSALRSDCRRHDIELERNTLQLVELNDAHRALAGNVAKIWEQAKLVSEDIRNNLNEPHHVFACKYEKRVTHLFGTYGSDVLSGGTGSRSVRRMIMQLLWEKTRRTARSNAFHLWISWVRGCTQFRRDQTVLGLFTKHRKQLNDMSRLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7J7</accession>
    <name>F9W7J7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001044">
        <property type="protein sequence ID" value="CCD13164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04300"/>
    <dbReference type="OrthoDB" id="1292381at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="SSF143503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23709" checksum="CF9A4543736B61AD" modified="2011-10-19" version="1">MSLEEAERILVESPPDPLGHAITRVFRPLLANILLDNENHKFHVVRKNNKLIKSVLQRLPESVVQTLFDAIDFKLECRNDSEMIYTFGGDVQKLSMSDNFFSYIEEKLRERRLGTSRFQPPLASRVELDWKERKDALIQEIRRDIDERRRDINESRLAKAQDALCHDDFTSVESLKEKSRLPLLNRGDYATHFLVVNIFHFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7J9</accession>
    <name>F9W7J9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 162</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04320</name>
        <name evidence="2" type="ORF">TCIL3000_0_06600</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001044">
        <property type="protein sequence ID" value="CCD13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001993">
        <property type="protein sequence ID" value="CCD15641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04320"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06600"/>
    <dbReference type="OrthoDB" id="1681921at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="29890" checksum="BB9E418543BA2C26" modified="2011-10-19" version="1">MDHHLPSHTGPHFLSRGAQRGILKNVPPQSGSDWLPSPPLVESGFPAFASPETRIALGRSATSLSPLFDTCWTAPIVHIPKWTLSARPARRGIRVGEPTAPETFQPVDVSVSSSGACVLTALPVLLPSVFPYHTQHAPGFLPLVKSQESLHEPLLAPWTPRAFPHVALYDASIQKPRLFLCRFGLCCLDNDVATITPSLIIAPGSSHFRASLEMSPLWVSSSGPLWHRCIASRSWVTLPHKLLHFLSVITLPGLQVCGGWVHDPRHPAANGTTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P2</accession>
    <name>F9W7P2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1635</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001059">
        <property type="protein sequence ID" value="CCD13214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39840"/>
    <dbReference type="OrthoDB" id="1665318at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="23661" checksum="2EAA5AEA29D797D1" modified="2011-10-19" version="1">MVSEGVDKVCGVSVGAGKDSGWGPKLYSTATMWVEIRNGCEKFAERSSTSTQVGHSLYSEFLEKVAEGGNVKVKGSGTGPKTGMLGTAVSDSKNANFNCNGQSSTNRFSGSGICVFYGDNKREDNIEWLKQFKTGLDIIDKLNNKTASWKNTLHTLKSRAKAIYERVMESSQLEKEDTEEPTQAQRLLSVENATTNNTTRSHSDHGRLILPWTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7R8</accession>
    <name>F9W7R8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1646</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_40090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001071">
        <property type="protein sequence ID" value="CCD13240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40090"/>
    <dbReference type="OMA" id="LTIVSHY"/>
    <dbReference type="OrthoDB" id="1167574at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="318"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="410" mass="46845" checksum="54ECA15B1055BABE" modified="2011-10-19" version="1">MVVMHEGTRGMNNLPSYFEKIVLTLLILLSFCVMLALVDRFRFFSSHRAGAVPLVRRYRVGEFEGWGILTIVSHYFLFLLLLFKLSRGCVRPTFPIMTGSLIRDIEETRRFVEEWYLLCIMRLRNARTAVDRHFNCLENLLNESVSSPRHDDNKFVDSLMVTPSRPTATVEDKSHCTPSMASPPVSRATLNYDRLLDEVDAVARIGSNISQDVLSIWQGGGVGDDVLGELSHKRPTPELIPEDKRNCPPPTNSASPCQVVVMFKRMRILQFESPTYVAPGEYVVVGGDRGEDIGLVTQSWVLDERDSNGEKKWAEGVGRVLRVASTLEISQLQGVQTELEDRAVEVAQKKVEEHGLPMCIVDAEYQFDRKKLTFYYRSHQRLDFRVLVRDLYKTFRARIWMEPDTPPQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7X3</accession>
    <name>F9W7X3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1671</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001098">
        <property type="protein sequence ID" value="CCD13295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40630"/>
    <dbReference type="OrthoDB" id="1702072at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="28680" checksum="E92E5FBDEFB8AEBC" modified="2011-10-19" version="1">MQNRTHIPVRSKKFTHTHFTDPPFFFAAATSFTPFSRPLPTLNCTYVPALPLIRRVNFSPLPLAWLPHVYDFVSLYNIISSSSLSPASQTHTKNDARMLTGTAPYYFTPRNHNGNLFLLFHLPLACTTNSAPFAHIVTSSCRPHTHIPNEAQNKTIRAKDHVNIHIWRTTNPITTNCGAQPSFLFPLVLKKKETKKNIHKFNAKKTLPLCPHISTNPFHPAHKRILPPPSHRTYLSGYSSRRSHPKESASTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W876</accession>
    <name>F9W876_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_41550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001146">
        <property type="protein sequence ID" value="CCD13404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41550"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394766" evidence="4">
        <location>
            <begin position="21"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="83"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="49136" checksum="4E202773663BDDF6" modified="2011-10-19" version="1">MVIVKLSLVALVFCAGAALSGKKPPSAKEFNLFCRILRVANDMMVEPDYVYDENTDRETLKEMEVLYNATTDNMNDFRRTLWDMKDFLKEHPPPIRLENRRKAHSEIKKLIIKAEREITENREIAVEVNKEKDAAKWLVLQGMYGDNVKDVPREEGAWTDMRNNSENIFVNNTSAAKSCGNESKAGKTIFNDFFCVCVGEGVEDTEGPCHPGIMAPKRALKSNKHCYEDANSDNCTKWTEMKHHSSSIPPIPLVQAIGKIEQQCRIEIGKEEKVKDIPNLLKEFIELIGVGEAKDGTNAKNIFGHSGRLKKNGNNNVNQCTGVGITGDKDQPDYHNDRICVDYTKNLKEGKTYEIPWHNRFKEAFDKMQEAKKIEDKIFQNHADILLLKTKAWTAYSIEKDDETINLDDMNISSIFEGAQLPPLFPFIFLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L1</accession>
    <name>F9W8L1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1744</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001180">
        <property type="protein sequence ID" value="CCD13545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42870"/>
    <dbReference type="OMA" id="RFLMMDL"/>
    <dbReference type="OrthoDB" id="95721at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045208">
        <property type="entry name" value="IF4G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="PTHR23253"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="2">
        <location>
            <begin position="202"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1129" mass="123955" checksum="3449DD4B8E0C5C18" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8N5</accession>
    <name>F9W8N5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1753</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001190">
        <property type="protein sequence ID" value="CCD13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="QVQYYEQ"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="4553"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="4553" mass="582719" checksum="1B5FC7AE692A34CE" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8T3</accession>
    <name>F9W8T3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1774</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001213">
        <property type="protein sequence ID" value="CCD13619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43570"/>
    <dbReference type="OrthoDB" id="1671356at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="40605" checksum="D0B4CB72782343FC" modified="2011-10-19" version="1">MCHGKKPLSSRIRTRTLPHMMCHGKKPLSSRIRTRTLHRVMCLGKKPSGSPGKKRQGGRIRTRTFHHMMCHGKKPLSSRIRTRTLHRVMCLGKKPLSNRIRTRTFHHMMCLGKKPLSSRIRTRTLPHMMCHGKKPLSSRIRTRTLHRVMCLGKKPLSSRIRTRTFHHMMCHGKKPLSSRIRTRTFHHMMCHGKKPLSSRIRTRTLHRVMCLGKKPLSNRIRTRTFHHMMCLGKKPLSSRIRTRTFHHMMCLGKKPLSSRIRTRTFHHMMCHGKKPLSSRIRTRTFHHMMCHGKKPLSSRIRTRTFHHMVMAKKVFSHPKDTGGYFQAFDENDFFLRLFGCWVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8W1</accession>
    <name>F9W8W1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001229">
        <property type="protein sequence ID" value="CCD13647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43850"/>
    <dbReference type="OMA" id="AVTLQHC"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="362" mass="40120" checksum="75C951178C2337E0" modified="2011-10-19" version="1">MRHNLYRRFLEVRKHWWNTCFQGNAQYHCPACGYANPQEAVTLQHCREQHPQEGRLQPYSLQRDTDKVQFVGPSCAVSAVVSVLSHLEEEKKSFHPMVRQCYTQPSRQATQALVQGLQLSLPTAPATVLEALGSVDPGITRCFQAAMVQAWQCRRCGRSEGNMQQQGARPHFGLLKVQPTRHAPIELSHGQLAAAYTEEVLDPTVPCVGPLGGPAHHPQATALVTARTFGDAVALEIGLWGEEQVGLKRIPADILLPHGNGSATYELVGAVIAATPTHVVAAIPRTVKKRRRWDIIDGMVKHTVSDATVDPRKVVLCIYRRQEEERRALSNDTLLQHGLVRCDKCSYIIPASDRARATHVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W905</accession>
    <name>F9W905_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1807</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001249">
        <property type="protein sequence ID" value="CCD13694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44280"/>
    <dbReference type="OMA" id="ITESLHH"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394617" evidence="1">
        <location>
            <begin position="44"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="115"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="671" mass="74612" checksum="3D80F8101154F1B1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9C1</accession>
    <name>F9W9C1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1846</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001293">
        <property type="protein sequence ID" value="CCD13817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45150"/>
    <dbReference type="OrthoDB" id="1724741at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="18245" checksum="66360A6FB6B2CA9B" modified="2011-10-19" version="1">MDAEGAYFLIKHFEHTTGTYILYFYMEYKKGIISAFRFFTHGTTSNQPEQLKEGDKRLEKALEDIRHGLKDFYYNIVKDNLFLGGRRIRALRDFASNLGALYIAVTREVALSSAVRSKRKRAVIHQQWKPFFQMEKRAVITPQIEEPAIERYDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K5</accession>
    <name>F9W9K5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45970"/>
    <dbReference type="OrthoDB" id="1762217at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="18514" checksum="FFB5B434BBFA27B9" modified="2011-10-19" version="1">MIAVQITFPSLPFFFLIFYMQRKEKKENFIAHFFFFSSLLFLVCPFFVFFSLFSFVTFPTHAAQHSEKYKKNYFAFPPPPHTQNTPQRLHRCTMESATRPARTRARTLNGGFFFSFKKRRRRKKKRRCDLAPNGKGKANKQKKLGHQAYWRLVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9R4</accession>
    <name>F9W9R4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_46530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001339">
        <property type="protein sequence ID" value="CCD13969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46530"/>
    <dbReference type="OMA" id="MTNYMAD"/>
    <dbReference type="OrthoDB" id="1138539at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="Mit_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="PTHR45635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="14"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="7">
        <location>
            <begin position="250"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36303" checksum="4C951CA87EA034CD" modified="2011-10-19" version="1">MDYEQVRESPSSVRDSLLDMAAILIVSFAQRAVMAPSYRVTMLSTVEGELVREGRLPPTGFGGVFACVRRLYVNEGLRSFFRGLLSDAVLSVPATIVENLCSALVSYALQAVVPLRHIETMNPWTYLTLSLSSTSVAVLLGTPATGVHNTIVTNYVADISAPNLPEKDNKAGGNAEEEKDGVVAKEERGCDQVWAYRYATATETAKDIYRRLGCRGFYRCIGADAIAVFLYRGTYYYGSQLLPSALHARYPYGVSRCLAVIAGCITQPIEVVSRRMQLTASSTKGRRYNGMLHCALTIVAEEGYMALWAGLRARLLVTCLGVAVMELRHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U6</accession>
    <name>F9W9U6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001351">
        <property type="protein sequence ID" value="CCD14001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390012" evidence="1">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="107" mass="12043" checksum="B4492D6CA27E95E5" modified="2011-10-19" version="1">MSEPSLLHRLVPCSFLVLRIFLLRSTAVYRGWCPPAGCVVRNNLQRVFPCVRSHPDRRYGLMSILQTWACSVELISNGSTPRSEGTRSHRKLQDLSLLSAGAYSQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9V7</accession>
    <name>F9W9V7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1902</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD14012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1705308at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD14012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1907</fullName>
        </submittedName>
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    </gene>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001360">
        <property type="protein sequence ID" value="CCD14026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47060"/>
    <dbReference type="OrthoDB" id="1724332at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="33"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="21499" checksum="6A7A0A65F27C7C4A" modified="2011-10-19" version="1">MCRPILRRFLGLFPSTFTSSSCTPFLLPFFTHFPLFLYVGKLGLRRWPLRPSVVWMFLLHVMNQLFVMVLFATYEALVSGWLLQFSRVVLTPIGLLYALVSDAPCYALHMLTLWAFYCFLILVNFILTRIRSLVNDIVLFWLSLLYGFFACVCLFGLPYDECFLQHQRYFSLTMSAFSPSPYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA31</accession>
    <name>F9WA31_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1924</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001380">
        <property type="protein sequence ID" value="CCD14087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47540"/>
    <dbReference type="OrthoDB" id="1666453at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="123"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="405"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="115"/>
        </location>
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        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="543" mass="57623" checksum="3CA0B0BE861D3B27" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAB8</accession>
    <name>F9WAB8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1952</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001411">
        <property type="protein sequence ID" value="CCD14179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48270"/>
    <dbReference type="OrthoDB" id="1663666at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="439" mass="47587" checksum="D19590D2DFD7A675" modified="2011-10-19" version="1">MGVPFCGFPAGLVEALVSPSVVKIVSDQSTRFCSHGVAQPDGFSDAYTLLSTHLKVDFQCVCSIHQLALFVGLPVPATPNPGQLRLLYYRLITRGEVAVPPHLTPSLLGVLCAALLAGVYQSDGHAFDVNSFQQLLRDAANGGDALMIRNMRLRIERYGVRCAESLSRKSCEIMLQQLLSEHGPEICFMDRLTNDLRTIPGATDAVVSGQLQVQDGDEEYIGELLRDDCSSTAAGSHDEDMEQKEAPITDDVPISIKKRTVESYGVENGDNSVMKNTEKPHKTPIHCRETASPEQGTGVPLTRSDGVGSNGNFELGNKTVEFVLSPPGFSQNFEKKSMGKGSVPLTFSKRQHNRPAALTEPRATGDFTSPALRPSVAMEGDTLTERCAGRTDGDPKHIESDGAFIERLTREVLMDTMEKQCAMVSRPVAGLRLALGKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN0</accession>
    <name>F9WAN0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001457">
        <property type="protein sequence ID" value="CCD14301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1579717at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16778" checksum="EF127DE51A4FC318" modified="2011-10-19" version="1">MWANATWEQRASILRKLCEFSEQNHLGAREENVPSFFESLQLTKSSGVQYTRTLLGLLEAGRTPAQMSLAVLQQRAVNVPMKQARPMENWKLALMSNTPSFKCGRVALCLARAALGRPDEIALFQEENFISHQAVTRQLFRELKTTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAR5</accession>
    <name>F9WAR5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001471">
        <property type="protein sequence ID" value="CCD14336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="14243" checksum="445A24A6BB6786CF" modified="2011-10-19" version="1">MPSIFFVNATMCHHFSFIDKNGQGKRKRPHNSPDGVLLDDFLKSWLPHPQDKQHPPTFSTINMSLQRRAAISWALLFRVTDDLHVHSGQRNDSSLRNHRHQPRPLDNWNTLAVRHHCNHVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAR6</accession>
    <name>F9WAR6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001471">
        <property type="protein sequence ID" value="CCD14337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49700"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394641" evidence="5">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38270" checksum="A1A7C90E221484F8" modified="2011-10-19" version="1">MIKFGLLLVTVILVFVESEDMRDYNKDDYKLLCDLIGAAVKKWGEVRESGGPLRDALKRTLFGKESENNDLSKLNFPEDYTKKVDGDLKNSRKHWCGGCTEVGQKHHPGESALHDLVCLCAPGQYGWPISGDDEKKLCGKNQSNWILTGGEMKGWYTVFLGEKDQEREQMSETWETIIKDCVRGGDGNDLQTALQAITEKTRKVGVQYLGKHGSGYSCGGTAGDGVCVRYPPECVRNTWWKELEDAIMKYKEESEKEDTEQKKSESSEKGQKLKASKGEHKAQRQSSHSPQPASRVSFSPQTEGDTPQEAEKLISNITGKHREDSSLLTMPQRFLWAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBA1</accession>
    <name>F9WBA1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2080</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001552">
        <property type="protein sequence ID" value="CCD14532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51400"/>
    <dbReference type="OMA" id="WDSIELF"/>
    <dbReference type="OrthoDB" id="596302at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="413" mass="46000" checksum="C0531FEE411B84E2" modified="2011-10-19" version="1">MLVVFSSALAGFSRRIDWTLTCQRRFRISEASHTIGVIDLCSKSNTGLACVWNETDNWCSLCCEPVNSWNEHRGKRDHICLEMFYNAIVQFGRRWSPTTLWWEVEECALLRRCEAPRPLQPFDQDVVCNRFVDFVCAPTENKGGVSLLMGCYDRAEHYTRRLGLHACLRHLVDNGVVRTDRASLSGGASFHGSLVTFKELFPGLFNMFPFADAKEISALTQMIASTYNSETVFDLCNFQQLFSVGMEQGTAGTANDNDARGLQSVSHGTGQGGGDASPANASGENSFHLKGVFCRGVMGQLRWALECDSVACPLQGACGCHRELDPYWQVLSEHTCRALLAEMVFCRVSEYIVRVEGVWRRRGALPGGLADETHPRRLSNWGHLQYMGAELFDETFGGRLLNEGAPKKLPTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBE0</accession>
    <name>F9WBE0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51750</name>
        <name evidence="4" type="ORF">TCIL3000_0_51760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001566">
        <property type="protein sequence ID" value="CCD14571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001566">
        <property type="protein sequence ID" value="CCD14572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51750"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51760"/>
    <dbReference type="OMA" id="YLEYIGP"/>
    <dbReference type="OrthoDB" id="1666511at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007659368" evidence="2">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="47165" checksum="A79E4EDF8CFCF6C8" modified="2011-10-19" version="1">MRLKAIFICVALLIDFATSSTTGQGNEVVQHEAEKMLDRFGASALCTMKVYCDRIVSDTAEYLVEEIGYQLYLIKSDIHSINHYTGEINRYFGDLPQDQQEKVMKACEVALNITKARREIAEAAKKKAEDLVLNATLAANLTLGEIGEDEDGNATVDNTTGLARVINWHCGYSKVENETEPPSTSCHVVGKRKRFSGGFRNTISCQRLEKSVSYKNATAENMRRALMEWNVVKPMPKENGKICQDTDDHTNHSCTVWEGWVADYKKTTDLMKKLGGAERRARRARLQGEVEVIGLYKIYQALRAGEESDVIELLLEEAEEKRMLANEAELVSGVLVTRGSDKMSLERDKDLKLLKQARTETPKGMSWTMVAMISSLPVGLALMVYIISRFRKMPENGKDDLISPTCSCSLTNVGVEGDLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBJ6</accession>
    <name>F9WBJ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001588">
        <property type="protein sequence ID" value="CCD14629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52290"/>
    <dbReference type="OMA" id="PSYISHA"/>
    <dbReference type="OrthoDB" id="1550369at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="36214" checksum="B486B101A5564C77" modified="2011-10-19" version="1">MGDSLVDKFIADVLRDPNAWKRAVACVDSRSRYSEKSGAIRSVAGPLFRRGTNENVSSLKFLDMLRRDDVEGVNARAVTVARTDVRQQWDNSKTIIDEQQDLLKQLLVRKLNRHGFFVSYQSSKAKLLEKHAREMSSRQQRYADIVVTRNIKVNSRQREHVIVKERNERQFVLEQERKARRTILRRFAKQSTVVVENEEFVERREIFRELLEVYCAIKAIMDEEMYLLTGIRPEDQHAFFAIQHMEAKERHEIIARFESQRREMFLQLQKRLKNTIQNEIKRIIRREQQIQELHRQCGYLKIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBN0</accession>
    <name>F9WBN0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 212</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_05540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001599">
        <property type="protein sequence ID" value="CCD14663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05540"/>
    <dbReference type="OrthoDB" id="60233at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="3">
        <location>
            <begin position="367"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="568" mass="64095" checksum="7BEB39FDDCD9FCAD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC18</accession>
    <name>F9WC18_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_05630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001654">
        <property type="protein sequence ID" value="CCD14805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05630"/>
    <dbReference type="OMA" id="WIMFASI"/>
    <dbReference type="OrthoDB" id="1319375at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394664" evidence="2">
        <location>
            <begin position="28"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="559" mass="60176" checksum="BD599303ED26BE88" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC50</accession>
    <name>F9WC50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2185</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_54190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001669">
        <property type="protein sequence ID" value="CCD14842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54190"/>
    <dbReference type="OrthoDB" id="158628at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="25455" checksum="5330C74F398CD07A" modified="2011-10-19" version="1">MTSNNVDGAAGVAPGASQPGVIRGGRDAGIFTVDDVADALSDARVSHRNDENIVTIPNVVPTKSFNHHAWRRNEERPKLHSSHLRCAYCSGRHHVTQCSKLFGNERRNGEMSYDDSAGDIEPAKLKGNEDRLFCIKCGQHGHLYAKCPKLPVGLHTSVTCPICLLSRSKTHHNPSQCPRRVSAPVDYTPSGIPLSMLQPSGNEKRKGSARRRAMASSDQNVLLSDSFLLHSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG0</accession>
    <name>F9WCG0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 2228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_55210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLUAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001718">
        <property type="protein sequence ID" value="CCD14953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55210"/>
    <dbReference type="OMA" id="DHHRLEQ"/>
    <dbReference type="OrthoDB" id="874966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019366">
        <property type="entry name" value="Clusterin-associated_protein-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21547">
        <property type="entry name" value="PTHR21547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10234">
        <property type="entry name" value="Cluap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="471" mass="52681" checksum="9A674178E2BD840B" modified="2011-10-19" version="1">MSFRELRSFAETMRLLGYPNLISMESFRNPNVELVADCLFWLVKRYEPSAEIVYEIEREADRVFFFKQVCEVALTKGRVKLNIKKLYQSDGNAVQEMLILANILKKAMNTTALEELDHSSLQQMIAQRNVQDAKRVQQLCSDLTNDGSSLFFLIEEETKQRSDRQRVLSRATEVGEFERRLRDVLKNVTTQVEQLQATIVNLGADETTLEQKIESKKTQLERTQKRLKSLNAVRPAFMEEYEKHENDMHSQFVIYLEQYRNLEYLEHELSKFNAAEDALLEEHETKLRVMRERLRKEELNALRGEASRKRGSRSEGDAGGYKGAQANGRDGSSGSGNDRNGRAGERMRDAAVEGSSESESGGESQEEQVRPHGALGRPRPAAAMPSGSSARATLDAYNDSDAAGKAARPGMSMRANSPTERNVRGISQSGAGMSDDDSDSSGDDDDDSDIDTSDISIDSDDSGTDSSSNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP9</accession>
    <name>F9WCP9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_56100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001751">
        <property type="protein sequence ID" value="CCD15044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56100"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388978" evidence="4">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="39"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20814" checksum="9C625C2E3B556214" modified="2011-10-19" version="1" fragment="single">MWEIAFLPVVILSDSLLVMGKGDNVGYNNKTKELLCEVYKTAERVLNTTSSTYEHLKEDIEVALYGKKDRAKFDKDGNVELHLNCANTQYSRSLFCNYYKIHQSLRGGSRGDGCFSESLVGTIMCVCSPGDNVGNSLCGVSVTEYNGRRWSGMWSGSNTNSYLFKDVWEKVIGKCKESVIDKSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT8</accession>
    <name>F9WCT8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine protease</fullName>
            <ecNumber evidence="9">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_56490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="9"/>
    <dbReference type="EMBL" id="CAEQ01001761">
        <property type="protein sequence ID" value="CCD15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C54.007"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56490"/>
    <dbReference type="OMA" id="FSIHNMI"/>
    <dbReference type="OrthoDB" id="431748at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="PTHR22624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="327" mass="37087" checksum="1489D09B69505F38" modified="2011-10-19" version="1">MEYVQRLFQSVTDIRAEIKYPCNILGCVARDVQEVDALLERYFYLFTYRKDFEPLPRSVITTDKGWGCLARASQMLLACALRRHMTLDFSFQYFCDIDDERIAPFSLHCMVRSVLRPGEDLRPVYWTPSQGCEAISGCVRSAIHRGALHSQLRVVVGAAGAIPKHEVNRHLEDSGNALILVPVRCGTTRRMTQKMFLSLEHLLLTPMCVGMVGGVPGRCYYIVGTGGQELLLYLDPHCMTQEALVSCESDTAGVVRPTPRHLLCVPYDRVDTSFFIGFFVDSFELWEDLQKKIEGLSRQLLHRIVSLYSDNLPDPPDSMLVEWPTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCZ7</accession>
    <name>F9WCZ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 2298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_57050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001795">
        <property type="protein sequence ID" value="CCD15145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57050"/>
    <dbReference type="OrthoDB" id="1680078at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390161" evidence="8">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD15145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="282" mass="30935" checksum="6552A6F43B2B8AA1" modified="2011-10-19" version="1" fragment="single">MEIGSKLWFLGVILILWLETNLCNARRAIPTKAGSAICTLSKKLKDVTPWVTQQLDEEVTKITNLELKLLEWQSKFLQSKAQGRDYEACRVTGLLFRQMRKEVDKARAEVEKLEREATKAYTFASNSAGRLDEFITVFANAKTESSTKYCLGDTKPATNEELKDCFGGTDFSEGSLIDISENAREQDPNVGAAIEGIKYSRLSSHFTGASSTDGGCNFVKGSKNGVLENVGLEKSLWWGGGILTISKGFEGGINDSSFGPGEISSTQFQRTAVKHIGQQTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD52</accession>
    <name>F9WD52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2321</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001821">
        <property type="protein sequence ID" value="CCD15203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57480"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="707" mass="77764" checksum="9482DAAB74FC7800" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC2</accession>
    <name>F9WDC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2351</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001854">
        <property type="protein sequence ID" value="CCD15275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58100"/>
    <dbReference type="OrthoDB" id="1687242at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="250" mass="26920" checksum="FF45287A9614F73E" modified="2011-10-19" version="1">MHLCTGTNYSGRTVSVLPAGTVSWVMHLCMGTNYSGRTMSVLPAGTVSWVVRLCTGTNYSGRTMSVLPAGTVSWVMHLCTGTNYSGRTMSVLPAGTVSWVMHLCTGTNYSGRTMSVLPAGTVSWVVRLCTGTNYSGRTVSVLPAGTVSWTKCCRGLRSSYGSNGVVIVIKVVVTLPWGIMKAGWCLTAMAIIFSSGTPKLARRRRAGSNRVPRVTINVRGCLIGVPLSPVYKRPKLNDHHVVCLVIYRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDD4</accession>
    <name>F9WDD4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2354</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001858">
        <property type="protein sequence ID" value="CCD15287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58180"/>
    <dbReference type="OMA" id="SHWQVVR"/>
    <dbReference type="OrthoDB" id="1655365at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="734" mass="83763" checksum="11CA97169FB90FB1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDH3</accession>
    <name>F9WDH3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2363</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_58560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001868">
        <property type="protein sequence ID" value="CCD15326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58560"/>
    <dbReference type="OMA" id="FRWVAQY"/>
    <dbReference type="OrthoDB" id="1168548at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="PTHR45684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29736" checksum="999647149C643C22" modified="2011-10-19" version="1">MIYAVIEALYFLLHFTLHRGICDLFEDCLRCLTLPYSFPFSIALLQYSLFALHRFTFDCTSCRQAVEVMGLFSWFWDMLSFLGFSNKTGKILFLGLDNAGKTTLLGKLATDQVHVHRPTFHPNVEELTLGGIKLKTIDMGGHLEARRLWKDYFTKVDGVVFIVDAANPERFQEAKQELDMLLQTEELSKTPFIILGNKIDMPRAVSEEQLIAAMGLTGLSTGKQNKVTDPAVRPLEVFMCSVVKKVGYGDAFRWISQYLQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL2</accession>
    <name>F9WDL2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001884">
        <property type="protein sequence ID" value="CCD15366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58930"/>
    <dbReference type="OrthoDB" id="1674281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394692" evidence="5">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38800" checksum="54CA24AE6AF11F96" modified="2011-10-19" version="1">MMRMRVWMVVMVFFGVAASADERDHNGDQHKALCGLLKAAVDKWGEVEKREPADPLRKALGRTIFGRVDGGILGDLKGLPKDYNNVEGTADSRVTWCGNPYDTPDFFNALLRWSGHSAPHGLLCLCTVGEKGWPLNESDNKIEKLCGLGKESLAAEDIKGWGYTKHEGNKHVTATWTAIVTPCLQSSGMEDLKQALKTFLGKLVNKSNEWYTNRYQLGEGEPSMYDGCDGSEKKGVCVLYYNTTATNKLMPWWVDLQNALTEEEKFQEEKKKREEEEKRRQKEGEQITDEPHAEVLKSASTTPNQTEQNKHDSNLTDKIRKLNLTRSSSITRPTTWLLTTIIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDN2</accession>
    <name>F9WDN2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2383</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001890">
        <property type="protein sequence ID" value="CCD15386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59120"/>
    <dbReference type="OMA" id="LYYENEY"/>
    <dbReference type="OrthoDB" id="1230314at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="559" mass="60847" checksum="B7EC731E02A18E67" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDP0</accession>
    <name>F9WDP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001893">
        <property type="protein sequence ID" value="CCD15394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59210"/>
    <dbReference type="OrthoDB" id="1096950at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="42505" checksum="89DE5E660D553377" modified="2011-10-19" version="1">MPMACADLVELLQVCVRGAMAAQRYIILELLQLDSSDAPRRDVRIADFEPQSLRMLRDRLRHVVTVGVKGQLAHKEGTAANDLVTTADIVTQTVLERALADAFPDMPFTLVGEEDANTSAAIASQVDDCMRRFLVADFPIPLQADLNRHACTESRLICAETYEELRSRIGVFLDPIDGTNCFVDGHWTAPLTLVGITLDGLPVAGVVNRLFYCTIDDVTCGSGAECGSLSYVWNDASTGPFLLHEGRRVLPRAAPVRDTIGPLTPLRVVRSGTTSGKCFDRFLLQLQPVEPRSARGAGNKLMLLVASGLHLSEAATNAACDVFVAPECSISKWDTCGPHAFLLAVGGDICTLRGEPIRCLFKGADTAKELLDGVVAVTRWSMAEVLRRMHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR1</accession>
    <name>F9WDR1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001899">
        <property type="protein sequence ID" value="CCD15415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16494" checksum="CCC739754EA3C552" modified="2011-10-19" version="1">MVVSALMGRDPMNTAFVVVEPQKPKLGRALEKRQVHAKHQKPKRLKQTSERSCRAVAPSSEAASCNIKRRVAGYLLQPFTRTRSFIGMRRSNTKAGQHLANTTDATLREVRKVMHTPLNFPAWCIDRPLCQPSGCRGKRINESGELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR2</accession>
    <name>F9WDR2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_06100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001899">
        <property type="protein sequence ID" value="CCD15416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06100"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390224" evidence="8">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="21"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD15416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="423" mass="48263" checksum="E87EEC6968CD64D4" modified="2011-10-19" version="1">MCDRYIFFLAVVVMLVGAVMVEARDLPALKLESAQGACAVSRLMKSMYNFVGSRNKEAQEMYESVERMYDLGRVRIAQHVLENGECDRMTFFVLFSQRIKENMTRKIRELASAGVKLVGAAGLAAGRLDEFINIFRHSWHVQTSHIFSTTYNHTYSFCLRGKGTKPVDKKSIVDCFMNDKETDDNGFVPVDGGDVHWLDQEDMGGLLDMRLKLVDGDPRDEHGQNRRCVLLSMEDSGNYLGGGNKGKKVLWADGLLGVTSGNKKKSGFTGSVRSSSYSTNIMWEAKPSSSIPVLKDFVVRYNDYRKLFDEVKHLSAAMTDDWTVDHLMKYAEGIASLLYKPEELDVLLSVDENEGNETAEEDQRRLRLRHTVEPFVGLNDRKQEWLAQYNKELVSKEFLAAEIQLCRSAAELHLRRNRWFFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE17</accession>
    <name>F9WE17_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2427</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001939">
        <property type="protein sequence ID" value="CCD15523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60290"/>
    <dbReference type="OrthoDB" id="1668132at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="48527" checksum="DB050CDBA6BA0929" modified="2011-10-19" version="1">MNMLEDKMTDNLAAEPEILQDGYNGAVPCDEPQLPPRPTTDDTREKSLSVLEQNDIPTDSPGKVLEDMQLADECNPAITTECEREDEPDNSLGVSDQLEEEEEEGSTVDDGDAVSDSAVNEDQPQARKVPVKPSQKDGVRRRQRRVREADYKAVTSSVINCAWGYTFSDTTGHVERSLLPPELLESREARRSHLNTPQALRLRVAQAARQYALAATGPESVEETSAAPRLTVSLLFQGPPPESGSSQASVKTHASPSCNRDRIPAEDEIRSDEENGEGSDRGVSMGDHGGHGTTLFHEPAADDDIKEGSVPHDDEPACMPSQGLPDGGEAVNDVVGCSSGPEACASDTPSVKPCDPSTMALLCRRNQKQAYDDFARPYRTSLGDAQVSPEATGAPEAPDASGERRDLEMLTPRVYPVASRVLEKESDVWEKVADILGELHDKMVSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEC6</accession>
    <name>F9WEC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 247</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_06520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001988">
        <property type="protein sequence ID" value="CCD15633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06520"/>
    <dbReference type="OMA" id="NGHTAQY"/>
    <dbReference type="OrthoDB" id="1377476at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="PTHR18952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="SSF51069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394711" evidence="3">
        <location>
            <begin position="18"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="4">
        <location>
            <begin position="40"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="414" mass="45237" checksum="260A081DB9604316" modified="2011-10-19" version="1">MIVALIISLLLTHSCEILYFADGTSSYTTAGMGRSEIPEPEWSYANLTAWPPLCHTGTQQSPVSFKGLNESQVQCTTQPQPLKFSEGCHFKAERTSLRIDNTLNTIRVLPLPLDDPRNKRPSACTIRDPTADAGSHPYHLAAMHFHTPAEHIFPRAAPDAELHIVFKAENEGSSVPVVVVAVQLVVSDAANTSATQALHHILLDGPLPPHQATTTCTLEKDMSIDGMLPYRHSYVTYSGSLTTPPCTEGVRFVIMTTPQLISKAAFRELSRTLLKSWQTGGLGNRRPTQPLNGRKVCRYVDERLPKMDGVAGGLMDDYFDARPPRGYTSTGNANASHGTNGTHVSEEGKQEGGKQTGPHALKPRDAIIFAIAAIMLLTAAIVLYWWSNNRNEKVDVSEVQWLRATDDGYGTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEL0</accession>
    <name>F9WEL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002031">
        <property type="protein sequence ID" value="CCD15721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07330"/>
    <dbReference type="OrthoDB" id="1724287at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17709" checksum="3221EAE01DE602D1" modified="2011-10-19" version="1">MSSGEERYLRLREAIAPKLKKDAAMEGAVDKLLRDAMGVLEGKVKGVSCSTLFDQEESALLEEINNDTRVVSSENVLQMPWEEESVSGVRYRCTVMSEDSCDSGWIRRDQPDNFNDILAKHLKKWKGQSVESEPKDFREGTRVVQGKRKRIDWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN8</accession>
    <name>F9WEN8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 295</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_07600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002043">
        <property type="protein sequence ID" value="CCD15749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07600"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37900" checksum="2904ED2D743EB9B7" modified="2011-10-19" version="1">MASDTSFATKTYVCVTCFILDVCAYWAVETRFLAPIFMASHYKYITGNEHAEPSSVLFWLNIFTFHNLILFAARALAERPELERLVRGWGLRLRFTLSIVLILAELALIFFLPVLSMSPPYAIVSLCFTTILGTIGKQFLGRTTHTLWDFLLTEKAGGVIRLTAFLVAIVHAMLCIIVVVPGTTGESRENTLSLHTVVYAVVLVIALVMVLSLALIRCTREGFRSAQRAAQKGRVEGINHLIERVGKTRKTLESIRVRLHAQSDPILRNEVQKEHQQAKRETVEAQEDIRRRLKDEASISALSRLAEFEAEWARPLPPEASSDGGNRDVAQSPQAPDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF77</accession>
    <name>F9WF77_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002113">
        <property type="protein sequence ID" value="CCD15945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09310"/>
    <dbReference type="OMA" id="FAVDHFC"/>
    <dbReference type="OrthoDB" id="677201at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="PTHR12124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="1">
        <location>
            <begin position="460"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="604" mass="66953" checksum="0C336E1B032CD26E" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF98</accession>
    <name>F9WF98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01090"/>
    <dbReference type="OrthoDB" id="1719490at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18951" checksum="0775E6259D4E3302" modified="2011-10-19" version="1">MDVTQMPCAAASATFFPTFLFVFYLFRTFLHMCMFCPLIPAHQSAVPVHFYFYLHCANFFRASPLTFLFICSISLLTCHSFWPAVLVPSWFGCAISGAISLAYKVMDGNLVFEACRRTAFRIDENVSVPRPGNLFVFCLRVTHCRYGGNKTKAERCNAVAFQYFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFJ8</accession>
    <name>F9WFJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 396</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002155">
        <property type="protein sequence ID" value="CCD16074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10370"/>
    <dbReference type="OrthoDB" id="580975at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="36918" checksum="B7E0D45A25661C2C" modified="2011-10-19" version="1" fragment="single">MLPLTDVDYALHGPVTAVSAGPSCLCFAVGNRVLGCNVNDFDVFVVAQLPHGAAITAVEQHTVVGSEGGVAGNLGIVVLVGSGDRVYAAPLHHVKVHEGEKHPVMRENAQQLLSLGTFARVLCIQTLGINAGVLVLTTLNSVVFIPEEGIVGTTSSSSRGTCTGESLVGVASYAAKGLGVALAASALVTTSQTDVLIFTGTYAGGVAVWGAPIKRLGSTAAGISSDGEGDNHNLPLLSWIAAHRPGCAIFAVKTFMVTECRDNSVQATRLFVATCSDDRTAKLYKSYVSNDMDTKECCEMMSSTKWVCCWCGEGATFSRRRLFDIAVLVTEADSSVLIATGGEDGAVHVFSFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFP9</accession>
    <name>F9WFP9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 414</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002175">
        <property type="protein sequence ID" value="CCD16126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10770"/>
    <dbReference type="OrthoDB" id="1722928at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16929" checksum="8C8A79BCAD1CA1DB" modified="2011-10-19" version="1">MDLEMFDRPGNVCHGHRVILADGLLDRGHCNRRVTQSDAWRAFVEQIAVIASIQPFQPAHALLGGQAVKDGNGRRHIGFQVAEHGVFRGFVTLVILHAERQGLRQGQPYQKDQRQPRDEGTRPMQRRLHAGVPSTCTGSEKTYPSLRTVLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT1</accession>
    <name>F9WFT1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11100"/>
    <dbReference type="OMA" id="AYINCEL"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="41747" checksum="C49D924BC57AF5CB" modified="2011-10-19" version="1">MQVTSAVRRRRDGEKTAAVFIDYARAFDSVDHNCIVKALMSFGVEMHLVAWIADFLQGRTAQVRVNNTLSEDIRLTGGVPPGSVMWPLLFIVTVDSLSKQLNRIPGLQHGFFADDLTIVCKSADRSAIQQTLQQGLDCITRWSEEHYVEVSAEKTEYTLFGARETNLLSLKVGETVLKEVRTPKLLRLTIQPHKGLSKHVQGVKAAADARLLQLRAVASPEWGPGQEKLRAFYRALVQAKVCYGIASWWFDTSLSDRERLEKVQAQASHIVAGVLKASNRNDALCETRVKPINEVAHRRALEYYPRLKAKESTHEKLAESIFPPEHPIHVGLSGDSLSQDFSDTGWFVFFYFCAAAKRRPHSVSSCAPWWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT4</accession>
    <name>F9WFT4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_11130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11130"/>
    <dbReference type="OrthoDB" id="1738125at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390284" evidence="2">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="18688" checksum="0B94162CE1818F4F" modified="2011-10-19" version="1">MLKLGVGIGMMVWVMVMVVVAEGTTGGTGTGSNGVCQLNENAAGLLCAIAKLVEKAKNITERHEEKDVKDALGDVALHKEQLGRHKELLEENLEEARQKGTLTAQQAQQLSPTAAEAQNKNKEVHDQAHEVMKNHTAHHDRTKNATKMALGETLIQANCGTTASFMTVLKCHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG27</accession>
    <name>F9WG27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 458</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002223">
        <property type="protein sequence ID" value="CCD16257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12050"/>
    <dbReference type="OMA" id="ISAMFIM"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
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        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
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            <end position="37"/>
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            <end position="75"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
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            <begin position="96"/>
            <end position="117"/>
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            <end position="146"/>
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            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20104" checksum="6AC7C0B52E2A4AB0" modified="2011-10-19" version="1">MDMKDRSVRKLVIATIIAMTMCFTLYALTALFGYLDFGSKATSSILLMYDPLNEPEVLIGYVGVLVMLFVSYALLGMACRNALYSLIGWDANTVAFWKHCIAVVSLSVVMLVCGLFIPKINTVLGFAGSISGGILGFIFPALFLMYSGGFTLQKVGPLCYIATYVLLLSGVIAAVFGTGATIYGVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002247">
        <property type="protein sequence ID" value="CCD16324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12630"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="VSG_B"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="229"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD16324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="36918" checksum="EC3D57A62D4B50BF" modified="2011-10-19" version="1">MGNSSDVQAKSTITREADVAQAIISRITREVHTILGEIKKVNTTRNIEKVKSEFAQIIFGDEGNEGDLDHGALKEVTDRGAACGNPGAAKKGEHAGNNLVVDFFCLCAMTIGAEGIENVCGVYVGGKGGKSKPDKHGWDEKNSPLGSSAMWASIKKGCRNLMHQHPKSTEEGKEILGDYVKHLKSGGVYRWDSGKQSERKRGMLGTGVVTNDGSEKGPACNGKKGSGRGQPPAGICVYYGLDNWDHNIDWLNRFKTALAMVDALNNKTANIQRDIEKLHMLLHRAEEIYETTNVISKVQNPVIPTSLQTAAKRLTAYNAAWRHPRYAHFLAPWVILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGA7</accession>
    <name>F9WGA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12800"/>
    <dbReference type="OMA" id="NALEITH"/>
    <dbReference type="OrthoDB" id="1758136at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
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        <location>
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            <end position="181"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="543" mass="53544" checksum="F4F8FD4DD940148A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGC7</accession>
    <name>F9WGC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 489</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002258">
        <property type="protein sequence ID" value="CCD16361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12990"/>
    <dbReference type="OMA" id="WYKDRCR"/>
    <dbReference type="OrthoDB" id="1205219at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="612"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1177" mass="132358" checksum="8FCA52DC788B31BC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN0</accession>
    <name>F9WGN0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002292">
        <property type="protein sequence ID" value="CCD16467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13870"/>
    <dbReference type="OrthoDB" id="1729683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21133" checksum="0D5AB9D8A4AA25F5" modified="2011-10-19" version="1">MRRVAAGCKFLVDESRPLLLEYFGGVWCPAIDLPWTVVPRLPSLPLLLLYYTEPLGGLLPIENLSSHPAAGPRPTVFRPQLVEAPLKLPSSRSYGLEESVPPHPATCSRKLAALSSKYPGSWNLAADLQWTVVPRLIFRYSDSESKPPLGGRQQTAIFFGFVWSLASISLLGILLELNFFLLFTLRTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY8</accession>
    <name>F9WGY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002353">
        <property type="protein sequence ID" value="CCD16577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01700"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="584" mass="64910" checksum="24AA73052850F266" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH13</accession>
    <name>F9WH13_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_15120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002359">
        <property type="protein sequence ID" value="CCD16602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15120"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390324" evidence="5">
        <location>
            <begin position="24"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="51"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36038" checksum="72AF408823B99B63" modified="2011-10-19" version="1">MEREMWRMVLLVLFVVGNGLCASKNNEEVFEKLCNIAGNVSVLMEKDSGATSPLEEALYGTVGRARFNDDGTFAVNNCGLGHQMRSHFCSYKLGAGSSGHGFFADSLLGTFLCLCTEGHQNEQNLCGLGNVGDNARWTGWNHPPENLLKSVWKKIKEQCITQKRNKLSNSADWEKLESVVNNVSVSLKDVKEGYGTLGGTDTNGICSGTSQGDACVTYKANGGNEPNIPWANKIKDAIQKLNQTQSQTRSQKSAQTSHHRDSEDSSEDSAESNDDGEEEEEVEETAETIGTNNASKTSSPKKKRTKKPSNKATKKQERLSIHSLLKTAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH19</accession>
    <name>F9WH19_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 583</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002362">
        <property type="protein sequence ID" value="CCD16608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15180"/>
    <dbReference type="OMA" id="DICCVRL"/>
    <dbReference type="OrthoDB" id="1550415at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="327" mass="36198" checksum="03BBA57CBD9B0B81" modified="2011-10-19" version="1">MGGLSFAPCVEDDLLNPRHRDAGANALAEARRLAFLYGRAEEAYDSLRQHAASVGSSSQLQRDWREASIALLSLHGESGASAQRWMESGLLPFPAGEKDFAAVAGMPPWLYHHCMMYWTKLGCAALSQEGALGLTPKGASETLQFVVRDICCVRLAGAPRSIPHWTLLERVLSELLRHSQVPIADACPGLSAAQAMVELMVHYLRLYVVRYLQLRDRPLEGRRGLLHYRGVFDRASEGVNSSCVREAVACRLPTELPEMVLSPKHLLMAVQVLCGCDEAGMHWEKDLSAMVGDDSDVAGNRKLEELLNLYFFSSPPMAFDRLPHQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI3</accession>
    <name>F9WHI3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 652</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_16770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002439">
        <property type="protein sequence ID" value="CCD16776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16770"/>
    <dbReference type="OMA" id="AYAAQVK"/>
    <dbReference type="OrthoDB" id="571919at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035256">
        <property type="entry name" value="PSMC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073:SF120">
        <property type="entry name" value="PTHR23073:SF120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="140"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40522" checksum="B97D43D64BBAE186" modified="2011-10-19" version="1">MICKTETHHLQREESAAKQEVKRIQAVPLLLGTFVEAVDAGRGIVGGSSSSNYYVRILSTLDKEKLKPGTSVGLHKGSNSCVQILPNEVDTDIHVLRKEDRPDVTYSDVGGLDMQKQEIREAVELPLTHASLYDQIGIDPPRGVLLYGPPGTGKTMLVKAVAHHTNAAFISVVGSEFVQKYLGEGPRKVRDVFRLARENAPAIIFIDEVDSIATKRFDAQTGADREVQRVLIELLTQMDGFDQTTNVKVIMATNRWDTLDPAILRPGRLDRKIEFPYPDRRQKRLVFQVCTARMNLSPEVDLEEFVTRPERLTGADIQSICHEAGMLAVRKNRYVVLPKDIESAYRTVTRKTGEEQYDFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIL9</accession>
    <name>F9WIL9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002617">
        <property type="protein sequence ID" value="CCD17167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20120"/>
    <dbReference type="OrthoDB" id="1727898at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15677" checksum="9CF4850EAB3B9E1A" modified="2011-10-19" version="1">MIYFSFCSNQSGKFKPFQYKTEPLMVSALFPFIAPAAICRCAFTLGCTFRYNVVGSFFPLTSNVLTGACFIHTASPSKQTDKYPSSSNKCRPYGSHISVPFTRAHPFRYAPHSQLPVKLLLPMDGSVMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT2</accession>
    <name>F9WIT2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002635">
        <property type="protein sequence ID" value="CCD17230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="15201" checksum="8CDADE705C953E4B" modified="2011-10-19" version="1">MLPPVPYPVETRRCVHGSRICEKEEQKKESEREKTIEEFKEGKQQIKWAPGVSLYLFSSSFPTSVCSSLFILSPRATDQQSEEKLTPIQTSSQTNKDYYYYYYSLTIKKKSSGVIWKRRKRKKKTMMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ3</accession>
    <name>F9WIZ3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_02360</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002665">
        <property type="protein sequence ID" value="CCD17294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02360"/>
    <dbReference type="OMA" id="MGEMLME"/>
    <dbReference type="OrthoDB" id="731098at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="PTHR21443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10191">
        <property type="entry name" value="COG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="154"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD17294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="780" mass="86783" checksum="80C1BF44B76132FD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG4</accession>
    <name>F9WJG4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 907</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_22870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002722">
        <property type="protein sequence ID" value="CCD17469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22870"/>
    <dbReference type="OMA" id="KSDVYCN"/>
    <dbReference type="OrthoDB" id="1484694at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="2">
        <location>
            <begin position="129"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="588" mass="64853" checksum="7B37AA0517E3396A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJG5</accession>
    <name>F9WJG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 907</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002722">
        <property type="protein sequence ID" value="CCD17470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22880"/>
    <dbReference type="OrthoDB" id="79800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="PTHR21610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16567" checksum="DA79E353001D4835" modified="2011-10-19" version="1" fragment="single">MLRGQALLISVTCVRLRERVGGPASRTPARAYPSMSGRHLVSCNDLSLTIGDVTVPVPAEVSHPERVAWLLPGEANNLMTSLDDKNDDGELSLSVVTALFHLDDGITRKYLRWICQKELLRQDMCLVGEPGPALRWLVLLYSCITRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJJ0</accession>
    <name>F9WJJ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 916</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD17495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="EHYLGRE"/>
    <dbReference type="OrthoDB" id="1667222at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="17812" checksum="F5225E50FB01BBE9" modified="2011-10-19" version="1">MLTLDHILETVHSAKELTTAYLSTVDKMKDGVEKGKPMKEILEDARNAGKEGAVVLVAKPHPSTGENATAASETGGSDKVEEEVKVNVKLDGLQFDEDESSLANSKDKFPKYYVYLLAVLVPVCSIALAVAIFCIIRRTRPAHAEKGIPVEGAAAGKLQDGGKTASF</sequence>
</entry>
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 932</fullName>
        </submittedName>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002749">
        <property type="protein sequence ID" value="CCD17542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23560"/>
    <dbReference type="OrthoDB" id="165279at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010252">
        <property type="entry name" value="HutF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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        <property type="entry name" value="PTHR43608"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="hutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="48"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="33869" checksum="0964D96BFDFA5B5A" modified="2011-10-19" version="1" fragment="single">MSAFFAERALLPNGWANDVRLEVGADGLLTKVEPNASAEGAERLRGPVLAGMPNLHSHAFQRAMAGLAEVAGNPNDSFWTWRDLMYRMVGKINPEQLQVIARQLYIEMLKAGYTSVAEFHYVHHDVSGQPYADRTELSRQISQAAASSGIGLTLLPVLYTHAGFGGQAPNEGQRRFINSTEHYLDLQARLQPILAAQPAQQLGLCFHSLRAVTPEQIHTVLGASDKNCPVHIHIAEQQKEVDDCLAWSGKRPLQWLYDNVEVDDRWCLVHATHADADEVTRMANSRAIAGLCLTTEANLGDGIFPAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJT8</accession>
    <name>F9WJT8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_24030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002769">
        <property type="protein sequence ID" value="CCD17596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24030"/>
    <dbReference type="OMA" id="HPSDEHY"/>
    <dbReference type="OrthoDB" id="445975at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="SSF51045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="450"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="692"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="859" mass="96754" checksum="FF0F89C5E0971042" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJW5</accession>
    <name>F9WJW5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 960</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002781">
        <property type="protein sequence ID" value="CCD17623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1656044at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="611"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="755"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="888" mass="103130" checksum="C8B37A2A6DF79D92" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK59</accession>
    <name>F9WK59_TRYCI</name>
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 989</fullName>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
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                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
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                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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        <source>
            <strain evidence="2 3">IL3000</strain>
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    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <begin position="501"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17720.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="601" mass="65120" checksum="0D568386862F51A3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK85</accession>
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            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="CAEQ01002823">
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    <dbReference type="Proteomes" id="UP000000702">
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="218"/>
            <end position="246"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
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                <person name="Quail M.A."/>
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                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <feature type="non-terminal residue" evidence="2">
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            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="322" mass="35085" checksum="69F55EF4BBF33583" modified="2011-10-19" version="1" fragment="single">MCILKNDFVVQLLKQIEVDDVVSSLNHIAVRLPHGNPVGIIPGQLIIVKEKHRSTTIGSCSGEITTLLSPEESSYQSAVRGGDASVGEPLLLWVPHSSINSEFSHLVSRLCSPSPPVKDLHEREGCSGPRKWEHATAVRISCIDKIRRSINSNGVRCIEVYLLDTQSTISFVFQHGGLTKFFEEMRNLTPMVQSSFSIDDFIVYGEPERERSMEDHASEGEELAEGGVPGNFRSSHLRALPGTSSTVENASVSTFHAGGRMYGNNHCYRDVQKALYHSSGESGIIVKGATKVGSVLSSFLGFPTKSQEEVSSNALSSSLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W374</accession>
    <name>F9W374_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1012</fullName>
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    <gene>
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    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1068625"/>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000365">
        <property type="protein sequence ID" value="CCD11582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25530"/>
    <dbReference type="OrthoDB" id="51773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="47022" checksum="9890FB9FD2934F95" modified="2011-10-19" version="1">MSSLSRSLASKGKAETIVESLRDDLRRVAMKCYTRSKKSLMHAEGTAIPKNDRSRNGSYNSNYAASSGITSLPLLYAPDVVEEVKDIELAGEEARDLFIRDPARYDCVIDDIIRRATQRVNDEDFLSSHPSAKRSLTMKFTDSMVGKRDSGAQSRRYRSVSTSRNKNWTGRVSEDSLEKESVQSHSMQWSASRVSSANTAPSSNVLMLRVTDNFQRLLDEQCRAKRIIAYILMEMRRMWRLRRLEGDIALRAAVDRYVFRSLAFTWRIERRRVLNLHKLINLLDRQTGRVKGWIPFYSKDNVLIDRYVWEPVPPELSHRMNVVRHAMCLARRHQLVPLHSVRNFSQMEPSSHHLMFGYTRRLVGPMMKVPLQRRRERRARRAAPFQRPLKTFSPQKERDIGTPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W383</accession>
    <name>F9W383_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000369">
        <property type="protein sequence ID" value="CCD11591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="12895" checksum="AE05F437151176EE" modified="2011-10-19" version="1">MGECLHSHRCGDAEYRLRVIFSVFFCSFRVRSLACPAVLMEHTHYPHPPFPRLPRAPCALSAASVFSARGISAPLLLHGYATQISFAASTLHSRSSHFLLKKNSWCPSCLFRFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D5</accession>
    <name>F9W3D5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1040</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000396">
        <property type="protein sequence ID" value="CCD11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26110"/>
    <dbReference type="OMA" id="HTSSVPH"/>
    <dbReference type="OrthoDB" id="1704886at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="21978" checksum="414B3C9F980E29CB" modified="2011-10-19" version="1">MGDIRQIGDTEHISDIVQIGDTEQMGDTAQMGDTVHIGDTAQIGDTVQMSDTVHISDIAHIGDTVQMSDTVHISDIAHIGDTVQISDRRQMSDTVHISDIAHIGDTVQMSDTVHISDIAHIGDIVQMSDTVHMSDIAHIGDTVQISDIAQLSDTVHISDIAHIGDIVQMSDTVHISDIAHIGDIVQMSDRRQVRQCISVILPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U7</accession>
    <name>F9W3U7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000477">
        <property type="protein sequence ID" value="CCD11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27660"/>
    <dbReference type="OrthoDB" id="1700037at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="195" mass="22348" checksum="65BEE15EFFC354CB" modified="2011-10-19" version="1">MKTHNYHHKKQSHDMKISLREFTLTRRGSLLSVNVMNTVLNGEFVVRQTLFIIPVGWHSFFGKRGLLVFITGINITTTFLPAITLGATFPHCAVMIETPARNVFSQSRHLPQSPNITMKSSGNSWCVWRTRMESDRHCLKSVRAFGTQCPSTYACYLPVDCMSCLTMIHKNRKVCGRGNFLCLHKLYSWSWFSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Z5</accession>
    <name>F9W3Z5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000496">
        <property type="protein sequence ID" value="CCD11876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28150"/>
    <dbReference type="OrthoDB" id="1728330at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16623" checksum="0FFD46CFF4F7C439" modified="2011-10-19" version="1">MSRLDEHVQTIHDAKLLTTSYLSIIYQMQEDVKHGKPMKAIVTNARKAGQKGAQVVVGKTGDTSPKASHPTAGEKEEVQVTVQLEGLKYLEEEDPDPAHSNESFPKVYVYLLGLLLPLCCLIVCLTLYGVLRKPRSRSSPSHLDDKGSIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W401</accession>
    <name>F9W401_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000498">
        <property type="protein sequence ID" value="CCD11884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28220"/>
    <dbReference type="OrthoDB" id="1672559at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="40266" checksum="CE652080ED8423A7" modified="2011-10-19" version="1">MGLLCISSSSVFFKKKKKMIKSFKVILMVTVMAIGVQSNEEEVILNSSDFGLLCNVTKVVMGLWNVADAHDHLFDKISNLTRKMDEIYFGSKTGEVSGRFPILPADFDGQQPKRSEVCRSSSVPNGVPSASDSLASTIFCLCMGTTGDGGELCELTIDGSGVWPENEEETVVVDFHTVWDDSDKKGVIGKCDSSDLGDNLTKAKEDLAEKLGALQTALDKKIGSFNSNKPTCEKLSACAKVPTNPTWLKKLKEFKDLAESLELPLKTAQVAKAEVPEAVLANGDVITHESHTENAATSAQAASAAPFHTSSQNYAETSKQEPKKASEEKAVLEPENPEKASTRSAADPPSTTENETSGSIINIPKWTSLVTLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A6</accession>
    <name>F9W4A6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000534">
        <property type="protein sequence ID" value="CCD11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29200"/>
    <dbReference type="OMA" id="QRAVNAC"/>
    <dbReference type="OrthoDB" id="1497017at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16691" checksum="A6DEBF753659985D" modified="2011-10-19" version="1">MSQWVPKTAWKVSNLNKRYGPGYVTSGFTTKGKYGVTGMLFNTHKLRERLSSTRDIVIIDVRDAAERRFCPVSCSVALHYHDLLSGAACPILPQQKEASELFILSNDERRGFNSAAALRRWGYNNVTSVDYKTLIEAGCVPAGNLYKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4D3</accession>
    <name>F9W4D3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1172</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000544">
        <property type="protein sequence ID" value="CCD12023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29440"/>
    <dbReference type="OrthoDB" id="1727224at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19445" checksum="BC7C66A3D65C0F4E" modified="2011-10-19" version="1">MSPGEGTCISISIYIYIYMHVLLCKYNGNNIFLLFFSPFFSQYNFCASFSHFHFFLCFCSCRYRGTLVSATHGSVRGPGVLHAVDERVLTPSKRCPPARVELPKGVFFLCVGRDVVSFSFVPYCIARGIVRHPVRGYKRGALWTKRCGSLACDRYCWCSRGYRSASSLRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U9</accession>
    <name>F9W4U9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_31020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000610">
        <property type="protein sequence ID" value="CCD12196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31020"/>
    <dbReference type="OMA" id="ISTLMWV"/>
    <dbReference type="OrthoDB" id="1351297at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PTHR12841"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="26388" checksum="6329AB362049CFEA" modified="2011-10-19" version="1" fragment="single">MTQGGLSLLSRWVSKLPEFVRRAFQYDQMELDSALAQMYLLCVKPSLISKMSKARKMTKNHYYRDDPAFIVLQAFSLVITTVAYGLALGSGFLQILYNVIYTVFFDYFITGALVTTALWLFANHCMMGTNRVQDVGREVDWRYSFDVHCNGYFPYFMWTKVFHYILLPLIFHGPLLGRLIGNCLHTIGFVAYSYITFVGYLELPMLVQQQRLMYPVPVVILFMLLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B3</accession>
    <name>F9W5B3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000689">
        <property type="protein sequence ID" value="CCD12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32470"/>
    <dbReference type="OrthoDB" id="1706543at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="27202" checksum="52EAE2C47AED8A0B" modified="2011-10-19" version="1">MYKRLVWSPDRDEHDSWLPKRARPKSRKEEVVLLPGDDEWMVVIRRRQPPRNPSWTMRSAIREVLLEGMKDPNHLNLFDFLQLYYRDVPENVARFTVGDFLRDPRRCMKDKDRRKDIGMSMSQMRSRLREKLLYVSYDLFSCHIQTLGDWAKKGRSERVEAIVRNLLDEAVKQAQEHDQAEKHDPAPLPEPLSSLSSCSRQESGSSSDVEVLSVVLPPEKQEDSPTSGTQPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J1</accession>
    <name>F9W5J1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000718">
        <property type="protein sequence ID" value="CCD12443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33220"/>
    <dbReference type="OrthoDB" id="1749557at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="18989" checksum="810840D90D1B22AB" modified="2011-10-19" version="1">MRARTSALLSSVLSSFSALFPHVPASFAKDAPLLTGGLLQWVPYVACFVAPFLDLPHLTHPIPAAHTLQLPLQHGKPHVPATLSSPPLLSAAASSAASSAAMHGGSSGSVAPPCLPIRCRSLLAHALSSRLHTRHANSPLAFGPRPLEDRGCPSPPLPPQLTFLSALGVSLATAISTTGTPQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5T3</accession>
    <name>F9W5T3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1373</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000766">
        <property type="protein sequence ID" value="CCD12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34080"/>
    <dbReference type="OrthoDB" id="1727184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16313" checksum="E86D1F3D27232E54" modified="2011-10-19" version="1">MPSGGRESGVCIVVLLRTCEGLHVVCVLRCGVCGTRAVCVCLLWGGVPLHFAPLETQPLSRFPSFPLRVITAASFHLCSSRTPPLPPPVFTSKLFELKRQGGDVVVGRKAFFPPQQPSPPPHCGTGVCVSAHLQEFICIHVDRPECGRTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5V4</accession>
    <name>F9W5V4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000778">
        <property type="protein sequence ID" value="CCD12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13231" checksum="B311F557B92007F9" modified="2011-10-19" version="1">MKREGGSLSMRGTLPAPELNALFFLLLFITFPHRSFVSPHERGRERGEGVGGSNEKWANAPLCNITSTTEICSVTRGASMDSEKEETPLQPLPPPPPPANNQKSTLSKSLIHHFYTRSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D0</accession>
    <name>F9W6D0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000849">
        <property type="protein sequence ID" value="CCD12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16179" checksum="F3897E7719BF7B40" modified="2011-10-19" version="1">MARGEQTVCEAHCVSFIPAVLFIQILVTFILSCICHACGGHGTARSHHLGPILLVAACVNSHLQYRYFHSLFCSHFNALGLCGISIPIVVIDIMCVCVYACVRVGATVSWHSGWCCHFIRIGISSFNAPIAFLSFLARALLRCVAEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6F0</accession>
    <name>F9W6F0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA_ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000855">
        <property type="protein sequence ID" value="CCD12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="631871at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA_ligase" evidence="1">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16597" checksum="443ABFE49AFBF39E" modified="2011-10-19" version="1">MRPQRLSVPVVTRFSHVCAHWRTASVALYPAVCGSSSIFTSTRAYMPLPNDQSDFSPYIEIDLPSESRIQQLHKSGLGGQEWVACEKVHGTNFGIYLINNGDHETVRFAKRSGIMDPNENFFGYHILIDEFTAQIRILNDCSSKNMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6G2</accession>
    <name>F9W6G2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000863">
        <property type="protein sequence ID" value="CCD12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16176" checksum="BCBA60E90C87C252" modified="2011-10-19" version="1">MCVCVVQIQREFPILAHGTRHTCCSFYIYLAPWCVFLFSFAVQGGLSGERVVADGTTNLVNRFTRCLVGVACCVFYFFCSSPYAAVINISAHNALMLRIHICASLWVLLTYILYFYSNRLLFMVSFFLLLVLSSFFLLLLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6G4</accession>
    <name>F9W6G4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1461</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000864">
        <property type="protein sequence ID" value="CCD12769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36220"/>
    <dbReference type="OrthoDB" id="1673597at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="345" mass="36097" checksum="CF1CFF0E56D7019E" modified="2011-10-19" version="1">MTSSGHVTSRSCSGSGVPTTVAACCRPTATAGAQQSVDYKAFGMCSSFSRSAAREELVSTSRSCSPVVASRHGGDATAVPHAAVCAEGSVAPAPCGSSPTVLASAAPSLGGDERPSESEVGVVRATKNVTHVGSATVRHVDACVQSDAMSEVPGLTSKYYSCRKPLVLPEGHQNVGIGISPKELRLGFDESRKCTPLRHSDRSRHTQGAVAVAPRMGPVRCPACSQSNFVQPVHQRGIRHNNATNTLSSSPLFVATGGASAGNSSGQAGRSAIFRHPLIKRRCVSIAGPVLPRPPQLQEGRGGCRRFPEEGTMLWMCSRRRVPSLKLGSEMLWSGWMSTSLSCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6M9</accession>
    <name>F9W6M9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_36770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36770"/>
    <dbReference type="OrthoDB" id="1671235at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388734" evidence="5">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="50"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="345" mass="38072" checksum="3B7AA561454A1CD2" modified="2011-10-19" version="1">MMKFLIVVMVVIGVVGADQVGGAATLTNHNEASHRALCDFLKVAVDKWKEVKTRGPTDPLRKALKDTIFGYGSGDEDMEALKSKLPRDYEEVWSGDLSSRTIWCGEQHEGYNGVNQARWSGHSAPHDMVCLCTVGNKGWPLNKSDATNPEKEQLCGKGPIALKAGDDKGWMGSKSGKEQIEATWMNVTVPCLNSNGQGNKLKEAFQKFKNTLGPLVTGDPTHQMLGEGNFSVYHGCDGSPKLGVCVVYFPNDKDTKPWWKDLEQAIKEDEEIKKRLADEEVARQKEQEKERLPRAEAVTSSPPDTQDGAQNKTDTLHDKLRKFNLTSGTPISRPSSWLLSAAMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T4</accession>
    <name>F9W6T4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000934">
        <property type="protein sequence ID" value="CCD12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676595at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="12869" checksum="561EDC63373BFBE0" modified="2011-10-19" version="1">MNSQMREAARYKIDTTRSRGELLVGEGVREEAYKQVRALVEDMEPPQLPGVLDVEDHAVAPSRAVGCREQHFQRFLQETTGMDALEEVAAPLSVGEAQEKAINSFGRRDDNGRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6X5</accession>
    <name>F9W6X5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1532</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_37530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000944">
        <property type="protein sequence ID" value="CCD12932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37530"/>
    <dbReference type="OrthoDB" id="1345899at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="DNA_recomb/repair_Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RECA_2" evidence="2">
        <location>
            <begin position="111"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="520" mass="55644" checksum="48AEF9BDAFD9E99C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Y3</accession>
    <name>F9W6Y3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000945">
        <property type="protein sequence ID" value="CCD12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37610"/>
    <dbReference type="OMA" id="NREMSID"/>
    <dbReference type="OrthoDB" id="1614374at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="39371" checksum="6993B76A44151D3F" modified="2011-10-19" version="1">MSIHPVREYDSEDSLDGLTLTTTRLSWSTKCIAGSKEVNTSGVSGMSDTLMGAGGLTTTHSSTLHDSTITMSSPTTDSVHSQPRGFGSQEGYRKRARCGSAISPEQIWEDEGEVAHVRDVQRTEIRQGFSTWTPSTVRAAAPQSGGASEPLSPYEVRRRLSLHTLGRLSGVLPPTVMATPISGQVPGVNATPSFASVAAVPASGRPSTIVTPTPTPLRRYGDPSSQMMLMARTDDPPTESRPLLTQPGCSIPSPRTPLWTAPEEEMGADAMLNGNHEDNDDHRHDDLCEDDDDDVIVRLPLARRLSNFSRVAPLSQLSVSLSTAPGTQRDADEAVQPSSADKWVGQMRQFFARIDERPLLVLVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z0</accession>
    <name>F9W6Z0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000951">
        <property type="protein sequence ID" value="CCD12947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37680"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20206" checksum="6FD830D2E69D8113" modified="2011-10-19" version="1">MSGSPSSPSPEGMEREDTQWSMEKDMVEVLLKGLGSPEKINLYRFLEPAYPWMHSYVSRFSIRDFARNPWRCVGEADGREKVWQQFPRLLWQFRVLALKLVCYAGLPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W705</accession>
    <name>F9W705_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_37820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000959">
        <property type="protein sequence ID" value="CCD12963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37820"/>
    <dbReference type="OMA" id="WNNRIAM"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="622"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="846"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="970" mass="106631" checksum="9A0F1A30208CFBE9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W745</accession>
    <name>F9W745_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_38220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000980">
        <property type="protein sequence ID" value="CCD13004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38220"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394729" evidence="5">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="363" mass="40098" checksum="B08742AB4B135FDD" modified="2011-10-19" version="1">MRSMMLFLVMVAGMFSEVNTNKGENDYNKDFKDILCDVYMAAKGILSNAGITDEAMQKDVKDAVYGNNKKNAQIKYSGHVEKASLCGNSFHGRGFLCKYKRGGGCLSQSVLGTFLCVCTPGLGSANDKLCGVNLSEYGGQTWSGGWRDNDVLDKTQLFKKVLDNIKYNCTQENGNSQNQLDELGKLEKAVQKIREKVQRGTFGDIYFYLGGIGGGCDGKGVNDVCAAYEGNEKTTVSVKIPWLEKIQEALKTVKPHFKNRRAQTMSKTFPSGNASLQPGTGAARDAENQKELVELPTPTQDEPLVNKKNESETPTPEKKALARTENNKTFRYTNSIPYLAKDINEDNAKITMPKWILQGFILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W765</accession>
    <name>F9W765_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38460"/>
    <dbReference type="OrthoDB" id="1709086at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="25971" checksum="6B485236E30AFE1A" modified="2011-10-19" version="1">MLDLTTKSAMYILLGMIFFVSAILAIVICIEKRRIAAAMQRRRRLQEEADRNATGEQLLRRLMRQAIQMLLTHKLVDEGIPLASSFGVLEVMADRELRSNRNRGRPPRLTMADGTRDTITGVVRRARAAGPLPDSPPGPALMELLEALRERQQREAATQPFSESDRTPLEELIDGLVKAEEEVRSAEIEKEMETFSDPNQAYGVAAPYTPNPANKCIRYVMSSGKNNASAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q5</accession>
    <name>F9W7Q5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1641</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001065">
        <property type="protein sequence ID" value="CCD13227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39970"/>
    <dbReference type="OrthoDB" id="1707859at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="19416" checksum="A66AAC1CE1692C75" modified="2011-10-19" version="1">MVFAKAQGGTDLMGKVNYCLGVGGRPARRRDLLDCFPEGKKLEIGEANLAKIPESTMHNNEPYLTAIMEDVKHSSLASYFNRKYGGDGDSDCNLINGSGGILSSALHDNLWWGGGILTIGKGFTGFLSGKENFIAGEIKDAKEANKAFWTALPTSLAPEQNANRIPSFQGRSSNNYSKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W7</accession>
    <name>F9W7W7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001092">
        <property type="protein sequence ID" value="CCD13289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40570"/>
    <dbReference type="OrthoDB" id="1700203at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23399" checksum="6CC03AEC7ACEAFD8" modified="2011-10-19" version="1">MKCELSQTPGIQGRQNVEAAWGSRENNSSTRGKRRANAQVEAGGMVIAKAARKCTPEGDTSCEQSTPQQRRISLEPKQSQQDDNRGYKVLCDVCGRLVGRVDLLLHIGVHRTNDKLVTRSLLLEYGMNKRTAQEGNSGKEYEVWRGHARQNSAMSEFKHARCGRWYMTRSTLEIQTRVHHPKQDTVNREMPEGGMKIWKITKEKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8I9</accession>
    <name>F9W8I9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_42670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42670"/>
    <dbReference type="OMA" id="AMDPTNK"/>
    <dbReference type="OrthoDB" id="264244at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="PTHR11566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394776" evidence="3">
        <location>
            <begin position="25"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="49"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="601"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="693" mass="76567" checksum="191059C2C70268AF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8K8</accession>
    <name>F9W8K8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_04510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001177">
        <property type="protein sequence ID" value="CCD13542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04510"/>
    <dbReference type="OMA" id="PRENCRS"/>
    <dbReference type="OrthoDB" id="744341at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="88"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="353" mass="38709" checksum="EA1B1FC02C34EEA5" modified="2011-10-19" version="1">MPAKKKGGRGKTLNIVDFNEDYVPEDNLDWAVVVPQEKTQEQVLQEKLAKREYSRTANNVLVESGGFREAPSEDTNRRVGIEDLQPPFVAHFGNLRNGTTEEEFLRNFHEDVVVTSRLINQEGKSFAFVEFKTAQALLIALAMDQSVVKGRKLYVDLATAKQVGRLRGHGSGLSRQNAGQPQQGNAMQNLDISRDAFGSTQPTEREKDMGSRSGFGSRSDLHILADLSRDTLGTATRPPDSALSPIGPPDFASWRTEAPAAQPEFQAPLRENRRSDTDLDRRRGRNSKGQSQGLGSLASWRDEPMAQAPPMMSTAATEGGALNNGSAPSRGGRAPPRSTAAPPDTCKWEELRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8V5</accession>
    <name>F9W8V5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_43790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001223">
        <property type="protein sequence ID" value="CCD13641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="GQHGKAF"/>
    <dbReference type="OrthoDB" id="1431042at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PTHR13848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="14177" checksum="BAF4E4460F4A1716" modified="2011-10-19" version="1">MVQRFRVLMGGSEGYSCRRCGAHLCDVGDVISREFRGKHGKAYLVNRCFNFYFGPPEEKELRTGKHIVRDTFCSNCDAYFGWTYDFAYEDKQRYKISRFVMERKLLQLVSVPPPSPTGGEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W938</accession>
    <name>F9W938_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001257">
        <property type="protein sequence ID" value="CCD13728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1343847at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388852" evidence="1">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16968" checksum="E84D10A2B71F24B9" modified="2011-10-19" version="1">MVPWRWVPAGSAVCIFCAVVHGPGNVLGALASEHQPEQDAKSNTVSEKSALMKFLLLNRDAEPMPYNVEDVRWVDRFAHPAFIVTQQARSRGEEEPLVVPAWMRREYFGENVGTIMRFLGVDEETIQAWQKWWYAQLDHYNMFSSIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W970</accession>
    <name>F9W970_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1829</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001274">
        <property type="protein sequence ID" value="CCD13760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44670"/>
    <dbReference type="OMA" id="NWENTAW"/>
    <dbReference type="OrthoDB" id="691939at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="108"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30664" checksum="B4E2437E55AAE47C" modified="2011-10-19" version="1">MTPRANTEGCDTLLGDDREVVRRKSCPAYFLLSFFLVILLAMFYHAASPLWKEKGDDYLRTGAGIVDVPPGCRRGCATPFGSVLGEYNGVKGMSNCDSDTCIADHWHTIDVSELRDAIRMETFPSSYGVKWQCVEYARRYWVLRGTPKPAAFGSVEGAADIWDLDNVALLDGTTRPLLKFQNENATAAGSRPRAGDLLIYPRQPNGFPYGHVAVVAGVEERRLFVAEQNWDNQQWPGPYHNYSRELKLTCDASSTRCSVHEEGNIVVQGWVRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W984</accession>
    <name>F9W984_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_44760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001278">
        <property type="protein sequence ID" value="CCD13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44760"/>
    <dbReference type="OrthoDB" id="1664965at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390027" evidence="5">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="110"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="46166" checksum="640916D629024FFC" modified="2011-10-19" version="1">MFFVLQLVITVLVAMPSRGTASRMYNVAEYRALCSIYRVVLKHCGDTEENYVSSKFDWSGVAGMLNDVTKLTAGTSGTNESSDEVQTESGVRGLVKSVYAIRLNATTAFTASRLQRLKDRIVQLKKEAKAKAREAIGELKKAIGSESDLCSSPNTHVKVPISGKRSHVCNSVSKGGTAGVSLMTDLLCLCASGEKNNQTCGFEAGGGLKNWTDTSTDVTDEMWKKIRGNCLTQNVSDELSAQNLNVLIDRFHKLLGAQVVKWVHENEQCRWFLGHAGSSRPNCSGKERDDICVNYARRDNTLDTIAWLGHITTARDALVALELKVSLAEQLERQAMQIKDMFEHEISVLNISDDSRGAQWALGPLRTSSERRGEDGDTADVPSAEAFESSAEGRSVRGAALILFAEIFYQLFVLRYTTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W993</accession>
    <name>F9W993_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1838</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001284">
        <property type="protein sequence ID" value="CCD13784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44850"/>
    <dbReference type="OrthoDB" id="1720583at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18782" checksum="D13011B5E0F304C8" modified="2011-10-19" version="1">MEGTQIIAHQLHRKLFHSTGKNCFLYTPLTLITPNPLLPTAHYFLSSSRYTVLSRNPCLHPAYLFHPTHAHKHGTDDNVSYSPLFFCFLFSVPLPSTRRAGEITKEAHDAIDRGCSNVKDFRKQWWQDKHVSWGGLALLHYASTFEEHSPPLALTHRREGVPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9C6</accession>
    <name>F9W9C6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1849</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001296">
        <property type="protein sequence ID" value="CCD13826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45220"/>
    <dbReference type="OMA" id="RKEEWCI"/>
    <dbReference type="OrthoDB" id="973865at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="442" mass="49809" checksum="A628B54922B462E1" modified="2011-10-19" version="1">MLFWPRDALLLYIHAALCICLPLIVFPSLSLSPSLAHFSFDLQGGMAQNSSEEKDAWLVGLHQFLNTRLRTVPYAAATRVRPNVSVPLPLQNTQYMINGLMWSVRDCVAWAADAWLCAQSHLHSCTQRFTQLSEQLNREELQQSRREPNTVDEAAVDGEAMERERLYDCHACVQDIYVAFCVVDAFLRHMSDVSISVKELAEKELPRLVADHIPLWQRPPSRYMQQAMEEYSLLFLDMLRSWTTTRVLRPDTQRRIEEYVRHKLKTVRDAPARPNGVVSDSSGVNGIGTAGRLGGGRLRAVSAGLRMLLSNATAHPQKSAEASPVVAADAARLTIASFISAIFPSSRSEAGRNRCAHCGLVLKNATAKSTHYRYHFCSRSYNTDLKIVRLPYPSLDDYMSHEPDCGETGNFVRVTYDMLDVFRAPENRTVRVRRAKKAPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T3</accession>
    <name>F9W9T3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1894</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001346">
        <property type="protein sequence ID" value="CCD13988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46720"/>
    <dbReference type="OMA" id="YKERFYL"/>
    <dbReference type="OrthoDB" id="1069935at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40420" checksum="83C9145A1B3F21E0" modified="2011-10-19" version="1">MPSCERVAPNQFHSNESRLYTDRCVKELTHSRAFRDYVNHLEYNERIQLMWFVVPIGLTLAIYYHIFFLFPGGCSAKETGAEFSAPLHPLAATLLTLFVLPSTVIAQISGFFEPVPEREVFKLIAYLTFVNISVVSFGGSWTHHPPYIVSHPPVQWLTGTTAQLGEVLWTTTFRALPLQGVVVSTLLVHSWHNRGWRRAWVLPQPLLAVPIIFAFVAWLWYRLASPVCMFLLSATSGSGTEAGVDDVISQIGGLMVKEILLSFSYPPQPNIFSDSLDCCHIWSSALTLSLLYFAGVLVIPIAKSLAGATSWLLPTHPTTWGLLFASCVATFFALIQRDNSSIMLLVALVVIMWSLGRNGFSVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA27</accession>
    <name>F9WA27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001380">
        <property type="protein sequence ID" value="CCD14083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="16227" checksum="AEA33114A7825576" modified="2011-10-19" version="1">MTTIIITIIIVIIIVVIIDTTGRSYAVLVIHKFYFAQIHFPPFFLFNMYRFHRFKITPSPCSPVPRSSFSLSFTVFYLFIEELLARACARVCGETMMMGCQAKGLITLDKGKSFVFFTFIITHYYFKKNIFQYDRGGGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAY4</accession>
    <name>F9WAY4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Thymidine kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_05400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 8"/>
    <dbReference type="EMBL" id="CAEQ01001499">
        <property type="protein sequence ID" value="CCD14410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05400"/>
    <dbReference type="OMA" id="GWLELIC"/>
    <dbReference type="OrthoDB" id="1413914at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="214"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD14410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="272" mass="29529" checksum="118647B64092D961" modified="2011-10-19" version="1">MTQSPQSGRIELVIGPMFAGKTTELMSRVNRNYLASHSCYVIKYSKDVRYSKESISTHDQRTLTATVSVTKLSEVGNAWREYDVIAVDEGQFFQDILEFCSMAANAGKKVIVAALDGDYRNEPFENIAKLIPAAESVTKLSAVCMSCKSCDAYFTHRTVQSEQRELIGGADMYISTCRACYNRLNNQGGSLAEDPKGPQGGVAVSHTVEDANELRSPGADVASVDAACRDSGGSRTATSRSLPDAKLPGKRQRSPLESPSSPVDEKPVRKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB15</accession>
    <name>F9WB15_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001517">
        <property type="protein sequence ID" value="CCD14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50570"/>
    <dbReference type="OrthoDB" id="1729182at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17164" checksum="039D3BD28603A31D" modified="2011-10-19" version="1">MLSNFDLISSWKALKALKTSEAFFRCTICWAGFSVHVAFLTLYLLPRISPGPKLLLLNWPSKTLRTVKIPQPHQRDFSRSVFPRIPRLAPLIKLQPAFVVLVPLMKCGLRALCLMPSIEENKFGSCSLTFLPISTKLYSPKSFLLSSLSSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB90</accession>
    <name>F9WB90_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_51290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001546">
        <property type="protein sequence ID" value="CCD14521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51290"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390095" evidence="4">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="27"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="97"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="425" mass="46552" checksum="A90B8791A20C3EE5" modified="2011-10-19" version="1">MACFVNEISVIIFILLGVVSVVLCQWEIDRDDNIEPFSLLCRIYNVAKNPPINHVDLEEPHKIVEEITALNASLVNDKRYNETEEMANGVEAKINSAATKESVVAQLSINQITQKAHTILEEIKKMNAAENIRKAKAEFAQVIFGDNGNESDLCHATVKGVGDRATACGKPGEGTRGNSAGKNLVVDFFCLCSMRTESSEGAKQACGFFVGKIDKYYGWSEQDPWGSSTMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLKTGGVYRVIESNGKNVEGSDRKEGMLGIGVVKKNGGEKGPVCDGKNGKVGNNPSGVCVYYGKESELDNIPWLKPFQTALASVDTVNNQTASIQRAVKKLQMLLHRAEEIYETAKVITEIQKPVGLPAALQNVSGNLTSYNTTRIRSYNPHPYLIPAWAVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB98</accession>
    <name>F9WB98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ01000000 data</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51370</name>
        <name evidence="2" type="ORF">TCIL3000_7_1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575320">
        <property type="protein sequence ID" value="CCC91318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001550">
        <property type="protein sequence ID" value="CCD14529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51370"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_7_1220"/>
    <dbReference type="OMA" id="RIEVWAH"/>
    <dbReference type="OrthoDB" id="1233765at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="PTHR11960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="SSF55418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC91318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="21546" checksum="D56159DD6B8E00FA" modified="2011-10-19" version="1">MEADAQMKPHPLKDRWFVSYFPVVKRKKNIERDFEEHQKSVELDWVTTAEELFATVNAFSPLTLLPPDDNLVFARNKTEPFFENFPEGVRVCIFTRTRAQADHAVPLVLAAVMGENLRTATGDATCADVVRIAHKPGTVYPESLRVEIWLRDSETDKGTLEYLSKLFIQQPGIRVSNRPIRSTEEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBB4</accession>
    <name>F9WBB4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001559">
        <property type="protein sequence ID" value="CCD14545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51520"/>
    <dbReference type="OrthoDB" id="1752187at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="14120" checksum="47E36BF54CEC6017" modified="2011-10-19" version="1" fragment="single">MKIAVLNYQMALLESDAAKKYAVDAEKKFGPQLTKLKTLESSAKGIQDRLVAGGDKMQQGERERLELEFKQKARDYQFQSKELNEAKAVADREMLKQLKPKLDSAVEEVIKKGAFDLVFERGAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC4</accession>
    <name>F9WBC4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_51620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001563">
        <property type="protein sequence ID" value="CCD14555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51620"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390099" evidence="5">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36185" checksum="02B2ED07B5673B2F" modified="2011-10-19" version="1">MMRKITFWMTVMTSLVLVTGKAHQANTNHNGKEHDLLCGLLGAAVKKWKTTNHPGVKEDLAQAIFGNKNGKVDPGELQFPYSKEYSGNREVYCGKCHGNPEHYPGKSIPHDLICLCTVGTSGYPFVEHSSINQLCGKERKDLGCENCGTSSRITVQGWSTSGNGKTHLENTWNKIVKPCLQKGDTVNVDETLKKLAERRSSDGSPNWGSHHNNCGGHNGAASICVGYSGHCGTNNDYPQWWEKLEKALSTPNLTPTELNSTTFNNNPNHDYNDVPVGQAETSSQSMPQKAASAVHSPEETRTRLLSLSSNQQSSTSLTHPLLCLLSASFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC9</accession>
    <name>F9WBC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001563">
        <property type="protein sequence ID" value="CCD14560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="112" mass="12517" checksum="CB112EF58651999C" modified="2011-10-19" version="1">MVPFSILSNSLENAYEKSEHSTSGVSSIGGDTLFGMMLWKYADFLAPPNSGSRVNGISDGCISICGTRPPKSSTWRYRQCVEGRRCLHSFTSKERSSFLKQRHPPPMPWSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ2</accession>
    <name>F9WBQ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2132</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_52800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001611">
        <property type="protein sequence ID" value="CCD14685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52800"/>
    <dbReference type="OMA" id="MLDMAFF"/>
    <dbReference type="OrthoDB" id="1380051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="PTHR23426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="65"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="20136" checksum="0EE894B5EF1AC4E3" modified="2011-10-19" version="1">MLHRLYAPQRCLAVVGSGQVARTSPVSFFIRGMCVTARGSRRPCTNAALWYATRFHANDSGDRSKPLTLYLQLPCGTTQALTAYEGQTLLDVAGEHGLPIEGACGGSCACSTCHVYLENDEAMTLFDDPTDEENDMLDMAFFPQPTSRLGCQLVLKQKHDGLRLSLPKATRNMYVDGHTVAPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW3</accession>
    <name>F9WBW3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001635">
        <property type="protein sequence ID" value="CCD14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53380"/>
    <dbReference type="OrthoDB" id="1729664at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19027" checksum="F94BDFD14882F959" modified="2011-10-19" version="1">MQSHGGVRFPLRVCVVFLDGLHNYHRCSVSWFYFSCRSYVAFTDLPLCACTFAITISDFASGFVCLFVLFFFFTSSAPLCFCRYMFCFVFPFHSTLLCSSSPPCDILVIITFAFISFYFTAIFPFSPRSNVSRRPLTHMCFVCAALLLRSMLLVLPLLAFIGPQENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC19</accession>
    <name>F9WC19_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_05640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001654">
        <property type="protein sequence ID" value="CCD14806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05640"/>
    <dbReference type="OMA" id="HRGAFIW"/>
    <dbReference type="OrthoDB" id="1319375at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394853" evidence="3">
        <location>
            <begin position="28"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="205"/>
            <end position="233"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="265"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="551" mass="60374" checksum="529B5BFE47FFF460" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC45</accession>
    <name>F9WC45_TRYCI</name>
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        <submittedName>
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        </submittedName>
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    </gene>
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        </lineage>
    </organism>
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            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001665">
        <property type="protein sequence ID" value="CCD14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05670"/>
    <dbReference type="OMA" id="ADHMAPA"/>
    <dbReference type="OrthoDB" id="1626858at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="182"/>
            <end position="223"/>
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    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="263" mass="28732" checksum="1C65EA14561B9214" modified="2011-10-19" version="1">MFGPSDTVDDARTVQLLAEIDLQVERMAKRHGFGPQQGRQWKPVSESSEGAALVSPPKCRFTADHMAPAVRNVSSPAAPMSAEGPEASTFSTLLNRVEMLEERLRVSEEEKSILTRRLASIEQLLGEVMDSKKIMQGGRHASSKHDLEMTPVSYEQDTGAEPSKMRGRKYSLCDCATQSNSSSITGLSAFPSPAKKTPPFDSKRSSAEHGAKNSRCVSTLKSEEVSPTDRQYRIATERRLFALNDLAQRLSFDGLVCGPKSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC91</accession>
    <name>F9WC91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2201</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54560a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001686">
        <property type="protein sequence ID" value="CCD14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54560a"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="45" mass="5111" checksum="76E4D960AE6CD24F" modified="2011-10-19" version="1" fragment="single">LPLLSTTAITLISPLLFYIFLLFFFLHSLATALRRVLFFSFSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCB7</accession>
    <name>F9WCB7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2211</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001697">
        <property type="protein sequence ID" value="CCD14910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54800"/>
    <dbReference type="OrthoDB" id="1692787at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="25832" checksum="D07CAC982F81BBFF" modified="2011-10-19" version="1">MVDTRHDQHVEAADHVAVRSLMRWADLPRAVPKPQAGTTWTGSREYGIPRRSQGTRVMSREETVLPPQEVNVGALSPEWVRRRMEDEALHLFDEVRNLMIATGGTARRDRKSHLRIATGYAHKMKHAGAISHASDLPTKGWVIPFSVVEGRKTGEMRRFTAWPRVKQAKNDYDAEVPLDHMSQCLSAVYDESAALFDLKASFVQVDLSRDIRAGFRYRTESGELVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE0</accession>
    <name>F9WCE0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2218</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001705">
        <property type="protein sequence ID" value="CCD14933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1686745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="29342" checksum="CDE6C3C50FE5E9DF" modified="2011-10-19" version="1">MQQQLEHLQGIIAQQAAQLEEYVRTDATLRQQLTGQGVGVHTEEGERHHGKQDTGNVKRMDEYAWKGFPPHAPRPSSGGVGIRGIKELQGNSWMSGVRPEYKYSYISECAMEYLEDRNPEQLIAAYQYMSPTAATPGPAYTEAWKNFVSWALGLRSEGISEGHLQLGRQLYNQLRTIQTVKDHPGVKIEDIREAVEYPHRKDDVFIQAALKAKKHQTAIPPGRAQCFTCGRVVHYSSSCRVFKKKPESHPTNGFRPRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCI8</accession>
    <name>F9WCI8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2237</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001728">
        <property type="protein sequence ID" value="CCD14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55490"/>
    <dbReference type="OrthoDB" id="1704381at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="297" mass="33587" checksum="395B49AA21070CF9" modified="2011-10-19" version="1">MVLTVIYPQCWIGVGVKVRVRVGVKVRVRVRVGVRVGVKVKVRVRVGVRVGVRVGVRVKVRVRVRVGVIRRLCRQNDGLFYAPVTATRPNGRDRRQTSVQATGAIEAAAEERVVRLAAQKQEATVWEEVLRRKRKDEAETLVATYKQLLLEAPEGMASEVVAEHHHAEHLLQLEHAAKNAEFQTKEEATRAKMWGVFAQVTGEIYRHILQNITGDEKISEDLSTLHMENEAVSPIGANVLPEDLFFTLSCWGHSVAKRFHANTIELCELLLQLYTILRVCIAVNRWRADQDAVTQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCN9</accession>
    <name>F9WCN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001745">
        <property type="protein sequence ID" value="CCD15034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56000"/>
    <dbReference type="OMA" id="PLPYVCL"/>
    <dbReference type="OrthoDB" id="1538795at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17643" checksum="5555FB6644AD4420" modified="2011-10-19" version="1">MQGSWFLTPQMTNPCERPNSCGTRVSTRPLPYVCLKSKDGMEFIIPEAAARQSKMLAMLLDAVYFLPNRGGFEMPEVQQSGGRDHVHANNNINNMPCIPLDVVSRSTLYLVCHYLVQRSTSDVNSTDEFSLLNDLNPLSNEDQDVVVELLTAADFLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP7</accession>
    <name>F9WCP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2256</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_56080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001749">
        <property type="protein sequence ID" value="CCD15042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56080"/>
    <dbReference type="OMA" id="ADEHRIM"/>
    <dbReference type="OrthoDB" id="865289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018680490" evidence="2">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37424" checksum="578E061AD75499D0" modified="2011-10-19" version="1">MRAFVVLSSFAATLVALGTSALRAKDGPVLTQTFVDRINQLNGGMWKAVYNGKMQNITFSEAKRLTGARIQKSRTLPPARFTEEQLRTKLPETFDAAEHWPHCPTIREIADQSECRASWAVSTASAISDRYCTVGGGKQLRISAADLMACCKQCGDGCKGGFPGFAWLYYVEYGITSSQCQPYPFPHCEHRGAQGNKTPCSKYKFDTPKCNATCTDKSIPLVKYRGNATYLLLHGEEDYKRELYFNGPFVAVFFVYTDLFAYKSGVYRNVDGDFLGGQAVRIVGWGKLNGTPYWKVANSWDTDWGMNGYMLILRGNNECNIEHLGFTGFPDPSQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD10</accession>
    <name>F9WD10_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001799">
        <property type="protein sequence ID" value="CCD15158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="102" mass="11940" checksum="E3889127A72CB6D2" modified="2011-10-19" version="1">MNCCGIFRGRETLVYERVVYYQRIIEQSSLTTKSNSHDKDMAHPLPIINPFSESVVHSPLTHFPLLLGDKKSPSINLFSWENNFKLTLRDNHREVNFGGRYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD38</accession>
    <name>F9WD38_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001816">
        <property type="protein sequence ID" value="CCD15189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57380"/>
    <dbReference type="OrthoDB" id="1730276at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17869" checksum="F7A5224942901E5A" modified="2011-10-19" version="1" fragment="single">MGASYFLCSSLEEMDNLKFFCYAYFLLALFPYLSKPPPRSGVPTRGREESFHFFHGQLFIVNLESFILTSYFFPIEEQSFVERNGLLRCEVGMEDGGQSSLYTLHPYHYTKEKEEKSKQITFDLGNFPFYDVHCGWISRKNFFLAKQRGCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR5</accession>
    <name>F9WDR5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001901">
        <property type="protein sequence ID" value="CCD15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59410"/>
    <dbReference type="OrthoDB" id="1088066at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18991" checksum="AAD83A9AC05AA679" modified="2011-10-19" version="1">MFGPLTCRKWLHNYAEHVTEVTPRQNHLPRQPMVVSIPKKENVNTRKMLEPYLYDLPAPKAVAKGEAKQDEPSLWRGDTFSFPFESKESEWSYYLTGSLYVHYWTEARTDVSQWKWSHNVYTSTVWTGTSRYRHEPYVYDPLRDPTSIYPLQEVDICELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDV1</accession>
    <name>F9WDV1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_59750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001916">
        <property type="protein sequence ID" value="CCD15455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59750"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394911" evidence="5">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="43"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="371" mass="40727" checksum="1D647DF6EAFF0F15" modified="2011-10-19" version="1">MINIATLLLIWIGVGTWSGDCGVVLRASGYNEAVSTLLCDVFKAAEAVRKHANVTEELKDKIKVAVYGPSYGAQFTEDGRLSSGNRFISGTQYGRQTVCEYYNRSTRAIRVNGAFVENLFGTFVCVCTPAVTSRNETLCGVLHGERKRTWLGNFNGGRVGNALLQDVWQNVISKCTSDLKNHEDDMTRASKLYLALAAVRNQIPIRRAGEKLLYVLGDARDLRGCSGRDGKDICAAYEYALTKWGIPWVKNLHNLLPELFTQVDNTTETKIEHTVPSRPLAPGTPHSPQSPLSREVPMDEEGEPTVNEEPPGDVENAVAVRGSETQNRESAGEPLEETVKRSEGSPTSQRTDIPYLSTDIHKGGSSRAKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY1</accession>
    <name>F9WDY1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2418</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001928">
        <property type="protein sequence ID" value="CCD15486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60040"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29469" checksum="B5C3057993BA52F4" modified="2011-10-19" version="1">MDSHSRQVGAVDCGDVGSLMRWVVPEPRVEATWTNFQGHNIIRRPQGTRVASWEEETSLPLQEVYVGTLSLEWVRRRMEDEALRLFDEVWNLMINTGGTSKRDRESHLRIATEDAHKMKQAGVIGHASDLPTKGWAIPSSVVEEKTAGRRCGFIAWPKAKNAKNDYEAEVPLGHISRYLSAVCNEAVALFDLEASFLQADMPRGIRAGFRCRTENGELVELKWLPVGYKGDTEIVHTITRALAGGCGGSHNGVRGSKPLENPHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY9</accession>
    <name>F9WDY9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001933">
        <property type="protein sequence ID" value="CCD15494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06160"/>
    <dbReference type="OrthoDB" id="1715011at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16533" checksum="9B2063B4FFBCAEA1" modified="2011-10-19" version="1">MQPGRQIICTNAGNNETHFQCISQYPNTPAPCRGQKPQCGQQLLHAFGLHHVPRVLGCAWCRAMVVTPACGNTGGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE80</accession>
    <name>F9WE80_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001959">
        <property type="protein sequence ID" value="CCD15586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60720"/>
    <dbReference type="OrthoDB" id="1729836at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="20985" checksum="803D9FACA80E5830" modified="2011-10-19" version="1">MPKHTCRGDGTTPLPWWGPPSTPGGNAGPGYTFSKNSKRHIWGAYQKEGKRVIRNLLYPGFHSLLKNFSFFFPKPLSLSESRDFTKFHFLPNSPFSRNSLFYQIPPFAKFHFSQNPLLCQFSLFCEIPFFTKFPFFCQNPPFHEIPIFSKFRFFTKFHFYQIPFFTKFRFFTKFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF1</accession>
    <name>F9WEF1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 258</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002002">
        <property type="protein sequence ID" value="CCD15658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06760"/>
    <dbReference type="OrthoDB" id="1655427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="723" mass="80083" checksum="0AECED51438CB449" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM3</accession>
    <name>F9WEM3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 287</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002034">
        <property type="protein sequence ID" value="CCD15734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07460"/>
    <dbReference type="OrthoDB" id="1711120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21084" checksum="5C42BDDD1EBA4427" modified="2011-10-19" version="1">MQTHIINTPSERPWSMEKDVVEVLLDGVASADKINLYWFLRPVLACLPVDLVIFTLGDFIRNPRHCIPESNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPVPQYQPYQGVVLVGATASFVQVPYSTVGYLVPIPLSPRPWPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ0</accession>
    <name>F9WEQ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002049">
        <property type="protein sequence ID" value="CCD15764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="114" mass="12847" checksum="7FE0FB975AB36950" modified="2011-10-19" version="1">MHRNRTGTHLPPLCRGRGGRVGWTSRDSFGDRSTYHTSCVGFLESRTLGAGPLLNPRCRQFQSLFQKWPFSKLFVMLSLLAHSQKLLQKPPTPCRGPRVCPNCTLAKRPPTSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ3</accession>
    <name>F9WEQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 302</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002050">
        <property type="protein sequence ID" value="CCD15769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07820"/>
    <dbReference type="OrthoDB" id="1662240at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="428" mass="45020" checksum="2474F2AB9444B9D3" modified="2011-10-19" version="1" fragment="single">MRTKTTLTSGAPYKCNVLHSDGYSFLYSARGRRRRQQKCPWCGGFGCPANLHFGCPSPADKFHFSPEVDAVQLTGNDSGVRKRHDGDPLHVSDEGCLVRDGACSQSTRNRVPLFYCLLCGKTLLSAVEFSRHTCCRGGDEISSLNNGVPSVSGGDVLSSPPDGDTSPMGVCKDVKLPSAEVSGVALSDNGPKQRRLPSGGLQKYANNTTAAQDPPIASGEKATRLLKEAVGINDGEQHTLLHHSSPKGSKGASPRVQHSSNGINNHVGSSQHGPPSGGTAVIAIPTASSCTTERKPVSCSEQEHPFLDDVDVSLSSQHSVVVARRFSDRGTGQSSFCPGGPDTSSCCSGSPRARRVQIEDPNGESPRGKSAGFRYAPRMTSHVTFALGVDGRRRSSDARSDTSAGPGRGGGVSPLPFLSHTRGKKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEV9</accession>
    <name>F9WEV9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 318</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002068">
        <property type="protein sequence ID" value="CCD15825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08260"/>
    <dbReference type="OrthoDB" id="1713573at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19474" checksum="B86E36A40BB04941" modified="2011-10-19" version="1">MELHLILPEASLIQSGLPPTRQRFGVMLARHDFVLFYSNQSGKSKPFQYKTEPLMVSALFPFIAPAAICWCAFTLSCTFRYNVVGSFFPLTSNVLTGACFILTDSPSKQTDKYPSSRNQYCLKNSHVSIHKSPSISLRSTLTSASKVVAADGGLPNAPRQMVHLCSEAFHSVQPLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ9</accession>
    <name>F9WEZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002084">
        <property type="protein sequence ID" value="CCD15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="15707" checksum="B0F6E660B8C150F4" modified="2011-10-19" version="1">MQILLVVQSVEGGGGVEKRARTEQINQRRARRKQRNKQTKKKAALLPKEHELHRNIRPPHQLHKQKKPIKKQKVAHRPVDNRPLQSRSEPHFSQRICVVLEILHFILLPLPLPRLVMHYLFLFYCLFFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFB9</accession>
    <name>F9WFB9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 369</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002125">
        <property type="protein sequence ID" value="CCD15987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09590"/>
    <dbReference type="OrthoDB" id="1690232at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29783" checksum="FE44B387086336E9" modified="2011-10-19" version="1">MRALLEGVSARVDTFQDITQKSLAEARERISHVSSNTHMQEALGKDRMNQTQQYSKMVNHIERRMKSECAISRSHATNASKTLSNVLENHCRADGGHHFRWESSANCEHAAGDIEPLSNRHHANGSGFSISCPPKAVAGYDTEASFSAMETALRKWNHSKPVPNLTNVRECNDRGVSGPKGHTEPCTVLEAWLRDYEKTRYSIKRLYDITRTAMGMRRYAERLLNDGKQAIEQQKQRERDLEEERARQQEAMQREAAAMKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC5</accession>
    <name>F9WFC5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002126">
        <property type="protein sequence ID" value="CCD15993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09650"/>
    <dbReference type="OrthoDB" id="1751575at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16082" checksum="A6E01E228E9958E0" modified="2011-10-19" version="1">MFAYDIGWWKGYHPTPNAKTPRGRNAKRCICRVAGNHKEINNNMQTYTRLRAALLPYCTSQSSIVGRATGSLRVRCGFCSGFTTTFAFSAGAAVSVGVVRSGVATTRAACTPGPPEPLSVSICAAMRTAIVSQCRTSSRSAVRSCSHVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFV4</accession>
    <name>F9WFV4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_11330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11330"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390316" evidence="2">
        <location>
            <begin position="29"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="44536" checksum="5DD2B4872529D624" modified="2011-10-19" version="1" fragment="single">MWEQRRMGNGIMAMVVSAIFMCINGVRGGDVSDYKPGHNFNGAEHDVLCEVLKASADLWDASRKTDLKLDNGLEKSLGQALFGKESGGNLEDIKDTLPPEYNTAAHRELMCGWCHHKQPAHPGKSIPHDLMCLCTPGKYAEPFYSYWFFKLIFEETGFKLCGKQQQEMVKDKNDGWYVDGQDKKVVGLQKPWNTVIMGCLKGSVNKTSISKDAEHKILQQKLKRLNTALQEFVNKMVQDNKGRPKFGGKHRDNTESDGKDEKSMHVRYRFCGGKKYGGGRSKTPWWQRLQNSLRMNEEQLIVSRQVTTQASGGSDETEDSEVDETLDAEGEDFPPEEDSNTHTVRTQDSNGSSTHIPTTNSSTNITMGPLNTTEARNSTFPRIEYLRSNTPKNLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX2</accession>
    <name>F9WFX2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11510</name>
        <name evidence="1" type="ORF">TCIL3000_6_3540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575319">
        <property type="protein sequence ID" value="CCC91102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002194">
        <property type="protein sequence ID" value="CCD16202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_6_3540"/>
    <dbReference type="OMA" id="SQHFCDE"/>
    <dbReference type="OrthoDB" id="1480528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC91102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="12829" checksum="F8275DFA17D109E5" modified="2011-10-19" version="1">MKNLIITSTFNPPSFLIVGSPLNEETLRRMEEGIPTVLSTGVSRSQKTSRFMNRDSSNSWAMELSQHFCDELHRAAVALVIIESVTSEGWVLRSSSSSEDSESGKCRITLFFVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG60</accession>
    <name>F9WG60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_12340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002236">
        <property type="protein sequence ID" value="CCD16294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1663238at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395011" evidence="4">
        <location>
            <begin position="24"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="97"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="424" mass="46249" checksum="7F5FE7A5917C42AB" modified="2011-10-19" version="1">MSCLMNVILASTFLCSLWGEAAAQGAEVKSIDNAEQFALLCRIYNVAKNPPINHVDLTDPNKIVEDIDSINASLPEEKHINETEKLENSSDAHVKHSTTRDAAVAQALLSRITRKAHTIPDKIRKVNATRDIEKVKAEFPQVIFGDNGNEGQLCGGALRGVNERDRAKACGDKGLSTKGASAGKKLVVDFFCLCAMRMDSNQEGIDNVCGVYVGSGKKKGNHGWSTVCPSTSSTMWASIKKECGNLLHQHPKSTAEGHGVVDDFLRHLKSGGVYRWGENGKESDRKAGMLGTSLGEKGNNGNDLICDGSKGNNKGTPPGGVCVYYGHGKWNDNINWLKQFKAALATVEDANNQTVSIQLDIQKLQMLQHRAEEIYETTKAISGIQKPIGLTAFPNATTKRLTSYNAAWRYHPHAHFILPWVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD1</accession>
    <name>F9WGD1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002260">
        <property type="protein sequence ID" value="CCD16365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13030"/>
    <dbReference type="OrthoDB" id="373502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43612" checksum="82FFD93A6305F145" modified="2011-10-19" version="1">MVRDAMLLLGDFEANEPRAYLSDAEMEHSREHPAPPDHRAVFDTRERIRSLVFFEQRLLSGGYVNVHGRSVLTHTGDSSCCYDVDEVVLRGPDISSGTTLCSHLVDELVRRFMSGHCTALLAADSRNSASTPLILRNIVHRVLRNKGVRAGCAPALGDLLVSMALVRNNNSVDLLVAKEGGTIHPVEVEISPLLDRRLRGVSYHIVESAEIFDRLLATAVDRAEPALRTEDPGMMVISLNLAHGVQEPVRNVFVSSLMVTTVFDRVSHYHNILLNRPGEPTELFGLALGGPCYTVAALGLCDEDEDTNALLSVLMKLAQVRNRPSRPMGVLQRVEELKKVIQTLGTQLDLEGSDEKKAYIRVKIAHARRFLQEGEALLRLPLGGTCTRQADRVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE8</accession>
    <name>F9WGE8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002264">
        <property type="protein sequence ID" value="CCD16384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16119" checksum="D770F44D4EA5F493" modified="2011-10-19" version="1">MKGGAESSLNPAPARGGESLAELSLCQSLRSFPLVMLKRFVNYEKRNYLLYHLPLTKLNLCKDGRLLSHTPRKKKGAEARGLSITQGDLSGSREEAPCAWCRQQSVLQNVGEILACSKPPKFGVVARNSGIPTKRGQYYLFYLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGI4</accession>
    <name>F9WGI4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 505</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002276">
        <property type="protein sequence ID" value="CCD16420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13410"/>
    <dbReference type="OrthoDB" id="1724759at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17617" checksum="7F2B792DEE21DA8A" modified="2011-10-19" version="1">MVSRADCPVIPAQLELTKKGRTHPGLNRGPFGLQPNALPLSYESSADRSWFACGFFYGTLTEAPKPACCFTSGNHYTKTASAEGPPVLFSSSCSWSLSFTDTSNVYVLNREWRKAPNHRATLSFSIATRVRPAPKQQGSLPSVLPLSEGVGHHVCDPRLVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGL3</accession>
    <name>F9WGL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002286">
        <property type="protein sequence ID" value="CCD16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13710"/>
    <dbReference type="OrthoDB" id="1712162at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19459" checksum="4F42B305058DCE19" modified="2011-10-19" version="1">MAKKDKVGRSQSPEQLELSPERIIITDASTSGWGAIVLDRARHEMTITFGARWPPNSPFTDSGRIAEAEAQALVNAWQELNHKKAKKILFVCDNPVLQYALLMYNSGNTGVEKILEPVLHGLKSQRICWMVQLVPSKENPADEPSRQKGVCQQKIDALLKNISNRPTMVRVKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGM5</accession>
    <name>F9WGM5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002292">
        <property type="protein sequence ID" value="CCD16462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13820"/>
    <dbReference type="OMA" id="CLYKPEL"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="482" mass="56009" checksum="EDA229F5439CB39D" modified="2011-10-19" version="1">MESGTVVHPFIVIGTPGIGKSFATGSLLLYQMLHYRSEDLKVVAYFVEGKAYIFHREERRVVYYKKQQVAVDEVEEMARKGVKGYIIFDMGGSDPIINHLPRSWGIVLITSPNAKKFHDFAKQRQDTLPIYTNCYEDVEFKAALVWERQSQVEKKQIKLEDVNIENDWEVLDKRIRMIGPLPRYALASEATYKKRVEEVTRALLLTPDDVGYYVRVLDNRDEWRKDGITHKLVKLVRCEVNGQLVCRNQTTSVHVRRELLKKLRQARLRKSLIYYVLRGAPEMCAGLLEELGLDIFMLREAVDTLVKYLKHLPHEKEVKRESVLNQRHAEGRVPTIVSEFASDGPKRELETGCLYKPELPNFPLVDGFFVVEGKGPKTIVLLQITRAKEHHTKRTTVHKFRDYMGKVFEDWENIEKSYTWEIIYVQHVDSTAIKKRQNCASSRYAANDTDLALWDRIHQYQVTLNSDIASDFIRHRGDTHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN2</accession>
    <name>F9WGN2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA topoisomerase</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_13890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01002293">
        <property type="protein sequence ID" value="CCD16469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="189110at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="47006" checksum="313FDBD785D82B21" modified="2011-10-19" version="1" fragment="single">MMKKLRPGEDWQVVASGGHIRDLPAKGQDDSMITTGVRKNYTPVYEILDKSGRAVKTIKAAAKQASEIYLATDPDREGESISWHIQQVLAVKNYKRITFNEITLKRVEEALANPRQIDLNRVASQECRRVLDRLVGYLVTQELRRLMGKPTSAGRVQSPAVFLVVLREREIRNFQVINHFGVRLFFADVSRGTTWYAEWQPVPDFASKDVPYVQDINLAQLVAGTRNIVVESCEDRKAERHPPAPFISSTLQQAASNALKWDPDKTMQVAQRLYEQGVITYHRTDNPNVPDEAMEDIRTVANALGLNAVDERRTFKAAEGAQEGHPAITPTYWSERSAGEKDDELALYKLIWVRALASQLEAAIYDVRTAKLLAVGPGGKALRFTASGKTLCHPGWMKVLKGDDTDEEEDAEADNPVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN4</accession>
    <name>F9WGN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 523</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002296">
        <property type="protein sequence ID" value="CCD16471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13910"/>
    <dbReference type="OMA" id="NRRRTNY"/>
    <dbReference type="OrthoDB" id="1666458at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="612" mass="65716" checksum="CD280FE2C690B303" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN9</accession>
    <name>F9WGN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 524</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13950"/>
    <dbReference type="OMA" id="NAICYIM"/>
    <dbReference type="OrthoDB" id="697331at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="66"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="469" mass="50101" checksum="142995692FB3B95A" modified="2011-10-19" version="1">MSSAAPNPVPAGTEPVELTAVGCKGNDEQRHDTNPTPKPEDSKENVGCFAKVAAFMAIVMPPGGIAASAFNISASTLGAGIVGLPAAAQSSGLVMAMFYLLIITLLCIFTMHSLAVAAEKSNARTFEEITHKLLGRGASYFLAGIRAFHGFSGCVAYVISTGDILSAFLKDNNSDFLKSNSGNQLLTSVFWLCCMLPLVIPRHIDSLRYVSTFAVTFIVYLVIVITVHSCLNGLPENIKSVSVGKDESAEVVLFNSGNTAIEGLGVFVFAYVCQVVAVEVYMDMKDRSVRKFVIASTIAMFLCFTLYIMTVFFGYLDFGSSITGSILLMYDPMNEPEVLVGYIGMLVKLCASYALLGMACRNGIYSLIGWDADTVAFWKHCIAVVSLSVVMLLSGLFIPKINTVLGLAGSISGASLSFIFPALLIMYAGGFTWQKVGGFYFIVTYIVLLIGVFSLVFGTGAAIWGTING</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGR6</accession>
    <name>F9WGR6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRT6_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002309">
        <property type="protein sequence ID" value="CCD16503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="12770at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRT6_C" evidence="1">
        <location>
            <begin position="35"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16766" checksum="9CE402415CA64451" modified="2011-10-19" version="1">MRKGFHLHQCVAECYSASTRMSHAVCAVIPPGVRLLCCFCGKPLCLKPPLTPPELYAHALSCGNGLGIYFSTTKNSFFVFYTPRMCYTVLPGPYADEHGFRSTRRLCSRQVSLHDGQVMILLSLWIRSRWSIEFTVVSRMDRISPQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH12</accession>
    <name>F9WH12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 580</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002359">
        <property type="protein sequence ID" value="CCD16601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15110"/>
    <dbReference type="OrthoDB" id="1658676at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="587" mass="63745" checksum="E73162400E665041" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB0</accession>
    <name>F9WHB0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002408">
        <property type="protein sequence ID" value="CCD16700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14872" checksum="288499A68925D16C" modified="2011-10-19" version="1">MVPIGTSSFCFFSFPKRMRTRENSNPTQSLKRDTRNTFQNSSDARSPSQRASSPFSMKDVTASWKHPRISSMPIVAVPTTLATINFPIRAFLPFLIPGPRSPPLHFLPEAAHHNSTGKRERSRSHRIHRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB9</accession>
    <name>F9WHB9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_16170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16170"/>
    <dbReference type="OrthoDB" id="1669030at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390335" evidence="2">
        <location>
            <begin position="25"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="43096" checksum="DDED94C96C681A3F" modified="2011-10-19" version="1">MLQAMKALGVIFMMSVLCSEKVWGVPYSRKAIPTEAGESICSLSRKLKDVSPWTQGLLETLKKTQEVYASKLLDWQLHFHGSSECELNQSILDNIRTDLEKVNKEIQKLSGKAILAGALAAKSAGRLDEFITVFANAQKGSTSVFDVSSSNAGSFCLGGKGDPARRRDLLDCFPDGEKLEIKEGNLAKIPESVPDKSEINLTAALRIVNHSILEAHFRRIYWDDIHAGCNLVNGKDGILSGTLNDKLWWGGGILTIGKSFDGDLSKVKSSKDKESNNGDSAATWTSSPHNVPHLQKTLATFQDFKDAASIITQKFSEIEKIEKQIEPCLSNETTEQGPTQSCFQSAVKLNAELQAANALLARYHKEKGPLPSGSTLILHQSLFNVCFYFAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC2</accession>
    <name>F9WHC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16200"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20039" checksum="336AAFD1DB462128" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKGIGKPEGINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCKMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD9</accession>
    <name>F9WHD9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002418">
        <property type="protein sequence ID" value="CCD16732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16370"/>
    <dbReference type="OrthoDB" id="1711119at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21204" checksum="7AB0202313959970" modified="2011-10-19" version="1">MSLYTITSPNQRPWSMEKDVVDVLLDGVASADSINLYWFLRPVLACLPVDLVIFTLRDFVRNPRHCIPAANVCDTLWQYLPYILWKFRLSATPLVKHFGPTQTWNEWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPCQEVVLVEAAPAFIQVPYSTMGYLVPIPISPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ2</accession>
    <name>F9WHJ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 656</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002444">
        <property type="protein sequence ID" value="CCD16785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16850"/>
    <dbReference type="OrthoDB" id="1703324at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23140" checksum="45F28824140149FC" modified="2011-10-19" version="1">MFSSASCRAINTHWFAVARNFGPRHPHSETSCHVMGLQNRQRPLEIQLHQLSPTRSSIVQTKGLQELQGLPVSRIEFMVEPIDGFTRLLLHRMTREIKASEEENPESYPLTVARGGVTSIPRGTMPTGRFKFLKELRCSLPSYKHKDVIVESARRGAVVVVIPHPMIPPTSQPASCSSRHISPFSQSEPGEGVSNGPFLLTFPVPPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHM7</accession>
    <name>F9WHM7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 674</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_17190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002463">
        <property type="protein sequence ID" value="CCD16820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17190"/>
    <dbReference type="OrthoDB" id="347707at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="373"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="438" mass="49481" checksum="33DEAA056F64884C" modified="2011-10-19" version="1">MSRGNVERTRIPVPNNGSSFIQSDPKVNGTTDGLLEKQVTFCQEEGCSELLSLTHVASPRHRAPMENGVITTEDIILSERYAKKRVFQKWWLRTKNRRNNALCVEFLRKRLNDLIATTCPTSQSICATLGLLPRSERKRVLFRFWYDQACSLYMPRSFRLGTLLMRWRYRTYKLCSAKFAEAHYRSMTKRKVWSRWCKHTQLRNNAISNGLHSSPISIEKTLSAPIPQQVNGEVGLNLVPGPDLCTKETKPMTTRQTQADFTIMEGEGLHPSKKESPKGVTGGSRAPQCEGTPNVAQRLLLPMATPSPPSTVPAQHPGSAEMATQTAFSSPPSCPATPAGQTPIHVDTEVAVAALLEDRVRLVDRIIALEMKVNEEAVAVQNREREIRDLKQKLNFMVMREECIESTVKDYQQKCEHLQAVVHALRTERRETLLSTMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI24</accession>
    <name>F9WI24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 722</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002517">
        <property type="protein sequence ID" value="CCD16969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18410"/>
    <dbReference type="OrthoDB" id="1731580at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17966" checksum="B9FC6B335C27566C" modified="2011-10-19" version="1">MIILPILSFITVRMCHTPLHNNTKQQLPSGAASKRVPTTEFRLSCVGSFNYFITLRDHIPTFISKSTVCVKFLTCFFHNLTPTIIFPYASHIIALSKHKSGCVLGKIILSCWFSNAGIWGSYASGLILVSFLVFVVLFSMWFLLTVRTNFKVASIITKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI81</accession>
    <name>F9WI81_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 743</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_18880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002540">
        <property type="protein sequence ID" value="CCD17026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18880"/>
    <dbReference type="OMA" id="SEEHDYR"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48231" checksum="743996A3C9BA1689" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGKAPEAVDWRKKGAVTPVKDQGKCDSSWAFTVIGNIEGQWKIAGHELTSLSEQMLVSCDTNDLGCRAGFMDTAFKWIVSSNNGNVFTEQSYPYASGGGNVPTCNKSGKVVGANIDDHVHILDNENAIAEWLAKKGPVAIAVDATSFQSYTGGVLTSCISKEVNSAALLVGYDDTSKPPYWIIKNSWSKGWGEEGYIRIEKGTNQCRMKEYVSSAVVSGPPPPPPTPTFTQELCEGAECQSKCTKATFPTGKCVQLSGAGSVIASCGSNNLTQIVYPLSSSCSGFSVPLTVPLDKCLPIVIGSVAYECSDKAPTESARLVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIB4</accession>
    <name>F9WIB4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 761</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_19170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002560">
        <property type="protein sequence ID" value="CCD17060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19170"/>
    <dbReference type="OMA" id="MFHGFPQ"/>
    <dbReference type="OrthoDB" id="846640at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="JAB_MPN" evidence="3">
        <location>
            <begin position="114"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="34623" checksum="504498AC928B8491" modified="2011-10-19" version="1">MLLLASLRGCVSREGEISRNEAHPFCCTSLFLVPSFIYLFLFVLLRLSIIYFPVQQSELPFVYINLEFHISQAVMFHGFPQVQVQLSAADVPVDLRFHRDDEAGCVKTIKLQPVQRVRISFAALTHLGSLAQNATCHHAVFGELCGVQLNDTIEVTNIIPAVSAERTNEDEREDQREKRMAAQQQEEKQMRGKLEKMLRNEVLDSYNVGHFTVCSACANAPYSTRTAHQLAKLALDGHPSVLIVYDPFRTDLMGKLHLRAFVPTAEYIDFYGKFTSKRNALRENRLVRDCRVTKHGVLREVGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF2</accession>
    <name>F9WIF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 780</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002581">
        <property type="protein sequence ID" value="CCD17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19510"/>
    <dbReference type="OMA" id="RNCAQCH"/>
    <dbReference type="OrthoDB" id="578726at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1140"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1173"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1233"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1254"/>
            <end position="1269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1283" mass="139969" checksum="CE21B2AEC9E98263" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK0</accession>
    <name>F9WIK0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 805</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002608">
        <property type="protein sequence ID" value="CCD17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19950"/>
    <dbReference type="OrthoDB" id="1715148at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18997" checksum="8B6A671C3CDD0CF6" modified="2011-10-19" version="1">MIFLQYFLSLCVPVYVGGASIQMVSLLFCFCKTTGGGNEKMEHSVFLHLYSRLGCFVFICLREQHNTPTFDVFIFIYTYYPLTHVVRLFPSLNPLSVWSLRFPSLQILKRYRQKLRFSSRLFSWTVHRFVIVLALPCALGTLLIRYHFPPFTPPLVCRDVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ7</accession>
    <name>F9WIQ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 822</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002627">
        <property type="protein sequence ID" value="CCD17205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20420"/>
    <dbReference type="OrthoDB" id="1705031at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="21929" checksum="7716CE36FAFF1C7C" modified="2011-10-19" version="1">MERPPQRNSSTPVESVDNWVRAGEQIEEFVKKIESAPDAVLWKKEWGRVEALSRTLRELEPARVTTNAVSERGSQIADFWECFQKGLASRVRDLAKQAVGGVARALATAENIVGKLESAERWAKRFDKVFCCCARPPEQAAKAANELKRVKEFLKVLESLLKALGVVVKATEALCTSAVRAPDFVRALGAIGKPLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIS2</accession>
    <name>F9WIS2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 825</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002630">
        <property type="protein sequence ID" value="CCD17220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20570"/>
    <dbReference type="OMA" id="DEINADW"/>
    <dbReference type="OrthoDB" id="1532459at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="2">
        <location>
            <begin position="52"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="18262" checksum="CD94F3306ACEDAEF" modified="2011-10-19" version="1">MKLILAESLSFRTALLSFVCGSLAAMFLELLLRRWRRREQLVPTSIFIPRGYTLEELAAYDGVRKPYAFIAVRGIIYNCSLDFYGPNAPYNAFAGRDSSRNLGKMEVGQQEANIDWTTLSPLHLKTLFEWETRLRSKYEVVGWVIAPEDFCRSSEKVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT5</accession>
    <name>F9WIT5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_20690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002637">
        <property type="protein sequence ID" value="CCD17233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20690"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="43297" checksum="8364B992D152BFC1" modified="2011-10-19" version="1">MAKNVRMRVMQKPRRPTGKLLLLCAGIVSLIIILCVLWGTSGCQPNTATEKDSLTPINYDTYLRFIPPDVVSTWKAREFLVVMGIPSVDIDARQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRRRIGEGGSWGFQSEVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRASLLWTTDDIVFAAGYCTTLSKDAAQAVVSYKPLAALLSKPYSIWHMMQYSSMSVMHEDIMVGRVLREKIKLDNLITIDVGRCRFHDVPNKTKVYLTNNSVVLHHIGELHYFKLLRHFPTNATPPAPSPIRWVNGYTAILPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD2</accession>
    <name>F9WJD2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002712">
        <property type="protein sequence ID" value="CCD17436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22550"/>
    <dbReference type="OrthoDB" id="1697026at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25166" checksum="B8A88EE7CE31D236" modified="2011-10-19" version="1">MQQNSSTIRKTCPHCFLLYHHPFFSPILAFSIRIPMSFYTITSARTIPWSMEKDVVDVLLDGVTSADKVNLYWFLRPVLAGLTVDLICFTLGDFVRNPRHCIPESNVCDAIWQYLPYILWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYFDNDDTPLEAIDEEIWRRCRRPPPPPYQPCQEVVLVEAAPAFIQVPYSTVGYLVHLPVTPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI5</accession>
    <name>F9WJI5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 914</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002729">
        <property type="protein sequence ID" value="CCD17490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23080"/>
    <dbReference type="OrthoDB" id="1655167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36804" checksum="9F7B48706FE44C46" modified="2011-10-19" version="1">MLKERIDMVGPLPRYVLWSTAMYAHRLRGVKNALELLPSDDFEYYMGMLDNPHKWYEDGTTHKLVKLVRCKANDEFECRNRVTSIYVREEIYRKMLVASIKASKLREILSGAQEKCADLFEIAGLRAFLDKTTVDTLVRHLKYLPRNKERKRQSVLSQRGANGRVPTTLFEFASDGPKRELKTGCLYKPLIPNFPLVDGFFVVEGKGPKTIVLLQITKAKEHHTKKTTVREFRDYMGKVFKSWKRIEGSCSWEIIYIQHVDSTAIKKRQQCASSRDAANDTDLALWDRIHQYQVTLNSDIAAEAISRGTGLLKVQAASDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR7</accession>
    <name>F9WJR7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 942</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17160</name>
        <name evidence="2" type="ORF">TCIL3000_0_23860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002461">
        <property type="protein sequence ID" value="CCD16817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002760">
        <property type="protein sequence ID" value="CCD17575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23860"/>
    <dbReference type="OrthoDB" id="1701028at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21560" checksum="EC8D5B6D0B0E0779" modified="2011-10-19" version="1">MQTHIINTPSERPWSMEKDVVEVLLDGVTSPDHVNLYWFLRPVLDCLTVDLVCFTLRDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYFDNDDMPLEAIHEEIWRRCRRPPHVPQYQPYQGVVLVEAAPAFIQVPYSTVGYLVQLPVTPRAWPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3B5</accession>
    <name>F9W3B5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1032</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_25930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000387">
        <property type="protein sequence ID" value="CCD11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25930"/>
    <dbReference type="OMA" id="MSEWHSE"/>
    <dbReference type="OrthoDB" id="782733at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="24953" checksum="74F2FCCBE9928908" modified="2011-10-19" version="1">MSNAVDALLTRLKIPDLIPKFREMNVDRIVNLRKLSEEELRVAVPDDDQRNLIIQAIKNRGNNDKKPQSLSTNITIPCATDEGGRRGMSYPRGVSRGGGTMRGRGGRGSGAVMDEDGAYGSGNNSSFLSRLRVCNNYLAGECKYGDNCRFSHSRTGQDAVENVHRRDNDMTSMSEWHSETCVIPTNRIKFLLANRAERLRAITARTTHTTNPSNTLTLPSRSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F3</accession>
    <name>F9W3F3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 104</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_02870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000403">
        <property type="protein sequence ID" value="CCD11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02870"/>
    <dbReference type="OrthoDB" id="1729095at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389840" evidence="2">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="21680" checksum="0C4C708D1DA145F8" modified="2011-10-19" version="1">MPEMSCSGTFLRICCLRVGCTALVPEARFWDRTRLPQPFAWHSADRRLWRGLLGFLLPTVSSKCSNTVTSPSEWTHLRVFRLPPAMNGIPEGFHILLHFYLFFPASSAAVVIAVALPRFWLPSLLSSYASPFCTNHLPILFRPLRLLPHTPASSHAAALSLPNLLICSIVNEFHRHLLKRSGQDSASCCSHPHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I0</accession>
    <name>F9W3I0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_26530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000412">
        <property type="protein sequence ID" value="CCD11698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26530"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389842" evidence="5">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="47"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38400" checksum="FFDB6D03C746E86F" modified="2011-10-19" version="1">MWGNVMIFFVFFRYLVEAVHCHNELEQELLCDIFRQSERVLQKFEDDEPLKQAIYGPTDNNAQIIKFGNVTLGTSCHGPVLRDQFCRYHGSKRGKDGCFAESLLGTFFCICAPGARRGYVDNLCGVGIRRHVDSWYGYTPQREDEIEEIFGNVWKDIISNCTGGSESVESGNEELEKLRKAVEEVENTIKPDRNGFFYNLGWSGGKDCSGSDTKDVCAAYQKKDGSGSKAHIPWMEKIKETVTQLQKMERERQYLDTRKRTTGKNSESMTTLTHHAEGYAELTVQSEGTVTPPSSDRTPSKTKISTETSPITNIPHLATDLNEDGTPLTNQKWLVVAALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M1</accession>
    <name>F9W3M1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1076</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000436">
        <property type="protein sequence ID" value="CCD11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26950"/>
    <dbReference type="OMA" id="PFMANDA"/>
    <dbReference type="OrthoDB" id="1655926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="726" mass="80360" checksum="01B550BC12FEA284" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P2</accession>
    <name>F9W3P2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000447">
        <property type="protein sequence ID" value="CCD11765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27120"/>
    <dbReference type="OrthoDB" id="1268334at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="907" mass="105544" checksum="3CD37EB66F9E5CA8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P8</accession>
    <name>F9W3P8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000449">
        <property type="protein sequence ID" value="CCD11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02960"/>
    <dbReference type="OrthoDB" id="1267343at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20048" checksum="21A5E0550D9B65E8" modified="2011-10-19" version="1">MTADRGAADEAGKTTDAVTNNNGNNDKSENNDGAERCRNISGSEGEIPDGQDGRVVPVHGSAEDSLALGQTQASGAQGQGTYSAEQLINQEIPLTTAYPERRIVHPGNHEERIPPTGGSEYNGTVTEPWKEPKSEANTYLRLMPTYESTTHYQLRTGRYYTEDQAPPHGMKLPLKTSLFKREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W452</accession>
    <name>F9W452_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000514">
        <property type="protein sequence ID" value="CCD11936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28730"/>
    <dbReference type="OMA" id="KCASTRI"/>
    <dbReference type="OrthoDB" id="1282076at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="536" mass="57771" checksum="97DF90F7B988E178" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W478</accession>
    <name>F9W478_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000526">
        <property type="protein sequence ID" value="CCD11966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00200"/>
    <dbReference type="OrthoDB" id="1713087at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19917" checksum="3FBC232A02D1D2A3" modified="2011-10-19" version="1">MASFTQTFQYLLPLGYWVPTVLGSTALKYITPRSAAAIVFWVVCCMQSCLWTTGRSVQRTKKYVMLFSLSMLLHLRQEASEGAPMSLKLTFFFTFSMEMGHYVIIRTHIQVLLVLRDVAHLTQRHRCGGDPAAARNVTHYEMEKCGSGIVETLTRVFFFTKRFLGRLLGFLEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4E0</accession>
    <name>F9W4E0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000545">
        <property type="protein sequence ID" value="CCD12031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="14760" checksum="959EA0D09C874A69" modified="2011-10-19" version="1">MGFILVQYEDAGGLGKEEIVGKSGGFCPKPLKPSSARYPRGDGGARPNAGAGVPVLVVVSQARRQYLAECGGVKRGPTAEGGRGPHSVIQPPRRPSQVDRNSTPMWSSWAWSSPDAGNEPLHHRHHRDKRSSRKLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4I2</accession>
    <name>F9W4I2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_29950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000559">
        <property type="protein sequence ID" value="CCD12076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29950"/>
    <dbReference type="OMA" id="NRTTYIN"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388655" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="867"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="911"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1084" mass="119284" checksum="91AA9E87FED16973" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4M4</accession>
    <name>F9W4M4_TRYCI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14444" checksum="5C9616675C3DD312" modified="2011-10-19" version="1">MTNPVTSYDSGCLRCDVWSHLQWARSNMPRFGGWTSSFTFCLGGCAVRKKTMRIIPEHTPGRWTPTAIHGSARNNNMHNTEKLHGAKRCKRKGSGMFILPATYRKVNGIQKKLGYDYAHLIFPFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W539</accession>
    <name>F9W539_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000655">
        <property type="protein sequence ID" value="CCD12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="17418" checksum="0EE3FC18D079D41B" modified="2011-10-19" version="1">MYACSLICCFHYFLSFVVWCLWESSEDDQWSGGRLTYPLIATATRIAAWRVVSKLFAKRIVFLLLPLIYALIRFSFSFHFPESLHYEMVSELRFHSINSCRFPYTCTCTSAYIIRLFEGACEFQKCKFLFHQRRSLPHVRPSLRWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W564</accession>
    <name>F9W564_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000664">
        <property type="protein sequence ID" value="CCD12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32050"/>
    <dbReference type="OMA" id="DYLDWLY"/>
    <dbReference type="OrthoDB" id="395119at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="736" mass="83034" checksum="612CD6F9F2A5F222" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W572</accession>
    <name>F9W572_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000667">
        <property type="protein sequence ID" value="CCD12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14860" checksum="FECC6E47338C6738" modified="2011-10-19" version="1">MHPPKTNTTVCAISLPLFVYSPHGDGKPHRHTHTHFPIVSPPPPPPRHTLHIRLSHFSPLYARLLCLPCHSSPLLPLLLLFSFSFFLWIVFFKKNIICSPLLFDGFFFLSSLGENSLKTQISAHPHIHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5A7</accession>
    <name>F9W5A7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000686">
        <property type="protein sequence ID" value="CCD12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32410"/>
    <dbReference type="OrthoDB" id="1700662at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="201" mass="23397" checksum="1C569C093AA3004E" modified="2011-10-19" version="1">MTGVPMTTQEIDYSSDSQHPTVLPLTHDNIVTHVLDRKSYSKLKYGEIMNIFEKRAEIAWQKMEAADRAKEKGYVENENTRGIGFYRKSETLKKTVYEEIDIRQTFKNQPDIVHELGQMFHAFRMTFGDLMVYILLCRIRQLSGEPGPVPHIDKIAYRATKPIKEEGDKAWDKYWEETEKKYGVTNDREYANGGGAEVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5C8</accession>
    <name>F9W5C8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1311</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000698">
        <property type="protein sequence ID" value="CCD12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32620"/>
    <dbReference type="OrthoDB" id="750317at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="2">
        <location>
            <begin position="114"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="46152" checksum="64366D5CB5E84DC6" modified="2011-10-19" version="1" fragment="single">MRWTIRLLQQSGAPVSPLTESCVTRELSTKNIRRPKKIQRKIFVDRLRRQSRARARIISAQEQSQLSTVTSSDLNGRDVVMAQLADEIFSRGHKHMCCATNISFVPDGNPATPEVALAGRGCCGKSSLLRSLFRASREVARSNVKLRRDAMNFFNVGSGIFNIVDLPGFGGTSVPWSTVLQHAVLLRNFVRYRPSLKMLYYCMDVHYKHGVYTRDIDMLRFLSKEVPNFTIVVTKADQLDVTKSKDVFRLEDIRKELLFHDITHPVLVTSAYHMGGIDALRFDMVMNCMHALPTERLTITEAKRLSERLLSQRELATVRQLSIPPTQLQDDLKEWEKELEEERAAEAISTCTSGEGRDGNKSAKSTEGCTATDDTEATHEKSPQPVVTLSDSVSVSNDSREAAQSTAFKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J9</accession>
    <name>F9W5J9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1334</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000723">
        <property type="protein sequence ID" value="CCD12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33300"/>
    <dbReference type="OMA" id="NSGANRE"/>
    <dbReference type="OrthoDB" id="1250176at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44308" checksum="18D3150F1224E150" modified="2011-10-19" version="1">MTPKSKKKNLTPKVASATPTRSHTSTSMSMQSTNSGANREGAANHTRRSQTSVRSGTPPPPRLSQSIRSGGASAGEGTHSTTRSTRRQTSLSRGNTPRGSVNQGSVRSGTPGKQSNGRGATPNPNGSLQEMPISQLLSRLLNNTRLGDMRPDICRFDANSKEDVRYLYEVQHRAYPEFRSVTRRGNTEIANRMLRSRVFDFINEPEPPAKPPQAAKSPRALKSDDGLGALTRFIYSAEGRPVSPHGRRRCLTPSNRNAVVSDPILCKGHPLTPRLGKYRPPVRTQSNLGRDLVVSDQSAEAATPRPRIRSLSGVRTFEARQPALTIPPRRKAGICISALQDHVANKDNDIFGVRRRREYDEQQRRVRVESAARSVSPRVARSLSIEKGEETPAPVDWALYSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5U8</accession>
    <name>F9W5U8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_34210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000774">
        <property type="protein sequence ID" value="CCD12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34210"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394563" evidence="6">
        <location>
            <begin position="19"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="83"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="430" mass="49372" checksum="18CB30C548BD8160" modified="2011-10-19" version="1">MLLGKFALLPLVVSMGMASSRHPSAAEFNLFCRILGKANDMIYGSNYVYNEDADRAIMREIEVLYNITTGNMNNFGKMLWKTKDFLTDYPPPTDPKNREEAHREIGKLIKDGEKKIEENKKIAEEVNQKIEEAKLSVAKGLYGEHVTVVPKDDKNLAEILNNTGSTFEDNKSAADSCGNVSTKPAGKTLINDLFCVCAGVGDNAEGPCHPKIWPPKSWKDKNGKWTLIKFGLSKDKPQLIQSFNESFQKIEHVCREEMIKRNVKPKNMDALLREYLWMIEMGDKKTKKEKKIFGHSERNKGGKGKNQVEKCDGSQGSWDYDDPEKNNNNICVDYTKNQNKNDKTYNITWHEKFRNYTEIMREAKKIEERILENHAALLLLKSQAWVAYSREKDDETSNLDDMNMSHLFDGTKIPFSFPFLFLFTFLFMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W691</accession>
    <name>F9W691_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000837">
        <property type="protein sequence ID" value="CCD12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="15797" checksum="71EBB4C5E7B6B44F" modified="2011-10-19" version="1">MGVLPQVKWVALGRWLHEDMVLFCLLQETHLTSAECAALKIGGYQHVGQARTPNEGGVSILVRDGVGVEVGILEEKVPERARVTLRFSADVSLTIISAYFPGRLMLPARRWTPWPERADVNSHRVLWDPLRLSGAKGECIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6C9</accession>
    <name>F9W6C9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000849">
        <property type="protein sequence ID" value="CCD12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35910"/>
    <dbReference type="OMA" id="CALELCP"/>
    <dbReference type="OrthoDB" id="1662723at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="429" mass="48852" checksum="926B35D5630198B2" modified="2011-10-19" version="1">MINKGIVGYIIFDISENSIHIGDLPDNWGIVLISSPNVKNFHEFTKQRQDTARIYMNCYEDAEFKAALVWEKHSQVENKQIKFEDVNLENDWEVLGKRIYMVGPLPRYVLGDGECFRRRVIDVNAALSTILDEDVNRYARHLSNKVEWYVDGTTNKIVKLVRLWKTCPEEARNEAVSTYVRERILRKAMENFAKLTISLSELVTTREWCAYKFEMSGVLAFLIGSVVTEVVRHLKYLPREGETEESRSSVLARVGASGLLPTSVHQLCLHDKPVEMVVECLYQPAEKNFPVVDGFFLVDAVGEGVPFPKGAEAPTQTIVLIQVTKARDHHTTTSKVKAFRERMVRYFTNWTEMESRLSYEIIYVQHADSTTLAGRQRCARSGVADDTGIEKFWSGIHQFLVKLEAPIAKLILQDMHNVATAEVTGVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R0</accession>
    <name>F9W6R0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_03695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000917">
        <property type="protein sequence ID" value="CCD12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03695"/>
    <dbReference type="OrthoDB" id="1670266at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394586" evidence="5">
        <location>
            <begin position="22"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="85"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38955" checksum="C36D9B1741D5FA45" modified="2011-10-19" version="1">MMLKLWMVFCLLGVGMVCVYGDKKNHNGDEHVLLCKVLRTAVFSYKSNSGSRAEAHVTYNYIGSEDEGDLETLKGTLPGNYDVQNGRNRGIVCGQPPDGSSRTGEKPRWPGHSAPHDLLCLCTVGPDGWPFISGTSIDSSHDTKLCGYTKEVLKAEGNKGWTINGSEGKDQMTATWTNVTKKCLEDDGQGGELKEALKQFIDKLSHTGDSTYQDMHRLGEGDFSKYPCGGNKKLCVMYYNSTQYEKLMPWWVVLAKATQNEVQKQEKKKDNKAENLKQNAQKQRQPQEQDQPLPQHEARTAALRSAPQDSQENEQSNPENFSSPLATSEETSGTFIIPPCTWFLGAFLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6S4</accession>
    <name>F9W6S4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000925">
        <property type="protein sequence ID" value="CCD12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37200"/>
    <dbReference type="OrthoDB" id="1703736at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22497" checksum="B0252AF9022E29E7" modified="2011-10-19" version="1">MKVSVTNGPHSHCHTARMALPPELTATLHHWRQHLLQGRAAKVSWHHASLPATNTARAIFSCVLHTNAHRNKSRSSCTASSSTSKQIAFRVDIRRPLLTVMQYSSPSGTHTKPFHSLRKSKSSEVKAALRQYGPFDIAALALCVLRPHYVTVLTLRSYSMAQAAMHTNDMQRCSAHGGSMPLPTPINQVAPSHPSRSHHCHLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T6</accession>
    <name>F9W6T6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000936">
        <property type="protein sequence ID" value="CCD12893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37310"/>
    <dbReference type="OMA" id="NVAMEIF"/>
    <dbReference type="OrthoDB" id="1654514at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="820" mass="92094" checksum="938044A29664D1C7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W787</accession>
    <name>F9W787_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000996">
        <property type="protein sequence ID" value="CCD13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38680"/>
    <dbReference type="OrthoDB" id="1554048at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0675">Receptor</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388755" evidence="1">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="421" mass="48147" checksum="4D7E0EFAC323E7C6" modified="2011-10-19" version="1">MCDRYIFLVVVMLVGDVMVEARDLPALKLESAQGACAVSRLMKSMYNFVSSRNKEAQEMYESVERMYDLGRVRIAQHVLENGECDRMTFFVLFSQRIKENMTRKIRELASAGVRLVGAAGLAAGRLDEFINIFRHSWHVQTTHIYSTTYNHTYSFCLRGKGTKPVDKKSIVDCFMNDKETDDNGFVPVDGGDVHWLDQDDMGSLLDMRLKLVDGDPRDEHGQDRSCVLLSMEGNDGYLGKGNKGKKVLWADGLLGVTSGHAKKSGFTGSVRSSSYSTNIMWEAKPSSSIPVLKDFVVRYNDYRKLFDEVKHLSAAMTDDWTVDHLMKYAEGIASLLYKPEELDVLLSVDENEDNETAEEDQRLLRLRHTVEPFVGLNDRKQEWLAQYNKELVSKEFLAAEIQLCRSAAELHLRRNRWFFEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P1</accession>
    <name>F9W7P1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1635</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001059">
        <property type="protein sequence ID" value="CCD13213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39830"/>
    <dbReference type="OrthoDB" id="1665318at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388775" evidence="4">
        <location>
            <begin position="25"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16823" checksum="C29CF14E52B27BB5" modified="2011-10-19" version="1">MMIMKIWMVVCLVVARGWVKEARAQADMTVNTSDNVEPFSLLCRIYKVAKNPPIKPVDTKDYQRIVEEIDALSASVSGYERVNPKTETEKLNRQKLTEIAGDAQKIWDEVKKVNLNGEAENAKDAFNKVIFGEHGVSETDLRHGAFKGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7T3</accession>
    <name>F9W7T3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1652</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001078">
        <property type="protein sequence ID" value="CCD13255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40240"/>
    <dbReference type="OMA" id="MRVWHIV"/>
    <dbReference type="OrthoDB" id="1667860at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40549" checksum="7503EE635249EB40" modified="2011-10-19" version="1" fragment="single">MLRHVGVAARRTAVLRCRALWAHVGTFPQAPIPLQLSRRTVFHSTQALRSVRSYEQKTPQWTLDSPVKEVLLEDSAGLSDMSLHDFLMKHFGETFGSPCVSMRVFMGNPSFFLRDESLLTMVTESEPYREYKTMREGVDRLSAKGIISLRQWESAAAANEVEDVGAYVRGVLNAALAIATGISNAPSGVEIDGAYDAVFNARWSYVVRSDEYDKKWLGMGVLDVAPGEQPHLWSEAQADVPYDPKELWEGDEVPDVSGKLVMAVLSSERGWPYGFFQRNEMPDTSTLTEYDAACDAYIRRENLRVWHIVKKWLGMWMESGRVVRPFIVIGTPGIGKSFATGSLLLYQLLHYPSDDLKVVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V5</accession>
    <name>F9W7V5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001085">
        <property type="protein sequence ID" value="CCD13277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40460"/>
    <dbReference type="OMA" id="THALPEV"/>
    <dbReference type="OrthoDB" id="34077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="PTHR16453"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="794" mass="86189" checksum="2CA0866D01C42AAE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Z2</accession>
    <name>F9W7Z2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_40810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001106">
        <property type="protein sequence ID" value="CCD13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40810"/>
    <dbReference type="OrthoDB" id="1678836at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388787" evidence="5">
        <location>
            <begin position="21"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="62"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="39386" checksum="661D488FD36CAFD9" modified="2011-10-19" version="1">MMEGVKVMLVVGLMVTVIQADVKARKETNENGFGLLCDVMRLVRGLWNTATSDYEDFTAEDVRKLGQTINKIFFGEKGHESETSSLFLPDRFTEENPVRSDVCGYNRNNKVMQSAAQSMASAIFCLCTGITGVEDFCGLTNVGKGKWSNQDPEEDVKGVFKVVWGEKNDGGVMQKCDNTGSSENLEQERENLTAYIEKIEETLEKIGGVFAEKHTTCEGKTPCANVTRKPIWLENLKETEKITLAIIQSIKENSKSKQQTTESESAEITVPEPKSAPTHPATTLPATTQVLVKSPKQETRKALEEKTRPKPEPETEKPIEAPQKQKEDHLPVPENETSVSFLNSQKWLLATLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W866</accession>
    <name>F9W866_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001142">
        <property type="protein sequence ID" value="CCD13394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00360"/>
    <dbReference type="OrthoDB" id="792361at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40770" checksum="3E4EFC267AF41BE7" modified="2011-10-19" version="1" fragment="single">MREASSDKSKTSPAAMWSSGTTVKHSGGRPDVVAEKAAVFEELVTNLRRQVSYLEGRVSFLLRELSKKESSTVPEECREGAEEVGNGRSGDHSGGSTLRSTSEEDQVRPIVGDDLLTGVATPVAQPGEGHGEQLVPLHINARTMGLFIAMERLRAKHALDTDMLQCEKQAKDYLIEENSNLRLQIRELQRKMSEKEQLQQALNVYDAEEEQCEDTERVPHPGFTSPEKKCIKELLDDVICERDYYKVQTDRLRVSNQELSTRIGVLQEQLKAENTQMISMESSLLSVMQELHSIKQLHEKKFTVYERLDRSCAVVVKQMQEAVGVCESAQQRILQYSQDDAPTSTSLINFVSGELLKISAALDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W870</accession>
    <name>F9W870_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001142">
        <property type="protein sequence ID" value="CCD13398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00400"/>
    <dbReference type="OrthoDB" id="166083at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="205" mass="23557" checksum="FD210A3A4706959D" modified="2011-10-19" version="1">MMANAGDFDVVKDVEPAKCNKLGFPDVGTILRSLFQTYLRTVGWSTCDQWSSMKHYQGMQHWNGKLRLPCNNFWMELPVDKSKYGRRIALGRCVFRKGAEKAFYIHAFRVLFALRLAPWDIYTDSTLAQMLRTDSDINIERQRQWWDFVVQELIQPEGTEGNNVRSQSSSVREAEVLVSANSADLLSVPSPNPVMMQELAKRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8D7</accession>
    <name>F9W8D7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001164">
        <property type="protein sequence ID" value="CCD13469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42180"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="33844" checksum="5991CBAB0E586FC8" modified="2011-10-19" version="1">MHHHSVCQCGKLPPPTRARTCLSSCNCLIPLILPHAVAENTTQETMRFFSGAALSFFVLMLHAADVGNAFPAWGRSPICIEGLKLLKGVEDRFSEKLKTYALAINSTESLRAHCERLMEVVGPTADANDVRSRVKALKRFYVEFVKDQSVAAELREEVKRLVQDIKRECGSWIRFILGSWGIKNDVRQKLADGDRMKKELEKHVSKINNMWAAVNNTGCSVEYYDRLLEQYKRKHGPSNATGGQPAVQEPANANVSSESTESAGSGGSTTGGSNGTAGGNDVTGEGSGVPSGGESDGESNSDINSDSDSDSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8F1</accession>
    <name>F9W8F1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001165">
        <property type="protein sequence ID" value="CCD13483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42320"/>
    <dbReference type="OrthoDB" id="1095804at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019399">
        <property type="entry name" value="Parkin_co-regulated_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21207">
        <property type="entry name" value="PTHR21207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10274">
        <property type="entry name" value="ParcG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25965" checksum="93D2E721F71706EF" modified="2011-10-19" version="1" fragment="single">MSYEIRPLLKGTRRDPATRKYNKAAGKGPFGAFPPGFAPKKEDPTAPVEGPVAVQGVRFAYKGTIQRTGGTTTSMYKGRPHHEGSVAFTTNGAGDNRPPKAGAFKRRLIPPTEFRRYYDRGDLPLSVAHGNRPTIDWKVEVERLDYHHYLPIFFDGIRETEEPYMFLARQGCLDLLKRGGPKILPTIPQLIIPIKTALNTRHPEIICATLRILQQLIVSGDLIGEALVPYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8I8</accession>
    <name>F9W8I8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_42660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42660"/>
    <dbReference type="OMA" id="QHRAVIV"/>
    <dbReference type="OrthoDB" id="800324at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003603">
        <property type="entry name" value="U2A'_phosphoprotein32A_C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00446">
        <property type="entry name" value="LRRcap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRRcap" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="383" mass="43763" checksum="ABB0C37FF3CE6FE0" modified="2011-10-19" version="1">MGRITTELLRRRAEHNEGCLSNLKEIALHQQDIERIEVIGDACRELEILYLCNNYISRIEGLQHLKYLKYLNLAVNSITRIEGLDGCEALERLDLTLNFVADVSCVAALRANAFLDQLHLTGNPCTKVDGYRAYVIHTLPQLRELDGSEVMRTERLEARQVRDDVAATVDEEAVRVREAERIKAEMLARGVDPFPPRYNEKGERVYGHSPEERLQMLREKEEEEKRSKEQKRECEQSGQLGALRAELNQKPQRLTAEEEIAKYGRLLLRNEPKFPFALDEEAEDGEAVVVTVQVPRFLSTTLIDVQVEVDHIRVLVKEKLIQVPLSREVAASAVSVQRSSVTGELRIRVPYAPHVLQELAEAKRRRQRMLGKLQDDEVDDGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q4</accession>
    <name>F9W8Q4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1759</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001196">
        <property type="protein sequence ID" value="CCD13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43310"/>
    <dbReference type="OrthoDB" id="1729659at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18072" checksum="7C85018256611346" modified="2011-10-19" version="1">MKNVKGIRWREMVVTCANNSHCLPPAEALARRLCGVSLFSSGIGEGSVSVKAKGLRCLREFVLELTIGDVCCFCSLREGESAEPVVPLRVIFIISLPPYSSLSSFSTMWSFLQTIMLSCLNAYSCPFFVVVQLEQVHTVLPFWQSVGNMHTFSPLPPSHTQAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R5</accession>
    <name>F9W8R5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001206">
        <property type="protein sequence ID" value="CCD13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13511" checksum="50EFD288D88B407F" modified="2011-10-19" version="1">MANFFATPSVLLALFLFFYLFFFLSFPKYHLCRVRTSIRLGPPALFSSFPSSVRVFFRQVTGRDTADHKSGTGCLQKSAAFPSPHRALSPFLIGRFIFEFICSLPNCTCFGRIPAVDINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W971</accession>
    <name>F9W971_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1829</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001274">
        <property type="protein sequence ID" value="CCD13761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44680"/>
    <dbReference type="OMA" id="FGYSNCN"/>
    <dbReference type="OrthoDB" id="691939at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007921">
        <property type="entry name" value="CHAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05257">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50911">
        <property type="entry name" value="CHAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C51" evidence="2">
        <location>
            <begin position="109"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="30848" checksum="F28AED47021A6B64" modified="2011-10-19" version="1">MQRETEGRPKRSRASSERQDINDILQEDNCNNDYTTDLKDKWRSRVCSTASFAFAWAFGVLIVLFLVFIAFGVLYSGIRYRGGSNTCSNSFGAITGTHSGVFSYSNCGMDVNAIEHHNVTVEGRTQTTGVKWQCVEYARRYWVLRGTPKPAAFGSVEGAADIWDLDNVALLDGTTRPLLKFQNENATAAGSRPRAGDLLIYPRQPNGFPYGHVAVVAGVEERRLFVAEQNWDNQQWPGPYHNYSRELKLTCDASSTRCSVHEEGNIVVQGWVRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9W992</accession>
    <name>F9W992_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="8">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_44840</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
            <location evidence="8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="8"/>
    <dbReference type="EMBL" id="CAEQ01001283">
        <property type="protein sequence ID" value="CCD13783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44840"/>
    <dbReference type="OMA" id="MRWDKKS"/>
    <dbReference type="OrthoDB" id="268859at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF292">
        <property type="entry name" value="PTHR24031:SF292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="668"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD13783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="757" mass="85557" checksum="36F96CAE542E3472" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I2</accession>
    <name>F9W9I2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1866</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_45730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001315">
        <property type="protein sequence ID" value="CCD13884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45730"/>
    <dbReference type="OMA" id="IEEPLCG"/>
    <dbReference type="OrthoDB" id="964725at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="252"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="650" mass="72002" checksum="4547011530603209" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I3</accession>
    <name>F9W9I3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1867</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_45740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001316">
        <property type="protein sequence ID" value="CCD13885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45740"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="455"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="924"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1193" mass="132879" checksum="CC22330212FB99BD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD5</accession>
    <name>F9WAD5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1957</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001416">
        <property type="protein sequence ID" value="CCD14196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48440"/>
    <dbReference type="OrthoDB" id="1096872at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21910" checksum="1A2A48E6C10781F1" modified="2011-10-19" version="1" fragment="single">MKWAATSNGRYAAKVEKGENAWRREWSGFMSGVSMKDLRKGGGVALPKTSDLGAVGLGSDSGCTFSYLFASAADRKAERLAKKREEEEKRRSRSLKAQHTDDPLAHLSKHERSVLEARKRGLNVEGMTRKEIRQFLNLSTSKEQRAAEEQQQEEEFKPHKLMDEKLQWYQQGPHPIDVVAEKLVQRKAAKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG8</accession>
    <name>F9WAG8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001433">
        <property type="protein sequence ID" value="CCD14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48750"/>
    <dbReference type="OMA" id="KENIDAW"/>
    <dbReference type="OrthoDB" id="1655068at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="799" mass="91385" checksum="E41F405769554D0F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI6</accession>
    <name>F9WAI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_48970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001439">
        <property type="protein sequence ID" value="CCD14253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48970"/>
    <dbReference type="OrthoDB" id="142096at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="N-acetylTrfase_B_cplx_non-cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="PTHR22767:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="41431" checksum="B00AEB025FA9F586" modified="2011-10-19" version="1">MADLEACHQLDFKSIQHDTMSHIGYWPLVAGGAVDGLWQWINTAREYYGSLERDCSLLRSKVLTYMSWPAMRSVQEYECRQMNSVGRFIYMLHRIVGKFRECQTQRNLFDLMITEEKTLTYVFDALQDSRVDQLVDNTDWVAVRSMILGDIRSGKVLALSDTLAGMPSMKDRVRHARELVGSLMLLHDVALLEDYRLKMESVRNQGKKKKGGNSKILTESQSPSPPVLLCGEQTESLLVVPVLCPFVSALSDHIKTQGKGACMPHSDALELLLKDKFDITNVDAFLFPQAFILTAFLQVAPTSTFPVAAWARDLQAAVERVRGGLEKYNFVEACGSRERELREAKVSSINVILSDIYREAVGASRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAI7</accession>
    <name>F9WAI7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1978</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001439">
        <property type="protein sequence ID" value="CCD14254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48980"/>
    <dbReference type="OMA" id="CLVFIAC"/>
    <dbReference type="OrthoDB" id="1049789at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="662" mass="71690" checksum="DB3A993CCF590811" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ3</accession>
    <name>F9WAJ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49040"/>
    <dbReference type="OMA" id="VRAWYFA"/>
    <dbReference type="OrthoDB" id="1670380at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="368" mass="42775" checksum="13AB77124E40E236" modified="2011-10-19" version="1">MGVLDATSGEQPRLWSEAQAKVISDSWDPWEGDVVPGVEGKLVMAVLSSQKGWPYRFFDEEEIQMEKMDTLTGYNAACDAYIRKEDVRAWYFAKENINRWRMIFGYFCQFLLIGTSGIGKSSSTGSLLLYQLLRYPLEDLEVVAYFVDAGAYIFHREERRVVYHVEQAVALKEVNEMVSKDVKGYIIFDISGSSVNIEHLPYDWSIVLISSPKTSKFHEFTTQRYHPLPIYTNCYEDAELKAALVWERHWQLTKGQIKKENVNIANDWEVLKERIDMVGPLPRYVLADKATYEKRVTEVDGAMRSMRDDLGYYMDVFDNQSEWRKDDTTHKLMKLVYCQVKDKFECRNRVTSIYVQAELVKKTARGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAJ9</accession>
    <name>F9WAJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1981</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001442">
        <property type="protein sequence ID" value="CCD14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49110"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="18496" checksum="C2F5E0AFA9339030" modified="2011-10-19" version="1">MEKDVVEVLLQGIGSPEGINLHRFLEPAYPFIHSYVSRFSVRDFARNPWRCVGEAGGRENLWEHFPRLLWQFRVLALRLVDFAGPPESWGPRECEVWREFLKVDETDPEIMEGMVWVVCRMPPQTRGVLEAPYPIGHMGPIPMPALRNAWVISYTFYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAK3</accession>
    <name>F9WAK3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 198</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001443">
        <property type="protein sequence ID" value="CCD14273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05250"/>
    <dbReference type="OMA" id="DTMEKEY"/>
    <dbReference type="OrthoDB" id="1093348at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="35303" checksum="5610B689D1B37FA4" modified="2011-10-19" version="1">MRRTSSRWYKIPKNMGVAPRFDTWNEKYEPWQHMKRMGRLAGTGFYIPPEWYNHFRMFPPINHNFQQEKTLNPHNASEPTQDDTSTLSPERVALRDELARKSRLVASEGMRYYNIFWVRKPLDTMEKEYYDLKRKGVAHNDAIKKVLQSFYSELAIKKRVAAIQAEEAKLTGRFITMREATVVLGVLAKLHKEQLTPHQVGLLAKEQERTTETDGGLTATVSRVTAPHKETSDATAARAEALAEDETLSPDLLSSMMLEDVADGAVGSKYHVDVKETSVDSIRQLRERAEDHTGSPGWYTGASPTYDGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAS2</accession>
    <name>F9WAS2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001476">
        <property type="protein sequence ID" value="CCD14343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="17687" checksum="586FA6F8BB78CAAD" modified="2011-10-19" version="1">MKFPFFPNSVFSLNSIFSPNSIFSQNSPFCQIPFFAKFHFFAKFPFFAKFHFFAKFPFLPKFPFLPNSPFLPNFTFLPNSPFLPNFTFCQISLFAKFPFFAKFPFFAKFHFFAKFPFFAKFHFFAKFSFFAKFHFLPNFIFCPIPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV3</accession>
    <name>F9WAV3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_49940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001486">
        <property type="protein sequence ID" value="CCD14375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49940"/>
    <dbReference type="OMA" id="HPAGLPY"/>
    <dbReference type="OrthoDB" id="839325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="390"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="782" mass="84507" checksum="2F298DE001BD413F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB41</accession>
    <name>F9WB41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001527">
        <property type="protein sequence ID" value="CCD14472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50820"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="15053" checksum="1FE762731C61A0AD" modified="2011-10-19" version="1" fragment="single">MSGASMTTSGEREACLSRSQVSASPAVSPSLVQRGVERPMSGASMTTSGEREACLSRSQVSASPAVSPSLVQRGVERPMSGVSVVLPEECEACLSRSQVSASPAVSPSLVQRGVERPMSGVSVVLPEECEACLSRSQVSASPAVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB59</accession>
    <name>F9WB59_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001536">
        <property type="protein sequence ID" value="CCD14490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50990"/>
    <dbReference type="OrthoDB" id="1707753at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21304" checksum="6EF29A0A7477BFD8" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMERDVVEVLLDGVASADRINLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPESNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDTPLEAIDEEIWRRCRRPPPVPQYQPYKGVVLVEATPAIIQVPYSTMGYLVQIPFSPQSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB93</accession>
    <name>F9WB93_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2076</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001548">
        <property type="protein sequence ID" value="CCD14524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51320"/>
    <dbReference type="OMA" id="YSCRAIV"/>
    <dbReference type="OrthoDB" id="979502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="37273" checksum="4577D2F76881D3BF" modified="2011-10-19" version="1">MPATDEPAPYVKKEEPQRKTAVPTMKSYENEKFLRSTQGRLIRILCEFEEPASRLRRNHIRSTVLVFGSARSMTAEEHRAAVQKREAAIRSATRPEEREKAEKELQRLRSTEWMCEWMEKITELSKRIAEFSLKERDLINASFNRLPDYFRPNLSGLNKELSFEESTESFHDLIVTTGGGPGFMEAANKGAASVPDVMTMGMGISLPFEVGLNQYVTPGLAFQFHYFFTRKFWMMYSCRAVVIAPGGFGTMDEVFELLTLRQTQKIHKFPIVLFCVKFWKTVVNWEALVDYGTISKEEVDSLCFTDSVDEALAFIRNFFESTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBB7</accession>
    <name>F9WBB7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2088</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001561">
        <property type="protein sequence ID" value="CCD14548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51550"/>
    <dbReference type="OrthoDB" id="36763at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="294"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="443"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="790"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="869"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="981" mass="109861" checksum="F2EA39CD14C5B6F0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBN8</accession>
    <name>F9WBN8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001603">
        <property type="protein sequence ID" value="CCD14671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52670"/>
    <dbReference type="OMA" id="TINGDCI"/>
    <dbReference type="OrthoDB" id="1104994at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="762" mass="82817" checksum="7E15CDC8DCF15A2F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT9</accession>
    <name>F9WBT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="790966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="14690" checksum="ADE70BD69F956400" modified="2011-10-19" version="1">MYGAKYHNIPFDLSELSDHTLVVHMRNLPRSRYTNWRLQSGPIWRPLVGWLHCSETRQAHREAQQRFKNRGGKLEITQLHLHVPKDEHRFIVVCTNFAPVAQTKQIKRIAAARVWSLESQSRSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG2</accession>
    <name>F9WCG2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2229</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_55230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001719">
        <property type="protein sequence ID" value="CCD14955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55230"/>
    <dbReference type="OMA" id="YVKLAFK"/>
    <dbReference type="OrthoDB" id="954459at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="295" mass="32168" checksum="CD26989BD4A18CCF" modified="2011-10-19" version="1" fragment="single">MASATELKQRGNEAYSAKRFEEALKLYEEGLTMDGENIDLLNNAAAANFALEKYDAAITCARRSLGVRDNFKAHKRLGEVFWKKGEIAAAAAEYQKALELEPADSSTRTSLQQLKEQLQRGQQQQHREAGPVRGVVPHSVTSGKVGLLADSIALGLSCATLVCILLALPHAQAAWSCLLLFSVVRQCIIAHHMGFIVPQRSVIKTWFDNRSTLDLILYAVALVSGVSAQLPLVFAQGIYSALSFSSNFSELQAIAPVLYQKCLPYVQQISSRTPSLIMNAATSEAVMFLTVMFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCH0</accession>
    <name>F9WCH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 2232</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_55310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001723">
        <property type="protein sequence ID" value="CCD14963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55310"/>
    <dbReference type="OMA" id="PARASIC"/>
    <dbReference type="OrthoDB" id="1065966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="40S_S4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="KOW_RPS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_S4e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_S4e_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="7">
        <location>
            <begin position="74"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD14963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="307" mass="34377" checksum="1476AD769EC7F894" modified="2011-10-19" version="1">MFLTPMITHAKILLFTVVTLFYSLMNRWGTRLIVMAKKHLKRLYAPKDWMLSKLTGVFAPRPRAGPHKLRECLSLLIIIRNRLKYALNAHEAQMILRQGLVCVDGKPRKDGKYPAGFMDVVEIPKTGDRFRILYDVKGRFVLVRVSEAEAGMKMMKVVNVYTGTGRIPVAVTHDGHRIRYPDPRTGRGDTLLYDVKAKKVTDLIKIGSGKVVMVTGGANRGRIGEIVSIERHPGAFDIARLKDAAGHEFATRASNIFVIGKDMSSVPVTLPKQLGLRKNVIVEREEKLIAAEMHKTIKATGKRKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ0</accession>
    <name>F9WCQ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56110"/>
    <dbReference type="OrthoDB" id="1715959at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18419" checksum="6DD29A77A5E69BDC" modified="2011-10-19" version="1">MVSVITHLQILWNTLRAEKGTLSLKPSPTRFTRLKKRIKSSRTGTIPYLPPLFSNPLDLPFFCLYGRRKRKKKAQYLEITIMVIHPSPSLAPPWRKRAMEGKDLFSSMSDGKDESSIGSDTIFGGSLHQYADFFSLSIKFGVLWLGRFSGICISISGTPPPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCR0</accession>
    <name>F9WCR0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56220"/>
    <dbReference type="OrthoDB" id="1668502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390155" evidence="2">
        <location>
            <begin position="28"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="394" mass="43915" checksum="70752ECE0D29A964" modified="2011-10-19" version="1">MKEPWRMGRGVWAMVVAVTMFMRGVRGGVSDYQPGWSFNGAEHDALCDVFQASLDLWNASRKSNLKLGGGLENALGQAIFGSTSGGNIEGLKDTLPQEYKNPERRQYRCGSCNHHKETYPGKSIPHDLMCLCTPGKYGEPFYGYWFFQLVFEDTGFKLCGKERKDMVNNHHDGWYEDEKKREARGLEKPWKTVVMGCVNSWKKNGGAVNQTLEEKLKTLIEAMTNFGTELFKDGNRWDKLGGMKEHHTESDGRDEKSIHVRYRLCQKKKKPWWRKLQEVLGKPQIQLLVDPSAVTHAKEPGQDLEEGEEILEEPGERNMDSGGGTSSQAGSSTQGGSDGNATQTQGFNNGSNSTVGMTNTSASENSTSTRFGMLRSGTPITPPTSRFLSAVFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD47</accession>
    <name>F9WD47_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001820">
        <property type="protein sequence ID" value="CCD15198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57430"/>
    <dbReference type="OrthoDB" id="1721657at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19178" checksum="5240DC2D9F4D3D87" modified="2011-10-19" version="1">MHSGKVHHERRTAEGSFSHDGRGRLSRASWVQSSGYQPRKAPPYSKRFQEALLFPHLCPTSTVSQNMCMAQPDPRRSSGGGVSHGRGRAARSVPAGRTDLHYPRPVWTNSLKILESTRRIREDGGKFHRPFHPSYHAMKAPVFHDLETWRSMASRRWTHGLTACVGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD94</accession>
    <name>F9WD94_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001839">
        <property type="protein sequence ID" value="CCD15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57870"/>
    <dbReference type="OrthoDB" id="1671475at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390200" evidence="5">
        <location>
            <begin position="27"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="370" mass="40872" checksum="A6E75B7535B04678" modified="2011-10-19" version="1">MERMLRLTLKWMMMAVAVIFVSGSSSISIASVGKEHNKEEHARLCNLLMAAVNKWEEVKTRESTDPLKRALGKTLFGNENGGEMGDLKGGLPKDYEKVEGELSLRLTWCGLPQESATGKKKPRWPGHSAPHDLLCLCTTGQDGYPFNEVGSDSGTATMLCGKPKEALGGGSDGWDSKHRGGGAAHGKDQMTATWVNVTQKCLGGNGERKDLNEALGDLFWKLGKKDPRGGHTERYQLGEGQSGDDYPCSGNEKICVMYYNSTEHKHPMPWWTELQDAIKKDDELHPKKKSEEKRSNKENAQKQRKTQNQENSQPQQEPRTAALRSTTPSTEEAEQANPENISSPLATLEDTTGTPIISPCIWFLDALFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD96</accession>
    <name>F9WD96_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2338</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001840">
        <property type="protein sequence ID" value="CCD15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57890"/>
    <dbReference type="OMA" id="SHKGGYL"/>
    <dbReference type="OrthoDB" id="1021764at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="255" mass="27904" checksum="EAD38185D5BC301A" modified="2011-10-19" version="1">MSRGVSKNGNIPNVQMRSSRGGYLCCPFTLNPSFSGAACGYTAPNVGSKRNRYGSDCGVDEDDSEGFTRPWVRAGVGARSLGAKERRQQQDEARRIYGPGSMSREEADESGATLAESAGTTAFGLTRWEQSALQKVLPRAEHRKGGRMHTSNKHSRASDEDEEKGESSAKLQKAFCQREVPCAARRSRAEPSSLSPHRADQRTGNKDVGCDGLRVSVRNDEILSKGTKPMNNLKMLDRAREAILSGNRRGGRNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDD8</accession>
    <name>F9WDD8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001861">
        <property type="protein sequence ID" value="CCD15291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58220"/>
    <dbReference type="OrthoDB" id="1268218at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="765"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="841" mass="91780" checksum="873E3B9829A9AFC2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDR6</accession>
    <name>F9WDR6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001901">
        <property type="protein sequence ID" value="CCD15420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59420"/>
    <dbReference type="OMA" id="MTEVFLH"/>
    <dbReference type="OrthoDB" id="1179072at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="323" mass="35861" checksum="DCC0D1D5FE91ACEB" modified="2011-10-19" version="1">MSGETVRNILYRQLTCPDFAMYCVEHAADPSLKFLFSREDSSERQLYRALLQKVNMGSNRSYVKSVGGKNCCSGRQSGASARVWALWYLLAERFAGAGSSAAVRGPHVPHTFRSVEDLAEFVALVDSAVSDNNGHEPLVRYMRGRLPMTEVFLHIIYYICEDYITQVRRSTSKSFIQLCISKGSKKSIGYSSELSGGKYAKKESRFATASGQNACSTTNGDYVALPDDYVDEETLRKGGTLLYLLNVLLSQHAKVDGGLRYKAVFEYYLLCMVELLAKCAAPGSSVLTFVRETVEAWSQRCVFSGDALQRMRTAVVVGRHAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE23</accession>
    <name>F9WE23_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001942">
        <property type="protein sequence ID" value="CCD15529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60350"/>
    <dbReference type="OrthoDB" id="1718953at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18475" checksum="12777CE1662E2806" modified="2011-10-19" version="1">MRSRPSTDSFVEYVCSTHSENEAGIPYLVVGQNLYAQLWVLSHNHFGQPPPAQSFQLLQLRSTVPHTFYGVFYVYARGASRRVKDADTRTRISTLIAPHACIGPSPHSSPLIVAVRRSTINCTAKTVMVRTRLQPNLQSISFQRENAAAMNRIFASPAYEFFSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE28</accession>
    <name>F9WE28_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_06310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06310"/>
    <dbReference type="OMA" id="TPYGMCS"/>
    <dbReference type="OrthoDB" id="871292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3">
        <location>
            <begin position="454"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="699" mass="76468" checksum="642ACA1C5207A7DD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE79</accession>
    <name>F9WE79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_60710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001959">
        <property type="protein sequence ID" value="CCD15585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60710"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17958" checksum="D68A8313D8126B86" modified="2011-10-19" version="1">MREKHPDHDESLRPQPRAKPKRKAVRSEAQAQDEGSRSTELAGGGDGEGERPRKRPRMGRHKESEEGRNHVCHWSSSAYKQRYSLVWHTRTHHDHATTGKRKIRDGKVAVTPLLQQSLQCPYCPMKCALKMHLTIHLQAKHGQPKKRGRTQPSEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ6</accession>
    <name>F9WEZ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002083">
        <property type="protein sequence ID" value="CCD15862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08590"/>
    <dbReference type="OrthoDB" id="1704556at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="287" mass="33736" checksum="935DD3362D4EC8AE" modified="2011-10-19" version="1" fragment="single">MEAKKKVKEAEEKLEQAREVEQKAEEEREKVLASLLYRNGLWEQAMKEFGRIEKEQVAKPDVERLRRELETADRRRSDAQEHRRVRETKLETARLELANWNPEFERVTQASAEARQLQAWLLAVSQSEVVERELAKARGRQADCELRQILAEGLHHLAAATQGGDAAERELEEALEEWEEARDELKRTEEKLEWAIEAWVRAIQQWVEGPKEACEEAKENLEKAEEELERASEAWKATAIEKWMRANEKVRWSRRAWDRPWAEAREEWKGAEPRLYGARDLSGEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF42</accession>
    <name>F9WF42_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 348</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002102">
        <property type="protein sequence ID" value="CCD15910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09020"/>
    <dbReference type="OrthoDB" id="1699156at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="21192" checksum="09F3885FA94C49FE" modified="2011-10-19" version="1">MRGALKSVDDGNGRCGGSFSRWMRPTPSLWTGWYGGPVECHRSPVECSKRHTRLVTWGRFPCLLQKSRVLGHPHRSIVSPSSFLPPCAVWVCLPRNRNDSFSPVLCPLVFFGGKGNKEKIVSENHNGDGHLSFDGSSVEEESFCVETESCWSDGGGNNGSKSPFGMNLRKYADFLENMFPLPMNTHLGKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF50</accession>
    <name>F9WF50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002104">
        <property type="protein sequence ID" value="CCD15918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="15980" checksum="EBD732BD6735ECFC" modified="2011-10-19" version="1">MRPIKGASANLEMKGKKQGKDQRTCPQSNTFQPQLSSLTRTGGCIKAAAAFFACAPHLSCAPWPHVPKHVVLLEVLQRLSEPRWCPLHRATPPPQQTPSLHRSHRPNASALPPDLPLLKVTAARATGGVTTKKKENGKKRWKESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFD3</accession>
    <name>F9WFD3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 372</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002128">
        <property type="protein sequence ID" value="CCD16001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09730"/>
    <dbReference type="OMA" id="CIEREKC"/>
    <dbReference type="OrthoDB" id="1152256at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="744" mass="81753" checksum="38BEB887286153C4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG3</accession>
    <name>F9WFG3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 383</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002141">
        <property type="protein sequence ID" value="CCD16031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10010"/>
    <dbReference type="OMA" id="GNYEEMQ"/>
    <dbReference type="OrthoDB" id="1497731at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28214" checksum="A3770BC2801FA07F" modified="2011-10-19" version="1">MPSDVAELQHTDEEYVRQRLSLEFPSVDDEVLTEMAFLVGRRRHTMDEAVHMLHLVEKSRSGDAASAKGSDEAKVSDRHVSGPPVLVSPNLVPSSAKLRGAAAIDVLGDEMSEALRVRSTCRNGGAGAGASSAGAEQRLPVGVENPRTVKLFHTTMTGDRRIRAHCRQADTLLYLKRIRYEPVNVADSPLMQQRLRELYRTSTGRKTPPPLPALFVGSNYVGNYEEMQDMEDDGILMDTLKRLGYQHEATSNGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ1</accession>
    <name>F9WFQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 415</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002176">
        <property type="protein sequence ID" value="CCD16128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10790"/>
    <dbReference type="OrthoDB" id="1574322at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="22213" checksum="18B0F2818681CECB" modified="2011-10-19" version="1">MLAITRLRALPKDTFKGVDLRRPTAQTEDVECPRRKHLLFDFPSLLQAYEQNIIDHLTDKLNCNKILIAELVLHQLDVENKECSRRDRSSGEISTESIRLRDFIKFLLERKSEEYMMFQRKGSQEDVSFIERHKLIGKNCDSKLRLLSYALYIKGEGHPVIFITSDDDLFNEARKNDIETRTVESLKAVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX0</accession>
    <name>F9WFX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002192">
        <property type="protein sequence ID" value="CCD16200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11490"/>
    <dbReference type="OMA" id="DACEAHC"/>
    <dbReference type="OrthoDB" id="268631at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="685" mass="78534" checksum="FEF039AA7C532096" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFY7</accession>
    <name>F9WFY7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 439</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_11650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002202">
        <property type="protein sequence ID" value="CCD16217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11650"/>
    <dbReference type="OMA" id="MCANAPV"/>
    <dbReference type="OrthoDB" id="1525207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="515" mass="55172" checksum="CEAC2A06E430ED8F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG51</accession>
    <name>F9WG51_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 465</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002231">
        <property type="protein sequence ID" value="CCD16285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12290"/>
    <dbReference type="OrthoDB" id="1421036at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1544" mass="170469" checksum="32F099CB828B3BC7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGI5</accession>
    <name>F9WGI5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 505</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002276">
        <property type="protein sequence ID" value="CCD16421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13420"/>
    <dbReference type="OrthoDB" id="1721964at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="16933" checksum="A5660CFFCC4D120B" modified="2011-10-19" version="1">MIASNDEDARRASHSDTMPPPDTSYGGCEVYMWGVTLGFGSDHIWTTVEVTSMPGIGRIVPCKSKECSTRGEKLIGKASLGSVKKTWSEGTTSPSSELTHSFGLRRSPFTRLRQKRSFEVRRGSSRVGQGAYRFGPRDGKAPKCEAAWRIRMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH18</accession>
    <name>F9WH18_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_15170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UBR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01002362">
        <property type="protein sequence ID" value="CCD16607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15170"/>
    <dbReference type="OMA" id="THEDESH"/>
    <dbReference type="OrthoDB" id="12770at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="PTHR21497"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PRT6_C" evidence="2">
        <location>
            <begin position="1453"/>
            <end position="1531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1580" mass="177599" checksum="1ECC3B852FF2B87C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH47</accession>
    <name>F9WH47_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 593</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002373">
        <property type="protein sequence ID" value="CCD16636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15450"/>
    <dbReference type="OMA" id="ATHIRME"/>
    <dbReference type="OrthoDB" id="1654830at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="810" mass="92147" checksum="CA3AA4AA8F3073DA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH60</accession>
    <name>F9WH60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 598</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002379">
        <property type="protein sequence ID" value="CCD16649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="23087at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="991" mass="112710" checksum="099EFE66220093F7" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH72</accession>
    <name>F9WH72_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002388">
        <property type="protein sequence ID" value="CCD16661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15680"/>
    <dbReference type="OrthoDB" id="416865at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="19479" checksum="7F681C65C7FC3B55" modified="2011-10-19" version="1">MGRENERLRAEVELLQGHMKNLMEELGRKDEEMARLRTEADLTDQRIKEIRDVVRAEDDAKLQVLDAEWQRKLRQFEIKHVEEVGAMQHEIEKVTIELQAVKNAAALEQRNIEQKHNAELTCINERVLVALATKDNTLRAQTEQISVLQEAIRLRDEQISRHRELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH86</accession>
    <name>F9WH86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002396">
        <property type="protein sequence ID" value="CCD16675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="13313" checksum="55E40AE4D7D52449" modified="2011-10-19" version="1">MKPLVFALPTLYYGQHVQASTSSFCFLVARLLVASHTVTEGLSFVSFISSLIKLINGVSTVIHCVHSMRHHLFFFVRAFNLPHLSFDKLQPLNHPFLYVRKFLLSRSLCKIVCIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI7</accession>
    <name>F9WHI7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 654</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002441">
        <property type="protein sequence ID" value="CCD16780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16810"/>
    <dbReference type="OrthoDB" id="1707785at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24082" checksum="39FAEBEA2D3A3302" modified="2011-10-19" version="1">MIATLGNGSERRNGKGLQHSCRILRVAEWESRGESPTSSARARRLFANWKACLRAAGGGEAGRHGEGSRGFRDQTGDTHNRARECQACHGKGRKFMFQLRRNCCVRLNGVCVQAKNSLIHSICGVPVVEIAVAKDTPSALRNVSCGGGGGLGHPRSSKGCGPNARGLFACRVCKWLLKACASRERHRIGRHGGATLPEDPPCMAALDAAEDAAAERRGGEERVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHL3</accession>
    <name>F9WHL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
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                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="293"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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            <taxon>Nannomonas</taxon>
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    </organism>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
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                <person name="Gilderthorp R."/>
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                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
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                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="EMBL" id="CCD16925.1"/>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
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            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
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    <comment type="caution">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000000702">
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD16960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18289" checksum="DD9E48B2E1BA3189" modified="2011-10-19" version="1">MEEWISGQPGELGKSTGMGYSLFAESEEEQWRRLKEEAMIDSDDEEDLAERENIPVTEPKKRRQRNPTKTSTAIKNGHSQQQQKLTHAISSYDMEKLLKQYRDISAEEEGVGVDITRFLQDDGNDCDKDEEYVVTADELLSSLTTGKSTNIQRGVDSADSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI60</accession>
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 73</fullName>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002531">
        <property type="protein sequence ID" value="CCD17005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02020"/>
    <dbReference type="OrthoDB" id="1666453at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="543" mass="57684" checksum="80173E5D7F7AF7B5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI68</accession>
    <name>F9WI68_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 736</fullName>
        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18750</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002533">
        <property type="protein sequence ID" value="CCD17013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18750"/>
    <dbReference type="OMA" id="PRENEAM"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="761" mass="85823" checksum="59CBF8A49E9C030C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIB1</accession>
    <name>F9WIB1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 760</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002559">
        <property type="protein sequence ID" value="CCD17057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19140"/>
    <dbReference type="OMA" id="PPTHMLL"/>
    <dbReference type="OrthoDB" id="624347at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="333" mass="38230" checksum="F25A288DCE47E8AF" modified="2011-10-19" version="1">MLRRCSPHNGWILSLRYFSHVLPDAQLSGVCKKKHIYRSQQWYPQSNELMGAVYSIMYEVLLNILALPSSEFDTHKEMVCLRLLDTIMSFCRGRIPAHMLLPNQMDRLLPRSLSSLEDMPNIKTRLRIGLRLVRCVIEMCPDTSGVSVTLHSKEHLLTLTVMLHELQKLLCRVAEHRCHLMETGRDYKPSQSEWDLQVGAKLLSGQKKLEISATETGLLWRTSLELLLRQCQWCGVSTMTSGTLKLVYQTCASAGKQWKAALLATEYLLREQRQQQQVVAQNPVVPDHCSRFCSLFGWEKALGFWCTHFPQRTLGEVVAYPKGAEYCMNFIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE9</accession>
    <name>F9WIE9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 779</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002580">
        <property type="protein sequence ID" value="CCD17096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19480"/>
    <dbReference type="OrthoDB" id="1718957at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18806" checksum="57533BAE21D28F2A" modified="2011-10-19" version="1">MEGRGVRRTRDEMEGEADAADAAASHETLVGARTTWTLDSPVEEVLLCNYGGLSDMSLHDFLMEHFGETFGSPNVSMSVFVDNPSFFLRDESLRTAITCSQPYREFVREYRKEYTAMNEGVNSCRNMGIFSLRQWSTAAAADKVGKILSLCDGQAEPRTSSVPDVTRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIL0</accession>
    <name>F9WIL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 809</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002613">
        <property type="protein sequence ID" value="CCD17158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20030"/>
    <dbReference type="OMA" id="QSCCACM"/>
    <dbReference type="OrthoDB" id="1209592at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="279" mass="30786" checksum="BA3C00322D07A2CC" modified="2011-10-19" version="1">MDLLCEEINAPPEYIGHVVGERGATIARLQSETGATITILDGCKVHITAEDPTQLRAATECVRQIISDAINPDYEGPDGRRLRKEAAQLASKRAQLFNEATRQREEGNMQQMSALLEQGKQVGEQMKLTNREAAAAIAWYNNEGKGRERNYFDMHGLRVDEALEMLRARVEALRVALKGASGELRVITGVGRHSGPEGAKLRRAAVEFFRAEGLVFEEVSAAEIRATVTAAGPPVGHHQPQREADQPVENVEKKMTGSLGEHQKPQLKKVEETKFCCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIL7</accession>
    <name>F9WIL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002616">
        <property type="protein sequence ID" value="CCD17165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20100"/>
    <dbReference type="OMA" id="FFAMYGD"/>
    <dbReference type="OrthoDB" id="351712at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1939"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1376"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1440"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1945"/>
            <end position="1988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1988" mass="218423" checksum="0BFDF02A35391A08" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU1</accession>
    <name>F9WIU1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 834</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_20750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002640">
        <property type="protein sequence ID" value="CCD17239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FTIEIRE"/>
    <dbReference type="OrthoDB" id="318396at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="53"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="37647" checksum="DFF648DF374CDE00" modified="2011-10-19" version="1" fragment="single">MVPLLLLLTAFGVVLLTCIIVGICLSGKKGNEDDAPLLPKKSDARHLSVEKRVCVLYGTQTGTAEMFAKTLTREGLRLGFPLKLIAVENYRPSDIRREKRVIIVCATYGDGEPTDNMLAFHEWLMDGSRVAGEELKQLKYAVFGLGDRQYLNFCREGVTVDRRLSELGARRIYPLGRGDSSGNIEEEFDRWRRGLWPVLSDELAVDLKSVADEPVVPECLLKMWDASEEAPLPFPKLASMLEPTQRLPSWVPVKANEELLRVTDGRSTRLVELDISDTVISYQAGDHLGVLPSNTDEVVDAYLRALSVSEEDSRQVISLQNKATGKNVFPCRVSVRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ54</accession>
    <name>F9WJ54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_21830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002684">
        <property type="protein sequence ID" value="CCD17357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21830"/>
    <dbReference type="OrthoDB" id="1667818at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390469" evidence="5">
        <location>
            <begin position="17"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="82"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="358"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="43828" checksum="0786B7E15EC8CCB0" modified="2011-10-19" version="1">MMKLFMVMMLVMGGWVREWRVMATAEVSVKEGENREPFALLCRIYNVAQHPPIKPVDTKEYKKMVDDIDALNAAANGKERVNTQSEETKSAQTQLIGISRDAHKLLDGIKKVNPEGQVEKARNTFHQVIFGKNGKEGHLSHGTLEVEQNRITACGGKEKEGKSAGKNLVVDFFCLCAQHTEASDGVERVCGVSVGSGRDSGWGGTLVSADTMWGEIKDGCKNGAPQGVTSTQDGYSLYDYFLAKVKAGGNVKVIDSETVKKHCMLGTAVSKTGDTNFNCNGKKTFHSRHSSGSGVGVCIFYGNHHLEENIAWLSKFKSGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADSQLEEVDMEEPIAAQHPNPDENENADSSTQSRRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ82</accession>
    <name>F9WJ82_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002695">
        <property type="protein sequence ID" value="CCD17386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="16786" checksum="0DBFB4D1AB6297EF" modified="2011-10-19" version="1">MRETIPTRSPPPLPAPTQREEPLQETHVPEVEVEKAPTERFSPWTMQPHVGAILLQGIQNPELLRLYEFLRLLCLVFKQDYSGLTVGDFLRDPERRIPDTLPWEEVMKKLHRLMTRLRIHILATLRYLAWRNIRTLEEWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ92</accession>
    <name>F9WJ92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002700">
        <property type="protein sequence ID" value="CCD17396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15498" checksum="899B39BECC98FC7F" modified="2011-10-19" version="1">MRINVVVQLQRSLACLCLRCLASSFCVGFLCSLFRFMFAIWTIIRQCIFVDVVMAQLIGQTCIIGHRLIIYEQHVQAVEVMGTRSSMVESLPDDRWQRYIQYNLCAAQFNGICGPLMGIHKFLFRRRGTRTGIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ95</accession>
    <name>F9WJ95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 889</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002702">
        <property type="protein sequence ID" value="CCD17399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22200"/>
    <dbReference type="OrthoDB" id="1709035at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20511" checksum="3FBF04F1938D7A3A" modified="2011-10-19" version="1">MAAGFCPGTPPRFTFQFPSHVVCVVEREYRSNAGSIHRGKALPLEASMVNQPRGRACGVVATIHSNRTKLARTVPATPQLLLFTRVILILMGTPTPPTTFPTGSFVAVIRSAFLCRSHHSVPCGLNRRTLPLGADICGCRRLSTPTRWATSPVTGWFIFLDAFEIASLVGLRRGSWSPTVRAVDQVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA6</accession>
    <name>F9WJA6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002704">
        <property type="protein sequence ID" value="CCD17410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22310"/>
    <dbReference type="OrthoDB" id="1669528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390484" evidence="5">
        <location>
            <begin position="29"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="318"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45769" checksum="78911E934C56AAEB" modified="2011-10-19" version="1" fragment="single">MWMREPRMIGRGTCMIMVLAMVVNLVHAYPPGTVFNDGEYNALCGVFHASLDLWNATHTAGKVPSNGLKAALGQALFGKSSGGSLESLKDELPKEYRDPGQRKYRCGYCEHREETYAGKSITHDLMCLCTPGKDAEPFYGYYWWFGYYYKENGFKLCGRLREEMGVDLSHGWYESGRKRGTNGLKESWRTVIMGCFNSWKNSTKKGSDTMEEKLKTLTETMKHLETKFLKKVGGRHKLGEFNENNEADGSSEKHIHVRYGTCTRGRAPWWKKLQDELKKPQDQLLLEPTVAAQEAISTEGQQEGEEEEVLMKVEDFSPQEEDTLGGSTTKSPKQDINSTQTINQSNDNSTVSMLNTSETGNSTYPRLEYLRSNTPKTPPCSGIIRAYSSSKIPFRKTYKDPFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJC5</accession>
    <name>F9WJC5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 896</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002710">
        <property type="protein sequence ID" value="CCD17429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22480"/>
    <dbReference type="OrthoDB" id="1719814at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17070" checksum="5DED1E79867B22BF" modified="2011-10-19" version="1">MGNCLCCGDKGRAHESDTEGTNANELATHNRIEVSHKRRESVAWNQEDDFATTGDSPNSVFNDVSLSCSPRNNGLIATAPPDEGSFASPTEDLLPPSASEEDPHADSTPNHALHVAPLDEDAPCTTPVIEERLRDISQEADEYAVPHNRECTECPDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJF5</accession>
    <name>F9WJF5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16457" checksum="6ED3F8CB7DEDDEC3" modified="2011-10-19" version="1">MENDTLNSPRTSPVTMETTVEAILERARDDWGAVPAATFFSIYPVHRYVVVPNSPLTMQQYWKDWRRFVPDSVRRKCFQYRLRLMSALMRRHLDQDMARLRAAKVVTLEEWQREGGRVEIGPMARALLTEALLHAVLPSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH8</accession>
    <name>F9WJH8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_23010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002728">
        <property type="protein sequence ID" value="CCD17483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23010"/>
    <dbReference type="OMA" id="DINIRVY"/>
    <dbReference type="OrthoDB" id="558573at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="687"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="737"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="781"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="3">
        <location>
            <begin position="559"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="835" mass="92748" checksum="A36B4B50A10FDA08" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D9</accession>
    <name>F9W3D9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000398">
        <property type="protein sequence ID" value="CCD11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="14059" checksum="F088F1CEB9CE8156" modified="2011-10-19" version="1">MQPHSLLPSFHIANFAILHASVKKKKPSLREVCYAHTHTYTCIYVYTHLYYRVILFLPSFLFFGAAVFICCAFPRARWSTVFSGGGKETKIVYFRSTKKENIFCRTTVPFTSTQKASSELLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3E0</accession>
    <name>F9W3E0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AP-3 complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_26160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000398">
        <property type="protein sequence ID" value="CCD11651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26160"/>
    <dbReference type="OMA" id="IGRCAQS"/>
    <dbReference type="OrthoDB" id="323029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="PTHR11134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134:SF1">
        <property type="entry name" value="PTHR11134:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Adaptin_N" evidence="7">
        <location>
            <begin position="49"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="710"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="726"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="884"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="907" mass="98501" checksum="F4AA9662E1ED0AE9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I8</accession>
    <name>F9W3I8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_26600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000416">
        <property type="protein sequence ID" value="CCD11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26600"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394660" evidence="5">
        <location>
            <begin position="21"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38257" checksum="362360F8107DE3A3" modified="2011-10-19" version="1">MMFLVIVGMMMMALSGGSLGTGTSEHHNHEEHATLCGLLGAAATLYNSGRAGEKLRKALGQVIFGKEDGGSLADLKRGFPEEYGKDGGRHNSCGECRHNNHDHYPGKSIPHDLLCLCTMGENGAPFNSGGHYSLCGVTGDRWGCKAKERNTYYAGDGQHWDCTNQQNGQSTWHHEKRKTAWQQVVQTCLKRKINLTLKDALDTFKGKKTGGHIINWNRNPSSCGGTSPDTICVGSSGWCGKETDNSYPQWLEVLEELTQEDFKLLERPTVKRRRRRQARNSTIQEGPDAEDDAEEEEEEFTTSTEGTSTTASLDKSRNHLLSLLSKHDGTSLPPPHSWLLSAVFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3K6</accession>
    <name>F9W3K6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1069</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_26780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000429">
        <property type="protein sequence ID" value="CCD11725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26780"/>
    <dbReference type="OMA" id="CSHPQGN"/>
    <dbReference type="OrthoDB" id="1264766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39563" checksum="36493F4A51977367" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYRDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGKAPEAVDWRKKGAVTPVKDQGKCDSSWAFTVIGNIEGQWKIAGHELTSLSEQMLVSCDTNDLGCRAGFMDTAFKWIVSPNDGNVFTEQSYPYASGGGNVPACNKSGKVVGANIDDHVHILDNENAIAEWLAKNGPVAIAVDATSFQRYTGGVLTSCISKEVNSAALLVGYDDTSKPPYWIIKNSWGKGWGEEGYIRIEKGTNQCRMKDYVSSAVVSGPPPPPPTPTFTQELCEGAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U4</accession>
    <name>F9W3U4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_27620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000477">
        <property type="protein sequence ID" value="CCD11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27620"/>
    <dbReference type="OrthoDB" id="1670742at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389762" evidence="5">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="48"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38948" checksum="CB36F678F219ED0A" modified="2011-10-19" version="1">MILIKCWKIVMVGIFVAGLSNGTNHNENAHRLLCKVLREAVGAFKSDRGSEALKKVLKKTIFGDENGGNLDTLKGNLPGYYNDQQGRSRANVCGQAPDGEYRTGKNLPWPGHSAPHDLVCLCTPGDKMWPFNNGIDTEKLCGQDKAALAEGKNEGWNSSRAGEEVKEQIKATWANVTKTCLESDGNGNDLNEALKDFIGKLEKKPGTKYQERYQLGEGESHDYPCGGNGKVCVMYHNSTDNIKHKHPMPWWTELQKAIKVEEEKKEKKRREEEKFKKEEAQNHQKAQKQDESQPQHVPRVTAVKSAAPDTNEAHQGKTENISFPLATIEDVSGTPILPPCSWLLSAFILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y9</accession>
    <name>F9W3Y9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1128</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000495">
        <property type="protein sequence ID" value="CCD11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28060"/>
    <dbReference type="OrthoDB" id="799520at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34931" checksum="01CF27688525046E" modified="2011-10-19" version="1">MLSGRTPFYSSVNSEIYDNVLKAELDFSDPCFTPEAAALIERLLQSHPSQRLDDAEAIKAHPYFASVDWAALEAKKVPAPIQLDLTMSDVRYIKWKFTSEWATIPKPSDVTRDTVDMLISRFSNFAHVSDEAPPTSASGQAANGEEQREQDDTAATTTTPRGSRDVVGLWSIASVEMRTMDGKVVYPWGSKVRGVLAYFPDGQVSLQIAAQMRPCLRHHLAERATREELIEVCNSYMACFGTYETDAGANTIAHRLHGSLGPNLTNSTQKYTYKLEGSDKHGVEKLKLYSSFNELPGEHMAAQTILTWKRVSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W428</accession>
    <name>F9W428_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000507">
        <property type="protein sequence ID" value="CCD11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28470"/>
    <dbReference type="OMA" id="HDMEVSA"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17452" checksum="C40E695ED5D81C21" modified="2011-10-19" version="1">MGSLRTTSLLCAKVLIGVQSRRPFSTGLDCITRWSAEHDMEVSAEKTEYTLFAARETNLLSLKVAETVLKEVRTPKLLGLTMQPHKGLSKHVQGVKAAADERPLQLRAVASPEWGPEREKLRAFYRALVQAKVCYGMASLWFYTSLSDRERLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W434</accession>
    <name>F9W434_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_28530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000509">
        <property type="protein sequence ID" value="CCD11917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28530"/>
    <dbReference type="OMA" id="FNVGFQY"/>
    <dbReference type="OrthoDB" id="734703at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038670">
        <property type="entry name" value="HslJ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="SSF101601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="38"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="261"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1935" evidence="3">
        <location>
            <begin position="372"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="475" mass="51517" checksum="D738FF2872397A04" modified="2011-10-19" version="1">MLLVLVGWTLVAMNCLTVLFLFLGRLLSPTMDGAMLCGTYKVINIDGNACSEEAFVAVETTNDGVKVEAMVGNTLCGKGVVDGGRITANLASTMKLVEDRKMRIEDLLICGFRSGFAYEINDMGLTLTGTKGTLILERDVLSDVQFGEYTLCEFNGKPLTSDEMSLVLLPAVIGGALVIAQFKNSFRGELELRSGRLQGVLASTMFEVDGFVKTMEDAFVSSTCGNGIVAHYDMSKLVLMDGRNRFVYELRPAIPDELVCQYMLKSFNGASVVSNNQLLLRFARSANGVGADVVANVANIIRGKVRVDGGKLMSKVMSSRKRGSEEEMRLEAALTCGFKDGFAWSLDDGVLTLEHTGNVLVFVKMAEVPCENGKPAYIGDKVTKCFKVHENGRIYRIVNTVEGRWAFYNDTTAYHFHVSVTFGRASEVTGLGNTTLRTNAEGLTVASVSVPPGGTEMFIAGHVNGYKCSYDAAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W459</accession>
    <name>F9W459_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_28810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000517">
        <property type="protein sequence ID" value="CCD11947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28810"/>
    <dbReference type="OrthoDB" id="1740299at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394544" evidence="4">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="13"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16955" checksum="4280F99D4767AFDB" modified="2011-10-19" version="1" fragment="single">MACFLNGIVVFVVVLGIFVKSQVNVDNDENIEPFSLLCRIYNVAKNPPITDVDLQEPHKIVEEIDALNRSLLEEKTHDKREEAGNHSEVQVKPTVTRETQVAQISLNQITQKAHAISEKIKKINFTENIGKVKADFAQVIFAENGNESDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A8</accession>
    <name>F9W4A8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_29220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000534">
        <property type="protein sequence ID" value="CCD11997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29220"/>
    <dbReference type="OrthoDB" id="1506071at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoI_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPOISOMERASE_I_EUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topo_C_assoc" evidence="2">
        <location>
            <begin position="171"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26291" checksum="32B6873BD35657E2" modified="2011-10-19" version="1">MNKVPVPPRGGPPAKIPVKVPFVVSRIGVPLAVPNPVARKRKTDSDEQDEDDAILGISQPSKKLKSAASVRRTPTDSETSSSDDTDSDYSESDESSASSTTDKGSESSSAVSDDELTFFRLALRKGLLNKENAQVEDPSQVEEQPVGAPPRPPVVRSFPRDIEATLKRYEDRLNREENMIRIKDDNKTVSLGTSKVNYIDPRIVCSWAKEHNVPITKIFSSTLQKKFPWAMEASDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4F5</accession>
    <name>F9W4F5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000549">
        <property type="protein sequence ID" value="CCD12046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29660"/>
    <dbReference type="OrthoDB" id="1708481at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19247" checksum="E46F004156A3EAEC" modified="2011-10-19" version="1">MAMRMKPSNHMASTLHRQQQTPRNTHCNAMQVTNCFTYILRAHPNGTCWGTNGPNRHLTAVLSTATLEYRKITRVSATLSDTALKKSHCAHSHEKAYCFISTELKAYTQAHGVPQGECQPTHQHPSVLPCETKHKLKTLRGGPCTPSSFWKVFGDGHFDEKHPKSVGRGIGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J8</accession>
    <name>F9W4J8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1190</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000564">
        <property type="protein sequence ID" value="CCD12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30070"/>
    <dbReference type="OMA" id="CHEVSTH"/>
    <dbReference type="OrthoDB" id="955454at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128029" checksum="B1A8C32655B41E50" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U3</accession>
    <name>F9W4U3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 122</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000605">
        <property type="protein sequence ID" value="CCD12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03190"/>
    <dbReference type="OMA" id="IKEIYIH"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="PTHR12866"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="31029" checksum="489072CAA18F25DB" modified="2011-10-19" version="1">MNKQSLYEGFKKAYNSVVGVKTTKNFHETGTLTPSEFVEAGDELLHKMPVWSWAEGPEEIQPFLPPNKKYLIYRGAPCYERAAGGPGGESKESEDEDGWVTTHVNHVRKSLTEVVTEKTIDWDNSDDDSSDVDLDRAKPNEAEQRRCRLYDVYMTYDQYYQTPRIFLIGYAEDHVTPLTTSEMMEDVYPVNRERTVSIDPHPFLQAACISIHPCRHAETMRRMIQHMKRRVEEESKGADFVFPTHMALFLFLKFISSAVPSIEYDLSTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W522</accession>
    <name>F9W522_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000645">
        <property type="protein sequence ID" value="CCD12269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="18026" checksum="C1629F341CFACAD0" modified="2011-10-19" version="1">MKFHFFAKFPFLPNSLFCQIPLLRKFPFSRNFPFLPNSPFCQIPLFTKFPFFAKFPFLPNSFFSRNSLLAKFPLFCQIPFFAKFPFFHEIPFFLLNSLFYQIPFFYQIPFFFFTKFPFLPNSPFLPNSLFYQIPFFAHFPFCQISLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5J6</accession>
    <name>F9W5J6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000720">
        <property type="protein sequence ID" value="CCD12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33270"/>
    <dbReference type="OMA" id="TTANNWG"/>
    <dbReference type="OrthoDB" id="803584at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="32144" checksum="ED6DED8BF9ED6D04" modified="2011-10-19" version="1">MRDSANHATAHFVAMETRELSLMAEEVKLSDQVRDLEDKRNQLYEATTHLNTLWNDLLERERRYFMEPVVDLSEQMRELHLERQNLEAKLSYQEDCLRAVQRELQQWDYVVKEKESLEQEISRVREQLMAIERRRKVSKGKAECLFEVESKRADAATRCVRNLDAQLHKMSQDGLASEAQRPVMSSRSNSRDVSLAQKSIIIDVDSDADYDRYSRRRGNSRRDGAEARELMEGTSYLPAQHRDEEDEEEEVYGIGGTSALYSLNDTKRVRIDVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5K8</accession>
    <name>F9W5K8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1337</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000726">
        <property type="protein sequence ID" value="CCD12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33390"/>
    <dbReference type="OMA" id="ARFMEHY"/>
    <dbReference type="OrthoDB" id="920847at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="26"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1763"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1873"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2067" mass="218080" checksum="708230090C8C2FFC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5K9</accession>
    <name>F9W5K9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1337</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000726">
        <property type="protein sequence ID" value="CCD12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33400"/>
    <dbReference type="OrthoDB" id="1737932at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17637" checksum="B15AB66874BB0825" modified="2011-10-19" version="1" fragment="single">MLQDQRYDVRSERQQQLLRQQFRHGQMNQYPSWEGRRNPWPQPQQTPAGSGSLQVDQLGRDDAGPPGYNPRAGNLRFAPTQGSLQQVVGTRNPSTSFVLSNNESMAEPRRNTPRGVMAEDGSSEEKGLESTQTDSSSRRKGSKGMWGSMKKFLGISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L3</accession>
    <name>F9W5L3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000727">
        <property type="protein sequence ID" value="CCD12465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="13974" checksum="ECBF7BC7AF478987" modified="2011-10-19" version="1">MLGATKGGLWPWGQLRGNEMAHLNHVAFLFCWIVGGCLSFNTHAIYGGQGVRAGGGGAWRCCVSGRDLTSAVVVMVIYPNCLTVRMTRWRDVEALLTCTECDGGSWPGRANGISLTAGVLLRVAGYWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Z4</accession>
    <name>F9W5Z4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000804">
        <property type="protein sequence ID" value="CCD12597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16283" checksum="C319328F495776DB" modified="2011-10-19" version="1">MPSVKLIFRCRHSKPQPVRDKQLSASLYRRPFRSQSRLEPAALCQKGSKAATAAIQRLGPFSHASQQSPNEKRKERNGSIEGKDPYSNEVTAPTAGPQGSCSGTHTHQLMKRVEQIKSGVCTVEDKQWEKAISACNGQFMLLEKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W645</accession>
    <name>F9W645_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000821">
        <property type="protein sequence ID" value="CCD12648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35090"/>
    <dbReference type="OMA" id="AVLQCYQ"/>
    <dbReference type="OrthoDB" id="1561535at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17081" checksum="0B9A1CE9456CEA46" modified="2011-10-19" version="1">MSSTNATAAPAAAIDDYTPEEHLTSIVMEYRKLEAVNQNSVERMYSSFSSPFKIGNKPCEAARADALGCLSEVIGGFRSKNVVGREDVHADSSESLRAERDFPPVHRCHESVLAYETCILEKSLPKHNSLVASFEARRSQEAEMPSRDGAVAATSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W680</accession>
    <name>F9W680_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1432</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000832">
        <property type="protein sequence ID" value="CCD12685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35440"/>
    <dbReference type="OMA" id="CMAVYGC"/>
    <dbReference type="OrthoDB" id="1696379at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="241" mass="28300" checksum="22E6E1E7DB918161" modified="2011-10-19" version="1">MALYHTISLYHTIALYHPMALYHIIVLYHPIALYHSIALYHIMALYHTMALYHSIALYHTIALYHTIALYHSIALYHPIALYHTIALYHSIALYHTIALYHIIALYHTIALYHTIALYHTIALYHIIVLYHPIALYHTIALYHTIALYHTIALYHSIALYHTIALYHTMALYHIIVLYHTISLYHTIALYHSIALYHSIALYHTIALYHSIALYHTMALYHIIAPESHNSHYITTYHYITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J6</accession>
    <name>F9W6J6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000887">
        <property type="protein sequence ID" value="CCD12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="631249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13648" checksum="20F1A41A9C534C3C" modified="2011-10-19" version="1">MKDSHLRILLPALTKCTRLTSINFYDNNISRDVLQDLLHRTANMSQLTMELYPAPVEVYNEWSYVQVERFSQLCAELMNTLITVRRPKSVCFGTYSCYDCDTHCIYGNQTTFCECLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6L3</accession>
    <name>F9W6L3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1488</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_36680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000893">
        <property type="protein sequence ID" value="CCD12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36680"/>
    <dbReference type="OrthoDB" id="1653500at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1646" mass="185341" checksum="3DDFD17838FDD2FB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6W5</accession>
    <name>F9W6W5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000942">
        <property type="protein sequence ID" value="CCD12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03840"/>
    <dbReference type="OMA" id="EGHTHEM"/>
    <dbReference type="OrthoDB" id="160788at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="807" mass="90002" checksum="7EBD683AA336500F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6X8</accession>
    <name>F9W6X8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1533</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000945">
        <property type="protein sequence ID" value="CCD12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37560"/>
    <dbReference type="OMA" id="PYHINSM"/>
    <dbReference type="OrthoDB" id="1294194at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="289" mass="31201" checksum="E14DC35D39EE4D73" modified="2011-10-19" version="1">MTRGDRSQYGQSSRHRRRLSRDIDEVVSDELEPRRRHRQHGHRRRKRTRERHWSARRGSYASSDGSVDSSDGRPARRQRRREHSQDRSRPLHSTAALEKRPADWRKEMLSVLDEQLNAHCRSLGPSGNNKAALGSSASTGGVGDVRTADDAPGAVAAPLKSSLGCVVLHGVDLGVQPYHINSMLEQLVGLRPLSVVRPAAQLWETIRSAAIDRITAATDDGVVGSDGKPVDLRFVTPEGCRHLGLHDASAAGGIVVLELSQASDVAAVVAALNGACLNGQFITACAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W776</accession>
    <name>F9W776_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000993">
        <property type="protein sequence ID" value="CCD13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38570"/>
    <dbReference type="OMA" id="FLWSDHW"/>
    <dbReference type="OrthoDB" id="1017377at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="38984" checksum="87F34DE90A97CCEA" modified="2011-10-19" version="1">MGGSKAAELFWVFESAAQGLHMERRRLLKPNGIHNLIDINGAPFKCAADAAEATLWRTHHAFSGRCGIGEAAGNNAEQSDSYGGLHDDIGANGPPTSHTAENYRDWTVNLHLRSYSAEPHVLVSVAPHCLPSRGKGSSFVDSVYAKDEGACRWPRDWGPQTKEEQSAYDAAVLGTPLIWEEPLVLSVECTTAGMFLWSEDYEMYGEKVADRCFEKRDESFSGMDGSSIHKAGDACRAESLYKAFLRVRWRERQSAPPGEGNEGCCRDGEEKSADLFDLDRCSELYVYQGAPGVSKGLASGGNERNDPSGSELLPHNEGVTWRQVLHRLIPCGSLPVNVHFAPYVTLMDGGDEALLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7I1</accession>
    <name>F9W7I1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001037">
        <property type="protein sequence ID" value="CCD13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39260"/>
    <dbReference type="OMA" id="NEVSICA"/>
    <dbReference type="OrthoDB" id="479815at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1041" mass="110608" checksum="DE2F71E772FACA0D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7M7</accession>
    <name>F9W7M7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001054">
        <property type="protein sequence ID" value="CCD13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="16157" checksum="091E2502DEDACF43" modified="2011-10-19" version="1">MLFLSLFFLPFFLPSFLSSFLSSLLPSFLPSFLPSFLPSFLPSFLPSFLSLSLSFFLFFFKTQFFGLHLALNSINSCFAWRGENLQVCATKPGWLSFHNPMLNQSLIRGGLLTLNQILILHDHFYYWLEKDRDELLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W806</accession>
    <name>F9W806_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_40930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001116">
        <property type="protein sequence ID" value="CCD13330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389980" evidence="3">
        <location>
            <begin position="22"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="307"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="444" mass="49083" checksum="A44936C92A627573" modified="2011-10-19" version="1">MIMIKTFLLVALVFCVGLGSGQPSAAEFNLFCRILAEASDMMYGPGYVYDENADRETIKEMTVLYNATTANMKDFGNSLWDRKEFLKEHPPPMNPKNREAAHREIKNFIDKVEQKIEDNRKMAEEVNEKIKEAQLSVAQGIYGGNVTEVPKQDGNLTEILSNTESIFNNHNSATKSCGNSTGTGKTLLNDFFVCVWETVSQRVRGPVTVPSCHPRRAATIAAIRIAAALIPVAIIAATPNCCGCGWKQMKYQTAGRPALSLADSIKAIEEVCNEELMAEVKQTKDMNGLLAEYVGLIGEGAAKDQPNGKKIFGHSRRSKGNNNKVTKCDGSGDGSGDGNNGAQETANANICVDYSNHFKDDKYDIPWHNKFRNYTNLMEQAKNLEEKILKNRAALLLLKTEAWIAYSREKDDETSNIDDMNVSNLLDGTQLPPSLPLSYLAIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8M7</accession>
    <name>F9W8M7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001186">
        <property type="protein sequence ID" value="CCD13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="17143" checksum="6D7FD532797E97E1" modified="2011-10-19" version="1">MKKGSNFPSEPFPLCLFTSVFQFSPIFCPFKYKKIFLYLKVRVFGAVLHLHRFFLFFAFSANIYTQFPHFLSVPRNDYKKTFPPRRCTSCTFAVCCFFFFFVLIVFYFNLYIFFVLPILLLFVLFVPTGGAEPLRELSFCGPCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q9</accession>
    <name>F9W8Q9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1762</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001200">
        <property type="protein sequence ID" value="CCD13595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43340"/>
    <dbReference type="OMA" id="KKSHECW"/>
    <dbReference type="OrthoDB" id="280984at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="748" mass="80358" checksum="F7C401DD0B9A6B36" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R7</accession>
    <name>F9W8R7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1769</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001207">
        <property type="protein sequence ID" value="CCD13603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43420"/>
    <dbReference type="OrthoDB" id="1573712at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="23099" checksum="134B59B03410D311" modified="2011-10-19" version="1">MGSANCRSNCGSQNQVRQVSDSESEDMTLAAKSARECLQQAAPPETGRRRRSTKLAEDGTNAKPQPRTRRQTKLTNGTNSGEEAPVKRRVRQKNVVGASADEKKGAEINGDSNAPTATRSRRGTGSTVRKRGRASEESKKHNGNEVPPPPAPNTKPSVNNTPSIEGDGLARTTALKIEEVDDETPCETPTQQTSYGQVCSAASRGYSLGSSLTSTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8S3</accession>
    <name>F9W8S3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001208">
        <property type="protein sequence ID" value="CCD13609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43480"/>
    <dbReference type="OMA" id="NDATLCY"/>
    <dbReference type="OrthoDB" id="531731at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="41288" checksum="3794017DCC7CD2D6" modified="2011-10-19" version="1" fragment="single">MTDLGSVATVDSSRRVRTGFPSNPPIFAAGVRKFISRPLPHSVDAICSVELPCGSVVLAAGGCVVSAELVSSLMHPYERSGAPQSSFPHSEPTAATGDSSSEMPTLIASSGLITCMDITLLPGGATALCAMGTSCGSLCLFVVESRPTGGTPALCKVSETPLCEYTDGLISAEDIVVDVCIGLDPAGRPEFVSAATSNVVVVIDTQYFDDSLKANATEAVSRVVVRPPPHSAYTTERPFSETFYASFSATEVVRVVAPQRHHASFAVDVALLIVFDNGDLRYVARHVVGGSLQILTEHHRQRQLRHSKIGLDMVLRDNEFSSNASRGPLALPHVLYAYSLSAVSHNVCTTAAGPNAAAHKVVNSAALFFDAATEQMRLVVSGTETHLTEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8S7</accession>
    <name>F9W8S7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1772</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001211">
        <property type="protein sequence ID" value="CCD13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43510"/>
    <dbReference type="OMA" id="QQPATHI"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138779" checksum="C732F2977FE52392" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W968</accession>
    <name>F9W968_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1829</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001274">
        <property type="protein sequence ID" value="CCD13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44650"/>
    <dbReference type="OMA" id="RWIATQW"/>
    <dbReference type="OrthoDB" id="1506145at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="296" mass="33188" checksum="4AA5CEA2B214A9A3" modified="2011-10-19" version="1">MNPEPPTKEEKDSRGESTIRVGSQLLLRKVPLLAKARACAQQDPGDPDAECNVLSDGPDVYRICSLISAGNKDHAVFSALPHKRRRDGGEMGDEALDSQLVLPTRMEFLTLLESRLNKSSLPHHSPTEEGEVSEKNLTHSSGKRDVERNDESEAIALRDEKHYHPACGQEERKMLDAIRKPLEGKIAPLFGVENSTGTVSTGGKSMKRVPWEDMFETLMNRSSGAGAEGDAVRSYLRRVSWIAQQKKQQLFLTGAAETLTSDRQSWASMSESARVQKEIMHMRAQRQRFHRERKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W983</accession>
    <name>F9W983_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1832</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001278">
        <property type="protein sequence ID" value="CCD13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44750"/>
    <dbReference type="OMA" id="CENTEAS"/>
    <dbReference type="OrthoDB" id="1101821at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="583" mass="63269" checksum="29B26D312654C843" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9A8</accession>
    <name>F9W9A8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1842</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001289">
        <property type="protein sequence ID" value="CCD13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44980"/>
    <dbReference type="OMA" id="NINCCCI"/>
    <dbReference type="OrthoDB" id="1295943at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="510" mass="57836" checksum="9451E7B68F6D4BE1" modified="2011-10-19" version="1">MNNSEQFDDKKAVAGNMPARHSQLVSREQMSVHSSTAGSATTERAFEECASVSSTGAADHISGHRYILINNILCRTESPSGSFRPQDVFCGLDPPPRATLALGDVSPHWSALPKGYNRDLRSRADSVSRDCPIFNVFGVMSGGVLVEHPGCGFLDFTDSKVLNPTVSADDGENEEYYANGDYARIRAEGFLTLFSSIHPYNAEGSTDTPLPWPRALPRMRNINCCCILAKKTSSRIIRRLRSTVQINHLLVEIFERYRHGLKVQVHQATYLPTEIPFRFQCRGMTFRYKNLPLKSYDPQYLSTHRVRKRPNLTRTNNHKMDDLVGSTYSEFHTFTGLPKMTGKKYTDVVSCGRYQLGTPPVGFSQRAEMRVQSFVHPLREEMAVDKSVHLSYKSKCAADMWYYFQRYFTILRVVPCTTCNTPDCAAWLFEDDKDVDYLEAVRNAEMNRYDKRTTNTSSSVIADAWDYLYVHERRALAARLGVIVNCVKRYDAETNKRVFYAGAGVYQLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9G7</accession>
    <name>F9W9G7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_11_10510</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45580</name>
        <name evidence="1" type="ORF">TCIL3000_11_10510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001306">
        <property type="protein sequence ID" value="CCD13867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.10510"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45580"/>
    <dbReference type="OMA" id="FQLDTVM"/>
    <dbReference type="OrthoDB" id="931915at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC95578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="306" mass="34430" checksum="26046F02C19E7C5C" modified="2011-10-19" version="1">MVLRRNCCVTVTTNCRNVDVCLRGSLAVCGDYRYVSCGFRPRLFDAVFVMNLDRRPDRWEFATQQLRRAGFQEEEYTRFPAVEGELVDISKAHGCGLISRLGLLRLREPEMRRIWGMDLSPGAVGCALSHALLWAQIAASRFRAALVVEDDSMFPEDFHRKYEERLQHVPEDWDLLYVSGLDTAGQTPQLRVAEGVSRVPQMHRTTNCYVVSHRGARLLLEVCFPIIYQLDTMMTMQTAVGSPGSQPHVAVPMCYTLQPPLVVQATRMGTDIQSGTGGVCRDEKEEERARCRAAGWMDHEEAAGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9H1</accession>
    <name>F9W9H1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1860</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001308">
        <property type="protein sequence ID" value="CCD13871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45620"/>
    <dbReference type="OMA" id="AAFHFSH"/>
    <dbReference type="OrthoDB" id="744631at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="496" mass="53827" checksum="8D9E66411B79ED09" modified="2011-10-19" version="1">MRRFPSAFPTRPLLRAPRFTRHCQGTPETPDTIKNAIAADEMAQRRREEAVDSRSVVFACGSSADHRPRIAAAEAFDVAAAALPHTPNFCFLNVSFDYAAMVDAPEVVWYNLCRANSVTPSTVRPQELHMIGGATRMQRPGGGFIQVLLGCIPDLQSDIFTFDTVPEEEDLKEPNRPPPAICFAFMDSRLTLQYERQLTDHLQVLGERLGECPLIGGVYPASQKSANDVGSRTGGDGNDQSLNSEMGDSLFYLNDRVYVGSAAGAVIRSKMVKARFANIIPSISVHKARVTSCSQYAKGVYTIEALDNRRATDVIRDIYCLPEMQGKPSKVFLGLHHGDLRVPVSFIGDPSSGELRFTAPKRVEVHSNETIELLVDDVELDSEVGAGALIGLQKQAQIKYVEKDINVAGDARRSVVASSAAAFHFSHPGMNVLVHPDVNLTLGSSSVLYAPSLLQRCLGRFCPSTGAFCPGQVASFDGVSGVFSRSSSYAILEGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9J1</accession>
    <name>F9W9J1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001319">
        <property type="protein sequence ID" value="CCD13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16199" checksum="259777699C56C472" modified="2011-10-19" version="1">MGRTRTVTPHARMAITPQLTATLHHWRQHLLQGRAAKVSWHHASLPAANTACTIFSCVLHPNAHRNKSRSSCKACSSTPKQIASRAVKVRLLFLTFVQLWSPSGTHARPLHSLRKSKPSEVKAPLRQYGPFDNAVLASSVRCDHIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9N4</accession>
    <name>F9W9N4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001333">
        <property type="protein sequence ID" value="CCD13938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15127" checksum="39988CA100B653F0" modified="2011-10-19" version="1">MASSCMEALATRRKGRAGGAANVPANGVTETNQTAASFRHTAIGGLSVASSVGHPNERNPMNAAFVAIKPQKPKLARALEKRQVHAELQKAKNLKRMGERGCQTVAPYRRPLRATSKGSGGISAPTFHMHSVLHWDEALQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9N7</accession>
    <name>F9W9N7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_46260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001333">
        <property type="protein sequence ID" value="CCD13941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46260"/>
    <dbReference type="OrthoDB" id="1663921at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394626" evidence="4">
        <location>
            <begin position="24"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="88"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="425" mass="46365" checksum="269ABAA0A4FC4041" modified="2011-10-19" version="1">MVWFMNVLLASVFVCSLWGEAAAQGAEVKSIDNAEQFALLCRIYNVAKNPPINHVDLQDPYKIVEEIVSINASFAEEKRLNETEQVGNSSYDQVKPTTTREAAVAQAILRRITQKAHKILEDILNMKATRDIKKIKAEFAQVIFGEDGNESDLCHGALKGVSGRAEACGMTGLSHKGASAGENLVVDFFCLCAQNTEKNNGIEKVCGVQVGGKGDKHGWSDQGPLGSASMWVSIKKGCENLLHQHPKSTEEGHEIIRDFLKHLETGGVYHWGSNTLKGSDRKAGMLGTAAGSDDGAKGSDLVCDGKKGYAGGKKPNGSPPGGICVYYGSEDEWQNIPWLNQFKTTLNTVDAVNNKAATIQGDIQKLQMLLHRAEEIYVTAKMITEIQSPQGLAAFTNTTAKRLTAFNAVRRYSPYHFIPAWMIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA45</accession>
    <name>F9WA45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1931</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001387">
        <property type="protein sequence ID" value="CCD14101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47680"/>
    <dbReference type="OrthoDB" id="1728741at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="17932" checksum="5E7CD17E0DBA73E0" modified="2011-10-19" version="1">MEFIREKVSTSFSFDFRPAETPSVTCHVGGLLTIEDVNLMAYFDCERKMDFVSLRQSMVRFTLPGNSDFLRASGEARGALRAEWTALEATESALHNQFNSACAHSSQMRVSTCSKVRMSSCSECNNSSCVCIRDCCTAGSAVGSERQNDCYVTGAAGWSRCKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA65</accession>
    <name>F9WA65_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1942</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001400">
        <property type="protein sequence ID" value="CCD14121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47810"/>
    <dbReference type="OMA" id="ERRNPGP"/>
    <dbReference type="OrthoDB" id="1283205at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="SSF116846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="227"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="555" mass="62980" checksum="FDE8D1AFF8428BA9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT7</accession>
    <name>F9WAT7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16040" checksum="62BBFE24D399BD01" modified="2011-10-19" version="1">MLRYNVGASTRHRAKIHGTTCFPFFLKRKKGKDNKSRRKTHCCATGNNVSLGSTRHFLASPLQCPLPPLLEGVNYLKVVRFVLGNCLLLQLTVLESSKLAFPLVRKLPLDALPVDKHKHREHNAEHNFGHLKTLNDIESNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB84</accession>
    <name>F9WB84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001545">
        <property type="protein sequence ID" value="CCD14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51230"/>
    <dbReference type="OrthoDB" id="1716689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="17965" checksum="71FD5A29455ADB43" modified="2011-10-19" version="1">MQLLGKFLDSFLPPLILFDVVGWVFQESSESRIGVAGSVCFPIFLSQKVNEANVFPGFECLPEDPLQLTVPSSSWLTLCAWSAGYLICELVTFLVASLHGHASACCGDRGCLRASRTASSKMGLGVQANNVLAPRRAQSQRVMMPSPTRHRMSLIVLSCKRSNVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBA7</accession>
    <name>F9WBA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2083</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_51450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001556">
        <property type="protein sequence ID" value="CCD14538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51450"/>
    <dbReference type="OMA" id="LKLRRAW"/>
    <dbReference type="OrthoDB" id="864371at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="443" mass="51725" checksum="FA33D6CD64B672D2" modified="2011-10-19" version="1">MPTLTTKIKGSNNYFSLISLNINGLNSPIKRHRLTDWLHKQDPTFCCLQETHLREKDRHYLRVKGWKTIFQANGLKKQAGVAILISDKIDFQPKVIKKDKEGHFILIKAKILQEELSILNIYAPNARAATFIRDTLVKLKAYIAPHTIIVGDFNTPLSSKDRSWKQKLNRDTVKLTEVMKQMDLTDIYRTFYPKTKGYTFFSAPHGTFSKIDHIIGHKTGLNRYKNIEIVPCILSDHQGLRLIFNNNINNGKPTFTWKLNNTLLNDTLVKEGIKKEIKDFLEFNENEATTYPNLWDTMKAFLRGKLIALSASKKKRETAHTSSLTTHLKALEKKEANSPKRSRRQEIIKLRGEINQVETKRTIQRINQTRSWFFEKINKIDKPLARLTKGHRDKILINKIRNEKGDIKTDPEEIQNTIRSFYKRLYSTKLENLDEMDKFLDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBQ3</accession>
    <name>F9WBQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_52810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001612">
        <property type="protein sequence ID" value="CCD14686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52810"/>
    <dbReference type="OrthoDB" id="1676284at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390116" evidence="5">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="58"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38608" checksum="D86B6A5C4D482F19" modified="2011-10-19" version="1">MMKLKCLIVVVMCLAVMQIVGAESGVAEGTKDHNKEAHHLLCDLMKAAVGKWGRSGETLSEPLKKALGRTIFGSMTGGSLEELRRELPDFYEAVLKGIADRSTACGGPESGQSAPYDMVCLCTLGNNSWPLDYIRTATTLCGQNKNDLGSEKGSKGWSDRGTGFEQITATWFNVIKHCLEGDKEKGEKLKEALEHFLGKLKNKPYQGNDRYQLGEGEPESYSACTGTKTTGVCVMYYNGTFVKKDRIPWWQDLQNALPEEEKFQEEKRRAEEEKRKQQEEAAKKEAKNTEDLKSGPQANNQTERSQKDKLHEAIRKYNMKSGTPKTSSMFMASHCRYFDLKEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBR6</accession>
    <name>F9WBR6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001618">
        <property type="protein sequence ID" value="CCD14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52940"/>
    <dbReference type="OMA" id="DKHESAF"/>
    <dbReference type="OrthoDB" id="480283at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="532" mass="58633" checksum="671622973232B4F8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU1</accession>
    <name>F9WBU1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53200"/>
    <dbReference type="OMA" id="NCTTWRP"/>
    <dbReference type="OrthoDB" id="1656387at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="637" mass="72627" checksum="AB6FB0BB83E4872F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW4</accession>
    <name>F9WBW4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001635">
        <property type="protein sequence ID" value="CCD14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16789" checksum="E8130B1871386828" modified="2011-10-19" version="1">MYEIITACASSFTRKLIFIFYFINLFFQPLFSAPFVVTCIPICAPRHLSPHHFNLCPPFMQKLGRRDITFASTFFSFHLLFFTQGHLLTRLPSTTTVLVAFKKVAQLCETFHSSVFPTFAQFLLRCSRTMCHRFPHPSPHTRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBY4</accession>
    <name>F9WBY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 216</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001643">
        <property type="protein sequence ID" value="CCD14771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05610"/>
    <dbReference type="OrthoDB" id="1731563at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16752" checksum="95DB56B4C1BD4900" modified="2011-10-19" version="1">MHGTHAHTPGTSSDAGCTHTHGRVQQQDTHCASATQHVMHLPHGEETKAGKPTHMFSFVYFQYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVYREAHTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC12</accession>
    <name>F9WC12_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-exporting diphosphatase</fullName>
            <ecNumber evidence="2">7.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_53850</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001653">
        <property type="protein sequence ID" value="CCD14799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257116at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390129" description="H(+)-exporting diphosphatase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD14799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="454" mass="47264" checksum="53498A9824FF16EB" modified="2011-10-19" version="1" fragment="single">MNPKPLLLAVFACLCGIAAAVDGEKQPRLVPSKNVTINYLSSGGSAKGKASHDVEDVLPVDGVGQLMGATAATLIITFASALGFAFAMYWWYVASDIKITPGKGNVMRNAHLTDEVMRNVYVISKRVSDGATAFLFAEYRYMGVFMLGFGALLYFLLGVAMSSPQGNGKDSHVSSVQAPWVNAAFSLLAFLIGALTSVCAGWIGMRIAVYTNSRTAVMATVGSSGSDDDVLVSGSQSQGYALAFQTAFRGGITMGFALTSIGLFALFCTVKVMQAYFGELPENMPELFECVAAFGLGGSSVACFGRVGGGIYTKAADVGADLVGKVEKNIPEDDARNPGVIADCIGDNVGDIAGMGSDLFGSFGEATCAALVIAASSAELTADFTSMMYPLLITAGGIFVCIGTALLAATNSGVRWAEDIEPTLKHQLLVSTIGATIVLVFITAYSLPYSFTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCA7</accession>
    <name>F9WCA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_54700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001693">
        <property type="protein sequence ID" value="CCD14900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54700"/>
    <dbReference type="OMA" id="DRSENIC"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394672" evidence="5">
        <location>
            <begin position="23"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="96"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="245"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="446" mass="50571" checksum="035B2499E6FFFB4D" modified="2011-10-19" version="1">MRKAMCILEFLFFMIFFGGASSGASDEQYNKEEFKQLCKILKVAEGEPPEIPDELGKFLETRKILEKLLRATKTSMATYQKVIQLKSSDKEDAEFVSYTVKRRIANEKIRHAMEKVKDVYNRMEEELIQAKKERTLARNNLVHAIYGVQVGELPEEKDISDVLKNVSRSSISNNDGGLKKVKYHDDSTEPTCGETGKNGPGFTLINDFYCLCVGKDNAKAVCHKDISGPCCCCCKDKCSPGCKCEKDCNCGDKCQGCENYNKWMYLFDVNQGKIVDLPQGWKRIRKVCNETVKDKTNTTAESIQEVLDEFNKLLGKNSSKKAITPKDAEYDGRRLFVLGFAKQVTNGKGCNGNGGNDAVCVNYWGVSNLGIGIVWQNYMLEAQKHLQEMDKHIKKASQLSTMIQMLKDSAEESYSKVTHDNEAWEDGYGFREHPFFNLLIFWVGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCM9</accession>
    <name>F9WCM9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2249</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001741">
        <property type="protein sequence ID" value="CCD15024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55900"/>
    <dbReference type="OMA" id="ANDAMSN"/>
    <dbReference type="OrthoDB" id="1679120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="39013" checksum="DBCFEAB86124BE5E" modified="2011-10-19" version="1">MEHRVIFFPSVVSMLVDRGTCANCVCVFIVMVMLSVPRLSCCRATEGALWPLKECASNLCAVRRSLDNVQKAVDAIIATMGERVGEVKSLLKVVEMRREATAHLAATARRRAGGFRLASLIVTRVNAAVASTTRLVEETEKVYDEILSLSAAAKVRANEALDNATAASAIIFSILAKTRDAGNIHIGTGECIAASTDPALTSRALAAHKESLALTDKKYGSEYPILREAWARVYPKLFVSLVQAEFLLAHLEWDGSRAAELVESARASVRAATEAQMAARNAAKEAEADASRAGLARRESIRAAKKTAAFRVITGFREPSNLIKGTLVGETGISEEYVANMCFSRGGAVQALALLAALTRTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCX4</accession>
    <name>F9WCX4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001784">
        <property type="protein sequence ID" value="CCD15122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56820"/>
    <dbReference type="OMA" id="HIVKENM"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="813" mass="93242" checksum="9ACFA0F3AFF7645F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD26</accession>
    <name>F9WD26_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_57230</name>
        <name evidence="2" type="ORF">TCIL3000_8_5600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001811">
        <property type="protein sequence ID" value="CCD15174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_5600"/>
    <dbReference type="OMA" id="VINSAEW"/>
    <dbReference type="OrthoDB" id="1608321at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC92338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15173" checksum="BA1E3CEB1C502263" modified="2011-10-19" version="1">MKHKDGRGQTPPPLFSITNQKTGEVLLEITSVPPNNAPLPPVEEECCGQFNEALAFIAEAQARSYELFGHIVANQTESHSVLANAAPVPGQRNRFVEAVIPEDTRSTSLINSDEWDVDGFDGNGSDTSEREPLQKKART</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDE0</accession>
    <name>F9WDE0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2358</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58240"/>
    <dbReference type="OrthoDB" id="1706206at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23369" checksum="DE4D21B8D57AD057" modified="2011-10-19" version="1">MKLVFTCPAEVEVELTVVEVVRASLEPLETARGFFRGLLHGARQYDAEDGHTLTTDTLQKAMRQVVFEDEGGGDLQTLAMRRWTTTLRYALDPETAMHEFLLAFLGELQTLDSFVENHRGADAFHQAARRIVFGEERPSERDLQTLAIQYVARSVLQSEDPEKKARELLGGVLHEARHLDREHHHHQGEEALLKAMEEILQKSSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ9</accession>
    <name>F9WDQ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 239</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001899">
        <property type="protein sequence ID" value="CCD15413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06070"/>
    <dbReference type="OrthoDB" id="1716547at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="18163" checksum="014626E09320B09E" modified="2011-10-19" version="1">MPERSFCIAWFHVVSRCYAYFFSGTLPCIAVGVHLPGVWSGIILIVFFRTAHPPRQKVWLDVHSPNPRMFDRAHCESLHAPRRRQQQSWEVPGFVIIGYRCIFTISVGHSKAGRPYALSPCEARAGDVRWRHSLLRSIVRKPRRNWQKNRLRKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY3</accession>
    <name>F9WDY3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001929">
        <property type="protein sequence ID" value="CCD15488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00730"/>
    <dbReference type="OrthoDB" id="33214at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="821" mass="90310" checksum="166546053B643D9C" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDZ9</accession>
    <name>F9WDZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 242</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001933">
        <property type="protein sequence ID" value="CCD15504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06260"/>
    <dbReference type="OMA" id="YIQHENS"/>
    <dbReference type="OrthoDB" id="1656372at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="757" mass="86796" checksum="8C8A4C857521FC9E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE04</accession>
    <name>F9WE04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_60150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001936">
        <property type="protein sequence ID" value="CCD15509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60150"/>
    <dbReference type="OrthoDB" id="1668988at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394919" evidence="10">
        <location>
            <begin position="25"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
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            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD15509.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43457" checksum="F854C4B764D88BFB" modified="2011-10-19" version="1">MVMELRINWWWIVAVFMAWSSAFGEGDTPKAIPTKAGAAICTLSKTLKDVTPWATQQVEEGSAKVTNLEMKLLEWQTKWVQSKAQGKGSETCKMTGLLFRQVRKEIDKVREEVERLEREASKAAAFAANSAGRLDEFITVFANAKGESNGFCLGDTNAAKPEDLRDCFSKTDFSEESLVDIGERASAQEPNLFSRIESIKYSKLSSHFTTGSGGGCNLVKGASGGILGKTDLEKSLWWGGGILTIGKAFDGVLNRENFTAGEIRNAENGGSKAFWTADPATQIVHLKNTSDAFKAFKAVKEKIQEKVKSIEDKMEGCLTGQEPGQNKTEPNATEPTTTTEETTTSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPTTRFLGLLTFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE22</accession>
    <name>F9WE22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2430</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001942">
        <property type="protein sequence ID" value="CCD15528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60340"/>
    <dbReference type="OrthoDB" id="373502at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1166"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1625" mass="175625" checksum="B0B978B4FD00D3F1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE81</accession>
    <name>F9WE81_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2445</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_60730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001959">
        <property type="protein sequence ID" value="CCD15587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60730"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="520"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="77"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="599" mass="68369" checksum="5A1C09A5142A0BC2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE84</accession>
    <name>F9WE84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001960">
        <property type="protein sequence ID" value="CCD15590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60760"/>
    <dbReference type="OMA" id="ACTEIEH"/>
    <dbReference type="OrthoDB" id="40170at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Exonuclease_RNaseT/DNA_pol3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="338"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="732" mass="82261" checksum="350A02C104A2D2A6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEC1</accession>
    <name>F9WEC1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2457</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_61110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001972">
        <property type="protein sequence ID" value="CCD15628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61110"/>
    <dbReference type="OMA" id="VLFARMF"/>
    <dbReference type="OrthoDB" id="807855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="416" mass="46029" checksum="CB0556CD0E360C10" modified="2011-10-19" version="1">MGCVPLATSHLLQRLRSLSKSQQYASKHAFESDCADLVTMWTNLPRMSGTEMGADLLELISMWPDFVTYGVAYVVSNDVLSCIRPLLEAVLASNAATLASSTEALFHYVIAANAGCIEELANTLADIVTQRTLALTSLMPPLDLMQEVQFVIDLLEEYQFPTHDRDSTHHGDSSQPSTHYSTAGVLRAYVGLVERSATVFIQEVAFPSYCNMHCFPAPTCVLVRGVHPAIYFCFSTMLSLIHGHRRSTKITDERPCRQVVAQVWIWGCQAIISVVKRGPSASIQEQIVRDTMHYVLFARMFRDFIGERYFISVSKSLVELLGVVALHTPDAKVSEAGSEEVPNFENGIWGVAPLSEMELFQLTDNSRGDGAKGLICGDTARGLFLPWSDAFIRASNADAARKVPHEWRSTCFARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEH0</accession>
    <name>F9WEH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 267</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002012">
        <property type="protein sequence ID" value="CCD15680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06940"/>
    <dbReference type="OMA" id="THEGSHE"/>
    <dbReference type="OrthoDB" id="1455324at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JAB_MPN" evidence="1">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="39780" checksum="6A0E1E63AAEF0CC0" modified="2011-10-19" version="1">MPTSVGDFIVGTQRVCLHPLVVLNITDHVSRLHGLNCCDRGSNVPKDLVVGILLGRVTHEGSHEICASFEAVGPYLSQSGDVHGLDWGAMKQKREQLAQVTPDLSVVGCYVNLRTMGDVARCCAAVHYNLRGEFCEVSEGALFAMIVDYNRNSKLSPSPIYLFEASFLTDPGEPQTCCEPPVQNEVTSSAMCYEVSSTSLSSAMPNNARFDVVLPNKSRLPITMKRIDYVLQEEDAQQVGLDLTLRISADIDDTSNSITTTAIGLQLHRVALSLQLLRNKTQQVIKYINTTENNANILLDTEVLRHVGKVCALTSSGFSSALSHSEWAGGGGVCMKGHVAQLVALLSLQSRCVAGLQALLSAHRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI0</accession>
    <name>F9WEI0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002015">
        <property type="protein sequence ID" value="CCD15690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="109" mass="12008" checksum="67E5BF4E5C4BBEF9" modified="2011-10-19" version="1">MLACSYRTKCIAMKTGLQKLVHVIGAGNLTKATRVTLLADSLSLLTALKIGTVVNEAMLRRIWDIILQLRRLRAGTSSYFVFSHRGAHRNKSKDRAAGAGNARPQNYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK2</accession>
    <name>F9WEK2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002026">
        <property type="protein sequence ID" value="CCD15713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07260"/>
    <dbReference type="OMA" id="FRCRMET"/>
    <dbReference type="OrthoDB" id="222689at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20534" checksum="C084DBAA3627B347" modified="2011-10-19" version="1">MEDEALHRFDEVWNLMIAAGGIAKRGMEFHLRIATGDAHVMKQAVVSLVMLLICQQKDGLHHFLWWRARCRSAAWSEVRNTKNNYGAEVPHGHTSQYLSAVCNESVALFDLMASFFNVDLPRVIRACFRCHTESGELVELDRLPMGYEGSTEIVHTITRALAGDADVVRTEHAAPNHLRIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK4</accession>
    <name>F9WEK4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_07280</name>
        <name evidence="3" type="ORF">TCIL3000_9_5190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575322">
        <property type="protein sequence ID" value="CCC93112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002027">
        <property type="protein sequence ID" value="CCD15715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_9_5190"/>
    <dbReference type="OMA" id="YVTHKRL"/>
    <dbReference type="OrthoDB" id="1520814at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="PTHR11886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="SSF54648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC93112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17333" checksum="F59C2C3E6ED8799B" modified="2011-10-19" version="1">MSRSSRQSPPGIRQSTRLSSVGGVSNRSSGPNTDPELDPCASSLSRVAVYTDIPDKTLQRIMNIATEAYSRFVLVPTRNTWRKEEGSRKELEREVERTALRDIAQAVKLNVEAALGGTWHVIYGRSFATYVTHQQRCFCHFQLDGANVVVWRHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK8</accession>
    <name>F9WEK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 284</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002031">
        <property type="protein sequence ID" value="CCD15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07310"/>
    <dbReference type="OMA" id="ENRMPFR"/>
    <dbReference type="OrthoDB" id="1427780at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="23077" checksum="60F7833363F9F2B6" modified="2011-10-19" version="1">MATLSCRPRMSRKLAVSGGLGSAQLSVRLYSSSVSGALRCTRVFTRPQTIKPNPAHTSSAKFDRSFEKLSSEIENRLPFRQQQILFGSKYDRNFGEESQDELRKAAAEDLFGQEPERAAARQARSYFTGDDLSPAALHVRSPRLKVAQLQHRQAYDKSILKTSREPSEYYYRRDTTVEHVARRRLLYALASGVGVVACWGLYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF94</accession>
    <name>F9WF94_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002117">
        <property type="protein sequence ID" value="CCD15962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13366" checksum="3CEEB7CFDDAFBB1F" modified="2011-10-19" version="1">MESNGTQQPCGPRLTVPNQVRKASKISAQVAGWVSNGPFGVVRRAKEEEGPTEGPPTYAAPHKSNTHLTRGGKAAQPPAGRSIQSNNSSKEIKSKQAEAKKSERKKKISAPHSSSFHHSHHTTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA5</accession>
    <name>F9WFA5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01160"/>
    <dbReference type="OrthoDB" id="1701620at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21778" checksum="C640BC39722DF28A" modified="2011-10-19" version="1">MTAHSMKGWPAGSRCRGDRRARFRLNWGKHTNLTELPRNTARSLCRWAALKNKSVHLAHHMWGACITGRRLHHTKADTAEGENRLPLQQVDISGLTLGWIRQPIEFAAGDRLDRVRDIKWHPTAAQTGGREFHSRISSTGAQLVKASTIETASIEKNTERWVVPFTAVEGNLPGRDALLFCAKPRTSRRIMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC6</accession>
    <name>F9WFC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 370</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002126">
        <property type="protein sequence ID" value="CCD15994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09660"/>
    <dbReference type="OrthoDB" id="1739580at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17021" checksum="9993BD3EE9A364D6" modified="2011-10-19" version="1">MTFSPAIAAHFPLIEWILVIVLLSLLGPILLVLGLCDAILEGWSVLGPCLVAYEHLAPCKRAFLNRRLAGLQRFGDTNAVGQLCVLEVLLQSFARWHALYGVIGQVVEGKGGGHDALPLLISFFPPVACYLRLYPSCLFFLLFPPCFVHGSNNWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC9</accession>
    <name>F9WFC9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 371</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002127">
        <property type="protein sequence ID" value="CCD15997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09690"/>
    <dbReference type="OMA" id="YDKYYQV"/>
    <dbReference type="OrthoDB" id="1432328at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="PTHR12866"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="31496" checksum="2A675B156B26ACEA" modified="2011-10-19" version="1">MNKQSLYEGFKKAYNSVVGVKTTKNFHETGTLTPSEFVEAGDELLHKMPVWSWAEGPEEIQPFLPPNKKYLIYRGAPCYERAAGGPGTGDETKESEDEDGWVTTHVNHVRKPLTEVVTEKTIDWDNSDDDSSDVDLDRAKPNEAEQRRCRLYDVYMTYDQYYQTPRIFLIGYAEDHVTPLTTSEMMEDVYPVNRERTVSIDPHPFLQAACISIHPCRHAETMRRMIQHMKRRVEEESKGADFVFPTHMALFLFLKFISSAVPSIEYDLSTGIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFT9</accession>
    <name>F9WFT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11190"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20039" checksum="B5D54FAD1BE03822" modified="2011-10-19" version="1">MARVGMEMIAPSKFVRMLPAWNKARWDEFPPFSDKLISQRMKRSVKGVDKLNEAVKKGVRQAAEKAIHKGNGVAPPFWTPDLTKLKVMVQQCRNERKRDARILWRSKVPVDTAIRLWEDNVSRPTVSDPISRNLVKSIDSILPLPSPVLVVDGDTLTKCRQHRHWHWQGCRRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFY1</accession>
    <name>F9WFY1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 436</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002199">
        <property type="protein sequence ID" value="CCD16211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11590"/>
    <dbReference type="OrthoDB" id="631249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="24751" checksum="C9255049C52AA186" modified="2011-10-19" version="1">MSFYFTHSRWNLQVLDLRDAHQDFWDGWAGLLHEVCSQDVFGKNQPVGNHPIPGGKQTISIKMNLSLKYCRRHSHCENLNYLYYWAKQRKDVIQVIFEKLEFTGKHCLRLKLWRLLKLSFVASIQELTIKSIHWDIYNLALIASCLGQMKNLQKLILMNIRRPSSLTDLQEARIITEIFSEFSKLHKLQHLYVNDVYFLKERLDLMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG56</accession>
    <name>F9WG56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 466</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_12300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SVP26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002233">
        <property type="protein sequence ID" value="CCD16290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12300"/>
    <dbReference type="OMA" id="FEDLPWS"/>
    <dbReference type="OrthoDB" id="1338610at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097020">
        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="PTHR13144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20219" checksum="27AFC8AA45961EC4" modified="2011-10-19" version="1">MTMTFGSHINDHNDRLEPLLMTLGPFRLATAAMACVVVGIVLFAIFCSINTISNLAEEYPTRAGKVLHAVVLCVMAVHVLVLLVEPLSYWCSLVSLVTNALYLRTLRHFPRVSFGKPFAMLLVTFFVVESMSWLCVLAASDKVLWEVGQSNAFLFIVMTWLAPVGLVLIADIEPICIGSLEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG78</accession>
    <name>F9WG78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002242">
        <property type="protein sequence ID" value="CCD16312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="13064" checksum="0B8A9E29AFD4440F" modified="2011-10-19" version="1">MHPINMPSSCNLKKRPSSPAGATIPFHPIQGLEVFSQSNPICISSALLWGFMHRTIIFGVVILFFHFSSFPLFIVRINKQRNHPTLAKERKCISVHRVSQNSGVQLSDLREQSTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB5</accession>
    <name>F9WGB5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 484</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_12870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002253">
        <property type="protein sequence ID" value="CCD16349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12870"/>
    <dbReference type="OrthoDB" id="1040311at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="369" mass="39882" checksum="282D4597D7212412" modified="2011-10-19" version="1">MGRRMRHFAGPGAQSGQLQTGAGGNEESGAVNELAFVEHTKDNAPMLYLPVDPTAAAAHLSRNCFTYCGPDAGADPQKRLHQEFKSLSKEERQRLVGERAVETDVIARTVHLRFLPTGMLQSELAALCAECGEYLRVRICGNSTTTQNWIYGFVEFADRAGAAAMMRRSGMELPNGPGKPPLRLKCNAAKQPIVDRVFHDADPETNMRCIFGSGNFAHRTLKEAVDSYYNLKRKEGTMGATQARSTNLSHSNNASGGWSNKHKKEGQNVSNNNNVNNNNHHNYQRCDSDGVEGIAGQPLHLADGHDWMLLTASSPLSAEGCHAHTNPVMGAGSPPKHQQVPSGCGYLASPGGTSVESPSFLSSLFHTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD5</accession>
    <name>F9WGD5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002260">
        <property type="protein sequence ID" value="CCD16369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13070"/>
    <dbReference type="OMA" id="DEKAPTH"/>
    <dbReference type="OrthoDB" id="382118at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="743" mass="75942" checksum="439DB796FA09852A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD9</accession>
    <name>F9WGD9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002263">
        <property type="protein sequence ID" value="CCD16374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16321" checksum="90808628CB06AEBA" modified="2011-10-19" version="1">MLWTSAGTENGNKHNFLCDGGRGYTEGGRKSRKDKPPGGVCVYYGSETKIWEENIDLLKQFKTALAIVDDANNKTATIQRDIDKLQTLLHRAEEIYETTQVISEIQKPVVPTNLQTAAKRLTTYNAARRYHPCHFILTWVPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGX0</accession>
    <name>F9WGX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002340">
        <property type="protein sequence ID" value="CCD16558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16112" checksum="F885E017162082A7" modified="2011-10-19" version="1">MNSASFRNILVNVRGRMSPCPSLVLAVFGSRRKISAPGFLKKNSFLGRSGAVSPYISFSISKVLDSSSTYCQHPELFPRRVAGFVLSFWQEQLLPTRRTAVVKALNYLVDSLYALPVASVPVGLVVEYLFAIGAANFSGSRSINRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGX9</accession>
    <name>F9WGX9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 569</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002347">
        <property type="protein sequence ID" value="CCD16567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14810"/>
    <dbReference type="OMA" id="KERMGNT"/>
    <dbReference type="OrthoDB" id="1149105at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="22584" checksum="097AEA2C0BC304D0" modified="2011-10-19" version="1">MSSEYDHLFKLLLIGDSGVGKSCLLLRFADDSYTESYISTIGVDFKIRTLNLDGKVIKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDTTDMESFNNVKSWLSEIDKFASESVNKLLVGNKCDLVTKKAVDTQMAQEFADSLGIPFLETSAKEAANVEKAFVEMAKNIKKRVAAQGASSGGAGSARPVLTGASRPANNTASQRGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH30</accession>
    <name>F9WH30_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 585</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_15280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002365">
        <property type="protein sequence ID" value="CCD16619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15280"/>
    <dbReference type="OrthoDB" id="1572585at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395045" evidence="2">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33871" checksum="B311DE8168A357A9" modified="2011-10-19" version="1">MRRTSLLLCSLLIALRSLCALGVELSTVYIQFGEYVTKDNKKLDGKGARALCILKRLVNSVSSRVMFLEGQTNAYLGKARSVFAEITGSDVLRDALGEEKLRKHGGVVKLMNMSQVNAANAAEESKLVASNASKLLSDVLQWHCVGRGNKHNSSSGYVLNGNCDPDAYRREFYYNGDVNDLEKHSIPCNYKAISSEETEPTYERMERALNFWDVTKPKPDPDFTPCTDEHFSDTKQREQVSCTVLENWLQGYNDAKKKVKKLENLVLMGVKMSKYAEELLGDAKKAAERAAGPPEPNLYPNGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH41</accession>
    <name>F9WH41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_15390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002371">
        <property type="protein sequence ID" value="CCD16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15390"/>
    <dbReference type="OrthoDB" id="368853at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="430" mass="47484" checksum="9257B9E853448714" modified="2011-10-19" version="1">MKRSSVPVSEETQLPRVYNDENDGGGEETATWSESDSLLVSCTVQTETESDGEDAGQQFNKTHDGDAATEVQSKHGLHGQCVFKPDNEKNDVSLPSDVTLSLISEEDYAATAPGEFPTLNLPAVTLTWEEVKMLGSDEESQESQEGVKCCRRYRLVSKDGKPWHSKDTTGSDLPTKFTCAFSIGRDDVPEQLGVVGKDGGKRSDVKYRETLSRKHCDVRFHFHSQKQSLKSGKAQRDTSNCTPFYRLTSYDVVDCSRNGTYCRHVRLFPAHRYSFPILRNSRTHQVELQFGYRYQCTINVSCEETSQITQYKGLAPTENVPTLSENVVEGKPSSPSVKTSSTQQPKEREMYTALSPSSAGERDFSLYGVLASKKKQNNTKGDIVTPAGGTSTASTSTSKPVSQKPVTIITTGFRLSRACLEKLRMIGGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH73</accession>
    <name>F9WH73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 607</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002389">
        <property type="protein sequence ID" value="CCD16662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15690"/>
    <dbReference type="OrthoDB" id="1691828at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29892" checksum="19CB392A5D96858B" modified="2011-10-19" version="1">MRTLLEGVSARVDTFQDITQKSLAEARERISHVSSNTHMQEALGKDRMNQTQQYSKMVDHIERRMKSECAISRSHATNASKTLSNVLENHCRADGGHHFRWESSANCDRAAGDIEPLSNRHHANGSGFSISCPPKAVAGYDTEPSFSAMETALRRWNHSKPVPNLTNVLECNDRGVSGSSRHTEPCTVLEAWLRDYEKTRYSIKRLYDITRTAMGMRRYAERLLNDGKQAIEQQKQRERELEEERARQQEAMQREAAAMKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHQ4</accession>
    <name>F9WHQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002475">
        <property type="protein sequence ID" value="CCD16848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01900"/>
    <dbReference type="OMA" id="RHTCGEE"/>
    <dbReference type="OrthoDB" id="1641134at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389151" evidence="2">
        <location>
            <begin position="31"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="462" mass="50578" checksum="E5C6E2F940F41011" modified="2011-10-19" version="1">MFSSLMWRMAPSRALLSTLLAPHAVTTAAAIVPTSRGLISRDASEENQGSSQFGEGGAITVSQRLPQPSRLYRHSLQPSPFLADVDVPMSSHITKSKEAHFPSGVAHEQDDKSNSKFHSSSAVSSNVLQTVEDPRVHIWRDEEKLLRVSVERLQAERELAEMRRGCEDELLALREGLKAREGQVERIVRRAKKESAARPFSLASATTTMTHAISGTGDWAVADFDKDAVDRLCDRYDAESDVFTLNEMSAEELKPKTRQRTCTSLQDSDDSGGDSVDAGDEDDFEMLVTAPVRRRGRRKAASTEVVSRPAKRGRKPSVATKESKGKGVKKRTPPASCNTTPRSGRKSGTGRASTSARRSAESGRGAVARVPRSKGPAKHQQHRKQREDKAASGRGRGRPRKTPAEKHQSPSSSKRRGANKAAEVVAMENPENAVARPRRGRPPKALMVTPAPQQWDLFAEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS3</accession>
    <name>F9WHS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 689</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002480">
        <property type="protein sequence ID" value="CCD16867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17520"/>
    <dbReference type="OMA" id="PCHISSM"/>
    <dbReference type="OrthoDB" id="1294194at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="31189" checksum="F0E8592EEE18E4B6" modified="2011-10-19" version="1">MTRGDRSQYGQSSRHRHRLSRDIDEVASDELEPRRRHRRHGHRRRKRTRERHWSARRGSYASSDGSVDSSDGRPTRRQRRREHSQDRSRPLHSTAALEKRPADWRKEMLSVLDEQLNAHCRSLGPSGNNKAALGSSASTGGDIGDVRTADDAPGAVAAPLKSSLGCVVLDGVDLGVQPCHINSMLEQLVGLRPLSVVRPAAQLWETIRSAAIDRITAATDDGVVGSDGKSVDLRSVTPEGCRHLGLHDASAAGGIVVLELSQASDVAAVVAALNGACLNGQFITACAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHZ6</accession>
    <name>F9WHZ6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_18230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002503">
        <property type="protein sequence ID" value="CCD16941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18230"/>
    <dbReference type="OMA" id="DQHQSMR"/>
    <dbReference type="OrthoDB" id="119789at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="9">
        <location>
            <begin position="525"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="691"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="863"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1194" mass="135719" checksum="1C751DB6F200CF72" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI49</accession>
    <name>F9WI49_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 732</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1705056at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390373" evidence="1">
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            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="23359" checksum="BDBB483C0F177254" modified="2011-10-19" version="1" fragment="single">MRIKAGSVWWIMAWGLIFCSEVLSASPYRRQGIPIEAGESICSLSKTLKEVVPWTQSQLEALKKTRDAYTSKFLEWLLHFNGSSECVVNEDNLETIRTNLENVNEEINKLPAKAIRAGALAAKSAGRLDEFITVFANAKKTGFIDGVNYCLGGGGEPARRRDLLDCFPDGEKLEMGESNLGKIPESMSNKKELNLAAALKSANHSVVGAYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
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    <name>F9WIC5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 766</fullName>
        </submittedName>
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        <name evidence="3" type="ORF">TCIL3000_0_19250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002566">
        <property type="protein sequence ID" value="CCD17072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19250"/>
    <dbReference type="OrthoDB" id="1575996at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="491" mass="54757" checksum="7682A678A9F150B9" modified="2011-10-19" version="1">MQNTSERYVPVIWKKKVVDINQQLDDDMRAAVRILKSGDMSTIESMLKGIDDVNWKCSDGNTLLHWAATLSNIYAVRVLLGVGADIDAVNAVGATPLHCATLCGSCETINELLLHGADPTIRNQRGHTVFDFMRDLWADTLYEEYEELERVLLGLDGDEQEADNILLSMGISSNYDLMTKRDLRKTVSMYVLRKRRELKKGAGEGDLSFNGEMALDEPAELSQPHLFGEKKKLHAEEAEKRNMIVSRYVEFLRDVSSNLRSVDFDITHVEESTHLCDKKPHLENNKCTADNPMVNQNGSGVWVKISDHCPCCQTHSNRDEDQKSTSARATVPDSARNFSSSLNGHSDVEDPQTILRCVMQLLQRATAPSSKCESGASAPSLPNISDSKNRRACAVRSMPVVPWKGGRVNESVTEVSVPTRFKGAPKGGQTRRWRITGRVSSLPAISRRRDDYRYYPPRVGSPKNTAVKGHENMSYATKKDPNPSTILPSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE1</accession>
    <name>F9WIE1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_19410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002574">
        <property type="protein sequence ID" value="CCD17088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19410"/>
    <dbReference type="OrthoDB" id="1673267at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390381" evidence="3">
        <location>
            <begin position="29"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="389" mass="43615" checksum="562ADA74293B3B4E" modified="2011-10-19" version="1">MWMREPRMIVKGTCMIMVLAMVVNLVHAYPPGTVFNDGEYKTLCPVFQASLDLWNATLNSEVKLSGGLKKALGQAIFGSASGGDMDSLKDELPKDYRNPGHRGRRCGLCRNKDSYFPGRSITHDIMCLCTPGKDAEPFYGYYWWFGYYYKANGFKLCGQLREEMGVDLSHGWYEEGTGKKANGLEKSWSAAVMGCVNSWRNSTKTANHSLEERLTKLKETLDIFTKKFFKDRNRWDKLGGFKEHSTESDGKDEKNIHVRYGPCGGSKTPWWKRLQDLLRKNTNEKLLIKPSAAMQAEGSEGEPEEQEDEESLEEAGDMESGEPTTQEGSSQQGPIENGTQTMTQSRTNSTTSVVNTTGVGNSTYPRLEYLRSSTTITRPLCLLSASFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIJ6</accession>
    <name>F9WIJ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 803</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_19910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002606">
        <property type="protein sequence ID" value="CCD17144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19910"/>
    <dbReference type="OrthoDB" id="1300278at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="PTHR12378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="3">
        <location>
            <begin position="44"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="667" mass="73398" checksum="6EBA5BA076C65687" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK1</accession>
    <name>F9WIK1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 805</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002608">
        <property type="protein sequence ID" value="CCD17149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19960"/>
    <dbReference type="OrthoDB" id="1778814at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="19517" checksum="CC07D77C18539BFA" modified="2011-10-19" version="1">MNFKQCVQNNVNNGNRVPTTAHARIFVRVTKEVHIHWYVFSLIISFLFFFIFFFLRGIFYFYYYLFCSHVVSRFLSFAVVREGSSGYGMCCNEKLKLCHFVFLFFFLFLYFCFYVWVRVCFSVLSLSVLLFSRVNSTITSQNERCTAHHVNLFLNMRKLFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIN1</accession>
    <name>F9WIN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002619">
        <property type="protein sequence ID" value="CCD17179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20240"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20130" checksum="730D705FB6353C68" modified="2011-10-19" version="1">MSTSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYPFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ73</accession>
    <name>F9WJ73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002693">
        <property type="protein sequence ID" value="CCD17377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1579717at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16748" checksum="EF127DE50A4EC318" modified="2011-10-19" version="1">MWANATWEQRASILRKLCEFSEQNHLGAREENVPSFFESLQLTKSSGVQYTRTLLGLLEAGRTPAQMSLAVLQQRAVNVPMKQARPMENWKLALMSNTPSFKCGRVALCLARAALGRPDEIALFQEENFISHQAVARQLFRELKTTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJN9</accession>
    <name>F9WJN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 933</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002750">
        <property type="protein sequence ID" value="CCD17546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23600"/>
    <dbReference type="OMA" id="PQAINDE"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17371" checksum="ABEBC8803F197472" modified="2011-10-19" version="1">MILWPEGANLVIRNTHHYTPSLNIYNRVKYLSTIWVRGPVLRIDMKASFYQIPLTERAARRLAFWAGDAISGAWYAFKRLPMGHTLSLEIMQIAMSTLMGDERFTALPESVKPFIVDTWLDDARIIASSPADLQRIGELIRERIHQCKATVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJW7</accession>
    <name>F9WJW7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 961</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002782">
        <property type="protein sequence ID" value="CCD17625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24310"/>
    <dbReference type="OrthoDB" id="1724620at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041417">
        <property type="entry name" value="NPEPL1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18295">
        <property type="entry name" value="Pdase_M17_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pdase_M17_N2" evidence="1">
        <location>
            <begin position="56"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16756" checksum="72272BED678125C3" modified="2011-10-19" version="1" fragment="single">MQSYKRQRTESSYEERNVTSFVDSCVNFVSNLTFHTTAEGKEFAESLKSGSTQGLHTILLLGTEEQMKAKNLNDFFPYATPEFDEALKHAENIGFETTCCRFGSNRNIAVALGTVSATASRHNCPWRPDQITSVVKEAVKYARRTTAGGCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK65</accession>
    <name>F9WK65_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_25100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01002816">
        <property type="protein sequence ID" value="CCD17726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25100"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="1065556at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="66"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD17726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="478" mass="52741" checksum="FF0FBB5E1A6F4E55" modified="2011-10-19" version="1">MSKGADGAALLAEIQQLRQLLSEKEALLSGDGEGSITKKPKKKSQKDMVETEPVQGCRDFPPEAMRLRRYLFGVFHETARKFGFEEYDSPVLESEELYIRKAGEEITEQMFNFVTKGGHRVALRPEMTPSLARQLLAKGRSLLLPAKWYSIPQCWRYETITRGRRREHYQWNMDIVGVRSISSEVELVCAACSAMQSLGLTSKDVGIKINSRKVLQTVVEQAGVAADKFAPVCVIVDKMDKLPREEVIAQLATIGLESDVVNAITSALSLKTIDEIAQCIGEGHEAVQELKDFLAQVEGYGFGDWVVFDASVVRGLAYYTGIVFEGFDREGKFRAVCGGGRYDNLLTTYGSPTPVPCAGFGFGDCVIVELLNEKKLLPELSHAVDDIVIPFDEGMRLHALSVLRRLRDAGRSADIVLDKKKMTQAFNYADRIGATRAVLVAPDEWANGEVRVKMLREGAGKGEGATERGVVVPIGEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G1</accession>
    <name>F9W3G1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1049</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000406">
        <property type="protein sequence ID" value="CCD11677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26370"/>
    <dbReference type="OrthoDB" id="1668504at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388624" evidence="1">
        <location>
            <begin position="27"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="43566" checksum="D9B59671BB062D11" modified="2011-10-19" version="1">MIIRMEPGSVWWIMVVIFVEVSPISSQSSYYPKAIPTEAGGAICTLSRKLKDVTPWAVGQVSELKKTRDDYESKFLDWKLHFNGNSECGENETILDEILTTLERVNEEIHALPSKAIHAGALAAKSAGRLDEFITVFSNAEKSSTSIFEKTSGSASRYCLGGGGNAAKRRNLFDCFPTGGKIEMGENNLARIPENAPHKEEPNLIDAIKNINHSAITGYVKRYDGDENAGCNLISGKAGIIGSELEDGFWWGGGILTIGKGFEGELKGEKFGPGEIGNAIGGEESSKAFWTGSPSTIQHLNKTLAAFQAFKDATSRITQKFSKIEKIEKQIEPCLSNETMEEGPTQSCFRSAVKLNAELQAANALLARYHKEKGPLPSGSSLILHQRVVNFWLPFAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G3</accession>
    <name>F9W3G3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000407">
        <property type="protein sequence ID" value="CCD11680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26390"/>
    <dbReference type="OrthoDB" id="1700319at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="25514" checksum="C5E128ED975BA1A4" modified="2011-10-19" version="1">MPSSDVNEESNSGISSGSQQHVGEGGRPTGPDPSCNPLRVTAHVMRAVGRIEKIVEKAEARNEGPGLEEREQLQRLMDDIETLCAEGPEGTQGGEGMKRWIEEIQGRFGKLNDEFLRLGEQIEAKEQESHIELRGELNRTVGGKERDTQAEVQGSRPAAQEGFRLPPIKGQLMKQQENLQKDKRMKKTADEVASRPPRLAIMTEAQREVELTIKYLEWALAELSKVSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3N8</accession>
    <name>F9W3N8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1083</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000444">
        <property type="protein sequence ID" value="CCD11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27090"/>
    <dbReference type="OMA" id="GNNTECH"/>
    <dbReference type="OrthoDB" id="1430114at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="SSF143503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="3"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="37800" checksum="2D866ED5CDA82961" modified="2011-10-19" version="1" fragment="single">RLGAYDILETIVRNILRFSEEQKYRRLRRSNERLQSQLFSVPGAIEFLDSLGFVNSEGEAGNPEGECLVLPKTASRELLDQGLEAINFLRCRDREGSGRAPNYLRMRQALRLEVRRERCEKAKAVGELHSYICQEFSADDAGDGLYTSLTNIDTLHTILTNIISHPNEEKYRRLRLGNNAVYKCVLQQRGALELLLECAGGELVEESGEKTALLFPREAGVSEDRLRYALRVLEEVKNAVHTVKEEIRHREYEEAKKAMRSEVLYTKMLESRQPCHGNNTECHQALGSAERDESQAAEEEKKKHPRKGQRIPIKEAVRILMGKVETDYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3N9</accession>
    <name>F9W3N9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1084</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27090a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000445">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="20" mass="2384" checksum="359D727321DAC22B" modified="2011-10-19" version="1" fragment="single">MDFDSLKEDLSHHEKTNSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3T5</accession>
    <name>F9W3T5_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1106</fullName>
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        <name evidence="2" type="ORF">TCIL3000_0_27530</name>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="DKCIVSY"/>
    <dbReference type="OrthoDB" id="1653539at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="1533"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1533" mass="159570" checksum="E6B3D6C2FED9D6AB" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3W7</accession>
    <name>F9W3W7_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1119</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TCIL3000_0_27850</name>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000484">
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    <dbReference type="OrthoDB" id="1724300at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17617" checksum="0D4596EB6969A37F" modified="2011-10-19" version="1">MRVGAAVLWHSGWCCHFIRMGISSLSTLIPFLSFLIRALLRCVAEWPQALGGFCGRFIALLAKRSRFHLTPTSEGPSVKGGAKLLASHRLGVWSGSIGQLISHWAFFLLTLFLIVFIDPKGIIPHGRSGGNASTQIASRGMVLWRSALERNPLPTKVPLGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y8</accession>
    <name>F9W3Y8_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1128</fullName>
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        <name evidence="2" type="ORF">TCIL3000_0_28050</name>
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    <organism evidence="2 3">
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000495">
        <property type="protein sequence ID" value="CCD11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28050"/>
    <dbReference type="OMA" id="RFRHYID"/>
    <dbReference type="OrthoDB" id="368863at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="35"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="659" mass="73367" checksum="80FB1D0105D286C8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>F9W403</accession>
    <name>F9W403_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
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        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TCIL3000_0_28240</name>
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    <organism evidence="13 14">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL3000</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01000500">
        <property type="protein sequence ID" value="CCD11886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28240"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="528822at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1e" evidence="12">
        <location>
            <begin position="44"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="656"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD11886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="772" mass="88307" checksum="15C6B6CC79D22344" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W407</accession>
    <name>F9W407_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000500">
        <property type="protein sequence ID" value="CCD11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28280"/>
    <dbReference type="OrthoDB" id="1718123at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19010" checksum="9F3D027FE2A3A729" modified="2011-10-19" version="1">MAGNMEECGATVGEYQQMVERCEFAGILFGHDMQAVWQSEMAQQLRDSFPLEGATIEQMDRVASRIIYAGPGFVWERLLLSCYFPLKVARWRLSRLNIGLACPSDPSALSRKALILSKVCVCEHVVKKHTSGPNTSPASHGRSGCGRFHAWLWSDVILRFGRNFNSGRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W414</accession>
    <name>F9W414_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000502">
        <property type="protein sequence ID" value="CCD11897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28350"/>
    <dbReference type="OMA" id="IKLANDW"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="732" mass="83924" checksum="460D0870405FB8E4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W418</accession>
    <name>F9W418_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_28390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000504">
        <property type="protein sequence ID" value="CCD11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28390"/>
    <dbReference type="OMA" id="PKTHFRY"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39820" checksum="687C03EDAB6125D0" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYRDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGRPPMTVDWRKKGAVTPVKDQGKCDSSWAFSAIGNIEGQWKIAGHELTSLSEQMLVSCDTDDFGCRGGFSDPAFKWILWSNKGNVFTEQSYPYASGGGNVPTCKMSGKVVGAKISNRLYLPEDEDMITEWLARKGPVAIAVDATSFQSYTGGVLTSCISKEMNYGALLVGYDDTSKPPYWIIKNSWSKGWGEEGYIRIEKGTNQCLVKNLPSSAVVSGPPPPPTAPTFTQELCEGAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W424</accession>
    <name>F9W424_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000507">
        <property type="protein sequence ID" value="CCD11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28430"/>
    <dbReference type="OrthoDB" id="1701650at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="24362" checksum="F9562260C697AEF2" modified="2011-10-19" version="1">MCLIKMGVAEEAMRDEIIFLCTAVGRWKEPANDGIRRAAAGVVRVKAEFEHLKVVIRLAGRMDEIENSSKLIQDQVKVWVSSGVGDEKVNEIKRSVITMKNDLLEFATVVQEEKFFWREELIERLSDTARGNVEDMEQLCLMSFQMLENNGGAMELGNVRRMYVDRQRGTKVFVEACEEVVVNLTAVGERTQVLIAMFDEVMNQWPMDPDNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W430</accession>
    <name>F9W430_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1140</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_28490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000508">
        <property type="protein sequence ID" value="CCD11913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28490"/>
    <dbReference type="OMA" id="IMANAPS"/>
    <dbReference type="OrthoDB" id="1036235at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="Mitochondrial_sb/sol_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="Mt_carrier_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="SSF103506"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD11913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="322" mass="35670" checksum="FB9661628D69D147" modified="2011-10-19" version="1">MNAAVYRTLVSASYLFWQDSMRIFIERYLPTCLHSSNSPSINAFMIGALAGSLNGSLLNGFQVVKYRMWSAENNLSFFVVTWNLYREKGVFIFFRGIAATTLRDCIFGVVYEMCRKSSWVQSTFQLLSHCVSEDAGCLRTPCGSHGSSKVDLAVHNTNTLPPSDTHRDLEGHSTVRNNGTGLSSNVVFVSNLFAAMLASVLSSPFNYVRSVAYGVPLGSGPVSYLRLLQSLYIQTLFVYRNGKIYGHANATAKNVGEPVTASRGQLWCYLEGRAARRGRHPMAAIRWMNSRLNIGWGSVRVGLGMAISQSVFASIQDRIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4C8</accession>
    <name>F9W4C8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000541">
        <property type="protein sequence ID" value="CCD12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29390"/>
    <dbReference type="OrthoDB" id="1657752at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="629" mass="68534" checksum="47FA8E37AD020042" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4D7</accession>
    <name>F9W4D7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_29480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000545">
        <property type="protein sequence ID" value="CCD12028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29480"/>
    <dbReference type="OrthoDB" id="1672191at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389785" evidence="10">
        <location>
            <begin position="27"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD12028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="42322" checksum="CA90415FFC45E328" modified="2011-10-19" version="1">MLTEPRVAWWLFLASVILLFSDVALGTGPKAIPTKAGAAICTLSKTLKDVTPWATQQVEDGAAKITNLEMKLLEWQSKFIQSKSKGSGSEACKITGLLFRQVRKEINKARAEVEKLEKEASKAAAFTANSAGRLDEFITVFANAKGGDNNYCLGGTKAATAGDLKDCFSGTDFGEESLVDIGEKASEQEPGLFSAIEGIKHSALSPHFTAGSSGGCNLIKGSSGGILKSVGLEKSLWWGGGILTIGKAFGGEFSSSFGPGEIANDTKDGKHALWTADPAQRIVHLKNASDAFKAFKAVQEKIKSKVESIEQKIQACIGGQESGENSTEQNTTEHTATTEQTTTSPTCFDNVAKIAADLKEKRALLARYQKLKGWIPPNSAFNARKATRHFGILLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S5</accession>
    <name>F9W4S5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000598">
        <property type="protein sequence ID" value="CCD12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30790"/>
    <dbReference type="OrthoDB" id="1713658at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18733" checksum="ECC43C701E7FE727" modified="2011-10-19" version="1">MKRVLAPRVLNRQEGSVLKLETTRMQGWPLARGYMPCNPCPNPQLFERVAGMRKGSISGSSWRCIEKKNPWGVPSSPLAMQELGPERTTCGRRILSSSGRKYLSQLFHICLRLHRTPRHYLRDNMPPFPELVKSLSDTSVLHPSLIMNTRLEFMNCMAARRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W538</accession>
    <name>F9W538_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1272</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000654">
        <property type="protein sequence ID" value="CCD12285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31820"/>
    <dbReference type="OrthoDB" id="1725621at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="17783" checksum="A6F74BCC6179CB8E" modified="2011-10-19" version="1">MPVPAASLKHLSDPGRPRRIQPSLLGHAPIDSGSVKSVDLAAGSGVQVIVTFGVSAAYEGKEEGREKRGGWREDSILDGVLQDKLGNCFYPGILLPFHLLLQRLNAAPGQIPNDREHAHPQPGHQAVELLNHFFPRELIPNTTLGSWRKSPTVKRATFFLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5F9</accession>
    <name>F9W5F9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_32910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32910"/>
    <dbReference type="OrthoDB" id="1528896at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="205" mass="22865" checksum="5989F2D19675ABC7" modified="2011-10-19" version="1">MRNFDRVLLDAPCTGTGIISRDKSIKTSKQYEDVQRASQLQRALLLSAIDALRVGGYLVYSTCSFLVEENEAVVDFALHRRDVTIVETGLPFGRPGLAKYRHHRFNDKLQHARRLFPHVHNMDGFFVCKLKKLSNEANGAKVPLEEDDNNERGTRKGGAVKGSVRGKRPREGGDVQKGAKATERRSRISVPPPTKKVTNIKAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G2</accession>
    <name>F9W5G2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TCIL3000_0_32940</name>
        <name evidence="18" type="ORF">TCIL3000_4_3350</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">IL3000</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="HE575317">
        <property type="protein sequence ID" value="CCC90234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_4_3350"/>
    <dbReference type="OMA" id="RDLHGTH"/>
    <dbReference type="OrthoDB" id="42570at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="14">
        <location>
            <begin position="51"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="13">
        <location>
            <begin position="274"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="15">
        <location>
            <begin position="481"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_4" evidence="16">
        <location>
            <begin position="581"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_5" evidence="17">
        <location>
            <begin position="671"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="11">
        <location>
            <begin position="720"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="12">
        <location>
            <begin position="1092"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CCC90234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CCD12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1186" mass="133918" checksum="4E5E6F1E349D4CD3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W636</accession>
    <name>F9W636_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000819">
        <property type="protein sequence ID" value="CCD12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="16204" checksum="C9FEA7283D3F7D6D" modified="2011-10-19" version="1">MVRSLRRYFIYLCEIVVSICLFTFPAFVSFFFFFLSYYYRNYSPSSCMGAFSAYDSTVKEGSNSQQNRSEKYLRRFSHGGCLWRGHGTLGKRYRLGKGITTLPALPVCPRYSIVLYFRSFYYCVFPFVFLMFVSPYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W689</accession>
    <name>F9W689_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1437</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_35530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000837">
        <property type="protein sequence ID" value="CCD12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35530"/>
    <dbReference type="OMA" id="HWEDSKE"/>
    <dbReference type="OrthoDB" id="1670013at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388721" evidence="2">
        <location>
            <begin position="25"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="631" mass="73302" checksum="BBB7D0226A588679" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I7</accession>
    <name>F9W6I7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1475</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000879">
        <property type="protein sequence ID" value="CCD12792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36430"/>
    <dbReference type="OMA" id="LPRCNGH"/>
    <dbReference type="OrthoDB" id="412845at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="504" mass="58201" checksum="ED81A33264E3FBE7" modified="2011-10-19" version="1">MFLKKTMSGVRDLSTGRPVSRILMEWFVEEVSPKSFTFEVVVEEAYRRANINVSKSVCSLPDSELWRKLCNACGNKVSTSRYGMSMLRQRLVRAMAERLAIEEIFRLNKHEIEKESIDEPLVVLGLPRCNGHQAAHVLSRSGLFLAFRQADTMFPSLLLELERRDAFRSELKFFKYLYPDFRCVRRIDPVQIDDDLTLQLMCPQSYAWGLLHGLDEYLLECLQADQTPVYRHIRRVCQVFQWYKRCGHFSECILDEVNPIDNIVEEQKYGTKEPLKRTRWLLFSPLAILNVASLCDVFPDMRVIWVHRALSQCIPSLCSSLSIHNSIYTGKAPSDTQLVTMGDKVLGVFGSGTEHAIDYFASFEKSRMVHWSNRDLKRHSVRLAAKTLKYYGVEIDRYRRMEMINGQTEYTDAFRPLHDCQMPYFGLHEGIIGEAFERYIYQFEEFAFEPKFGITVEEYQPLAAAADQQSLGSLRVSGDGSNLPTFTENQPMSGHFLQEGKGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J3</accession>
    <name>F9W6J3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_36480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000886">
        <property type="protein sequence ID" value="CCD12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36480"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="47"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="252"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="312" mass="35382" checksum="9AC060C3928BAFCB" modified="2011-10-19" version="1">MHGPVYVYDEDKDKETLKVMQVLHNATTKNMKEFQKTLWDMKDIFQEHSLPTRPENWEKAHKKMGYFVKETEMEVDKNRNLAKQVNEKIEAAKLLLAQGIYGDHVMELPKNDGNYMKVLENTSSIFNDENSPSQSCGNTQEKAGKTLINDLFCVCVGDADDAQGPCHPNIWPPKSWGYTGSTGNWTQIKYGPDYPTLIPSFNESLHIMEQVCWENMTENNVKSENITALLEQYVSLIGKGNGGVKQNKNIFGHSTRSKNRGQVKECDGQQGNWHHNGPEKKTIKPASTTLTIYKAKNTTSPGTINLEKLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6K3</accession>
    <name>F9W6K3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_5_3480</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36580</name>
        <name evidence="1" type="ORF">TCIL3000_5_3480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000889">
        <property type="protein sequence ID" value="CCD12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36580"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_3480"/>
    <dbReference type="OMA" id="KWSRQLR"/>
    <dbReference type="OrthoDB" id="1076998at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC90617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="24072" checksum="3A8EB4EDD3BB58FB" modified="2011-10-19" version="1">MLQRLSVRRMWLGGTASGTALGHDVRPSTGKYINVVGPTDVAANIAAGTMPPEASVAAALPMPHTPYGKWNRALRSDVYDELLKLPLRYKLHDFTKLCPQRHEQSAGPVGIVGGSSAVGYLPPLGPADPLDTIPFFVHRNSNGFLPGKVYSMNARNLMPAFYLRIQQVEGDMFRFEEELLKIFPTKKIFVRSHSIYVYNVALDGRMVLHHWLLGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6M6</accession>
    <name>F9W6M6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1708222at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="111" mass="13145" checksum="116BE68E8D1D73ED" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMERDVVDVLLEGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEVNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6S7</accession>
    <name>F9W6S7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1518</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_37230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000927">
        <property type="protein sequence ID" value="CCD12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37230"/>
    <dbReference type="OMA" id="CENGEAW"/>
    <dbReference type="OrthoDB" id="838525at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="427" mass="47244" checksum="353E3F750A4C2913" modified="2011-10-19" version="1">MVRYVLVDEMKNTTIPLEVGKNLVRRHTTQVKKDASVVLLDPAYRNVSRTHAVIDVWENGDVWLQDCKSTNGTYFCGQTGNAERLQPGHCYQLKPRNYVIFADVRLRFDVEVAPVCKSHDTNNKTATWEGCPPEPVPPTPQSAQPDSTRNTSSDNHCATNWANPFSPVSTVYNLSASLPTSRNTDQCNIVLMRQGSPSTWAPSLILSVASAPLTADITPRMKRCRENHGNDLLRSDTKGNEVPPTTAVEEGVETRRQRRRAFHVCFSGIMPQKVCIASSEVVSRGWKVVDDIRRANLLVVGIPATRTPKFLIAVGRGIPIVTEAFLYCGGESCFRSFVPTLTHNGHTFEAHELHEVILKNKTKPALKGMTYSLGLLPIDARATAEMILTFCGARITSKGVCRKGTVQLTRDSLHSLYDGMLRGDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U0</accession>
    <name>F9W6U0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000936">
        <property type="protein sequence ID" value="CCD12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37350"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="17977" checksum="61D664EF7EB9174A" modified="2011-10-19" version="1">MRHISWRVLSPKEAGGRRARAPRRVGAPSQIPPDMRSNTAHGSFEKHAHVSSEIHTLPPTDTHGGDLPLASFTPAVAAHNACQPAFPKTSARVSRVRSSAAGFSPNTITGWQALTSRECGRHCPEACSSSNTSPAISQSPRRLARRHGGSTHGTLASEFAFNQLNSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W726</accession>
    <name>F9W726_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000969">
        <property type="protein sequence ID" value="CCD12985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38030"/>
    <dbReference type="OrthoDB" id="1698791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394728" evidence="1">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="231" mass="27058" checksum="1D7AA6CD0718EB87" modified="2011-10-19" version="1">MGKMMKLFMVMVVVLCVCASADEKHVHRSAVYLFFPIPISPFPETSIEIPMSFNTFHSPRRRPWSMEKDVLDVLLDGVASADRINLYWFLRPVLACLPVDLVIFTLRDFVRNPRHCIPAANVCDALWQYLPYILWKFRQSATPLVKHFGPTQTWTKWHWDPWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPYQEVVVVEAAPAFIQVPYPTVGYLVHLPVTPRAWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7A7</accession>
    <name>F9W7A7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14385" checksum="36F049886C11CFBE" modified="2011-10-19" version="1">MEGPASASAVPRGCADLHSAKLREESVCAPTSQAVSEGLDRVKPNRRRASGRVRDLGDLPLAEFLLEECDFPVRDSARPRGSLYDLLENPTQHLRDEEARERVLQEMQAQLADRKARARVMGRSCMRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7A8</accession>
    <name>F9W7A8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03980"/>
    <dbReference type="OrthoDB" id="1706218at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="213" mass="24369" checksum="E7630C686A2F7093" modified="2011-10-19" version="1">MVLEKKGMWFWMVMVVGVGTGTASWDMRKSHHHHELADLCEVLGAAVVLYNRGATGAGLWKALGQVIFWKHAGGNWEYLQKGFPQKYGKECARTNSLGKCLYNNHAHNPRKVHPTRPSLQVYGERKWIPVPTSRRQDSPTLCGRTAAEWEGGSNRKDGGWGHNGNKHGWNESSDHRKRTRKHLDTTWDKVVKTCPRRRQTLLQNRHESLGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7J0</accession>
    <name>F9W7J0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001042">
        <property type="protein sequence ID" value="CCD13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11194" checksum="2EF4DCD0257D82F7" modified="2011-10-19" version="1">MSSQENMDAYNKGTEAWRNPNILCARQQTRRAGGGNYGFPFYGTYTTCKEQRKSVHEDAAFDVGYRAYTGADVVSGTFQIGTMRSHEAGMFHAALGARSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7J8</accession>
    <name>F9W7J8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001044">
        <property type="protein sequence ID" value="CCD13165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04310"/>
    <dbReference type="OrthoDB" id="1715948at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17452" checksum="79458159E8E5287B" modified="2011-10-19" version="1">MGMNMWSGGWSRYPGHSVAVNIPCASRPGLKKLREGITTSLAQRGWSGLYDLYRGDWKKEESWYVDVAKSHYSAGLFKKVWERVVKKCGNEANVSSECSVTAMQEALDKFKEYAKENRCQLGSPVGGLVTGCTPRCLHILQKLRWPGRYSLCQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N2</accession>
    <name>F9W7N2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001058">
        <property type="protein sequence ID" value="CCD13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="106" mass="12048" checksum="5882D0FAD68DB10D" modified="2011-10-19" version="1">MNEAICYMSCIVVRASSVKFVDLCAVWSSWVWRVPSHSHIFSAGTRLVALYSTGAPRGVPIYLPFVVQFVLGSFQLLLLHSYGLCFTFVSVNCFGPHSVRYYWKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7U1</accession>
    <name>F9W7U1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001080">
        <property type="protein sequence ID" value="CCD13263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40320"/>
    <dbReference type="OrthoDB" id="1698207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25171" checksum="B4F24993C20C3E95" modified="2011-10-19" version="1">MQQNSSTIRKTCPQCCLPYDHSFFSPILAFSIRIPMSFYTITSPRTIPWSMEKDVVDVLLDGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEANVCDAIWQYLPYLLWKFRQSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIHEEIWRRCRCPPPPPYQPCQEVVVVQAAPALIQVPYSTVGYLVPIPVSPRPWCGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7U5</accession>
    <name>F9W7U5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1655</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 614</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_15830</name>
        <name evidence="2" type="ORF">TCIL3000_0_40360</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001081">
        <property type="protein sequence ID" value="CCD13267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002396">
        <property type="protein sequence ID" value="CCD16676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15830"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40360"/>
    <dbReference type="OMA" id="AEFYETT"/>
    <dbReference type="OrthoDB" id="1222469at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22795" checksum="D32E955D65AA4DE7" modified="2011-10-19" version="1">MGKRNQKKANGAGVYWVRAAVILLIIYVAKLTISYCSSVYYDREALYQGALNCSLQVLRKHGVDHWLQNGTLLGSTRLGRLVLWDADLDIGFVRSESNEKHGALLQDLDSVCFGPRSDFILGAKYPLKIYRKCNERICAEFYEALVKDGSVITSDGISSQRELFPLKNCTVANIIAQCPHNSSFYLKEAYGNEWLTASLLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Y8</accession>
    <name>F9W7Y8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1678</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001106">
        <property type="protein sequence ID" value="CCD13311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40775"/>
    <dbReference type="OrthoDB" id="1731200at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="18534" checksum="69BA58D426B98A11" modified="2011-10-19" version="1">MWPTYQSSLYMVLFHSIFTPPRKTTVCDKMIVEGFCIQEQMIMMMIFNAMNMSPHEIIRKNMFKGIFLLLWWRFWHIKSLTPHAPLLPRYLNNNNKNDNDKQCMQSFPIVFMYNPRNKCTIILYGCGLLSDLDSFSGICLLFFGYELYFIVCVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W805</accession>
    <name>F9W805_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001115">
        <property type="protein sequence ID" value="CCD13329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40920"/>
    <dbReference type="OrthoDB" id="1692357at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="16639" checksum="E98E6C35D9760684" modified="2011-10-19" version="1">MANTSDSQRXDAGLPAVTCSAAIKSGSDAQGNDVILDNKRNIGTPTSEISESIPMFLNMTKGSKCNSVLLSGSASVCRGIASEKGDIAITCSPKDAFETLIAKVDSFVGSSKENKTVSSLNATSVSSTPSVGGDSDQRHSDSSLYSSLSSRRLSGTRSGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W810</accession>
    <name>F9W810_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_40970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001118">
        <property type="protein sequence ID" value="CCD13334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="13700" checksum="87BBCC7DF5D1021D" modified="2011-10-19" version="1">MEPNAGGALNEEAARLLLEDYEAYRRKANMMTKVHAMKSGRVGNEEAGPIAVNGALESTEGGLSCGENDNHDSGKSNTGKLANNGTGGGLRLSLNTNNVDNKGVPGDLPPASAAAAAASKKAVEKKRAALRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W857</accession>
    <name>F9W857_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001139">
        <property type="protein sequence ID" value="CCD13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16179" checksum="C639323D9230D5E5" modified="2011-10-19" version="1">MQERIQLVIFPPLDSDKVSRAEFGWEKLYRAGLRWAGCGEGWREEKLKKTYGLLVAILLMVVGVTVWELRLRSQAAMGNKMTLIGNAHTSMQLKVKEGRLRLICPFHKSGAPASSPDGTYKLTVSFSVPSCKSVLKPTSVLDTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8P1</accession>
    <name>F9W8P1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1756</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001193">
        <property type="protein sequence ID" value="CCD13576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43180"/>
    <dbReference type="OrthoDB" id="1731805at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394612" evidence="2">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="19001" checksum="BE1388FC1C1E500B" modified="2011-10-19" version="1">MRARTSALLISVLSSFSALFPHVPASFAKDASLLTGGLLQWVPHVACLVAPFLDLPHLTHPIPAAHTLQFPLEHGKPHVPATLSSPPLLSAAASSAASSAAMHGGSSGSVAPPCLPIRCRSMLAHALSSHLHTRHANSPLAFGPRPLEDRGCPSPPPPPQLTFLSVLGVSLATAIPTTGTPQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8P2</accession>
    <name>F9W8P2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001193">
        <property type="protein sequence ID" value="CCD13577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43190"/>
    <dbReference type="OrthoDB" id="1729042at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15759" checksum="673FA4B3AC2F59AC" modified="2011-10-19" version="1">MIYFSFYSNQSGKFKPFQYKTEPLMVSALFPFIASAAICWCAFTLSCTFRYNVVGSFFPLTSNVLTGACFIHTASPSKQTDKYPSSSNKCRPYGSHISVPFTRAHPFRYAPHSQLPVKLLLPMDGSAMRLDKWCVALTFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Q2</accession>
    <name>F9W8Q2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1759</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_43290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001196">
        <property type="protein sequence ID" value="CCD13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43290"/>
    <dbReference type="OMA" id="THGYDIH"/>
    <dbReference type="OrthoDB" id="593224at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021067">
        <property type="entry name" value="Glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34496">
        <property type="entry name" value="PTHR34496"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11397">
        <property type="entry name" value="GlcNAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="782" mass="88710" checksum="5149CB4F39E4DAD6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8V2</accession>
    <name>F9W8V2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1783</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_43760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001223">
        <property type="protein sequence ID" value="CCD13638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43760"/>
    <dbReference type="OMA" id="NCPLCWA"/>
    <dbReference type="OrthoDB" id="350086at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="418"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="535" mass="59861" checksum="93BD785B20ACFFBC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W910</accession>
    <name>F9W910_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001253">
        <property type="protein sequence ID" value="CCD13699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="13898" checksum="4E4620583617A520" modified="2011-10-19" version="1">MYCTDRTIETARGRNHKRKKKKSMASIDYQQSFPPHTPTHPIHLHCFLYSMLSTADATCSFCTIGVHDPNTLNSVGGEAEKSSLGDKTPVSNLAPGCPSDRHVDTDIAEPGGGKPPGTAALLCCSASLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9B4</accession>
    <name>F9W9B4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001291">
        <property type="protein sequence ID" value="CCD13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45060"/>
    <dbReference type="OrthoDB" id="1701327at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21341" checksum="ECEDD1670E555ADC" modified="2011-10-19" version="1">MSFYTITSPRTIPWSMEKDVLEVLLDGVTSADHVNLYWFLRPVLAGLTVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQSQPYQGVVLVEAAPAFIQVPYSTVGYLVQMPLFPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9E6</accession>
    <name>F9W9E6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1854</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001302">
        <property type="protein sequence ID" value="CCD13846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45370"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1322992at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="250" mass="27186" checksum="5FA4E419BCE42C03" modified="2011-10-19" version="1">MVLQHIGLLRQKRIVLASASPRRLEILRILGLDNVLVFPSNVAEDLPKADFKCGGDYALCTARLKAERAIKQQLEVRDNTGEEPRRDSGNRPSLDILIAADTVVTLPSVDGKRGIDIIEKAATAEEAAAMMRRLSGRRHDVWSGVVIAVVPPGSANSANDVHWHEMKVHTSVEFAMLSEDEITAYVANQNNWRGKAGAYGIQDTAACMIRSIEGDYYNVMGLPLHAVCAAFDTLISNGLIAPSGGRDDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K1</accession>
    <name>F9W9K1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45930"/>
    <dbReference type="OrthoDB" id="1750125at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="21709" checksum="94B379D4B01AF093" modified="2011-10-19" version="1">MTTRHRGHMATLVFCGKMSTLRHWTHVTLNCRMGVTAAQSGQRTDGAPIGYASVTWQPWQAICPVQYRSGGMNQLLLPCYATCNVCIYICVCVVCVTCACSLFALLQIPLKLLSRDPFYSFLLSKFLLFFTFPGIVLVSHNLRVSSLLVVSVRLFEWLVAFPPPIRIPTSHVRKRRREEKKMGKNEKQKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Y8</accession>
    <name>F9W9Y8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001364">
        <property type="protein sequence ID" value="CCD14043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47230"/>
    <dbReference type="OMA" id="GPRWQQF"/>
    <dbReference type="OrthoDB" id="1430018at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="117"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="334" mass="37571" checksum="6D73461053BC95E5" modified="2011-10-19" version="1">MMIWLRNIISNVLHELANAVKRTPLFIWIYLSIVAYAARKLTYHYGYTRRKMLVRGRVIYVSSAEEGLVGDIVNFEDIDTSFGDIGGLDDVKTALIEHVKWPFTRPELFEGNTLRSHPKGILLYGPPGTGKTLLARSLAKELGCTFINVKSESLFSKWVGDTERNSAAVFTLAEKLSPCVIFIDEIDALLGTRTSMDAAHHTNTKTTFMTNWDGIIQSKSKIVVIGATNRPLSIDDAIRRRLPLQLEVPPPAASERKKILDILLRHDVQDKTARDRLIDYIASRTANCTGSDLTELCKAAALIPIRELREDGRIPSLERRHFEEAFKRVRPSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Z6</accession>
    <name>F9W9Z6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001367">
        <property type="protein sequence ID" value="CCD14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00490"/>
    <dbReference type="OrthoDB" id="1676707at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="36980" checksum="63DCBECDA83CDDFE" modified="2011-10-19" version="1">MGSAAGKIKEDEQRPSRQGNSTGDNTVGTRSATDSELPPPSCDLPQAERTVEENEEDASEDEDKCCSSYSMDSCPQIPKRTRRVSLPGDDEDGAIGSAITKHHSNLARHHRPRRKDSANGKGKGKRRPSVPQQKFDFATAAKTLSSTCSIERQQRRLSLERQHRLSAAGFNTNDSKDRRLTRPCTPVARHYSSEIEGEMNDLSNFSFSEAQHPEQQVSLRERALINTGVMHSPQTVPAGILRKSSYGPQRLSCVLQPNGADNSTASDALEPPSRNILAGPRASVMMRASSADALRDHGKTEDELQRITLLIQQMRGHKEREEGEPVAVAVAGNASNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA77</accession>
    <name>F9WA77_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001404">
        <property type="protein sequence ID" value="CCD14133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="14866" checksum="92F289676717421A" modified="2011-10-19" version="1">MLKTFASEVVFPVPLGLVFRLLWRHTLETASQDLSKPGRISAFYLCTTHGVVSLTSCLLHDHAKGSGGDDKPPGTLLSRCKSRKRTRHRILWKGAPGVVAFLGVSGPAPGAAMTGVREGCRKIFRDSAWSVIHRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB12</accession>
    <name>F9WB12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_50540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001517">
        <property type="protein sequence ID" value="CCD14439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50540"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388928" evidence="6">
        <location>
            <begin position="26"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="56"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="320" mass="35027" checksum="9E71F8BDC4D0DC8A" modified="2011-10-19" version="1" fragment="single">MEWEMWLRVLLVLIVFEMGGRNVEGNGASKDIFETLCKIAGNVSVLMKNKGGNTDLFREALYGENGRGQFEEDGTFKGNCGSLGGPHHRSTYCSHMGKDRQQAKDHGCFGDSLLGTFLCLCVPGQQNGQDLCGLGIEGDGIWSGEWNSGVTPGLLKNVWEKIKGRCTAPNTTADTLGNLEDLKNSVNELKNNAKNNNLSGNGQPGYYLGSSTTANAHCRGSNQPQDGCVTYPDKSGKPDIPWTEKILGGITKLNVAKTEQKTSSTNLPLREHHQEDPEDPSDHDQVNEEEETEEEGELESAPNPGPQNHSKTPRQKRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB48</accession>
    <name>F9WB48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001530">
        <property type="protein sequence ID" value="CCD14479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50890"/>
    <dbReference type="OMA" id="HEDDESW"/>
    <dbReference type="OrthoDB" id="1553668at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30235" checksum="FB5183128FCE6194" modified="2011-10-19" version="1" fragment="single">MLCRVVSNVTEPLDLFIEPAMTVGEVRVLIKEMVCEPGEWNVSLKFQGRTLHEDDESWSSVCRRNPHHEGKAPKIIVLVSSTQEAETRGLGVSAIRNQVDTEQERMEAKMTELAADMLAKNPELLESMLSPQTTLRRLVDENPELRQVVNNPDALKSVIMSYVDPKERRMTNRILQLQMAQLSSVPGGEQLLQRYTSGLLDDLDADLSAIGKPNVAGIDESAGRPDSTKRCNKEPLPNPWSSASSHRGPSQGNPAFPARDPRAHVEGLLPCGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB51</accession>
    <name>F9WB51_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2061</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001531">
        <property type="protein sequence ID" value="CCD14482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50920"/>
    <dbReference type="OrthoDB" id="33681at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="PTHR12609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="39307" checksum="CF221AE477F4D8EA" modified="2011-10-19" version="1">MIYALVERLHDNIKQLNVELALRIVSCLKAAFETQYSAQQCHTNLLFRLLGMIFECLLSESFSLHANVIKALNNVTLTLLERCPPNEVFCALMSRMTKYSSAYIESGTKPDLKYIQVTVKCLIKLGFNDISPENVIICCHEYLVQHPPSAFRNIDDISIRTVKTILQEFSRRCGVSLLETTHALVGTQNLVSHFIRSCLDAEKQGSPQSGLNVGYGTVEHLGKQQMPSHEVVTPTRSGAAEGFVAGTRHVDPQMPAVRASFSAGCNVTAAEEGSVVAIFSRIRNHETTAAGIEELYAFIKKHPHSAIFEQQFKRCSDAFRSYIRRKMERRMAEDSTIPQGFELPEIIRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB66</accession>
    <name>F9WB66_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2068</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001539">
        <property type="protein sequence ID" value="CCD14497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51060"/>
    <dbReference type="OMA" id="QHVENIC"/>
    <dbReference type="OrthoDB" id="1363966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="721" mass="77632" checksum="74B10E99A1C0BA07" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB72</accession>
    <name>F9WB72_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001541">
        <property type="protein sequence ID" value="CCD14503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13341" checksum="6195479A78571FEF" modified="2011-10-19" version="1">MVPSLLAQMGRSSPLEALSWSAAAAHDDLHQSGAGVRDESPPATVEAARHQAMDPFSSCYAVTTFSKIKLGGKGAITGTGRTFMSHGAKTCTGSLLYWFGLRLLPYYVIFFTSFNAVNFSIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH4</accession>
    <name>F9WBH4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_52110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52110"/>
    <dbReference type="OrthoDB" id="1764332at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390110" evidence="2">
        <location>
            <begin position="19"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="18936" checksum="0E87F5702A3823CA" modified="2011-10-19" version="1">MRARTSALLISALSSFSALFPHVPASFAKDASLLTGGLLQWVPHVACLVVPFLDLPHLTHPIPAAHTLQFPLEHGKPHVPATLSSPPLLSAAASSAASSAAMHGGSSGSVAPPCLPIRCRSLLAHALSSHLHTRQANSPLAFGPRPLEDRGCPSPPPPPQLTFLSALGVSLATAISTTGTPQME</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBS4</accession>
    <name>F9WBS4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001623">
        <property type="protein sequence ID" value="CCD14708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53010"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390118" evidence="1">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="234" mass="26899" checksum="5E1BF59D909E28F4" modified="2011-10-19" version="1">MTPLYIILSFLLPLPIPSPSPIGISMSESSSSPSPEGMAQDNPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPHIHSYVSRFSITDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPHYAQCLECILTIMCVDPLYHPGERGLHSHHLKFPPFLTTKRKDGGAFKCLGEEGMFPRGQAQGAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBX0</accession>
    <name>F9WBX0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP_PDE_delta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_53450</name>
        <name evidence="3" type="ORF">TCIL3000_2_920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDE6D/unc-119 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575315">
        <property type="protein sequence ID" value="CCC89516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001636">
        <property type="protein sequence ID" value="CCD14757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_2_920"/>
    <dbReference type="OMA" id="CNSADMG"/>
    <dbReference type="OrthoDB" id="1270912at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008015">
        <property type="entry name" value="PDED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037036">
        <property type="entry name" value="PDED_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05351">
        <property type="entry name" value="GMP_PDE_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMP_PDE_delta" evidence="2">
        <location>
            <begin position="28"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC89516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="22914" checksum="05DC5BAD21BEBFF8" modified="2011-10-19" version="1">MEGASDVTPEMVLQHTGPTQDFLCPITANTYNIEFYSFYIRDADTKQVMFQVERDPDTYPSVETVAMLPPEKQRVARTIYYRFPPSMLRKQRVSATLLFGVNSDKPVPNLRMIERHYFRNTLVKSFDFTFGFCIPHSRNTWEVMYDVPQFDGEWLEAIQQGSNEMVSDSFYFVNGKLIMHNKAFYDYSAPEEEFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG5</accession>
    <name>F9WCG5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_55260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001720">
        <property type="protein sequence ID" value="CCD14958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55260"/>
    <dbReference type="OMA" id="GCVEESA"/>
    <dbReference type="OrthoDB" id="30115at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="PTHR13457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="832"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1470"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1500" mass="163006" checksum="BD52DFA851EB0C24" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCI5</accession>
    <name>F9WCI5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_55460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001726">
        <property type="protein sequence ID" value="CCD14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55460"/>
    <dbReference type="OrthoDB" id="841770at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="206"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="494" mass="51298" checksum="E89D7397104FD21F" modified="2011-10-19" version="1">MLFHTSQCGFNNVPVVSFAPFQAPMGSPPPPQLLGPQVTTFYADTIQTWQGPVQIGKFNSSPPASQGSASSTPPSLSSSGHSAHNSNAGNLNGFHSPSFGNSVLIASGNNMQHYHQQHNRNFSGISGGGSIPSSSNISPMPPVTMSPCTWNFSVPPASQPSQPIYVMLPPTPTPGRAGPAGAALPPTPTAEVPRRSNGMMYELGEWYEGFVKRYNPTRGFGFLTATHHLQIIPPNAGSCTGPRHDTEGENTEQPAPQSQPYIMKTPVSVGDVFVHQSYIRMEGFRALTAGDVVAFRVGKLSGKDAKQAVSVQVLGTTNATNGAAKDGVKAKASQDAGESDISELSTTQARHDSAANEDGTTGRGGPNLADGAGESASISMEMLFAQISGQSAVNDNTPVPSTFCEPASSLNPSTNEPRNDGGGDGGHGSYCGWTGDGVSGSGEFPLGNLLGGCVPDLRATDFNSGVNLHMQTAGWGMTSSSHGTPRPFGGLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCL3</accession>
    <name>F9WCL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2244</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_55730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001736">
        <property type="protein sequence ID" value="CCD15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55730"/>
    <dbReference type="OrthoDB" id="1681335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="281" mass="31121" checksum="FA65D132E453471E" modified="2011-10-19" version="1">MAKNTFNQVIFGKNGKEDLSHEALEVVPSRMAACGSKPLEKKGQSAGKNLIVDFFCLCAKHDVEDGVDKVCGVSVGNGRDSRWEGGTLDSANTMWDEVKNGCEKFFKNGVTSTQDGYSLYNDFLEKVKVGGNVKLKHSSTVHKPGMLGTAVSETEKNDFHCNGKKEVNNGRFNVGSGSGVCVSYGNHHREQNIKWLSQFKAGLQLVDQLNTETASWQHQLTTLLNRARELYEKVKADTQQEEVDTDESPLTQHPNPEENENTDSATRSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCU9</accession>
    <name>F9WCU9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001769">
        <property type="protein sequence ID" value="CCD15097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15967" checksum="43BCFE2397C102D2" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCRILRVAEWESRGESPMSSARARRLFANWKAVSVQQEVLRLADTEREAEDFVTKLVTRTIAHENAKHAMERKEIYVPIEEELLRATKWRVCGRRTVSFTSFAACLWWRLQWLKTLPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD86</accession>
    <name>F9WD86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001836">
        <property type="protein sequence ID" value="CCD15237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57790"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20169" checksum="0CEE878BDFA57525" modified="2011-10-19" version="1">MSNSPSSPSPEGMAKEDTQWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPFIHSYVSRFSITDFSRNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDJ4</accession>
    <name>F9WDJ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 237</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001877">
        <property type="protein sequence ID" value="CCD15348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06040"/>
    <dbReference type="OrthoDB" id="272944at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1422" mass="158242" checksum="6772192FCC011C86" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDL5</accession>
    <name>F9WDL5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001884">
        <property type="protein sequence ID" value="CCD15369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58960"/>
    <dbReference type="OrthoDB" id="1668779at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390189" evidence="5">
        <location>
            <begin position="24"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="28"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="84"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="44132" checksum="78A69966CECB6BDD" modified="2011-10-19" version="1">MMKLFMVMMVVMGSWVREWRVKAQGGLTVSQDDNSEYFALLCKIYNVAHNPPIKPVDTKEYQKIVDDINALSAAVNGKEGVNTQSEEARSAQTQLIGVTHEARKLLDAIKKVNPEREAEMARNTFNQVIFGKHGKEGDLSHGTLNGVLGRMAACGSKPLEEKGTSAGKNLVVDFFCLCAKHDVVDGVDKVCGVSVGNGRDSRWEGGTLDSANTMWDEVKNGCEKFSKHGVTSTQDGYSLYHEFLVKVKVGGNVKVKGSSTTPRHGMLGTAVSQTGKNDFHCNGKKEVIRSRTSSSGSGVCIFYGNQHQEENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADSQLEEENTDDSPLAQHPNPDENENADSATQSMRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDU3</accession>
    <name>F9WDU3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TCIL3000_11_8230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59670</name>
        <name evidence="2" type="ORF">TCIL3000_11_8230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001914">
        <property type="protein sequence ID" value="CCD15447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.8230"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59670"/>
    <dbReference type="OMA" id="VYRWVYR"/>
    <dbReference type="OrthoDB" id="1049912at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC95373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="241" mass="27658" checksum="FD2CF26B211D8025" modified="2011-10-19" version="1">MSRATTRIGGGMARSNVVEHTAYVKPITHNPYIYAVHDGVSTGYQEGFSAKPMHWLYRFRYNLLPQGFACGFFARNPYGRYVHWLEVSTIEKMRLQLTSMESLPATVLTLIVVVYTIWFSYRLAFLHPDITLYNLVLWTTKPWVSAQRFNKKVWLDQPVYRWVHRAPEYYITDPYRELTKLGVAANDTWLEHVKSIGREEELLIGPHDAGYGVDGKGKILPVVIPHDDKSGHSPAPFATTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE12</accession>
    <name>F9WE12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_60230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001936">
        <property type="protein sequence ID" value="CCD15517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60230"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390205" evidence="6">
        <location>
            <begin position="22"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="81"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="98"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="424" mass="47090" checksum="6ED8AA2C452CE0BD" modified="2011-10-19" version="1">MIMIKTFLLVALVFCVGLGSGQPSAAEFNLFCRILAKADDMMYGPGYVYDENADKETIKEMTVLYNATTANMKDFGNSLWDTKEFLKEHPPPMNPKNREDAHREIDKLIKEGERKIEENKKIAEKVNEKIKEAQLSVARGIFGEHVNEVPKNDGNLTKILNNTESIFNDNDSPSRSCGNSIGAGKTLLNDFFCVCVGDGDTNSEGPCSPHILPSKSGGGNGGWKAMKYQTASKPALEFNQSFKAIEEVCNEELMAETKQTKDINGLLAEYVGLIGEGAAKKEGNGKKIFGHSRRKEQNKVTKCDGSQGDGNGDGNNGARETANANICVDYSNHFKGDKYDIPWHKKFKNYTTLMKSAKDLEDQILKNRADLLLLKSQAWVAYSREKDDETSNLDDMNVSHLFDTTQLPPSIPLPYLLLFLFLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE52</accession>
    <name>F9WE52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2441</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_60500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001954">
        <property type="protein sequence ID" value="CCD15558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60500"/>
    <dbReference type="OrthoDB" id="1170065at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.375.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000840">
        <property type="entry name" value="G_retro_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036946">
        <property type="entry name" value="G_retro_matrix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003036">
        <property type="entry name" value="Gag_P30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008919">
        <property type="entry name" value="Retrov_capsid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010999">
        <property type="entry name" value="Retrovr_matrix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01140">
        <property type="entry name" value="Gag_MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02093">
        <property type="entry name" value="Gag_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47836">
        <property type="entry name" value="SSF47836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47943">
        <property type="entry name" value="SSF47943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="2" id="KW-1043">Host membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="508" mass="57338" checksum="CA2E15593490FC0F" modified="2011-10-19" version="1">MGQSVSTPLSLTLEHWKEVRVRAHNQSVEVRKGQWQTFCASEWPTFGVGWPPEGAFDLSLIAAVRRIVFQEEGGHPDQIPYIVTWQNFVQFPTPWVKPWTPNSSKLTVAVAQSDAAGKSGPSAPPKIYPEIDDLLWMDSQPPPYPLPQQPPAAAPPQGPAGGTRSRRGRSPEEEGGPDSTVALPLRAHVGGPAPGPNDLPLQYWPFSSSDLYNWKTNHPPFSENPSGLTGLLESLMFSHQPTWDDCQQLLQVLFTTEERERILMEARKNVLGEDGTPTALPNLVDEAFPLNRPNWDYNTAEGRGRLLVYRRTLVAGLRGAARRPTNLAKVREVLQGQTEPPSVFLERLMEAYRRYTPFDPLSEGQRAAVAMAFIGQSAPDIKKKLQRLEGLQDHTLQDLVKEAEKVYHKRETEEERQEREKKEIEERENRRDRRQERNLSKILAAVVNDRQSGKGKIGLLGNREVKPLGGRKTPLEKDQCAYCKEKGHWARDCPKKRERSKVLTLEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEA2</accession>
    <name>F9WEA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001964">
        <property type="protein sequence ID" value="CCD15608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15700" checksum="A2561A390B77485A" modified="2011-10-19" version="1">MKVCEAQYAEAADKVFPQQHAIYSKLEKVRHTYNTIEVSVRQHEATVLQWAKEVYFNTTAPGVLKAETPEEERKVHTMRRVQRFNDYDYQAWTDGPVVLGVSSGAEALVYPPNGKKVRRSLCVVETWISASGRNVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEJ7</accession>
    <name>F9WEJ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 279</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002025">
        <property type="protein sequence ID" value="CCD15707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07200"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390227" evidence="1">
        <location>
            <begin position="37"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="25225" checksum="64F8AE3A6B1424D3" modified="2011-10-19" version="1" fragment="single">MSKQTALMVASGFSRIMMQLLFLVLLLVLHVHHVDSHSKTEVEVLSLFHNKHVPARITNAINAGVGASFAARKIDFEGLRVAVNLTNLRQKNHSTIELLERRLSQLSGTKKILAVLGPIGDATILRVIPYLDRHKVVAFAPVSGSAAVRGWKQSLYFLTPDPMAEVLALLRYALGQLRVLRLGFMYLKKVSLGEDEYESVVNVLDRMGYKLCGVFALEGSLDGEASESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF37</accession>
    <name>F9WF37_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 344</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002097">
        <property type="protein sequence ID" value="CCD15905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08970"/>
    <dbReference type="OrthoDB" id="1712181at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="207" mass="23975" checksum="FD7270B5DEDB438E" modified="2011-10-19" version="1">MEARLPVTLPLRDPCFYNPPFFNDTFKPKQYTKEKTGKIESLLSSAFIWTAMGNEQNNVKQNKWHPTAMSRFALPSTNIFISKQITSTPTPNTPHTPPCFLSTPVTLLEGNCFQRKNKLFSSFVFERQRNTNAIFPVQKSMRRNSFSILLFSLQLQRVRKKLQLPSKRPYPPNGLLQVGTVAYTLRGFCDNRHQSFLKLPRALFMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF91</accession>
    <name>F9WF91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 362</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_09450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002117">
        <property type="protein sequence ID" value="CCD15959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09450"/>
    <dbReference type="OMA" id="CDHMHAT"/>
    <dbReference type="OrthoDB" id="652179at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394977" evidence="1">
        <location>
            <begin position="19"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Sialidase" evidence="2">
        <location>
            <begin position="127"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="575" mass="62781" checksum="20741E2942660995" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFB4</accession>
    <name>F9WFB4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002123">
        <property type="protein sequence ID" value="CCD15982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14528" checksum="9148719E926788F6" modified="2011-10-19" version="1">MRVSTTFLFCRFTFSNFPFQIRQLPCPERCHSVPLLYRHPCRDANCRRSGLIYFIFIPQGHSRITQLPDACVAKYFAVRVTLRSVGRCLQECTSSTSIPTIVLEVIRLFSFVTFISGRQLNTSRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK0</accession>
    <name>F9WFK0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 396</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002155">
        <property type="protein sequence ID" value="CCD16076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10390"/>
    <dbReference type="OMA" id="KETESLW"/>
    <dbReference type="OrthoDB" id="1181500at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34366" checksum="18052620C16E892F" modified="2011-10-19" version="1">MVFASEKQENAPLLIEPAIVEATKIYRESVSTLSIAVSALLQMKTLTAKETESLWFFFAVTSHALCAVMPEYFLAVDDFGTHAEALAKGLRLLMYASNMAGSNATGGRLPLVNCAQHGKETQWLNFCVSSFETPSSLEVRRAAVLEEMIALFPEYAPLRLHYAVSLAMSHQLIGTDSVISLINSEREKLSTRAHIDPHHDSFLSLCKAFVLSTTNITSAAPNVTAVNATDLQTVAHEAVKRLEEIATCNSLFRPFASDGNSSWTAMFRNAGRPDVIDKWQAMKLLSTMKTLKQQFPVGEEISDALPEGFANCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFV0</accession>
    <name>F9WFV0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 426</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_11290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD16180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="APGQEFK"/>
    <dbReference type="OrthoDB" id="426277at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
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        <location>
            <begin position="46"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="3">
        <location>
            <begin position="260"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD16180.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="514" mass="56499" checksum="5E0BC195FAF1604A" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11730"/>
    <dbReference type="OrthoDB" id="1699322at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="236" mass="25624" checksum="BC7597A546F38CA9" modified="2011-10-19" version="1">MLIGSAEGNSPPKAHPIVAADSLSLPSGVFSSVSSALRGVEPQHIPQERLAQHQAYFTAKGGPIKAHLDGEPSSLDAQIACVLLVAFESCMSIPLVPLTNSNGTLHLIAIGRLSAIPQANNNAWHLGLRKSHFRILQEPFPLCSEADRANVPLQPGLPSRRLLISSSHSSRNWGRVSPLTNDKWPPKENFSTRKVLSYACNQLPLTRVRKAVHLLIIFFTVNPASDEVRRGYTAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG66</accession>
    <name>F9WG66_TRYCI</name>
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        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 470</fullName>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002237">
        <property type="protein sequence ID" value="CCD16300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12400"/>
    <dbReference type="OMA" id="ISHYSEI"/>
    <dbReference type="OrthoDB" id="1723at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HECT_dom"/>
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        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
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        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
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        <property type="entry name" value="Vid30/RanBPM/SPLA_SPRY"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1762"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="2165"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="2455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2487" mass="273363" checksum="CF3DF314F86CB21C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGG7</accession>
    <name>F9WGG7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 499</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002269">
        <property type="protein sequence ID" value="CCD16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13270"/>
    <dbReference type="OrthoDB" id="1679021at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36098" checksum="44201F8466E2A6DD" modified="2011-10-19" version="1">MTLSEVISGFVKMTLFEVISGFVKMTLFEVISGFVKMTLFEVISGCVKITLSVVISGYVKMTLSEVISGYVKITLFEVISGCVKITLSEVISGYVKMTLSEVISGYVKITLSEVISGFVKITLFEVISGFVKITLSEVISGFVKITLFEVISGFVKITLSEVISGFVKMTLSEVISGYVKMTLSEVISGFVKITLFEVISGFVKMTLSEVISGCVKITLSEVISGYVKMTLSEVISGFVKITLSEVISGFVKITLSEVISGFVKITLCEVISGFVKMTLSEVISGFVKMTLSEVISGFVKITLSEVISGFVKITLSEVISGFVKITLSEVIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGM7</accession>
    <name>F9WGM7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002292">
        <property type="protein sequence ID" value="CCD16464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13840"/>
    <dbReference type="OrthoDB" id="1724627at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="18237" checksum="80D829A303EEA0B8" modified="2011-10-19" version="1">MHPRMEINSEPCYYYSQHSLRLYSLAHISVLFLLPQLRRVVSPNPVVYLDLHAFNYYELLPPLSLSPKHQKRERKEGKERTIGCIGGFIHHHVRPVKECSYTMGTIYLWPQLQDQERENQVRIITSQFLLRSIDWAVGCQNAQHARAFPFASLGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGQ9</accession>
    <name>F9WGQ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14150</name>
        <name evidence="2" type="ORF">TCIL3000_4_2900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575317">
        <property type="protein sequence ID" value="CCC90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002305">
        <property type="protein sequence ID" value="CCD16496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14150"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_4_2900"/>
    <dbReference type="OMA" id="LAFTIEY"/>
    <dbReference type="OrthoDB" id="1410108at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28939" checksum="D6F68FABB6CEB602" modified="2011-10-19" version="1">MHTFYTVRYPPPKGNADCQPIRVTDKAMESMLFCIVHTIEFQCPVQCQSIRPTSSRRTALPFGKEGGDGSKDEKRNTDAPEKYVCPVENTSSLLGNVTYVACAEHNPSVLASLQVAVDEARAIAIPEGKQYVSFELCVRLRHSQRRWLWDESRPLVEWVFRMVKTREKLSPPAAFDNCSWKQQRPQGAEMGTPAAHRCSEGSRTTTDEGAVCSNDPTQIRDVLQFILKHSYDSIDLNTFSDFKSGELVFDIFVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGU4</accession>
    <name>F9WGU4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 550</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002326">
        <property type="protein sequence ID" value="CCD16532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14480"/>
    <dbReference type="OrthoDB" id="255081at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand_13" evidence="2">
        <location>
            <begin position="663"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="736" mass="79517" checksum="F57AD10CDBA912FF" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH66</accession>
    <name>F9WH66_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 603</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002384">
        <property type="protein sequence ID" value="CCD16655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="210061at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20005" checksum="5A4C00A4E01A33B3" modified="2011-10-19" version="1" fragment="single">MRPPVPRVFASLNALRCSGVAVSGSGVGCSAQFSPLLKLGLLDTAPQEGLLSSLRQLPQERLPPSLAFTFLSHCWYRWSTTAFSDSVASESCGRGTEDSAVLETLLKVSEEALRVYYQVENREHSSSSRRETDPRATKVGASRSSLPCVSDGVGHHHIVEHMLRICGDYVGLRAIGVLLTYAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA8</accession>
    <name>F9WHA8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 623</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002407">
        <property type="protein sequence ID" value="CCD16698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16040"/>
    <dbReference type="OMA" id="FCNETGH"/>
    <dbReference type="OrthoDB" id="862118at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="SSF57756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39079" checksum="E139FE74FD2FF79C" modified="2011-10-19" version="1">MTDEGLEEKFTKAASLVRGKNHVDAIGIYMTICNDQRCTDEQKVRALSNLSACYAAREQFTEALNTAKQALHLDESSGKIQGRVATAYHGLKHYEEAARHYARAHELDPTTALYKVQHQTVLELIRSGRGVASKETLDSYYYRKGIEQGKEAMLKGEYLSAVRHFTKAIELHTKCAAGENGSTGGSGGSVSGDLAVLLCNRSAAYARSCRWAESVEDGLKAIELHPTYARAFFRVGYAQHRLNHIKEAHSALRRCLELEPSHAEAKDLMAEVEKLIADTLKSAEERRREEEAKISEIREKQSAQRAAEGVSYATGGRGRAHATSYVLCSYCNEGGHTREECPLLRRKRSRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC8</accession>
    <name>F9WHC8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 628</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002413">
        <property type="protein sequence ID" value="CCD16720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16260"/>
    <dbReference type="OrthoDB" id="1104994at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="375" mass="41168" checksum="62164A4F3ECC6E05" modified="2011-10-19" version="1" fragment="single">MFVWAAAEMLERRKRGASSLYHCMPPFHGSGKMMYGLNMLQQCYLRCGRCSGNLVSQADSHVSKDTCWRCGYLVCSSCRDCSSQFQHLWTCCICAKQLSFAWLFGKTAHGLDLLLSVAEYVEPDTLHVLSDVFGSAKVRNLLYHKATVVESSAASPEKIVQQSPLSPQLLTPETCGEDSPSLKFASQPRHGAGVATGKACTRRVIRRPRSEERQRHSVSVWKDRKPLISSLIHSAFPERQVKSIKGANSNSSCTSKPDRPQGKKVVEASGSTVRKTGASIALDLSHTQETHHRQGSDAEERLNSQFLRSDAATLGPPCAKHCQGSGTNMLQEWGVVRSAGDSPPPRFPNFSKFLDGPEGLRVRSSSPHVLEVGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD8</accession>
    <name>F9WHD8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 632</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002417">
        <property type="protein sequence ID" value="CCD16731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16360"/>
    <dbReference type="OrthoDB" id="1713184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19768" checksum="3A32027E8AE419BA" modified="2011-10-19" version="1">MVMHVSYLPWEREAERSRASVLSRYRLPASIYSFEAADQQCRLEEKWLYKHGWKNFPIACGFFLVDAVSEGVSLSEGAEAPTQAMVLLKVTKTRYHHTKTSKVKRFLNRMAETFTNWDEMESRLRCEIIYLLHADSATIKTRQRCDSGGMACDAGIEEFCDGIGQLLVKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHH3</accession>
    <name>F9WHH3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 649</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002436">
        <property type="protein sequence ID" value="CCD16766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16670"/>
    <dbReference type="OrthoDB" id="1771146at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="20535" checksum="3E03A7C3F9A93F29" modified="2011-10-19" version="1">MRPRRRLRKLRGSGGSDDQRRWLLRRRAKKDRRVKKDRRVRKARRARRARRVRRVRERCLRKARKARVRCLRREVLHPRPLRTVRPLLMHLRREVLHLRPLRTVRPLLMHLRRVALHLRPLRTVRPLLMHPSKPQSPELIQMRRVPKHSSLQKGLLRGQSAPHKLVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHT0</accession>
    <name>F9WHT0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002484">
        <property type="protein sequence ID" value="CCD16875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17590"/>
    <dbReference type="OMA" id="WLFLPTV"/>
    <dbReference type="OrthoDB" id="580699at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043965">
        <property type="entry name" value="CBP66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19043">
        <property type="entry name" value="CBP66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="579" mass="64981" checksum="7B91D4682C720B46" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHU8</accession>
    <name>F9WHU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17760"/>
    <dbReference type="OMA" id="ARKFCAF"/>
    <dbReference type="OrthoDB" id="1129083at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="745" mass="79916" checksum="13507BDB10D510EA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHY3</accession>
    <name>F9WHY3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 705</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_18100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002498">
        <property type="protein sequence ID" value="CCD16928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18100"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="328" mass="38717" checksum="ED7A0B3934F0190D" modified="2011-10-19" version="1">MGEVHWNKRPPXPYANDEGMWAPCLHPLCEQEFPSYEEVERHIQDDHLNWGKPGVDFMMFVCPFCLSHCETYKRMIEHMQHDHEDEEDNHPDSAGMKCRYCEERFRSYGDVVKHIEKDHSGEPALDDDMVVQSMQFKCLQCEKTCASYRGLGEHIGEVHWNKRPPQPYANDEGMWAPCLHPLCEQEFPSYEEVERHIQDDHLNWGKPGVDFMMFVCPFCLSHCETYKRMIEHMQHDHEDEEDNHPDSAGMKCRYCEERFRSYGDVVKHIEKDHSGEPALDDDMVVQSMQFKCLQCEKTCASYHLLREHMRDHRKPTRAGDSHGKTDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI28</accession>
    <name>F9WI28_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002519">
        <property type="protein sequence ID" value="CCD16973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14783" checksum="2118A97E47B17B99" modified="2011-10-19" version="1">MEMRHCLVSTTVDLWLRPTLSFSMSGDVHRNTRGISTSRLWKTLQEDSPPLYTNCSHSITMVTGAFFSPTATTRSSKRRSFLSNQLVRRASGHFATRTLHYGLSIHTFFPQRAAKDGMSRHLTRLSKCGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI32</accession>
    <name>F9WI32_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 725</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002521">
        <property type="protein sequence ID" value="CCD16977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18460"/>
    <dbReference type="OrthoDB" id="1523267at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="328" mass="34498" checksum="9C34955DA33C566F" modified="2011-10-19" version="1">MMGRVAANTGKKAEKAASHLRSKKPQQKGSRVPKRRILGKVARGAVVGKGSMVATDGKSTCVSTASLNTVKNKRGKRCTHVPLKVALQSGEVQPDAPSNDNSQGVTTRSNVVLKGGRGRGRRLAGTEPVVPHDKVEVSNASAATKKPSAQTFEEADKSAGVGVAPVQRNIGGAITLNCFVSESDADRKVFRLPLIMDGGHLGKCGGEPPKPVPSDTPPEEREASVGKRGNMSSAASVPQQDGVPREDTETAKSSGNVPTNVNENSVVVNEEVTPLSRQQELMQIPADRLALYVRLAESGLDAADRPFVACVVKHAQTMVSAWASEFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIP0</accession>
    <name>F9WIP0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_02300</name>
        <name evidence="4" type="ORF">TCIL3000_0_53550</name>
        <name evidence="5" type="ORF">TCIL3000_0_57420</name>
        <name evidence="3" type="ORF">TCIL3000_5_5340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001642">
        <property type="protein sequence ID" value="CCD14767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001820">
        <property type="protein sequence ID" value="CCD15197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002620">
        <property type="protein sequence ID" value="CCD17188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010833326" evidence="2">
        <location>
            <begin position="30"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC90769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16554" checksum="34C610CA45D0C871" modified="2011-10-19" version="1">MKRLSWSGMKAVVLFLCVLWVLMVLGTLAHNGKNGFQVLFEVLKHAERVLNKTGRERYPLKKPPYRKPGGFVTVPNGMASVTRNNNGQPHTVLLCFYYNVGKYGSFAESLGGHSWFSLHTWGSEPWRKTPVPFSKPAPTPAAAAGRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIP7</accession>
    <name>F9WIP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002624">
        <property type="protein sequence ID" value="CCD17195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20320"/>
    <dbReference type="OMA" id="QMGVNSA"/>
    <dbReference type="OrthoDB" id="637646at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034464">
        <property type="term" value="C:BBSome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028796">
        <property type="entry name" value="BBS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44177">
        <property type="entry name" value="PTHR44177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="547" mass="61116" checksum="44E2DC3B1745CFC5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIX4</accession>
    <name>F9WIX4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002652">
        <property type="protein sequence ID" value="CCD17273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14800" checksum="F01BBA46F5A78AF9" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCGILRVAEWESRGESPMSSARARRLFANWEAVSVQQEVVRLAYTEREAEDFVTQLVTRTIAHGNAKHAMEREEIYVPIEEELLRATKWRVCAGEEQSHSLHLRRACGGDCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ20</accession>
    <name>F9WJ20_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 861</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002671">
        <property type="protein sequence ID" value="CCD17321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21490"/>
    <dbReference type="OrthoDB" id="1580233at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="22078" checksum="8202E96A84750FBD" modified="2011-10-19" version="1">MSFYTITSPRTRPWSMERDVVDVLLEGVTSADRINLYWFLRPVLAGLTVDLICFTLGDFVRNPRHCIPEANVCDAVWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYFDNDDMPLEAIDEEIWRRCRRPPPVHNTNPTRKSFWSKRRRLSYKCRIPPWDISFRFQFPHDHGVGYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJM8</accession>
    <name>F9WJM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002747">
        <property type="protein sequence ID" value="CCD17535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23500"/>
    <dbReference type="OMA" id="FQHIVET"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17234" checksum="DAC6C6B51FA07DA0" modified="2011-10-19" version="1">MTCGAEWSIGELSQVKLIALEGWLHEDHLLFSLLQETPPALEERSAFKISAYQDVELAINPHGGGVSIAVRDGVGVEVGILEKEVPERATVTLRLSADVNQMIISAYFPQKDRCFQHIVETVGGCKRTSDYKSRGPLTSYVVGPLSPSDDEEECMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJU3</accession>
    <name>F9WJU3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 952</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002772">
        <property type="protein sequence ID" value="CCD17601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24080"/>
    <dbReference type="OrthoDB" id="1726379at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18122" checksum="AB65B800C7766842" modified="2011-10-19" version="1" fragment="single">MQDQRVSGFTCVYFPAFYFPQPKTRCISYDANLMRAMRKPITKQNQVGRNKLTNGRCGPKTHLPLPSIFAEGLHFYPSPPSRSYRSCSNCYHSAAAAEHSSCDAPPGDPSDTSSHIPYVLHITSRICSFLLLFGLAPLSRSPRDSVDFAAGGNTAAPKPGDLAVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX8</accession>
    <name>F9WJX8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 965</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002786">
        <property type="protein sequence ID" value="CCD17638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24440"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="249" mass="25847" checksum="0EB2FE92D17A3F6F" modified="2011-10-19" version="1">MNLATGLLHTLPLTHATSEDNEQRLCGGRESDDAVAESVGKLPLVTAFVLPTWTVERVKQPAALDPVDVASSFAAASDKMCQERVSPPPAVAPASAPPSQKVWQEGTAAPATAGPMGPATGDGTNLYNPGAPGGVEMDPMREVVSPQGREMLQLSQQPPTPAPLLCKGSAPEAQTRMLALPSDTLFSKDAPLTSALSAFQQSSPFGGQDVRDTALPHAAAVSEEVQVLPPIEIPSPLQFPVIKPAAPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJY7</accession>
    <name>F9WJY7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002789">
        <property type="protein sequence ID" value="CCD17648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="14330" checksum="A3AE33B4EBD7B196" modified="2011-10-19" version="1">MGFLIQKFAPTYGISKPTITLVAFTENISEYTLDEAPVDEVTKHVHQNVPHTKACFFSDAAFPQVVDMNMLKQWVRWWCYHEMIDLATRSVFRLSAHAVSKRKDRKRGEWKNSRDITEKHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJZ3</accession>
    <name>F9WJZ3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VSG_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_24580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002792">
        <property type="protein sequence ID" value="CCD17654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17201" checksum="8DAFF467CC8E0DA6" modified="2011-10-19" version="1">MPALLEEYVEMIRKVDKDKRIFGHSGRGKKEEVTTCTGEQGKHGSDKEKNNEKICVDYGQNFKNGQYEIPWHNKFKEASERMNEAKKLEDKILQNHAEIVLLQSRAWIAYTLEKEDQTANLDDMNVSHLFDGAKLTHEIPLSFIFLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D7</accession>
    <name>F9W3D7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_26130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000397">
        <property type="protein sequence ID" value="CCD11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26130"/>
    <dbReference type="OMA" id="QFMEMIS"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="7">
        <location>
            <begin position="154"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="426" mass="48019" checksum="B87E4BB28F2A53FC" modified="2011-10-19" version="1">MLSFCFLFSHYFHTFIFFVPLLVFLPTFFLSLITLISYIIIYCYYYIIVIIILLLLCYCGIIVPVAVTAAAGVQLLVAPVAAQAHAGTFPVCLVLTHISLLPLSARLREPPSLADKRFSHDTATTPAAKMTETFAFQAEINQLMSLIINTFYSNKEIFLRELISNSSDACDKIRYQSLTNQSVLGDEPHLRIRVIPDRTNKTLTVEDSGIGMTKADLVNNLGTIARSGTKSFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNDDDAYTWESSAGGTFTVTSTPDCDLKRGTRIVLHLKEDQQEYLEERRLKDLIKKHSEFIGYDIELMVENTTEKEVTDDDEDEEATAKKGDEGEEPKVEEVKEGEEDGKKKKTKKVKEVTQEFVVQNKHKPLWTRDPKDVTKEEYAAFYKAISNDWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I4</accession>
    <name>F9W3I4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000414">
        <property type="protein sequence ID" value="CCD11702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="14719" checksum="D8E5E5B722122493" modified="2011-10-19" version="1">MYFLPSLRDQPSNFAADLLSIPNCIWVEASRESPSCPIASFRVLRVACLVLEVLGGVGKLVDPLNATIFQGVIVIHADTRDMGGVARMTLIFRSIHIPKHPLYLGLRLFLSTALSNSAGSLLIFLRVWVSGDVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P3</accession>
    <name>F9W3P3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1086</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000447">
        <property type="protein sequence ID" value="CCD11766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27130"/>
    <dbReference type="OMA" id="WREESAS"/>
    <dbReference type="OrthoDB" id="1316883at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="680" mass="74416" checksum="311C58FB9E2DB8E1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3W4</accession>
    <name>F9W3W4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000484">
        <property type="protein sequence ID" value="CCD11840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27820"/>
    <dbReference type="OrthoDB" id="1662554at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389768" evidence="2">
        <location>
            <begin position="25"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="469" mass="52213" checksum="C6A6BFACE7E2D11B" modified="2011-10-19" version="1">MRMAPLHSHCRFALLIYISTKTFSQKTMLTTKSIGMGCCLLYFFCLFGGKGLVARTMKDTEVIGKGKGKGKGKEKGVWVALLVMVMGMRRVSGSYEDYENGHNFNGKEHEALCSVFKASADVWEASKGSPLTLDKNLEYGVRQALFGTYDGKIPERITEGLPAAYNTHSLKYRGTRCGGCPGGDTNYFAGWSITHDLMCLCTPGYYSEPFYYWILGFIYRETGFRLCGRKREDMVPDQYQGWYSYNGYKQAKGLHSSWKAVVLGCYNNRTKRRETKGHNLEEKVKKLSEATQHFTTLLKQSGGRSKLGGFEKHHTESDGKDEKSMHVRYGACNDRRQPWWKKLNEALMGKKPQELIKRPSSASSGAGPAHNRHTRSTGGGMSISQEEGGESKDPGDTNTTTLDDSYALELDSNSTHADNTSTDTNGIGAHAEDHDDDPGPLTFHYLRSSSRRPRASPLLVSLPLGSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W415</accession>
    <name>F9W415_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000502">
        <property type="protein sequence ID" value="CCD11898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28360"/>
    <dbReference type="OrthoDB" id="1718960at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18393" checksum="81DE89EC15CB9829" modified="2011-10-19" version="1">MEVHTHTTVTNTVGIRRLLHRHKHADSRSLTSHTPSAGHPRNLEWRSGGGGVRTTHPPCLWAWGGAVKINQFKAAAAILSKEKTPAIQSAAAKYGIEISHAGDNSNHNAAILHHIPSTTRSSIIGITPCDIIENDWKGTGNKAGNRGQLRKDNTISPTCSISLNCTMWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W453</accession>
    <name>F9W453_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1147</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000515">
        <property type="protein sequence ID" value="CCD11937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28740"/>
    <dbReference type="OMA" id="LEVYCAD"/>
    <dbReference type="OrthoDB" id="1248045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="317" mass="35118" checksum="9DEC70FF10C5153A" modified="2011-10-19" version="1">MNFLRQKLFMRDTPAALSTSGKPLPLNYKLSTFRWHLDSRPPSKAILVHDLFSSSASWQTLLHGSIGKMPGRGLTPRVPLELYAVELRGHNYSMSVPFPEEGSPFALTCASDVLLLQQQIIRTDAKFIGFGFGALVACHAALQSPDSGVDSLVLIVSKASQLMACDPSEYVLPSIISKIPPGLKTLEEFNDHLRKMVPSEVERSLIFSLVVQKDGALSFRLDESLLKLREPLHCFADMGTTGTFKRPVTVVICGEEEFPKKSKEQFLKHFPKTRFVLFDGDRSAGINGLFTQSEVFGRTLLDAMELLGDVTTNESEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A0</accession>
    <name>F9W4A0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_29140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000533">
        <property type="protein sequence ID" value="CCD11988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29140"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394545" evidence="5">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="78"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="439" mass="50037" checksum="4B5F6E30A30B8401" modified="2011-10-19" version="1">MMLIKILLVVLLLCVGLFSAQPSAPEFNLFCRIIKKANDMMYGPNYVYDEVKDREVVKEMEVLYNATTENMDEFGKMLWKMRDFLGEHPPPIDTKNRKHANREIKKLIAMVKKKIQETQKLVDNVNKKMEEAKLPVVQGIYGDEVKEVPKEEGKLKDFLRSTNTIFNSETSVSESCGSNDKTGKTLINDLFCVCIGDGSCSQSAPPCHPDLKPATKADCTKNDCCCKENCCTKDKHGCCENTDCCNCRWTKMNYKDEADRVLNLTESFEKIEEVCLNLLKDADQSKDMPALLEEYVDMIGNGGNKTGNIFGHSWRSKEKGDIKACTGAGTYAQGTDYEKYNELICVDYTKNHKGVKNYYIPWHEKFKKYSTIMKDAKKVEDEILQNHVEILLLKSRAWTAYSREKDDQTDNLDGMNVSHFFNGAHSTNIIPLPFLFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4A9</accession>
    <name>F9W4A9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1164</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000535">
        <property type="protein sequence ID" value="CCD11998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29230"/>
    <dbReference type="OrthoDB" id="1060685at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028830">
        <property type="entry name" value="Mlh3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="PTHR10073:SF47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL_C" evidence="1">
        <location>
            <begin position="209"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="427" mass="47372" checksum="C4802713345A4F28" modified="2011-10-19" version="1">MGGVVVISMHENSRACYVVDERHHVYRHAGAFPSQLQLLLVFVAEDILEGAENDLRRMFQLAARRHYQVAMPDQTTVTSNENIGTLNVIGSLSGTKGDIGRCDAVSSGLRVSLLTSRLAATDHAAARGRREGCSRSAGSAPRRTPFCPIKLTLPTHSINILPRLRKTMQVTVNPAVVAQRAYDAPVVWAGNGGAKGERHTTCPFRAGHFIGQWDHKFLLLHKNDALDRKRENLTYPSILYISDQHAVHERLRLEYFIVNAESYLELPSSSPTFFAVKIPDDICRDVTDYEVALQQWGWRFSYSTADRGTPRLCVAVRHWPNLVVEGHRLHLEGIGALRRTVEEFSVVSQTRGAPTDGAGVIPSAVLQFLITRSCRGALMFGDRLEERHAALLIDSLRAVSQYCVCSHGRPAFAAVQCLRPPRVQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z5</accession>
    <name>F9W4Z5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000635">
        <property type="protein sequence ID" value="CCD12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1541458at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="643" mass="69204" checksum="7E13E5D925CDC54B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9W528</accession>
    <name>F9W528_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_03270</name>
        <name evidence="5" type="ORF">TCIL3000_0_03280</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000649">
        <property type="protein sequence ID" value="CCD12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000649">
        <property type="protein sequence ID" value="CCD12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="VMTKYER"/>
    <dbReference type="OrthoDB" id="1488436at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15915" checksum="8CB18C2E16A711AC" modified="2011-10-19" version="1">MSDRDDDEGDRLSLSIGDEQETVSRSDDEQSDAGAGVIVSGVAGGRGAAKRRDDGDRVTSPVLTKYERARILGTRALQISMNAPVLVALEGETDPLIIAQKELREGVIPLIIRRVLPDNTYEDWRICELDVDFDRPADERYTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E6</accession>
    <name>F9W5E6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_32780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000707">
        <property type="protein sequence ID" value="CCD12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32780"/>
    <dbReference type="OMA" id="NYVVQCI"/>
    <dbReference type="OrthoDB" id="1364009at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="3">
        <location>
            <begin position="61"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="277"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="46132" checksum="A5922BDEFF56F6A2" modified="2011-10-19" version="1">MTRGFDHLTMMTAPVSSRLRNDVGNRVEKMHSPLYHQQCHSVWEFAKNLQPSVPTQSIATTPTSVAEATACRNHRYTHNPYASAGAWGGNISVDAVCNTGDGGHKPTSVPCSESGVDAVSLSSGLIGRFRGAAGELSRTACTSAGRNMLVSVLRLHHVEMTRAIVDELRPHLHVVALDPNGCHVVRALVEFIPTTLMVTLVPHFTPSIVRALAIGSPYTRRVLQSIFERHKCEALTPIVESIARDSQQLAQRQQGCITIIRTIENTLPHQQRSLIVQLLPALPALTMNCYGNYVVQCVLRHMDRGAITAVVCQAFAGHWVALSCNKFASNVVEKVVRLLDGHARSALIAETVCDPANLRRLMNDCFGNFVLQAIIDSSRSKADFRMIAQCVRPLLQTCSHGRRIESKLQCVMARAGVPAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5G3</accession>
    <name>F9W5G3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32950"/>
    <dbReference type="OrthoDB" id="845105at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="366" mass="40274" checksum="866EF3B1437EA9E6" modified="2011-10-19" version="1">MLLPTVCKGLRSPAMIATLYRRVLKQLTLVKRIGACGIVRECCAEYLPDGHAAETGADLLSVTRKAFEAAKLSPASVTKGFDFLKELAETLPELEVLSLWKAYIARGDFDLLEGIAIASTALDVAGGTAEGVAPRVGACAAMVQRTAEHLRRHVTEMKCALVQSGVTPQPPHGSGTATPQLQRVVSLLQERGYGVSEWAPEDHSSITFLRKKRASTVVMNAILALVLHELGLRCAVAGLDLYRPWVRIERPNKPMAFISLAHAGVCTAREVMVMHNSYQPSSLRLEVTPWSGKCRKELLAQMIHKQLALLSCRRFNEPLHERQQQLCRLQLEFLDLQGSHRVAPGPSRASTLNYSHRGELEMSERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5S0</accession>
    <name>F9W5S0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1364</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000756">
        <property type="protein sequence ID" value="CCD12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33950"/>
    <dbReference type="OrthoDB" id="1721119at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18118" checksum="C625CFB9C827D2FE" modified="2011-10-19" version="1">MKIPGSLLRRVGRTRVAPRLIISEPLSCSLALQLVKLTESRTLSSATLVPCDAALQLPGSEEQTAQRLRLQAALSKSRSDGAGCAAPKRAVKRPQQPPTLGANSAMHLNKQLSRRKKESDGSVEGGEPYSNEVAAPAAVPQLPRHAHTDIISVTKTENINPTKDQSIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5W8</accession>
    <name>F9W5W8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1393</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000789">
        <property type="protein sequence ID" value="CCD12571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34380"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25205" checksum="FBA736F410A389B0" modified="2011-10-19" version="1">MTPSTLSYLSFFPNPSLLPQPEGISMSNSPSSPSPEGMAQQDNPWSMEKDVVEVLLKNIGDPKKINLYRFLQPAYPFMHSYVSRFSITDFARNPWRCVGEADGREQVWEQVPRLLWQFRVLALKLTYMQGPRRVGGRGNGRCGGSFSSWMRRTMISWRGWYGQSVKCRHNHVGSWKRRTRLDTRGPFRCRIHRSRGSPYRELFLLICLYPTIFFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Y6</accession>
    <name>F9W5Y6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 1403</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_34550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000800">
        <property type="protein sequence ID" value="CCD12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34550"/>
    <dbReference type="OrthoDB" id="1688692at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388711" evidence="9">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="28546" checksum="D446C6D8B00FFEAA" modified="2011-10-19" version="1">MEMKAGLVWWVMVGVLVLFSKTPRAWEPSRQAIHTEAGESICSLSNKLKDVTPWAQQEISALRKMRDAHASKFLEWQLHFHGSPACKVNESLLEDIRTDLEKVNEEIEKLSEKAIRAGALAAKSAGRLDEFITVFARAKMRSVFDTSNYCLGRRGDPATRTDLFNCFPTGVEIEMGENNLAKIPESVPEKNELDFRTAIEAINHSTFSAHLMVKYGDDNHAGCNLINGKSGILSVALQDRLWWGGGILTIGKASGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Z1</accession>
    <name>F9W5Z1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_34600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000802">
        <property type="protein sequence ID" value="CCD12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34600"/>
    <dbReference type="OrthoDB" id="1673393at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389915" evidence="5">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="320" mass="34624" checksum="9F655DF7713BC179" modified="2011-10-19" version="1">MIWLLVVLGVVCIVSAQSRGTDHNGDAYRALCGVLGSAVKKWLDVKNRSKDDPLHQALAKTIFGKKGQQDLEKLRGALPDDYHVVEGSDSSRGLMCGPPRTAEHVPYQARWPGHSVPHDLLCLCTPGETAWMTTIRGSGAEKLCGKDAQTFVDSEGWADNGYEGGVAQMTTTWLNVTVSCLKGNESAGDLKSVLQKFKDNLGGPVPGHPASLTLGEGDLRDAGACDGTPDGRVCVFYENTTHRFPWWTELEQALATEEEKRYTEKAHKPPSTSRLSSSLATEPKSPDSNASTMPRPERLRSSAPLTQPLLWLPGVASGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Z5</accession>
    <name>F9W5Z5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000805">
        <property type="protein sequence ID" value="CCD12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34640"/>
    <dbReference type="OMA" id="NGNWSEY"/>
    <dbReference type="OrthoDB" id="429638at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016528">
        <property type="entry name" value="VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="PTHR23323:SF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19544" checksum="0EEA1790F9DB067A" modified="2011-10-19" version="1" fragment="single">MSAVWRSFKFFNAELLKSPLCHMELTCCCSGQDLVFAGDSDGMVRVVDRSKSNEGVKYEFRAYRGPVLCMKYVRSRNVLVTIGDDDNEQDVCIVRVWSFAPLVTAGVLPNPPPCNEHRLFSARYPPPKERVPLGAGLNLELTAPSSSKIPESAAECSSAVSVSTFVVSFDVSDDLRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W625</accession>
    <name>F9W625_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1416</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000814">
        <property type="protein sequence ID" value="CCD12628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34900"/>
    <dbReference type="OMA" id="QEYLAYE"/>
    <dbReference type="OrthoDB" id="1330112at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="23933" checksum="C6F777769A16DC48" modified="2011-10-19" version="1">MSGNNANKKYVYGYELYSKNVVQYSSISDIKTIKSAIAANINDYLTHLEVFESSKCCTIGETVSYSLLAGALFAAGFIYLAKDVLLPYSLTTLSLIGITALATLGAYVCDFVQQTDSVAFSATVSPSAHGNKEYISALKGRRVCIRLNDVPNTSKICMEAQLIGPPSLFGAPEVYFSSLNEVPYGRYFSKDGYFFPPALVNDVDKLLNSLKDGIYKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6A1</accession>
    <name>F9W6A1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000841">
        <property type="protein sequence ID" value="CCD12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35630"/>
    <dbReference type="OMA" id="ITETNMP"/>
    <dbReference type="OrthoDB" id="261349at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="783" mass="87949" checksum="7F55612E8185505C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6K2</accession>
    <name>F9W6K2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1483</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000888">
        <property type="protein sequence ID" value="CCD12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36570"/>
    <dbReference type="OMA" id="WPEESSN"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40552" checksum="30ADA092CCC1D837" modified="2011-10-19" version="1">MLDICLIKPKWYVDDTTNKNVKLVRVRSDWPEESSNEPLYEPRNKAVSTYVRGRILRKATENFAKLTISFSELVTTREWCAFKFESSGVLAFTVGSVVTEVVRHLKYLPRKGETKESRTSVLARVGASRLLPTSIHQLCFRDKPVEVVAECLYQPAEENFPVVDGFFLVDAVGSGVSFTEGAVAPIQTIVLIQVTRARDHHTTTSKVEAFRDRMARSFTNWTEMESRLSYEIIYVQHAESTTLTGRQRCARSGVADDAGIEKFWSGIHQFLVKLEAPIAKLILQDIHNVATEEVTCGESDLRYDPEKATDDGGDAVGEAAQTDVTAPDANVTTVVDTDRVEDVTGLAREVRDANITTVALDNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6P5</accession>
    <name>F9W6P5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_36930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000903">
        <property type="protein sequence ID" value="CCD12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394723" evidence="6">
        <location>
            <begin position="21"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="90"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="262"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="583"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="909" mass="102641" checksum="42088C3F83AD4C9E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6W3</accession>
    <name>F9W6W3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 153</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000942">
        <property type="protein sequence ID" value="CCD12920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03820"/>
    <dbReference type="OMA" id="FNCTILP"/>
    <dbReference type="OrthoDB" id="1394271at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="PTHR11960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="SSF55418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="248" mass="27764" checksum="A8851BF858E8CDDC" modified="2011-10-19" version="1">MQTLLKSTPGEPSLFSPPPSRRTQLWGVWEMWCVLPDSHESTCNAVIARGSSSKKAAAPTLKKATWLDRAKSIGLFDSAEGFWGIVTCTLPPSQLPQGFNYYLFRRNIAPMWEHEANRRGGRWIVSFRSHSQENGSAITPGCKDAAGALQPQVDHAWETLCIAMIGEQIPCDETEICGAVVRRTERCNEWKLSLWTRTASDRATQQRIGNFVRDLLHLDGDALQYLSHRELMQATGKSIWDAPQSHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W706</accession>
    <name>F9W706_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1546</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000959">
        <property type="protein sequence ID" value="CCD12964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37830"/>
    <dbReference type="OMA" id="RANEEDN"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="115"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="753" mass="82825" checksum="89EF3831D55AEE85" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W731</accession>
    <name>F9W731_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1555</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000969">
        <property type="protein sequence ID" value="CCD12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38080"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="20020" checksum="350893979A4C0E42" modified="2011-10-19" version="1">MSNSPSSPSPEGMTQENPWSMEKDVVEVLLKGIGKPEGINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W764</accession>
    <name>F9W764_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="112" mass="12839" checksum="5A8CE0CFCB2BF68F" modified="2011-10-19" version="1">MGCASRAPFCLLKYQISTKNVPSSPPTSTLTLYPQYLMRYYIFLRTSLFFFSPFASARWKGAEELLQNIMLRFRSLSWQTLTAQLLHFFFCCLSSCPCAHTSPLATAFDHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7G1</accession>
    <name>F9W7G1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1606</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_39090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001026">
        <property type="protein sequence ID" value="CCD13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39090"/>
    <dbReference type="OrthoDB" id="656281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005318">
        <property type="entry name" value="OM_porin_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34596">
        <property type="entry name" value="PTHR34596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03573">
        <property type="entry name" value="OprD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389965" evidence="2">
        <location>
            <begin position="25"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48597" checksum="DE81D941FC67EC47" modified="2011-10-19" version="1">MNNKSIYGLSLISLGMSMGQVAVAVEQKPEGFIEGSTFSILNRNLYLNRDYRKGQSSPTGNGYSAEWAHGIIGRFESGFTQGTVGFGIDAFAMEGLKLDSGDGRSGARSSVDVLPHNSKGQPEDSYSKVGGAAKVRFLDTVVKVGDVFPSTPVVAYGDSRLLPESFRGATFTNTSIKGLTLQGGRLHAMSQPNSSSMRDGFSTFYAGVVNAPWIAYLGGDYTVNEHVGVSLYTSQFKDVWNQYYAGTTLSYPLSESVSLIGGFNYYRAVDEGEKLLGSFDNKIWSGKTGVKFGAHAVTVGYQRNNGNDDFDYLRQSDSIFLDNSIQYSDFNSPKEQSLQLRYDLDMQAFGIPGLSFMTRYAKGWDADYSNANSVYMRRGADGAPLQDQKRWERDIEAKYVIQSGSLKDMSLRVRQATTRATDFESDLDEVRLIVEYPLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P6</accession>
    <name>F9W7P6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_39880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001061">
        <property type="protein sequence ID" value="CCD13218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39880"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="163"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="506" mass="55834" checksum="5BAC93CE02253249" modified="2011-10-19" version="1" fragment="single">MVLQFVCKKKWPDVRLFTDSWAVANGLAGWSGTWKDHNWKIGEKDIWGRSMWIDLSRWAKDVKIFVSHVNAHQKVTSAEEEFNNQVDKMTRSVDSQPLSPAIPVIAQWAHEQSGHGGRDGGYAWAQQHGLPLTKADLATAAADCQICQQQKPTLSPRYGTIPRGDQPATWWQVDYIGPLPSWKGQRFVLTGVDTYSGYGFAFPARNASAKTTIHGLTECLIYRHGIPHSMASDQGTHFTAREVRQGAHDHGIHWSYHIPHHPEAAGLIERWNGLLKTQLQRQLGGNSLEGWGRVLQKAVYALNQRSIYGTVSPIARIHGSRNQGVENGIVPLTITPSDPLGKFLLPVPITLGSAGLEVLAPERGVLLPGATTNIPLNWKLRLPPGHFGLLMPLNQQAKKGITVLGGVIDPDYHGEIGLPLHNGGKQDYVWSVGDPLGRLLVLPCPVIKVNGKLQQPNPSRMTKDEDPSGMKVWVNPPGKEPRPAEVLAEGEGNTEWVVEEGSYKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7W9</accession>
    <name>F9W7W9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1666</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_40590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001093">
        <property type="protein sequence ID" value="CCD13291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40590"/>
    <dbReference type="OrthoDB" id="1679292at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="317" mass="33518" checksum="64AB3CB8FDF5DCE3" modified="2011-10-19" version="1">MVFSQKSKGNICDVCSHVNKVDQMRCDKCSHIIGRRSYSGSTRNSSKLSTPRKSNHGANQSDEHEAAKGAENDSSVERTTTGVATLFSTAAGKTVSVSESSLRAARMKLGQELCADGSTLTEPPLQESGPGVATLFSTAAGKTVSVSESSLRAARMKLGQELCADDEATVENTAQSESVGVPPPSTPVAGRRAKVSEPPLRSVGEAFPPNDERLLLSGATPAGVTAVAGPNGQSKNVGACLRQLRKPFVVPFAKVAPDTGKAQEAERSSISNTLRAKRRFNDGVTSTKHISFDVCMYRSMPLSSLPSIDDFSMIVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W813</accession>
    <name>F9W813_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001120">
        <property type="protein sequence ID" value="CCD13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41010"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388792" evidence="5">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="87"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="47894" checksum="7A2A5101214DC02C" modified="2011-10-19" version="1">MVIRKFLLVTWLLCVGAGRQCPSSAEFNLFCKLLREANYVMHGPVYVYDEDKDKETLKVMQVLHNATTKNMKEFQKTLWDMKDIFQEHSLPTRPENWEKTHNEIGQLIMEGEKEVDKNRNLAKQVNEKIEAAKLLLAQGIYGDHVMELPKNDGNYMKVLENTSSIFNDENSASKSCGNTQEKAGKTLINDLFCVCVGDADDAQGPCHPNIWPPKSWGYTGSTGNWTQIKYGPDYPTLIPSFNESLHIMEQVCWENMTENNVKSENITALLEQYVSLIGKGNGGVKQNKNIFGHSTRSKNRGQVKECDGQQGNWHHNGPEKKNDKTCVDYTHNLQGKKYDIPWHNKFREAAEKMKEAKTIKVRILKKRAALLLLKTKVWAAYNREKDDETSNLDDVNLSNLLDGTQLPSFSPLLSYLSIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W848</accession>
    <name>F9W848_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1705</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001136">
        <property type="protein sequence ID" value="CCD13375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41320"/>
    <dbReference type="OrthoDB" id="1749197at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17757" checksum="397BF2223357BB96" modified="2011-10-19" version="1">MFCFRCHFTSTSGIFLDVQFSCRYIREGCTDLYMPCISIRPSFLSPVPSNSLNSFLFMLREPFFFFAPTHASFCFVFPFLNRCMLSKPQALVTRCGFSSNFCFLLLLLVSATVTLFLRHMFITFLHTFCTSSCSGSSSLCLRFIFFFLKVLGTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8A6</accession>
    <name>F9W8A6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 172</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001155">
        <property type="protein sequence ID" value="CCD13437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04460"/>
    <dbReference type="OMA" id="HWRVYLP"/>
    <dbReference type="OrthoDB" id="467758at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112401" checksum="35B14860D77C41A1" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8C6</accession>
    <name>F9W8C6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1728</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001162">
        <property type="protein sequence ID" value="CCD13458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42070"/>
    <dbReference type="OMA" id="STTHISM"/>
    <dbReference type="OrthoDB" id="864341at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38257" checksum="46F01D72458BF616" modified="2011-10-19" version="1">MSSDGRFDYTTRVTVLSRTIVYKQQTHPLYKEGPVALKVTASRHSTDTAWHPSLHEANVYKLLGPHPSIPDFVECVEDWFDTDCFQACDARAGRKCVPILVIQFVKAVPLERFLSSVCTIRWSVAMQILRQVVTVLEHVHSKGIVYRDLKLPNLILDRAGHVWLVDYASSIVVGSVDLAGDVTQHIGAPELYRPLSLCDGELSPPRLPFMTDFWAFGAFVLELLTCRPYLGSFSVRSFQLSQCELNEKVIEGVALAKVRYKGVFYDKKPKSNGCCSSKVLWESLTDLLMGLLQVNPADRLGYNGGWADVRGHSFMQNILTDAPTPFPEEYEDEVDELTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8G8</accession>
    <name>F9W8G8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1735</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42460"/>
    <dbReference type="OMA" id="SHANCCK"/>
    <dbReference type="OrthoDB" id="1642672at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="516" mass="56659" checksum="9C28EF881C5211D0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8J1</accession>
    <name>F9W8J1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1736</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001171">
        <property type="protein sequence ID" value="CCD13523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42690"/>
    <dbReference type="OMA" id="MPNNQVS"/>
    <dbReference type="OrthoDB" id="1359770at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="219" mass="24746" checksum="FB432DA1530E89A6" modified="2011-10-19" version="1">MERLRKMAIARIEQQTRNIPPEEVTSIALNDLPFLSERIVAFTSLSHLTLISMRPRIKTLHSLPLATLTSLRMLDVSDNAITVTEEEEGPLPVCPSLRKLFIANNNIKRWEEICRLAVAFPKLEVLDATDNEGNESSRFHEAFELFPNLVAFDLKSKDGKDVTILETDESSSDEEEDESDADNENENEEDEDEEGEEEDGRSSDGNGMEEPPAKLQRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Z8</accession>
    <name>F9W8Z8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 1805</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_44210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001247">
        <property type="protein sequence ID" value="CCD13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44210"/>
    <dbReference type="OMA" id="PSECGDF"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor_I29" evidence="8">
        <location>
            <begin position="120"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="7">
        <location>
            <begin position="205"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="524" mass="57154" checksum="A268A85D42955224" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W918</accession>
    <name>F9W918_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13716" checksum="11DF46F41DF90D5A" modified="2011-10-19" version="1">MHLPTLRLSKWWCAAQQPWRVNQCPLNPVRGYRACPHFSSGWCSRLAGCFKGVLAIAAPKLLSAVALYTMRSPHTPYGGRHPQHFQGIPFTRVTRQHMSSSNVSATTQRCETSLLPKQNDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W989</accession>
    <name>F9W989_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1835</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_44810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001281">
        <property type="protein sequence ID" value="CCD13780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44810"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394787" evidence="4">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="91"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="291" mass="31975" checksum="DAD994DB145AC68B" modified="2011-10-19" version="1" fragment="single">MNMACLVNGIVVFVVVMGSVVSGQLEVDKDDNIEPFSLLCRIYNVAKNPPINYVDLHDPVLIVQEIDALNRSLLEEERLNEEEDMGNSSFPHVKPTLTREAAVAQLSLNQITQKAHTILDEINKVNLNKAIEKANSQFSQVIFGENGNETKLCQATVNDMDNRSQACGMPGEGRKGDSAGKNLVVDFFCLCAMRTKSSEGAKQACGFFVGKIDYYYGWSEQGPWGSSTMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLKTGGVYRWGNGKVEGSNRKEGMLGTGVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9D4</accession>
    <name>F9W9D4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001297">
        <property type="protein sequence ID" value="CCD13834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45300"/>
    <dbReference type="OMA" id="KERTTHG"/>
    <dbReference type="OrthoDB" id="1655621at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="759" mass="80938" checksum="DBBF5414CB3DB6A7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I6</accession>
    <name>F9W9I6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001317">
        <property type="protein sequence ID" value="CCD13888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45780"/>
    <dbReference type="OrthoDB" id="1676204at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390005" evidence="2">
        <location>
            <begin position="20"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="363" mass="39946" checksum="688D8CF8AC305D38" modified="2011-10-19" version="1">MLLLKFVVVLMMTVIPVQSDSEDVDLNATDFRLICDVTGATLVVFNYLNDNEYEDDVHINQLEQEINQLFFGEKGKAHASGFLMFPDEFVETKPSRIKVCGSATSTTRMPSASESLASTFLCLCTRSHLSESNLCGLPLLATNHGGEGESQNVNDIFEQVWGATGNGGIMRNCNGGNTPDSIKVAIEQLNANVTQLESTLKNKNIMLKQSTTCDAKHETPCAHVNKIPAWLQTLKKIQNLTKNMKEPAKKAPAALGKVSENTNTLADTPPTQSPSSPQPEDSAPPEPWREDSKNLEKNNKKELRKAHGENKNAKHVAQLEKKTEIPQNKEEKNEDNNPVLESNEASGSYLSNSKWTLLAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U4</accession>
    <name>F9W9U4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1898</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001350">
        <property type="protein sequence ID" value="CCD13999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46820"/>
    <dbReference type="OMA" id="TIEMLYP"/>
    <dbReference type="OrthoDB" id="125191at199999999"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390044" evidence="1">
        <location>
            <begin position="31"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24907" checksum="2BF9FA31BC3493D1" modified="2011-10-19" version="1">MGTPQHVSVMTMLPPLWLMCVLWGFATATGEDCKDNVTVHVYNLLYSKKIPPSIYVPLIAGFNASVHAGRKRLPAGVSLTLLHPPSLELGVTPGWLSGNVKRLNERDIPIVVGPVGDLPLLTFLPVLNEHNAVAFSPFTGSSTLRVWNKNLYFITASPTAELLALLRYAVTQLRLERLGFMYLQGISFGDEEYRLTVNALSNIGRGLCGLFTVKSSIAGAAPDAELFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA52</accession>
    <name>F9WA52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001394">
        <property type="protein sequence ID" value="CCD14108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47720"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="26061" checksum="FD3CF571A4A5965E" modified="2011-10-19" version="1">MAPQCRPFDLKNILTPNEFLHKHKYDSPLHYPIFPSSLTHPFLPHPEEFTMSQSPSSPSPEGMAQDNTPWSMEKDVVEVLLKGIGDPEKINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH1</accession>
    <name>F9WAH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1972</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001433">
        <property type="protein sequence ID" value="CCD14233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48780"/>
    <dbReference type="OrthoDB" id="1707786at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="23847" checksum="2283EBB5CB5F5C9C" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCGILRVAEWESRGESPMSSARARRLFANWKACLRAAGGGEAGLYGEGSRGFRDPTGDTHNRARECQACHGKGRKFMFQLRRSCCVRLNGVCAQAKNSLTHSICGVPVVEIAVAKDTPSALRDVSCGGGGGLGHPRSSKGRGPNARGLFACRVCKWLLKACASRERHRIGRHGGATLTGDPLCMAALDAAEDAAAERRGGEERVAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAK8</accession>
    <name>F9WAK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1982</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001444">
        <property type="protein sequence ID" value="CCD14278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49180"/>
    <dbReference type="OrthoDB" id="1721269at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17859" checksum="D4D0CDB342C12EAD" modified="2011-10-19" version="1">MPPAMPHAVITTSFDVLAFTPLRYCTIASLTLNHEKSMDRVKKEIRKAMFFSHASGRNICNGARAIEPIHTVIVMMDERMCVLRSVSTVMFRSTESKREAVQCSACAPYTSMVSLNAMSVLPNQLIKSCVKTLSLLAPTNSVRRAKSEMPNPPELRRAQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAL6</accession>
    <name>F9WAL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_07450</name>
        <name evidence="4" type="ORF">TCIL3000_0_49260</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001448">
        <property type="protein sequence ID" value="CCD14286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002034">
        <property type="protein sequence ID" value="CCD15733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07450"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49260"/>
    <dbReference type="OrthoDB" id="1668236at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="44574" checksum="0FF686F1719DB2FE" modified="2011-10-19" version="1">MKREPRTIGKGMLAVVVVVMAMVIGGVVAYPPGSVFNDEEYKALCDVFQASLDLWNASRTSSKKLDNLLEKHLCQALFGKSSGGKVDDFKEILPQEYNDPGYRLYRCGYCDYNTETYPGKSITHDLMCLCTPGKDAEPFYGYYWWIFGYYHKENGFKLCGRLREEMGVDLSHGWYAHKGKHQAKGLENSWKTVTMGCFNGWKNSNKTANQTLEEKVKRLSETLDNFKKKGLKKVNGRYKLGGFDEHNEADGSSEKHIHVRYGTCKYGRRPWWKKLEEVLQGKNPESLLFEHSVNQPAAGQGTGTEDDEEEGGILMEEGKFPSHPGMEEGPTSKTEGAQGVNATQTSVPINSTVIHLNSTRYGTMDGAENYSAQYQMLRSSTSTHPPASWLLCATFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAP6</accession>
    <name>F9WAP6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001465">
        <property type="protein sequence ID" value="CCD14317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05340"/>
    <dbReference type="OMA" id="CCSINCW"/>
    <dbReference type="OrthoDB" id="1668714at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="39302" checksum="9858A4375C8153B0" modified="2011-10-19" version="1">MEWRGAKRTRDETEGEAVAPVVQAPARGEVTTATDAVVRHAAVSHEHAVRPSGRWTLDSPVKEVLLEDCAGLSDMSLHDFLMKHFGETFGSSCVSMRVFMDNPTLCVSDDAVLRRITNSSPYREYELYKTMREGVDRLSAIGIISLRQWKSAAAANEVEDVGAYVRGVLNAALAIAMRVGIAPSGLEIDGAYGAVFNARWSYVVRSDEYSGKWLGMGVLDVAPGQQPHLWSEAQADVPYDPEEPWEGDEVPGVSGKLVMAVLSSQKGWPYMLFSADDVQKEKVKSLTEYDAACDAYIRRENLRVWHIVEKNIDEWLRDRGYVHPFIVIGPRALGIPLQPAPCCSINCWLTRRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAR8</accession>
    <name>F9WAR8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001474">
        <property type="protein sequence ID" value="CCD14339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14538" checksum="036A8168E59B606F" modified="2011-10-19" version="1">MVCGMAGTHSLTCSVISAKHNERKYHRSSASFPLLGHVQGPLPPHTSECRKAIAFTHWVTHVPLKHTTTHFIPSLPLTHGLTLPSLHWPWRVLRSLQSLPLARLSNYNKREMASRPPVTAAHPLGPIAASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAS7</accession>
    <name>F9WAS7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_49780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001479">
        <property type="protein sequence ID" value="CCD14348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49780"/>
    <dbReference type="OrthoDB" id="1676020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390075" evidence="2">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="38386" checksum="337F42FEF543A5F0" modified="2011-10-19" version="1">MMMRLMRVWMVAMLVMLVLGVVANGSGNVDHNGKEHDALCDFLKVAVDKWKEVKTRDPEDPLRKALKNAIFGYESAEEELESWKKTLPQDYKNMEEEGSSRTMWCGQQCQGDHQASYPRWPGHSAPHDMVCLCTKGSQGRPVNNSNNQDTLCGNTRETLGSGNEGWTGNNTGQAQMSATWNNVVTKCLEGGRQKSGNLKEALNTFTGILDHKESHGYSSSKQLGEGTPNEWSACTGSPPRGVCVMYYPEDKDTKTWWVDLQNALIEDDKLQNKRAEEETRKKEEAEQQDSPQMEALKSGHPPTNQTDQHNKSNLTDTMRKLNLTGSSSIILPPSWLLRAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB89</accession>
    <name>F9WB89_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001546">
        <property type="protein sequence ID" value="CCD14520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51280"/>
    <dbReference type="OrthoDB" id="1707754at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21460" checksum="CCFF20199072DDEB" modified="2011-10-19" version="1">MSWYTITSPRTIPWSMEKDVVDVLLEGVTSADHVNLYWFLRPVLACLPVDLVIFTLGDFIRNPRHCIPEVNVCDALWQYLPYLLWKFRLSATPLVKHFGPTETWTKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVWVEAAPALIQVPYAAMGYIVHLPFTPRAWPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC6</accession>
    <name>F9WBC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_51640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001563">
        <property type="protein sequence ID" value="CCD14557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51640"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390097" evidence="4">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="89"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="435" mass="47765" checksum="FAA6916C413EB4FB" modified="2011-10-19" version="1">MACLMNEISVFIFILLGFASGQVEVAKDDNIEPFALLCRIYNVAKNPPINYVDMEEGYKIVEEIDVLNRSLLEEEGLYEKEDAGNNSEAQVKPTVTREAALAQLSLNQIAQKAHTILDEIKKMEITENIEKAKAEFAQVIFGEDGNESDLCNATVKGVGNRSKACGDTGLSSKGSSAGKNLVVDFFCLCVQRQDGGGINQVCGFYAGSGYKNGQLGWNETGPWGSSTMWASIKGGCGKHMQQHPKTTSEARHILDQFLKHLKVGGVYRQIKCENDPPCSNRKAKIVVSGSDRKAGMLGTAITVSISTEVTCHGKKGDEKTGKTPGGVCVYYGQESEWKNIPWVIKFETALASVDAVNNQKTSIHRVIKRLQMLLHRAEEIYETTKVMLEIQKPVGLPAALQNASGNLTVYNATRIRSYSYNLNSYFVPAWALLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBK4</accession>
    <name>F9WBK4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001591">
        <property type="protein sequence ID" value="CCD14637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16479" checksum="68DA7797E8E4D4A5" modified="2011-10-19" version="1">MFSWSAFCDLAISAATHSPSWINGTDPFPISLPRDGACPLKPIKAHLRAESGILRIPFAIGARDINSRHSGWQTSHLLLYIEIEWMLDLCAVVMARAWQMPRCDVLSWIRVKQGCAVSLFGGFAYLSIRLGNKFLTFCFHFGGMLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU6</accession>
    <name>F9WBU6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 2145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_53250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.072"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53250"/>
    <dbReference type="OMA" id="PRGKNFC"/>
    <dbReference type="OrthoDB" id="1275401at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021981">
        <property type="entry name" value="DUF3586"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12131">
        <property type="entry name" value="DUF3586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="7">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="6">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48019" checksum="E1AD321A7643F20C" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGKAPEAVDWRKKGAVTPVKDQGACGSCWAFSAIGNIEGQWKVAGHELTSLSEQMLVSCDTTDYGCRGGLMDKSLQWIVSSNKGNVFTAQSYPYASGGGKMPPCNKSGKVVGAKISGHINLPKDENAIAEWLAKNGPVAIAVDATSFLGYKGGVLTSCISKGLDHDVLLVGYNDTSKPPYWIIKNSWSKGWGEEGYIRIEKGTNQCLMKNYARSAVVSGPPPPPPASTFTQEFCEGAECQSGCTKATFPTGKCVQFGGAGSVIASCGSNNLTQIVYPLSSSCSGFSIPLTVPLDKCLPIVVGSVMYECSDRAPTESARLVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBU8</accession>
    <name>F9WBU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13423" checksum="42553269A2D306B2" modified="2011-10-19" version="1">MNSLAMSVFSDTRYWCVFSHRARCSSPAASPDEQHFQRLLIDPLSTCWSFMISQLQAFSTFSRHSNAFPMHWRNLRTVVLLVWCSFALVTCSRTIVLGPTPSTTKEPSTRGKFGMRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC07</accession>
    <name>F9WC07_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001650">
        <property type="protein sequence ID" value="CCD14794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53800"/>
    <dbReference type="OrthoDB" id="602576at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="48348" checksum="C5BC97E2099317B8" modified="2011-10-19" version="1">MDYGTGSLSCSGVVEAISLPSGSQLKDFPSAVRKEMQRIAVALLRRLLYPIMCRRMAQSYRNQTVKKLGDTGRFGSVLVKTLRQRSSLGSAMRRKKFLEDLDDRNPCVKALKESVTYRLYLKDEFIQYRGEPPNAVVFVVKGSIRRCATIEKVKKKRAALPKFSFSTEEMLASEYGSTQSCLCSVAADSGLNIQSEPTGAEKKTVLTAPVMVGEYCTVGNFPCPEYLVADSQFVIIGWIPKSAYCALLEALSQGIQRSILTRALKARERELPNYAPMTLSRMRMCPLLAQLGDDKVSTLMSQLVPQVCPAGVQIDGSSVQKHIYFIRRGVVYLQQDESTSQKNFCPSMPMSRSFYMEGHTFGERQCIFREALNSSFYTLVNVDLYLLPFSCVTQMMESNIDIRTQKYRSCQAVLCKASKISTKGMALFPPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC20</accession>
    <name>F9WC20_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001654">
        <property type="protein sequence ID" value="CCD14807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390131" evidence="1">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="15871" checksum="3A093261DFEEA705" modified="2011-10-19" version="1">MDTCFSLILLFSTFIAAVLYGEHAEPCDCPPSIPTAEVTARVPSRGMATLLVSEAVRCRIRVYMCMGVLHLPFSLLIFTCHCIPSCVNGLFLVLMPRPVLSHFSAPMSVVLSAAQSRRRGRGVEGQDEVPQSMCHSLAATDEGFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC67</accession>
    <name>F9WC67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05680</name>
        <name evidence="1" type="ORF">TCIL3000_9_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575322">
        <property type="protein sequence ID" value="CCC92832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001676">
        <property type="protein sequence ID" value="CCD14859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC92832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="106" mass="11292" checksum="E2DC2A95DDF7265C" modified="2011-10-19" version="1">MAGCSGEPDLIPLQWAGSLTRAPQARYIASLRGGKEYFAPGGMNWLEIIIKLCTHMSTGSVIIWRSGSLRGGCGELISADESKRASTGAAPGKQETFAELKSAYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCB9</accession>
    <name>F9WCB9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_05730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001698">
        <property type="protein sequence ID" value="CCD14912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05730"/>
    <dbReference type="OrthoDB" id="1319375at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390145" evidence="3">
        <location>
            <begin position="26"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="462" mass="50114" checksum="C59370AED8494E2C" modified="2011-10-19" version="1" fragment="single">MPGALRRVLLAVSFVALLGAVPATAFGQGTFECDTVWDGPNADNNLEECVLNVSRMLSQWTLFIIPFLNALILAVLVVGFPITLILSICCNCCHCCGPNCCKPETAKSQDRARCCLWLYIFYALIWSVMMFFLIIYGSQAIMKGAPQLVDDTISGPLVYFNHTVEAVMDYTYDWSSGERKEPAEFSIDLSEFTLLQEKILDIAELVRTSVFSQFDKAVIASYVIGSLGFVMVLLILPFAKFRCCIPGFPMSISVVYWVFGVVFGALGLLVSILAYFSTLTCGEVAQHFDRDPGVIQWYGVPVCKQSFDFHKLNTDIMDAEEHLSQGVCGTLLPFCDNGKPLLFKGNPFRLPVGPNGVAGLPNSQSSPPFRSHTEPFVSPGSQLPGSRSPARVASSRSTVKSSQISHSTTMSGGGTAGSPASVKLGDIPDVGKLPDLPNTPILNCGGEITEPSQCRTFDAMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCG3</accession>
    <name>F9WCG3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001719">
        <property type="protein sequence ID" value="CCD14956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17394" checksum="FCD1A50C0D4BC061" modified="2011-10-19" version="1">MNSSGANHQHTYLYIYFYVESCFISTRSPLTLTSFNRALRRPIFFSCLSVELRVVVLFSTRAKNFLDFYIIILPTALWESHYFTCDVEISCVSIYFLFALPCSTCVACCFVPHPRTHTHHFCSFSFLLICCTNLFCDTWPKFIRFGTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCK8</accession>
    <name>F9WCK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_55680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001736">
        <property type="protein sequence ID" value="CCD15002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55680"/>
    <dbReference type="OrthoDB" id="1663239at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394873" evidence="5">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="97"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="425" mass="46346" checksum="72C27DE3A1F6A68B" modified="2011-10-19" version="1">MVFSMNVMAFVIFSLVGVARGQIEVAKDDNIEPFSLLCRIYNVAKNPPINYVDLQEANRIVEEIDALNKSLLEEKGHGEEEDAGNNSEASVKPIVTRETALAQLSLNQITQKAHKILGDIAKINVAEEFGKAKADFNKVIFGDGGNEDDLCHATVKGVENRSKACGDTGEGKKGTHAGNNLVVDFFCLCTQMMDKEGVNQVCGFYVGSNSNHGLIGWNDSVLMGSSTMWASIKGGCGKHMQQHPMSTEEARHILDQFLKHLKTGGVYRWGNSGDKVEGSERKEGMLGTAVGKKDDNNGKGLICDGKKGKGSTPAGICVYYGAELNSWEGNIPWLKQFKTALTSVDAVNNQITSIQRALQKLQMLQHRAEEIYETGKVISEIQKPVGLPAALQNVSGNLTAYNTTRIRSYGYNTNSYFFPALVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCM6</accession>
    <name>F9WCM6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_55860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001739">
        <property type="protein sequence ID" value="CCD15020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55860"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390151" evidence="5">
        <location>
            <begin position="24"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="104"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="423" mass="46401" checksum="192E616FF4F889CC" modified="2011-10-19" version="1">MVCFVNVLLAAVVICSFLSNVMGNNAVVQNNDNSEQFALLCRIYNVAKNPPINLVDLQEPLNIVKDIDVINDSLTEEKQFNETENVGNSSDAQVKPTITREVSVAQAILSRITQKAHRILEDIKEINATSDIEKVKDEFDHVIFGEGGNESHLCYGALSGVNRREDSCGKSGLSNKGDSAGNNLVVDFFCLCAMRTKDGEGIGNVCGVEIGGKGERREKPDSHGWGDEAPLGSSSMWASVKKGCGRLMHQHPKSTKEGHDSLKDFLKHLKTGGVIRNDPKEESDLKKGMLGTSVPNKGSTRDSGPVCNGKKGNGRNGSPGGVCVYYGTESDWQNIPWMMKLKNALNTVDTINNKTTTIQRAIKKLHTLLHRAEEIYETTKVITKARNPVASPNLQTAAKRLTAYNAAWRHHIYTHFILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ4</accession>
    <name>F9WCQ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_56150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56150"/>
    <dbReference type="OrthoDB" id="1671879at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390178" evidence="10">
        <location>
            <begin position="26"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="17"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43191" checksum="5935BABEAEE478A0" modified="2011-10-19" version="1">MALELCSKWWWIIALSMLLAEETLGTGPKAIPTKAGEAICTLSKTLKDITPWATQQVEDGAAKITHLEMKLLEWQTKFIHSKPKGSGSEACKITGLLFRQVRKEIDKTREEVEKLEKEASKAAAFAANSAGRLDEFITVFANAQGSSKYCLGDDKAAKPEELKDCFSGTDFGEESLVDISERASEQEPNLDTNIDSIKHSKLSSHFTGYSSTTEAGCNLVKGTKKGILENTELEKSLWWGGGILTIGKAFGGEFNGSFIPGEIPAATKDKATWTADPATQVVHLKNASDTFKAFKAVQEKVKEKIESIEQKIQACLGGQESGENGTEQNATEPTVTTEQTPTSSTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSAYNAKIPFIHFGFLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS2</accession>
    <name>F9WCS2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2260</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001753">
        <property type="protein sequence ID" value="CCD15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56340"/>
    <dbReference type="OrthoDB" id="1667601at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="381" mass="44323" checksum="9D15106856803742" modified="2011-10-19" version="1">MQIGYGGDESEWTMETKAEDVLLARSRDLYGVSAYDFLVTYYNNAYGLDPENFVSLAEFLNRPSDYVKDEKQRKDVMSSMQYKVARLDVCMLENICSMQRQGIRTLNDWACQQCSVNVDRITKGILTRAVKQVLQSTTKQGSTQNNCLTHHTFLRHSLLTFMHGRLLSRVLARLSRLPRQGSDTNGRESVLQKTGEDLMPYVPSRVLCYFPEGVERRDLEHGKLYVPKPPFPIADAFFFVKEKNARHTNILLIKVVTEVTLQPLQMNESVVQAFWERMSKIFKFWDCFASLADWEIIYIHSSSDTLLPQSVEMEHASRLQKDNSQEFNISFWDDIQQYQIVLDADRIHEIYGENMKFPFGEATLPYSEILFEHWWSIVTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCX5</accession>
    <name>F9WCX5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1972</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2288</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48760</name>
        <name evidence="2" type="ORF">TCIL3000_0_56830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001433">
        <property type="protein sequence ID" value="CCD14231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001784">
        <property type="protein sequence ID" value="CCD15123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48760"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56830"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16533" checksum="654865CC5D618372" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTHAPCRGQKPQCGQQLLHAFGLHHVPRVLGCAWCSAVVVTLACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD21</accession>
    <name>F9WD21_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001808">
        <property type="protein sequence ID" value="CCD15169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57200"/>
    <dbReference type="OrthoDB" id="102510at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="369" mass="39921" checksum="C40B8B765CB7DBB4" modified="2011-10-19" version="1">MTFSGVGSCAASAVDTCSKWTPWIDGILSGFTPSALAVLTCTLTHMDDGEAVDTFMPWVLLRLRPAVKDLFPIDTVHLMAALLANFSKAASLAAESSNHPQWLATHSNCNLLHVVYDTCRGLFLQMYGEEDQKSSGDGANRPCRKDWSPKTRASVASVPSRHFAEILVALCRAGVRDEAVAKACAGRVTPRCCMMLPIAQLVDVTLALCFHFHPRSLDMEETNLVGDVGVMEAGEGVPLPVKSQPTSGRCDTDVAQEATQCKKLLPPALNALWGRVEELRPSQVDALVRCLRHYYGEKVDVDFLSRLQKHTAVIKGMKGDTQQQQSEEQSSGGCTTVSDAAKSPGAATKKEPEAMGSQYQLSAEDLFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDD6</accession>
    <name>F9WDD6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2356</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001860">
        <property type="protein sequence ID" value="CCD15289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58200"/>
    <dbReference type="OMA" id="NIESDWK"/>
    <dbReference type="OrthoDB" id="1665319at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="406" mass="46728" checksum="8DA70A028BB19830" modified="2011-10-19" version="1">MVRRGVKGYIIFDISGNSVHIGDLPYAWAIVLISSPNVKKFHEFAKRRQDTLPIYMNCYEDAEFKAALVWERHWKVVNNQKRFEDVNIESDWKVLKERIDMVGPLPRYVLAGQATFEKRVSEVETALRLMRDELGYYMRVLDNPHEWHEDGTTHKLVKLVRCEVKGKVECRNRVTSIYVLKELARKLRAAHLKVNLIYHILCGALEKCAVLLEELSLDIFTLREAVDTLVKHLEHLPRGNEAKRESVLCQRGANGRVPTALSEFASDGPKQKLVTGRIYKPLATNFPLVDGFFVVENVGLKTIVLVQVTKAKEHHTKKTTVNAFREYMGKVFEDWENIEKAYTWELIYVQHVDSTAIKRRQRCASSGDAANDTDLALWDRIHQYQVTLSSDIAAEFINRSGDTRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDF4</accession>
    <name>F9WDF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58380"/>
    <dbReference type="OrthoDB" id="1673531at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389009" evidence="5">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="47"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38796" checksum="D6DBAEED8C4F26C6" modified="2011-10-19" version="1">MLKLWMVVSVLGVGMVYVYGDKKNHNGDEHVLLCKVLKAAVFSHKRNSGSKDLKRALHITIFGSENGGDLETLKGTLSGDYDVPNGRNRASVCGQPHNGVSRTGKPPRWPGHSAPHDLLCLCTPGQEWWPLSIGNEMKELCGESKGALKADTVEGWGTISRPSGVVNGKEILTATWNTVTKKCLENDGQEGDLKDALKKFIAKLNHTEASTYKDKYLLGEGDFNSYPCGGNEKLCVMYYNSTKYEHIMPWWTVLEKATQAEVQKQEKKKDNKAENLKQKAQKQQQIQNQEHSQPQHTPRTAALKSTKQVTTEADKNNPENISAPIVTLEDTNGTIIAQSFPWLLSAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDM6</accession>
    <name>F9WDM6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001889">
        <property type="protein sequence ID" value="CCD15380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59060"/>
    <dbReference type="OrthoDB" id="1730551at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16851" checksum="60DB42E58BEDA701" modified="2011-10-19" version="1">MHRTHAHTPGTSSDAGCTHTHGRVQQQDTHCASATQHVMHLPHGEETKAGKPTHMFSFVYFQYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVYREAHTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDY5</accession>
    <name>F9WDY5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2421</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001932">
        <property type="protein sequence ID" value="CCD15490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60070"/>
    <dbReference type="OMA" id="VWHITAN"/>
    <dbReference type="OrthoDB" id="1269884at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="SSF47370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="39069" checksum="D14E3A9F7B0F6667" modified="2011-10-19" version="1">MRHSDVLQALMVRLVDPEKEDHDWLLISSVFYSLTKLLLPAPRVRQLYYSYLQAYGSRPAMEAACVVFAQQLSEKLQRSINSTAAPTVTGICRTGVNSSPMTAEISTAGAALSSGSCELVGMTRAAVQSRSPVQDEAVWSDSGFWEPGVAASKLTPEQRERWRRLRHEPISPDILVELLQRFTLVDGAAVFLAPVSSSTVMEFNGVRSGPYATIIHRPLSLLCIKRRVLAARRNYEMHKHQANMYPQATPIGGPSDPRRHAHNSDAVPLEIQTAGKKNNFRPPGADADDNQAIRTLQELEQAIWHITANCVTFNAPESYYPFMARKFALACVGIIDEYSLQCVSSPCSAALHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE27</accession>
    <name>F9WE27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13658" checksum="CED527B62C28DBD6" modified="2011-10-19" version="1">MPACPEEHPAYPPIRESQLYWKMPGFNFITVRLTLAPVSQRRTARVVASCLPTGRALVLDSQLGRPGSPRYPRRFLQLTDWDLPSPIGDFHKVHKNTQPVCCCPLAIHRCFLRLDSALTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI6</accession>
    <name>F9WEI6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 271</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002016">
        <property type="protein sequence ID" value="CCD15696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07100"/>
    <dbReference type="OrthoDB" id="1180930at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="2">
        <location>
            <begin position="70"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20653" checksum="935D77F4EDD9CDA4" modified="2011-10-19" version="1" fragment="single">MLQAAYRDCSLWYAAVASAACGYLAYKCVKLLRIIRGRVTEQMMLDDLQHGVVHLFIHPRWPHGPNYFLHCLKVETFLRLAKVSYIVYLTTNSSLSPNGKLPFIVYDNVKIGGSEAILHYLTNEFHANLDNDLSDEDHAVGRAVTRMVETSLNYGLQRLLLINQPEVLEVMLEDGLGQSERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEJ8</accession>
    <name>F9WEJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 279</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_07210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002025">
        <property type="protein sequence ID" value="CCD15708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07210"/>
    <dbReference type="OrthoDB" id="1727325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390256" evidence="2">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="26553" checksum="13AF00572EC63447" modified="2011-10-19" version="1">MTTTMSRVLHLMTVTLLCARVGMGQASDDDDCGGQSIPQKVEGVQTMCDVARQLRALETASQSAVAAVVSSARDASEAKERAEKAVERAKSKKRGVDTATEAAARAAAAAQRAETVVSDARKHAADLTAASKDAIETTDESLRLLATCEKADEPIRTAAKKCTGAAAEVTSKSLESAFDALAELLPDGADDIREHGAVFVKGLKSLEDDVRTAGEAKNEAEKAEGDANDAADGARAVLTGVCVLLLLAALHFSAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEP7</accession>
    <name>F9WEP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 300</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002048">
        <property type="protein sequence ID" value="CCD15759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07700"/>
    <dbReference type="OrthoDB" id="1687413at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="259" mass="28264" checksum="2BF0D0605E185917" modified="2011-10-19" version="1">MVFANAQGGTDLMGKVNYCLGVGGRPARRRDLSDCFPEGNKLEIGETNLAKIPESTTHNNEPYLTDIMEDVRHSSLASYFNRKYGGDGESDCNMINGSGGILSSALRDNLWWGGGILTIGKGFTGSLSSKENFIAGEIKDAKEANKAFWTGLPTTVPHLNKTLTAFQAFKDAAATITQKFTEIEKIEKQIEPCLSNETMEEGPTQSCFKSAVKLNAELQAANALLARYFEEKGPLPPEGALILHQSVVNVWYLFTAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ1</accession>
    <name>F9WEQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002049">
        <property type="protein sequence ID" value="CCD15765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="104" mass="12038" checksum="3EFFE0C8A0707FB0" modified="2011-10-19" version="1">MFFCHDTSWCIIPLNLFVTITTDHVIHIPFTIFSTLIIYQWKNHDEGYGNKGPCIMLTRSSTACSHEKEDEAANIDEFNVSNIFDWVTVPTSFSFPYPLKNIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEZ4</accession>
    <name>F9WEZ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 330</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002081">
        <property type="protein sequence ID" value="CCD15860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08570"/>
    <dbReference type="OrthoDB" id="1699493at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="21625" checksum="951B15FB285680FF" modified="2011-10-19" version="1">MDFFLPTRPLGIKKGKKIKQEALDTFGGFACPPLCDASRRIRIHMAQFTCGLNYKIKKEKTKFAESYPNCFCVPLTWLYVCRMINMPELSFCIVWIHDVSRCYAYFCSGAPLRITLGVHLLGVWSGIILNVFLRVHTHPDRGYCLMSLFQTWAFSVELIANGSTARGEGNCSHRKLQDLSLLCAGADSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF33</accession>
    <name>F9WF33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 343</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002096">
        <property type="protein sequence ID" value="CCD15901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08930"/>
    <dbReference type="OrthoDB" id="1127693at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="22856" checksum="9CBEAC1E9A360B75" modified="2011-10-19" version="1" fragment="single">MPPKRSRGPEGIIDKKVPSILEVRVQPGASVNEPVGVRIGHTSYVNLSSGLLHVIGGCDVASLPEVLLVTQGTKSKTPIPLVETWDVTSRKWLTGKSEEENDSEMEEGQVNETPLADSFLPNDTQGRFSPADTCTTLLSGGPNDIVWPTLAGLQLYWKPIQGDGSIKSKPTLAVSPRGVCINSQGPDEKGKMWLAEGSSTATQSTSTGFTDTAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF76</accession>
    <name>F9WF76_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 357</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002112">
        <property type="protein sequence ID" value="CCD15944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09300"/>
    <dbReference type="OrthoDB" id="1708282at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394975" evidence="1">
        <location>
            <begin position="21"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="221" mass="24820" checksum="F6E37BB7FA57C8B1" modified="2011-10-19" version="1">MDITCFLNFSFLSFSFSVSAHSRSLFLTMCFRSFRFTSAPSYPPINKYRAVQSRHKLTIIIIIRANTVGSHSRKRQCSFTQFTQKRKKTCKNSPSFVLVLSLHPSHFCSSSPRDDYSTLRPCAGVGFRMKSEVVENNAGRVEETPSLTSVAEDSPLLPSADFCGLIKLRRGVVNDVAKMLRPVRDSRARCEVRLLPKPHRTCAGGCPLPSLNSLWSPSPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG4</accession>
    <name>F9WFG4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pex24p domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002141">
        <property type="protein sequence ID" value="CCD16032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16986at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016043">
        <property type="term" value="P:cellular component organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="Peroxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pex24p" evidence="1">
        <location>
            <begin position="31"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="14280" checksum="A37192C760DE994B" modified="2011-10-19" version="1">MRSASSDLKSLDIMSEGSVERDVSDGPRDTCRVVELYEYEAKVKLFGWTSHFLPHGCAPWCDAEGRRAPRKSDYVLPQGWVWASEWVRLREGTDRDGWEYVGKKDSVTELRRRCWRRKVRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM7</accession>
    <name>F9WFM7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002164">
        <property type="protein sequence ID" value="CCD16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10600"/>
    <dbReference type="OMA" id="HIVFACL"/>
    <dbReference type="OrthoDB" id="1821786at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389066" evidence="2">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="281" mass="24554" checksum="83CE2498510363D5" modified="2011-10-19" version="1">MKTQVVFWKASTALALILAMSLGGCSSGGGGHKSSVAASSPDAGAGAGGGTGGGDGGTGGGTGGGTGGGDGGTGGGTGGGTGGGDGGTGGGTGGGTDGGDGGTGGGTGGGTGGGTGGGDGGTGGGTGGGTGGGTGGGTGGGTGGGTGGGTGGGTGSTTTPLVTGQIAGTLGTTVGNVGTAVGNLCSTLNGVPIVGATAGGLVTSAGTAVNSIGTGVTAGLGSLGTNTNSLGTTVAGVGNGVVRLGRRHLDHRPNTVNHSRRNTCGRRRDRRSGHCGRWRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFX5</accession>
    <name>F9WFX5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002196">
        <property type="protein sequence ID" value="CCD16205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01390"/>
    <dbReference type="OMA" id="MNSTEYN"/>
    <dbReference type="OrthoDB" id="1497361at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23811" checksum="B7C6301AC3AF96D6" modified="2011-10-19" version="1">MMFGSEPPLYLKPIGRRGLRRHEADELQHYPNYVHPMCQQPDSAAYACEAYRLHPSIKAVHELRHQHDEARKAKENVLRGRVMRRIRRDEELRDRREREYERQEQHNENITGLSRRNEPGNGLDTVTMQCRTVEARQAMEHKRAVDEHLYFRRQKYLVERSNGHGFNIITGEPLKPVVVPPLPEVAPVGEGSRKSASRFTEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG09</accession>
    <name>F9WG09_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_11870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002212">
        <property type="protein sequence ID" value="CCD16239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11870"/>
    <dbReference type="OrthoDB" id="1668988at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395006" evidence="10">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD16239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43234" checksum="9F404302B5E722B1" modified="2011-10-19" version="1">MVMELRINWWWLVASSVFMAWSSAFGEGNAPKAIPTKAGAAICTLSKTLKDVTPWATQQVEEGSAKVTNLEMKLLEWQTKWVQSKAQGKGSETCKMTGLLFRQVRKEIDNVREEVERLEREASKAAAFAANSAGRLDEFITVFANAQGSSNYCLGDTNAAKPEDLRDCFSKTDFSEESLVDIGERASAQEPNLFSRIESIKYSFLSSHFTAGSGGGCNLVKGASGGILGKTDLEKSLWWGGGILTIGKAFDGVLNRENFTAGEIRNAENGGSKAFWTADPATQIVHLKNTSDAFKAFKAVKEKIQEKVKSIEDKMEGCLTGQEPGQNKTEPNATEPTTTTEETTTSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPTTRFLGLLTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG71</accession>
    <name>F9WG71_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_12450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002240">
        <property type="protein sequence ID" value="CCD16305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12450"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390298" evidence="5">
        <location>
            <begin position="20"/>
            <end position="383"/>
        </location>
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        <location>
            <begin position="40"/>
            <end position="246"/>
        </location>
    </feature>
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            <end position="262"/>
        </location>
    </feature>
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            <begin position="280"/>
            <end position="358"/>
        </location>
    </feature>
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            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
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            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
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            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD16305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="383" mass="42462" checksum="1A98D487EC274C3E" modified="2011-10-19" version="1">MKMVIVVVMMVVVVSQVSGFNLEETNLLCSVLRAGERVLNSTAVNDKLKKDIKDTLYGTNDGVHFDKKGKVTIRGRCFTQGLRSPLCTYRRNLGCFAASVVGTFTCICTPGTAVRGGKLCGESDWNGQTWSGNTVRLAETTTLFQDVWEKIIKRCLAGKDNMQNDKDELETLQDAVRRVRDNLHEAGGFFYLGGNEGGGCIVNNRFPQGICAAYEKRQNRDKNNVTIPWADKIQKAVENAKRALQQPASQTIYSNTDPTTVSQETTIPAKVIERTIESGANEQLSASEKQSLQDSPTSSEALQNPSAEGREHIPHQPLTEEKTLTRRKRDAAITNPENIQSDEQRTQDAHTDKEKKNDEFIFSPLTSGSKIINMECLLLPALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002258">
        <property type="protein sequence ID" value="CCD16362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13000"/>
    <dbReference type="OMA" id="CWISALA"/>
    <dbReference type="OrthoDB" id="1151754at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Atg6/Beclin_C_sf"/>
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            <end position="817"/>
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    </feature>
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        <location>
            <begin position="582"/>
            <end position="599"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="837" mass="90941" checksum="1AE86CF284EC2647" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGH0</accession>
    <name>F9WGH0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 500</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">TCIL3000_0_13300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002270">
        <property type="protein sequence ID" value="CCD16406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13300"/>
    <dbReference type="OMA" id="ANVSMKK"/>
    <dbReference type="OrthoDB" id="1653468at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="1957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1689"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1773"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1970" mass="220815" checksum="8D79D5012389BBCD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGP1</accession>
    <name>F9WGP1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 524</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13970"/>
    <dbReference type="OMA" id="VGHETEG"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="66"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="470" mass="49760" checksum="B0BB30C9ABD60DB4" modified="2011-10-19" version="1">MSSAAPNPVPAGTEPVELTAVGCKGNDEQRHDTNPTPKPEDSKENVGCFAKVAAFVAATIPPGGIAASAFNIGSTTVGAGIFGLPAASQSSGLVMAMFYLLVITAMAVFSTYALGVAADRSKVNTYEGVARVLLGKWGAYITAAARVFMSLSGCVAYVISTGDILHAILKNSSASDFLKTTAGNRLLTFIMWLCCMLPLVIPRHIDSLRHASTVAFVLMIYMVAVVVVHSCMNGLPENIKSVSVGRNESAEVVLFNSGNTAIEGLGVFIFAYVFQVTAYEVYMDMKDRSVRKLVIATIIAMAMCLPMYALTALFGYLDFGSKATSSILLMYDPLNEPEVLIGYVGVLVMLFVSYALLGMSCRNALYSLIGWDANTVAFWKHCIAVVSLSVVMLVCGLFIPKINTVLGFAGSISGAFLAFIFPALFLMYSGGFTLQKVGPLCYIATYVLLLSGIIAAVFGTGATIYGVVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN0</accession>
    <name>F9WHN0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002464">
        <property type="protein sequence ID" value="CCD16823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="16083" checksum="367A5BEC5C2490E6" modified="2011-10-19" version="1">MVATPYFFEIYSDNFLFTERSIYTFLILQPAQIFLSLVSPSTQTEDRRGKAVFWRWHPFRVTRAFCVTANFTSSPFDFLKCFGKSEMLTYCALSFSPKDISSTFLFSFFSSFSSLRQSLLPAKVCHTDVVAPITLQSISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN6</accession>
    <name>F9WHN6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 67</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_01890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002464">
        <property type="protein sequence ID" value="CCD16830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01890"/>
    <dbReference type="OrthoDB" id="1669301at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="94"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="351" mass="38850" checksum="8EF9D32FA728C36A" modified="2011-10-19" version="1">MVVRGDCYNRDAFNELCEITRNTSTLLRLHGDYGPLKESIYGTKGRIALFTEDGKVDSPWGCTSGISGRSVYCNHYAGNPGFAWSFGRNGCFAESLVGAMVCICAPGKAGPTNLCGVSDVGSGKRWSGNFNGGRIDNALLKDLWLKVIKNCTEGNKSEQGYAEEFEYLKEYLKNIRRKIHKGSGFFYFGGENGKTVCGAEKAEDVCARYQGRNDNEANIPWADKIEKALEQMKPAIYQSRARRTLVQATKVPSAQRSNGKPVELEEVAKVKEPVVQTEATSQKTDEQPDGKESQTENIRSPSTPEQTPYKRTKRNTQTTPLSDMPHLATDVNNESSLMTKPLWLLLVAILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHY7</accession>
    <name>F9WHY7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">T. congolense-specific, putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002500">
        <property type="protein sequence ID" value="CCD16932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18140"/>
    <dbReference type="OrthoDB" id="1722755at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16316" checksum="35791B05191CF1E2" modified="2011-10-19" version="1">MSQFSCSPITGSREKTKFAESYSNCFCVPLTWLYVSRMINMPELSFCIVWIHDVSRCYAYFCSGAPLRIALGVHLSGVWSGIILNVFLRVRTHPDRGYGLMSLFQTWAFSVELIANGSTARGEGNCSHRKLQDLSLLCAGADSQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI26</accession>
    <name>F9WI26_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002519">
        <property type="protein sequence ID" value="CCD16971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18430"/>
    <dbReference type="OMA" id="CAFEEMI"/>
    <dbReference type="OrthoDB" id="1719298at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="520" mass="50362" checksum="820161D64CD4E35E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI67</accession>
    <name>F9WI67_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 736</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002533">
        <property type="protein sequence ID" value="CCD17012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18740"/>
    <dbReference type="OrthoDB" id="1707208at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389164" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19950" checksum="26407DBBDF5646BA" modified="2011-10-19" version="1">MPQPRRSLVLITSSVLWVEEGNALCVGERAGLGIIVKLHINSNRGVYYWERGLLRVTTTAEVGEASEKHPSRTSRHLAEAYGICSLVCADSPGDGGYLDMVPEYCSRPLGGSQAPALLPVQQDWRRYEARGYQRSRQHKWHCGSDGVVRLPLCTLDVLYFKCSDFSCFLARMSSKDLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI84</accession>
    <name>F9WI84_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002543">
        <property type="protein sequence ID" value="CCD17029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02090"/>
    <dbReference type="OrthoDB" id="1701328at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21232" checksum="C5E5B920CB3EADF1" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVDVPLEGVASPDHVNLYWFLRPVLDCLPVDLVCFTLGDFVRNPRHCIPEANVCDALWQYLPYLLRKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPCQGVVVVEATASFVQVPYSTVGYLVHMPVTPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII4</accession>
    <name>F9WII4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 798</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002601">
        <property type="protein sequence ID" value="CCD17132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19790"/>
    <dbReference type="OMA" id="GDILVWC"/>
    <dbReference type="OrthoDB" id="796813at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="781" mass="87052" checksum="8E9B08F77891DC65" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIL6</accession>
    <name>F9WIL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 812</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002616">
        <property type="protein sequence ID" value="CCD17164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20090"/>
    <dbReference type="OMA" id="NEMFANR"/>
    <dbReference type="OrthoDB" id="1235716at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="888" mass="97524" checksum="2E40F479EB939EAC" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIR3</accession>
    <name>F9WIR3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 824</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_20480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002629">
        <property type="protein sequence ID" value="CCD17211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20480"/>
    <dbReference type="OrthoDB" id="371693at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="271" mass="29596" checksum="A1C50E32EB9E7C27" modified="2011-10-19" version="1" fragment="single">MTDYKIRDISLAEWGRRALELAENEMAGLMELRREYGPSKPLKGAKIAGCLHMTVKTAVLIETLVELGAEVRWASCNIFSTQDHAAAAIAKRGIPVFAWKGETEEEYMWCIKQTLKGFSGDGFPNMLVDDGGDLTNYVLDECSELVDKIYGVSEQTTTGAHNLYKRLQKGKLPIPAINVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKTACVCGYGDVGKGCAASLHGCGAPLLVTKVDPINPLQAAMEGIRCCLSRHRERSAHFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ0</accession>
    <name>F9WIZ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 852</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002661">
        <property type="protein sequence ID" value="CCD17291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FTYCLEL"/>
    <dbReference type="OrthoDB" id="481745at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013039656" evidence="1">
        <location>
            <begin position="16"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="819" mass="93910" checksum="23A92D4F8760644B" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ19</accession>
    <name>F9WJ19_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_21480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002671">
        <property type="protein sequence ID" value="CCD17320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21480"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389198" evidence="5">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="79"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="44262" checksum="A236573A73B95EE4" modified="2011-10-19" version="1">MMKLFMVCLVVMGGLVREWRVMANTEEHVKEGDNREPYELLCRIYNVAQYPPIKPVDTKEYQKIVDDIDALRAAANGRERVNTQSEETKSAQTQLIGISQDAKKLLNEIKKINPEGEVEKARNAFNTVIFGKNGKDLSPGWLEIDLSRMAACGGKEKKGTSAGKNLIVDFFCLCAKHDEDNEWVDKVCGVSVGSGKDSGWGRNFHPIATMWDEVKNGCGTFAKQGVTSTQDGYSVYHDFLENVKTGGKVKVNSSIIVHKHGMLGTAVSKKGKNDFNCNGKKEVSSGGRSISSASGVCVFYGEQHLEENIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADSQQEEEKTQEPTQAQDPNPDENENADSTTRSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJA3</accession>
    <name>F9WJA3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22280"/>
    <dbReference type="OMA" id="GASEICW"/>
    <dbReference type="OrthoDB" id="1654506at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="821" mass="91938" checksum="7605DA1AF081DC17" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJK3</accession>
    <name>F9WJK3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_23250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002738">
        <property type="protein sequence ID" value="CCD17508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23250"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33673" checksum="F0B479C68CAB249C" modified="2011-10-19" version="1" fragment="single">SLQKAVEVNKKIEEARLSAAQGIFGDDVKDVPREEGKLTGFLGNTESIFVSNVSANESCGNSAGKSVGKSLINDLFCLCVGEGNPDGKSEPPCHMSILPPKKKGNNGVWTQMKCKKDEDKPLNLTESLVKIEKVCRISLRKTKLTKNIPDLLVEFLGMIGKGDEKVKTNKERKIFGQSGRQAGRGQVTECTGTGVTGNSGQPDYHNDKMCVDYKNNLNGENNYDIPWHKKFTEAFGRINEAKALEDVILQNHAEILLLKSKAWIAYSREKEDETTNLDDMNVSHLFDGSRILYTISFSLLFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ6</accession>
    <name>F9WJQ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_23750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002754">
        <property type="protein sequence ID" value="CCD17564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23750"/>
    <dbReference type="OMA" id="TFMLVGR"/>
    <dbReference type="OrthoDB" id="1429985at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="271" mass="28420" checksum="768C056FA2D8E632" modified="2011-10-19" version="1">MSNNAGSALAQQTSLSIESPAERSVVLHQSPSSAAIDLPTNNTLVPTTATTALQDPANNSQGTRVGNTAGQVGRYAATNDFANDYSAGMGYNGLGMSGLGYGGLGMGGMYGGLGMGGMYGGLGMGGMYGGLGMGGMYGGLGMGGMYGMGMSEDFQRSQMTFMLVGRLLEMCGMFAGVIQMTFGSALQFMGSYIGMSQQYNKLQSGMYVDEGGRWVELPKRNDSTEASAGSSANRTISRRSRQTTRSGMLLGVLRRLLFMLIAVSLVRRFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJV7</accession>
    <name>F9WJV7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_24210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002777">
        <property type="protein sequence ID" value="CCD17615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24210"/>
    <dbReference type="OrthoDB" id="1530619at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="303" mass="34284" checksum="95B4238C819CD5E8" modified="2011-10-19" version="1">MLTSLDNTTTDAIQNFHDALQRSQEALRQEEARLAQLSQAAQQQHDANSTRREFIRTQQQPRLDALHREIARVRSLLEQQRCEVRQQQSQLEAIRRPRRDGEAKSSELRRKVEGQQWEYSRRATAVQSVLLQWWCPQNSLENLTAAASRRGAEVEALRRSGAALQAKLEELVAANCQHDSTDDNMSNLAGNGETCDGNENDNTTTAEECCNNGVSAESLQQQLRDHHEEREAFLRSSAEVISTRRRESQRLKVELQRLCTAVEEADAARQESQQRLRAALNERGDACVKCCRCGVDVVGSFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK53</accession>
    <name>F9WK53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 98</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002810">
        <property type="protein sequence ID" value="CCD17714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02770"/>
    <dbReference type="OrthoDB" id="1656596at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="641" mass="72934" checksum="A5ECB0671D8D89A4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK78</accession>
    <name>F9WK78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_25240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002820">
        <property type="protein sequence ID" value="CCD17740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25240"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389245" evidence="5">
        <location>
            <begin position="21"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="343" mass="36884" checksum="6092983482A9BDDA" modified="2011-10-19" version="1">MRLMKFLTVVMLAMVIGVTGIVPSGTATDHNGEKHEALCSILASAVSILNSGRGGSKLQGALRRAIFGSTTGGNIRTLLGGLPSIHYDLGNRKNWCGTCTHSDSDHYPGKSIPHDLLCLCTVGGNGYPFTSDGSIRQLCGKSATDLGCDVGSGSRCHNGNGHGWSDSKQGEQARRHLSATWDSVVNTCLQNGLNLDLDKARQIIGTKLKIEEEHSSPIWARGHSIGSCGGEWGGICVNYDSWCDPQTYPQWLKPLQLALETADFASVEVTPAQATRGTTNGKATQVSRVRRGTDTASQNTHQSETDNQQLHTTDTKPISHILKKEDGTNLTQPFWLLCAIFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3B7</accession>
    <name>F9W3B7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000388">
        <property type="protein sequence ID" value="CCD11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25950"/>
    <dbReference type="OMA" id="KSDRKSM"/>
    <dbReference type="OrthoDB" id="1289514at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="46418" checksum="8B0E5280B1B09E43" modified="2011-10-19" version="1">MNGSAVSSLTNARGMADPMETSRSRMRGGQWSELGSEAGSGLRSSRRYGNRFGSELGESDLRSSNAYEHSRHSSRSSAADYHEEAVPEYQPSAEELERAERAQAIAALEDELKGFTSHEERMEPVLQLYEEVIELRREAEALKEDEDRAVRQLATGDVSSLYDGDVERVVGELEAAVENSYLQACWTKERQRYTAKNGTDLPEWWRVNLADLMPRLQDAKRLFERSNGTARDLYRNHEAKVNANTDARDKVKAEMLVEIAGELDQLKQQRERLLVIDKEQRFHLRRGTHVKELQLTAKKQKDALESRAGHEETRQFGAGVRLNDVIHDLKMQIIQLQRELRDVKVSGETTLRLLQSQMQDVTKSGEEVRKARAEYEEENESLMSLKHELQCVLHYVRVRAREANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M5</accession>
    <name>F9W3M5_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_26960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01000438">
        <property type="protein sequence ID" value="CCD11746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26960"/>
    <dbReference type="OMA" id="IYMGVYV"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD11746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="43919" checksum="CD287142E77C29F9" modified="2011-10-19" version="1">MLVEKPAVLFRARKSRISVYMLPLMTLLALAMVGYTLYGIGNGDHTPEPAYGKGYEDPPQLDAYLRFIPPDVVSTWKAREFLVVMGIPSVDVDGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRRRIGEGGSWGFQSEVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRMYRASLLWTTDDIVFAAGYCTTLSKDAAQAIVSYKPLAALLRKPYSIWHMMQYSSMSVMHEDIMVGRVLREKVKFEDLITVDMRSCKFHESGRRGIFTTVTQKSVVVHHIREEDYQRLWEWFDDNGKSHVPSQLRWFSETSATLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U1</accession>
    <name>F9W3U1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1109</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000473">
        <property type="protein sequence ID" value="CCD11815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27590"/>
    <dbReference type="OrthoDB" id="1727180at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16065" checksum="00ABEDA3BCFC2624" modified="2011-10-19" version="1">MIFRHNNVSLSQSRHELLALENKSSCGIVSASNSCNFVTTFRVILVRCFTYLSRIKGSDRPPVSGSNFFLESLSGNSAANNCGDSNGALSGDAFVHGPISDAQTPASCTIGPIRLEYVALGPSESRTHLLDQGEVTRKFPSFLASSGEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3V2</accession>
    <name>F9W3V2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1114</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000478">
        <property type="protein sequence ID" value="CCD11828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27710"/>
    <dbReference type="OrthoDB" id="1666453at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="543" mass="57706" checksum="8110A43E86129E39" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W431</accession>
    <name>F9W431_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000509">
        <property type="protein sequence ID" value="CCD11914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28500"/>
    <dbReference type="OrthoDB" id="734703at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005184">
        <property type="entry name" value="DUF306_Meta_HslJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03724">
        <property type="entry name" value="META"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="META" evidence="2">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="240" mass="26010" checksum="A52B2A3E08D602F4" modified="2011-10-19" version="1">MMYHTTITPSSCFLSSLRCTAVVFFLLCAMLLVLVGWTLVAMNCLTVLFLFLGRLLSPTMDGAMLCGTYKVINIDGNACSEEAFVAVETTNDGVKVEAMVGNTLCGKGVVDGGRITANLESTMKLVEDRKMRIEDLLICGFRSGFAYEINDMGLTLTGTKGTLILERDVLSDVQFGEYTLCEFNGKPLTSDEMSLVLLPAVIGGALVIAQFKNSFRGELSFGAAGCRVSSPRRCSRWTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W451</accession>
    <name>F9W451_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000514">
        <property type="protein sequence ID" value="CCD11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28720"/>
    <dbReference type="OMA" id="TIPLMGQ"/>
    <dbReference type="OrthoDB" id="733473at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="21828" checksum="352FA4D0C241C593" modified="2011-10-19" version="1">MRFIGTIPYKEQFPLLPGVCTEVSDNVELALRNSWKPCLTVVGDNLPDAVTAGNVNRAMTTLRLSLRVPPIVDAEKATAAMKRILEADPPYNAQVVFTPDPAGSGCATPELKPWLFEALNNGSVTAFGKPFASQGMGGSIPFIAMLLKKFPEAQFVITGVLGPKSNAHGPNEFLHVPFAKSVTTCVARMIADHFHVTPKLGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W462</accession>
    <name>F9W462_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1149</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_28840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000518">
        <property type="protein sequence ID" value="CCD11950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28840"/>
    <dbReference type="OrthoDB" id="1088008at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="551" mass="60401" checksum="03772A84B077CF0F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4C4</accession>
    <name>F9W4C4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trypan_glycop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_29340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000540">
        <property type="protein sequence ID" value="CCD12013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="17"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15735" checksum="D56FA62705835BD4" modified="2011-10-19" version="1">MKLLEWQSKFIQSKSKGSGSEECKITGLLFRQIRKEIEKTRKEVEKFEEEASKAAAFAVNSAGRLDEFITVFANAKGSDSSYFCLGDGSAAKPEDSRDCFSGTDFREESLDDIRESASGQEPNFFSAIKSIKYSKLSSHFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4K1</accession>
    <name>F9W4K1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000566">
        <property type="protein sequence ID" value="CCD12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16230" checksum="C9DCF43CFE6642C5" modified="2011-10-19" version="1">MRYYRQEKRHNGANPSATQATHHARDTNPKVGEEDDHTNKKAAPHSNLLTYSQHAHWKHTFCCCCSSCIYPARAPLDARLLPVLLRPAWGFDCNANTVLASFRKIVKQTACNGKAFFPSLWETTGTANDCAGDGTSSLLGGRTHFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Q3</accession>
    <name>F9W4Q3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_30610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000591">
        <property type="protein sequence ID" value="CCD12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="HTACELI"/>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="5">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="298"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="548"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="834" mass="92560" checksum="4D424E025B3C9586" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4X1</accession>
    <name>F9W4X1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1246</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000625">
        <property type="protein sequence ID" value="CCD12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31220"/>
    <dbReference type="OrthoDB" id="1721106at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18152" checksum="CB1C32C0B3826D15" modified="2011-10-19" version="1">MNWSFPPAFFLFYFFKEERENKGPPLPKTKLENYHLDIQSPSKHCCSFTGKLFSTPPHCTFQALTQDHRRTTLTLFIHNALLVPGPQDAYRDRHPSLTAKQAKHAKRFPDQLEKGSGNDQGDLLRCLSSCCTVLVKYGHEQTIVEEVAKVGDNSPGGFPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z4</accession>
    <name>F9W4Z4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000634">
        <property type="protein sequence ID" value="CCD12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MLISHFE"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17201" checksum="C6129F5203F1BAFF" modified="2011-10-19" version="1">MLISHFESDGPKRVLARCCLYKPLIPNFPLVDGFFVVEGKGPKTIVLLQVTKAQEHHTKKTTVHEFRNYMGKVFEDWERIEKDYSLEIIYIQHVDSTAIKKRLRCASSRYAANDTDLALWDRIHQYQVTLNSDIANEFISRSSDPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W573</accession>
    <name>F9W573_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000668">
        <property type="protein sequence ID" value="CCD12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14249" checksum="8037D0F9EF326020" modified="2011-10-19" version="1">MALAPISTARLFPSLRGGLAKITISSPGPCRVQVSVFLESKSRTPLRQGRLSVVRAGPQRNKNCSKSVKLTNGIFRLRLLISLKLALKSRSILSGLLRGLDARFPRYFVSMLFSLNSYSVTQLAQAISET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Y5</accession>
    <name>F9W5Y5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1402</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000799">
        <property type="protein sequence ID" value="CCD12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34540"/>
    <dbReference type="OrthoDB" id="947320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019497">
        <property type="entry name" value="Sorting_nexin_WASP-bd-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10456">
        <property type="entry name" value="BAR_3_WASP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="SSF64268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="303" mass="34752" checksum="2D72C08EDE92D2EA" modified="2011-10-19" version="1" fragment="single">MAENAFEFRVLEPEERRGGGTLELTYWTYRIRTSTTLPMYPRKEMEVVRRYNDFVWFRTQLAEAYPYCILPPIPEKEVHGTLDKLIGSTSQNATRTRDYRQRALRKFLIRIGAHPRLHTSQFLQDFLEMDESEWERRMQAPVNTPARSLKDTIGGSVGNVLSRPWKENQTLEEAGAAYAQAVGNGTTDPSAWEGTRKYVKQLDESLMALRERVQILVERRRNTSNSLHEFGVAFEKVSEVDGMAGQSPLTRALAAMGQHNDQLSTLYVEHASDEMKQIVETLTYYHGMCKSVCATLKHVQNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W644</accession>
    <name>F9W644_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1422</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_35080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000821">
        <property type="protein sequence ID" value="CCD12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35080"/>
    <dbReference type="OMA" id="KTGNTHP"/>
    <dbReference type="OrthoDB" id="1295576at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="SSF81383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="706" mass="78059" checksum="09BAE192280D90E8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6M8</accession>
    <name>F9W6M8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_36760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36760"/>
    <dbReference type="OrthoDB" id="1675706at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389864" evidence="5">
        <location>
            <begin position="28"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="362" mass="39449" checksum="74A0664612ABC655" modified="2011-10-19" version="1">MKVLSWLRVSNLVVGLLWVQVVLGAQAQDSKNGFQVLCDVLRHAERVLNSADRNRVALKEALFGRNNGVLAVEKGQVSVKGACNYQTKRELLCTYYTGGKHGCFAQTLAGAILCTCTPDQRGGNFCRFGALNSGGTWSSGWLENQKDLFQKVWDQVKEKCSSEIGSDPTHTEPLDDLKDALDKVRGNLSQADRNSFYLGEPNCARKYGSKSCVTYLGKDRHHVHIPWLDTTQKALEDLKQASPREAILVQTTAPTTGTSPAPKESAPKNPEHSEPSSTPNTTTEREHTEDTFPPGTPSPPENQPSPKSRTRRSTTEDPTAISTAPDDSVILDPTVAPFSSPEGDSTDILTPLGLFMAASSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U2</accession>
    <name>F9W6U2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1526</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000936">
        <property type="protein sequence ID" value="CCD12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37370"/>
    <dbReference type="OMA" id="QCDENDL"/>
    <dbReference type="OrthoDB" id="824020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-oxidase_C" evidence="1">
        <location>
            <begin position="22"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="328" mass="37525" checksum="46984EA177E395B3" modified="2011-10-19" version="1">MFIGSEGAFGIVTEAVVKIERIPEVKHYEGWFFPSFEIAFAAFHACTRKGIHPCTMRLYDEDDTRLSFAASTDTGTLSTLFSKCFKRYLSSLKGWDLSTLSLSVVGFEGTKAQTNCQRKELSGVFKSFGGICVGEKPGNTWQEKKYDLPYLRDFALSHNFWADVFETSVFYQDAIRCWRAVKKSFADIVRENGKTAWIGCHTAHQYRFGCCLYFTFIGEQCDENDLKIFLQIKQKAMEAMLQHKATLTHHHGIGYEHVPWMRRYHGEVGLDVIMRFKKVVDPKNICNTGKLLPSLPGEHEKAKAVEVRQRREMMFDKMGIPGAIRAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U3</accession>
    <name>F9W6U3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000937">
        <property type="protein sequence ID" value="CCD12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37380"/>
    <dbReference type="OrthoDB" id="1741943at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13387" checksum="2415CE622EB12797" modified="2011-10-19" version="1" fragment="single">MDCNNDNDTLTVQNFFKCAMRTLQVTDERRRNCEPKPSLDEAGSKIDTCCGVISEEERCGWKETAALFHSIVTNDTLQMPTYEDGSMHCLIVRLCDGLLNYISEYQASHDTARSSAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W718</accession>
    <name>F9W718_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000964">
        <property type="protein sequence ID" value="CCD12976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1655444at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="890" mass="93593" checksum="ED16D30D48BE2DBD" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7C9</accession>
    <name>F9W7C9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04210"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20149" checksum="FFBB00564EBAFBBA" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPFIHSYISRFSITDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7D5</accession>
    <name>F9W7D5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001009">
        <property type="protein sequence ID" value="CCD13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38860"/>
    <dbReference type="OrthoDB" id="1716553at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18281" checksum="964B69A269F78374" modified="2011-10-19" version="1">MHRGCSLGIHSHVKLLCLCTRNLAGIGHLSVVPGFSALSRPPHGLGQSQQTDAGQTHSESIAAFPTVWSEVNEHGQALSCVCGHGNSLLCRLLLFLSGDAEYNPGSMKLLIPSGCYQPGRLQQHRVAACLSDTGNPFWKEVVEMRSLQFYLLFNILAWWFELHVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7J2</accession>
    <name>F9W7J2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_39380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001042">
        <property type="protein sequence ID" value="CCD13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39380"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0675">Receptor</keyword>
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            <end position="55"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21102" checksum="348523AD90A71934" modified="2011-10-19" version="1">MAARAESVANGGQVLLTGATYYSLSAVERARLDLMPMGPVLLRGVPEPVEMYQLNAVPGRIFAALRLDREVDLINDESDATGSSPSDSSSSTATLCETSQMVARCLESVLGTFAPARRRSLLVAICERWRVSLPRKPEAGWDEDYCQNVIRRIALRVGHAMDLYAADRDHSTGRASSASVILMPCRRADTPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
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    <name>F9W7J6_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 162</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001044">
        <property type="protein sequence ID" value="CCD13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04290"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24303" checksum="6CA457C3245692B2" modified="2011-10-19" version="1">MEPGDNIKDSANSGCSTATCEAGHPSKNKKNRRGQRRTASDVAACKALPQQAPDSLLTASCASGKTEIASQAKPIVNSTSVRRRAKPTNTITRVVTSVSLETLRAKRNGTNPEDTDSGDKTVQEVSRILLMYSSWQQQHQQGIKGISSRQHMLVPNVANVATTYGGGYNVDPMEDSLPKVTVGFVGDQQSHGFQQRQFNLGDFGTSDPREHVTLLITAGKLPPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K9</accession>
    <name>F9W7K9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1625</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001048">
        <property type="protein sequence ID" value="CCD13177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39510"/>
    <dbReference type="OrthoDB" id="1655084at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="828" mass="91084" checksum="26138CA5B9E31178" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7M5</accession>
    <name>F9W7M5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1630</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001053">
        <property type="protein sequence ID" value="CCD13196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39670"/>
    <dbReference type="OrthoDB" id="1715963at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="16678" checksum="E842343ACFBE3E1F" modified="2011-10-19" version="1">MKTHQPSGLHSALKRFPGGQCFSEVTSSREPITLLPKTCVLLTALPDDPKLNGFDGAAGLSVEPVTALPDDPKLNGFDGAAGLSVEPVTALPDDPKLNGFDGAAGLSVEPVTALPDDPKLNGFDGAAGLSVVPVTALPDDPKLNGFDGAAGLSVVPSQPSPMTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7R1</accession>
    <name>F9W7R1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1643</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001068">
        <property type="protein sequence ID" value="CCD13233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40020"/>
    <dbReference type="OrthoDB" id="1768432at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19098" checksum="70676E051A448AFC" modified="2011-10-19" version="1">MIIYIYICVYIIRMCVCVMRGCCCCVLVCVRCPSFVRIIPIRIRPGVVCGVCWGNRTWWGAAVVPAAISKTRLGARTCPNTRPPCRSLSLVLRGCLRLCARPARARRRWRGGDDVFLCRPTLIVCALARFSPSSSPPRPHLFRAFPRVLGEWRRKCVCLEEEGAVGEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S1</accession>
    <name>F9W7S1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1647</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001072">
        <property type="protein sequence ID" value="CCD13243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40120"/>
    <dbReference type="OrthoDB" id="38414at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039586">
        <property type="entry name" value="CFAP46"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15977">
        <property type="entry name" value="PTHR15977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1752"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1752" mass="195494" checksum="BAABB5D5B9AF4787" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V4</accession>
    <name>F9W7V4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001085">
        <property type="protein sequence ID" value="CCD13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40450"/>
    <dbReference type="OrthoDB" id="446795at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="666" mass="73117" checksum="04ED0881A13BA266" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8W5</accession>
    <name>F9W8W5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1790</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001230">
        <property type="protein sequence ID" value="CCD13651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43890"/>
    <dbReference type="OMA" id="DISKECI"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23912" checksum="549B793FD3120BA7" modified="2011-10-19" version="1">MGVLHVSEGEQPHLWSEAQAKVVPDPWDSWEGDEVPGVSGKLAMAVLSSQKGWPYMLFDADEVQKRRVDSLTEYNAVCDAYIRRENLRAWHIVQENINRWSSGVEDVHPFIVIGTPGFGKSSAMGSLLLYQLLHYTLEDLKVVAYFVRGEAYIFHRNERRVVHYDKKDDAVVKIKCRARRGIEGHIIYDISKECIGVSDLIGRWGIVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Y1</accession>
    <name>F9W8Y1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1798</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001239">
        <property type="protein sequence ID" value="CCD13667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44030"/>
    <dbReference type="OrthoDB" id="1230974at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37497" checksum="BEAEF72ABCA7E6CB" modified="2011-10-19" version="1">MSSVNAIQRLSREKKELDKSRVREFYAAPIPDNIFEWHFTLLGPAHTPYADGLYHGILRFPREYPFKPPDITFLTPNGRFQVGKSICSSISSYHPELWCPSYNVTLILVALRVFMGQDDELGVGALARQYISADEKQRLARESRRFSCPACGMRHAEDIWQEEMERHPPVGAEVEAKVPKLPPSNTPVAEEGSELTPDAITDSTREDGGVIADEEGAVEADGVVDDKITKEEANLDEMRELNAAASQPLAEDAIATRAVETEAEAQEGGTGEKIEPLVAEVNGESKLAEENGEVAALQPGVLIGFGDFVEVHVPFYILDATIRISLFLCIAVIAKKALWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W955</accession>
    <name>F9W955_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proline dehydrogenase</fullName>
            <ecNumber evidence="2">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_44530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001263">
        <property type="protein sequence ID" value="CCD13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44530"/>
    <dbReference type="OrthoDB" id="948528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006562">
        <property type="term" value="P:proline catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390025" description="Proline dehydrogenase" evidence="3">
        <location>
            <begin position="30"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="436" mass="49504" checksum="F49568CCA96B5E13" modified="2011-10-19" version="1" fragment="single">MMWYSALLSSHCLLVVFTKVLLQIRPTEMFRIVFRHLQVAGTKGAHLRTLQKVDFSDPTIFRQKSIWWLLRALFVLRMCSIEFISNNSVALMKRAESVLGPFLTYNTIVKKTVYGHFCAGEADRELRNTIKSLEGLGIGSVLDYAAEADAEGFAPAPGMAEAPNLSMASLVNNTSVTYLPHKQAYDENMKLYVMCVLHSALHKPKGGVGLAAVKVTGMCDPQLLARVSAILHMVHRDWIEYFTEEQPPPVEECNVVMGTKTEHKRYITRDQVRKGLTNLAASRKYTEDEIKAVLDVLDPDNEGRTNYYKFKTVVSEAVLPLDLTQGQKIIFAKLPNLPPKERELCRHCHWRWSVIVEPPKDWGERVLLEPDQPFSHLAMAILFRKFRARFTGRGPPVYTRSQCSWTHTEDGVFKDLRRADLEGWFGGGKVVRGAYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W986</accession>
    <name>F9W986_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_44780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001280">
        <property type="protein sequence ID" value="CCD13777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44780"/>
    <dbReference type="OrthoDB" id="1678286at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389987" evidence="5">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="37774" checksum="1F11D6D6292FB773" modified="2011-10-19" version="1">MMTMMVWMVMIVFFGVVAGEEKKNYNEAEHKALCDLLRVAVDKWGEVEKRVPTDPLRKALETTLFGYGTVGTLETLKSGLPSDYNDVEGTDSPRSNWCGQPLSGQYQDSYPRWPGYSAPHDVVCLCTAGSHGWPINKTGKLCAQDKDTLKTDSEWWSGTNNTHKKDAIGNTWEVTVKRCLSGSSQEKDLKKALKKFTDEIKHKIEGGENFYVLGENGSDYIESPCNGSPRNGLCVMYHPNDTDTKTWWKDLDEALEKDEQIQKQREEKERRRQKENAEKKDSAQKEAPSAHITTNQTDQQHTGSTPTDKLRRLNPTSGTPISRPSSWLLSAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9J0</accession>
    <name>F9W9J0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001319">
        <property type="protein sequence ID" value="CCD13892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="102" mass="11621" checksum="C2485AB9A4E874F5" modified="2011-10-19" version="1">MGWERKIIVTCWIVGNVPPKILYQFTCDTRKCNGGGAYAKENFTSLKVVCGLKDFCRESIRSFGSCVRCFVERSRSHTIVSQCNAWRSFVMARTRGDSALRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T8</accession>
    <name>F9W9T8_TRYCI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001349">
        <property type="protein sequence ID" value="CCD13993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15942" checksum="7A44CEA6BA9A668D" modified="2011-10-19" version="1">MLTFLCFPHFPLVLFLVFNVFFLLLARCPLLSVSRWPFDMLYRTSHGHDAKCFGRKQSATFLHFCAFSFSHQVVLSPRCQDFVVFKRSCGRPVVLLLDEFSMIMRAWRLPLPVRRNAHEMAAILRCGILRGECRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA08</accession>
    <name>F9WA08_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1915</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001370">
        <property type="protein sequence ID" value="CCD14063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47310"/>
    <dbReference type="OMA" id="CAIGDQA"/>
    <dbReference type="OrthoDB" id="342376at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="470"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="545"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="854" mass="99395" checksum="302BCE6C272BA3F0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAU0</accession>
    <name>F9WAU0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00650"/>
    <dbReference type="OMA" id="TICQMLT"/>
    <dbReference type="OrthoDB" id="197637at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1473" mass="165201" checksum="DD0F8CEBCE7D1E68" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV2</accession>
    <name>F9WAV2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_49930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001486">
        <property type="protein sequence ID" value="CCD14374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49930"/>
    <dbReference type="OMA" id="LPNCLYT"/>
    <dbReference type="OrthoDB" id="1550429at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="314" mass="35447" checksum="45E50AA39966264B" modified="2011-10-19" version="1">MCRCGRYGPYIFFLVQSLFMIGLVLFVFFPPKAVEEPMCNCNYGVVHKEIPQCQCVCFGDYLLPNCLYTAVDVVEMELWLVSKVDNGQQETHQLLGKDIEAGIDRLFGNNKDSGLFRFRRALTSGITTYDANNTFRQPVYVSALFTMPGWAAQHLLAYVKLNDGRGGGIRNSLSGTEYDLYAVYDASNGPPLPVKYYSESMALFTHIDSNVFIRAADWGWMFGALVLLLLLTRIEELWMYSIITDLGRKSSAPLRVVANPFVRNDDRNKESAASREETSNDFLLARNFGIRPPANTVSSPQVDANDQRRKGYPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB04</accession>
    <name>F9WB04_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2042</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001511">
        <property type="protein sequence ID" value="CCD14431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50460"/>
    <dbReference type="OMA" id="MKPYVWP"/>
    <dbReference type="OrthoDB" id="840565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="318" mass="35285" checksum="6C29E7DCE7F8998F" modified="2011-10-19" version="1">MPPRIYPLECGVAPDTSARAVFERTRRLHAGTLNIFAESNDCSGLSEKQQTRVSREPSGFNGNHSQRGACSSDSKEFGWPHLRRVRLPRKQVAPQGIHQVPSAAAKAQNIQVVGVTDDYKDPSTMKPRRAGVRCFSRNNSSSMSEIMHHDSGEAPSPRPYSVDSSAPGSRCGSRCSSVGRRRLVEYTPLERFSQAVRDHVQRRRGGITEFYVNLARGRVGTVVFSTPASTPRPWKLEEGPVTHTLTLGSCLDQLQSLTGMSVTMNELAEMVWGKEKVGEMKEECNDEEELAGYRVTYRDFSVAFGDSPLDGKFETFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB31</accession>
    <name>F9WB31_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2052</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_50720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001522">
        <property type="protein sequence ID" value="CCD14462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50720"/>
    <dbReference type="OrthoDB" id="1579101at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="SSF47676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="3">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="174"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="33581" checksum="6C40D3F199F34574" modified="2011-10-19" version="1" fragment="single">MTLQRRLDPGDRVWIKLDANSWWPAKVIHVEDEETRSGAVTGGVVTVSFYGDNDAPTTTTRYSLHSGSIAYFETSSQKAVTSNQKLLAAIRSAEEDEDANALRFDYSLKAAEGESTSKVGDAVVSTALAAKASIAALNKGAAGSQRATVTKRQRDASGWSQVDNLFEGGQLSTDRLVEVANIINRAVEENDAPSLRSTLFELDNVVVSLQQLKLTKVGVAVGNILGKNELQELWPISRAIISSWARALPRKPKQPFKPFNRIEKKGARMVKTPTHKQMGVSAMENMPGITTTGPPTTSQGNRRGTGNITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB73</accession>
    <name>F9WB73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2070</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001541">
        <property type="protein sequence ID" value="CCD14504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51130"/>
    <dbReference type="OrthoDB" id="141294at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="PTHR12189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="623" mass="69609" checksum="57BBF92929109FB5" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBD8</accession>
    <name>F9WBD8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001566">
        <property type="protein sequence ID" value="CCD14570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51740"/>
    <dbReference type="OrthoDB" id="1711718at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19064" checksum="8B4FBE971803E200" modified="2011-10-19" version="1">MHSLKDHCSFGAAKRYFSRETAVDYRRPLESELPIPRELYHRVRHGHPEVLRYSQPSAPPTLLCNRQAATKPTPVAVAKGRMVACKRDGGRAYVKLIPEAPSHTRRCPVRLRSVRWDAPTVMPQRLTHGEKATNKSSGAVEAHGTVHCRRRGVINLGRVGTEGTTKPCSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBI9</accession>
    <name>F9WBI9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2111</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001586">
        <property type="protein sequence ID" value="CCD14622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52260"/>
    <dbReference type="OrthoDB" id="24674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="654" mass="74506" checksum="FACCA82D11B8DF4D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBL0</accession>
    <name>F9WBL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001593">
        <property type="protein sequence ID" value="CCD14643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388944" evidence="1">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16201" checksum="E57D248E36BD18A2" modified="2011-10-19" version="1">MGLSFTSRNNPSALFFLILCMLTCLDSRKFKIPMLVFISSPSVSLPSPFPCTGMVGNHHDKLMYICMYALLVRCAQRFQSVYAYDERRPTDPFHPSMGLFLHTIGCTSWHLKVSIIPLLPPRLPLLFISNVLDSKRRHLKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC05</accession>
    <name>F9WC05_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2168</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_53780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001650">
        <property type="protein sequence ID" value="CCD14792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53780"/>
    <dbReference type="OMA" id="YYWANIT"/>
    <dbReference type="OrthoDB" id="49756at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="PTHR11359"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="941"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="961" mass="111534" checksum="587E12F4E80A73FD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC33</accession>
    <name>F9WC33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001662">
        <property type="protein sequence ID" value="CCD14821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="15411" checksum="82719F9E3427AF4D" modified="2011-10-19" version="1">MRGSEDALESLKCATKLAKDALKKGNVSGKSTFYFGERNESSSCDGMNGNNVCAAHQGEPKANVNVPWIVRLNQAVDELGSVLSPTPKESKDSAKIPQKRTESLLLIPGESKETAPHVEVPPRESNEISGKKEHQVGIAPKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC92</accession>
    <name>F9WC92_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001686">
        <property type="protein sequence ID" value="CCD14885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15822" checksum="22F116C39F64F231" modified="2011-10-19" version="1">MKAKEGEREAKKEMYMKIYFAPRSTTLSASILFLTYYFPRQWWASLPSVFEVIQQGSTRQIGNRRHTHQVLTAPVSMNHLSPESVAYLLTGRGDAKSKEGKNNNNNKETLLIGRHSFLYLPPLSAINEPRQTRYILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD0</accession>
    <name>F9WCD0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15457" checksum="A490E11A00CF5C8E" modified="2011-10-19" version="1">MSVSYFYGPLDQPTDARVDGDRHTKVRPACKASWKARHHSRTIGRSPGTVQNRRTATQPLDNGARRHKKKEKASIKQAKERGYISRPKRGEITPAHFHRRVEQQKAPTRPVTSLKPLHRHKEGTRPPLSMGGVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD1</accession>
    <name>F9WCD1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_54930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54930"/>
    <dbReference type="OMA" id="WICFTIS"/>
    <dbReference type="OrthoDB" id="704215at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="SSF101601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="394"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="900" mass="101333" checksum="7E0793332FB7A882" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD2</accession>
    <name>F9WCD2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2213</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_54940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001700">
        <property type="protein sequence ID" value="CCD14925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="NAPIMIS"/>
    <dbReference type="OrthoDB" id="704215at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="SSF101601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="2">
        <location>
            <begin position="178"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48841" checksum="C9E58C07F5F7BFCB" modified="2011-10-19" version="1">MLLDSGSMSGTFVDEFDEGVVTKHGQSSIYRFGRPLYKGTPTACFDGGLLFRIVEENNKNRWSFYNDVPNSEMNVEVIFGPNSDIKALGNTDMTKLSDGSIKCTVVVYPLETELFIEGVCNGYKSNIVAKELTNEYLEDVAVQNTSVIKGEISVMEKLAARDASPDDALAACIAKKTKFLDLTFPPTQESLQTGTVTRMKVIPWERPSMFLSDENALQARLFRNDINPNNIDEGELGDSWFTGALACVAEFPNRIRDMFRHPRSLDEGKNERAIGAYRVTFNKGGWWVNVVVDDYLPCSGGQPIFARSYGDPLELWVSLAQKAYAKLYGGYGFLVVGDPLHALQDITGYPCSSFNTAFETAKLNGGEELFGHLLHYSQAHHHTILVTPTRNALQLQGSTGEAYERLGLLPGHVYKVLKVLSFAESGVFLLLLRNPWSAVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ6</accession>
    <name>F9WCJ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2240</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_55570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001731">
        <property type="protein sequence ID" value="CCD14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55570"/>
    <dbReference type="OMA" id="VYNKVNE"/>
    <dbReference type="OrthoDB" id="1506658at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="PTHR13000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nup54" evidence="3">
        <location>
            <begin position="212"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="424" mass="43971" checksum="6BE31DC696369C92" modified="2011-10-19" version="1">MMGTLGGGTAGAAPAGFGTANTSTATSGFGAPAGKATTGGFGAGATTGGFGTGATTGGFGTGATTGGFGTGATTGGFGTGATTGGFGTGATTGGFGTGATTGGFGTGATTGGFGTGATTGGFGTGATTGGFGGGATGVSGRTTVMGAAQQSAVACQSALARYLLEFDNAYNAMHPNCRFRAFLYNLCTPGQSMMAVERERLIYTAAGGDSREEDLLRAQQRNPDPVRMYPTRVHFMQELKARMDKQKEMLAAMLKHVDSLISKAEYFRELDEENGAQFSELVQEQAMLQRRWYTLLRKVETLRQLGVPLAEESRIGGITNALSAQLAAPDMYRSALKELQPFLDAESAMVTSLVRRHSAVATDGKERGTAANSGALLNNRVDRTLMRDWVRYAERIQQGVESLSALLERDTRDMRAIHRHLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCL6</accession>
    <name>F9WCL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001737">
        <property type="protein sequence ID" value="CCD15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13784" checksum="F2AFD6F703C066A8" modified="2011-10-19" version="1">MHPLISWNRFAFHSLSHVERIQLRTMLKIKTPSFGTWERRFGVWHLLLTLRLPVSPNQITGAKPRSPCISTLTPNSEEVTSPKKKKYHATALRLLPHPSPVGKKTLWINSINILQKVFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS4</accession>
    <name>F9WCS4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2260</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001753">
        <property type="protein sequence ID" value="CCD15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56360"/>
    <dbReference type="OrthoDB" id="1706691at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20223" checksum="9235180F1A4707F9" modified="2011-10-19" version="1">MYSHLPSHTGPHSLSRGAQRGILKNGPPQSGSDRLPSPPLVESEFSVFANPETRIALGKNATSLSPLFDTCWTVPIVHIPEWTLSARPARRGIRVGEPAAPETFQPVDVSVSSSGAYVLTAFPVLLPSVFPYHTQHAPGFLPFVKSQESPRTAPCAMDTASASSRGTLQRLHSKASPPSLPLRFVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCT5</accession>
    <name>F9WCT5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2264</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001758">
        <property type="protein sequence ID" value="CCD15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56460"/>
    <dbReference type="OrthoDB" id="1705855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="201" mass="23589" checksum="2E7F0C9E42A37B03" modified="2011-10-19" version="1" fragment="single">MRWSAVCYLVTNAVVARQSFNEYACLAARSFVSQRQFRHYRPRYFVFAVGRMHQNMLFQPQRIRVLTLRYHSFTSKQEKVNPFHIATAVKKNVQHCGDTQRLWNATSYNIMPKWVAQDSIHNERSCTPRCVSKAALDRTRCEFCIGEQPRLISLLHITPIVRLRVEVNNKRGTKKPYITFFANNNNNDSKENKKNDRXGXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCY9</accession>
    <name>F9WCY9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2294</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001791">
        <property type="protein sequence ID" value="CCD15137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56970"/>
    <dbReference type="OMA" id="ATEEPTH"/>
    <dbReference type="OrthoDB" id="1662946at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="698" mass="72775" checksum="24298B5A188D0815" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD13</accession>
    <name>F9WD13_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001799">
        <property type="protein sequence ID" value="CCD15161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05860"/>
    <dbReference type="OrthoDB" id="1666333at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390165" evidence="5">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="80"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="401" mass="44245" checksum="D12A9EA894ED3247" modified="2011-10-19" version="1">MMKLFMVMVIMVVMGGLVREWRVMANDKVSVVQGDNSEYFNLLCRIYNVAQYPPIKPVDTKEYQKIVDDIDALSAAANGKERVNTQTEETKSAQTQLIGVTREAHKLLDGIKKVNPEGQAESARHAFNQVIFGKNGKEGDLSKGALEVVDSRMTACGSRPLEQKGESAGKNLVVDFFCLCAQYNVFNEGVDNVCGVSVGSGDGTGWGAKLDSIATMWNEVKNGCDKFVKQGVTSTQDGYSLYHELLQKVKAGGKVKVTNTETVPKHGMLGTAVSDTDNSNFHCNGKKAVSTTRVKVGSGVCVFYGTHHQEQNIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKAESQLEEENTEDSPLTQHPNPDENENADSATQSQRHSHLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD30</accession>
    <name>F9WD30_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2313</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_57270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001812">
        <property type="protein sequence ID" value="CCD15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57270"/>
    <dbReference type="OrthoDB" id="1524649at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394685" evidence="1">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="54"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="229" mass="25054" checksum="80A01469C1585DF9" modified="2011-10-19" version="1" fragment="single">MRALLAGFVLGIGAHACVCGGHSYGSSIYVSPLPQNLNNSLVFVDIVRCRAGVLTAHRSAAGRVTIELFDDASPVSTTNFRELCRGRHGKSGTGHDLCYRGTRLFPDKHCITGGDVTFGLVPGGWSIYGKQYRETPRKNNAKGAGLLYAIGEHSHLGSEFVIGMEGFTPDREHVLLGQVLEGYGALQKVQQQCSRPCATHFISYHISDAGVLREAKTPNYRRGWRFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA5</accession>
    <name>F9WDA5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001844">
        <property type="protein sequence ID" value="CCD15257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05980"/>
    <dbReference type="OrthoDB" id="385042at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22139" checksum="1863CE3198348B6F" modified="2011-10-19" version="1">MASFRPVTLTSTLCKLMKRIVARRVRDCVEDKLQPQQSGFRPARSTLDTLMQVTSAVRRRMDGEKTAAMFIGYARAFDSVDHDCIVKVPLSFGVEMHLVAWIADFLQGRTAQVRVNNTLSEDISLTCGVPQGSVLGPLLFIVTVDSLSKRLNCIPRLQHGFFADDLTIVCTSVDLSAIQQSIQQGLDCITRWSEEHYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDV9</accession>
    <name>F9WDV9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_59840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001917">
        <property type="protein sequence ID" value="CCD15464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59840"/>
    <dbReference type="OrthoDB" id="1676709at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390196" evidence="5">
        <location>
            <begin position="21"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="37929" checksum="1181EF9B9DBE2E1A" modified="2011-10-19" version="1">MKMMFKCLIVVVMSVVVVGAQEEEKKDHNGPQHKALCDLMKAAVGKWGRSGEGLSEPLKKALGRTIFGKHDGGDLADLKGLPTDYNNVEGTLSSRGTWCGNPYEAPEFINAPTRWSGHSGPHGLLCLCTVGEKGWPLNESKNGIDKLCGLGKNALAAEDNEGWGYTGHQGNKHVTAAWAKIVTPCLQSSGMEDLKQALKTFLGKLVNKSNKEYTNRYQLGEGEPSEYDGCTGSEKKGVCVLYYNTTGIQKPMPWWVDLQNALPEEEKFQEEKRRAEEEKRKQQETEKRIDESQTAALTSTHTTTNQTDQSHKANLTDTIRKYNISSGTPISRPTSWLLSAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDW3</accession>
    <name>F9WDW3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 241</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001921">
        <property type="protein sequence ID" value="CCD15468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06140"/>
    <dbReference type="OrthoDB" id="1124194at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394700" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="18990" checksum="DE24D7FDA718FF97" modified="2011-10-19" version="1">MELVSALGLFGASPVSAALASVLPPFRESLASNLLQLVRALRATPEDDNIRRVRCGNLRVMAEYGHAGFCSACPTCQSVVSAAEVLWYMLGYRVEYTSVPAANLPAVVQGNPDLCLPCKRLALNHTFVPVGFEDYSERLFTLREPDPSEAPGEWMGWYSRLEDIMHGLEMIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE85</accession>
    <name>F9WE85_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 2447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_60770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001961">
        <property type="protein sequence ID" value="CCD15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60770"/>
    <dbReference type="OMA" id="CHESTIS"/>
    <dbReference type="OrthoDB" id="1703971at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394932" evidence="3">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="254" mass="28287" checksum="3AE029FCD08E4855" modified="2011-10-19" version="1">MASRSAPVVLVVGAVLLLVNTVQSEKEMEKENEKEKEKGMKKEKTPARSSEGTASERRGSVVFTSDAVYYLIVAPQRFLDGVRAAVGKDLEDFLCPAKQLEQLTTPGGLPPSCNITIVRTRPGFLNSTYLLGVQFSRSLDSDVRLMTPLDSGRRNRPLRNETFKRLWKELKAVSGRRDIVPVFQSIIFFNKPLDKISLKEVGNPCSRGWMCHRDTKIIIAIFSLSSALGLIAVFAGFRDSVSPLQKEDTQSYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE90</accession>
    <name>F9WE90_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 2448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_60810</name>
        <name evidence="5" type="ORF">TCIL3000_0_60820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="F9WE90"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60810"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60820"/>
    <dbReference type="OMA" id="SGIRAHH"/>
    <dbReference type="OrthoDB" id="1727325at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031987">
        <property type="entry name" value="GARP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16731">
        <property type="entry name" value="GARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007659412" evidence="2">
        <location>
            <begin position="27"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GARP" evidence="3">
        <location>
            <begin position="42"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="26540" checksum="2A2AFAC17350418D" modified="2011-10-19" version="1">MTTTMSRVLHLMTVTLLCARVGMGQASDDDDCGGQSIPQKVEEVQTMCDVARQLRALETASQSAVAAVVSSAREASEAKERAEKAVERAKSKKRGVDAATEAAARAAAAAQRAETVVSDARKHAADLTAASKDAIETTDESLRLLATCEKADEPIRTAAKKCTGAAAEVTSKSLESAFDALAELLPDGADDIREHGAVFVKGLKSLEDDVRTAGEAKSEAEKAEGDANDAADGARAVLTGVCVLLLLAALHFSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI3</accession>
    <name>F9WEI3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_07070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002015">
        <property type="protein sequence ID" value="CCD15693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07070"/>
    <dbReference type="OMA" id="IENTRWT"/>
    <dbReference type="OrthoDB" id="1404630at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008377">
        <property type="entry name" value="Sialidase_trypan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="PTHR10628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13859">
        <property type="entry name" value="BNR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01803">
        <property type="entry name" value="TCSIALIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="SSF50939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="654" mass="71457" checksum="DD06CF6489312B15" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM5</accession>
    <name>F9WEM5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 289</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002036">
        <property type="protein sequence ID" value="CCD15736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07480"/>
    <dbReference type="OrthoDB" id="1715012at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16660" checksum="A0E2B6FCD237601B" modified="2011-10-19" version="1">MQPGQQIICANAGNNETHFQCISQYPNTHAPCRGQKPQCGQQLLHAFGLHHVPRVPGCAWCRAMVVTPACGNTRGNCTSAFYFIPSSCSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCSTVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEQ5</accession>
    <name>F9WEQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002051">
        <property type="protein sequence ID" value="CCD15771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="915258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="15145" checksum="B93D78AB11B0E73A" modified="2011-10-19" version="1">MVFVLLACSDICGKKVNVTLPFENPPKSLEELYRVVEQVFRGEEKEMKQSTEGGNYDSRPSEPFTCRRIQRYDDDKRAWVEITNEKQLCACDQLYVFRKNATKADISQERELPEPRNTAHFYPCDTKSGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WES5</accession>
    <name>F9WES5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 309</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002058">
        <property type="protein sequence ID" value="CCD15791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08020"/>
    <dbReference type="OMA" id="YEWLMEA"/>
    <dbReference type="OrthoDB" id="150361at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2546" mass="283289" checksum="5F95E9D4D3B01A6E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEU6</accession>
    <name>F9WEU6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 314</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002064">
        <property type="protein sequence ID" value="CCD15812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08130"/>
    <dbReference type="OMA" id="PHRYADV"/>
    <dbReference type="OrthoDB" id="472767at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38625" checksum="871392AC0169CB9B" modified="2011-10-19" version="1">MERVWVHVSRAPLFSFTVGRRTTVSSIHLRCAVEGRDNKVEIECSRFYLWAKYMPGTTTADGVLSDQPPHVVASFQLDETGLASSAGLTWMLAEGSAVAMQLMSQPHVPGILQQSAEELMTSLEDHNNAIASSDVTPEANSSPSCGPLNDITITLVGVEKERDEYISPWRPLLVYRWFELKQHVREATQIGSRSRGSMRPGSEVKFRKRPMLNGEVREATGLSSCGNYVLWQDGTLGYRRELVPYRRFFIPAREDKCVRVRSFPHRFADIVGEVPHGCVVEAIGRKKDPYTKEEYALLVLSGLPNAVALAETYELTSIERGKWVWGWSKIASSNGVVFLWEYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF12</accession>
    <name>F9WF12_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08720"/>
    <dbReference type="OMA" id="ICGACIM"/>
    <dbReference type="OrthoDB" id="229625at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="964"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1671" mass="174873" checksum="647F77D5DF725498" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF19</accession>
    <name>F9WF19_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_08790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002090">
        <property type="protein sequence ID" value="CCD15885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08790"/>
    <dbReference type="OMA" id="RHGKRWM"/>
    <dbReference type="OrthoDB" id="646662at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:cellular aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="PTHR43570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="15"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" evidence="3 4">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="539" mass="59554" checksum="DFC7AADE42E88F1D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFJ6</accession>
    <name>F9WFJ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="CCD16071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10340"/>
    <dbReference type="OrthoDB" id="1715959at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18421" checksum="C58A13AF743797C1" modified="2011-10-19" version="1">MVGVITHLQILWNTLRAEKGTLSLKPSPTRFTRLKKRIKSSRTGTIPYLPPLFSNPLDLPFFCLYGRRKRKKKAQYLEITIMMIHPSPSLAPPWRKRAMEGKDLFSSMSDGKDESSIGSDTIFGGSLHQYADFFSLSIKFGVLWLGRFSGICISISGTPPPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN4</accession>
    <name>F9WFN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 409</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002169">
        <property type="protein sequence ID" value="CCD16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10680"/>
    <dbReference type="OrthoDB" id="1721656at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19167" checksum="8AE756CB4211CAC1" modified="2011-10-19" version="1">MCRLFLCGYSIASLMFSILTKCWSLTVCIMRSWLHNCLSNWRCCSDMPMSQSFSLSHCRLDLMMSVRGAHADMPRSIVRGICPQDISSHTRMYEFSLRVSLLTSKRFFVSPGFLENQPRMTRVRVLAVGSHFKRIRPYASPSPCSASHGSSRTPLCYLFHLEQSVAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFQ9</accession>
    <name>F9WFQ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 417</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002178">
        <property type="protein sequence ID" value="CCD16136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10870"/>
    <dbReference type="OMA" id="VQQIPVN"/>
    <dbReference type="OrthoDB" id="1653485at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1573"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1764" mass="186262" checksum="3A8ABDACEBF4BF5F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ7</accession>
    <name>F9WFZ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 444</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002208">
        <property type="protein sequence ID" value="CCD16227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11750"/>
    <dbReference type="OMA" id="VMNKITA"/>
    <dbReference type="OrthoDB" id="1663771at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="426" mass="47741" checksum="94AF2B8A73F0655A" modified="2011-10-19" version="1">MEGRGAKRTRDETEGEAVAPVVQAPARGEVATATDAVVRHAAVTHEYAVRPSGRWTLDSHVEDVLMERCGGLGDMSLHDFLMKHFGETFGSPCVSMRVFMDNPTLCVSDDAVLRRITNSSPYREYELYKTMREGVDRLSAKGIISLRQWKSAAAANEVEDVGAYVRGVLNAALAIAMRVGNAPSGLEIDGVYDAVFNARWSYVVMSDEYSGKWLGMGVLDVAPGEQPHLWSEAQADVPYDPEEPWEGDEVSGVSGKLVMAVLSSERGWPYGNFQRNEMPDTSTLTEYDAACDAYIRRENLRVWHIVKKWLGMWMESGRVVRPFIVIGTPGIGKSFATGSLLLYQLLHYPSDDLKVLAYFVEGKAYIFHREERRVVYYEEQRVALRNVNDIIRRGVKGYIIFDISENSVHIGDLPYAWGMSLFHHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG00</accession>
    <name>F9WG00_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_11780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002210">
        <property type="protein sequence ID" value="CCD16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11780"/>
    <dbReference type="OrthoDB" id="1490656at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="662" mass="72730" checksum="37A8378DDD70481A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG73</accession>
    <name>F9WG73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">65 kDa invariant surface glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_12460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002242">
        <property type="protein sequence ID" value="CCD16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12460"/>
    <dbReference type="OMA" id="HYETHRR"/>
    <dbReference type="OrthoDB" id="1665249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390329" evidence="3">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46109" checksum="352DEAAA320F5BF9" modified="2011-10-19" version="1">MHGLICVVPLWITLIVSKEASGNNGDGVCKLNENAAGLLCAIAKLVEKARNITHNYDYRDIDGTWGNVELHKVQVDYRVDKLPSITEEAIKKGTLTEKDSEELKKTYLDAHKKNNEQHSKSKAAMDTHNKTHEAAKNSTSKALGEVHIQGNCLSTVSLLGILQCHVKGEQRQGDVNIETLCNGMNYQKHLTEHFGNNIADCNRIGKGKTYCNGTGAALRAALDKWNTTDRKKAVTSSGTTSETCTVKSDWEEHARNAKEHMLKLDEHVQTIHDANLLTTAYFSVIDKIKNDIEKGKPMNEIVANARKAAQEGAKVVVEKPSADTGNDSHESTKPVEEEVKVNVQLDGLQFDDDNMPAHSKESFPKIYIYLLAILLPLCCLVIGVTMFCILRRAKSTPVEKSIPVEGATMSKAGGTHAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF7</accession>
    <name>F9WGF7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 497</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_13170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002267">
        <property type="protein sequence ID" value="CCD16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13170"/>
    <dbReference type="OMA" id="FGISCEK"/>
    <dbReference type="OrthoDB" id="1436090at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17598" checksum="8D059AD4F9BD577C" modified="2011-10-19" version="1">MPAKAASTKKVTKPVSSASKKGAVAPVAKPMKVVKVTKRKAYTRPQFRRPHTYRRPATVKPSSNVSAIKNKWDAFRIIRYPLTTDKAMKKIEENNTLTFIVDSRANKTEIKKAIRKLYQVKTVKVNTLIRPDGLKKAYIRLSASDDALDTANKMGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGJ8</accession>
    <name>F9WGJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_13570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002278">
        <property type="protein sequence ID" value="CCD16435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13570"/>
    <dbReference type="OrthoDB" id="1676544at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390352" evidence="5">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="62"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="38624" checksum="5135A7DB33F1239A" modified="2011-10-19" version="1">MNRTMKIWIIAILCASVVGVCAQESGEPTEKTDHNKEEHEILCGVLKAAVGKWGTSGEGLSDPLKKALGRTIFGSESGGTLEALKDLPGDYTERGAIRGNFCGQPYEEPKFYSAPHRWSGFSAPHNLVCLCTKGENGWPVNSSDNQDTLCGKTRDALGGGNKGWTGNNTGQAQMKATWKNVVTECLEGGRQKSGNLEEALNNFLNKLQHKPDGETNPSRYILGENNVTEKDYDACTGYPKRGVCVAYFNATYPMPWWTDLQNALPEEEKFQEEKKKREEEERRKQKEREQRTDEPQAESLKSGTQTNNQTEKSQKDSLHEAIRKYNTTSSTPISTPSSWLLRAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN5</accession>
    <name>F9WGN5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002297">
        <property type="protein sequence ID" value="CCD16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01630"/>
    <dbReference type="OMA" id="GFRRPYV"/>
    <dbReference type="OrthoDB" id="1412946at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="212" mass="22725" checksum="2299770EBD420D23" modified="2011-10-19" version="1">MASNPSDGDNALFNTEVDPEAELAEMQRQVNDLQEDLRLKALQETAAQDEGQRKSTGNTFSKNASVFVGGMDPRTTESDLRVFFSGCGTIKRLTMLRDKFTGQQKGTAYIEFDTVEQATSAIVKNGQSLHGKPLTVAVKRDNVPAFQRGRGGAPGFPRGGYRGGGANAIQQQMAMAATMMATMMGAPNAVGFNPFHSRGRGRGRGRGRGGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH23</accession>
    <name>F9WH23_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002362">
        <property type="protein sequence ID" value="CCD16612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14171" checksum="B3E3E64F2A77DEF3" modified="2011-10-19" version="1">MLLDGGVGYRGEADDKGKISGDMKAPGEHGDIASTLRFAFPSHLHKVVGGHPFDEAKKHFLPEPGVHKGALVVFKYWWTPDVGRLLHQPAGPVVLCQHPEGDVHPFEAVTPSSSPRCLCFPSSLRTIALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH54</accession>
    <name>F9WH54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002377">
        <property type="protein sequence ID" value="CCD16643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15510"/>
    <dbReference type="OrthoDB" id="1688873at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="28433" checksum="B8A548DEEE106D11" modified="2011-10-19" version="1">MCSTSKPHLSNASTHAWKLQSQLHTWTTFLSTLVIVSAPSQAKPGSLIRCTTPAWLWALTSLHSGHMKGSLRRNSTRDGCGCSVFSSVVAFTYALSKLSVTACPSQPLFPLAVCLSQPKLQWVPVPRSEERVLRLLSRRIYAMLLQPPPNAVQSSPQRLHGQLPVGISAHNCKVICKESIQQSRNPVQSLTQRVHRNYNEHQRSQYRPLWYSAREPMPTDSLLPTCTSAVLLSRKLATHATSCGPTRSPTSALTMQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH69</accession>
    <name>F9WH69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_01740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002386">
        <property type="protein sequence ID" value="CCD16658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01740"/>
    <dbReference type="OMA" id="LVDIKWI"/>
    <dbReference type="OrthoDB" id="916876at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="532" mass="57091" checksum="4FE97B9F709BF4C0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH83</accession>
    <name>F9WH83_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_15790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002394">
        <property type="protein sequence ID" value="CCD16672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15790"/>
    <dbReference type="OrthoDB" id="1671735at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390384" evidence="5">
        <location>
            <begin position="21"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38943" checksum="60F7F74143DA01C0" modified="2011-10-19" version="1">MMKFLFFVTVVILGVANATADKEKHKDHNEAEHKALCNLLKAAVTKWGDSGETLSDPLKKALGKTIFGEGAKQDLSVLREGMPVVYMDVLKVPGSRSVACGQRYNDAGGELSGILEEQPRWSGHSAPHDLVCLCTAGSHGWPVNESSQKDRLCGKDRGALKAEGSKGWGGMNAGYAVQWSEQIQATWENVTKECLNADGQSYNLKDFIEKFKEKLGPEQHDVMKRPRRQLGQGQPDRYGACDGSEKQGVCVMYYESAGHTPWWVDLEKALIEDENLQKQREEEAKKRQKELEQKQELPKTEASKSAPPTNNQTERHQNNNITDTIRKFNLTSGTLITTPCSWLISAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH85</accession>
    <name>F9WH85_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 613</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002395">
        <property type="protein sequence ID" value="CCD16674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15810"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="22728" checksum="42CCB6E71EB2BAE6" modified="2011-10-19" version="1">MVGVGMEVIAPSKSARVLPARGKARWDEFRLISDKLLSQRMKRSVKGVDALNEAVKKGVRQASKRKRRKGNARALLFWTPELTKLDVMVQQCRNERKRDTRIRWRRKLTEGTAIRRWEDNKSRRTVTYPISWNLVKPIYAPRPLPSPVLVVDRHPRTKYQQHRHWHWQGCTGSGYSRHRKRRTCKSRAPCMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH93</accession>
    <name>F9WH93_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_15890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002398">
        <property type="protein sequence ID" value="CCD16682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15890"/>
    <dbReference type="OrthoDB" id="1672886at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="316" mass="36285" checksum="86450A6E93ADF5E1" modified="2011-10-19" version="1">MEKSRVRVISRSAEVINGLYDYVSYARWICVITGRVCKNEPHTMRLLNAERVVPCLWPRGDVDITPELGQSYGIEERLVMSEKAQVAAVLSSALGWPNRMHVPQQPLKALPAPQGEGSDYTHLYIRKDMMSGWHIVEEQLDRWLKPNDCRMPQCYITIDTAGIGKTRGLGPFLHCQLLHHSSEELCALTYFSKVEICILYRHKGATPGMVVYYNVQDGISETERMATQCRRGYTIFDEYKKDIFPYSFPPCWGALVMSTPSPDRFEHWINRDHTLPTSINCYSNLEFRAVRAFGRLSELCQEAPPGAETVEWFKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHJ7</accession>
    <name>F9WHJ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 659</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002447">
        <property type="protein sequence ID" value="CCD16790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16900"/>
    <dbReference type="OrthoDB" id="129480at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="TRAPP_II_complex_Trs120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="PTHR21512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="797" mass="88335" checksum="5FDFC00B560BF59D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHK8</accession>
    <name>F9WHK8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 663</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_17010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002451">
        <property type="protein sequence ID" value="CCD16801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17010"/>
    <dbReference type="OMA" id="KLICTPT"/>
    <dbReference type="OrthoDB" id="814824at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="PTHR13408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="317" mass="34417" checksum="9681A3A9FD3CEC46" modified="2011-10-19" version="1">MPPKLPNLKFKPRHVVRPKEEPDISDSSTALDNLSIVQLERLRRQREAAFEEQQRGSERRQDEGHGATALANPDKGPDITAPHGSGSIARGGRPRGSAASAVAALAHNYSNLPAEAERFGENTMSSILNMESDCPGAVVYHPIPLDGCPHAGARYQNDGMTEEEGRGDVGLPSENDGVAFLKGYSKELENSRKDNLRFERDILRASASTDVDRRDIGDLVWLQLPRFQADAPFKLSNLPPGKVGEIKVYRSGRMVMEISGVSYDMTVEGLSSGGGEACNVVSAVTAAQQPTDMARCYQLGFLSRKLVCMPNINVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI88</accession>
    <name>F9WI88_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 747</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002545">
        <property type="protein sequence ID" value="CCD17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18920"/>
    <dbReference type="OMA" id="AWEQWIY"/>
    <dbReference type="OrthoDB" id="722805at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
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    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="PTHR12616"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="730"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="957" mass="106773" checksum="826FBA497BA10581" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI98</accession>
    <name>F9WI98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">TCIL3000_0_19020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002551">
        <property type="protein sequence ID" value="CCD17043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14525" checksum="EC74BECC0A3EF645" modified="2011-10-19" version="1">MAFLFRQAWSPSIHHRSKYHYHFSPTITLGATLPHCAVMIETPARNVFSQSRHLPQSPNITMKSSGNSWCVWGTRMESDRHCLNSVRTFGTQCPSTYACYLPVDCMSCLTMIHKNRKVGGREFPLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIA7</accession>
    <name>F9WIA7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002556">
        <property type="protein sequence ID" value="CCD17053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19100"/>
    <dbReference type="OMA" id="NTRMTTE"/>
    <dbReference type="OrthoDB" id="631107at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="42"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="183"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="472" mass="52464" checksum="67413CD3232EE7EF" modified="2011-10-19" version="1">MLRRCFPRLGITSTMVKDNYTLSTLSNGLRVLTCDDGNGITGMGLFMLNGAKFENSDCAGAAAVFETLPLQSNQIYTDREISHALSGLGNAFKVTNNKEAISVILMMPRYHQRDGLDLLNSMCLHPTRDEEQFRIAKERTFERALLCDRDATSVCFELVHEAGWNGKGLGHPLNPKKEDLERLTLQNFTAFHRACTRPERTVLAATGVSDHKSFAEEAERALKFEPLQTSGSSSQSVPQFEAGYFPYTGGSRLEHHMEAPESMNKFQEKNLSHVALFLQGVPINHPDYYNISVIQTLLGGGTSFSSGGPGKGMQTKLFREVLNREGFLHGLECITAWYSDGGLFGLYGTAPHEAVMSLLNVMVYQAASICQRVSPKHLEMAKNQLRSQLILLGEGREQLLSDMGFHLVVHNHIITATETMEGTRNITLDDLKRVCADMIKKPVTFAVYGDTSKMPSHEALEEVLRSTYNKMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIV8</accession>
    <name>F9WIV8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 837</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_20910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20910"/>
    <dbReference type="OrthoDB" id="1689730at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395091" evidence="9">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD17257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="269" mass="28833" checksum="A2A65DE1A6AA882A" modified="2011-10-19" version="1" fragment="single">MLTEPRVAWWLLVTVLMLRSYVALGTGPKAIPTKAGAAICTLSRTLKDVTPWATQQVEEGSTKVTHLEMKLLEWQSKFIQSKSKGIGSEECKVTGLLFRQVRKEINKARAEVEKLEKEASKAAAFAANSAGRLDEFITVFANAKGSDSKYCLGSEKAATAGDLKDCFSGNDFREESLVDIGEKASDKELNLNSDIEGIKHSKLSSHFSGTSSTNAGCNLIKGDTGGILKSVGLEKSLWWGGGILTIGKAFGGEFSSSTFGPGEIANDTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIX2</accession>
    <name>F9WIX2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WGS project CAEQ00000000 data, annotated contig 843</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TCIL3000_0_21040</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">IL3000</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002651">
        <property type="protein sequence ID" value="CCD17271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21040"/>
    <dbReference type="OMA" id="QNDIYCL"/>
    <dbReference type="OrthoDB" id="858812at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="12">
        <location>
            <begin position="215"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="BK_channel_a" evidence="11">
        <location>
            <begin position="440"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CCD17271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="921" mass="103892" checksum="F1EA3F5ECAE60E8D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIZ7</accession>
    <name>F9WIZ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_21260</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002667">
        <property type="protein sequence ID" value="CCD17298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21260"/>
    <dbReference type="OrthoDB" id="1674360at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="64"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="287"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="41678" checksum="7C19338DBF27988A" modified="2011-10-19" version="1">MKMSWRFLFKDCFSVFIVKERERRMIKFWIIVCFLVLGVCAQDSVTNHNGAQHEALCDLLKIAAHKWEKARETLSPPLKKALARTLFGKEDGELGELKDLPGDYSTAGGLRDLWCGQPRHEQRYYDNEHQVRWSGHSAPHDMVCLCTAGKDGWPINGTGKTERLCGKSSSDLKAEEGDKGWDSDTQEKEEHGKTQIKATWENVTSDCLLGVVKGERLREALKDFTDKLVLKPIEGQESRKQLGEGNPGVSHACTGSKTYGVCVMYYPKLTPKTWWVELENAIQEDEKIQEQKKREEEEKLREQEDAEKQDARKTETLKSTLTTTNQTDQQHRNDNFTEKLRKFNLTGSSSIILPPSWLLSFAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ69</accession>
    <name>F9WJ69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 877</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002689">
        <property type="protein sequence ID" value="CCD17372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21950"/>
    <dbReference type="OrthoDB" id="1393050at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="297" mass="33745" checksum="CF61DBF3C7F23DD3" modified="2011-10-19" version="1">MRRQFGPVVGPGNRVNPHMDRIRKAKKSTLTQLSHKRGYVAAPSGGTLPALTPMTPVNNGVAPRRYLMNPPPYLQQCEPLVTNGSYNAHERGPPTAMRFGVALQERNESQNVENADMEAENKVTPGVITPPCTSPRRKIEEGSPLKEMLRRIILLEFASKCSERSITIVQTICEVMCKNPAEVVEVMLALEACFCEAVKEQKQQRLLNYWYIVDAIMKLFRDKPDMLEAIFIALPHLLLLYVPWSNSNLAKEHWMVRDRDAESYENLFRVWEYTVPEKITNDIKNLWKNGLPGVGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ89</accession>
    <name>F9WJ89_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 886</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002699">
        <property type="protein sequence ID" value="CCD17393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="51773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="518" mass="57245" checksum="93719C11D7F66025" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ94</accession>
    <name>F9WJ94_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_22190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002701">
        <property type="protein sequence ID" value="CCD17398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13250" checksum="8CA0B591482219E7" modified="2011-10-19" version="1">MVQHTAIIALVPIYIILCSILYFCLPLADLFYWLSLLPAFFSFGKERDAVYIHTLLYCKGIIGFDHILDVWLSCCILSGHAWTTLQQIIVDIKPFRIQRHCKILVPQHHCICSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP7</accession>
    <name>F9WJP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 934</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002751">
        <property type="protein sequence ID" value="CCD17554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23680"/>
    <dbReference type="OMA" id="PHLRIVC"/>
    <dbReference type="OrthoDB" id="101173at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1083" mass="116998" checksum="08EB4DDE12362205" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJR3</accession>
    <name>F9WJR3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 939</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002757">
        <property type="protein sequence ID" value="CCD17571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23820"/>
    <dbReference type="OrthoDB" id="840669at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16814" checksum="0F7C41CB6365D103" modified="2011-10-19" version="1">MEFLSRLEQASPLIECLPATCILHESVPLAELDLNVVRKENIVSLRRTVHFNFRSSAVFRHHIANAGENSRVAVDGFTVWFDVASRGLVLSTSPYAAPTHWKQTTILLPLEVRSAESVAFSVDDEELSVDMHICASDDTLRSYTLELELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJS7</accession>
    <name>F9WJS7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_02530a</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002764">
        <property type="protein sequence ID" value="CCD17585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02530a"/>
    <dbReference type="OMA" id="CARHISW"/>
    <dbReference type="OrthoDB" id="1667028at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390502" evidence="4">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="82"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="27570" checksum="54C5643769B45041" modified="2011-10-19" version="1" fragment="single">MMKLFMVMMVVMGSLVREWRVMANAKDSVAQGDNSEYFSLLCRIYNVAQHPPIKHVDTKEYQKIVDDIDALSASANGKEGVKTQSEETKSAQTQLVGITRDAHKLLDEIKRINPEREAEMARNALNQVIFGEHGKEGDLSPGTLNGVRGRMAACGSRPLDKKGESAGKNLVVDFFCLCAKHDEAEGVDNVCGVSVGNGKDSGWDGVKLVSQDTLWDEVKNGCGTFAKQGVTSTQDGYSLHREFMAKVKAGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX0</accession>
    <name>F9WJX0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002783">
        <property type="protein sequence ID" value="CCD17630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24360"/>
    <dbReference type="OrthoDB" id="1669945at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="532" mass="62497" checksum="EC7EE8D20FDEDC94" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK38</accession>
    <name>F9WK38_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 984</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_24850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002807">
        <property type="protein sequence ID" value="CCD17699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24850"/>
    <dbReference type="OMA" id="CVTAEPL"/>
    <dbReference type="OrthoDB" id="885824at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="PTHR11767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0630">Potassium</keyword>
    <keyword evidence="2 7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <keyword evidence="3 7" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD17699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="578" mass="63363" checksum="300B51E56379CDB8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK64</accession>
    <name>F9WK64_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 991</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_25090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002815">
        <property type="protein sequence ID" value="CCD17725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25090"/>
    <dbReference type="OMA" id="TGRIAQC"/>
    <dbReference type="OrthoDB" id="1213902at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="PTHR12547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18947" checksum="27F3C320EB7C764E" modified="2011-10-19" version="1">MARNSKHVEVKPSKYRTSLCEHYQRDKECPYGDRCAFAHGEHQLQTEERNMEILRTTGLRRLDRAPFTIKSPSQSILSESLSSVRTPTTRRQPVFISLPTQAGVDSLSVSNIEEEITDVAEMVNDTSKALGIHKNEARPSCSSRFSSSCSTEHPVRYRHNPYSLYAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3D2</accession>
    <name>F9W3D2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1039</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_26080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000395">
        <property type="protein sequence ID" value="CCD11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26080"/>
    <dbReference type="OMA" id="DRLFQYE"/>
    <dbReference type="OrthoDB" id="1138719at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="400" mass="45314" checksum="C7A49A01C615A8A8" modified="2011-10-19" version="1">MCAKLLAKCVFRASTTRITEEEADQKAMAYSFCGRAAVFSLSAGAVSLLRSSSASGKENMDSVNCSKQLSACMHFVDTHVTKWQTLYSSFPKDENYDVVKNATAIEVLQLEPTYSTGREGDAAVPVLRLFTFLPGVGPKDVYRYITDVKLRRRWDHNYTMFCRWKGEEAETAGMLDSIQRPIEAVARRTRVCDGNTCLLIPDITSRVVESGWFAHGVGNSLLLKFGIAERMFVYERRSVCYTKRGDDDDGLMMYDVLYSGTEYDVQRKRARCADFREWFRTFSEGRNALLGSMYCQHLIIIPISDAVAQLREGVQHLERSGSIVDEKATKAMYKMFMDSIDRFKDKQNLDGTLVIMTSANDAKISNRTPLWVQKVLCNFFSKYAYNQLISTITADNVKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3M8</accession>
    <name>F9W3M8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26980a</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000439">
        <property type="protein sequence ID" value="CCD11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26980a"/>
    <dbReference type="OrthoDB" id="320176at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="394" mass="43310" checksum="04986051829AC527" modified="2011-10-19" version="1" fragment="single">MGKEKLRFVVGGKSVNYEGRPENRAKDLMDILVKMNVEGPVAVQAFHDNIEGSAGLSSEDILRRYSDAKCAYLEKKKKKQGETTEQKAADEKPQMITLTYKGKQFSYEGLLSDKQHAVVELLLKQNATQEAAVETFRNNLPDVTASNDEIWSMVVAAKEAKAARKSAKLKEAEENPTQKADRRQSAGQRQGGVSSTDAIDELAGMSLEERDSISNFIKQVLEQPEVDLTTRLRGEPGTGVSMSMPVQSVSAAGGATADDDAPLGATRTMRGKIAVYCQEENSSANKVLHIAPSTTFEEFTGMVEKKFGKKMAMSFYEGEDVIDMDDDDVFCMFVEMSQSLAQEGKRIKLICAPPETRRVATDDALTDVKGDADAGETTEFKMRPFSNGRVDIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Q2</accession>
    <name>F9W3Q2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000452">
        <property type="protein sequence ID" value="CCD11775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27200"/>
    <dbReference type="OMA" id="TEAFPEY"/>
    <dbReference type="OrthoDB" id="1007172at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="PTHR10504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="SSF55394"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="495" mass="53976" checksum="61F6B7CD800B0687" modified="2011-10-19" version="1">MVAQRQALTPFTLTSRVAFSPSAGSMRGVLLLMCFAGILEELTEFTAAQPTYSKPTAGNLKIAVTDAAIAPVVPMFLKLLTNVVGNIKVPQQELSGVKLEEMQVHDIQFGNMSIKMVGNELLVSLWNITAAVPEARFDYDLFLISCSGKARTDVRDANASLKLMLSIGDDNLPIVTVEDMVVRFLNLAIVPTLEGWCKPADIIANILMKIFERGIVDYLQKHVPVVIEPLVKTLMVDTIRRLPITIVNPPNISDGRMELLLVINPDLPTEGTSTVTDTAELSAPLPERDVAIVCSFAAANNILRLVHRLVNSKALEPFIDIPEIYNSSLAETVYPNVFKLCPNCSLRIVAVLDSAPWLDMEGEEGFVISVGNVTLRLNMLLEGGSSINIMSTTLEAVANVTHLALMENSRADVQLASISVVLDTLTLMNRAPDLTKINGDIRALLNKIIIPVINKHERGVQSPFNLHDPLLLVSNGTYSFGLNAMAEYPLLSSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3V0</accession>
    <name>F9W3V0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000477">
        <property type="protein sequence ID" value="CCD11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="13903" checksum="265ABA0A25999F61" modified="2011-10-19" version="1">MASGRVSLNEVRNITPTKGVVALASPFDLIISLQGNGLLDVATAHICRASKIYSTINQTVMHRGMEQKHSEANDLYLQQAASKQVTTDHLTTIRYLLHVPPAIGDETITQPTTNEKKIIAIQLSRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W483</accession>
    <name>F9W483_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000526">
        <property type="protein sequence ID" value="CCD11971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389777" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11221" checksum="6CEF20C0C6907266" modified="2011-10-19" version="1">MVSCAMVMVMWSLKLTHIANPHNIALCIPQPHAPLSPGNYRHRLHYLDDNGVTYETTPYSRYLSICPISLSLTVPGTALISVSAIAFDVTTVLCERIKYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W494</accession>
    <name>F9W494_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000532">
        <property type="protein sequence ID" value="CCD11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29080"/>
    <dbReference type="OrthoDB" id="1724738at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17325" checksum="F1E7C82D14F6ACD9" modified="2011-10-19" version="1">MLCREACGGLMQPSMRHPFSERCLTPFAGGRGTPRGWRAHNSRFPPFPCFKALNFLGVSPVIYPSHTHTHTRVCPHASFRHNGAAADEIKRRDKHARAGATVTLIAFIGGVYLFFDDCGFNLINVSRCVRGGNSFWNCFLFRSFLLLPLWLNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4J4</accession>
    <name>F9W4J4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_03100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000561">
        <property type="protein sequence ID" value="CCD12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03100"/>
    <dbReference type="OMA" id="IACCSAH"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37334" checksum="43BF7279E41D2306" modified="2011-10-19" version="1">MSNAVSAHHNIIRSLISHHGCYEVKTVGDSFMIACCSAHAAVQLAHDLQQRFLHHNWKTDAIDSFYREAEGTSAEEDAEYRPPTARLDPEVYRQLWNGLRVRVGIHTGLCDIRHDEVTKGYDYYGRAANMAARTESIANGGQVLLTHATYYSLSTAERKHLDVTSLGPVPLGGVSVPVEVYQLNAVPGRTFAALRLDRAVGTLNEDGSGSDVPSVDHLSLYSDGGESAEKVVAVLHSLLGTFTLAQRRRQLTTFCERWHVALPPTREVEWDDDYCLEAMRRLGAKVGHTLNLVAHEQAETTVGSASDAPTIVVSNPTADTPEPELQLNTDSSEEEGEACCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4L4</accession>
    <name>F9W4L4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1200</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000575">
        <property type="protein sequence ID" value="CCD12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30220"/>
    <dbReference type="OrthoDB" id="237875at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="715" mass="77496" checksum="4384AACE0AA4201E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Q1</accession>
    <name>F9W4Q1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1214</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_30590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000590">
        <property type="protein sequence ID" value="CCD12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30590"/>
    <dbReference type="OrthoDB" id="1705003at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20439" checksum="E06DE211E5CF4EE0" modified="2011-10-19" version="1">MRCCHIQQTIALKCDNSIKGESKHHEALRWCDSLEFVQRHPAGSHPPRNRSFRIMPRELAALIYFLHLQPLDWHNGRPKHHAGRFGGVHNFSHLPSGRISRAGKVLLSFSIGAPHPNEELVTCKGLGQISRHFLLMLREAASDSDVTVWQPLSPIGFRFFAFWSSACTWRFSNALASFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4S6</accession>
    <name>F9W4S6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000599">
        <property type="protein sequence ID" value="CCD12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30800"/>
    <dbReference type="OMA" id="DASRRIW"/>
    <dbReference type="OrthoDB" id="102000at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="757" mass="84390" checksum="1B32932B4B3D270F" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W598</accession>
    <name>F9W598_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000683">
        <property type="protein sequence ID" value="CCD12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03340"/>
    <dbReference type="OMA" id="CIEQISV"/>
    <dbReference type="OrthoDB" id="1445983at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="SSF143503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="1">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="375" mass="42865" checksum="16586728E28C5060" modified="2011-10-19" version="1">MWLGILFFPQLGLHTRSRWGMETLALLIGLMHRNASVSCRAKGLATLNRIFENIIDSPQVDKYKRISLTSVTWTNCIVPAFHVFQLIEWLVDLGFDNPDGRGVLLFKCDSFERISDASHSVCFLRSAYDNPPLKCDVKCPEPVEELLSLLRALVSQSDRDLPEGVNVASNSFSSSMVDSFWETLKNNLRVVVLGHQFRRRKQCYVKENTAQPLLPESCLALWTSLHDVAGQLNLLQLEECFTVVDTERFEFCETCAHSRRMCQCGHRATARKLVAERHKSVSNHDGSGHSGINHEIRVVATRLIVDISSCIEQISVLEEDQGMTRKDRLEARRLLTKFNEDGDIGYLHAQWEEWSTRLEDLKKEKGKSFVYLQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5B1</accession>
    <name>F9W5B1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1303</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_32450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000689">
        <property type="protein sequence ID" value="CCD12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32450"/>
    <dbReference type="OMA" id="KHIRDQA"/>
    <dbReference type="OrthoDB" id="865289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018708289" evidence="2">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="91"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37221" checksum="B6BEA962F508364F" modified="2011-10-19" version="1">MRAFVVVLSSFAATLVALGASALLAKDAPVLTKTFVDHINQLNGGMWKAVYNGKMQNITFSEAKRLTGARIQKSSALPPARFTEEQLRTKLPETFDAAEHWPHCPTIREIADQSECRASWAVSTASAISDRYCTVGKGKQLRISAAHLLSCCKDCGDGCKGGFPGFAWRYYVEYGITSSSCQPYPFPRCEHQGAQGNKTPCSKYNFDTPKCNATCTDKAIPLIKYRGNATYLLLHGEEDYKRELYFNGPFVAVFYVYTDLFAYKSGVYRHVDGDFLGGTAVKVVGWGKLNGTPYWKLANSWDTDWGMGGYLLILRGNNECNIEHLGFAGTPEASQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E8</accession>
    <name>F9W5E8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1319</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000707">
        <property type="protein sequence ID" value="CCD12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32800"/>
    <dbReference type="OMA" id="RETLECM"/>
    <dbReference type="OrthoDB" id="1342474at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="412" mass="45601" checksum="3C2D2020E9CB1077" modified="2011-10-19" version="1">MNSEDVSSYKNPIPIKAITLHLFDVYIYVEADAPSLDFVLCYPNSVPEDADGGSGGVSSDRDAVMDYSWLNDSTMPQSDAGDPVDLRIERLIQWIQRSYLDKCADEISGILQSINNKLSFDYDSYLSTLCGAGGRRVEVVYRSLPDYLHLGFSIPLLQSQGEKVCESLESIFALYSKLSRMTAAQTPPLSQVDFSLIILFKVNNDSNNMDVVKEEVAIKAHQTSPLAGMSPAELLSRTIALDNLPLYSHQFYQMLQRDSACMMDFIPVLEEALINKLQEPLHFLQLLEHMSLLCGMPVDINMKSSDDRVPNSAVTRIAMFSFVPPDTNANVTITVHHRNSYTLPNVDVCVAVAGSAPKKTKEARGQIKYPNRMDQEMKTDANFPAAIDVTALSEATVLGCMDTIATLLNSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5U3</accession>
    <name>F9W5U3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 137</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000772">
        <property type="protein sequence ID" value="CCD12546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03470"/>
    <dbReference type="OMA" id="NMARETQ"/>
    <dbReference type="OrthoDB" id="518399at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="492" mass="54659" checksum="196218F94ACEE2B5" modified="2011-10-19" version="1" fragment="single">MKRNVCGVLRRKLCRTPISLFISANITLRSMHYPSAAQRRLAFQQFLNRESAPFVGHDVSDEGAGEAINHCHTEVEDRKVEHNVRRRHVLDLVEVRPLQGKLEEGEEFNENERWETRPGNATREGSRPHKGRRNDRYTRRGCDIDPQQRGARDLLSLQQRAAHAVRNAKNKKLVEECRRAAMTLREIHAALQGSTTVANANACSGNNGSAVPCTGGTTEGRIVPSEAVRFQRLHQLRDTTYHLTAEHFAQFPQGFVLDFLDTIGRIVSLVGDPNMTGHGHVVRRAVRSLFMRRYAESHPDFTSKPPGRKSRSPGSSARVQCETLLPIHYFRLLRSTLFLPPADSLKIRGPLGTAVPVEEFCVRQLYTANNNGACSSASSAAYSLQQLGPARAVRVVSWCMRCGLSSSHPTAQGSTWISSSSTLPPVSDLRIPFGVGKEYTHALLGCFAQPYAENSNESQPPQLLPFSVRELAVLCSAVVYYKISTMEALTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W618</accession>
    <name>F9W618_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_34830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000811">
        <property type="protein sequence ID" value="CCD12621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34830"/>
    <dbReference type="OMA" id="WMDGLEK"/>
    <dbReference type="OrthoDB" id="555110at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039692">
        <property type="entry name" value="CFAP43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14885:SF1">
        <property type="entry name" value="PTHR14885:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="SSF51004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="973"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1416"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1457" mass="165249" checksum="84E92B76D443C693" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D4</accession>
    <name>F9W6D4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_35930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000851">
        <property type="protein sequence ID" value="CCD12739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1669234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389931" evidence="5">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="13"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="382" mass="41694" checksum="07A0446713334627" modified="2011-10-19" version="1" fragment="single">MERVYISLWAFGLLASQAVEAAGDGKNIPQMIVLCNIYKQGVSMKQLSNVTPGPEEPKILSELEKMNMSTLDEAAWGLLRTEEYNEADWKAKKEEFSKKTVSIDRGELSFKRLHIKETAKLANRKINRARLAAIGLKSLLDQEREAVNRNIVEAQRYMNEALYGDGKLAEDDDTFADKRADGCGSHDTAATPGKDSGKSLLNDLVCLCAQGGGDRNGSQGSQPDGLACAGKISAITPSWYSSSVSKQKARAAWTQGIKPLCEKLKTVPATAALLRKNLDRYLAFVSGAAQQLASGGFVVGLSQSNNGICAAGHADAACVAYKAKQDGIEPEIPWVQKAELAVDKLERVEAGRQKLEKLDEQLRVVNRQAWNIYEDLENDETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D8</accession>
    <name>F9W6D8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase B-like</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_35970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01000852">
        <property type="protein sequence ID" value="CCD12743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35970"/>
    <dbReference type="OMA" id="ISQVTMS"/>
    <dbReference type="OrthoDB" id="724258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PTHR12370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388724" description="Phospholipase B-like" evidence="5">
        <location>
            <begin position="32"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="660" mass="73683" checksum="8FE47D235CE2688C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I1</accession>
    <name>F9W6I1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000876">
        <property type="protein sequence ID" value="CCD12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12750" checksum="DE4520462F566010" modified="2011-10-19" version="1">MCLELRRLMSWGASMGGMIAQAVVTQYPHRVETLPPIAAHSSHHVPCGCYFVCCSIRASITIHMHRGGYCHFCRRSLFSRVCKRSFNNPGINDGLRHLGSFLQFFFCTEDVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6R8</accession>
    <name>F9W6R8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1512</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000921">
        <property type="protein sequence ID" value="CCD12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37140"/>
    <dbReference type="OMA" id="LMEVCNT"/>
    <dbReference type="OrthoDB" id="1437702at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="35653" checksum="1DBB1F3AC96CF658" modified="2011-10-19" version="1">MTSPLSCCQSDGKWLVTLLPAGELFSLKSSTVAAADAQGMREGVKTPLPQAPHTLLRVNVKLLQAQLVMRDGHDTPIHTTADRGELWVVYQSKKITAQCTASNVYSKGTYSGKLSHEIRPFSLDITVRDARVAAGTIHAFSIHAHVTTFEVQLSDTFVYQMQRLMRCLEGDSLPLEVDDTEITGEVITPALSSEWRLLNTSLRVDFLLISEVLVIFSYDRSVQPPEDVVFQGSHIGNIFPSIHEAAITLPRVQCKDFRGTSVAEVWNVMCEGVTMELLKQMPQVVSGFVLLPTFSPIKNVIDRIGSFIFRGSGSSPNPQGPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6U4</accession>
    <name>F9W6U4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_37390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000938">
        <property type="protein sequence ID" value="CCD12901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37390"/>
    <dbReference type="OrthoDB" id="1669700at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389940" evidence="9">
        <location>
            <begin position="27"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="38"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD12901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="43215" checksum="BA505B3C920192F8" modified="2011-10-19" version="1">MLMEPRSTWWLFLSVVILLSPDAALCDGPKAIPIKAGEAICTLSKTLKDVTPWATQQVEEGDAKITHLEMKLLEWQSKFIQSKSKGIGSEACKITGLLFRQVRKEIDKTRKEVEILEREASKAAAFSANSAGRLDEFITVFANAKGESNHYCVGSDGAAKPEELKDCFGGNDFSEQSLVDIGEKASVKEPDLDSKIEGIKHQSLSSHFSRVSSATAGCNLIKGKTGGILKSEGLEKSLWWGGGILTIGKDFAGDLASITAGEISDATNITNKDKAFWTADPAQQIVHLKNASDAFKAFKAVQETIQDKVKSIEQKIQSCMGGQEPGENNTEQNATEPTTTTEQTPTSTTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPITQFLGLYLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W749</accession>
    <name>F9W749_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1569</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000984">
        <property type="protein sequence ID" value="CCD13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38300"/>
    <dbReference type="OrthoDB" id="782767at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="298" mass="32503" checksum="EC952803690D6BC1" modified="2011-10-19" version="1">MASKEEATSEEYPQCESSGGSCDSGASPAAIQAIATGNVFSPALSAAIAASGGLKQLEGLRRRVVCDGHFLGEELSPLFCAIQAILKDTLPLQAIGNKGRWKRVVVFLPGVSGTGSSTLTYQRALQRFLYPWRLYFLAADRWLRPTAAAVIDSLSWLETGGVMLLSPEDPLSWLSYLREEAEVVIDCGAASSSKSVCRNKVVHIRLTSEIEIASDLTHPFSTWRPVRELQQHTMEEGFLGRVLAYARVSGTVTYCLRSAAALVEWFNDEHDQEGNVGPHLQQLARLLLACCCRAREGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7D3</accession>
    <name>F9W7D3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001009">
        <property type="protein sequence ID" value="CCD13099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38840"/>
    <dbReference type="OrthoDB" id="1736803at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17517" checksum="7B19E1AE2F5FCE97" modified="2011-10-19" version="1">MHGTHAHTPGTSSDAGCTHTHGRVQQQYTHCASATQHMMHLPHGEEAKAGKPTHMFSFVYFHCNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVYRGAHTASHHALHAHKAHTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K2</accession>
    <name>F9W7K2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1622</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001045">
        <property type="protein sequence ID" value="CCD13169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39430"/>
    <dbReference type="OMA" id="HEHRTAK"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14529">
        <property type="entry name" value="Exo_endo_phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="354"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="578" mass="64248" checksum="2E6F05D3876BCAC5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N4</accession>
    <name>F9W7N4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1634</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001058">
        <property type="protein sequence ID" value="CCD13205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39750"/>
    <dbReference type="OrthoDB" id="1654446at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="823" mass="94055" checksum="0516936E370EFD88" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7U3</accession>
    <name>F9W7U3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_40340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001080">
        <property type="protein sequence ID" value="CCD13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40340"/>
    <dbReference type="OrthoDB" id="1669743at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389922" evidence="5">
        <location>
            <begin position="20"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="53"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="353" mass="39823" checksum="D2A7B5A5B5758F5D" modified="2011-10-19" version="1">MMLMKIWFVMIMMAVGVGAQETETDHNKDAHAALCDLLQAVVSKWRNGGSELSEPLKTALHRTIFGNESGGNLEILRNALPTAYKSEDASRIFSCGEPRENPYHRGNQARWPGHSAPHDMLCLCTVGHGGLPLNGGDPNSKKLCGKNKNDLGASENQGWGTGQEDRRGEKQMEATWDNVTKKCLEDDGRGGDWKDAMYHFIEKLNHKEDVEKGNKYRLGEGEFESYTCSGNINVCVMYHKNTDATKHNYPIPWWSYLKQVLETNEAEQEHMQRREKEKLKQRSQHQHHTQGKEKLQNKNEPRAAALRSAPPATEEAEQTNHENISSTLAPLEDTSGTHIISPYKWFIGAIFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W817</accession>
    <name>F9W817_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001121">
        <property type="protein sequence ID" value="CCD13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04420"/>
    <dbReference type="OMA" id="FPMMSKI"/>
    <dbReference type="OrthoDB" id="1483113at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="PTHR11592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 5" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19529" checksum="2ED962968816E92F" modified="2011-10-19" version="1">MLHSTRKVMAAARTIYDFEVLGGDLKPYNLAQHKGHPLLIYNVASKCGYTKKGYEVATNLYEKYKSTGFTVLAFPCNQFGGQEPGTEKEIKEFACTKFKANFPIMAKVSVNGSDAHPLFEFLKKAKPGILGTTAIKWNFTSFLIDKNGVPVARFSPGASEKEIEEKLTPLLRNSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W827</accession>
    <name>F9W827_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1694</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001124">
        <property type="protein sequence ID" value="CCD13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1541200at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30151" checksum="154EE2C11971817F" modified="2011-10-19" version="1" fragment="single">MNRTTPSRMAHAFLATSGIGSSQHGHRASVMGSGHSEGFTDCVAAPCEMPVVPTAERAVPAGTTEDKCQAILAEVELMSDRLRMAVEERTQMERKTQELMQRADTRVQQLEEMLRKKESELLFMRGSVEALKARVEYYQSRERRALEKDADCEDVQCNKTRKDGKVDRAVMFDGFLNDKGGSCGVADVPGISFPEKRPIDKTEQSETQYNLTVLGSSGRSHVGHSALSWVKFLLERCFSGTDQTKPAEGESVRGTQIVSALSLLSDCKIILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W865</accession>
    <name>F9W865_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001141">
        <property type="protein sequence ID" value="CCD13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41490"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394764" evidence="5">
        <location>
            <begin position="17"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38815" checksum="5D77B01FB3FD6E60" modified="2011-10-19" version="1">MRLILLFLLIGSWTAANDYNKDVFDKLCDITKNAKALLTAHQDHSEFNRSLHEAIYGSVESARFDDNGDVKLGKACSLSASGRSELCNYKKGAITSSGKNGCFADSLFGTFLCLCTPGSGDDRTLCGFGRVGGGVVWLRLTRVDHERVLFKEVWKNIKEQCTGVLPNMLNNENKFESLKTAVKTVTGSLKEIDGYLYLGDGGSVCSGTNKNDFCVAYEKASEKKGTDIPWVKRIYDALEDLQKILQQRQKHRIPKPEPTVHSQLGDSVESVEYKERSDNITNKSDEKDEEAKGKTNTVKSQSISREDLQRRKRNIQKSTETNIASLATDHNEDSTSLTNTNGPLLATLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8C4</accession>
    <name>F9W8C4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1727</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_42050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001161">
        <property type="protein sequence ID" value="CCD13456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42050"/>
    <dbReference type="OMA" id="CYHAAGP"/>
    <dbReference type="OrthoDB" id="1195552at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22920" checksum="AE05738733AAF3CF" modified="2011-10-19" version="1">MVERHMYDGWSYERFRKQRNRAHFLLEEPYRFVTVLLHREKLYAIDSPCYHGAGPLGEGEVVDVEDAHTAGGGSEGSILACLRCPWHSFLISIETGELVEFLPVEQPHDGSADGSYSPEQVMPSYPLQRHRGICDGLRRLSRKGVVQRTHRVSLDETTGILTIEVEDENDMARRPLPSDKVAGDLRNGALTMQIFDIKSRGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8T6</accession>
    <name>F9W8T6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein TCIL3000_7_1690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_43600</name>
        <name evidence="5" type="ORF">TCIL3000_7_1690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575320">
        <property type="protein sequence ID" value="CCC91361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001215">
        <property type="protein sequence ID" value="CCD13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43600"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_7_1690"/>
    <dbReference type="OMA" id="VIRTHCR"/>
    <dbReference type="OrthoDB" id="1390881at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC91361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17435" checksum="FD65A77ACA5A3039" modified="2011-10-19" version="1">MASNITQERYEQLKKERTFHKFTYRGHEIDPLLALSEEEFKALVHARARRRMNRHADRRAPVLLKRLREAKKGVKAGEKPKAVKTHLRDMVITPEMVGSVVGIYNGRQFNAVEIKGEMIGHYLGEFSLTYKPVAHGRPGFGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W927</accession>
    <name>F9W927_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04730"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388849" evidence="5">
        <location>
            <begin position="23"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="37280" checksum="EFC20C21A0699432" modified="2011-10-19" version="1">MMRIKFWMIVCLGVMVIGVSVGLTTVTPMHHNQKEHAALCDVLGTVVAIFESGRGGTKLQRALSRAILGNENGGTGVRALLGTLPQEFHNPGNRHNWCGSCGHGGKDHYPGKSIPHDLLCLCTVGGDGYPFYANSDGAPTLCGKNAKDLLCGQAEGKHCASEARTGWSEQKFDEKVKNHLNATWGTVVKTCLGKKMKFDLDTARNTLMEQLKPKDGYTSPIWARGHTYCGGINGDVCVSYGSCSEIPGFPQWQEGLYEALEKADFTQTELTSAVSHNASTEDGQTDGQYGPNEDYPQGTQQENHGVQQRSKRSTNPTSHHSEQQSCSIPAQPLWLLSELFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W998</accession>
    <name>F9W998_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_44910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001286">
        <property type="protein sequence ID" value="CCD13791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44910"/>
    <dbReference type="OrthoDB" id="1664838at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="472" mass="52817" checksum="301795075D5C54F9" modified="2011-10-19" version="1">MRMAPLHGHCRFAFLISYFSQKIPPQYKAPQKLYGYGLLSSLLFCLFGCKSLVARTMKDTEVIGKGKGRGKGNGKGVWVALLVMVMVAMGMRGVSGSYEDYEKGHNFNGKEHEALCSVFKASADVWEASKGSPLKLDKNLEYGVRQALFGTHDERIPERITEGLPAAYNTYSLQYRGTRCGGCPGGDTNYFAGWSITHDLMCLCTPGYYSEPFYYWILGFIYRETGFRLCGRKREDMVPDQYQGWYSYNGYKQAKGLHSSWKAVVLGCYNKRTKPRGTEGHNLEEKVKKLSEATQHFTTLLKQSGGRPKLGGFEKHHTESDGKDEKSMHVRYGACNDRRQPWWKKLNETLMGKKPEQLIKRPSSASSGAVPAHDRHTRSTGRGMSISQEEGGESKDPGDTNTTTLDDSYTLELDSNSTHADNTSTDTNGMDPHAEDHDDDPGPLTFHYLRSSSRRPRASLLLVSLPLGSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9H9</accession>
    <name>F9W9H9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001312">
        <property type="protein sequence ID" value="CCD13879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1748158at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13189" checksum="69C16D1F793D2470" modified="2011-10-19" version="1">MGSVRCNVLACVYVCSEISKCVRCGVDCGRWRYLYPFEVVVQLFPCVPRLRRCGVAVEWPTSSRCSVARGLSDPTGHFSSAHFLFITTPPRSSQGLCFLHSRHKFVSAFRLSAKGIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9L3</accession>
    <name>F9W9L3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001321">
        <property type="protein sequence ID" value="CCD13915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04970"/>
    <dbReference type="OrthoDB" id="1707747at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19537" checksum="AAFF427758143752" modified="2011-10-19" version="1">MDHSILSACHTSTTYSPTHESMRAHTTCVQMLWNAILFTTVPPTLSWSLCLIPREENGGTSNHKRLLTMSGGSLNCTSCAAWDKERLRHQEPLLLRPETAAPFLLDVQPFLRLSTHCHMLPHYIHTNTASFDCGSFGSLMIPHSACKGDHSHVTWSLLSIAIIPHSHSRITLRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9P7</accession>
    <name>F9W9P7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1884</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_46360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001335">
        <property type="protein sequence ID" value="CCD13951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46360"/>
    <dbReference type="OrthoDB" id="1719167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394627" evidence="8">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20981" checksum="4C89B73EC5875017" modified="2011-10-19" version="1">MEVLLKWRWLLTSSVLMLLAEDILGTGLQAIHTKGGEAICTLSKTLKDITPRTTQQVEDGTANVTHIEMKLLEWLKKWVQSKSKGSFSNACKMTDLLFRRVRKEMDKTRKEVKKLEKKASKAAAFAAHSAGRLDEFMTAVPHARNDGGSNFGPGGPQASTPESWRDCFGGAHFSVERLMDMSERTRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA40</accession>
    <name>F9WA40_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1928</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001384">
        <property type="protein sequence ID" value="CCD14096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47630"/>
    <dbReference type="OrthoDB" id="1778440at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17596" checksum="D09B25F5454595A1" modified="2011-10-19" version="1">MVKMETGTSVITTPCSYFHAVHFILFRKEREREKKKETTTCFSFDSVLVLFFFVIFGLVCFSLYGVVFHCLRGRQGAPAFTWRVDVAIIRFFLSLPNFRCCFCSSKVLRERKEGEARKKGKRKKGRAGKRQVGLFLPFLHRRQSQGKIPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA85</accession>
    <name>F9WA85_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_48010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48010"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="22610" checksum="39C8EF83433653B9" modified="2011-10-19" version="1" fragment="single">MSVDAKIKGRAGVKLSQPKAVADGWEEEMKKEEKIGRLHRDGALDLSWIWETYDAFVEIAEKVKELLKNPEGKAGKGDLKELEKKLKDGQEKWPEYYEMKKNYWRRRLEVVEQGGETDAVEKDLKVQEEEADRLEKELETIEEALAEILAEKTAPKTDAEPDPVLRELTCDVCGKKYVSFKWLKKHVEGQHPGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA98</accession>
    <name>F9WA98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1949</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_48140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C01.098"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48140"/>
    <dbReference type="OMA" id="ADDINAC"/>
    <dbReference type="OrthoDB" id="865289at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018542717" evidence="2">
        <location>
            <begin position="20"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="3">
        <location>
            <begin position="91"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37238" checksum="28CDEC429E794D6F" modified="2011-10-19" version="1">MRAFVVVLSSFAATLVALGASALLAKDAPVLTKTFVDHINQLNGGMWKAVYNGKMQNITFSEAKRLTGARIQKSSGLQPARFTEEQLRTKLPETFDAAEHWPHCPTIREIADQSECRASWAVSTASAISDRYCTVGKGKQLRISAAHLLSCCKDCGDGCKGGFPGFAWRYYVEYGITSSSCQPYPFPRCEHQGAQGNKTPCSKYNFDTPKCNATCTDKAIPLIKYRGNATYLLLHGEEDYKRELYFNGPFVAVFYVYTDLFAYKSGVYRHVDGDFLGGTAVKVVGWGKLNGTPYWKLANSWDTDWGMGGYLLILRGNNECNIEHLGFAGTPEASQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAG0</accession>
    <name>F9WAG0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1970</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_48690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001430">
        <property type="protein sequence ID" value="CCD14222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48690"/>
    <dbReference type="OMA" id="DHIAWPV"/>
    <dbReference type="OrthoDB" id="924636at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="451"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="513" mass="58446" checksum="0671CC86FB6FB22D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAR1</accession>
    <name>F9WAR1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2006</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001470">
        <property type="protein sequence ID" value="CCD14332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49650"/>
    <dbReference type="OMA" id="DITNGGM"/>
    <dbReference type="OrthoDB" id="170203at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec3_C" evidence="6">
        <location>
            <begin position="64"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="594" mass="66277" checksum="5BDB8F049D2062FD" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ8</accession>
    <name>F9WAZ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001509">
        <property type="protein sequence ID" value="CCD14424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15069" checksum="ED97A0A5FB407745" modified="2011-10-19" version="1">MDAVTRSHTFASRQNHRLPTHHMPQPPERFIGAHQPQERRDVAPYAQLCVTLLFGNGASRAQIPHFHFPPPDKANSPRTNITRHIHEESNGRRIKHRLRGSHLTGHRIGSHSEGFDAPPCALLPVPSIHYAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB09</accession>
    <name>F9WB09_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2044</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_50510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001513">
        <property type="protein sequence ID" value="CCD14436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50510"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="372" mass="39361" checksum="BD15ACA7044C22CC" modified="2011-10-19" version="1">MNDLPSRWLNTYPKYGFLYXISRRYSTESNRLWFDEPEDTHSKYAYTVRAERPVGFYVALCNIYVFTTSAPVPQPESTETESEEHNGTNTNETESEELNGTNANETASEELNGTNVNETAGEELNGTNASETAGEELNGTNTNETASEELNGTNTNETASEGLNGTNANETASEELNGTNTNETASEELNGTNTNETASEELNGTNANETASEELNGTNTNETASEGLNGTNANETASEELNGTNANETASEELNGTNTNETASEGLNGTNANETGSEDSSSGVSSTEAPAGKVNGGVLAVAILLPIIAIALLLLLWYFCFRRRDEKEDTPLSLREVYSPAECPSPVEAPLTSEGGGAAEGGSPNASPAVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB22</accession>
    <name>F9WB22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001519">
        <property type="protein sequence ID" value="CCD14451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50640"/>
    <dbReference type="OrthoDB" id="1661647at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="456" mass="50969" checksum="974D901AC210EBC7" modified="2011-10-19" version="1">MVLSFMPVGEPYGGQSSPIYTDTFHSGDSSVVLTYIGNNSRAIRTTEGHRRGADCIVPDRAAATANAMRRDGADRAVDVNARYIDIERAPPKAAGSGMGNQKSHHAAAERRGVSNHLVESPDLSRPEEPLHSSGDEWNETYSEQLREYEKERGETPRINIIGGHNDDCEMSETLHDTVLSDIKATWHRDMPTPTVQIRAEDRYMSSEPTYVSHNVTRRCPQGKEPQPQPAHRQRCKEPTDECLTHTPDAQREPSNPPDDPSAKPSAEDHKNTGPYINTTHYKYTAHYKNTTHYKGGVEHRDPLTSDTHEKNIYISGKGYLEKEGGHQTHVLGRLRNNETVLVLQVPPGGRMKVCRMVLERGHKGECRGETKGSKRYQLTPIHGGSRDRNLMRVTERAERRRRTASKPTSNSHNSGRGAEVRNTDSAPPITPHPLVSTNMPSDKPVVLKQKVFCDCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBE8</accession>
    <name>F9WBE8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2097</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001571">
        <property type="protein sequence ID" value="CCD14580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51840"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="26527" checksum="5F9462C1DA4F4211" modified="2011-10-19" version="1">MRCRPYHNPHATHRIFERGMARCAVGCHLFLFPSPCAYNGLLSSSFKMVRNVFLRVMRRTGRLTGMVWLCAGIVSLLMMLCVLWCTRVGPPPRFREGCFFTTTIHYSTYFRFIPPDVVRTWKAREYLVVMGIPSIDIDARRRLRALQRETWWKYDEVARQRNNFTGEFLPLYLLAPHQDNGYEISESLWKEAAKSHDVIVLPTCDVRPTTRKRWVRVVVGALNRSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT4</accession>
    <name>F9WBT4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2145</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53130"/>
    <dbReference type="OrthoDB" id="1719479at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17288" checksum="00E899B31F4D94AD" modified="2011-10-19" version="1">MSLIISQVLLASSPNITTYLAALCGSLLNVFISVPSPPQWRFCHAGEARDSCFVAVPFLPTRWLSPMPAVTPLHPVLVETYRRRDRAPNAAWGEPALWDPRPPSHTVRLTTSALVYALPPIWKAVSSCTELHCSFASCKLTIKMAAVASTAGSQCLSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBT5</accession>
    <name>F9WBT5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001625">
        <property type="protein sequence ID" value="CCD14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891281at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15041" checksum="CFBB977999D57F47" modified="2011-10-19" version="1">MGPAPFSFDFRPAQNSRVASHVCGLLPIEDGNLTAYFGCEHQMDFVSLRQSMVCLTPRGISDFLRAFEEAGGALRAEWTVLEATESAPCNPPESACAKLVDDNLQVRQNANGQLCVMQRQLAHVQGIIAQEAAQLGGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBV5</accession>
    <name>F9WBV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 215</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001632">
        <property type="protein sequence ID" value="CCD14741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05570"/>
    <dbReference type="OMA" id="WEDPRCL"/>
    <dbReference type="OrthoDB" id="1315147at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="46592" checksum="8B09684B832D60BE" modified="2011-10-19" version="1">MASPRAQVVVVGVWGCSASGKSIIASQLSSMLESPLLPLTMDSFFDEGECERLGVWEDPRCLRAGDFIQCLANIRSMLELYGPTDAPLHEIKEVTQFLHFTPDVAAVPTPAHGRVYDNIGLARDLASQNCSREAATFSTSPLCVSNGVIGSDSTGGAGDELPKVFVVCEGFLLFAYPGLCQLIDCFIFVDSDNEVACMRRFFRGSRRKKGDGRDGYYERILRMRVSRANAKRRADEVVPLCETLPPLFPLVLPKLDYLPPLPSTPGDYRQFWLQHEYKDAPPPTPFGCNSFDDAPYEWLEVKDVDYIHRRLHQWVSTAHTIDFEKASVRYFEFRYWFFYEVLFYHYQLRAICQKNVLTACEQRASQGATNFPIVLHLSNDADTSYEVLRHQISLLVCRVRESNINKGEECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBY9</accession>
    <name>F9WBY9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2163</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53630"/>
    <dbReference type="OrthoDB" id="1697020at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22733" checksum="31533846A9CAF290" modified="2011-10-19" version="1">MKRVLAPRVLNRQEGSVLKLETTRLQGWPLVRGYMPCNPSPNPQLFERVAGMRKGSISGSSWRCIEKKNPWGRALIPTGNAGAEARTHCMWPEDIKQQWKEIFIAAAPHLSQAPSHAMPLSQGHYAPFPKLVKSLSDTSVLHPSVIMNTRLEFMNCMAARRLGDWSDGQPQPQKLGIRAQWPSSDVIPQLLYTLHEEAVSPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ1</accession>
    <name>F9WBZ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15338" checksum="CDADB5180940EBA3" modified="2011-10-19" version="1">MQKKLTRNNPTTSYVNHLHVAPPVEPDIESAPKVFKARLPEPTWSSAHRNSLRLLVGGNPISSGDVSEAQTILFCCHQRFWWRRCPRCKSSLSCSLRKARPSTRSLLEDKAHLHTRSGVVAIRHHLNKTPDTQAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCK7</accession>
    <name>F9WCK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_55670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001736">
        <property type="protein sequence ID" value="CCD15001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55670"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394676" evidence="4">
        <location>
            <begin position="21"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="98"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="46285" checksum="D15670938A30CD77" modified="2011-10-19" version="1">MACFMIVIAVAFFFASSTTGVRGNSAVVQAGDNAEQFSLLCRIYNVAKNPPINYVDVQDPYEIVEEIDSINISVAEEKQFNETEPVDNSSVAQVKPITTREAAVAQATIRRITQKAHTILDEIRKVNATRDIEKVNDEFAQVIFGEGMNESHLCDGALKDVAERGSACGSPGLSSKGKSAGKNLVMDFFCLCAMRIDNNKEGIHDACGMQVGSSSRNGKHGWDTACPATSSTMWASVKKECGKRLQHYPKSTEEGHEVLRDFLKHLETGGFYRWSESNNNHISSDLKAGMLGTGVGAKENKGSDLICDGSRGKSGKTPAGICVYYGPSDWDKNIPWLVKFKAATASVESINNQTATIQRDIENLQTLLHRAEEIYETTKVISEVHNPATQANFHTASKRLTAYSAAWRQHPYAHLILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCN4</accession>
    <name>F9WCN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2251</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001743">
        <property type="protein sequence ID" value="CCD15029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55950"/>
    <dbReference type="OrthoDB" id="1737543at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19020" checksum="7AD2BC317D1E6E4A" modified="2011-10-19" version="1">MSLGRGFPPGIPTNRNNYRGRPVSNLFRQRVVMDEGQTTRRRPTKQASPSSVHSGLTSPFTIAPSAATSLRLFLEKVNCRGKREKEQRSWSRAGRASGNGEKTTPHVPLKSLKKDAETIAAGSRGGEKAKRSRREKREGGNHAAPSSLFFAPPAAQLRADCFPVLQRSVKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCN7</accession>
    <name>F9WCN7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2252</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001745">
        <property type="protein sequence ID" value="CCD15032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55980"/>
    <dbReference type="OMA" id="YSGTHES"/>
    <dbReference type="OrthoDB" id="1661782at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="461" mass="50749" checksum="853D7C9A4B8F23A0" modified="2011-10-19" version="1">MSPRSERRHGQRGICITAESSQSPRAAFPSKVIVTSIRHHLWRNATSLHAPKSEDREELPNSLFVRQGSSDKKCVKFAPAGNSSGTQYDQVVRNSLAAKQPPLLSSVLPPGDRKEVKNPDKVENVSTVCHATSKASNRNKETNGYRKQKITSTDRPGDAVVQEGRPSAAKLQRIRRDYRHPMTYVGRDIYDDPMWSTPLSNGHASRTLSHASSSEDVLRKMLHNKDLSNYSGTHESMDGGSTVVQQLFPDLTHVRNRAPKEHSEVHNFLPSVSTNPDHANSLRVITTTVTRTTKKVHYTAIDEPYVDKGSEQGECAPGKREVSSSSDTGQTGGVPQFGHLIPTLSPSKISPSGSHHKKLGASNWTAESLEVRRKPQCVAQGASERFRTPRLPAQAPLESNATDSPAFVIQRHEQSVDIGGGDAQIREWPHTAQVGNKGQVWQEWAQLPVNSLVSRELFGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCW3</accession>
    <name>F9WCW3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2285</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001781">
        <property type="protein sequence ID" value="CCD15111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56710"/>
    <dbReference type="OMA" id="PREDALC"/>
    <dbReference type="OrthoDB" id="120561at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1139" mass="123915" checksum="195440A213ECCAD8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDK0</accession>
    <name>F9WDK0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_58810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001878">
        <property type="protein sequence ID" value="CCD15354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58810"/>
    <dbReference type="OMA" id="ARVEWFS"/>
    <dbReference type="OrthoDB" id="248505at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="377" mass="43859" checksum="26DF957DDBCAA230" modified="2011-10-19" version="1">MVKNVRLREVRRRRLLCGRVLLCVGKLLFIILLCVLWIICGDRPSKLTEKDSPTTVHYDTYLRLIPPDVVSTWRAREYLVVMGIPSVDVEGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAVHQDNGYDISGLLRKEATKSHDVVILPTSDVRPTTRKRMGEGGSWGPEAQVVMSRKTYLWLQFALHMFPNAPYLVKGDDDMFMRVPQYLADLRVMPWRGLYMGRMYRASLLWTTDDIVFATGACFTLSNDVAQAFVSYKPLAALLSKTYSIWRIMQYFSMSANHEDIMVGRVLQEKLKLEGLITVNVGRCRFHGSRMRGLFTIVTQKSVVVHRIQEEDYQRLWKWFEEHGLPHVPSQIYWFSETQAALVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDM1</accession>
    <name>F9WDM1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001885">
        <property type="protein sequence ID" value="CCD15375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13455" checksum="D05C992A04385FFB" modified="2011-10-19" version="1">MQGLRAVGQRMCRPCNVRASASSGNLSLRVPRRSLLVPGCEGPCEAEWRTHFEFVQLFAAALGGAWSSSWNTRRPEIRGFVAVCASPRGRRALTWKNTGRYLVTFLSGWRGANLLGLGSLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDM4</accession>
    <name>F9WDM4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001888">
        <property type="protein sequence ID" value="CCD15378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="34110at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="PTHR45670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16557" checksum="34F5085D400FC47E" modified="2011-10-19" version="1" fragment="single">MVMTAAGAACVDSRRQIKAVQRLNNNPEKVVEPLNVLCMSLVMGVEPYLRGFDSSRAIPTLVHMAESDRYAYDGEAMMLVFRALSLIMEHVPSSYCILVPYHKRLMRVATQVFARALDGQMEPQSSDMSTLKEESLRLIRFITVDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDP1</accession>
    <name>F9WDP1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_59220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001893">
        <property type="protein sequence ID" value="CCD15395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59220"/>
    <dbReference type="OMA" id="VEMGRCH"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="43825" checksum="418C02C15FEC932F" modified="2011-10-19" version="1">MAKNVRMRVMQKPRRPTGKLLLLCAGIVSLIIILCVLWGTSGCQPNTATEKDSLTPINYDTYLRFIPPDVVSTWRAREFLVVMGIPSVDAEGRQRRRDLQRETCWQYNGVARQRNNFTGELLPLYLLAPHQSNGYEISESLWKEATKSHDVVILPTSDVRPSTRKRIGEGGDWGRAAEVVMSRKTYLWLQFALHMFPNASYIVKGDDDMFMHVPQYLADLRVMPRRGLYMGRFNSYTRFWRSGELWYALGYCTTLSKDVAQAVVSYEPLKRLVRTPYSTWKFFQFLDLAMFYEDVMVGLVLREKIKLDHLVIVNVKECRFHDVPNNLERRITNNSVVLHHIRESYYIELLNYFSLNATPPAPSPIRWVNGYTAILPCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDP8</accession>
    <name>F9WDP8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2387</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001894">
        <property type="protein sequence ID" value="CCD15402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59290"/>
    <dbReference type="OMA" id="NRCAHAS"/>
    <dbReference type="OrthoDB" id="1743908at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18375" checksum="E8822682CF23C9EE" modified="2011-10-19" version="1">MKQSALLWLKEKKNHANGIPEDDEERLCRLKEHRRAFSVSCAKPSAAVVSLIARTLLEQNVTLLDQVDRLRKSAAEEESRQLKQQQLLEKLSNEVLELREQLAVSACDSSRVELQRQEQLQRDTLCIHESDARVGLLCSFAHVALRSARWNTRMMRRGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDU4</accession>
    <name>F9WDU4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2405</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001914">
        <property type="protein sequence ID" value="CCD15448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59680"/>
    <dbReference type="OMA" id="CAERCVC"/>
    <dbReference type="OrthoDB" id="1282620at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="295" mass="32138" checksum="1294A4C1637E9139" modified="2011-10-19" version="1">MDVGSSDEFIVAVVSFVENIVAIGTCGNDGCFNSYNPSLFKLPCAESRTVPAADSATKAFLSEALVADVFPVGAVGRHLCSSYEQLALSLKEYIAFLFTISQQQFGCCRNTLIHCLYLIELLQRRNILFHQSAAVVLHKSCEVQRHCDLLARCGWHGGESTVSTDLSSMTGNAFASEGLSPSGTSSETGQRAPVLRHPTKRLCRACAQSDVFSLQMWNVQVFIAAALLLSMKVNEEALAEADGELLLDQFGRAVSCEAHALRCAERCVCESLWDKLQVTDEGLRSVTRMLSFHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE94</accession>
    <name>F9WE94_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60860"/>
    <dbReference type="OrthoDB" id="1691803at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="225" mass="25320" checksum="767017A59EB358CC" modified="2011-10-19" version="1">MAASLFFTSSIPLTHKHTRARLNLPHTCSGRHTHFSRWELSVRNVAGLIGATRPPSYTLRCFYGRLTLVWWLVFDRAVTWIVIISRSFQHLSEHLQKKGKKCQTLGAHSRSRVTEGCVVSENETCYHIRAARRSHMLLRTASIGRWGIHILLSSIFRWIVLPVNNWSMFCGSIALTSRATALCLPVGDDCFTMVTNSFVKSSGRFDATDVMDGRPLIFLGGALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEE4</accession>
    <name>F9WEE4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 255</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_06690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001999">
        <property type="protein sequence ID" value="CCD15651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06690"/>
    <dbReference type="OMA" id="WAVIAFM"/>
    <dbReference type="OrthoDB" id="1102571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="21503" checksum="40E6223559138343" modified="2011-10-19" version="1">MSLGRKRARSDDAYNVEVSGHPTRATYDSGVQQVHNPRGRSTSPGVNGEFFLIRVNGKSWRVDAAAPFINVTQLLDTPGLLLQDVTVPSCPIVLLPCPRTGNVTVTPNREYKLVKFIGEHLCLAGDLSRNGAHGPESAETNNGKSSNETGKKPSHLDIWPMTELYAFVCYLKDHGGSCLQDFLSLPVDKIQFTIPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEG5</accession>
    <name>F9WEG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002006">
        <property type="protein sequence ID" value="CCD15673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00760"/>
    <dbReference type="OrthoDB" id="1717067at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17786" checksum="3D0596DEB6C28559" modified="2011-10-19" version="1">MICETCCMEYVFYHARAIAPLFRCNMPSLPFLSAGCGEGAGKRSGVECRRAKGGKEKTNVIIMEVVGIALHRTEVEKKRPVCTFFSCKGKTGRSSPTICVLVIHFHFFALACPLHISPNHPRSNEPSLQSKHRAVTMASVAIITTTVMMVRPDMRFRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEH3</accession>
    <name>F9WEH3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 268</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002013">
        <property type="protein sequence ID" value="CCD15683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06970"/>
    <dbReference type="OMA" id="ANYHAMA"/>
    <dbReference type="OrthoDB" id="943474at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="68"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="179"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="379" mass="43234" checksum="A42C578A6EC2EE33" modified="2011-10-19" version="1">MAKRSKSTKERRARRKEKKLLEARIKTSNEKTEEGLALLEPTGRNAQPNYLKATVSLEAAIEIYDENTTAYFLLGECLRGQGEYKKAIERYSQCLQRDPVNIRAIEGRAASHVALSDWSSAFLDYSSIINIDPENDHAYNHRGLCILSTRVPGLRLHSSEFSQCVNDFTTAIRLNEANYYAWANLGRVYEEQGLPEEALRAYSSALKVKEEYQYAQLRRGCLALRVVESSWTYDEEGQVAPQKDSKNDSFSLPLLKSMNDVKEEVLKEIAASDRRKYEEGLLKNAITDLQCLMTDDANKLKYDPWLPLNLGSCFLLQKDINRAEEEFRLVSEIVNARPQLVELGEAEPIQCVDSLLAVLNLRVDVLKKIRSRRFLSDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI8</accession>
    <name>F9WEI8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002019">
        <property type="protein sequence ID" value="CCD15698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07110"/>
    <dbReference type="OMA" id="AMCATEC"/>
    <dbReference type="OrthoDB" id="315731at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="522" mass="57753" checksum="36767CC0608A2296" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEN1</accession>
    <name>F9WEN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00800"/>
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    <dbReference type="Proteomes" id="UP000000702">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="18780" checksum="A8092887130730FE" modified="2011-10-19" version="1">MHESSENSVTGSGNLSAVSGPDGCELHGGFVTCRRGRAGEAANLTAESVTETNQTAASVSRAAIGGFPATPHSVDPISTAFVTIKPQKPKLGRVLERLQVHVEHNKTEMLKQMDRRSRRAVMPSSGTASSDTEKELEGYLPQYFTCTRTLIGMRCSKTKAQQHPVNVADAALREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF06</accession>
    <name>F9WF06_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 335</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_08660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002087">
        <property type="protein sequence ID" value="CCD15872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08660"/>
    <dbReference type="OMA" id="PLLQCYD"/>
    <dbReference type="OrthoDB" id="685468at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="577" mass="68148" checksum="A918C206C3616EA4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF08</accession>
    <name>F9WF08_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 336</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002088">
        <property type="protein sequence ID" value="CCD15874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08680"/>
    <dbReference type="OrthoDB" id="1722532at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16867" checksum="DF2A9AA983BF0526" modified="2011-10-19" version="1">MWFATFRKVLGQRLCDVRMTSLLNLLVQQPSPPMEASSCTVAVCVPKGKRRAAPYFQAVGSKVILLHRRNGMNRNTNVLIRKRYGYLTCPMPEDSATTCMRPTLSHACLPSVMSTHLLLRRAWVCSPSPANSVYSVRGSAEPTTPGVFLIPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL5</accession>
    <name>F9WFL5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002159">
        <property type="protein sequence ID" value="CCD16091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10540"/>
    <dbReference type="OrthoDB" id="1734359at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18744" checksum="F59823889C363C99" modified="2011-10-19" version="1">MRIISIRIHPPVWCAVCVGDRTWWGAAVAPATISKTHLGSRTCPNTRPTCRSLSLVLRRCLRLCTPRKGKKEVSWRRRRALMPPDAYCVRTGSPFSLFFSSSSSFPCFPTCVGRVEEEVCVFGGRRCSGGDMVSACVCTQVCWSRLSQRVAMDDLASYFVEERSKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG05</accession>
    <name>F9WG05_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002211">
        <property type="protein sequence ID" value="CCD16235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11830"/>
    <dbReference type="OMA" id="NLANDWK"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="809" mass="92225" checksum="75908AAA2BC28E5D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG64</accession>
    <name>F9WG64_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002236">
        <property type="protein sequence ID" value="CCD16298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12277" checksum="AF451534ED95A771" modified="2011-10-19" version="1">MLSKHVGELVVCSVIVCSVAFCSALFSLTPRTPRQAWIWFSMLSILVLILSWTALKALKASEAFLRCTICLAGPAFLVALLTVTSAISPAIKLPLLVRSHANFLSIVKMQPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGA1</accession>
    <name>F9WGA1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_12740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12740"/>
    <dbReference type="OrthoDB" id="1683046at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37962" checksum="D4D2586540F989DD" modified="2011-10-19" version="1">MASDTSFATKTYVCVTCFILDVCAYWAVETRFLAPIFMASHYKYITGNEHAEPSSVLFWLNIFTFYNLILFVARALAERPELERLVRGWGLRLRFTLSIVLILAELALIFFLPVLSMSPPYAIVSLCFTTILGTIGKQFLGRTTHTLWDFLLTEKAGGVMRFTAFLVAIVHAALCIIVVVPGTTGESRENTLSLHTVVYAVVLVIALVMVLSLSLIRCTREGFRSAQRAAQKGRVEGINHLIERVGKTRKTLESIRVRLHAQSDPILRNEVQKEHQQAKRETVEAQEDIRRRLKDEASISALSRLAEFEAEWARPLPPEASSDGGNRDVAQSPQAPDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGE9</accession>
    <name>F9WGE9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 495</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002265">
        <property type="protein sequence ID" value="CCD16385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13090"/>
    <dbReference type="OrthoDB" id="1762267at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19903" checksum="C923EFB91FD9C345" modified="2011-10-19" version="1">MNCFLFFLPPVTFHPEHFFFKTQKKKKRTSRQTDSQRSRSKEVTRGKKCHNSPVVPAFIGRMASSLTIACNPPLLSHFFILPTLLFTALFTRPPPAYFLSSSSLTPFSPLQLFPSFSCQLPPFRLQSYNIHPLLYVPSSPSHSFPTPPPPQRISKRKNNNNNKETANRSLSPPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGM4</accession>
    <name>F9WGM4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 518</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_13810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002291">
        <property type="protein sequence ID" value="CCD16461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13810"/>
    <dbReference type="OMA" id="LTERNDC"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="5">
        <location>
            <begin position="441"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="797" mass="89053" checksum="DDCFDA9F257A7D82" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGZ3</accession>
    <name>F9WGZ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002356">
        <property type="protein sequence ID" value="CCD16582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13496" checksum="A427F516D9243223" modified="2011-10-19" version="1">MTGGVKGLMNQGGEARIFLDLALDLGNKRVRFNEHGILTEHGRGWHPSGRSPHGSHIQPGIGASDTASWALYCARVSPGGETRKTCAGWEFKEMAQVGTVGLCIRTCFRKYGAPSRATAQQQTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH07</accession>
    <name>F9WH07_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 579</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002358">
        <property type="protein sequence ID" value="CCD16596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15060"/>
    <dbReference type="OrthoDB" id="1614643at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="514" mass="56868" checksum="14FAAFE0F0D047D9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH67</accession>
    <name>F9WH67_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TCIL3000_0_15640</name>
        <name evidence="14" type="ORF">TCIL3000_9_4710</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL3000</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575322">
        <property type="protein sequence ID" value="CCC93071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002384">
        <property type="protein sequence ID" value="CCD16656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15640"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_9_4710"/>
    <dbReference type="OMA" id="MTSAYGH"/>
    <dbReference type="OrthoDB" id="1036565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="PTHR20900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCC93071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD16656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="226" mass="26526" checksum="6AF98DBD1E0A45E1" modified="2011-10-19" version="1">MTEYLRDLGRAKPGDPMPPINLGPYDNPLLWNMLDPFGADRGHQRRPMSVSRDFMELHDVPIIFRDQCVHRWVPFHRCLKSLKPVTFGTVNCHEFEEAWMVCRAYETYRNQLLKAKFMELTKDYTAEDKKFFPSLLYLSVPTYMNSFYWTMAASQRLSGWDEKDPANPMMWREPNRALMRSEFSPTNWEKGTLTNATGHKLIDDDVVHDMVPGFPLPENKRPEGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHE1</accession>
    <name>F9WHE1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002418">
        <property type="protein sequence ID" value="CCD16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16390"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20145" checksum="7E65CE6F67BC86D6" modified="2011-10-19" version="1">MSQSPSSPSPEGMAQDNTPWSMEKDVVEVLLKGIGDPEKINLYRFLQPAYPFIHSYISRFSLRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHL6</accession>
    <name>F9WHL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002454">
        <property type="protein sequence ID" value="CCD16809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17080"/>
    <dbReference type="OrthoDB" id="1700268at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21389" checksum="38B91937DB165EFD" modified="2011-10-19" version="1">MKRMLAPRVLNRQEGSVLKLETTRLQGWPLVRGYMPCNPCPNPQLFERVAGMRKASISGSSWRCTEKENPWGRALIPAGNAGAEARTHYMWPEDIKQQWKEIFIAAVPHLSQAPSHATPLSQGHYAPLSGACKIPERHKRAPPISDYEHQAGVYGLYGSETIGRLIGRSTTATAAGDQGTMAVVGCHSPAVVHPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN9</accession>
    <name>F9WHN9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 675</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_17230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002465">
        <property type="protein sequence ID" value="CCD16833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17230"/>
    <dbReference type="OMA" id="CEIMSIT"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="200"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="571" mass="63784" checksum="FF82A010C9630B1B" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHQ6</accession>
    <name>F9WHQ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 68</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002475">
        <property type="protein sequence ID" value="CCD16850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01920"/>
    <dbReference type="OMA" id="MGNAETG"/>
    <dbReference type="OrthoDB" id="1288652at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="23861" checksum="E948CD05F45FFA0D" modified="2011-10-19" version="1">MPPPKVPDSASSGVGKKSEGRIKIVSTGPVGVGKSCLVKQYCEGRFVSKYIPTIGIDYGVKTVEVRAPTHLSPTGRLSVRVNFWDMSGCEEYLEIRNEFYRATEGVLLVYDVTNMESFTALNGWVKEMETHMNTKGSDTLVARADPSAPCKVVVCANKIDETTEKGGKKKRMVNEEAGRKWAKDRGYKYFETSACSGVGVEEAFETLFKDVVEAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHR2</accession>
    <name>F9WHR2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 686</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002477">
        <property type="protein sequence ID" value="CCD16856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17410"/>
    <dbReference type="OMA" id="HAVALMP"/>
    <dbReference type="OrthoDB" id="1209592at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="152"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="279" mass="30643" checksum="AA3D0C433607A2CC" modified="2011-10-19" version="1">MDLLCEEINAPPEYIGHVVGERGATIARLQSETGATITILDGCKVHITAEDPTQLRAATECVRQIISDAINPDYEGPDGRRLRKEAAQLASKRAQLFNEATRQREEGNMQQMSALLEQGKQVGEQMKLTNREAAAAIAWYNNEGKGREGNYFDMHGLRVDEALEMLRARVEALRVALKGASGELRVITGVGRHSGPEGAKLRRAAVEFFRAEGLVFEEVSAAEIRATVTAAGPPVGHHQPQREADQPVENVEKKMTGSLGEHQKPQLKKVEETKCCCCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS0</accession>
    <name>F9WHS0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_17490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01002480">
        <property type="protein sequence ID" value="CCD16864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17490"/>
    <dbReference type="OMA" id="WHEGANE"/>
    <dbReference type="OrthoDB" id="1097975at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030509">
        <property type="entry name" value="CK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909:SF409">
        <property type="entry name" value="PTHR11909:SF409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="21478" checksum="E6DA3CEA2446FDEE" modified="2011-10-19" version="1">MVIDLLGPSLEDLFSFCGRRLSLKTTLMLAEQMIARIEFVHSKSIIHRDIKPDNFLMGTGKKGHHVYIIDFGLAKKFRDSRTHQHIPYKEGKSLTGTARYCSINTHIGIEQSRRDDLEGIGYILMYFLRGSLPWQGLKAHTKQERYRRLAKIATFLQSFLTPGVDTCLSSSSEKVVFLLCSSLFSFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI22</accession>
    <name>F9WI22_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_00120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002516">
        <property type="protein sequence ID" value="CCD16967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00120"/>
    <dbReference type="OMA" id="SHEVHIP"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="5">
        <location>
            <begin position="61"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="459" mass="49805" checksum="C7D0ED2F91E47B39" modified="2011-10-19" version="1">MLNVAEPPSNVREPTETLIEMDEGYGSTCTPGGEKGRSECDISVKKESKFTRCINTIIPHGGALSTTFNLGSATLGAGVISLAIAFQMSGVVPSILILIAVTILTIYSVGLMMQAVEITGYNSYAALSRNLFGPGWDYFTVAVTWLFTFGTCVSYVIATGYLVESVLSPSTASGFLLSKAGNRVITSVIWLVGMFSLSLPKEINSLRYASAVAMLFVCYFVVCIIVHSARNGLHDGKLPEGVAMFKSGNRAIEGLSIFMFSYLCHMNCFSIYSEMRNPSARRITIHTAYSMSLCCMVYILAGFFGYTDIGDRKVETVFEIYDVTGDVMMAIAFAGMLLKICVGFSLCMQPARDCCYYIIGWDVNALPTWKNSLFCGTMSLCALILGLFIPDINTVFGLLGSFCGGVLGFCIPALYRMYCGGWDMNRVGVVNYICTYLLLISGVIAVVFGTAASIYNVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI92</accession>
    <name>F9WI92_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Adenylosuccinate lyase</fullName>
            <shortName evidence="8">ASL</shortName>
            <ecNumber evidence="4 8">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_18960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 8"/>
    <dbReference type="EMBL" id="CAEQ01002548">
        <property type="protein sequence ID" value="CCD17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18960"/>
    <dbReference type="OMA" id="TQVNPCD"/>
    <dbReference type="OrthoDB" id="904932at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013539">
        <property type="entry name" value="PurB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08328">
        <property type="entry name" value="ASL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="9">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C" evidence="10">
        <location>
            <begin position="338"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="463" mass="52074" checksum="984E6ACC963472A9" modified="2011-10-19" version="1">MGSVDYSADGPLLALSPLDGRYKHSTQPLRAFFSEFAFFRYRVLVEVEYFIALCKEVPSIVPLRSVTDEQLQKLRKIAVDEFTISNAEEIKKLEKVTNHDIKAVEYFIKERMGSCGLGHVSEFVHFGLTSQDINNTAIPMMIRDAIATLYLPALDGVIKSITSKLPDWDIPMLARTHGQPASPTNLAKEFTVWTERLQEQRRQLLEVRSSGKFGGATGNFNAHLVAYPSVNWRGFGDMFLSKYLGLHRQQMTTQIENYDDLASLCNVCARLHVILVDMCRDVWHYISMGFFKQKVKEGEVGSSAMPHKVNPIDFENAEGNLMVSNALLNFIASKLPISRLQRDLTDSTVLRNIGVPIGHACIAFSSIARGLEKLLVSRETILKDLQTNWAVVAEGIQTVLRRECYPKPYEVLKQLTRGNTDLTERDVRDFINGLTGISDDVRCELLAITPLTYVGYVPNFGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIG2</accession>
    <name>F9WIG2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 784</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_19610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19610"/>
    <dbReference type="OrthoDB" id="1668582at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="433" mass="47031" checksum="5F6F53B5DF09D6EE" modified="2011-10-19" version="1">MLKLGVGIGMMGWVMVMVVVAGGTAGGTGTGSNGECQLNENAAGLLCAIAKLVEKAKNITHNHDYKNVHGTWDYVALHKEQVDYRVDKLPGLIEEAKAKKTLTAKEAEDLTPLYLDAHNKNTQQHNKSKAAIEAHNRTHAEAKNSTAWALGEGYVTGNCNMVSSLLGILQCYVKGSQPEGNPNVETLCKEKSYRLDESHNTLLTNCNKIGKGKTYCNGTGAALKAALDKWNGMDKRKKDTSSGSGSSNENCEVKTGWEERVRKAQEHMSLLDEHVQTIHDAKLLTTAYFSIIDKIKSDVENGQPMKAIVANARKAGQKGAQVVVEKTGDRSPNASHPTAGEKEEVQVTVQLEGLKSLEDEDHDPAHSKESFPKVYIYLLGLLLPLCCLIVCLTLYGVLRKPRSRSSPSHLDDKGSMPVEAATLGKDGSTRVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIH6</accession>
    <name>F9WIH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 792</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002594">
        <property type="protein sequence ID" value="CCD17123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19720"/>
    <dbReference type="OMA" id="GWERIEK"/>
    <dbReference type="OrthoDB" id="1659812at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="507" mass="59112" checksum="53CD23F9C8E8756B" modified="2011-10-19" version="1">MPCDAYIRRENVRARHIVKKNIDEWLRDRGYVHPFIVIGTPGIGKSFATGSLLLYQLLHYKPEWLKVVAYFVSGKAYIFHREERRVVFYKKQQVAVDEVEEMTSKGVKGYIIFDMSGSGAIIDHLPRSWGIVLISSPEASKFHEFTTQRYHTLPIYMNCYEDAEFKAVLVWERHLQVVNNRIELENVNIENDWKVVKKRIDMVEPLPRYVLADKATYERRVTEVDGAMRSMRDDLGYYMDVLDNQSEWRKEGTTHKLVKLVYRKVKGKFECRNRVTSIYVLKELAKKLRQAQLRRSLIYYILCGALEKCACLLEELGLDIFMFKDCADKLVEHFEHLPHENEAKRESVLSQAGLRGRVPTTLSEFASNGQKRELKTGCLYKPLIPNFPLVDGFFVVENVGVKTIVLLQVTKAEEHHTKKRKAADFRDYMGKVFRGWERIEKDYSLEIIYIQHVDSTAIKKRQHCVSSGDATNDTDLALWDRIHQYQVTLNSDIANDFIRHSSDTREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WII6</accession>
    <name>F9WII6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002602">
        <property type="protein sequence ID" value="CCD17134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19810"/>
    <dbReference type="OrthoDB" id="1723714at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17131" checksum="1644843957976A21" modified="2011-10-19" version="1">MSSQSSLTALNTTSFLISTAPLSMGRCRKKSFARLNGKGPQCLDWDSQASTSACTAQQTSAEGWKLFTSKSLADGGDSRSRPAPSHDICEDTFPSSERKPSTAVFSPLASAHGGQALRKDANNQARSATPLQGMAPFPRRPTGSSPRAIKKIPKNSTSEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIT6</accession>
    <name>F9WIT6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 831</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002637">
        <property type="protein sequence ID" value="CCD17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20700"/>
    <dbReference type="OrthoDB" id="1096950at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="257" mass="27892" checksum="5FE0A113C8095982" modified="2011-10-19" version="1">MPMAGADLVELLQVCVLGAMAAQRYIILELLQLDSSDAPRRDVRIADFEPQSLRMLRDRLRHVVTVGVKGQLAHKEGTAANDLVTTADIVTQTVLERALADAFPDMPFTLVGEEDANTSAAIASQVDDCMRRFLVADFPIPLQADLNRHACAESRLICAETYEELRSRIGVFLDPIDGTNCFVDGHWTAPLTLVGITLDGLPVAGVVNRLFYCTIDDVTCGSGAECGSLSYVWNDASTGPFLLHEGRRVHVGARHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIV5</accession>
    <name>F9WIV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_20880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20880"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390448" evidence="6">
        <location>
            <begin position="26"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="36"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="367" mass="40209" checksum="1E1B0A7B2B205AF8" modified="2011-10-19" version="1">MLRTMKVLMLLGIFMEFGIISYVRSYNEDVKDILCTAYTAAEYVMKNMKGTHKTELEKAIYGRNDKALFSKNGSIHLDRKCTSGLNGRGLLCTSNSGGLGGDGCFLESLVGTFFCTCTPGSPIHRIDNLCGVNVNDYTAGTWYGGFTSQEGVKIDLFREVLEKIKKKCTEKSGPSRDVAQEVMNLKEAVDKVREKIEEKGMRGGFFYLGGSGSGACMGQNGNDICAAYRGKRTRADIPWADKIEKVIPNLISAGREKDSKRKALPRDSSPRKTTVTVPEPGESDEIEEQAVQTSSAPEDNSEQHENGEPQTGTSAGPVGSEGDWKRTKINTESSTYVADIPHLATYLNEDGSFFTSKKWPLLATLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ02</accession>
    <name>F9WJ02_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 858</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002668">
        <property type="protein sequence ID" value="CCD17303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21310"/>
    <dbReference type="OrthoDB" id="1717451at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16568" checksum="1D30BD80D19329D8" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTHAPCRGQKPQCGQQLLHAFGFHHVPRVLGCAWCRAMVVTPACGNTRGNCTSAFYFIPSSGSTASQQSPHCLAAHRNGERCGTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJB4</accession>
    <name>F9WJB4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 893</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002706">
        <property type="protein sequence ID" value="CCD17418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22390"/>
    <dbReference type="OrthoDB" id="1588000at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="205" mass="21561" checksum="5B5546D5B869E7F4" modified="2011-10-19" version="1">MWCRSEDLGHPVTFLLQDGDGVATEPVALLDSVLHCVRDAIGKGDICEAAGRVYSPLLVYVSLLDDPCQVPSDLNDECTVIVDEWSPLHLAIILQREDVVSAILEFHWKHGPGVLEGVLSRRKMCLSAPAAPGTVANVPEPVPARGGGVGRVLHRGGHEMGGAMVVFQDSPDGVGTSGGDGDGCLDAVCGSTTCEAVEWLFDSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJC3</accession>
    <name>F9WJC3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 89</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002709">
        <property type="protein sequence ID" value="CCD17427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02460"/>
    <dbReference type="OMA" id="TCPAWQV"/>
    <dbReference type="OrthoDB" id="1071282at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36487" checksum="FA19F42EDD7E9A01" modified="2011-10-19" version="1">MLFQGMTGLRGMSLMLGRPNPLLFVNCHQALTGSSMIIGRRNLWNPFALPRGENTKVTTPIIGRNDLAQQHSILERANKGVVLHNERLLDACLELLSFCGGNDTTDSSDGAAGANLHEEVTSALAAVVGATLHDVGKTPAEQFDRIYEALCLPDVRANPEIQRRLLVVLEAVLPEALFRVFESEDLFTVISDDVAGRKALALFVHALIGVVDVPEGVSREELVFVYLEDVREAFPSLRKSAALMELEKDVTSIVLKSKLFTLLSKLCAEFDVEGSGRIDLSDLQQVTERVLGDKQARMFLDGVRPDKEGKICYMQLVSLLTRPPPRKRPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD7</accession>
    <name>F9WJD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 899</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_22600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002713">
        <property type="protein sequence ID" value="CCD17441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22600"/>
    <dbReference type="OMA" id="CERYEDS"/>
    <dbReference type="OrthoDB" id="1008021at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="PTHR12991"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389222" evidence="3">
        <location>
            <begin position="19"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="736" mass="81065" checksum="BE1DDB6D07341D5D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJI2</accession>
    <name>F9WJI2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_23050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002729">
        <property type="protein sequence ID" value="CCD17487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23050"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="717"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="7">
        <location>
            <begin position="762"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1103" mass="121436" checksum="A5E82B43EB04BB96" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJL9</accession>
    <name>F9WJL9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 928</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002745">
        <property type="protein sequence ID" value="CCD17525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23390"/>
    <dbReference type="OrthoDB" id="1761409at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16882" checksum="20BACDECE7A4C2D7" modified="2011-10-19" version="1" fragment="single">MPPTTHDRQPHQSLHTASRPSKPSPQHASPDFSNFGLITRPGPRRKRKRKKGSMHPTLTTPNPTHTHTYIYIYAYTHIRTHTRPAIPAGSLLDCQHTHAQSKCTHFYVDTFIQPSPHILSPGPHAYCLSHFHTQARVYAHTYIHIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP4</accession>
    <name>F9WJP4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 934</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002751">
        <property type="protein sequence ID" value="CCD17551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23650"/>
    <dbReference type="OMA" id="CTWDRLE"/>
    <dbReference type="OrthoDB" id="831329at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040747">
        <property type="entry name" value="BILBO1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18281">
        <property type="entry name" value="BILBO1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BILBO1_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="278" mass="31977" checksum="A8690892DC1AC48B" modified="2011-10-19" version="1">MNKSVCVCAAADCGGVKVNLRFLFDASELTVSRMLRRATVAFSNYFRRKGIEHEFAANSVVVFNDAHCTWDRLERTTQLFTNSQVYLFQPDTVDVPAAIPEPIDSEQFLDNSDLSGSNLEKRDYVSFMRHTTPRHFSSPRYSFSSPVKSYERRRAASPFGSRWSRANSYVYGVRRPCNVSFEDFPNDKSRFSRSCSFSYSRDIHSTGISDESSHFYQLSGSGGFDTFSSVNHSGVSILREERKKIDRQLSLPLDDMRYSVREETRRIDRIIRSPIRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJU9</accession>
    <name>F9WJU9_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Plastid-encoded RNA polymerase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_24140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002775">
        <property type="protein sequence ID" value="CCD17607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24140"/>
    <dbReference type="OrthoDB" id="834009at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPOLD" evidence="7">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_A_bac" evidence="6">
        <location>
            <begin position="50"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15597" checksum="4ADFF60E81B94662" modified="2011-10-19" version="1" fragment="single">MKVKIVDCKKHEHSAGETLVFQLDEVDNSFANGLRRVLLAEVPVLAVVSVTIVQNTSVLPDEMIAHRIGLVPLYSMKAREMQLAGDCLCGGLGCIKCQITGEMKVRCPSDRHSLQVFTDSLKIDDEQVYPVSSKERGVWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJV1</accession>
    <name>F9WJV1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 956</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002777">
        <property type="protein sequence ID" value="CCD17609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24150"/>
    <dbReference type="OrthoDB" id="517680at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16270" checksum="A3EB3EDE9A93105B" modified="2011-10-19" version="1" fragment="single">MNESSSDEDIFLPIPCAKKLGDDDCSKEEKSGQGLPDTRRYNALQGLSLTPQPTSRSAQRDESHLTRSAFAKQPTTSPHRSQESAVSLPMMQPRLVSSGCTRANTMSQSDRTPVTSDVSGRLTPREQHETRLLFKDRMRFWGSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJZ5</accession>
    <name>F9WJZ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein TCIL3000_11_6050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24600</name>
        <name evidence="1" type="ORF">TCIL3000_11_6050</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="1068625"/>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002794">
        <property type="protein sequence ID" value="CCD17656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.6050"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24600"/>
    <dbReference type="OMA" id="LWISYNN"/>
    <dbReference type="OrthoDB" id="1395642at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC95182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="23942" checksum="FEB8D5A9A7D70097" modified="2011-10-19" version="1">MSGTTIREAITRFEDAEFKRRTADMSEEAKAEAPRVVAAEEPRVLLIGMLPPIVKMDKDIATLVNCEHLALSTNAIEKIGPGLKELKKLKILSLGRNAIRKIEQLDIPNLEQLWLSYNKIDKLTGLDKLKNLKILYMSNNLISSWTEIDRLANQCPELVEALFINNPIYNNAPSQQEYRYMILQRLTRLTKLDGIPVDPEEKEEADRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJZ9</accession>
    <name>F9WJZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 973</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_24640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002795">
        <property type="protein sequence ID" value="CCD17660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24640"/>
    <dbReference type="OrthoDB" id="1319375at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390447" evidence="3">
        <location>
            <begin position="28"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="614" mass="66218" checksum="7B3AA4016A44F531" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3R8</accession>
    <name>F9W3R8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1097</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000459">
        <property type="protein sequence ID" value="CCD11791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27360"/>
    <dbReference type="OrthoDB" id="1721238at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="17255" checksum="A65FFD503700D7BD" modified="2011-10-19" version="1">MRELETGCTYKPLIPNFPLVDGSFVVEGVGPNTIVLLQVTKAKEHHTKRTTVRKFRQCMGKAFECREKVEKACSWEIMNVQHVDSGSIKKRWKCCSSGDAAGDEHLALWENTRQHRVSLNTDIASEFISRGSCWRRDPIRRVRQSRAALLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W458</accession>
    <name>F9W458_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1148</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000517">
        <property type="protein sequence ID" value="CCD11945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28790"/>
    <dbReference type="OrthoDB" id="1695108at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="222" mass="24981" checksum="AD95826E09B6EC09" modified="2011-10-19" version="1">MVFENARNESVTPKFSLEDGEAATPEQLKDCFSGNYFREESLVNIDEKSGDKKLNVDSEIEGIKYNALRSHFTGSSTTEACCNLINRDNGGIIWKTYLEKSLWCGGEILTMSKKFSGDLETSTNLIACEIANITVSKATWTADPAKQIVHLKNVSEVFKAFKIVQRKNKVKVESNEQKIQVELEARNPVRIAWGKIPPNRQQLSKRQTHKPASVKSLRHPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4F3</accession>
    <name>F9W4F3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1176</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000548">
        <property type="protein sequence ID" value="CCD12044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29640"/>
    <dbReference type="OrthoDB" id="1725165at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16925" checksum="D3E1C2FA84586223" modified="2011-10-19" version="1">MPSSRHVRNLIACGLQIVRPPHFPPECKTPHKGASQTIVQQRQKASRGGSPTCQWIGIEKMNKKRRKCKTTSVSQKSQMRGTILSYRGPPSNVALRHKAALQVVKKGPKHQRLQPIPMRVSNSLHPSYEETTFASNSRRTPSHVNNSFPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G6</accession>
    <name>F9W4G6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1178</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_29770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000551">
        <property type="protein sequence ID" value="CCD12058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29770"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18575" checksum="829A3F667062FE7A" modified="2011-10-19" version="1">MEMIAPLESVRVLPTRGKARWDEFRLISDKPTSQRMKESATGAEKVNEAVKKGVGQAAKKAIHKGNARALLFWTPELTKLEIMVQQCRNERKRDALIRWRRNVPAGTSIRPWEDNVPRPTVTDPLSWNLVESIYAPRPLTSPVVVVDRHPRTKCQQHRQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4L1</accession>
    <name>F9W4L1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000572">
        <property type="protein sequence ID" value="CCD12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="125" mass="14987" checksum="B9AEADC3FD0B88C9" modified="2011-10-19" version="1">MRFSISLWASCRFFASVETGVFEKFLRHPQHLSKIIHVICRCIAKRFHFSHNFPVPVFVVCVIRYIRNHALGLLQNSAEQIEFVFARMLAPNSRAQYQRHQRKLHYHSFNLRKKKRIRIFIFSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4V1</accession>
    <name>F9W4V1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1236</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000614">
        <property type="protein sequence ID" value="CCD12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31040"/>
    <dbReference type="OrthoDB" id="132922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="236" mass="25494" checksum="486B2E8CDB850F54" modified="2011-10-19" version="1">MMFGPVSGEGKPESNNRKMLSNRPSLPLLDGSDVTAHPHLPFFSAPHEDGCIDLYSFTGTRCVKTFDCGSSRAATSVAYSVEGNMFVAGLMDGRVAGWRFDVTPAERAALPLFVYHVLPAGGIRTVTFCGDSQSMVAVAGFSYDTGLSDGCGAQEKESSASPLGEEGIEDLRRPEAQKTVRAGLFGFRKAAFCERSATGYLLILDLVLRPGTYACRELPFIPNMQCTWKGWRALCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W515</accession>
    <name>F9W515_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_31620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000644">
        <property type="protein sequence ID" value="CCD12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31620"/>
    <dbReference type="OrthoDB" id="1665531at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="47583" checksum="9AF7A62A43DA6BB1" modified="2011-10-19" version="1">MSVDLRVVFLHGCVFLLRVRGMVPSFSFYIRIVMRELRRIGRGKCVAMLVLAIVMNFVDAYPPGTVFNDGEYKALCGVFHASLDLWNASRESNLKLGAGLEISLSQALFGKESGGSIEDITESLPPEYNNAPHRGWMCGYCSHTEPAHPGKSITHDLMCLCTPGQYAEPFYGYYWLFGFRENGFKLCGKLRQEMGVDLRHGWYSEGRKKQAKGLDMSWKAVIMGCVNSWKNGNITGSPDLSEKLTRLNTTLQEFVSKLYKDDKRRPKLGGTHGDKKESDGTTEQHIHVRYRYCGEPRRGGGRPKRPWWKKMQDVLKKTKSQLFLEHSTPTLPEENEDDTEQGEGQEEDFETVEGGLESGTPEVIKSPKQGENITHTNGPTNSTIWSLNGTDNVNSTYPRLEYLRSSTTITRPLCLLSTSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H1</accession>
    <name>F9W5H1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000712">
        <property type="protein sequence ID" value="CCD12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15736" checksum="1EC5A104B82956BA" modified="2011-10-19" version="1">MSPVRQSYFRPIHTSPSISLCPTLTAAGQVVAADGGLCNAPRQMVRGSHISLAGLKPTHITEHSARLPKALPFTTSGTFSGSHIHTYAAIRMLHAHQWMRPQGLTHLLPGDTISSQHITCHSHLRDSSGHIKHVSDTMWSRTHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H4</accession>
    <name>F9W5H4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1326</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000714">
        <property type="protein sequence ID" value="CCD12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33060"/>
    <dbReference type="OrthoDB" id="1692357at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="277" mass="28655" checksum="7021FAB4865172CF" modified="2011-10-19" version="1">MQTTSTEAPRSTASFVDKLHEATHHLAPSPSSSIRNFVGKVPPASTSVVTQGSQSVVRGETQEESAHTGSSNTVAPHCDDALHDPSYGSFSVTHKKQGVGPKSSGTPGLPPFSEHSMANTSDSQGFDAGLPAVTCSAAIKSGSDAQGNDVIFDNKRNIGTPTSEISESIPMFLNMTKGSKCNSVLLSGSASVCRGIASEKGDIAITCSPKDAFETLIAKVDSFVGSSKENKTVSSLNATSVSSTPSVGGDSDQRHSDSSLYSSLSSRRLSGTRSGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5V0</accession>
    <name>F9W5V0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1381</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000775">
        <property type="protein sequence ID" value="CCD12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34230"/>
    <dbReference type="OrthoDB" id="1743922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="20083" checksum="4CEBD5081AA5AAB1" modified="2011-10-19" version="1">MQYRFSERRLCFFICIFFCCLRFPSFFFFRTSPSSHFRICHICFVFLFFVRYHGELHSTASWGTHCGETCRRTCGGAMKWRLPCYFLIIGTAVANFFDLPTAMQVVAIYMLPLTLCCVIYMQFSLLLLILLKLLLLLLLLLLFWITCSPMYQRVCFVCVCALVEVVCGKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
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        </submittedName>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000777">
        <property type="protein sequence ID" value="CCD12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34250"/>
    <dbReference type="OMA" id="RTHELPQ"/>
    <dbReference type="OrthoDB" id="1352537at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="813"/>
        </location>
    </feature>
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        </location>
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            <begin position="961"/>
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        </location>
    </feature>
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            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <end position="386"/>
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            <end position="440"/>
        </location>
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        <location>
            <begin position="690"/>
            <end position="765"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1255" mass="134370" checksum="9E8ED15E011DAEBB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Y3</accession>
    <name>F9W5Y3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1401</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000798">
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    <dbReference type="Proteomes" id="UP000000702">
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            <begin position="308"/>
            <end position="322"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="467" mass="52286" checksum="5BDE43CECDE5FB08" modified="2011-10-19" version="1">MSVSGVSTSCEGPVRKLCAAGNVDIYDMWLALEPLLEKEQRLPETGQQDFFLVLEQVTTAILFFAYLRLVEMIDLPAPTDGLQDGIRTYEDAVASCIRVREVLDVYVYPALLRLGDAAEGSVSSRGQQSLSLYWLMRGMLCYNLNALSILLSINTQPHTYEERAPIECMEAAIRQSDAAREFAHFPLAPHWAGALLRDYVEGKKFSWQVGAESTDYVSREWRLHVSVDNGGASDTSFGVLPPHQCVTDVALLPAAVMHLWLFFARTLFRSAPADLVRTCGGGAEPNLSHPPVGVASVGVGAPSPPARENKNETKRRAPLNQRKRTTDKLKAFRLEETRQRAVESEIGFWFRWREALATHCLLGLMVNRPSLLDRYYRLLLPHATNAGCPNCTTTPFMRALEELYPVAADHYGPQWRAQQLVALHQQGAQQQGGRSVARLLQNEELSLTGIDHRLRRSVEYYEPHCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W627</accession>
    <name>F9W627_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1417</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_34920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000815">
        <property type="protein sequence ID" value="CCD12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="WRWADAS"/>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1191" mass="133619" checksum="4718846722913A54" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W695</accession>
    <name>F9W695_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 143</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000839">
        <property type="protein sequence ID" value="CCD12700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17075" checksum="1E7DCA8825DB5706" modified="2011-10-19" version="1" fragment="single">MVELAGLVQGFFGIGHGFDHMPAVGQAGKQVMTQQRLIFHHQQFHKVLHCNSTSRQGDIIAALQLLGAQFYAIVVASQVRVAAAIVGLRRGSAQGLAPRRGLGAGVFEADTMDQVAGFLGFLAAKGRKGAIGRLHAGSGAEHGQGQHQLFDRSHGGYLIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6A3</accession>
    <name>F9W6A3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1440</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000841">
        <property type="protein sequence ID" value="CCD12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35650"/>
    <dbReference type="OMA" id="HRECAME"/>
    <dbReference type="OrthoDB" id="145210at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1094" mass="117109" checksum="ADA16D6D69FDC041" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6A6</accession>
    <name>F9W6A6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000843">
        <property type="protein sequence ID" value="CCD12711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35680"/>
    <dbReference type="OrthoDB" id="1666453at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="543" mass="57595" checksum="0AB6BD6E72B79D03" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6F7</accession>
    <name>F9W6F7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1459</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000862">
        <property type="protein sequence ID" value="CCD12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36150"/>
    <dbReference type="OrthoDB" id="893851at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="264" mass="28787" checksum="53338E1982E50AFB" modified="2011-10-19" version="1">MNANVPLPSSDDSTARLTHSCDKHAVTNSLLMAELMSVAPVSGNSVKREGDEQNNNKKRRVGESRNEEVSQALQGLSCLSEHGKWKFRSCRMPGNDFLNPVSATPCGKKDAKVQLLRPSKEVPWPFTLDVVSSPVNSSSDQDGRLHGKCVDDGDAHASFHSSGAGDFISAVAEKEVRMCFDRSWLYGSSPSTADDGKVPSNSATATGPFPTTLSTVDLRHVMQFQRLLEFHGGRLLSLNGCPSHKLDPIRSIARNALRLIVRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N0</accession>
    <name>F9W6N0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36780"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20125" checksum="361E48D02B9615CC" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQQDNPWSMEKDVVEVLLKNIGDPKKINLYRFLQPAYPFIHSYVSRFSITDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLTYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPSQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N5</accession>
    <name>F9W6N5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1492</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_36830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000899">
        <property type="protein sequence ID" value="CCD12842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36830"/>
    <dbReference type="OrthoDB" id="1726051at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16703" checksum="1C4F64BFBF08CFE0" modified="2011-10-19" version="1">MHRTHAHTPSTSSDAGCTHTHGRVQQQDTHCASATQHVMHLPHGEETKAGKPTHTFSFVYFQYNKKGHPVLGLVSGLEAFSREPPCDSVGALALRQTPETRGTAWEFLSYYPILPSRRLRDPFTISHTISSHTQTHVSRGAHTEPPRAACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7E2</accession>
    <name>F9W7E2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_38930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01001012">
        <property type="protein sequence ID" value="CCD13108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38930"/>
    <dbReference type="OMA" id="YTRFKER"/>
    <dbReference type="OrthoDB" id="1153545at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004396">
        <property type="term" value="F:hexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:cellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="PTHR19443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22217" checksum="65A29DD170F37D97" modified="2011-10-19" version="1">MESGNFDSKYRFVLPTTRYDEEIDAASLNKGHQAFEKMISGMYLGEIARRVIVHLASIGCLPAALKTAMGKPWSFESRYAGEISADCMPGLQFTRATIKKLCGIDVHDYQELLAIRDVCRLVRGRAAQLSASFCCAPLVKTHSQGRATVAIDGSVFEKIPAFRRTLQDNISRILGPECDVKAVLAKDGSGLGAAFISALVVNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V6</accession>
    <name>F9W7V6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_40470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001086">
        <property type="protein sequence ID" value="CCD13278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40470"/>
    <dbReference type="OMA" id="CHEVESD"/>
    <dbReference type="OrthoDB" id="1124591at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="236"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="488" mass="56344" checksum="52AE24EEE5288652" modified="2011-10-19" version="1" fragment="single">MPPKGPKAAAPKAGPGRKGPPAAMIAKLKQHMEKQKEEEERLRREQEEEERRLREEERLAEEQRKFEEEERARERQRRKEEERMARKEGTKDSRNDVLQRMAAAGFIVPDVERIREEQKREQEVPRPKQPRPKQVHKPQVVQETKEPEDESSDEDDGLVTEPSDSEEEIDEDDWEAIMDRDDRREKRRAKNEAIRQQRIEAQRQRQEKREEKKKALADAAAAERAKEHVLESVSKLRSPICCVLGHVDTGKTSLLDRIRATNVQGGEAGGITQQIGATFFPRESLFEATQELNKKYKHELNVPGLLVIDTPGHESFTNLRSRGSSLCDIAILVIDIMHGLEPQTRESIRLLRERRCPFIIALNKVDRLYDWEAHKDMDIERTLSMQKDHVRGEFDTRLTQVKQELLQEGLNSELYYRNTEVRKVVSIVPTSAKTGEGISDLILLEVQLVQQFMEGKVTYKDDLQCTILEVKPTTGYGITVDAISQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9W820</accession>
    <name>F9W820_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA wybutosine-synthesizing protein 4</fullName>
            <ecNumber evidence="8">2.1.1.233</ecNumber>
            <ecNumber evidence="7">2.1.1.290</ecNumber>
            <ecNumber evidence="6">2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TCIL3000_0_41040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">IL3000</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine = 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="8"/>
    <dbReference type="EC" id="2.1.1.290" evidence="7"/>
    <dbReference type="EC" id="2.3.1.231" evidence="6"/>
    <dbReference type="EMBL" id="CAEQ01001122">
        <property type="protein sequence ID" value="CCD13346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="YLRILAM"/>
    <dbReference type="OrthoDB" id="1094856at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="PPM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="PTHR13600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="SSF50965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CCD13346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="569" mass="62319" checksum="92C3A4112F796871" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W821</accession>
    <name>F9W821_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_41050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001123">
        <property type="protein sequence ID" value="CCD13347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41050"/>
    <dbReference type="OMA" id="HEATRCM"/>
    <dbReference type="OrthoDB" id="1501660at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043486">
        <property type="term" value="P:histone exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="PTHR13093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="256"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="297" mass="33335" checksum="E1CC1B1EFB8BB672" modified="2011-10-19" version="1">MYWMRRMPSVFAISCLFIFPFVCLLFFSLSPHIALLRAIMTSSRTHNALAHQLQEERLEKLCDDNAFVNVVDVLRRRKHDAFPADGNSTEVDFFEVGTTSATAPPRIHLTRFLLEQHRSYLKAMGLDEDEKQHCDSKAGGDSSSVSTWSSAASSEKSEIVSTSRRGKRGRKRGRSKYGKSRKASQQVPNDSAPPNREDNNRNTVNIASGDSSLLAWECRYIRDWCHAQKVGSAEVQVPTVSYTSMTAPPPLHAGGHHLCSVCLLPAGYRCVRCRRALFCSIECHVVHEATRCMKFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W823</accession>
    <name>F9W823_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_41070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001123">
        <property type="protein sequence ID" value="CCD13349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41070"/>
    <dbReference type="OMA" id="IMTIAEC"/>
    <dbReference type="OrthoDB" id="1532160at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="5">
        <location>
            <begin position="53"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="21064" checksum="7C520307733E3741" modified="2011-10-19" version="1">MKKSIMSVKAPKLFNKWSYDNLQTAEIALSDYITRTPTYVPHSAGRWQKKRFRKARIPIVERLTNGLMFKGRGNGKKLQAVRLVRHTLDIIHLLTDQNPIQVVIDAVSKGAPREDSTRVGAGGVVRRPSRRVSLMRRGNEAIYLMCKGAPRLLSQPENPSRMSCRRDRERVEGQLQFLRLQEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8A2</accession>
    <name>F9W8A2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chloroplast protein-transporting ATPase</fullName>
            <ecNumber evidence="1">7.4.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_41820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CAEQ01001152">
        <property type="protein sequence ID" value="CCD13433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41820"/>
    <dbReference type="OrthoDB" id="374850at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="10">
        <location>
            <begin position="238"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1700"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1709"/>
            <end position="1726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1726" mass="195793" checksum="9EAE7439096D20E2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8I6</accession>
    <name>F9W8I6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase</fullName>
            <ecNumber evidence="7">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_42640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42640"/>
    <dbReference type="OMA" id="FRIQAIV"/>
    <dbReference type="OrthoDB" id="110058at2759"/>
    <dbReference type="BRENDA" id="3.4.11.2">
        <property type="organism ID" value="6523"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="SSF63737"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M1_N" evidence="10">
        <location>
            <begin position="15"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M1" evidence="8">
        <location>
            <begin position="229"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1_C" evidence="9">
        <location>
            <begin position="519"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="866" mass="96779" checksum="D1713A55498F50D0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8K7</accession>
    <name>F9W8K7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001177">
        <property type="protein sequence ID" value="CCD13541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04500"/>
    <dbReference type="OrthoDB" id="1732793at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="15939" checksum="240DC1A7A419EBD8" modified="2011-10-19" version="1">MRSSIESDNAEIGVPKSSPVGNSVVSKTPVSRECSMAQLRLDVSELSAHLGRLEETYKILNSAQLCRQEEFEDEVGALHRAYAAATSGVKSYRSALQDTIRRAEEILGDCHKRGDSSLANRLASGLAEARAVLRLHANGGLASRSGVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W978</accession>
    <name>F9W978_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 183</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_04810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001277">
        <property type="protein sequence ID" value="CCD13769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04810"/>
    <dbReference type="OMA" id="EHQAFYA"/>
    <dbReference type="OrthoDB" id="1457683at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="SSF102848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="SSF54236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="2">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="280" mass="31044" checksum="901F338B7237EC70" modified="2011-10-19" version="1">MEEDKLDRKEDVPDPKDVSSFVGGGPSSGQEVTAVVDKDNVDRTIESLFERARVAVPGKDVSNVQAFYGYGRRIGHTSDTSLFISPVVREQRTVNIYVYRDGYIIDNGPLFDKQGKDSAEFFNTIAQGYIPGRLEAMYPETDISVRLTDYTDVDYKDARESFPGCGKRLDEHVSTSAVAQKARGGEKSTTGSVPVFQLHEGEETAKLAIVNLVGDRQVFTVNPKRHTVEDVYQVAAKFSQVRVGMFKLLIRDVPPRPLEGKCLTIAEAKIENCTLMVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9B8</accession>
    <name>F9W9B8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1845</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001292">
        <property type="protein sequence ID" value="CCD13813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45110"/>
    <dbReference type="OrthoDB" id="1685363at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388866" evidence="1">
        <location>
            <begin position="17"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="300" mass="33311" checksum="5950FF0E4A71E4F6" modified="2011-10-19" version="1">MMKVFWLTMVLGVASANGKKTATCQLDKKEAGALCSLATALEATYKIAEKYDEHSLKEASENMTWLERNFDQSKRALLEHLQELEKTKAYTIEERMLLGVVVVEVARENENLYRSFEEASTHFREHWHKAKAAIKKALGKKEGSSVNCNETQSTLSHFIRCLAPTTSPLGTACEGQETRQNLKEGSGGGILETTLEAAWRWVSLRMRRPSSERPACQSTTVWKNSILEATQHMKDLAEVAQRTEAVRDQSVASLTVVLAIRRGVENGNDLETIALSAEQAIQTGASVKLDEGNTPRTAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9F6</accession>
    <name>F9W9F6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001302">
        <property type="protein sequence ID" value="CCD13856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13495" checksum="C5C93C35B385C188" modified="2011-10-19" version="1">MIDVIDVVGDGSTSASEHSSGTVGLSESAQVIASSLQSLLGTFTGAQRQKALLLFCERWRVTLPQPRGAQGVWDDECCRDVVHRIAGKVGHIVERGERSSSQRSGNTSLSSASVIFINNSLCDFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9K7</accession>
    <name>F9W9K7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1871</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001320">
        <property type="protein sequence ID" value="CCD13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45990"/>
    <dbReference type="OMA" id="EDSWWFF"/>
    <dbReference type="OrthoDB" id="1654150at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1186" mass="126072" checksum="08B2EE616B507899" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9M0</accession>
    <name>F9W9M0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1874</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001324">
        <property type="protein sequence ID" value="CCD13922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46080"/>
    <dbReference type="OrthoDB" id="1703723at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="190" mass="20770" checksum="5656E3F34C18CDC8" modified="2011-10-19" version="1">MIIHSPCTQHIAGIGNPSAVILPSLVCCFSSVLRSTVHTSTPHSSQPPFNRIGRSSSHTATQTALTAYFHFTESYSTPSSNEHTHTSTQVSPNDTHSKHHPLIPKARLQAAHQRHVRPHKPAGIICNPGSKSYALMLEIMKLTSNAYLNIPTRLPHAEVRNLNAGNNCCMLSVSIRCLECPDAHGAGQWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9N1</accession>
    <name>F9W9N1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_04980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001332">
        <property type="protein sequence ID" value="CCD13935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04980"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394791" evidence="5">
        <location>
            <begin position="21"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="87"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="44415" checksum="D58281878AC883FE" modified="2011-10-19" version="1" fragment="single">MVMVNCAFLTLVLCMGICTAQPSATEFNLLCRILVEANDMMLEPDYVYDETKDREIVKEVEVLYNTTTEDMDDFGNSLWETKDLLEKHPPPMQSQNRKLAHRELKKFITEMERKILENRQTTVEVNKKIEEARLPVAQGLYGDKVKEFPKEEGSMTDVRNNTQSIFNDPIAASQSCGNENETGKTLINDLFCVCVGEGDDADGPCHPKIWPPKSWHSNGGQGGWKQIKYGLGTLKVVPSFLESIEKIEKVCKKLIKEKRHTRNMPALLKEYMGMIGLGTNESIKKIFGHSGRQDKSKVTKCTGGSGSDESGSDKEKKNENICVDYTKTIENCKEIPWHKKFKEASDKLNEAKTLEDRILQNCAEIVLLKGKAWAAYSREKDDQTSNLDDVNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Q7</accession>
    <name>F9W9Q7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1885</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_46460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001336">
        <property type="protein sequence ID" value="CCD13961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46460"/>
    <dbReference type="OMA" id="PTHYNYL"/>
    <dbReference type="OrthoDB" id="294094at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021301">
        <property type="entry name" value="DUF2779"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11074">
        <property type="entry name" value="DUF2779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2779" evidence="2">
        <location>
            <begin position="697"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1045" mass="117871" checksum="48F98BDA5F05AE41" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA00</accession>
    <name>F9WA00_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001367">
        <property type="protein sequence ID" value="CCD14055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00530"/>
    <dbReference type="OrthoDB" id="459389at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="SSF50985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="267" mass="29312" checksum="8CDC4D35CCF878FF" modified="2011-10-19" version="1">MEKRVLRRLHTRIVGMGSICGGIPSPMAEVFLRSLPPPAELDPAKYRRFEREEALRSRLPPSSTAPEPFYDIVHGAAGHKHVALITREGNLITFGDNRYGQTAAPVEEQAPSCCDEPTYDRQRPAVARRVTQEVSAAPLYIDLDGAFARGETRVVCGSNYTIVYQPGGRRAIAFGNNHVGQLGIGHKNPVSAVRGFAEWNLAAEWWGGNSSVIHTVTCGFNHAVLQLSSGALLHSAATRGVSWALARPCLPWSQRPFASSRRRGYEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA41</accession>
    <name>F9WA41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1928</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001384">
        <property type="protein sequence ID" value="CCD14097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47640"/>
    <dbReference type="OrthoDB" id="1750752at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="18894" checksum="F7A76FAE5FF7A2CD" modified="2011-10-19" version="1">MFCFFPFPNTIHLVHPLSLRLLIYLFVCLRLSFFLFSFFFFWTYFHPSRVLCAVFPINKYIHIVLLPSQRLRAGEKGVMTVRGSSKKEKQKKEGRCQVVHVPTHKHALLLFGFVVIRLVSRLFVCTCSWRRQGVLRSGNGNNDSFFYKKNYCCYYYQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAA4</accession>
    <name>F9WAA4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001409">
        <property type="protein sequence ID" value="CCD14160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14821" checksum="BB83DE7D1936008A" modified="2011-10-19" version="1">MPRNPQGLFRHAPPFAFCGESCRNHDVSLSRQPDSGSVTYHFQAHSNVRDFYFCMTRKLQFSLLQTRSHVLQPVALALVPAQAFHLGWRKERSELTVLWERRSNSRSLTDDGQRLGTQSNPTSNVFASCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAD7</accession>
    <name>F9WAD7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001417">
        <property type="protein sequence ID" value="CCD14198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48460"/>
    <dbReference type="OrthoDB" id="1665014at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="408" mass="43337" checksum="60F6C085EC4EE480" modified="2011-10-19" version="1">MHGESLATGHACVGSAEADLTPPRNVSRGSNEDGCSADDKDSSECRTSSQVGECSDLTVEGKSASAVVHTMPLRNRGTHSHEGSSSDGGNNCENVYGDSCFVTARSLPGLSVSCTPRTRGVWAGDAVSDGDLTARGFFRSCRSEESAPCSGRWESSSGEGTLGERFHRTIVNNFKIRLPWGLLNASSVEVPMSPTMPSCTSTPRRVVASSCFEDSQCTARDTPLHSLVTSVKFVYDEGSSVTESLPRSSRVPMDYGGGVSARSIAMSDDFRSCQSLAGESAVQSARPSHTNTPGMSSSVTCLTAREGGERDIIAQNNSFDSVVVQQQEDLDTRDQFLGKPSLGFVLRGISRLQNFITLSYGKSNNAGAVEDLLLPEKSDKSFMGFGAVKPLLVASQNKENSAINKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAM1</accession>
    <name>F9WAM1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 199</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_05280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001454">
        <property type="protein sequence ID" value="CCD14291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05280"/>
    <dbReference type="OrthoDB" id="957782at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="275" mass="30984" checksum="196414AC504F9B6F" modified="2011-10-19" version="1">MPVGDLWRDLYEAETLSDASRAVLSSAPRWAPWVGAGAFFISYVGFIRVKIFIGKWRRAARKRAERKFLTISQWQSWETTPAYAELSLTGEGDGGGDGDDDSDVEERCGNGCEDRTMLTLDDIDEFRKSLRLRLPRDNDLLVSIEEMLLVDEIPDGWVLYRTTAGVVRFMNLNTQELAYFPPGQREKEYHIRKELRRRSRLEAARKCTLLCGGDVNSVGHFGVSQAYPADQLLNGSNGDRALSTSRSSGEGQEDRDSQGDAQRHNESSSCEDQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAR9</accession>
    <name>F9WAR9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2010</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001474">
        <property type="protein sequence ID" value="CCD14340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49730"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="155" mass="16592" checksum="AA1378716971DF21" modified="2011-10-19" version="1">MQPGQQIICTNAGNNETHFQCISQHPNTPAPCRGQKPQCGQQLLHAFGLHHVPRVPGCAWCRAVVVTLACGNTRGNCTSAFYFIPSSCSTASQQSPHCLAAYRNGERCDTSHHTHVAATPHYSSSLQWLKCATVACPGAINGSLTPPHILSTLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAT9</accession>
    <name>F9WAT9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_00640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ANT/ATPSC lysine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001480">
        <property type="protein sequence ID" value="CCD14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00640"/>
    <dbReference type="OMA" id="YVLYMYL"/>
    <dbReference type="OrthoDB" id="1605787at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="PTHR13610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23093" checksum="C943DCB60F64722E" modified="2011-10-19" version="1">MPELDLPFQWDDGTCISPFVPTTGDSVVELAAWIDRSVLPRSSTCTMRVTDLGCGDGTPLLVLCAELFSGRGPKYPLEVMAVGFDIDEGLVAKAKRAADEAASVVPPPHILRHNFAVADLRETDIEKYFPVDEADGHVLFLYLLPDALEIIREMLLKVIRRVRMLVSNRWDLPFLCEWKVGQLNTLHIYCYNDEARKTWAQDLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX3</accession>
    <name>F9WAX3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001494">
        <property type="protein sequence ID" value="CCD14397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15732" checksum="6FE1171AE2F841EE" modified="2011-10-19" version="1">MASDTLAGWEARRHECPVCGEHACRIWQLKCLEAVRSGDAASVLKVVLLFRCADAAVVTAVNRQRDMGSEERSYSIFRNEKWCEKYPSQVALRGQAKGHRPNATRMMRELPSGTWMNAGLAHPCYECAPFVTIFPQTKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB60</accession>
    <name>F9WB60_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_51000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001536">
        <property type="protein sequence ID" value="CCD14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51000"/>
    <dbReference type="OrthoDB" id="1671087at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390087" evidence="5">
        <location>
            <begin position="20"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="87"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="37019" checksum="67087AEC2581FB6A" modified="2011-10-19" version="1">MRMTTLWMIICFWVIVVNARKGDTDYNKDDHERLCAVLKAAVGMWGDLQKRQATDPLRKALGRTIFRKEDAEGTVESLRATLPEIYEDVEGTTGARRSLCGGRGSDRSAPDDMICLCTAGDHGWPVNKSESNSGNDKLCGQDSKALKADANQGWGSTAHEGNEHVNATWVQVVIPCLQDDGKKEDLKKVLDTFIENLNHTLDQIFGDIYRLGKGGSENYHECDGTPEHGVCSMYYTTKKPLPWWKVLQEALVQDQGTQKQLAEDKRRQQESEEKQDIPKIAALTSAPPTTNQTDQQHKGSNRTTQFHRLNITGSSSITRPTTWLLNALFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBK5</accession>
    <name>F9WBK5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2115</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001591">
        <property type="protein sequence ID" value="CCD14638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52380"/>
    <dbReference type="OrthoDB" id="1703017at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="202" mass="21841" checksum="B55F1A6C9F379716" modified="2011-10-19" version="1">MRGGALLSLLSRDAQRNGLTVKGENMSNCPVSATGLATSLVSCGIGPASLGDMLLRASPIATRGANSSITLSHIKCTKGLPQILSRNISIPPRHASISSSAIGQRAFSRPTELREASRMLRIIASSFPLAVSLYWFPRLSVFIQHGAVMAESREVGPQFSLTPHRTCDTTNIFNTLCRGLADHFTCRIQYLVSLHRPRKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC01</accession>
    <name>F9WC01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2165</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001647">
        <property type="protein sequence ID" value="CCD14788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53740"/>
    <dbReference type="OMA" id="YEWYRVA"/>
    <dbReference type="OrthoDB" id="996120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="555" mass="63246" checksum="5A57B6451A5365BE" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC73</accession>
    <name>F9WC73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2192</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001677">
        <property type="protein sequence ID" value="CCD14865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54390"/>
    <dbReference type="OrthoDB" id="158627at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16184" checksum="350CB0AD8529D504" modified="2011-10-19" version="1">MAAHIIYPALEDAPTHNYTATRSKGDRECLFSISVYVPADIKRPSAGVVTDKNLHPGEFAFLDVQVGEKGCGGARHRELKGAKNAAVTSDLEDSNEEKATGAEKTEKCVEAEVSATDGEEATERVHVKWLQENPYFPCKPPALCNPVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC99</accession>
    <name>F9WC99_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_54620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001689">
        <property type="protein sequence ID" value="CCD14892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54620"/>
    <dbReference type="OrthoDB" id="221791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="22759" checksum="90D8D35CA7EA1DB7" modified="2011-10-19" version="1">MRQLIEDEKIAQIRKRIRQEIAKALKDEEKTRKDIAQRSIKGLHDLIERCKSEKQRIVKELAERERREQLEHQREQEIIKQAQEQNAEMKRRIEEMKHNITTLLRDKKELGQEIKELRKANEKYTNELNSVTEKKTALEQKVMQHVGKIAESEQRLNELRQGDTPASSPSRAASETAEAIDVVHLRDLLKRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCF4</accession>
    <name>F9WCF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2224</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001713">
        <property type="protein sequence ID" value="CCD14947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55150"/>
    <dbReference type="OMA" id="CNTCFLY"/>
    <dbReference type="OrthoDB" id="64805at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="PTHR45670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="SSF56204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1106" mass="123319" checksum="EDE00ED1996C39A3" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD49</accession>
    <name>F9WD49_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2320</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_57450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001820">
        <property type="protein sequence ID" value="CCD15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57450"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394887" evidence="4">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="49"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19737" checksum="938673706643B88A" modified="2011-10-19" version="1">MMKLWIVALVMSFGGLCATAAKFNAEEHDALCNVLVAAVELWDIEESPESELPSALKTAINQAIFGKEKGGNLEDLYEALPDVYEHPGDREQWCGKCSPRYQRGPYPGKSIPHDLMCLCTPGKEGTPFPRSSSWSRLLGWKRITLCGQRRWELIEEGHVGWYSLTYGSAMCDLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD65</accession>
    <name>F9WD65_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001828">
        <property type="protein sequence ID" value="CCD15216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="116" mass="13020" checksum="7F35D990EDE0F867" modified="2011-10-19" version="1">MRTPCSSIWVELYHSNCHSRTPTDVCVLSEVPLSPRSSTSNNGATRSRCLSVATSNTQSCNYLLRPIATLRTTPAPIPFTFSFTQILISPHAYIHTHTYIYIYARTRLLTAHSPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD77</accession>
    <name>F9WD77_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2332</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_57700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001834">
        <property type="protein sequence ID" value="CCD15228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="167"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="306" mass="34333" checksum="5F104AB7B1A4DFD6" modified="2011-10-19" version="1" fragment="single">MATYQKVIQLKSSDKEDAEFVSYTVKRRIANEKIKHAMEKAKDVYNRMEEELIQAKKERTLARNNLVHAIYGVQVGELPKEENITHVLQNVSRSSIFNSQGGSKKVRYNEADPKDPTCGKTGDNGPGFTLINDFYCLCVGKENAKAVCNKAIAGPCCCCCEKCAKGCQCGKNCNCNPKCQGCENHNKWMYLFDVNKSEIVDVPEGWKRIRKICNETVKDEINTTAESIQEVLDDFNKLLGKNSSKKEIELKAANVESRRLFVLGYTNKMEGQGCTGKDSESSVCVNYWSVSNLGIGIVWQNYMLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD78</accession>
    <name>F9WD78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2333</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001835">
        <property type="protein sequence ID" value="CCD15229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57710"/>
    <dbReference type="OrthoDB" id="1675025at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394687" evidence="1">
        <location>
            <begin position="19"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25679" checksum="68B5E0DA66B1C42C" modified="2011-10-19" version="1" fragment="single">MMMKILIVVMVIIGVVRADEVGAAVTLTNHNELSHRALCDFLKVAVDKWKDVKTRDPADPLKKALKDTIFGYGSGDDDVEALKSKLPRDYDEVGSGLLSERSLWCGQQLDEDRVQQRRWPGHSGPHDLVCLCTAGENGWPVNSTSDTGSTLCGHNKDALEAGEKWWSGTNNTQKKDAIQKTWDVTVNQCLSGYSQETDLAAALQKFKDKIKKTTFEHETRYILGEGGPGWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA4</accession>
    <name>F9WDA4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_05970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001844">
        <property type="protein sequence ID" value="CCD15256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05970"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNase H type-1" evidence="4">
        <location>
            <begin position="200"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="676" mass="76399" checksum="D0BF478265E88A9C" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDC3</accession>
    <name>F9WDC3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 235</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_05990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001855">
        <property type="protein sequence ID" value="CCD15276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05990"/>
    <dbReference type="OrthoDB" id="278674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="3">
        <location>
            <begin position="305"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="495" mass="54758" checksum="55015B86DF433C45" modified="2011-10-19" version="1">MHIRRLTFTPCIGTVAQHLVYALCGSHASFQTHLKAHGSSRKRHRYHRRDFPDTLTNGGAEIGATPQRGTEGAGATAPPPVFTVVPTAHINMRMESQVESYLRGQEKQREAESQHRVSMTVPKINVINVPRSPLKRAVLDFDVRGQQVRAVGQSKRVKVARALCCMHAVQLIDHFSVDAAGRDDAPPPLEEEVISAGPYGLPSMHSSKHLRRPSTPSYPTWEPGAPWENYVGACEKYIRHQQQQQRAEAYAQLRIPPSGNPLVDRAADLTQQQRQCDNLALQKLNNEILHATKDMQVVRISRRIFAATLLLDGASHLCATGVASTLREAKQRCAMHALSILKLVREQRLQSGAADDAALPSNTSSHGGVSLSLSPRYAKLLDFFTLLCDVRPKPSFTKEGKKYTCELRLDGTTCKGSGINRFEAERNAVEGALSEMELYDERLQAINSIISRYPKIVPQCVPTVKLPEDLGEAYTHLCGAFAGTTPVWQTVPARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDE8</accession>
    <name>F9WDE8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58320"/>
    <dbReference type="OrthoDB" id="1667526at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="415" mass="47015" checksum="71B1437902235FDE" modified="2011-10-19" version="1">MVVCLFLCEVMCFSSFSIFLIIVGILDTRMMVRAMWAMGFAMVMFMDDVRVYSYPDGTVFNDVEYKALCEVFKASADLWDASKSAGKVPSNVLKSALSQALFGSTGGGDLESLKDELPKEYLDPGQRKYRCGYCDYKTDTYAGKSITHDLMCLCTPGKDAEPFYGYYWWLFGYYYKENGFKLCGTLKEEMGVDRSHGWYEEQKKRGTKGLEKAWKTVIMGCLKKWKNSSKTVSQDVTEKVKKLSMAMQNFTKALRRVNGLDKLGGFDEHNEADGTTERNLHVRYGNCEKKRKPWWKRLNETLNGKTPEDVLVDPSVSAQPTGAIDEPEEDGEFLEESHGESFESESPATQTSDSLQKNNGNSTHIPTTNSSNNRTMDTFNKTDSRNSTFPRIEYLRSNTPKTPPCSWLIGAPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDH6</accession>
    <name>F9WDH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2365</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001870">
        <property type="protein sequence ID" value="CCD15329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58590"/>
    <dbReference type="OMA" id="KWSQVLW"/>
    <dbReference type="OrthoDB" id="494374at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="580" mass="67002" checksum="BA5FD49E34912548" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM4</accession>
    <name>F9WEM4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002034">
        <property type="protein sequence ID" value="CCD15735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07470"/>
    <dbReference type="OrthoDB" id="1665657at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394952" evidence="2">
        <location>
            <begin position="27"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="44260" checksum="D0B4429B7A1C1688" modified="2011-10-19" version="1">MESRRIGRGILAIVVFMAMVMNGVRGGDFGNYGRGYDFNGAEHNALCGVFRAAVDLWNASRKSDLKLGGGLETSLGQAIFGNTRSKKLETITDALPKEYKNHKISQRGVLCGTCKYGEQPHYPGRSITHDLMCLCTSGKYGEPFYSYFWNYFFFRYSFSTTSYTLCGKKREQLVKDENEGWYEEGRHKQATGLDKSWKNVVWGCLSSSKREEGIESHDLKEKVSRLMETMRNFTTVLKVVDGRHRLGGVHGHNSKGDGKDEKSMHVHYDTCDIIRKPWWKRLNETLNGKDPEALLVDRSTPTPSVEGMEDTDGESEFFGEEQNTESEGPTPLAGSPLQSNNGTQIQGPTNSTESTVIPLNTSASGNSTYPRLEYLRSHAVKNLPCSWFLGASFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF01</accession>
    <name>F9WF01_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase B-like</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_08610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01002085">
        <property type="protein sequence ID" value="CCD15867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08610"/>
    <dbReference type="OMA" id="KIASYAM"/>
    <dbReference type="OrthoDB" id="724258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PTHR12370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="288" mass="31973" checksum="9926929CFDC4CD74" modified="2011-10-19" version="1">MLKNMTRDTFWVVEQLPGKAAPLGITAKDMTSVLNTSGYWASYNRPYFPNVYNLSGIHDMWKKYGDFYSYKNYSRARIFARDEGKVEDLASMKRLMRYNNYTKDPFSLIPNCSRTNSSFDDEETAPSVCKPPYSAMLSIAARGDLNPTGNDTFYGPLYRSVGHVDSAATDAKIATWSGMMKGNGTYTAHVICGPTTDGLPPFSWKNDIFDPMPPTFGLPKVYNFSFVVMTTVLPSPSKGSLWSRTGIIAIVAALVVGTIAVVLMRPRKDSEEDDALPEETEGLVDPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF51</accession>
    <name>F9WF51_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 350</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_09110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002104">
        <property type="protein sequence ID" value="CCD15919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09110"/>
    <dbReference type="OMA" id="VTSFMYH"/>
    <dbReference type="OrthoDB" id="1096393at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD15919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="218" mass="25020" checksum="77C295E895FE3379" modified="2011-10-19" version="1">MAGHNKADDTRMYTSWIICIISVLSHTTFLPTIYSFFRRRYAFELVLGVFGFAASLLYHICQTLDIEILMNNFAWHRVDNILAISSMGTWGVYMCTFRDPFVERITKYSLLMVCMIFQARGPWQPINGIIPGAISFSVPIGVYAYRWQVPAFFGKRLAAFAVTMVIAVWFFIKGLDDKRDPFKIYHSMWHFLCGIASYMMWTMVRVPGATGLLGKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF64</accession>
    <name>F9WF64_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002109">
        <property type="protein sequence ID" value="CCD15932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16478" checksum="6683821240B32ABA" modified="2011-10-19" version="1">MQGDPLSAVGRIKTHKAQNEELRKAAREFQSLSGSLDPAKSDKSVMDGVARRLQSIIDGQFGGENSNAEAPRIVEDLIRVKERLQLFGCKLRYGNRGNNTESQPATTEGIPTPQGNDGQSKHARVFFTLSPFFFSWRCKPQTQITKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL3</accession>
    <name>F9WFL3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 398</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002157">
        <property type="protein sequence ID" value="CCD16089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10520"/>
    <dbReference type="OrthoDB" id="1722781at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="19143" checksum="DE28CE1EDD42172D" modified="2011-10-19" version="1">MALYHIMALHHNIALYHIIALYHTIAVYHTIAVYHTMALYHLFGQYHSIALYHLFGQYHSIALYHLSGQYHPMALYHLFGQYHSIALYHSIAIYHLFGQYHPMALYHLFGQYHSIALYHSIAIYHLFGQYHPMALYHLFGQYHPMALYHLFGQYHSIALYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN0</accession>
    <name>F9WFN0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 406</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002166">
        <property type="protein sequence ID" value="CCD16106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10630"/>
    <dbReference type="OrthoDB" id="1713238at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22145" checksum="E8F3859BD8D6C7F0" modified="2011-10-19" version="1">MGGPGGLMGVPRGTTPLKSSHGNVKGGSHYQITWNATQLTVGVPHLIPTTRSVATGRHAELSATAIWCCVTSGVTAALPAAGTFSIRCDKCQTNFINSCGSPHTHHRYQHSRHSETTPPSQTRGLPVPHFPHAFSRPPTEPRVEERRWRSESNSSALPVCMGRSSENKPVQSGCSNIIKRENTCNPISSSQIWNRNKPHRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFW4</accession>
    <name>F9WFW4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 428</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002190">
        <property type="protein sequence ID" value="CCD16194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11430"/>
    <dbReference type="OrthoDB" id="1717461at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18661" checksum="4F136E4B34D92FE5" modified="2011-10-19" version="1">MSVQSGNKASDKSTHQVTSTPSTRRQPGGTEDSEMREVVWKTFKSWEEACLVDFLTQECVKTHGACNPNVTLAAFLEDPSHYIEEDERRKEAVEKLSEKLHHLKGCIFRDVPFLRAVGITTREQWAYRRFYHKMHTPITNYILLRACDPLLSTEELIKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG33</accession>
    <name>F9WG33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002226">
        <property type="protein sequence ID" value="CCD16263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14202" checksum="06DC6F6620A96828" modified="2011-10-19" version="1">MCPYGALQRLLPCIREETRQLWGKKRFQTPEAMTLCAFNILFHTQQVKQKGGSHMVEHSWRPSELPDTDGESISLASSKVRSCSTAWGISRDLRRIERNQHPAEALGNGVTVTQAPTHDPYIAALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGP5</accession>
    <name>F9WGP5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15560" checksum="F9AAAAE11099292C" modified="2011-10-19" version="1">MHKTMKMAVTTQMKKKMDFFFLKGKKGTENKDTCRYNHKTDRKEHPLQQLQVQKDAHNQALVSCNTHAVRILVVIARPSIPLLSLLLRQTGSLRQRKMWEAADTPPLPDHVCTRALRDNKTNQFLNFLLILLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS7</accession>
    <name>F9WGS7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 541</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_14320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002316">
        <property type="protein sequence ID" value="CCD16514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14320"/>
    <dbReference type="OrthoDB" id="1027397at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048208">
        <property type="term" value="P:COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="ACE1_Sec16_Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024880">
        <property type="entry name" value="Sec16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="PTHR13402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="Sec16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16_C" evidence="6">
        <location>
            <begin position="797"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1085"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1320"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1087"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1239"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1353" mass="141793" checksum="0A8D1E9824F89868" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGU9</accession>
    <name>F9WGU9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002330">
        <property type="protein sequence ID" value="CCD16537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01680"/>
    <dbReference type="OrthoDB" id="248987at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="264" mass="27387" checksum="C841FC67C2C5B9BF" modified="2011-10-19" version="1" fragment="single">MSDDSTPGTPRTPTQLEYGSTPPDFSVSCDIGVSDTRLASSGRCCVDPARAAAIERFLLGGHTGAQHPFGGGLATSVASTLAPGGECIRGPKSAVDNMSFTSKTQESAAVNPSKAIEKEKTTNLPLVEKVGGDSVELPRGREVVKSVDKPDTAVKQMKEAKGLRPDTSSRGLSSASRGGARLVISSPDQSDGVGLEDSPPSLHPGRPASVQPRRTRTPKSRSVGWSGGAARKIEEPLSGARKLKRTQSLGDISQLRCRSKGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGY0</accession>
    <name>F9WGY0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 569</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002347">
        <property type="protein sequence ID" value="CCD16568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14820"/>
    <dbReference type="OMA" id="ESSHSAY"/>
    <dbReference type="OrthoDB" id="1854029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19343" checksum="1F28E2D474FCBF0B" modified="2011-10-19" version="1">MKRGGPTFVFRRRGGKRLLGGPPQGDPRRPIEMRTNQARGDCRLSVQHSRGLKRSRREERDDRQRHRQRSSSRDRRRRRPRSRSRSRSRRSESRTARRNRRSHSRSRSRSPPSSRSSYSRQSSVASVGSRGRDRRRRGRSRSRSRSGSGSSASRSSTGSYRKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGZ7</accession>
    <name>F9WGZ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_14960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002357">
        <property type="protein sequence ID" value="CCD16586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14960"/>
    <dbReference type="OrthoDB" id="1666979at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="52"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="425" mass="46596" checksum="72AD30FDF45BE02C" modified="2011-10-19" version="1">MERRYIYIYLLLSFSTFQYKTFRSSKEIKKRLLVVMVMELRSKWLWLVGVFMTWSPVLGTGTTPKAIPTKAGAAICTLSKTLKDVTPWATQQVEKGAAKIGHLEMKLLEWQSKFIQYKSKGSGSEECKITGLLFRQVRKELDKARKEVEKLEREASKAAAFAANSAGRLEEFITVFANARNESGTGFCLGKEKAATPEELNDCFGGKVFSEDSLVDIGERVSEQEPNLDRTIEGIKHSVLSSHFNGVSSTAGCNLIKGEKGGILKSKSLEKSLWWGGGILSIGATYGGTGTFVPGEIVNATGNKATWTADPAQQIVHLKNASDTFKAFKAVQEAIQDKVKSIEDKIQSCLGGSESDENNTEQNVTGPDIPIPTSPTCFDNVAKIAAELKEKRALLARYQKVKGWIPPSSASHPTTQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH33</accession>
    <name>F9WH33_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 587</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002367">
        <property type="protein sequence ID" value="CCD16622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15310"/>
    <dbReference type="OMA" id="WRKPLRY"/>
    <dbReference type="OrthoDB" id="495562at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="556" mass="64865" checksum="D43DC8C666A78A15" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH38</accession>
    <name>F9WH38_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 589</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002369">
        <property type="protein sequence ID" value="CCD16627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15360"/>
    <dbReference type="OrthoDB" id="1719821at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19507" checksum="C775E2710E46CE1D" modified="2011-10-19" version="1">MGIKRNKLREGGEQEGLGQLCRVGDVDALSGATSHSATAFRFLDSCTSWCRCSAIIIALPLFFLFRRYLNSLGWWSRVYFSSISGFFVPSPRTPFGFQLLFILCWLIVLYFRRRSFHHISHMAYLFHLLFHSTWRFRGNVVEVRHLVPLPTCPLPYLFIFIPFQCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH58</accession>
    <name>F9WH58_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 597</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_15550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002378">
        <property type="protein sequence ID" value="CCD16647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15550"/>
    <dbReference type="OMA" id="QMNPFFA"/>
    <dbReference type="OrthoDB" id="687505at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="PTHR43888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390380" evidence="6">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="152"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="152"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="42905" checksum="775CEDC918CE2C01" modified="2011-10-19" version="1">MWVVRDPVTLSAWIFISVTLAITVVGGDEEEDFYEILGLEKEREDASERDIKSSWRKLSKKHHPDLAGESQRVRYQRIQRAYEVLGDRRKRKIYDILGVEGLKKYERPDEGQRMNQGIFSTFFSFVGGSGGNDRGEDEEVTLLVPLEDMYNGAAHTVRMPRMKICRKCRGTGAKSKEDYQQCPYCRGSGRMVRRVQIVPGFVQQVEHVCDHCEGRGRVIKKVCPVCGGHRVVQGTSSISIDIEQGTPDKHKLTYELEADQKPNQVPGDIVFTITTLPHPRFVRVSSGKPDKPDGLATTVELTLREALLGFNKTLEHLDGRVLSLTETGITKHGAVRRYAGEGMPRHHVPSERGSLRVVYEVHLPTSLTEEQRRVIEQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHA6</accession>
    <name>F9WHA6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 621</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_16020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002405">
        <property type="protein sequence ID" value="CCD16696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16020"/>
    <dbReference type="OMA" id="LIPNMQD"/>
    <dbReference type="OrthoDB" id="951213at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="PTHR11259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="391" mass="44922" checksum="47771935DF244797" modified="2011-10-19" version="1">MFLRTLLPFQCLPQPFLKVSHTFFAFPLPRCFSQPAMHDQIQKLLLMGPAGAGKTCMRSIIFDNYLPRDTLRLGITISHEQSRVRMLNNLYLNLWDCGGQHRYVAEYLNRQRDCIFRSVGVFLFVFDINSMSRENSDACEENCTEWSRPDMLEYFQAAMQCIRTYSPQAKVFVLLHKMDLIQQRLRSSIFQSRKEEILKRVVSGDEPAADIQFFATSIYDDTLYLAYSNIVRSLIPHGYVLKREMEKLLVSCNAAEVALYERSTFLCLTHVSRISNLDDNDEGLSGVDDDNDVAPILSCSECRTTKVSETVKHFKLSCMNNATSLEGYQITTDTFTALLHPFTSCTYVLIFSEDTSISVELHRVNVCSARHEFEQFLLSGDRTAEEMRKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHC6</accession>
    <name>F9WHC6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 626</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_16240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16240"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="106"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="263" mass="28329" checksum="CFB49B1E42744F4B" modified="2011-10-19" version="1" fragment="single">MLIKLIREVKNRGLFVNVLLATVVICSWCGYAVGQPGAEVKATDNAEQFALLCRIYNVAKNPPIHHVDLQDPLKIVKEIDVINASLVNPKWLNETDQVESSSGALQPTTTREAAVAQALIRRISQKAHNILDDIRRLNTTSAIENVKAVFAQVIFGGGGNESDLDKSTLSEVKGRADACGKSGLQSKGQSAGKNLVVDFFCLCAQNSDKNNGIENVCGVKVGSKDDNHSWGANTVLGSPSLWASIKKGCGNLFHRYPNSTKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHF5</accession>
    <name>F9WHF5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 640</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_16510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002426">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="558573at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING-CH"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RINGv"/>
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    </dbReference>
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    </dbReference>
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            <end position="343"/>
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            <begin position="355"/>
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            <end position="835"/>
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    <sequence length="835" mass="92891" checksum="02FB83D3B6F7E7EC" modified="2011-10-19" version="1"> </sequence>
</entry>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
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                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
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                <person name="McQuillan J."/>
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                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
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    </organism>
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        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
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                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
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                <person name="Sanders M.J."/>
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                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="336" mass="35495" checksum="BC4407FA23880F1A" modified="2011-10-19" version="1">MNDFPFRWMNSYPKFGGLYPASRRNHQESRRTWFDAPETAGSSIEESLHDERYLALFVILCQLQHETPVAPPSPPSGPEGSETASEELNGTNTNETASEELNGTNANETTSEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNVNETASEELNGTNVNETESDDSSSGVSSTEAPAGKVNGGVLALAILLPIIAIALLLLLWYFCFRRRDEKEDAPLSLREVYSPAECPSPVEAPLTSEGGGAAEGGSPNASPVVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHH1</accession>
    <name>F9WHH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 647</fullName>
        </submittedName>
    </protein>
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        <dbReference type="NCBI Taxonomy" id="1068625"/>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002434">
        <property type="protein sequence ID" value="CCD16764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16650"/>
    <dbReference type="OMA" id="PESYRIW"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="324" mass="34767" checksum="AD567145F4646AE5" modified="2011-10-19" version="1">MNDFPSRWLDAYPKFGFLYPISRRYSPESYRIWFDEPADTHSKDAYIVRPERPVGFYAALCNIYVPTTSAPVPQPESSETASEELNGTNVNETGSEELNGTNANETGSEELNGTNANETASEELNGTNANETESEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNVNETASEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTNANETESEELNGTNANETASEELNGTNANETASEELNGTNANETASEELNGTHAHETAREELHGTNANETASEEPNGTNAKKQGGRAHWYQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI2</accession>
    <name>F9WHI2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002438">
        <property type="protein sequence ID" value="CCD16775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16760"/>
    <dbReference type="OrthoDB" id="1672171at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="304" mass="34963" checksum="7BAFC2C6A77F5AAA" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFIRVIFSFPSPGALQNCFCNNYFMLFRVIFSFPSPGALQNCFCNNYFMFSVSFLVFHHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCYSVSFLVFRHPARCKTVFATIISCFRVIFSFPSPGALQNCFCNNYFMFVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMCIFSFPSPGALQNCFCNNYFMLFRVIFSFPSPGALQNCFCNNYFVSFLVFRHPARCKTVFATIISCYSVSFLVFRHPARCKTVFATIISCHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS9</accession>
    <name>F9WHS9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 693</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002484">
        <property type="protein sequence ID" value="CCD16874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17580"/>
    <dbReference type="OMA" id="YASGWHE"/>
    <dbReference type="OrthoDB" id="551955at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="PTHR44163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="804" mass="88401" checksum="18AB56C960D66E4F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI44</accession>
    <name>F9WI44_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 730</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002526">
        <property type="protein sequence ID" value="CCD16989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18580"/>
    <dbReference type="OrthoDB" id="1713736at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="22970" checksum="8299940B7B46ADF5" modified="2011-10-19" version="1">MCMCKRCFSSAPLPLLSVRCISSITALHNRPTFFLKKKKNILTWSCERMRRFPSISLLYTPPRGANWHLSMWGSFSFFLFSPWTHQCYARLPCSSSWGRGEKGIEKIGDVCLRVYRYSNRGLYFPFSPSVPLPITMLMLFSFFLLFLLGLLPHFFFFACFFFFFFSILMILLYLMGRIDCFWWSFRCLMRCAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI59</accession>
    <name>F9WI59_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002531">
        <property type="protein sequence ID" value="CCD17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="13248" checksum="0F17C410B4CEC345" modified="2011-10-19" version="1">MTVASHAHIGHCSVKESGQSFNTLTITGACNPRGVTPFRHANTKNSDSATSPALATWAGLAMNPAVMRGGGSGMSSLQSTAECVCEGGLGNNSTGERNSACNIPERNPSHLHRSQASAADHRALTMSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI63</accession>
    <name>F9WI63_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hexosyltransferase</fullName>
            <ecNumber evidence="7">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_02050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CAEQ01002531">
        <property type="protein sequence ID" value="CCD17008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02050"/>
    <dbReference type="OMA" id="HMGLAIF"/>
    <dbReference type="OrthoDB" id="1037602at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="PTHR11214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="42537" checksum="EAAFAEA021BBE957" modified="2011-10-19" version="1">MYLVHDTLMEPLRWAMLLVSIASCYIAITLFLIGPSGVVTRAPPAELTRNYPGWMREALAFTPAAAIRKWQHIDYLLVLGIPSVDMLERQRRRNLQRTTCWQYDGVARRANGFTGAMLPLYVLARHPSNGYAYTDAMRREALRWSDMIALPMYEGKPSTNKKVGGGGKWGTEAEIGMSRKTFYWFDFALRMFPNASYFAKGDDDMFLRVPQYLADLRSLPRRGLYWGTMGHFAVDGYGFTYAFGALYTLGRDVAERFFSYLPLKSVIDLPYSEKEAHKFKALYLYAEDAMVGITLKRAGYSSELFHVNEKKCSFHDIHAGALVGPVSPSSVMVHHVKEEDYGALMKRFNDGKVVAPRHFVYSTKMVVSRSLKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF4</accession>
    <name>F9WIF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 782</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002583">
        <property type="protein sequence ID" value="CCD17101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19530"/>
    <dbReference type="OMA" id="KYIMEER"/>
    <dbReference type="OrthoDB" id="1387490at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="331" mass="37044" checksum="C9DDC61F9E95721A" modified="2011-10-19" version="1" fragment="single">MSCGSAAGMYDQTRHTVAMLPPLRTVGTVMSEPPKPARRLLHIPEKQLCWSHVCGRKATLGISSSGIAATTPQVGNISTKGFDVNISQHYCSYDTASEVANDLYLFELRAERSRYETSNLLASQHGASAHSRASTPLECHSQGSSEGAPRLRRDTVSSLLPCLSSDMFLQRNNIAEQLRNMDKTYVVQKVRAEGRRLGMREVSLQEFTYLLSCLLDEETLDKNEVRYLFRFLYWNTQETISFEDLIASMSLLFARVEILILVQCKYIMEERPLDNSVIALVDLDAMLASIKAVFTERVPEVCQLCDHVRCALESFAPCYAVPAAAFRVVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIG1</accession>
    <name>F9WIG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002585">
        <property type="protein sequence ID" value="CCD17108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19600"/>
    <dbReference type="OrthoDB" id="1670509at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390428" evidence="5">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="58"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="263"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37670" checksum="27797CCA2031E324" modified="2011-10-19" version="1">MMRITLLVMMLGFGMSVITPSRGTDHNREAYQALCDVLQAAVKTWGHHGEGLSPPLRRTLKETLFGYGSPGGSVEDLRKTWPTDYNDTGGFRDYYCGRPRSSVFPRWPGYSAPHDLLCLCVPGEKGYPVNNTHPGHTLCGKTRDALGGGTHGWASSAQGANPQEGHASITATWWNVTVPCLQPPRKDTPLEAALTHFIRHLAPKSGDTNYPHRKQLGEGTPSTYDGCTGVYSPGICVMYYPGDRSPRNPSLPQPWWITLEQALRDDDPQDPERRVPDARINHSEKSETAALLPPSPTETSPEKQSARLAKKHHHHPHHRPHSGAHLLWPFSGVLGTVVLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIJ9</accession>
    <name>F9WIJ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein TCIL3000_9_5060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_19940</name>
        <name evidence="4" type="ORF">TCIL3000_9_5060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575322">
        <property type="protein sequence ID" value="CCC93100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002608">
        <property type="protein sequence ID" value="CCD17147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_9_5060"/>
    <dbReference type="OMA" id="RKKFHGV"/>
    <dbReference type="OrthoDB" id="1547011at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_L31e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_L31e_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="PTHR10956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="SSF54575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC93100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD17147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="188" mass="21763" checksum="40CB2148101C082A" modified="2011-10-19" version="1">MTRSGFKGKVLGKERKLALLEARKKAIASRKSRDDRHWKRVLAKMDPEKRKKYHGVGNTAEHSRVRGVTRASLRKRTGRRPDNIVMEATVHLSKLLKKRTFHKRAPIAIKRIRSFVGKLMKSKDNRIDASLNTFIWHRGVKGVPGRVRIRVERKSETTEGGKRKHFYTVISHIPVPTFKNLTTKVIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIP6</accession>
    <name>F9WIP6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 817</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002622">
        <property type="protein sequence ID" value="CCD17194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20310"/>
    <dbReference type="OrthoDB" id="1707779at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390443" evidence="1">
        <location>
            <begin position="18"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="215" mass="24898" checksum="8146A59A56849468" modified="2011-10-19" version="1">MCVLLLFFLFFVTPYLIIRIRREKEKGETGHRGKYHRKGDENIHEIWYLHYPPLGTHDFFLTLPIDLLSIRHSLFSLSFRVTCFSFLHFYPFHCSCTRERVNESNVYGVLFCFVVVCFVDAHVSASSTISDSFSTSFLTCVNEICSLDFSLYYCHVNAQKTHKTDKKGCVHGGSHITTIEKVTPIRYRQLQHTEARCGKTKEISIAILSLHVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ6</accession>
    <name>F9WIQ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 822</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_20410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002627">
        <property type="protein sequence ID" value="CCD17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20410"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="461" mass="52874" checksum="425CD4CD8F0727D2" modified="2011-10-19" version="1">MSVDAKIKGRAGVKLSQPKAVADGWEEEMKKEEKIGRLHRDGALDLSWIWETYDAFVEIAEKVKELLKNPEGKAGKGDLKELEKKLKDGQEKWPEYYEMKKNYWRRRLEVVEQGGETDAVEKDLKVQEEEADRLEKELETIEEALAEILAEKTAPKTDAEPDPVLRELTCDVCGKKYVSFKWLKKHVEGQHPGKKESVSDIMKRGLRCPHCEKEYKTLGWLRRHIRAKHRQQMDELADGKAFSCLLCEKKYASAEWLKQHVRDGHSNQSEPDDDEDSASFECSHCGKTYKTQGWLSRHLREKHPERHQMEEGAEGTEGISGVAESTVDPGASAKEALSGTNETSVERVPDGRLICPYCDRKCASVGWLKRHVKEEHPDQSVSDIDEESLSFKCKHCDKTCKTRGGYERYLQDKHPGKTDSRDLTCDSNEDSGLLPCPYCDKTYKRIGWLMRHLREKHAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIW8</accession>
    <name>F9WIW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 841</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002649">
        <property type="protein sequence ID" value="CCD17267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="167285at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="284" mass="29315" checksum="9A4C2356D3A2D0A3" modified="2011-10-19" version="1" fragment="single">MDPLNAVAFLTSGCSQRCASPIVIHGGVIAYSSADAVYLYSPVVHKASVATSRRQSQLHGATPNQAHAAGASTEKKSTTYPLTRVFSNGVNGTIVSFHLNDDYVVCATSNGRGIVWRMVDGEILSGKAVLDSVSDFFRREGHPCSVLVSGKYHILFGTSRGCVVSANMNDGVTMHNVRLSADGATDRSESAVGRVCCMVTSSTRPDIIAVGTSGGFVCLLSLHPANGMKQNAVVKAFAMAAPAPSDKGNPFGSSASTVTGVSGGTHGGEGGKETHLPAVSAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY2</accession>
    <name>F9WIY2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase</fullName>
            <ecNumber evidence="6">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_02350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="6"/>
    <dbReference type="EMBL" id="CAEQ01002654">
        <property type="protein sequence ID" value="CCD17281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02350"/>
    <dbReference type="OMA" id="QTSENME"/>
    <dbReference type="OrthoDB" id="293315at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="8">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="7">
        <location>
            <begin position="179"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD17281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="843" mass="95926" checksum="89795EA8B3EDEB3E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ25</accession>
    <name>F9WJ25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 863</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002673">
        <property type="protein sequence ID" value="CCD17326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21540"/>
    <dbReference type="OMA" id="IVHECNR"/>
    <dbReference type="OrthoDB" id="1247045at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="613" mass="68832" checksum="942AE5667E6670F4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJN0</accession>
    <name>F9WJN0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_23520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002747">
        <property type="protein sequence ID" value="CCD17537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12098" checksum="4BB94FC486EAB330" modified="2011-10-19" version="1">MATSTEASFERTTIGERITAWPRVLPAPDGAPSHQAPGQLVGNSADLACGSPKAPRPVHRWREKQLFSRTRGTSSSKVPLWNGEGAPHDGHGGRLRKSRSESTGSLETVSEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJP2</accession>
    <name>F9WJP2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 934</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002751">
        <property type="protein sequence ID" value="CCD17549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23630"/>
    <dbReference type="OMA" id="RMMDCGP"/>
    <dbReference type="OrthoDB" id="833985at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="373" mass="40553" checksum="89379C4CF1F59C5C" modified="2011-10-19" version="1">MDDNLLLNLIRLVRNGRLLVRGCEVFNFGGLRMMDCGPYIEDYARLKNSADCDSSLQAFLSVYIRDVVVEVWHFEDFRTMMYTPSSQDYNRQCSPANGKSEAALSTLARVIFAYLRVHELYADIIQARATDVSVKVFTDPCEVPTLEPDMSSTKVWAIEGLVSIKVTYNRLWHRLLSPKLLPPLVSVLTYCDSSLNELPRTKQTAPIEMVNALDSRCGAVITVGSDSAGSGCSMPTPLFAPVPLPGSLGSGRFGHTYNAMRSPILGALDTFIMPPSVTTANNTSFIVPLSQGAAGAAILSGEVVTPAVPDHSFSAIPTFMDISGFSWSEECGNDSCCASDQLVELLEICDNVSLSEQPISITAVVENLGKPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ7</accession>
    <name>F9WJQ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_23760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002754">
        <property type="protein sequence ID" value="CCD17565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23760"/>
    <dbReference type="OMA" id="QPRTKMQ"/>
    <dbReference type="OrthoDB" id="199733at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="SSF90229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="827"/>
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            <begin position="1"/>
            <end position="95"/>
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            <begin position="207"/>
            <end position="243"/>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="GO" id="GO:0008237">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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            <end position="295"/>
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        </source>
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            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
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            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK13</accession>
    <name>F9WK13_TRYCI</name>
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    <organism evidence="2 3">
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        <lineage>
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            <taxon>Kinetoplastea</taxon>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002798">
        <property type="protein sequence ID" value="CCD17674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02680"/>
    <dbReference type="OMA" id="ECDELFF"/>
    <dbReference type="OrthoDB" id="1268130at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="402" mass="43946" checksum="0014F55490FDD570" modified="2011-10-19" version="1">MQSTKAKVTKQEQHNVPVTLSTSSSASVYLTTITNRIAARHGVSFLILKPVEYTGQTKEPQESIKNSMKGAIAKGSTNNPQAMEKFKQSAEMWSAMWAQPSGSVGSQVQTQHRVRPILPASLLLLFSDMGMSKPYEPLGLLGLLKPEDEVVSRCFRGAEARQSPLQPVICIYLNALESIIEVTDRLSAQAKAMYCQIYRENALKRGTDVANHGGNSTKSADNSPEKCRSRFFLLTPSAPYAALRETANRIVNDEDTGLTGTSLGLGEACEILLVYDLNHSSHSFARDHSPECNPEVWGHVNYQQKRSGNSSGDAHERDELFFIAQTLEDYFRLGSTFSWVYGWQLCYASQGPPARSLSWLKLFSPNALAAVVTLNALGSGSKSTAADKTSAITPDADTRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK60</accession>
    <name>F9WK60_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA_pol_L_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_25050</name>
        <name evidence="5" type="ORF">TCIL3000_11_9200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002814">
        <property type="protein sequence ID" value="CCD17721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="AICHFRI"/>
    <dbReference type="OrthoDB" id="1398114at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_L_2" evidence="4">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCC95462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD17721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14729" checksum="043C3E1D68F1FED6" modified="2011-10-19" version="1">MNVYPRDAFISHQEYIQRMNAGDEVDTSAEQKVEVNIHRLTGADSAATVTFSHEDHTLGNPLRYVLMQDPDVTSAGYAIPHPLEAKMQLHVQSNVYVVDAVVKGLERLAEICEVTLRNFEDCMRASIERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK66</accession>
    <name>F9WK66_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 993</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002817">
        <property type="protein sequence ID" value="CCD17727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25110"/>
    <dbReference type="OrthoDB" id="1662327at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="507" mass="54659" checksum="37D758F5E6C1A52C" modified="2011-10-19" version="1">MTLSEVISGFVKMTLSAVISGFVKITLSDVISGFVKMALSDVIPGFVKITLSEVISGFVKTTLSDVIPGFVKITLSEVISGFVKTTLCEVIPGFVKITLSDVISGFVKMTLSDVIPGFVKITLSEVIPGFGKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLVEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLFEVISGFVKITLFEVISGFVKMTLSEVISGFVKMTLSEVISGFGEMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVRMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLSEVISGFVKMTLFEVISGFVKMTLSEVISGFVEITLSEVISGFVKMTLSEVISGFVKITLFEVISGFVKMTLFEVISGFVKITLFEVISGFVLNTPREDLSGFILTTPEKASPRVILTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK83</accession>
    <name>F9WK83_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_25280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002823">
        <property type="protein sequence ID" value="CCD17745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25280"/>
    <dbReference type="OMA" id="DRSICKY"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390457" evidence="5">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="79"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="405" mass="46516" checksum="63E3404BB65F8301" modified="2011-10-19" version="1">MLQRGVTLLLFLFSWSMSSTCEEKHKQNAGEAELFCRIRLLAENDPEKLVFENEEREKHIMRQSEKIGPEIRSLVGKSEQRDATLITQFNDLVKEAKKIIENMRDLRRKAAEKRLSAKRHLHQVIFGEYGGEGKGELDTTKETIQKIFNNEKFEKSCGGQGDKPAGKSLINDFICLCASNTGFDAHFDSHKDRSICKYGVTTTVEANFKNWTEVWYWNKHRICINTAPPIPTPQNINYLVAHFTRFLEREQKDFQVKNVFGYVKTTDNPKSVCNTTNVGSICVNYIHALSHGGIEWVNHLKNASQDLKDMVRYAEESESSLPQLELLEYNALLLYEEAKYSTHLPHIVPSNETETNSSNEGYEESSPNSTNASQGGEFEEEEDADSTWKARPPWWGMPFFFLFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3B3</accession>
    <name>F9W3B3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1032</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_25910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000387">
        <property type="protein sequence ID" value="CCD11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25910"/>
    <dbReference type="OrthoDB" id="1783224at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19403" checksum="77434D2190526EE7" modified="2011-10-19" version="1">MHSPRSGFEYKDSLPQSPKLLPPVGGKLRCRKRRRKVGGESEGEESAMNYLRHLCSLLSFPLHLLRLTFAKEPFIALSKLSLKVLLWCDLAFVGDVSIRRESSAVAGLWMHFFLFKRAFPFPPLPIFLFISLFRRFLFCLSSLSVLPLLLLVPRKVLLSLALSWRTCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3J2</accession>
    <name>F9W3J2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1059</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000418">
        <property type="protein sequence ID" value="CCD11710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26640"/>
    <dbReference type="OMA" id="EKEMHRC"/>
    <dbReference type="OrthoDB" id="289074at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1275" mass="142468" checksum="4216C6F017A79956" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3N7</accession>
    <name>F9W3N7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconolactonase</fullName>
            <shortName evidence="2">6PGL</shortName>
            <ecNumber evidence="2">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_27080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01000444">
        <property type="protein sequence ID" value="CCD11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27080"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="1420529at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="3">
        <location>
            <begin position="12"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="266" mass="28622" checksum="CCC4FF85B42BDEB0" modified="2011-10-19" version="1">MPFKPTIDVYATPHELSAAGCRKIVDIIEAHEGEKWPLSIALAGGSTPKLTYARLRSEHLPLLREKRALRFFFGDERMVPADSRDSNYNMARETLLVEIPDDLIVPVDTSGVTAPNEATPLDALRAAEAYEGKLASLLPSQAVGEEEVRVPVFDIVLLGLGSDGHTASIFPGSPAAVEIGGQKAVSIGFPSESMSPKVWRVTLTPAAIMHARNVIILATGAEKKWVVEGILADVTSDAPVARFLRGCKGNVSFLLDREIAQSLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3P4</accession>
    <name>F9W3P4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000448">
        <property type="protein sequence ID" value="CCD11767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1786902at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="14254" checksum="4B7E337541993241" modified="2011-10-19" version="1">MPSHKKVKALPTLCVTPSQPCAYLVQPRAPVVRCARETPSHGGDEAAGGSNHPMASPPLVLHCPAPTWCGRGSGPFVVSLLRCSNPLGAAVFRAAACDTASHNSMRKPPWLPRSLHTIPARVGGRAPHRTALANST</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3R1</accession>
    <name>F9W3R1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000456">
        <property type="protein sequence ID" value="CCD11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16548" checksum="42679F2B9D3EAE9D" modified="2011-10-19" version="1">MQAARWRCKLFASECLSRVAVRNCLVVGWCCFGSPTDMPRHYNRQTTALKYHNSTKRRRERHEALRWNDSLEFVQWPSVEADVPEVERFQDYVAETCHPHLFFCLCGYWIGTIGGPSTTRKGLVACITFHTSLGIASVALARCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3S5</accession>
    <name>F9W3S5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000462">
        <property type="protein sequence ID" value="CCD11798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27420"/>
    <dbReference type="OrthoDB" id="1706169at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21633" checksum="8F802219462627D5" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQENTPWSMEKDVVDVLLDGVTSADHVNLYWFLRPVLACLPVDLVCFTLGDFVRNPRHCIPEVNVCDALWQYLPYLLWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPPPYQPYQEVVLVEAAPAFIQVPYSTVGYIVQIPLSPRPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-10-07" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3S8</accession>
    <name>F9W3S8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_27450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000463">
        <property type="protein sequence ID" value="CCD11801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389761" evidence="4">
        <location>
            <begin position="22"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD11801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="571" mass="65114" checksum="89D2142568B33BFB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U6</accession>
    <name>F9W3U6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_27640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000477">
        <property type="protein sequence ID" value="CCD11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27640"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="12"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="358" mass="39314" checksum="855743811F89A07B" modified="2011-10-19" version="1">MKKEDAGNNSEAQVKPTVTREAALAQLSLNQITQKAHTIWDEIKKMEITENIEKAKAEFAQVIFGDNGNESDLCNATVKGVGNRSKACGHTGLSSKGSSAGKNLVVDFFCLCVRRQDGEGVNQVCGFYAGSGYKNGQLGWNETGPWGSSTMWALIKGGCWKHMQQHPKSTSEARHILDKFLKHLKVGGVYRQIKCENDPPCSNRKAKTVVSGSDRKAGMLGTAITVSISTEVTCDGKKGDEKTGKNPGGVCVYYGQESEWKNIPWVIKFETALASVDAVNNQKTSIQRAIQKLQMLLHRAEEIYETTKVISEIKYHGGLTAALQNASGNLTVYNTTRIRSYSYNLNSYFVPAWALLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X1</accession>
    <name>F9W3X1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000489">
        <property type="protein sequence ID" value="CCD11849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="106" mass="12397" checksum="3F1EE47C45CCC9FA" modified="2011-10-19" version="1">MWKSTQTHHRYQHSRHSEATPPPQTRGLPVPHFPHAFSRPPTEPRVEERRWRSENNSSALPVGMGRSSENKPVQSGRSNIIKRENTCNPISSSQIWNRNKPRRRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y0</accession>
    <name>F9W3Y0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27980</name>
        <name evidence="1" type="ORF">TCIL3000_8_6860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000492">
        <property type="protein sequence ID" value="CCD11858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27980"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_6860"/>
    <dbReference type="OrthoDB" id="1699497at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCC92459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22664" checksum="110EE7DD083D4BB9" modified="2011-10-19" version="1">MLSLPREAPKVNSLESHFNSAVVKDVELFFADLCKGICLLPFGQWTPIAHKSLCTQWSGACSAFTKFQLAASVVSSLTLFPFIMLRDVSFSALLNMHISTTPLSYWFTFSNFLFQVFQFPCPERCQSISLLYQHPCRGANCRQNGAIQLASFLRKFSNHSFNFLTQVCRNIPSSRYSTQRVWGRVCDYAPHKRSCPRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G2</accession>
    <name>F9W4G2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, PAG-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_03060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000550">
        <property type="protein sequence ID" value="CCD12053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03060"/>
    <dbReference type="OrthoDB" id="1674363at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394547" evidence="8">
        <location>
            <begin position="23"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="41"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="41717" checksum="977D178A7F383C09" modified="2011-10-19" version="1" fragment="single">MIHRNVLVFFLCLAVLLSVCHAAAGASTEEAKTFLRLSKARSICNASRTMKGVHSYVSRKITEYQKKYDEMDMIRDVARLKVLMKVNLDAKCGREATFLLYVQEGMIAFREALEKLRAAGVRAVASAGIAAGRLDEFMSVFKQAHGKNNDPRNCAGKIGSVVDGMKLMLKECYRGATIEDEFHSVADVEAEFGVKDLELEEALKKHLTANNEGTGASNDPTICNLGIIDNNTKTYVKDETPKEIKWGDGVLLLKDGSGGGDKYKWAESPTTAIPVIKSAISDFSDFKKAVTDVERCYAGLRDDWTDSRLKEADMQRILASLKYNKFNTSEAVSFHVLSSLQTDENNTNVLFPEWNREKVAGKIWKRNWLFVMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4W8</accession>
    <name>F9W4W8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_31190</name>
        <name evidence="3" type="ORF">TCIL3000_11_8030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000624">
        <property type="protein sequence ID" value="CCD12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="CLMESPV"/>
    <dbReference type="OrthoDB" id="1538795at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="PTHR20648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="SSF54695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC95356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15324" checksum="5DA007F2161C9A61" modified="2011-10-19" version="1">MLRGAPFNPMRQTPPPPPCIDTFTLVPSDYLSMYSADGHRFVLHRDCACTSPLIRKALTNMVDPEVHDIGFEWANGKGEPPVIYFHKASATLLDVIVRYLYYKHRYEGDMESRPPFDVPPSIALELMKIADVLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4Z9</accession>
    <name>F9W4Z9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_31470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000637">
        <property type="protein sequence ID" value="CCD12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31470"/>
    <dbReference type="OMA" id="CHDESIC"/>
    <dbReference type="OrthoDB" id="1114772at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="30161" checksum="12726727C5E29F0A" modified="2011-10-19" version="1">MSHYVLNRVRAKGRAVRSEAQAQDEGSRSTESAGDGDEDGGRPRKRSRMGRHTEGEEGRDYVCGRCGSAYKQWYSLVRHTPTSHDHATTVKRKMKDGTIAVTPLLQRSLQCPYCPMKCALKQYLTIHLQAKHGQRKKESEHNLLKAECEESAAHLLELPSLRGLRKKHGLETRKDGEVFFSAQLASFLKELFKLESPLSPPLDSPKLTPARAVKRHRSPTALDTAYPPSAATTLLEVSDARNLRKRPRAVDSLSTAACFKDFLDEARTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W517</accession>
    <name>F9W517_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1264</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_31640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000645">
        <property type="protein sequence ID" value="CCD12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31640"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="186" mass="21114" checksum="AA7CA58BC9D16F19" modified="2011-10-19" version="1">MYRSFEEGRMPLTHRRVLLDHIRPALKHTKPGRLCESLLAQLRTGTSKHFGWLHRVLTRKTDRLENRWCRAKDIGGDAVEEQTLAESAVDCANVQNFVIATRLSDPIICPLCNMVCARRQAGVVHLVKIHGLERDCALAMTKKARRAALTYKNGYTCHVCGDAFERRGLLVEHMTQHPPDGILDHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5A0</accession>
    <name>F9W5A0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1298</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_32340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000684">
        <property type="protein sequence ID" value="CCD12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="LRAYMST"/>
    <dbReference type="OrthoDB" id="1131114at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20441" checksum="6B866C4A372DDE9C" modified="2011-10-19" version="1" fragment="single">MGSLPAIDLRVETLRLAYGSLLRLFLYPLAYYTGRGLFSQYILRHKGSLTAWRRCIPPYVASQGLEIGVSLLICPVRYLAAVSTPRFMLDYMLTGWSEVLRSLDLFSPGKYVSYADYAFSSISEWNLDFFTWQVPAAVLTLAKVWYRRPPFXCAELPHCASAADASSSAFLTSLSLLLFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5C6</accession>
    <name>F9W5C6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000697">
        <property type="protein sequence ID" value="CCD12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32600"/>
    <dbReference type="OrthoDB" id="383645at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="25608" checksum="813470597816358C" modified="2011-10-19" version="1" fragment="single">MILLRSVMVSIAPLLDLSSFFSLLRFPKCIEIGWEMRRHSPLFTLASPPSVARLRLLTYPMALAQPDASVPLVRSGSHSALCGGGSHFQCGSDTASHLSTRVKPRGHAGVSAGSGEHSQSSAVVNPHRWLRNPDELCVASLHRSKDINEVNSYVATYKFDDPQWAPLLLPGVICRPRMGTCSSGQPRTGGKVDSAGEVGEATSASGSEPPPPTESSSSLLHGDYRVWIDHNKLINVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D5</accession>
    <name>F9W5D5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_32690</name>
        <name evidence="7" type="ORF">TCIL3000_11_9160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000702">
        <property type="protein sequence ID" value="CCD12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="FLMWLPT"/>
    <dbReference type="OrthoDB" id="1422977at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="PTHR13180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC95458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15677" checksum="EC731D2E5E8BC0A5" modified="2011-10-19" version="1">MRLLLQFAAGALFSVSLFVFADGLIMAKRTNLPYNFLMWLPLILMFCGMFILCYVDVRTISSRYELLDDSSAVRDKAFFFTSVLFMLSGFAVSLWKAIDPYANNGDLWPGASLVIQSILLMASSALIFFRNSWDDNALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5F7</accession>
    <name>F9W5F7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1322</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000710">
        <property type="protein sequence ID" value="CCD12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32890"/>
    <dbReference type="OrthoDB" id="392056at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44542" checksum="D1C7632A0DB273C3" modified="2011-10-19" version="1" fragment="single">MCSRSNNELQLLYQELTQSFSAYGGFLSPSQAPKRVEPLEKSSFDDTSNEGASYVHQQPIGSSCDRAGTKRELARQLSSKQNFQKHIGTAGGGCENEKTCGATTARTRDSSNGYFQRLPKSTFVNERLRSILHRHNKRWDCIDAENMSGGACGLNDDGKQLTTMDWSSHGSNIVEDMDEPIPASSSSAYPFACWLCGTPCAMRPGWVDGPIFFDGKRSSSQFSLAALCKEDVAPSPFISLLTLCGRCSMACSLPSLVAYEIVLQRAAATHVSAKRTPAFVSFLRGYKAFLESVSSSTRYNVDGHKYFNECSTVTQLNILQQLIGLLESYVIGVKRTIFSEGPQSEEQLSTLHPEERHILEGELGLLQRHVQLIKTKSLVRDKHLRSYQMDSNSVADESQFVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5P6</accession>
    <name>F9W5P6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dynein arm light chain, axonemal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_33740</name>
        <name evidence="3" type="ORF">TCIL3000_11_5800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000745">
        <property type="protein sequence ID" value="CCD12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.5800"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33740"/>
    <dbReference type="OMA" id="INCTERG"/>
    <dbReference type="OrthoDB" id="1375694at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019347">
        <property type="entry name" value="Axonemal_dynein_light_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13183">
        <property type="entry name" value="PTHR13183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10211">
        <property type="entry name" value="Ax_dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC95163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="237" mass="27404" checksum="F2F8CD8C579A4F89" modified="2011-10-19" version="1">MAARPLLVKYDTPMLLSEVKHRRALKEKKRGAIGVDNGPQAEDVLCSIIPPRGYEENGQQWVQYVSSTPATRMDVINLQERLDALLLERNARESGICPVREELYCQVFDEIIRQVTVNCAERGLLLLRVRDELRMTLDAYRSLYESSAAYGMRKALQAEQSKIELVAKIQTLEREKEELKRQVEELECRCDSIIQQEKERFAEAEKKHNEEVAFFRRTYQTLTTNLQTVCNPAKPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5X1</accession>
    <name>F9W5X1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1395</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000791">
        <property type="protein sequence ID" value="CCD12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1698541at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="29256" checksum="BB38ABF7FF44E3BB" modified="2011-10-19" version="1" fragment="single">MQENDRPLFKALAPDAVEQTGHGLAGIHRVQQQTFLAGQKFDRREGASVWLVIPRPEILVPQGDLEGVGDSHTEQLGSAFGQALHFRELRLLGARHRDADHWQLRQCFAQGQGQAAVGTRTARGEHHGGELNAAVFNLRGQLQPGAHVAQRAECIGTANRHQVRLLAVTAQAVGEGVELVVGVVEVFHQLHFGVEQLQQQAIAVAQVVGVVGAGRVFQQGNTAQAKPGGERGGLAHMVGLDRAGGDQGVGALGDGVGGQVFEFAQLVAAHGQRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W609</accession>
    <name>F9W609_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_34740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000807">
        <property type="protein sequence ID" value="CCD12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14819" checksum="5C7BBA46F5BAB60A" modified="2011-10-19" version="1">MIATLGNGSERCNGKGLQHSCGILRVAEWESRGESPMSSARARRLFANWEAVSVQQEVVRLAYTEREAEDFVTQLVTRTIAHGNAKRAMEREEIYVPIEEELLRATKWRVCAGEEQSHSLHLRRACGGDCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W655</accession>
    <name>F9W655_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000823">
        <property type="protein sequence ID" value="CCD12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15945" checksum="EF7FC400FE562C91" modified="2011-10-19" version="1">MSFDPRALVYVLSCCCFIKSCLQHFEFGLGVFLGPRLSRGLREGLPSGVFQHHAPSCKFQDSQAHREILSGRTIHYQTREKLPKEKNILSEVAQSQKNTHVMPSLISGYYTRSLKTQDTIHRSHEAQEEGRLQCGYFSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6E6</accession>
    <name>F9W6E6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000854">
        <property type="protein sequence ID" value="CCD12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36050"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20167" checksum="011E144EC9A4B489" modified="2011-10-19" version="1">MSQSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGNPEKINLYRFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6G3</accession>
    <name>F9W6G3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1460</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000863">
        <property type="protein sequence ID" value="CCD12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36210"/>
    <dbReference type="OrthoDB" id="235955at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="SSF159042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="379" mass="42018" checksum="0B4B4BA860C51375" modified="2011-10-19" version="1">MRWRQGYSLYQIVRPVSNELLVFDMIHYEEMHGMEVVSNAPPVAQEVSTWGKRMRAASRPFVTPGFIEAKVGDVDSALRTARGVSLDRSVLQPHTMITPSTPPVSGGDSYVRRARKTITAHSHSLALFSFDRLLLRTNDTLLHSQVCVLCEPERDNFNVVIFASRLSNTHAGKPRRSDFAGCMITLDKDSRVPGVSADRDITEKGYEMLCPPQWWGRRYIALGRQRPAATNVPYCDSRGTWRQDYTVLSGRFLTSLFNPPTSTSLPLPLWACGEGVAVTVMRPHLVVHHKKLHVFYLIQVVTTPSVRSVSGDRSSFCETLNPSAVISILPVDDVEEERCGLEVSLGSSDMSPQSNAPSSAAPTRTCQYGLAHAVCEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6I3</accession>
    <name>F9W6I3_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase B-like</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_36390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Putative phospholipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phospholipase B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CAEQ01000878">
        <property type="protein sequence ID" value="CCD12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36390"/>
    <dbReference type="OMA" id="FENTIRM"/>
    <dbReference type="OrthoDB" id="724258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PTHR12370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5011327834" description="Phospholipase B-like" evidence="5">
        <location>
            <begin position="32"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="301" mass="33174" checksum="09856B5C8B098CA1" modified="2011-10-19" version="1">MKPTTAACTTSSAALCVLFASTLFLANGAGAEILQGRNGTTVTVRYNATADTFSASADASFGEAAATLTYNDTFLESGWDIVSAVAVDSFMALPGEVEPSAERVALAYRAVGYGEGYITHDRMRAAMNNTFKGPEGLAALLHDAPQALHWIDEHLRYMEAAKYKSGPFFAQLRNMLAMLDGMVAGYNDRLAHGEGKLDKTKLLIYNMQAEIGDIVRGVALPEVLEDLEQMMPRWFTETHCSALVKVVKDDIFFAHATWSSYNSMMRQYKTYTFGNRFVTMSSYPGALHSIDDWYMTHSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6J8</accession>
    <name>F9W6J8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1482</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000887">
        <property type="protein sequence ID" value="CCD12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36530"/>
    <dbReference type="OrthoDB" id="576657at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="191" mass="22436" checksum="807C0FCCFC0E239F" modified="2011-10-19" version="1">MGKLQVVDLRNGHHDFWDMLAGREGGDQLVETMPEKQEVEGHSRRQRLRVFSDLSFKSSRHEDKQQTHLLQWAKDREGFLHLCCEKLEIGALGVSKVKKVLKLLQPEFIKELELNTVGNLSKLTKLVPCISKMRNLQKLMLVRIFGRHTYTPLEERNVTKILSLFPKLSYLQHLTIDDVYFLRDHMNELFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6W7</accession>
    <name>F9W6W7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000942">
        <property type="protein sequence ID" value="CCD12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15029" checksum="3F5D52659C2BEC82" modified="2011-10-19" version="1">MHDSVLKLIAAAAKRRPIGRCPVKHSPHRPHVCHGADPLPPSLLRHDIRRCYTNVPAVTVAGNEPYARLGPKSQIFTGPLVMFSARSQSSSLGGKSCDERVCSALIKKTETLCELLVAPLTDYCRGVGIVSRLRHNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7F7</accession>
    <name>F9W7F7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1602</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001022">
        <property type="protein sequence ID" value="CCD13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39050"/>
    <dbReference type="OMA" id="VEQSHEC"/>
    <dbReference type="OrthoDB" id="23800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="PTHR16453"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1110" mass="119028" checksum="C3C7F680D3E19D21" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7H7</accession>
    <name>F9W7H7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001037">
        <property type="protein sequence ID" value="CCD13143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39220"/>
    <dbReference type="OMA" id="ATSDMAN"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="279" mass="24480" checksum="0F622027F6BC3B45" modified="2011-10-19" version="1">MTDFTGIFPSASTASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSAASTASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSAASTASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSAASSASATVTSGSALSATSTASATVTSGSALSATSTASATVTSGSALSAASTASATVSACPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7P5</accession>
    <name>F9W7P5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1637</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001061">
        <property type="protein sequence ID" value="CCD13217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39870"/>
    <dbReference type="OMA" id="KSAFWQI"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="507" mass="56667" checksum="CE4DF05F62C96602" modified="2011-10-19" version="1">MVGKAKWKPLELPLPKKIVNQKQYRIPGGIAEITATIKDLKDAGVVVPTTSPFNSPIWPVQKTDGSWRMTVDYRKLNQVVTPIAAAVPDVVSLLEQINTSPGTWYAAIDLANAFFSVPVHKDHQKQFAFSWQGQQYTFTVLPQGYINSPALCHNLVRRDLDRLDLPQNITLVHYIDDIMLIGPSEQEVATTLDSLVTHMRIRGWEINPTKIQGPSTSVKFLGVQWCGACRDIPSKVKDKLLHLAPPTTKKEAQRLVGLFGFWRQHIPHLGVLLRPIYQVTRKAASFVWGLEQEKALQQVQAAVQAALPLGPYDPADPMVLEVSVADRDAVWSLWQAPVGESQKRPLGFWSKALPSSADNYSPFEKQLLACYWALVETERLTIGHQVTMRPELPIMSWVLSDPASHKVGRAQQQSIIKWKWYIRDRARAGPEGTSKLHEEVAQMPMVSTPVTMPSAAKHAPIASWGVPYDQLTEEEKTRAWFTEGSARYAGTTQKWTAAALQPLSGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7V0</accession>
    <name>F9W7V0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1657</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001083">
        <property type="protein sequence ID" value="CCD13272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40410"/>
    <dbReference type="OMA" id="KREMRRM"/>
    <dbReference type="OrthoDB" id="1654773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="808" mass="91883" checksum="B86D3F6C79E976E5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7X9</accession>
    <name>F9W7X9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1673</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_40680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001101">
        <property type="protein sequence ID" value="CCD13301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40680"/>
    <dbReference type="OrthoDB" id="563702at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="PTHR11626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16518" checksum="11696508F7553903" modified="2011-10-19" version="1">MVADALEHLPHVIEYLSNLRDSTIFAFCAIPQVMAIATLSLVFDNGDVFHTKVKLTRGATCAIIYGSTELQSALRLARAYGRQVLHRTRPGAEGHEAVAQSVAAALATMDGVALQQKVAVQDGLTPRLLERYSALGGGLLLKIAESVFSIWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W838</accession>
    <name>F9W838_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41210</name>
        <name evidence="3" type="ORF">TCIL3000_0_49610</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001129">
        <property type="protein sequence ID" value="CCD13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001469">
        <property type="protein sequence ID" value="CCD14328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14942" checksum="AF830C06251760CF" modified="2011-10-19" version="1">MYAQEHEMEATSNACKPSPALHTEEHVESLLRCPSSAAFGGRSQQVLNMPGINPRSSDTRTNGKDLRLWSISCMEWYREISHAEPLIARERSNRSPEAKCEGSVGAHLLVRLTLRVRVTECGVPTPKRKPRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8I1</accession>
    <name>F9W8I1_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TCIL3000_0_42590</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">IL3000</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="CAEQ01001170">
        <property type="protein sequence ID" value="CCD13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42590"/>
    <dbReference type="OMA" id="FDERQAV"/>
    <dbReference type="OrthoDB" id="556111at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14298">
        <property type="entry name" value="UBA2_scUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033864">
        <property type="entry name" value="UBA2_scUBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="177"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="304"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="597"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="648"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CCD13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="732" mass="82190" checksum="78EC07BBE28C52FF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8J4</accession>
    <name>F9W8J4_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_42720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001171">
        <property type="protein sequence ID" value="CCD13526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42720"/>
    <dbReference type="OMA" id="FSYDRAR"/>
    <dbReference type="OrthoDB" id="181796at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="711"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="775" mass="88486" checksum="396F89F3F9ABD947" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8L0</accession>
    <name>F9W8L0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1743</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_42860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001179">
        <property type="protein sequence ID" value="CCD13544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42860"/>
    <dbReference type="OMA" id="TMASELM"/>
    <dbReference type="OrthoDB" id="1218013at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="PTHR15840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="SSF143870"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20512" checksum="1E7344837E4736B6" modified="2011-10-19" version="1">MERIGEFSVMTFHNVRNGPALHSHFKSSQIDAAVIDAAYIVSHLHLAAALHRLASSPLVFEPHAAGPSAEAGTTLLPQREQQARREPERQTAVPTARDVFASLSHTRNLDRVMERLTCGSTTTAVVIVQHAPSSSQLQAVAEFVEGEQHSLSELGLYYSEAAVRDFYGIGEGELNLEAAVVNRLSTSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W912</accession>
    <name>F9W912_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 181</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04580"/>
    <dbReference type="OMA" id="FTECLAT"/>
    <dbReference type="OrthoDB" id="1655130at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="736" mass="84433" checksum="EA419AACF48B3FA5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9E0</accession>
    <name>F9W9E0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 185</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001299">
        <property type="protein sequence ID" value="CCD13840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04920"/>
    <dbReference type="OrthoDB" id="1696056at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="211" mass="22661" checksum="779BE46383BABE48" modified="2011-10-19" version="1">MGLQAVRKHETMRVETLGSHAGYLSYAVRFGFSPTSHVLQHPPLWGQKGIDRLGLGVGRRAKQLRRTIGNLEKLGKVVKGGISVLTTFASEVVFPVPLGPVFRLLWRKTLETASQDLVKPGRISAGYWCTTHGVVSLTSCLLHDHAKGSGGDDKPPGTLLSRCESRKRARHRILWKGAPGVVAFLGVAGPAPGAAMTGVRGGCRKILRDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9N3</accession>
    <name>F9W9N3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_46220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001333">
        <property type="protein sequence ID" value="CCD13937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46220"/>
    <dbReference type="OrthoDB" id="1703241at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="221" mass="24478" checksum="4E202820BB4C14B5" modified="2011-10-19" version="1">MVSSTETATQEVPPAEIPSQTPHSPPRGHRAMHLGGGWTGARLCGSFRAADVDLLCSPHPLCTLLLRLSALRAAYHSIFTPSSCTTLTGLGWVTLLSRTSRHPNILTLLVSFPLRHHHYQQLCCGPLACSAAERLWFAVRDSDFIHNCFSFLYFLIIQLAIFTTVLKLLSKLCSRGTIECIKEAALRWTNLIKCYVNLLTIGKILFSISVTPMPLINALYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Q8</accession>
    <name>F9W9Q8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1886</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001337">
        <property type="protein sequence ID" value="CCD13962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46470"/>
    <dbReference type="OrthoDB" id="1783609at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19107" checksum="AA98B09CCAAF1080" modified="2011-10-19" version="1">MSKGMANDVLSKNVLSPIAFFFSLLIIPLPIQRLLLRMCSFVSFLLPSVQLVPERQNSLRLPPLLGFLLLLQLSSRKPNRCVPSDCWKDRNENNNNNNNKWLSATAAPHSGKGPLSLTNKDLLTVCFLNAVALSGAVLFRFKAPFFLVVVVCLFAFLFSSLELLPTLLECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T0</accession>
    <name>F9W9T0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_46690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001342">
        <property type="protein sequence ID" value="CCD13985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46690"/>
    <dbReference type="OrthoDB" id="1679286at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="34971" checksum="EE0E92039E80121A" modified="2011-10-19" version="1">MVFSRAFSHRSSKHVLPLPSNTFKPFPDLTLICWCSTHLMLLGSNPFPPRISSEYSSGILPLPLEWTKVDVRSGGFRIRRRLQRPTWRPVLTPFLRYLPAIAIIMTDLLIYLVVPWCLLHCHLVRLCLAATSGQLFWVFRRALLSSFYGFTRGFPSPHKGICCHGSRKFCYRAARARFGLLAVHGIGCVLPCCFPHGFVLRLLLVVLFFCHCFLFRSALISPVHAFASIPLQVRNRGEAPGSTHFSSLEPVLVAFTYIRKRTPFNVLSPCGCHILAFHWSPLSLRFSGAVLPAPRPRDFHARPFHPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U0</accession>
    <name>F9W9U0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 1897</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_46790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001349">
        <property type="protein sequence ID" value="CCD13995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46790"/>
    <dbReference type="OrthoDB" id="1690970at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394629" evidence="9">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="248" mass="27145" checksum="94FBE91879E3D16F" modified="2011-10-19" version="1">MLMVPRSTWWLFLSVVILLSPDAAFCDGPKAIPTKAGAAICTLSKTLKDVTPWATQQVEDGAAKITHLEMKLVEWQSKFIQSKFKGSGSEECKITGLLFRQVKNEINKARAEVERLEKEASKASAFAANSAGRLDEFITVFANASWGSNYCLGDTSAAKPENLKDCFNRTDFSEESLVDIGDRASVKEPNLDSKINGIKHQSLKDSFADWSSAGCNLIKGAKEGILKSTNLEESLWWGGGILTIGKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Y0</accession>
    <name>F9W9Y0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001363">
        <property type="protein sequence ID" value="CCD14035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47150"/>
    <dbReference type="OrthoDB" id="1728766at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="19896" checksum="E9FBCEA76B880ADB" modified="2011-10-19" version="1">MDILAEETGTRRDLTDQPWPGAPSWYTDGSSFLIEGKRKAGAVVVDGKKVIWASALPEGTSAQKAELIALIQALREAKGKIVNIYTDSRYAFATAHIHGAIYRQRGLLTSAGKDIKNKEEILALLEAILAPKKVAIIHCPGHQRGEDLVAKGNRMADLVSKQVAQGAMILTEKGNLPKSPEDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Z8</accession>
    <name>F9W9Z8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TCIL3000_8_7480</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein TCIL3000_8_7550</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_00510</name>
        <name evidence="2" type="ORF">TCIL3000_8_7480</name>
        <name evidence="3" type="ORF">TCIL3000_8_7550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001367">
        <property type="protein sequence ID" value="CCD14053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_7480"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_7550"/>
    <dbReference type="OMA" id="YIHALAT"/>
    <dbReference type="OrthoDB" id="1545513at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC92519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC92526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14766" checksum="10EAE16B86EDA722" modified="2011-10-19" version="1">MVSALSLEVNVIVIPAFIVFVLFIIPIPLLSRVMSRVLGYLERVNFYGVSLLTIAMVATFLGFVSQFFEWRKRYGGAKPNFVDVAMEIDWEGKKWRHERNMYIHALATVLCSAVVKFARLHNALEKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA05</accession>
    <name>F9WA05_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_47280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001368">
        <property type="protein sequence ID" value="CCD14060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47280"/>
    <dbReference type="OMA" id="IGDECSR"/>
    <dbReference type="OrthoDB" id="1656576at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="637" mass="72403" checksum="3452F4113FE8D543" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAF1</accession>
    <name>F9WAF1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_48590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001426">
        <property type="protein sequence ID" value="CCD14212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48590"/>
    <dbReference type="OrthoDB" id="1667406at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394806" evidence="3">
        <location>
            <begin position="24"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="390" mass="43990" checksum="014F6C999C7880DC" modified="2011-10-19" version="1">MTIWKGMLAMLMVIVMVMRGVRGGYVSDYEPGLNFNGAEYDALCGVFQASLDLWNASRTSEKGLDKILEASLIQALFWNIGNKYLNGITNTLPKHYTYRKLFHRGERCGRCQNKDKFYFPGSSITHDLMCLCTPGKDADPFYGSLWFFYSETGFKLCGKEAKDMVSGPDNGWHVNGKNKEMNGLEKPWRAVVMGCFNGWKSKTGEWNQDIREKVNNLNATMQNFTKLLKQIKDHHKFGGFDEDREADGSSEKHIHVRYGTCPRGRAPWWKRLNEALYGKKPDDLLVERTSNQPDAGSGELQLESTMEESLEDMAEEAEGIKSEGHTNQAGTSSQSSNGNKTVSQSTTNSNMGPLNTSETGNSTYPRLEYLRSHTPKIIPCSWLLRASFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAH4</accession>
    <name>F9WAH4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1974</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001435">
        <property type="protein sequence ID" value="CCD14236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48810"/>
    <dbReference type="OrthoDB" id="1514176at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="44099" checksum="AB8B3BF809838CF8" modified="2011-10-19" version="1">MFFVRLCVLPATAKKRRKRKRNPDTDLGMSRDAAGGELNPLWPRGEELGPPSKQATMPARRTKLVFVYSSDDDDDSIRPVAVGKGEGGEMQKNGVGNSSGGAVAVVLEKGACLMPPPEELSLMCQEAADWKSKEQMKGRFDDEMPGLVEDLKGVVEPVRRERVKVVDALPLREVATLRKYLQAEDVSGLKHSRKRFREEEGGCQDSFDPITEGAEGPKPLFDSDGLVRSVEVNGYFLTVDETELQDSNGVEKVGEKELEYSNKTGNGVLHESDDEQEGGEGRSSAPGEEEESQWSEEVGEDFEEEEDEELDAALVIAVVEQLVRCCESDELDEALRDDGNEFLARVRPLLERVGTGSMEASAFEEEVRDDILKLQRALKRASRPKEHPIVINDVVMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAL5</accession>
    <name>F9WAL5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_49250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001448">
        <property type="protein sequence ID" value="CCD14285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49250"/>
    <dbReference type="OrthoDB" id="1674926at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390067" evidence="5">
        <location>
            <begin position="20"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37694" checksum="C23A604B9091C9F4" modified="2011-10-19" version="1">MMKFLFFVIVFILGVAASADEKNHNGPQHQALCNLMKAAVGKWGEVEKRVPTDPLRKALRTTLFGYGTVETLETLKSSLPKDYEGVEEIPESRGLWCGEPRGEEWDHGNVHQNLWSGHSAPHDMMCLCTVGDKGFPLNETSSPNEKLCGKDKDALGASDKQGWTGSESASGSKHVTATWENITVPCLNGEAGGDLKQALNEFLGKLENTTVKGYTNRRQLGAGTPDVIGACDGSTKRGVCVEYYLSMTPKPWWDDLQKAIPEDEKLQKRREEEKRKQQEEAAKKEAQKTETLKSGHPTTNQTEQNNHHSNLTDKLRRYNLTSGTLITPPCIWPLGAVFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAP1</accession>
    <name>F9WAP1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2000</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001463">
        <property type="protein sequence ID" value="CCD14312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49460"/>
    <dbReference type="OrthoDB" id="903255at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="41526" checksum="E9E34BB8989FF88C" modified="2011-10-19" version="1" fragment="single">MDGRLAHTEMLCDEIHGNLMGSTASSIQQLCQQVRQLRIDVGKLVNEDIPSLSDNVTALQEPHLQIEKICRSNVLTDKCQTPASIVFGADSLLRCCNELSSRVRLGCHRLENKETAKSNIYAIGYSTVYTTRRYKGYAAEEGTVDNLLSSEKVINKPGEMPKNTPRKEEGETKINRTGHQETYQPKGNCKTLTTKKESVQDIPSNKPSHPSAAESDLHYSNESSRSSLVFDDESEEDIKPQVSHETSTATPVFRQPAATGTISAFGQPAAADNKPAFGQPAATGTTSAFGQPAASGNKPPFGQPAAADNKPAFGQPAATGTTSAFGQPAATGTTSAFGQPAAADNKPAFGQPAASGNKPPFGQPAAADNKPAFGQPAATGTTSAFGQPAATGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV4</accession>
    <name>F9WAV4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2020</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001486">
        <property type="protein sequence ID" value="CCD14376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25709at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17711" checksum="8A839A228CC993C0" modified="2011-10-19" version="1" fragment="single">MNETSAMDNCGCLTDHPEVHKMEYRRPLGDKLHMDCLQSLVTTSAEEIVLHGVFGEEDCIRQLDALVSVQRRIPARSDGANALVLAGNVLTSAILSSQLAMHRWNVLEAQTVAEASEKLKREYVAFKRRVCNDEHLKAISRAHENVLNKASARGSEWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAW4</accession>
    <name>F9WAW4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001489">
        <property type="protein sequence ID" value="CCD14386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13330" checksum="A2DC92C3BAF1B5A0" modified="2011-10-19" version="1">MHNTKAKLKGRETLTDRVLRSLKKCVGPSALGRRHTPGSHPRGDLASVQEATTRTSIPTLPGSRCGGSGAGFHTSAVFHRGVSRSYSNLSPSMAWVIEHVNFIPMNMLFSKKHSLIKMDNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ9</accession>
    <name>F9WAZ9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001509">
        <property type="protein sequence ID" value="CCD14425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50410"/>
    <dbReference type="OrthoDB" id="1718641at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18971" checksum="03F1E125D88424E6" modified="2011-10-19" version="1">MERHLIFPEASLIQSGLPATRQRFGVMLARHDFVSFYSNQSEKFKPFQYKTEPLMVSALFAFIAPAAICWCAFTLSCTFRYSVVGSFFPLTSNVLTGACFIHTDSPSKQTDKYPSSSNKCRRTAFTFTSHSQGPINFVMPHKRSCQSSCCCQWRAPQCVWLNDAFMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB21</accession>
    <name>F9WB21_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_50630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001519">
        <property type="protein sequence ID" value="CCD14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388929" evidence="2">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14263" checksum="79FB2B857FD5A379" modified="2011-10-19" version="1">MRGRSPFHVLVLFVAYKLSFSYKTRGDGTYSQYLMVYATVGAQRGKIRNVLRRTGLAGGTSQGVGGIACGSRVIGENAATPLHVFYSSIFLVACTPFIPLPLLLLIVCMLLALIIIINCTLRMVFRPSAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB77</accession>
    <name>F9WB77_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2072</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001544">
        <property type="protein sequence ID" value="CCD14508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51160"/>
    <dbReference type="OrthoDB" id="1709025at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19776" checksum="98C26D3A79EC5450" modified="2011-10-19" version="1">MPHAHQWMRPQGLTHLLPGDTIGSQHITCHSHLRDSSGHIKHMSDTMWSRTHSQVPHSSLVTEHPGSNTSFPLPSARQGKFTAYQHSTARPRGKAMESALSKPFLAVARQATAKGAAQRGLILLRVLCCQSYQLIMPSTDFSHKMRSSGLPPQRHNHRVADMLPWRDIPPVAQAPPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB78</accession>
    <name>F9WB78_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001544">
        <property type="protein sequence ID" value="CCD14509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1891521at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13561" checksum="6BC6D001A395EB17" modified="2011-10-19" version="1">MLSSHRLVALSASTFLLHRFRASLFLSFLHCCTITFSFVSSGVQKGGTTPLPLCIAFFAAYLTPFLSASLSGSTPFTDSFILWEVGLSLISRNSSHHALPRAGSTRTGFESAITSMPTPTIISNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB97</accession>
    <name>F9WB97_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_51360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2"/>
    <dbReference type="EMBL" id="CAEQ01001549">
        <property type="protein sequence ID" value="CCD14528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51360"/>
    <dbReference type="OrthoDB" id="7046at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="8">
        <location>
            <begin position="26"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="7">
        <location>
            <begin position="156"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD14528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="33049" checksum="56B2E891735B2AF5" modified="2011-10-19" version="1" fragment="single">MAYSYTEKKRIRKDFSKLPDVMDVPYLLAIQLDSYREFLQAGATKDQFRDVGLHAAFKSVFPIISYSGNAALEYVGYRLGEPAFDVKECVLRGVTYAVPLRVKVRLIIFDKESSNKAIKDIKEQEVYMGEIPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDRGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDCVFVRIDRRRKLPASVLLRALGYTTEQVLDAFYTTNVFSLKDETLKLELIASRLRGEIAVLDIQDEKGKVIVEAGRLITARHINKIEKAGIKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBA3</accession>
    <name>F9WBA3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2081</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_51420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001553">
        <property type="protein sequence ID" value="CCD14534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51420"/>
    <dbReference type="OMA" id="KWTATFL"/>
    <dbReference type="OrthoDB" id="350086at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="239"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="373" mass="39947" checksum="5EC069ED6A2621F1" modified="2011-10-19" version="1">MVPPKYVESPCFPIHSIVRRFDLTAGGGSVGTVMQRVGTQPPSVTRASDGGIIQGTMDLVLFPCQLGDPTRPTGWPPAGQQDFTVMVNESYVTSGFPRCPTRSASHRTLAGLPLSPFLPRAPDGTIAPEAQLKICVVSRGKWTATFLLAWCGVVEIDTVVERTVSRLIKEQRATPRQEDLSDSSSASASGVPGSVEDSDIDIDSGWVDDAVDGAKQPGGSGEVCGMGSSGCAADRTSGHDPGVDDGEAVVTLRCPLSYSRIQMAGRGRHCTHLACFDVVTFVKSCLRSNSWNCPICDGPILIDDVRMDRTVQAAIDSLGPDEYSVVLFGRGYKEWRRNDCVPCVSDDDDECESTRGVDLSSDYHQSPLKSALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBF1</accession>
    <name>F9WBF1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001571">
        <property type="protein sequence ID" value="CCD14583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51870"/>
    <dbReference type="OrthoDB" id="1699155at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="185" mass="21907" checksum="8CCE5A04C8D365F9" modified="2011-10-19" version="1" fragment="single">MSLYTITSPRTIPWSMERDVADVLLDGVTSPDRINLYWFLRPVCPGLTVDFVCFTLCDFVRNPRHCIPEANVCDALWQYLPYLLWKFRQSAAPLVKHFGPTETWKQWEWDSWNIYIDMDDTPLEAINEVIWRKCRRPPVPQYQPCQGSFWSTRQLRLSRCRILPWGTSFLFQFLPAYGLGFETCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBJ5</accession>
    <name>F9WBJ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein TCIL3000_11_13390</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_05510</name>
        <name evidence="3" type="ORF">TCIL3000_11_13390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001587">
        <property type="protein sequence ID" value="CCD14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.13390"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05510"/>
    <dbReference type="OMA" id="EFSEFMM"/>
    <dbReference type="OrthoDB" id="1350916at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC95833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="196" mass="22031" checksum="134AB831561B6C0B" modified="2011-10-19" version="1">MVEPVKDKGAAAGQQDHLNKGGSVGALPISDVRGTSRPFYRRQMSHNTIAELAEGYRVLSNGQKAAAIPMKDVAALMSSVGLHLSEEEFHEVMRVFGRGEQTNTEELSFKDFLALMTCEVDDTMLEEMRSAFLHYDKLRSGYVSRKQFTELFATRGECSSPEELEELLAVAEQDDMDDKIDYNKFINELAHRLNCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC69</accession>
    <name>F9WC69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 219</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001676">
        <property type="protein sequence ID" value="CCD14861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05700"/>
    <dbReference type="OrthoDB" id="1248956at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="409" mass="44934" checksum="A67E84D2894B234B" modified="2011-10-19" version="1">MKPLPAVGDGSAAEVSEQRMQAEQFLCELSVAMPILPTNVTVVGTKLKKRKKARASGTLYLRTYCDILVLCLCYVISPSSPQWFTSLYRSAVEILYTLQVCFPRGTGGRLPCDFLAEHSLFEIASSFSHLSSVFILSRGVETQRACAQMAKAIRLIICSPATRPPVRPTVTQPDVQDSVGEGGGDAVPLVWSLATQSTLLDLHKLISKSEHSTGSSSGLLSSLELSSKLKILNARHVRNRSMFCGKRRGPKQFDVRKLEIVADLGTSDELCLLSRLAVSVAENMEKTLALKRKRSGNPAAEERVSSPTNNLSGKWVVKGERRLWHKRDNGLRRQISDLVTKVWNDASRSPAGGEVAVSSFQGASAVRKILVPCGSAAERWLLGKLWLQIHRVNDKLPMFDYRTATVISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC88</accession>
    <name>F9WC88_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001685">
        <property type="protein sequence ID" value="CCD14881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="14123" checksum="524FA4D5979C32A7" modified="2011-10-19" version="1">MDVRKSSERCSSDENCREGEIACVAAAHCQFSFYRTRDVYLAFCYCGCSVERQHMRCFDVYPAVYIYTSFTWLFTVFIGTDPLTYHALYRGCVYIIVFFLLFWKGRNKRNRERGRRAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCA2</accession>
    <name>F9WCA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2203</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001689">
        <property type="protein sequence ID" value="CCD14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54650"/>
    <dbReference type="OrthoDB" id="1672899at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="36982" checksum="630478C79333216B" modified="2011-10-19" version="1">MLVNYFFVYIFFFRAAGRIGRLDTKTMAGTRSFNVTALVGLLFYILYCIGLSAANYNICAGESNHNRDRYEDCVDAVCDMAEKLGAVPVAAGNLANEATSSALACTLAVKYIEETLTKVTYVADGGKPNGGVAGASATIKKMLTEAQYAANISIKESLRVEALLRKTKRDSKTAKRGLQGTLAYIVRMSCSYSGTPLADEVVEAQCNASEKVLLNCTDKQATAGFDILDRAQRRLFSLITDPNKVTNERVPPNTLWGELLSIVALEMGEIEKSTSIVRAYTKQILQVQNVVEQMASVIGVNVPVPAELRMISKGENIATETVYCVPVTVSILLLLLVASCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCQ2</accession>
    <name>F9WCQ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_56130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56130"/>
    <dbReference type="OrthoDB" id="1664216at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394876" evidence="4">
        <location>
            <begin position="18"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="89"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="47751" checksum="4D3BC913042A8B8C" modified="2011-10-19" version="1">MNVIVFFVVVMGNVVSGELEIDRDDNIEPFALLCRIYNVAKNHPINDVDLQEPVEIVQEIDSLNTMLVDPKLVNETEPMENSVGVQLHHTATREAALAQLSLNQITQRAHKVLDEINKMNVTKATEKVKKDFHKVIFGEDGNESDLCHATVNGMDNRGDVCGKPGQGSSGNGAGKNLVVDFFCLCAMRTESGEGAKQVCGFYVGKIDKYYGWSEQGLWGSSTMWASIKGGCGKHMHQHPKSTSEARHILDQFLKHLKTGGVYRHIKCEPGTPKCKNALVEGSGRKEGMLGTGITVSGKSEIKCDGKEGGREGKKSENVNPGGVCVYYGPDKWEENIEWVKHFQTALKTLESVNNQTATIQRAIEKLQMLLHRAEEIYETTKVMLEIQKLVGLPAALQNESGNLTAYNNTRTRSHSYNPNLYFIPAWALFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCR3</accession>
    <name>F9WCR3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_56250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001752">
        <property type="protein sequence ID" value="CCD15061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56250"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388984" evidence="5">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="44"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="393" mass="44349" checksum="570CBC00EC713F52" modified="2011-10-19" version="1">MMKIATWLLLWIGSGTWLGMDGPVARVSGRNEAANTLLCNVFEAAEAIRKHANVTKDIKDKIHTAVYGAQGRTHFPEDGKFRFSSLTHYRRQYPRHTVCEYYNHNLGANQVDGAFAETLFGAFLCVCAPPITNRHGKLCGVYHWDRRRAWSGNFNRGNIDYLLLQDVWDEVIKKCTASTKRQESDLDRVERLYVALEAVRKGVRLYRPNGEFLYVLGDLRDIRGCSGRAGNDICAAYHQRVGRWGIPWEQHLRNLLPELYTRFQKPQAVRTQETVQWTTSVVPEASGTHETNLPPFLPPLPSREVLVDEEGYGVIVQDDDFPNDQPNSTDAGWEGENHTSVSAREPEAEKLQGIEGTPDSEDTVVAHLDAETHEDGSLITQPFWLLTAASLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCV5</accession>
    <name>F9WCV5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2278</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_56650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001773">
        <property type="protein sequence ID" value="CCD15103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56650"/>
    <dbReference type="OrthoDB" id="423426at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390185" evidence="2">
        <location>
            <begin position="23"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="556" mass="61579" checksum="38EA49C539AEF7AF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCY7</accession>
    <name>F9WCY7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2293</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001790">
        <property type="protein sequence ID" value="CCD15135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56950"/>
    <dbReference type="OrthoDB" id="1665409at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="410" mass="44322" checksum="395AF2DB0A5ED2DF" modified="2011-10-19" version="1">MSLTAERLDGIECNGSFSLYMSDDYNVGVYSLVGDVAFPRMQVAVADEYGFSLDLSRCDGWTVSEESLVGDDTAARSNISDGEWGDGCCGNRRALPAGTSPCEYDVENSTSCVWDCYTEIDALDMSQLSPRDVSLASEERGDTPKTLLTDYVLPQINLTSCAFSFSFRTASVQSIVPTPRPTVKENKCSFPSVVHGDKVRKGGAASEVPPSGAVTAVGPTKPQTGPVGATNVIRNMPSSAVRTTQSIRVGFLNRKEELLRRKFEKYECIERTAFLEHFANGLKAVAAHRNVFKRGTVSMSPSHTISNSTKPLDGRRNKTTIQAFPSTDNLFAREGLPKFPRMEAGSSLIFPEGEPRASTSAGRTAATCIVANTTSANATSFPAPNAFRKVPEGFADVRTIIHHKMKGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCY8</accession>
    <name>F9WCY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2293</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_56960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001790">
        <property type="protein sequence ID" value="CCD15136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56960"/>
    <dbReference type="OMA" id="ECADARN"/>
    <dbReference type="OrthoDB" id="936872at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019537">
        <property type="entry name" value="TMEM65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21706">
        <property type="entry name" value="PTHR21706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10507">
        <property type="entry name" value="TMEM65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38018" checksum="5036A2B6A368791B" modified="2011-10-19" version="1" fragment="single">MNMLQPRISRMRFPYSPLAFMPTTAMTMARASCCHLSALAKEERMKDVETLPSPSCSSALKTATAGALMAKTVLPTACGEHGVKSESTRAGADITRRGSAPIFWASKNSTGVKPNTSQSSKSGCSRRVSEELELAKAVERLHNILSGWYPAQTTDGKCNVERHQAKNPVDVKQAMPRNTRDELPAALAFILERDPVFGLQLLGELQGDALRKLLVISTTQEYLGREGVEKQLRQVDADQDNHISPSDYDRWMETVSRERAATRDVGHNGRAEEPQQAGSTSLHQSQSPSDNDISWSLWFRIACSAAVPFMAFGLLDNSIFVTAGDAIDRRCAEAFGLTSMGAAALGGVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD70</accession>
    <name>F9WD70_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2331</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001832">
        <property type="protein sequence ID" value="CCD15221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57650"/>
    <dbReference type="OrthoDB" id="1713562at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18502" checksum="FC21F95230669BA7" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFMFFRVIFSFPSPGALQNCFCNNYFMSFLVFRHPARCKTVFATIISCSFLVFRHPARCKTVFATIISCVISSFPSPGALQNCFCNNYFMLFRVIFSFPSPGALQNCFSNNYFMSFLVFRHPARCKTVFATIISCYHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA9</accession>
    <name>F9WDA9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_57970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001846">
        <property type="protein sequence ID" value="CCD15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57970"/>
    <dbReference type="OrthoDB" id="1667463at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="301" mass="34251" checksum="7BC43E098FFF5226" modified="2011-10-19" version="1">MENVRDLRRKAAEKRLSAKRHLHQVIFGDYGGEGKGELDTTPETVKKIFNGNTFKDSCGGNGDKMAGKSLINDFICLCAKWIKLDAVFNSHQDHSICKYGVTTAVEKDFKNWTDVWYFNKHRICINTAPLTPTPKIINSMVAHFTRMVDRDQTNFTIKGVFGFYNHSGKDKPCDASEQYPGNTCVNYKHALENGGIQWVNRLKNASKDLEDMERLNKKSESSLPQLELLEHNAILLYEEAKYSTQLPHANETAFKSTNESYEDILANDTNTLEKLEEEDDSDSTWKGGPSLCGFFFFLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDE6</accession>
    <name>F9WDE6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_58300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001862">
        <property type="protein sequence ID" value="CCD15299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58300"/>
    <dbReference type="OrthoDB" id="1669017at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389008" evidence="5">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="39636" checksum="96B14618870F4DD8" modified="2011-10-19" version="1">MRMVKIWMAVLVFVRVGSTDGAGEKKEYNKEEHRALCDFLKIALGTWGDQGSGLSEPLKAALKTTIFGFGSREESIEKLKSFPADYLEAVKSPGSRATWCGGPYHGGEDNGHSLNRWSGHSAPHDLVCLCTAGNYGWPVNETSPDNTLCGRSKEDLMGNKNEGWGSLGAVWDPNLNDLVIHDKGEAQIQATWSNVVTECLKGETGKDLKQALKTFIGKLNRTLEGKDRYMYRLGEGSYSKINHDACTGSSTYGVCVGYFPNRTNTKTWWKDLQNAFDVEEQQKRRAEEDATRRQQEHPAQKDEPQTAALTSARQTTNQTEQQRNDKLHEAIRKYNLTSGTPISQPTSWLLSATILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDI3</accession>
    <name>F9WDI3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_58660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001873">
        <property type="protein sequence ID" value="CCD15337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58660"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390184" evidence="2">
        <location>
            <begin position="18"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="200" mass="22948" checksum="2E098F7549C6776F" modified="2011-10-19" version="1">MPPLYTILSFLLHITHPLSPSPIGISMSESSSSPSPEGMAQEDNPWSMEKDVVEVLLKNIGDPEKINLYPFLQPAYPFIHSYVSRFSLIDFARNPWRCVGEADGREKVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDV3</accession>
    <name>F9WDV3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 2407</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_59770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001916">
        <property type="protein sequence ID" value="CCD15457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59770"/>
    <dbReference type="OrthoDB" id="674800at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="PTHR10332"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="340" mass="37496" checksum="D3FF3C8DCE40FFEE" modified="2011-10-19" version="1">MMMEVFVILMLPVIKVSQTVAIVFFVIVTILGGMGKCYLEATSYTLAASMPEKFTSTIMFGISICGVLTSMMQCIVKVSMENTYDSHLIQSYVYFSLALLIMAVALAMSLSLHYNSYAQEHVAEIRALKQKQEDEGVEPQPVADVPTEVKESTSCEDKCDVDSKEEGCITTAEQLSATPIMPVVRIIRVMLISCFLGFFLTIFILPSLVIPIDRVDDWFSTIAALVFNIGNSIGSFCTSFETFRYPRRVVLYVSIVRFLLIVPFILSIYKYIPGHVGPYIFSFILGLKHQVAVLSMVYGPVTHGLNDGQKLMTGQLMGIALLVGASAASVVAIIVVIFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE02</accession>
    <name>F9WE02_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001935">
        <property type="protein sequence ID" value="CCD15507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60130"/>
    <dbReference type="OrthoDB" id="1614643at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="514" mass="56811" checksum="C5F2BC174134D358" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEB9</accession>
    <name>F9WEB9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2455</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_61090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001970">
        <property type="protein sequence ID" value="CCD15626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_61090"/>
    <dbReference type="OMA" id="VHINEHT"/>
    <dbReference type="OrthoDB" id="1653369at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="4409" mass="517545" checksum="44859BA9672FC6F2" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF0</accession>
    <name>F9WEF0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002001">
        <property type="protein sequence ID" value="CCD15657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06750"/>
    <dbReference type="OMA" id="GREWAQS"/>
    <dbReference type="OrthoDB" id="1288652at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="23851" checksum="297931E5C53335C3" modified="2011-10-19" version="1">MPPSKVPDSASSGVGKKSEGRIKIVSTGPVGVGKSCLVKQYCEGRFVSKYIPTIGIDYGVKTVEVRAPTHLSPTGRLSVRVNFWDMSGCEEYLEIRNEFYRATEGVLLVYDVTNMESFTALNGWVKEMETHMNTKGSDTLVARADPSAPCKVVVCANKIDETTEKGGKKKRMVNEEAGRKWAKDRGYKYFETSACSGVGVEEAFETLFKDVVEAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF79</accession>
    <name>F9WF79_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_09330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="4"/>
    <dbReference type="EMBL" id="CAEQ01002114">
        <property type="protein sequence ID" value="CCD15947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09330"/>
    <dbReference type="OMA" id="NFIVHLA"/>
    <dbReference type="OrthoDB" id="815047at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:fatty-acyl-CoA reductase (alcohol-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09071">
        <property type="entry name" value="FAR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033640">
        <property type="entry name" value="FAR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="PTHR11011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03015">
        <property type="entry name" value="Sterile"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="7">
        <location>
            <begin position="16"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Sterile" evidence="6">
        <location>
            <begin position="504"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD15947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="600" mass="66079" checksum="6CC281E9ACA64A16" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF86</accession>
    <name>F9WF86_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002115">
        <property type="protein sequence ID" value="CCD15954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="12892" checksum="0B342A1F36BF923E" modified="2011-10-19" version="1">MKSACDKWAVLARSHRTHAWPPLLSSLPHYTTGGSICCRGVQPKSAGITHPSLIPTLHMPFPAASSIQLLTGISHGAVARPAVQHSNESHSELLRCNDHFSQSCSTAHLQALMQSHFIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFJ0</accession>
    <name>F9WFJ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_10300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002151">
        <property type="protein sequence ID" value="CCD16064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10300"/>
    <dbReference type="OrthoDB" id="1666016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394991" evidence="5">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43721" checksum="8290738F95D793C7" modified="2011-10-19" version="1">MMKLFMVCLVVMGGWVREGRVMANGDVSVDGNDNSQYFALLCKIYNVAQYPPIKPVDTKEYQKIVDDINALNAAVNGKERVNTQSEETKSAQTQLVGITRDAKKLLEEIKRVNPEGEAEKARNAFNKVIFGKNGKEGDLSQGALEVVPSRMAACGGKTQGKGTSAGKNLVVDFFCLCAQYNEDDVGVDKVCGVSVGSGRDSGWGTQLVTSDTMWGEIKQGCEKFDTQGTTSTQTGHFLYREFLEKVTAGGKIKVGSSENDRKPGMLGTAVSKTEKNNFNCNGQKTLTARHSSPSGSCVFYGEQKWEEHIDWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARGLYEKVKADSQLEEENTDDSPLAQHPNPDENENADSSTQSQRHSLLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN1</accession>
    <name>F9WFN1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 406</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002166">
        <property type="protein sequence ID" value="CCD16107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10640"/>
    <dbReference type="OMA" id="WHMANER"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="556" mass="63533" checksum="09F824A785D1E539" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFS9</accession>
    <name>F9WFS9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="107" mass="12973" checksum="1EE3254BF94F5AA9" modified="2011-10-19" version="1">MEFGKKGEFGKKGNLIKKGIWQKREFYKKGEFGKKGNLVKREFWQKRGMSQKNRIWQKGKFGKKWEFRKKREFGKKGNLAKNGIWQKREFGKKGNLIKKGIWQKREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG37</accession>
    <name>F9WG37_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 463</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002228">
        <property type="protein sequence ID" value="CCD16267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12150"/>
    <dbReference type="OrthoDB" id="1716555at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19008" checksum="6AEAC84C1E664F05" modified="2011-10-19" version="1">MPFFSGQRHFMFSHQIVFPYGAKFISYRKERKVRMKVLLFLIFLSVSVGPSCCSDENNHNGAAHQALCNVLKGAVGMWGKNGEHLSEPLRGALAHTIFGKDGTRNLDALIGSDLPDDYKKGILGSSRVYWCGLPRKEKEYGEKLQMRFPVTPRLTTCFVCARLGHWGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGJ7</accession>
    <name>F9WGJ7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_13560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002278">
        <property type="protein sequence ID" value="CCD16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13560"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20058" checksum="54400C46659D7288" modified="2011-10-19" version="1">MSASPSSPSPEGMAQDNTPWSMEKDVVEVLLKGIGDPEKINLYRFLQPAYPLMHSYVSRFSIRDFARNPWRCVGEADGREKVWEHFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGN3</accession>
    <name>F9WGN3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 522</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_13900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002295">
        <property type="protein sequence ID" value="CCD16470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13900"/>
    <dbReference type="OMA" id="MNTHPLC"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390356" evidence="1">
        <location>
            <begin position="40"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="118"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="456" mass="51045" checksum="EA1B4C206DCCC687" modified="2011-10-19" version="1" fragment="single">MVMNTHPLCVNRRHAPRTELSLSPIFLLSLLLLCAPRRSQQHLASASPVNVKVLSLMYNKNWPLQYINGLNAGFNASLAARNWTAGPGVSVAVVYPASYDIPSPKHLKNYLQQPGNDKGLLVVFGPMGESDALNSYATLEENNLVGFAPLTGSAEFDTYHPHLYFTRPELTAELISLIRHAVSYMRILRLGFMYITEEHGGLGEYRQAVSFMGKMGYELCCVFTVENSDRGPAPDAEFRAAWNGFAKNRPQAVIINAAIHSDTEKFVRMLVTDPRTKDAFLLAPSLLRKALVEVWKDALNAVNASFVPRRVKQTGMNPLAKDTFFKAIKRFQKEMSNYLRSSGNQDGFDDPEYFLHNDDVGELMVYGWIAGEVMMRALESNGKLDDRVAFMKSLYNQRRYLVDDLVIGDFGGECTDRAITNGAICRCSRGGRRVYMKEVVEGYRLKPLHSGYIASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGX7</accession>
    <name>F9WGX7_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cilia- and flagella-associated protein 91</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_14790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFAP91 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002346">
        <property type="protein sequence ID" value="CCD16565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14790"/>
    <dbReference type="OMA" id="HLNAQWS"/>
    <dbReference type="OrthoDB" id="496618at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026720">
        <property type="entry name" value="CFAP91"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032840">
        <property type="entry name" value="CFAP91_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22455">
        <property type="entry name" value="PTHR22455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14738">
        <property type="entry name" value="CFAP91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFAP91" evidence="7">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD16565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="492" mass="56387" checksum="12C359F503816769" modified="2011-10-19" version="1">MLYDLEVKERDDRERHFEKLRERRLHQIRETLEERERMRDEANRLRLEKVKGERLATLQRVIGKVEAKRATVERKALADTASKTSASAARGLYALDPIETLRRKTDLIDVYAKGGLRVAEIQHPKNAANTGKSPTRKRQLAYLSRYRQYDVRPTMLMYEEGINELEVNKIPKIQTIPQSAFIPPENHAINSLPSLYQRREATRVVDALEYVHTKIKKGDTPAETIRVLELYRATPRPQRPDTPVLELEGEVDGAEQESCILLQRLLRGRAVQNDFFDGKERCRGLIEELQAASNAKYAERSDEEKRAEEEAKLREAIVDSIATEAQGDIIYDTLDYLFHEMTRQQDIRALEALRHEAEAVRAEREAREAELRAQERILHDKEAVQYAAYVRAIEDVVECYSHDLYTTVVEECAVEEAINEECDRLEMLPSSTANITSGSQAAENLVCDILDDFVLPAVIDMVRLKPDELDRKAPAAASVEFTMSLANNERSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH34</accession>
    <name>F9WH34_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 588</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002368">
        <property type="protein sequence ID" value="CCD16623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15320"/>
    <dbReference type="OrthoDB" id="343870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="325" mass="36000" checksum="C04640B14D81FB07" modified="2011-10-19" version="1" fragment="single">MDDSALQRIRNGLALEKQGRLAEAEELLASGVGGLHKVMKDVSLDDSQRLLLVEYVKDATRHIQRIRENLRRCSSGTVTFSSPTPSVSGPLRPTAQPDRESDNDYLSFLDNVVQVKAPPAPAPSERVMKPREVIGSDPSSGAPQGLSNSRSVPHASDFVLRAVDVAATLAQRKEFKRAVDVLQHAYDVGSRQGVRPRNFKCVEEHLVLLRQEYYKHFKPRFLQDNPVLPGELEILRKSGFVKTLTLPIWDDLHEGYGSENVFMPCEGHWEDSFTPRLSPLQLSAGARYLRVGSAKPGAQFCVIRSADPLNVKQTVVGDCSVVCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHG1</accession>
    <name>F9WHG1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002431">
        <property type="protein sequence ID" value="CCD16754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15133" checksum="EA22EF346A8511F8" modified="2011-10-19" version="1">MRWLLSHRGVKLVPPWGQTGGEEQTARSNILDIRSAAWEPVSDSPSLLSAAESLNRKRSKTPSIQCNLIAVDVKIDCVGGEGMDIESSLQRGLRFLAFWGRRMEASAERAVHACIGIGRPNTLSLHINGNKLSGTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHK1</accession>
    <name>F9WHK1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 660</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002448">
        <property type="protein sequence ID" value="CCD16794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16940"/>
    <dbReference type="OrthoDB" id="774215at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26855" checksum="19A2C8111002AF0C" modified="2011-10-19" version="1">MLEDEGAAECLSDSRDSLYKRLQMKHAELRVNHLVNLRKTLEIENAAASKKFHKMPMSLDLISDEINLALSEITVRCEEHGVPQISHLVKEVRTMMNRQLREAYGHIEAGYKSAFHKLRETSEVQDRRHERTTVAEELNSKPREVAEPNDSVPPVGGEQCLNDKKADKNTDKRNPSGQKILSLTEAVSATTTFFAESIAVLLRCEIVRVYLYDDYGNLNLCARFPCDVTKGDPISGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHS6</accession>
    <name>F9WHS6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 690</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002481">
        <property type="protein sequence ID" value="CCD16870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17550"/>
    <dbReference type="OMA" id="GNCESIA"/>
    <dbReference type="OrthoDB" id="1694492at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1038" mass="105401" checksum="421055603B0E1D1A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI05</accession>
    <name>F9WI05_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein TCIL3000_8_7310</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_18300</name>
        <name evidence="4" type="ORF">TCIL3000_8_7310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002509">
        <property type="protein sequence ID" value="CCD16950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18300"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_7310"/>
    <dbReference type="OMA" id="KCPGVIA"/>
    <dbReference type="OrthoDB" id="1427850at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12" evidence="3">
        <location>
            <begin position="142"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC92502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="21180" checksum="ED60628BDC5E2A53" modified="2011-10-19" version="1">MLRARSAAGNGVAAGAAGFNITTALGRFFSIGVPSSATPRGMCAMGLRDSAETVEAIAEAYVNMELKTMRAFHELVAKQMQGPSGTNPMACEEMLLQGFGAGVAVNIARTAASAAGNSGGNQAAPVAAAPAAKRVVEKATVDVSVKSYPTGSKVKLIKELRAVTGVTLQEAKAAVEQCPGIVAKAVQRADAEKLKGLLEAHSAVVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI17</accession>
    <name>F9WI17_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002516">
        <property type="protein sequence ID" value="CCD16962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15189" checksum="84C0E63F3E6546DD" modified="2011-10-19" version="1">MFVCGAKRRLVSRVLLSRALRHFRHSYDHNPSGLPPPPYAPRPQAKCPRLTAFCSDILPLHAHGADHVFCTSLGTTRAFEPFAIIRLSTPTISVRSQNRGALLHLCDRQVTSLDALVAHAASAFLTTDMESSSENVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI20</accession>
    <name>F9WI20_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002516">
        <property type="protein sequence ID" value="CCD16965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00100"/>
    <dbReference type="OMA" id="LEPDYKD"/>
    <dbReference type="OrthoDB" id="1351433at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="242" mass="27308" checksum="5D7D8BA331FC5F09" modified="2011-10-19" version="1">MPNLGRCAFRYYEVMPVELEPSYAMGYDCDKCLKGFSKGPLFHCVKSGRDLCLSCGANVGLLPFSSLVSKVMWPCAVWMDAENYRVVTLCYQIHDDIIGCHFNDGSNLLISRSELSYFIEVNRTIDDAQRFSEDDLVARFPWASGIVEIMTVYAVSLHPLSTTKDLSRLCFLSSFRIEGPFIEFRLSDGFCELVHCDKGVIVVVRDTVPISCLTMNSPVKWSKVPPKVASPIIEWFLKDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI48</accession>
    <name>F9WI48_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_18620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002527">
        <property type="protein sequence ID" value="CCD16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18620"/>
    <dbReference type="OMA" id="CSAKDIR"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="306" mass="35022" checksum="CBFFC47BE4D30B16" modified="2011-10-19" version="1" fragment="single">MYPAWITDIVTGVERQVRNEMYRSFEEGRMLRTHRSVLLDHVRPAPKHTKLDRLEESLLAQFRTGTSKHFGWLHRVLTRKTDRLEYRWCSAKDIRGDAVEGHTLAKPAVDSANAPDLGIATRQSDPIICPLYNMVCARRQAGVVHLVKIHGLERECALAMTKKARRAGLTYKNGWTCHVCGDAFERRGLLVEHMAQHPPVVVPTVEERPKRAREEDEADDGKAFKCCWCAKRYTVYARLRKHMIQNHPEKQLKSDDIPVEQEASSDSGSEPVQEEQNFVCQKCNRVLKSKTWLTGHKCDVTANINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIB5</accession>
    <name>F9WIB5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 762</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002561">
        <property type="protein sequence ID" value="CCD17061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19180"/>
    <dbReference type="OMA" id="FHTEHEF"/>
    <dbReference type="OrthoDB" id="572447at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44266" checksum="9BDED757589F6398" modified="2011-10-19" version="1" fragment="single">MGIDEVTALVERGYAKIYGEGKGLFSHCSDSITCNPDGVMQLIRRLMEKDLPQIGYRPGATLCTLVVELASQYGDGEPSGLFVALMLCRLYSTLGGQTSTRDMPFLARRCAEHSLEVIKRWVSDGYEVLGTSNSWCPLRKKGVFQAVKLLFTRSGLLSEAHSIALAQIISQAALEERRIFFTLCNVHKLGAQQNLSPYAMNRDSGFGVEKGIFLSLQLPIEAQLLLATGRCSGSVLLFSCSLDIGGTRLQTFTNLLKSIQPDFVVSQRLLGPDLKEKLFDMGIVPLERLSLQFCGALQMVTGATPFHTEHEFRMWASSFIVQSKVTDNKLGAIQRVVLCSDQCMWVYGKDIVITVVLPGDDPVSQCTLMEVCERAARYASNSFVSSPEFKPSSVGVGEAFLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIH3</accession>
    <name>F9WIH3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 789</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002591">
        <property type="protein sequence ID" value="CCD17120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19690"/>
    <dbReference type="OrthoDB" id="346237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="394" mass="43916" checksum="60CFE87A7C8D2973" modified="2011-10-19" version="1" fragment="single">METPPRFPSSAGSLLPGLKPLVRVRPYRTRDLKMLMAGAVQLDLAQEIVLLHSVSEELISHLRKSSGETPCSRNWDELLDVKRIKRTDFHRAAAASSSVIAATSLGLWGSVDYCADILNSVRMRFLPHADVTRVNKKVKLQIRHFFKFLNELHIDVVVLSSDRTSAVMYLSTRSGSPSSQTAGQPPQVVANGERRFYDRTLLALEFNHADASWWPLSLTVAYENDNYVASLPKLIPENEKLLSDASAPMPRGRNGVLLHAHQLITDTESVSCTRTAYNPQHTENWKGCNAVQADCGDDRLTSPCAKMRYPNIEPLSLLFFSVILEGLRPTLYRNRMRFIVAVPVAILGFLLGILLIIYLSMNMLPCCHDVSSNQCVGSPSSSSYDAYCDETFCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIK9</accession>
    <name>F9WIK9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 808</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002612">
        <property type="protein sequence ID" value="CCD17157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20020"/>
    <dbReference type="OMA" id="MATYVCE"/>
    <dbReference type="OrthoDB" id="990923at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="474" mass="50904" checksum="D53A546CD03A8761" modified="2011-10-19" version="1">MAGTSCAEIRLRCRGAPDEGEGRQIVVVLGELATYLCWPGDIRPFAEEKPIPADLLGGAPTTDGQPVAETNKTRRQETSYLFLVSRLRRHLSDRNTILILPSHSSKEYRESVVVFCFEKLHVRTIIVLSDLVADSFGAGCRRALVLHASPSMISVGCVESGVTVRHKAVTYGSKISFLNDEVGNEEKGGLAQPQLVMETNEGRVAFRSGSNSSGAAEDLLKHLSAVESDCLGSSSPDAANEVDLLDEAYRDALVYLVGEDAYHRVVSLIQSDAVTDRGALPALKRSRVEGGDNSEASLSGVNGTISAAGSGLMTECKGREVEREEGALSRAISYVADGEPLPVIVAGEVFRVAPLLSKFIEDAVRTCRVQRESCAKQRSTTSTDEPLSSSTSLENTSTNSCTSSSSESSQPTLCDRNIPLQLQPLPIKELPWELALLGGSLVSQLSLLELCKLRISKDDALSSRGSVVHWRSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ50</accession>
    <name>F9WJ50_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 872</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002683">
        <property type="protein sequence ID" value="CCD17353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21790"/>
    <dbReference type="OrthoDB" id="1530870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="213"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="374" mass="42523" checksum="9615DFC65B8D21F2" modified="2011-10-19" version="1">MDIFLPPRPTRTVDLNTMSRADLIELAKKQSQNVREKAKRISFLEELVRDLTGQADLSGLGGANAQSAARSLSNSLNSTNFPQGREEERFNFADAMGQKEEVIKMLRQELDQKKKELEACQNNSLFTFTGASVAPDALERAVEERMAQWKEASKVQSAKDRARIEQLEAEVRVLRGNQMTVDSFFTTCDSTAQEQVIRERVEREVQEKVEQWQVRMKTRMDEDQEKIQNLQEKLNAYSEKAAEMLQSKEQIKRLQQEVELLRLQLAEALRDRDAALKTSGPLVASLEESWYDYLKSVSSLLSVCDERKKSLLLSADFVRDSLKKKDELFCNVMQAFRASSSKLEVEVLRVTSECARLQLRVAELEGAGTSSAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ62</accession>
    <name>F9WJ62_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 87</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_02400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002687">
        <property type="protein sequence ID" value="CCD17365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_02400"/>
    <dbReference type="OMA" id="PAVCMEQ"/>
    <dbReference type="OrthoDB" id="166083at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="926" mass="103365" checksum="F360E63D358E86D5" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ98</accession>
    <name>F9WJ98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 890</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002703">
        <property type="protein sequence ID" value="CCD17402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22230"/>
    <dbReference type="OrthoDB" id="1721261at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17413" checksum="7546BAF20053D6BB" modified="2011-10-19" version="1">MALNCIEAFVTLRKGRAGEAANFPADGVMEVNQTAASFRHAAIGGVSVACTMGHPKRSDPINTAFVFLRHQKPKLGRALQKRRVHAEHQKPKRLGHMGERSCRTVAPLSEAASRGIIRGVAGYLPQYFTCARSFIGMRRPSTEVEQHLAGMTYATPRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK02</accession>
    <name>F9WK02_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002797">
        <property type="protein sequence ID" value="CCD17663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="652922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15159" checksum="7AA75450C7F35B7E" modified="2011-10-19" version="1">MIVSITKSLIMLLVIQYHFNFRGGWKRLVVCSAANLMSGLLSPLLEYGAGLLLPVDSSTEMKPAPDWELLFLATLIGALLHHNITRYWWRRCPTLIATYILFLCALSSSSFHFISAFIHTYMYINNDRMNSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK73</accession>
    <name>F9WK73_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002818">
        <property type="protein sequence ID" value="CCD17734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="MFYIMVL"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="310" mass="33546" checksum="D5B8A9AB2310908E" modified="2011-10-19" version="1">MITVVTINLTRNHTPFLLLLLGLIFMFLGILPGLIFMSLGILLGLLFLFLGIFLLFLGLLLGILLGVVLLGVLPVFKVMFVVLPMFYIMVLGILLLFLGILLLFLGILSLLLGILLLFLGLLLLSLGLLSLLLGVLPLSLGLLLGILLSVVLLGVLPVFKVMFVVLPMFYIMVLGLLLLFLGILLLLLGILPGLLLLFLGILLLFLGLLLGILLGVVLLGVLPVFYIMVLGILPLFLGLLLGILLSVVLLGVLPVFKVMFVVLPMFYIMVLGLLSQKGGXLLLFLGLLLTSPWVPPWAXLNDPWSXLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W397</accession>
    <name>F9W397_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1022</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000376">
        <property type="protein sequence ID" value="CCD11605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25760"/>
    <dbReference type="OrthoDB" id="1710436at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="19181" checksum="DCD0E132C4563FE7" modified="2011-10-19" version="1">MQERNDNRVIGNGSLSAASGAEGFELHGGLCDPYEGKVGEAAKLTADGVTKTNQTAASFSHAAIGRVCASCSVGHPKRSDSGNAAFVVATPQKPKHGRVLEKRQVHAGYQKAKGLKQMGERSCRTVAPLSEAASCDIKRRVVGYWPQSFTCTRSFIGMRRSNTKAEQHLAGTTDATTRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3B2</accession>
    <name>F9W3B2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_25900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000386">
        <property type="protein sequence ID" value="CCD11621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15194" checksum="C4283BAFB246A70E" modified="2011-10-19" version="1">MRVLVFSMLLLLLFIIIIIVFFQMVLQGLVPVTFSHGIVVNIHVPPVVMPTTGNAGADFSPRMANGLGSPMLHTWLAAKAPLARCAMPCLSSSHTALVLCVLCSVCMDRCWDRGVMRYGSDKGVLSRNPRKHESIYPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F8</accession>
    <name>F9W3F8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1048</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000405">
        <property type="protein sequence ID" value="CCD11671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26300"/>
    <dbReference type="OrthoDB" id="1689711at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="227" mass="25724" checksum="169A4BDA2731FB41" modified="2011-10-19" version="1">MTGAGKTNHSEKQNYLSRDKRRTRLARDISTMAFVSHSRRRQNAPPQFALSVAYPCLLQPGHHGWKACGKREQRDARQSFSIPPPILSGTRAVARTGRQHNGTDGVPIAVLGIDTGRLSSDQRWEVPFICPRTKRLRNTTWHVGASCGEWHVTNITAHAPNPFFAFSLPSMYGSKYHNTPFDLSQLSDHLLAIHMRNLPRSRCTRQRLLSDLTWRPLVGTRCCSEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3H2</accession>
    <name>F9W3H2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1053</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000411">
        <property type="protein sequence ID" value="CCD11690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26450"/>
    <dbReference type="OrthoDB" id="1663441at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18440" checksum="AD15098F94071EF8" modified="2011-10-19" version="1">MREFTTLLKQSGGHDRLGGFEGHHTPSDGSDETSLHVLYDTCDGKRKPWWKILNETLHKNHPHELVLNRTPTTLHAIGASLQDRTKGEEVRAESMEDQERTSAQGGNATWGHALNSTQHRNTTWRERYEQEYRPYIQHLRSHSDRPSAKILIPVFAAVLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Q5</accession>
    <name>F9W3Q5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1090</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000452">
        <property type="protein sequence ID" value="CCD11778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27230"/>
    <dbReference type="OrthoDB" id="755305at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DIOX_N" evidence="1">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="19864" checksum="9030E8AC8405A3FA" modified="2011-10-19" version="1">MASDSVPIIDVGPLFQRKEGVMQVARQIDHACRTWGFFYVVGHPIPREQLERVMETAKRFFSLPLEEKLTVDIRKSKHHRGYGCLNAENLDPTKPFDSKETFNMGFHLPEDHPDVVAGRPLRGPNNHPTQVEGWVELMEGHYRDMQAFALVILRALALAIGLEENFSTQNSRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Q7</accession>
    <name>F9W3Q7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1092</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000454">
        <property type="protein sequence ID" value="CCD11780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27250"/>
    <dbReference type="OrthoDB" id="1686474at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389757" evidence="2">
        <location>
            <begin position="23"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="541" mass="59273" checksum="0124878414B45E05" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W400</accession>
    <name>F9W400_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1131</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000498">
        <property type="protein sequence ID" value="CCD11881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28200"/>
    <dbReference type="OrthoDB" id="1713663at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18791" checksum="86F3387A00B27322" modified="2011-10-19" version="1">MQSRDTRALETLYHQTLLTTGGCTLSYTRGGAHCTTIIFLKVVTDLKLQPPRVPGAVLSTFKIYMNRAFCECYSHIARHDCEMTYVHQSSDTLLSQSVEVDYAPIVMSVPEKCGVTFFQDMGSTEWCSVRMRCVRAFWLNHEIFAFVESSFLLPAINVFSNTTWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W495</accession>
    <name>F9W495_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1161</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000532">
        <property type="protein sequence ID" value="CCD11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29090"/>
    <dbReference type="OMA" id="WVRVMPR"/>
    <dbReference type="OrthoDB" id="845105at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="352" mass="38786" checksum="353D41B532E9910A" modified="2011-10-19" version="1">MIATLYRRVLKQLTLVKRVGACGMVHERCAEYLPDGHAAETGADLLSVTRKAFEAAKLSPASVTKGFGFLKELAETLPELEVLSLWKAYIARGDFDLLEGIAIASTALDVAGGTAAGVTPRVGACAATVQRTAEHLRRHVTEMKCALVQSGVTPQPPHGSGTATPQLQRVVSLLQERGYGVSEWAPEDHSSITFLRKKRASTVVMNAILALVLHELGLRCAVAGLDLYRPWVRIERPNKPMTFISLAHAGVCTAREVMVMHNSYQPSSLRLEVTPWSGKCRKELLAQMIHKQLALLSCRRFNEPLHERQQQLCRLQLEFLDLQGSHRVAPGPSRASTLNYSHRGELEMSERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P4</accession>
    <name>F9W4P4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1210</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_30510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000586">
        <property type="protein sequence ID" value="CCD12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30510"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="124" mass="13389" checksum="DDC8FD1E029756F0" modified="2011-10-19" version="1" fragment="single">MRSSVHITRALSLCCGRSASLLHLERGQKTLNALVIPLALCSTASQGISTSAGELDQGVGTSRDTVNGPHVPSSFCCPECGKHFIGAAKLLQHRRTRHKVVIMTSAQNGWNAWKKENVKLRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U4</accession>
    <name>F9W4U4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_30950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000606">
        <property type="protein sequence ID" value="CCD12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30950"/>
    <dbReference type="OMA" id="EDEYYEM"/>
    <dbReference type="OrthoDB" id="957254at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PTHR13832"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="107"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="47831" checksum="BACE6568520027CF" modified="2011-10-19" version="1">MKGFKTSRPSQRRSPAMSRATIIYSAAAFIIAIVISYVIGSEMGPISIVLTVVLLMYGVFNLARHILQILVINREEANYSNMLRRADVMQHPNIHKISNRGENEWLSYGFSCMQGWRRSMEDDHVTILTSDGGFFGVFDGHSGANVAKFCGDRMFEFVSETEAFKNKNYKQALYDGFIAIDQHLYSNYRGEKGGCTAVVLLVKGDKLYCGNAGDSRSILCRDAEAVPLSKDHKPFLPEEQTRIERAGGYVWNRRVNGALALSRAIGDFSFKSNTQVSWAQQAVTSAPEINCSDLDRSRDEFAVIACDGIWDVMTNEQVVNFVRPRIQSETPLDKVAEELIESCLSPQPFGLGCDNMSVVIVKFNRHPTLPTAEDVNPREDQVLHIDNDVACGAVEQSDLLLTAVSGPENGFSQRDGCDSSAENGFTVDDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4X6</accession>
    <name>F9W4X6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000627">
        <property type="protein sequence ID" value="CCD12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15205" checksum="2D3F062626B738D9" modified="2011-10-19" version="1">MVWKGFRCWRMAISHYFFPIRRRQTCIDLRQSMVSFIIPQNASLVKASDAARKAGRGRGAHTTPRGFWLGALRWQKNRYAALRQLRTSAWMGDIRVSEPREGVGTCEGCDCGEHETVRYHNGKTMGSNRKVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W503</accession>
    <name>F9W503_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein TCIL3000_8_3820</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_31500</name>
        <name evidence="4" type="ORF">TCIL3000_8_3820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000640">
        <property type="protein sequence ID" value="CCD12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_31500"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_8_3820"/>
    <dbReference type="OMA" id="QALMEFY"/>
    <dbReference type="OrthoDB" id="1274269at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCC92163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="21531" checksum="FFA6DAEB843A9859" modified="2011-10-19" version="1">MTTPATVPHPGGPKGSVNYVVEHAAPSAVCLVRKIQASPYQALPLDKVLAVTVPNLLSLRPPTHIAHQALMEFYAAMDGHCGVSCPDPSSVDLQLPASPTTNSSKERSPREPSGQIVSAACDGGTGQLQHGLPVGPLAATIQQSPVLSGAEDYRLSQIRRNERHVNNATYGRVCTFFLTREGCRRGRYCNFLHIGKGGGTALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5F0</accession>
    <name>F9W5F0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000708">
        <property type="protein sequence ID" value="CCD12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1744802at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14339" checksum="E736C58F797F0DFC" modified="2011-10-19" version="1">MQRELSDKCCRPSAPAGRAASQPFATKPVSESRSRAGPSQRDETSEATCPPPARQDERDLQGKLRDARSKYRRICAENERLKLALDDIAVLLTPRVRDGGSGGACGVPLGYNAALQELVASLQEVTDSMAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W637</accession>
    <name>F9W637_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1420</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_35010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000819">
        <property type="protein sequence ID" value="CCD12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="M17.014"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35010"/>
    <dbReference type="OMA" id="ICTSVQL"/>
    <dbReference type="OrthoDB" id="562530at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041417">
        <property type="entry name" value="NPEPL1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18295">
        <property type="entry name" value="Pdase_M17_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="520" mass="55485" checksum="279D2D7F3B5B2666" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
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    <name>F9W6B3_TRYCI</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35750"/>
    <dbReference type="OrthoDB" id="1688696at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29735" checksum="60ED54854A14B0F5" modified="2011-10-19" version="1">MTWLPISLKNAAKCDKWYQLQNHHIAQSLNANGAWEKLFRVIPVHATFSVSTNKKTTAALFFSLPLMMSRVCGVCAVCSRDVFESGVRRVYVPSSPINISCRQEGESPVCVLWCCYVRVRRVVCGMCVEVWSLWHEGCVWVSFLWGGVLLHFVPLETRPLSRFPSFPLRVIIAASFHPCSSGTPPLPPPVFTSKLFELKRQSGDVAWEEGFLPSSAVLTPHCGTGVCMSAHPQEFIYVYMLTDLSVAGPPAKLKHITQRRKRKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6B5</accession>
    <name>F9W6B5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_35770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        <lineage>
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            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000847">
        <property type="protein sequence ID" value="CCD12720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35770"/>
    <dbReference type="OrthoDB" id="1655821at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="584"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="726" mass="76199" checksum="75166401248B74A4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6D1</accession>
    <name>F9W6D1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 144</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_03590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000850">
        <property type="protein sequence ID" value="CCD12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03590"/>
    <dbReference type="OMA" id="WKENVAG"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19762" checksum="0B04A2A1C16AB315" modified="2011-10-19" version="1">MYAKRYEVGSAGEVTRRQPCTALLSTPYIVLYRDCEVSCWAPVVSPDSDRFWITFDIIVGVGTEVIAPSKPARALHAWNKARWDEFRPISDKLISHRTKRSVKGVGALDEAVTRGIRQASKRKRRKGKGVVPPFWILELTKLDVMVQQCRNERKRDALIRWRRKVLADTAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W743</accession>
    <name>F9W743_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1564</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000979">
        <property type="protein sequence ID" value="CCD13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38200"/>
    <dbReference type="OMA" id="LCVSMCM"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1113" mass="136955" checksum="9864EEBCBB4C0A69" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B0</accession>
    <name>F9W7B0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_04000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04000"/>
    <dbReference type="OrthoDB" id="1709027at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21232" checksum="E6BDA299F58B7607" modified="2011-10-19" version="1">MSWYTITSTRTIPWSMEKDVVEVLLDGVASPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEANVCDSLWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPYQGVVLVEATTALIQVPYPAVGYLVPIPLSSQPWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7I8</accession>
    <name>F9W7I8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001041">
        <property type="protein sequence ID" value="CCD13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39340"/>
    <dbReference type="OrthoDB" id="1667113at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388767" evidence="4">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="21"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="90"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="388" mass="43401" checksum="5FD3793F31576A70" modified="2011-10-19" version="1">MVCFMNGIVVLIFNLPRSFVSSQTQVGRDDNIEPFSLLCRIYNVAKNPPINYVNLQQSNKVVEEIDALNRSLLEEKRLDEKEDAGNNSEAHVKPTVTREEALTQLSLNQITQKANTILEEIEKMNVTKNIENTKAEFHKVIFGENGSESELCQATVKGMDNRSEVCGKPGAQEKGSHAGNNLVVDFFCLCAQRTDEEGANQVCGFYVGRISQYYGWDEKNGPWGSSTMWASIKGGCGKHMYRRPKSTAEARHILDQFLKHLKTCGVYRWGSGKVEISEINEGMLGKGVQKKGSSREERSICDRKKEKSGNLGGVCVYYGQEPHSWEANIAWLKVFKTSLTGVDAVNNKTATLQRALQKLQMLHQSSGEIYETAKVISEIQKPKKHADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S8</accession>
    <name>F9W7S8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1651</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_40190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001076">
        <property type="protein sequence ID" value="CCD13250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40190"/>
    <dbReference type="OMA" id="ENNDWID"/>
    <dbReference type="OrthoDB" id="288077at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="208" mass="22120" checksum="95804594B4D5E4F1" modified="2011-10-19" version="1">MTKDCHLLGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAEEKGTGKRNQIVITNDKGRLSKAEIERMVNDAAKYEAEDKAQRERIDAKNGLENYAFSMKNTINDPNVAGKIDESDKSTISKAVEDALQWLNNNQEASLDEYTHRQKELEGICTPIMTKMYQSMGGGDAAGGMPGGMPGGMPGGMPGGMPGGMGGGSSGPRVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Z1</accession>
    <name>F9W7Z1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_40800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001106">
        <property type="protein sequence ID" value="CCD13314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40800"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389926" evidence="6">
        <location>
            <begin position="24"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="46"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39466" checksum="30C73177ED3D6326" modified="2011-10-19" version="1">MRGYVVALLLVCWCLLDIRNVNAINEDVYYKLCNITKTVTGLLKYKVENDALREAIYGSSDGALFGEDGGLKGGKCGYGKMRSQLCIVSNRHTLGIGKDGCYAESLFGSFYCLCTPGSNKENVGTLCGRNVQVYRNKGWWHEWHSSMNVEDLFDDVWKNVIKQCSGVSQNNQDMKDKLENLKRALMNLNESFGKSENGLFYYGGNRGTFCNGITQGDACLGYPRASKDNVSIPWMKKIEDAIEKLENTEQYSLKAADQSPTAGSAPSAYIDSGEDVSEGKYKKPTSQLPSAAENISDQKGNGESQPQSIGNNGDSSASRPRNKRSTEGSTIINVASLSSEGSDDGTLLTSPKGLLWITLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W843</accession>
    <name>F9W843_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_41270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the COG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001134">
        <property type="protein sequence ID" value="CCD13370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41270"/>
    <dbReference type="OrthoDB" id="922484at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="PTHR31658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="451" mass="49499" checksum="C7E6793C4B6DC52B" modified="2011-10-19" version="1" fragment="single">MSSEEAVQEVRRIFTNNSVEQACEYLDRITPGIQESDERLKQLVGQSYRGLIAACDQVVVVEQTCRKLLLLHKQLQKQHGRRQSPVRPGSRGNLSSFATSSPRGGEGVHKKECGHFDEPVLVTTTWPSSGTELGAAALRDTPMAGVDEAAEPGGNNRNERLVHTREAMSSSGEAERQRASQHEELSLTHQCTALEGLLGTWRLRRAAALFLHIRDKWDKRVKGFNVDCYEIRIRQTICGLLRNDADQAAVQAITETVSNESNRAPLPINAAGTSDEAKEVRSGAFANTFIPISNTSSTSNSVRRKWNSSQAVSHMMEVHATLELLSGTTPRTALLLLIDVVGNMVKTDMDFVTSSCKENPFTQPLLVDFNSSGGSGLPPLRRMEWLRAVVQLPPHLQCGADAPNLPDTAATCVEGDVTKCCVRSAVSDAEVALHIVQRAQHLFYHLVLYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W892</accession>
    <name>F9W892_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41730"/>
    <dbReference type="OrthoDB" id="1710740at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="21198" checksum="6680EAEBEFD237FF" modified="2011-10-19" version="1">MSLYTITSPRTIPWSMEKDVVDVPLEGVASPDHVNLYWFLRPVLDCLPVDLVCFTLGDFVRNPRHCIPEANVCDALWQYLPYLLRKFRLSATSLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPLPQYQPYQGVVLVEATPALIQVPYPAVGYLVPIPTTSQPWPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B3</accession>
    <name>F9W8B3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_41940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001158">
        <property type="protein sequence ID" value="CCD13445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41940"/>
    <dbReference type="OMA" id="TGIAWKE"/>
    <dbReference type="OrthoDB" id="889671at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033036">
        <property type="term" value="P:macromolecule localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="PTHR10926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43489" checksum="F4A5EA3F203B2875" modified="2011-10-19" version="1">MGFVKLLIQQRLPAWQVNLTAPAVSIAFCVVAILCAALGSLVHLANVKVVEISRRYDNKFCKDILSKKAVNDSGWVNVSKGCVAEIEFLVDEELQQPVFLYYGLTQMYQNHRRYRNSRSDAQLMGANPRSIPDADPLAIPGDINGLKHASIEYSGEQRHYSDFVYVPAGLVAWSMFNDSFTLYKRSDSGNGSENELICNGTDFSRSTNLPLGWSSNNKCHKKGIAWSTDVAKRFVKPNWNSEDLIWTAPRTEYGESSSPTTNDTCWNNGWYAGEPGHLIPVTTDEDLMVWMRTSPRPTLRKLYRVIDTTLTKGRYVMIIHDRYNVASFGGEKSFILTSTSFLGGKLTWLSFTYFAVSGLAVLFSIFIPLSSWLCSHRSRRTVKVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8M4</accession>
    <name>F9W8M4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1748</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001184">
        <property type="protein sequence ID" value="CCD13558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43000"/>
    <dbReference type="OMA" id="FRWPEAP"/>
    <dbReference type="OrthoDB" id="444029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="407" mass="45391" checksum="579D3C19AFA4093A" modified="2011-10-19" version="1">MLRKRYRPLDTAEERSVGVEQSLHVGLLHDEQSYCFRWPEAPLTSMLRRSDPSLALGMQSGTNLTAQPPVVLPQTPKLSHVATEHGKIDLFNSFSLVNPAISFSSLSNPPTVNDVVLQRAKRHNAAPPTASVDDNIFTFSATQLKELELSGVFDAFREAYYVSSASTKIPEDELIKRTAIMKMEEEIVNLEWRASQEAEKTSPAIKRILQLTVAVPFKGSIEGVGDSVEQVELKWKRALYDLWIKWRIEPMGTMEPSGQSNSSLWGFPLMPGFVTPESSKEYFMNVATSTTNAVRGTKVSDNIGSGFGRETSLSSAPGRRGAYGYLRWRIDLYEPRLRAVSEGANEHRLSGPSGLMGVEDVKRLIENKLPSALSDVRLCGRVDPLDAFALEDIRTDVVTWRQWLAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R0</accession>
    <name>F9W8R0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1763</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001201">
        <property type="protein sequence ID" value="CCD13596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43350"/>
    <dbReference type="OMA" id="GASEMCA"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="312" mass="35624" checksum="BE015731725671CB" modified="2011-10-19" version="1">MIGPLPRYVLADDPTYEERVEEVDGALALMRDDVGYYMDVLDNRDEWRKDGTTHKLVKLVCRKVKRKLVRRNQVTSLYVRAELLEKLHAARLRKSLIYYVLRGASEMCAGLLEELGLDAFMLQEAVDALVKYLKHLPHVSGETRESVLCQGDAEGRVPTTLSEFASDGPKRELATGRLYKPLIPNFPLVDGFFVVEGKGPKTIVLLQITKAKEHHTKRTTVRQFRDYMGKVFEDWENIEGSCSWEIIYVQHVDSTAIKKRQQCASSRYAANDTDLALWDRIHQYQVTLNSDIASEFISRSSDPREVQSASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R3</accession>
    <name>F9W8R3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1766</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_43380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001204">
        <property type="protein sequence ID" value="CCD13599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43380"/>
    <dbReference type="OMA" id="HINIFYI"/>
    <dbReference type="OrthoDB" id="231263at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="PTHR11226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394614" evidence="1">
        <location>
            <begin position="30"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin_12" evidence="2">
        <location>
            <begin position="71"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin_13" evidence="3">
        <location>
            <begin position="352"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin_14" evidence="4">
        <location>
            <begin position="503"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="589" mass="64617" checksum="0CCE722A0CB8E580" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8Y5</accession>
    <name>F9W8Y5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1799</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_44070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001240">
        <property type="protein sequence ID" value="CCD13671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44070"/>
    <dbReference type="OrthoDB" id="1713667at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18588" checksum="A1264CF066E162F2" modified="2011-10-19" version="1">MASNPPSDTFLSEEVRLPRCPTRPCYRHIEELGFTPRNAATRIVAKQNRLAHHCGAHAASLPKSKRAQPPRFTTRPSAFNRQRGGGKRHEACSLPTATIRLQRYVTHECLNSYIGGVFAFVARRTLHNGWSTSPCTFRSSGCSFSVQRLAQISYITSSRAGGMELSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W906</accession>
    <name>F9W906_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_44290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001250">
        <property type="protein sequence ID" value="CCD13695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44290"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="117"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="426" mass="48497" checksum="FD56B5FEB5DBF6BD" modified="2011-10-19" version="1" fragment="single">MPHGMSSTPTGLGWKFCSFHALILDALEMFHGSLLVTGLLAYIAMLAASDMENEHEKLIFCLIRLMAEREPKELVFRNSVEESEIVSRIKQLNSSVMNFHRMKVGGSERRYVDKRSKEYGREIHKILEAALHLKAEADAYKFQAAAKRDSARANLKRVIYGDAMNFTAEDTDIQRRIDDNTSKENVFQSIRKPEESCSGPGAGRSLINDYFCLCFTKNHFGSNEKSYRGVCGDGIVETSWDDTKEGWLAKWHKNKDKGCERFQGRLPSPPLIEEALYLFNKTVVAIHAKYHEKGVFGHYQPRDRDNNPVPCMSTTYSNACVDYNHALNHGGIPWVNRLQNASEDLREMEDLVSKSESILTRLELLEHDAEQIYVEAKFSLHLPEKNDLDSLMEEENALDDTEPNSSLDDAETSYSGRRNFHVIGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W922</accession>
    <name>F9W922_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_04680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001254">
        <property type="protein sequence ID" value="CCD13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13451" checksum="AF822D8649C106AE" modified="2011-10-19" version="1">MQSDPQSAVDRIKKHVAKPEELREAARERQSLLGSLDPAKFEKSRMHEVVRILQSIICRKLGNRNLNAEVQKIVKNLKMVKERPQSFVCTLRYVNRGNNTASQLASLKRIPTPQGNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W944</accession>
    <name>F9W944_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1814</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_44420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001258">
        <property type="protein sequence ID" value="CCD13734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44420"/>
    <dbReference type="OrthoDB" id="1713345at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="29260" checksum="E66A921EB4E450CB" modified="2011-10-19" version="1">MYAMFLQIPFLDLRKGLANKRFMTALLTANFVAIPLLVWALTMGLADHPAILVGALLVLLTPCIDYVVVFTHIGKGDSKLTLAATPLLLVLQLVLLPLYLAFMVSDDSAVVISVGPFVEAFVVLIALPLVLAVATAAGAKGSRIVEGWNNVWAWMPVPAMAAVLVVVIGSQISTVVRDMDKLLPVIPVYIGFMLLAPVVGALVARAFKLPASTARSVAFSSSTRNSLVVLPLALALPEEIRGLAAAAVITQTLIELVSELIYIRAIPALVWRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W985</accession>
    <name>F9W985_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1832</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_44770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001278">
        <property type="protein sequence ID" value="CCD13776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44770"/>
    <dbReference type="OrthoDB" id="1719813at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17849" checksum="256C1727A23A9BB0" modified="2011-10-19" version="1">MADDKRELSATAGNTPASNWRKMRRVQLFLYRYFRDTCQTTLKCAPNRKNIFGKIEVVNSITATNARGSQTRQDRFVPCGREFLPLKKKNAGRGPENCGGEPKRREDFARTRGALSARAGGAVVQELRQQQEPVTVLAVCIRYAKLIKQEWGNGEVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9G1</accession>
    <name>F9W9G1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1856</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_45520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001304">
        <property type="protein sequence ID" value="CCD13861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45520"/>
    <dbReference type="OMA" id="AREHISH"/>
    <dbReference type="OrthoDB" id="1668952at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394624" evidence="3">
        <location>
            <begin position="23"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD13861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="514" mass="57497" checksum="2E09F3DA8F40FE7A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9I8</accession>
    <name>F9W9I8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001319">
        <property type="protein sequence ID" value="CCD13890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="109" mass="12865" checksum="7AD2866AE221B632" modified="2011-10-19" version="1">MRTRERRSSCLTRIENAALSLTLIFFPFVRIDNDQGEKMVWYFSDETQPVEGRHLLTRGAWTAGRKSGKRKERQEHAPLKDLISAAWCLRKHLSLEAKRNFTQMRKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9J3</accession>
    <name>F9W9J3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1870</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001319">
        <property type="protein sequence ID" value="CCD13895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45850"/>
    <dbReference type="OrthoDB" id="1717074at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19319" checksum="0392E86A7BBAF12F" modified="2011-10-19" version="1">MLHYKPEWLKVVAYFVKGKAYLFHREEKRVVSHRKQQVAVDEIEGMIRRGVKGYIIFDMGGSDAIIDHLPRSWGIVLISSPSVSKFHDFTTQRYRTLPIYMNCYEDAEFKAALVWERHSQGKKQVEKENVDAADDREVLKERIDMIGPLPRYALADKVTYEKRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9V1</accession>
    <name>F9W9V1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1900</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001352">
        <property type="protein sequence ID" value="CCD14006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46890"/>
    <dbReference type="OrthoDB" id="1713668at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18174" checksum="AB45606AE26AFFFB" modified="2011-10-19" version="1">MQRHLCSEALHTVLYTFEPCSLDPCFRRFVSCSSHRLLRTPPSPYPFLFPHFVPRSLNGHCLPCHFHFATGGAISHGAPGENVSSLGIQAELILFLCARRSIFRSFVIIVNTLPRMAPLPSQPPLPFILPHHASGTATPHHPPVVLLPGGVSIAAVLPAFAECALCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9Y1</accession>
    <name>F9W9Y1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1910</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_47160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001363">
        <property type="protein sequence ID" value="CCD14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47160"/>
    <dbReference type="OMA" id="MLVITEM"/>
    <dbReference type="OrthoDB" id="583605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040643">
        <property type="entry name" value="MLVIN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18697">
        <property type="entry name" value="MLVIN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="295" mass="32715" checksum="B5D1D653A3444C76" modified="2011-10-19" version="1">MYGNKYLLVFVDTFSGWVEAFPTKTETAQIVAKKILEEILPRFGIPKVIGSDNGPAFVAQVSQGLATQLGIDWKLHCAYRPQSSGQVERMKRTLKETLTKLAIETSRKDWVALLPLVLFRARNTPGCFGLTPFEVLYGGPPPLMEAGGTLVSDSDPVLPSSLLIHLKALEVIRTQIWDQLKAAYTPGTTAVPHGFRVGDKVLVRRHRTSSLEPRWKGPYLVLLTTPTAVKVDGIASWIHASHVKRAASQDEENHKDNWTVAATDNPLKLRLRRRRHPEPREPQPSCSNSTVLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA15</accession>
    <name>F9WA15_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1919</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_47380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001374">
        <property type="protein sequence ID" value="CCD14070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="769808at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="528"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="938" mass="103367" checksum="817D57DF1249EEE6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA87</accession>
    <name>F9WA87_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001407">
        <property type="protein sequence ID" value="CCD14143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14493" checksum="9593CBE04DD88C40" modified="2011-10-19" version="1">MSHTSTNPEWVGSNELESALAPLSQNTPSPVPYTQSTQRHVDPSTSPVRERSENTYAMGDALGEEMLYYSESERVRIWQSEGLEQNAKDKRLTQLSAEYSDATEMIRTSHDGYPGRLLRNARNAKTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC2</accession>
    <name>F9WAC2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001413">
        <property type="protein sequence ID" value="CCD14183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48310"/>
    <dbReference type="OrthoDB" id="1709028at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21300" checksum="597C9C48C3E29313" modified="2011-10-19" version="1">MSWYTVTSTRTIPWSMERDVVEVLLDGVTSADSINLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPYQEVVLVEAAPAFIQVPYPAVGYLVPIPVSPGDWRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAF6</accession>
    <name>F9WAF6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_48650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001428">
        <property type="protein sequence ID" value="CCD14218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="13661" checksum="2B76A85B0E09703E" modified="2011-10-19" version="1">MGRFLYPERLCHIGQMRDFGRKRARVLGLYFSLILLYILVICAYVVSFTSVSCFPSHTDTPTCICDMISREAGVSPTGYDNLPCGVASLPSPITGCRRRDCQVTDCAISGETVCPPLLSFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAN4</accession>
    <name>F9WAN4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1996</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001459">
        <property type="protein sequence ID" value="CCD14305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49390"/>
    <dbReference type="OMA" id="CLAKKMA"/>
    <dbReference type="OrthoDB" id="1654482at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="824" mass="92893" checksum="15E0F1636C317405" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAS1</accession>
    <name>F9WAS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_05350</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001476">
        <property type="protein sequence ID" value="CCD14342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05350"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="4">
        <location>
            <begin position="56"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD14342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="281" mass="30892" checksum="D4636DD6C479FF9A" modified="2011-10-19" version="1">MKVLSWLMVRMSNLSLVLVLGVLSMGMGMILGMSVWSGYNENAFSTLCAVLKSSERLLNTNTISEPLKSEMEYALYGRPGGVLTVENGKVSVKANRDSPINRSELCTYYNGGYGCFAESLAGTLLCTCTPGEGGKDFCGLGTLQNADPWSGGSTPLERKQDLFQSLWDQVRNKCPYGTEHEKGTREDDVGHLEKAVQRVRDTLKQALPFFYLGGRPGRRVPCSGSDPRNVCAAYYTCGWPRQNVHIPWLDTIQQALEDLKDVSQTVSVPSTPTDGRDTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAV6</accession>
    <name>F9WAV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001488">
        <property type="protein sequence ID" value="CCD14378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05380"/>
    <dbReference type="OMA" id="KMVWRAS"/>
    <dbReference type="OrthoDB" id="1176388at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="339"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="398" mass="45785" checksum="A97D5C46BA5ABD4A" modified="2011-10-19" version="1">MEREELAKEFLKVEEECRQLRADVAILERARRYQSMDISSLALTPDQARSLSRNVKGRSIFIPMETVGEVNSKAGELHLLVKERQRLLRERSHLEEALNDATLQTTKAEEEHNEIKNLIGLTGHETLAYVKDMENAIATKNMLKSDIANALQDRETIQETLKKQNAFLNKMLTELATTDNIENDRANALTQLSEKQAELKSIRDEIYAMKRLLRRKEALLEKEKPVDEMALVKSAETERSVALYKLEKERDAVRINEHSVAHRAAQIARLERRIEMIGDAVGGEESMDDERVDADLVEQVRKEIISLTRLHFDGSAQLELLDSDIADLDRRAAGLCRTTANVRKEMKRIEKEHKKYANAQRKELEMEQMATEHEIKEIEREVEALRQVSVRNGRVRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAY8</accession>
    <name>F9WAY8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2034</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_50300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001502">
        <property type="protein sequence ID" value="CCD14414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50300"/>
    <dbReference type="OMA" id="ISQNTHR"/>
    <dbReference type="OrthoDB" id="1656501at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="794" mass="87760" checksum="4C96765EC4E25752" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB40</accession>
    <name>F9WB40_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2057</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001527">
        <property type="protein sequence ID" value="CCD14471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50810"/>
    <dbReference type="OMA" id="NMRNASV"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="644" mass="66276" checksum="34D95293C78C4E48" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBC1</accession>
    <name>F9WBC1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_51590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001562">
        <property type="protein sequence ID" value="CCD14552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51590"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20144" checksum="D01F423038C27855" modified="2011-10-19" version="1">MSNSPSSPSPEGIAQDNTPWSMEKDVVEVLLKNLGDPKKINLYRFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREKVWQEFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBF4</accession>
    <name>F9WBF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2099</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_51900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001573">
        <property type="protein sequence ID" value="CCD14586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51900"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="786" mass="87052" checksum="21F3223F14529C95" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH6</accession>
    <name>F9WBH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52130"/>
    <dbReference type="OrthoDB" id="1699157at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22361" checksum="FACD1C1ADE040446" modified="2011-10-19" version="1">MPMKAQFPRETHERIIHSPCTQHIAGIGNSSAVILPSALVCCFSSILRSTVHAATPHSSQPPFNRIGRSSSHTATQTALTAYFHFTENYSTPSSNEHTHTSAQVSPNDTHSKHHPLIPKARLQAAHQRHVRPHKHAGIICNPGSKSYALMLEIMKLTSNAYLNIPTRLPHAEVRNLNAGNNCCILSVSITCLECSDAHGAGQWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBJ8</accession>
    <name>F9WBJ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001589">
        <property type="protein sequence ID" value="CCD14631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52310"/>
    <dbReference type="OMA" id="NTYCDDP"/>
    <dbReference type="OrthoDB" id="1097342at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="469" mass="51977" checksum="D313E77FDC004CB9" modified="2011-10-19" version="1">MDAQTDSKTLQFATVTVFQDNAEDVTLRVPLEKDITVRQLAKKVIGRLRIRSGVNNQLPDKFHVVGIFVKSESGRAEIFSCDMVTQVVKVNEEVIFMQLQAKDEGKDGNVDPERHIASSTEEIYSAGGTHRGEQQRAKVCDRLNDESYSGYSDKRATTRRSGAAPVVKGKRNAESVCSGSDDAVERRNCRMRSEKSSKVVAKKPSGALEAEKNLSSRKDTNTRGGKATRSIREEVTKKQVVRGSDGKKLPGTGSASKETREERARRRRGDDVATIPEMKTYLYWGPEASKNFAPNFTNSPDKIGRILRKAKQSTRADKEVDEAGNRRSGTVQTTVLSNDMEEPRTFPAAVNGSRAKANADDTQGKCADNPIDVERQLLFDVDEVPQTPLNQCIRSSTEATGDRDAEHRAHPRKECESWGKVAYDYFDPETYCDNPAKAKLSPAALSMPLCTRSAHLSSQRVMEQPLTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBM2</accession>
    <name>F9WBM2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_52540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001598">
        <property type="protein sequence ID" value="CCD14655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52540"/>
    <dbReference type="OrthoDB" id="1672830at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="65"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="360" mass="40354" checksum="95F0A707DCEC5A1D" modified="2011-10-19" version="1">MFGKMMMLKSIKVMVMVGLVVIGIHADVHVILNSSHFDLLCNVTRATTGLYLAFVEYDELIDLGKMNELGEKINKIFFGSKWSGRGGGIWKLPETFAEKNPKRSEICESTSKYEDVPLPNDSMATTFFCLCTPTSVGKNDLCELKVESKDIWSDTAKDVKKVFAELWGDGFDANVMNKCGSSNTGGDFEVEKNHLTENLNKLKSIFKKSDILGISRITCDESHACARITKNPTWMQKLEEIERLNLTQIRLDAIKQELESKQKIVDESTSSASEYISASQPSPIAESAAEGFHIPEETPKPKTRRAPEEEKKTEQERVSAKIPQNKIEKTEDPIPTPEQNEASGSFIIRQKWLLLAALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBR4</accession>
    <name>F9WBR4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001617">
        <property type="protein sequence ID" value="CCD14698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52920"/>
    <dbReference type="OrthoDB" id="1268130at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="402" mass="43899" checksum="B414F55184FE0176" modified="2011-10-19" version="1">MQSTKAKVTKQEQHNVPVTLSTSSSASVYLTTITNRIAARHGVSFLILKPVEYTGQTKEPQESIKNSMKGAIAKGSTNNPQAMEKFKQSAEMWSAMWAQPSGSVGSQVQTQHRVRPILPASLLLLFSDMGMSKPYEPLGLLGLLKPEDEVVSRCFRGAEARQSPLQPVICIYLNALESIIEVTDRLSAQAKAMYCQIYRENALKRGTDVANHGGNSTKSADNSPEKCRSRFFLLTPSAPYAALRETANRIVNDEDTGLTGTSLGLGEAGEILLVYDLNHSSHSFARDHSPECNPEVWGHVNYQQKRSGNSSGDAHERDELFFIAQTLEDYFRLGSTFSWVYGWQLCYASQGPPARSLSWLKLFSPNALAAVVTLNALGSGSKSTAADKTSAITPDADTRTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBZ2</accession>
    <name>F9WBZ2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001645">
        <property type="protein sequence ID" value="CCD14779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="15064" checksum="368709704ACA3693" modified="2011-10-19" version="1">MAFVLEWRKCRCIKLRCRPAPRHHSQLRRVRASRLFFLGVCGNLLALRQNKAVGREIQTHATRTVTGEHSRGQSAAIAVVWRIFFLCFIYTCSLACFRAAACSHKRQLNEKDEQALCDFLKITSVRIITKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC52</accession>
    <name>F9WC52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001671">
        <property type="protein sequence ID" value="CCD14844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13834" checksum="311EB975187F94DD" modified="2011-10-19" version="1">MLFRVIFSFPSPGALQNCFCNNYFMLFRVIFSFPSPGALQNCFCNNYFVSFLVFRHPARCKTVFATIISCFSVSFLVFRHLARCKTVFATIISCFSVSFLVFRHLARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC76</accession>
    <name>F9WC76_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_54420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001678">
        <property type="protein sequence ID" value="CCD14868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54420"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390141" evidence="5">
        <location>
            <begin position="19"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="186"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="355" mass="39787" checksum="2F1D28ECB0D45375" modified="2011-10-19" version="1">MKMWRVVIVLIGAGAKSAITNHNGEHHATLCELLRAATRLWNATREHLHKDLQDALKHVIFGEVSEASAVNFTLPDAYGNSREKRRNWCGTRSPIENLWPGYSAPYDLVCLFTIGMRLAPFLERNLADTLCGAYRADLGCGRSRLGGRIWNERRGYGYQPNFLLATWTNVEVTARGEMLLPLTKVTLSKKWKIKQKLQKFTEILTTTGGFSGGTKYILGGSNFNNYQCSGERAEHACVEYPYCCRVFDKKLVHKNQTSWWKRLNKTLKRTTSELIVRATTIQSSSENPQSSTESSTSSPQDTNVPKPRTSRSTPGDPSETNTTESNPTAQPGRLNITSSMPITPLRSWLLAALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC85</accession>
    <name>F9WC85_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001682">
        <property type="protein sequence ID" value="CCD14878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16841" checksum="2DB471D87B1B7D5F" modified="2011-10-19" version="1">MMDVGGDGKYEVERNNDVDEDEIGVWKEECNSETHLLLLLLLLICCVALLSIFSFSLRRRLTFPLSSHGDRWQIRDFHCFLFFELAPSPYLPPPFCRICVGCLFCFILSTATPMVITTGMIEAAVTLNCYGERMLTLRPMSWEGNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE8</accession>
    <name>F9WCE8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 2220</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_55090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001708">
        <property type="protein sequence ID" value="CCD14941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55090"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="1292821at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBQ-conjugat_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="SSF54495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="58"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="24281" checksum="2EB4D55CDBF19765" modified="2011-10-19" version="1">MDQVTQPGVGVVVVPDLAAPEDLEVNVVLENERQSEDMRAALAGGAHARGVNPQNAEDAKRRLMRDLKQLHTNKNERFWARPESDNLFKWKAVVLGPEDTIWEGGVFKLWLEFSDEYPCAPPSAHFVTKMFHPNVYVNGDICLDTLKSNWSPTLDVESVLLMITSLLSDPNPSSAANGEAAKMFAHNRDKYEERVRRLVEESLEQAFSDEDDGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCF0</accession>
    <name>F9WCF0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001709">
        <property type="protein sequence ID" value="CCD14943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55110"/>
    <dbReference type="OMA" id="PYMHYVE"/>
    <dbReference type="OrthoDB" id="899076at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106370">
        <property type="term" value="F:protein-L-histidine N-pros-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007884">
        <property type="entry name" value="METL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12890">
        <property type="entry name" value="PTHR12890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05219">
        <property type="entry name" value="DREV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="300" mass="33626" checksum="3482DB70853084A6" modified="2011-10-19" version="1">MFSAMMRDMEKYKKGARRRPPISYRADIAALPEHIVGSYIPMDMDNETRTWLEAAADVSALGILLVGLLRHFVSLTTANGIVGRGGMFVMSTIQAAQLLLGVSRAAAEVRLKQEAAPMFGRLLDIGAGDGGVTSRLQPLFQHVTVTECSMPMRWRLWRRGYEVLSYQDPFTMEDGSRRYYDVISCLNVLDRTDAPLDLLTSMRDSLVSEGLLLLAVVLPWCPFVEHGTEKRPPSQLLPMEGGECCKGASFEQSLERLVHNVLNPCGFQLQRWCKLPYFSEGNLKVEYAVLYDAVMVLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCF2</accession>
    <name>F9WCF2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2222</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_55130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001711">
        <property type="protein sequence ID" value="CCD14945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55130"/>
    <dbReference type="OrthoDB" id="1657175at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="1">
        <location>
            <begin position="103"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="637" mass="71041" checksum="DA50FB807386EF08" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCP2</accession>
    <name>F9WCP2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_56030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001747">
        <property type="protein sequence ID" value="CCD15037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56030"/>
    <dbReference type="OrthoDB" id="1712528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21631" checksum="2041E8B59D80C819" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQTETPWSMEKDVVDVLLEGVTYADRINLYWFLRPVLACLPVDLVCFTLRDFVRNPRHCIPAANVCDALWQYLPYVLWKFRLSATPLVKHFGPTQTWNEWHWDSWKIYFDNDDMPLEAIDEEIWRRCRRPPPPPYQPCQEVVVVEAAPAFIQVPYPAVRYLVPMPVSPGSRPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCS3</accession>
    <name>F9WCS3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001753">
        <property type="protein sequence ID" value="CCD15071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="15335" checksum="AE2BBBDA6583EE04" modified="2011-10-19" version="1">MAEGTQAAKEERLHQSRKGPIKRKGNNLQHQIQELIFHHEGNKRTYSQVLQKTCRSLPQQPCVDRLQTPKGKGDSRPRRYQRCRRRAGRHFALPSSSLFFPFHLNVLTSTAHKQQSLNCRISLLIFYMPANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCV9</accession>
    <name>F9WCV9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2282</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_56670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001778">
        <property type="protein sequence ID" value="CCD15107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_56670"/>
    <dbReference type="OrthoDB" id="1362434at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029157">
        <property type="entry name" value="CEP44_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15007">
        <property type="entry name" value="CEP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP44" evidence="1">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="195" mass="22213" checksum="469D1CEB6A705816" modified="2011-10-19" version="1">MHLLPYFYSEYSLRMLGDAITVNKIVFSILQQKLHAVGFDAWDTISEADVYSGHPHCYALFMRSILYGFPDVAAALLRKYPWFCIGGGDEALASSVFRILFQEYGYKPKINTLQFRAKKFAHLKANICLDMFDLLKQSIPRGGYGRGKTNYKAGRNSSLPQYASRGTMDDVGKLLDLRLSNLENRRRTLNHTVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD56</accession>
    <name>F9WD56_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_57510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001824">
        <property type="protein sequence ID" value="CCD15207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="104" mass="12823" checksum="6B0A29D01D3A0110" modified="2011-10-19" version="1">MLQYRRVALPPSETIWRRIWRWPTKTFTLRFIMLWPIYFYFFKQRKFSFLPSPSGFVLVCEWLLSPLLFPPSSRGLAIYDRYYYCYYSRGPLLSISGLWQMKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ6</accession>
    <name>F9WDQ6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_59370</name>
        <name evidence="6" type="ORF">TCIL3000_11_15610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC96051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001897">
        <property type="protein sequence ID" value="CCD15410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.15610"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59370"/>
    <dbReference type="OMA" id="DVAIFRF"/>
    <dbReference type="OrthoDB" id="1311668at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="PTHR19370"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCC96051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="308" mass="34129" checksum="00342E9FF482FAF4" modified="2011-10-19" version="1">MKFIAFAAASFFGAAVKSHISSLQLPAECHTSSVFDSKFRQFRLGEVINLAEDVAIFRFLLPNVDDTFDLVPCSTLQGCVKEGVNIVDQPMRFYTPITPNGVKGYFDILVKKQPRGRFTEHLFAMNVGENLLFRVVQYKLQYKKNRWSEVGLIGGGTGICPLLQFMNASFNMPGDTTKMALLFANRSENKILLKGMLDDAAKKYSNRFKVHYTVDMIENPENNYDGFVGYITPQMVRETMPEAAGNNIILVCGPDPMMTKVVGSSPGVLKAMSSGQAYQPTGTVLNNAPDVGGILGELGYTKDHVYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ8</accession>
    <name>F9WDQ8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2391</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001898">
        <property type="protein sequence ID" value="CCD15412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59390"/>
    <dbReference type="OMA" id="QANERTW"/>
    <dbReference type="OrthoDB" id="1559479at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="209" mass="22395" checksum="8192913077F11B7E" modified="2011-10-19" version="1">MGDCDNEYREATNPIEAFIDCARYDEPGDADEVRTLLSGSPSFVNVQDEQGRTALHAAAANGRMDMLEILLSYGPTPDATNNEGNTALHFAALNNQVEAARLLLKNGWRASARNTYDKTPIQLIYGKQFEEMELLLLGFDEELDNLPATVSEAAGCADNVETSAASQQVPQAAGQGAGEFRTHEEVSTVADSEGSPAKLLGSVGVDEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDV6</accession>
    <name>F9WDV6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001917">
        <property type="protein sequence ID" value="CCD15461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59810"/>
    <dbReference type="OrthoDB" id="1695191at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="217" mass="25357" checksum="4E772FAB7FF0A97A" modified="2011-10-19" version="1">MQQNSSTIRQTFNPSAVYLYDHSFFSPILAFSIEIPMSFYTITSTRTIPWSMEKDVVDVLLEGVASPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEANVCDAVWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPPPYQPYQGVVWVDPAPAFIQVPYSTVGYLVPIPLSPGDWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE32</accession>
    <name>F9WE32_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 243</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_06350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001944">
        <property type="protein sequence ID" value="CCD15538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06350"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="252" mass="28563" checksum="5B14159D3114C27B" modified="2011-10-19" version="1">MRAAAKAHDTEAPGKATKERRNHGDAHASPDSDGEPVQEEQKFVCQKCDRVLKSRTWLTRHKCTPSSNPNSENSTVAEQSDTAACTTCSKQYHYKWLLRQIMEKHTGHDESLRPQPRAKPKRKTMRSEAPAQGGGGWTVESVGGGDGERERPRKRPRMGRHKEGEEERDYVCGRCDSAYRQWYSLVWHTPTHHGHAATVKGKMKDGTVAVTPLLQRSIQCPYRPVKCDLKQHLTMHLQAKHGQRKKEAEHTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WED3</accession>
    <name>F9WED3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 250</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001993">
        <property type="protein sequence ID" value="CCD15640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06590"/>
    <dbReference type="OrthoDB" id="1691955at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="271" mass="30625" checksum="3A78015EE05408D4" modified="2011-10-19" version="1">MVPRCAHRQTLHTTWRSGITQRHIWGLIRRGDLSFAKDQRPAIPNDLEVESSTPQTSMAQCYCCAAWGHHRSACRGPQEVNHGTRRAGASAGGWVVVGIGKSIRTPRRDVCSRTFMYRNVCITTGQGRWIIFFRNPAKNLGKIESTRCPRRRDTRGRNNSPSISPSSILKIHILSNLCVKSGTARPPSFTSCKAFPAGILHEARLTVMWGPPHWGAISYLLKPLFVKKNSVIRQKAANHRPRAFWRNMVQHLKVFFVAALSLRPSFWCPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEL6</accession>
    <name>F9WEL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 286</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002033">
        <property type="protein sequence ID" value="CCD15727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07390"/>
    <dbReference type="OrthoDB" id="1698685at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25425" checksum="1C6B7363D106880F" modified="2011-10-19" version="1">MQQNSSIIRKTCPQCCLPYHRTFFSPILAFSIRIPMSFYTITSTRTIPWSMEKDVVDVLLDGVTSADRINLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEVNVCDAVWQYLPYLLWKFRLSATPLVKHFGPTQTWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPVPQYQPYQGVVLVEAAPAFIQVPYSTMGYLVPIPMSPRSWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEP4</accession>
    <name>F9WEP4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein TCIL3000_5_5280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_07670</name>
        <name evidence="3" type="ORF">TCIL3000_5_5280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575318">
        <property type="protein sequence ID" value="CCC90763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002044">
        <property type="protein sequence ID" value="CCD15756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07670"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_5_5280"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCC90763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17932" checksum="D68A8308C2A3DB86" modified="2011-10-19" version="1">MREKHPDHDESLRPQPRAKPKRKAVRSEAQAQDEGSRSTELAGGGDGEGERPRKRPRMGRHKESEEGRNHVCHWSSSAYKQRYSLVWHTRTHHDHATTGKRKIRDGKVAVTPLLQQSLQCPHCPMKCALKMHLTIHLQAKHGQPKKRGRTQPSEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WER9</accession>
    <name>F9WER9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 308</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002057">
        <property type="protein sequence ID" value="CCD15785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07960"/>
    <dbReference type="OMA" id="CERAGCH"/>
    <dbReference type="OrthoDB" id="971884at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="285" mass="32009" checksum="C6716EF4F10A992D" modified="2011-10-19" version="1">MNVRIGVSFDLLGTLIVVRRSPGYQYCTYFRSYLERKGLQLPTVDEPKLNASFKRSIKSEMEKCRKLWVEKGLGEPKEAPLSGVEPGEVFAFWCSVVDGTLGNDSDYYFDDKEIKSVIQEARKNGEWKDFIEDVVERFSTPEPYEWLPKTVNTLRALQQWRQQQLSHGVLCAIPTVVSNSDSRLAHAISAMLQQEEAGERLVGGLFFADTVGVAKPSPRGIMLACESCGVTSVKYWVHVGDDEEDREAAERAGCHFIRCSSTEGPDWGGLQAKLQELCHHALRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF93</accession>
    <name>F9WF93_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 362</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002117">
        <property type="protein sequence ID" value="CCD15961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09470"/>
    <dbReference type="OrthoDB" id="1728734at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="158" mass="16841" checksum="AD19F72C78C95305" modified="2011-10-19" version="1">MRYAYAREDTVETMSNCGVTSELHAAHCEGACVRPVCAGHGGCVWTLDSTVEEVLLWKYGNVTEAHLHKFLLDHFGSTFGLPDMSLIAFMNDPSLFVTDTQVLSGITSSAAYVDLQAMLRAVNVLNSAGIITLEQWSALSDAPAVVERAAATATSGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFA9</accession>
    <name>F9WFA9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_01200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01200"/>
    <dbReference type="OrthoDB" id="1709792at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19030" checksum="0DEB5B8E4070A04B" modified="2011-10-19" version="1">MGLEASSDGFLPYRSSFEVGRLGAVPVYLGAPDGNMLGATKGGLWPWGQLRGNEMAHLNHVAFLFCWIVGGCLSFNTHAIYGGQGVRAGGGGVWRCCVSGRGLTSAVVVMVIHPNCLTVRMTRWRDVKALLTCTECDGGSWPGRANGIPLMEECCSGWPGIGSSCDRPTGRPVERARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFF5</accession>
    <name>F9WFF5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 382</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002139">
        <property type="protein sequence ID" value="CCD16023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09940"/>
    <dbReference type="OrthoDB" id="1783609at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19264" checksum="33A50A53EF0DCC76" modified="2011-10-19" version="1">MSKGMANDVLSKNVLSPIAFFFSLLIIPLPIQRLLLRMCSFVSFLLLSVQLVPERQNSLRLPPLLGFLLLLQLSSRKPNRCVPSDCWKDRNENNNNNNNKWLSATAAPHSGKGLLSLTNKDLLTVCFLNAVALSGAVLFRFKAPFFLVVVVVCLFPFLFSSLELLPTLLECW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFG5</accession>
    <name>F9WFG5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 384</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002142">
        <property type="protein sequence ID" value="CCD16035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10030"/>
    <dbReference type="OrthoDB" id="1727904at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16646" checksum="97A9FC574D2E5A3D" modified="2011-10-19" version="1">MKTTWTNVTVPCLNSDGGAEYLKALEKFKQNLDPLVEGDPTHQILGESNFTNRGGCGGTLDDGVCVTYSTKREEKTWWSELDEAVKKDEEKRAQENGRREDKKQAAQLISAPQNVTLDRKNTTLNIILRASSTYLTPLFLSPLGAVTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFK7</accession>
    <name>F9WFK7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10460"/>
    <dbReference type="OrthoDB" id="1719581at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="254" mass="27627" checksum="0C884F798BCEAB89" modified="2011-10-19" version="1">MSTSAASSGSVSNVDKALVDENHSPPDEQPPLIKEKKHTKYFDPSADQTPAKALRSNPPDAHPIVASPVGATQKRGECLGDEFGKPVSKAPDDYSSCDDEKKEVKEGNGKSEEEMNEVAEEETETEEETESEEEEEEEETESESESESGSGWDSEDEYQSDEYEEGVMGGVVGEVQKPKGGSGEMVKVLYHEKKPSFDAAASTLENKVSKGAEEGVETCDGVCACQRRGYRVALTRVLPAHPFPLDDFPFEPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFZ4</accession>
    <name>F9WFZ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002206">
        <property type="protein sequence ID" value="CCD16224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11720"/>
    <dbReference type="OrthoDB" id="1675234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389090" evidence="1">
        <location>
            <begin position="22"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="299" mass="34579" checksum="EE0B0DF56DC5861C" modified="2011-10-19" version="1">MAVMIMFLCRWICIITGRVCKNEPHTMRLLNAERVVPCLWPRGDIDITPELGQSYDIEEKLVMSEKAQVVAVFSSALGWPNRMHVPQQPLKALPAPQGGSSDYTHLYIRKDMMSGWYIVEEQLDRWLKPNDCRMPQYYITIDTAGIGKTRGLGPFLHFQLLHCSSEELCTLTYFSKDEVCILHWHKGDTPGMVVYYDVQDGISEMAHMATQCRKRYTISDEHKKDIFPYSFPPCWGALVMSTPSPDRFEHWINRYHTLPTSINCYSNLEFRAVRAFGRLSELCQEAPPGAETVEWFKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGA4</accession>
    <name>F9WGA4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_12770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12770"/>
    <dbReference type="OrthoDB" id="1696283at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="224" mass="23884" checksum="1C1E5DFF716F2093" modified="2011-10-19" version="1">MECVVSCMIYAAGVCGGVAIPLLFSLENSAMALISSKHWIGVSFRSGLTTGKCVNIGEDVCEHVITKHTSGPTTNPADSGHVGHGCFHARAGSDVILIFGRCFISGRCMGNGASYDISRRSLSASPLALPAFHSRFKGPLHMCVDNTAVMRIMNEGNTRSSGLVHETSATDRVLRAARINAAWSYVPSTVNPTDGVPRGCVSGDRTLLALRVRRVEDTFSPSDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGA5</accession>
    <name>F9WGA5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12780"/>
    <dbReference type="OrthoDB" id="1685087at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="27635" checksum="32B7F99B9BEDECAA" modified="2011-10-19" version="1">MGQLDPPWAVPEPRAGLTWTGYRGHGTLRLWQGRRVASREEGTALPPQEVNGGALSLEWVWRRMEDEALHLFDEVWNLMIAAGGIAKRGMELHLRIATGDAHVMEQAVVSLVMLLICQQKDGLHHFLWWRARCRSTAWSEVRNTKTDYGAEVPRGHTSQYLSAVCNESVALFDLMASFFNVDLSRDIRACFRCHTKSGELVELDRLPMGYEGNTEIVHTITRALAGDADVVRTEHAAPNHMRIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB4</accession>
    <name>F9WGB4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_01450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002252">
        <property type="protein sequence ID" value="CCD16348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01450"/>
    <dbReference type="OMA" id="DMVNRQQ"/>
    <dbReference type="OrthoDB" id="78349at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="2">
        <location>
            <begin position="8"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="94"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="214" mass="24507" checksum="63BF578D6EB31416" modified="2011-10-19" version="1" fragment="single">MSKAAVSRPRVYVRIRPLNEREKREGNGELICRGDPRIRDTLYVKRDDGGAELQTRFDHVFDRDATQTDVFDIIGPEVLNTLFSGYNASIFAYGQTGSGKTYTMEGDHSKGERLGITPRLVKAIFERFKENADITRSVCEVSMVQIYQEKIQDLLAGQRQLEIHMDRTGQYIARDATWTRVRNLEESMKLYKKASEMRATSATDMNLVSSRSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGD4</accession>
    <name>F9WGD4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002260">
        <property type="protein sequence ID" value="CCD16368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13060"/>
    <dbReference type="OrthoDB" id="1611900at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="228" mass="24702" checksum="D2A3998027BB2DAC" modified="2011-10-19" version="1">MFPHPRPLGAPVDLGNCAPVAPFDMSWPEHPWMEGEEGLMVGSVGHRRKSFCGPRTEEEWEELMARRECARTESGHGRGSVQMGVGGTALGSGVSTPNDSGCEVLRDYYGDMAGRDGSARRSSQNSMGGRRVLGGRTASMSRSNASRERSSYGSLSSRRQKVMEEGGKWGNNPEEYLPANPTDLMDAAHSLFGGMYEGMEGPQEVCVLRQTDTKLYDTGRAFDTGKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGL6</accession>
    <name>F9WGL6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 514</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_13740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002286">
        <property type="protein sequence ID" value="CCD16453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13740"/>
    <dbReference type="OMA" id="RILCEVH"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390354" evidence="3">
        <location>
            <begin position="23"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="513" mass="56530" checksum="D9712B5CB0C59770" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGQ3</accession>
    <name>F9WGQ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 529</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002303">
        <property type="protein sequence ID" value="CCD16490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14090"/>
    <dbReference type="OrthoDB" id="1661479at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="510" mass="55167" checksum="4B986F08C3F0BF93" modified="2011-10-19" version="1" fragment="single">MSLLLPHISFCLTSFVFILNYCFHVAYSALVESAGSAYTTPGHRVSSGLFFPLLICQYILRGRKVPFDYRMAIPNEMAIARVEVKRICIRPDICFSHCFRSSAVDGIEGHELYISFDSSPDVRVDPLGLRTASQQEAMEEPRRVPCAVNRDLRNVVFVATQRTDAEGKPQNKDFTVELACRVWYQQSTAWDATAALSDASSSVSLTSVLCNKEPTKEKEMIMERHWELLASGSAKAMRHGAVTIDLGVVDAQAKERSTPSVSLSLFVEPLLFADEIKGEEVGLSERAMPTEDKKESPSATVGPKQYTLPPPPLKPGVVKPSDGATTCQTADCAEATVVLPKEGSVADSGRNGATLPDPARDGMSSVTVPKMFKYVTARWMLFAHIPPPVDFPHDNRNGVGGEEARFATGDSNGVNITNGAAEAVGGYTGLWRLALYGACGHILARGSPFSDTLYKSSGWCDALVAVGDDVVVSAGVTLHLQVLKQPLTHKDMNNGGVGAMHAHEISSYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT7</accession>
    <name>F9WGT7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 548</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_14410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002324">
        <property type="protein sequence ID" value="CCD16525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14410"/>
    <dbReference type="OMA" id="EWPWSES"/>
    <dbReference type="OrthoDB" id="571623at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043966">
        <property type="entry name" value="CBP110"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19042">
        <property type="entry name" value="CBP110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="999" mass="109697" checksum="AE173830948D8CC4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH27</accession>
    <name>F9WH27_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WGS project CAEQ00000000 data, annotated contig 584</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_15260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002363">
        <property type="protein sequence ID" value="CCD16616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15260"/>
    <dbReference type="OMA" id="VCPVSSM"/>
    <dbReference type="OrthoDB" id="132523at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="74"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="608"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="735"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD16616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="899" mass="100900" checksum="8AC3803E88A93D67" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHB8</accession>
    <name>F9WHB8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_16160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002411">
        <property type="protein sequence ID" value="CCD16710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_16160"/>
    <dbReference type="OrthoDB" id="1672912at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395054" evidence="5">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="356" mass="39411" checksum="11AC3F8670FB070D" modified="2011-10-19" version="1">MLIQKMMKFCMFVFLVVVGAVIASGTDHNQEAHKALCDLLNAAVRRWGSNGESLTEPLKSALNHTVFGSNGVGDLEGLRKALPKVYDEVLNQSGSRSFSCGQRLAGQASSGGVKHERWSGHSASHDLLCLCTLGDNGWPLNNTGSEKLCGKSLNELGTQKDQGWHGKGSGKPQMEAAWTNVIKECLQGDKKGTNLKNAFDDFKKTLKHTTGDEEQHGNRHILGKGDFSDYPCSGNGQICVMYYNEAKPTGEQHPKPWWVELEYAIKKDEAEKEQKKREEEKRKQDEINQQKLKQQKQSQHQDVPRAAALKAANTEMQEKEPDDTQNISNPIATIEEASGTLIIPPCPWFLSAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHU6</accession>
    <name>F9WHU6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 695</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002487">
        <property type="protein sequence ID" value="CCD16891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17740"/>
    <dbReference type="OMA" id="THIPRRH"/>
    <dbReference type="OrthoDB" id="1160448at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="431" mass="46857" checksum="1374D19002DCB23E" modified="2011-10-19" version="1">MMSLLFVLLRIMCFVLLFAVLLRVKKTRVRYLPSRRTRVSRHHGETCAWLERLVSAVLDMFYCAAREGNESTEQASLPSDDFASRSASKEMGGRGASDTRVRSDSWRLLEMFEGRVVAFLEDRGIAAQALFQIHSIGDKPPIIRTIRVINRTGLESAPLTSATLAAAGPSAGVGVPVTGDKNMGTAAAPTNASLPGVSAPPVAASGGGGVARPFLSSRAKLRSLQQVFHSGSEGVEKWRNDLYAEEGAAASAKGSASAPPSVPAAAIELEAEVEYAGGIDVRLAADICLARGRRLPVFVRVSDVEYIRAHVRLHATLKHEDATMDSQRKPYLQCTLWLESEPAFSFQMSTSLSRYKIHDFFALPMIAKFLFLRFVGYRMVYPHGAGVSFNIPLPEHVVDGGAYKWFSSMDDMETVATTSMMEGFRGCGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI14</accession>
    <name>F9WI14_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 719</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002513">
        <property type="protein sequence ID" value="CCD16959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18390"/>
    <dbReference type="OMA" id="CAARRIS"/>
    <dbReference type="OrthoDB" id="1243394at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="523" mass="57993" checksum="86EEE2DA20F4F2B4" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI72</accession>
    <name>F9WI72_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 738</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_18790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002535">
        <property type="protein sequence ID" value="CCD17017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18790"/>
    <dbReference type="OMA" id="CWGVISL"/>
    <dbReference type="OrthoDB" id="12773at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="34383" checksum="0A946857E8F752BD" modified="2011-10-19" version="1">MKVFSDAAACWGVISLKSSTVAAADAQGMREGVKTPLPQAPHTLLRVNVKLLQAQLVMRDGHDTPIHTTADRGELWVVYQSKKITAQCTASNVYSKGTYSGKLSHEIRPFSLDITVRDARVAAGTIHAFSIHAHVTTFEVQLSDTFVYQMQRLMRCLEGDSLPLEVDAAEIIGEVITPALSSEWRLLDTSLRVDFLLISEVLVIFSYDRSVQPPEDVVFQGSHIGNIFPSIHEAAITLPRVQCKDFRGTSVAEVWNVMCEGVTMELLKQMPQVVSGFVLLPTFSPIKNVIDRIGSFIFRGSGSSPNSQGPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WID4</accession>
    <name>F9WID4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002570">
        <property type="protein sequence ID" value="CCD17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19340"/>
    <dbReference type="OrthoDB" id="1703726at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21658" checksum="18D5376488923963" modified="2011-10-19" version="1">MPLNHLCASCPRASVTSRYTSQVDAPVTLPYHWSELTRCSFRYLLHQMEHYRTLRHALGAFLLEPFSLVLLCSPQLKILVHLVPLAHGLLRSRFTCLRPPTGCFEPFSMRHPRLHGFTSTAPAPTNQNHRHCVVSASLGSGSRVIWVVCRLWPRSYVLLVPSPWFSPFVLSGDCSSATDGSFAPRLLLPLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIE0</accession>
    <name>F9WIE0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 773</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_19400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002573">
        <property type="protein sequence ID" value="CCD17087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19400"/>
    <dbReference type="OrthoDB" id="1716376at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17385" checksum="7BDC4D3E3DA22153" modified="2011-10-19" version="1">MTWLPISLKNAAKCDKWYQLQNHHIAQSLNANGAWEKLFRVIPVHATFSVSTNKKTTAALFFSLSLMMSRVCGVCAVCSRDVFENGVRRVRVPSSPINISCRQEGESPVCVLWCCYVRVKGCMCGMCVEVWSLWHEGCVWVSFVGRRALAFCFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIF6</accession>
    <name>F9WIF6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002584">
        <property type="protein sequence ID" value="CCD17103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="15056" checksum="571D5BDFA2041A54" modified="2011-10-19" version="1">MQKNSSNSEITPKNPLFGPKNQKTKKIFFLHFFAKIWKKGVFPAGKAKKRLKQRNNPQKPPFRPKKQKNEKNFFFCIFLQKFGKKGYSPPGRQKNGSNSEIPPKNPLFGPKNKKTKKIFFLHFFAKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIP3</accession>
    <name>F9WIP3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein TCIL3000_4_3610</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_20280</name>
        <name evidence="2" type="ORF">TCIL3000_4_3610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575317">
        <property type="protein sequence ID" value="CCC90259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002621">
        <property type="protein sequence ID" value="CCD17191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20280"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_4_3610"/>
    <dbReference type="OMA" id="AQVCVEL"/>
    <dbReference type="OrthoDB" id="1430387at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="SSF49562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC90259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="182" mass="19789" checksum="B015E7DB9F148437" modified="2011-10-19" version="1">MGKLQICICGARNLENEKDLCLPDPYCCVRLGGKTFKTKVVNNSCDPVWNQTFRFHVSSGADAQVCVELWNRGIVTDNILGSVCLPLKNLTMGVVTDSWYMLSHSETSAEVRIRLLACDFGAKPQASEKWKVTRDINACPVFAAGGMPPPLPDPVTVSTNSNNMPMLKNMGPPVVPAIFASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIQ1</accession>
    <name>F9WIQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 819</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_20360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002624">
        <property type="protein sequence ID" value="CCD17199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20360"/>
    <dbReference type="OMA" id="CIVFEYY"/>
    <dbReference type="OrthoDB" id="915778at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="125"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="460" mass="52466" checksum="51543856CEFFB0A0" modified="2011-10-19" version="1">MNGQAAVVIQGDGLTRTAPIVTATKVVHGRNNLQPKATADSREVVHPRRSASKRDRDNADDNTQTAHAAAVERRETVDAKVPTKAQVQGTTKKKKITYALPNQSREEGHFYVVLGEDIDASTGRFKILSLLGEGTFGKVVEAWDRKRKEYCAVKIVRNVPKYTRDARVEIQFMERVRLSDVSDRFPLMKIQRYFQNETGHMCIVMPKYGPCLLDWIMKHGPFNHRSLAQIIFQTAAALNYFHTEMRLVHTDLKPENILMESNQAAVDPLTGRTMPPDPCRIRICDLGGCCDERHSRTTIVSTRHYRSPEVVLGLGWMYPTDMWSMGCIIYELFTGRLLYDTHDNLEHLHLMEKTLGRLPSDWADRCGTEEARQLYGPAGMLRPCTDPKHIARIARTRPVRDVIGEPLLADLICNLLHYDRQKRLTARQMMQHQYVRKYYPECVQHPNYIEGHAGASSGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU8</accession>
    <name>F9WIU8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 837</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_20800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20800"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19040" checksum="32E035D5D61E1409" modified="2011-10-19" version="1">MQVTSAVRQGENAEKATAVFIEYERAFDSVDHRCVIEALKAFGVEVHLVARIARFLQGRTAQVRVSSIKSEDIEMMCGVPQGSVLGPLLLLITAVDSPSNRLNEIQGFMHGFFGDDLTIICIHAEICRRFRKRRRRAWIGSPVGQRSSLWRPQRRGRSTRCLDPATKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY3</accession>
    <name>F9WIY3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002656">
        <property type="protein sequence ID" value="CCD17282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17014" checksum="86BE3B59EA275779" modified="2011-10-19" version="1">MALKTGTFVVHEAVLRRIWDLILRLTRSRVAISLQFVFSYCEAPRNKTASGAAGDENARPQNYPPWITDIVVVIQRQCRSETLEEIEESHRPRVYPSVHSPTMLDHLGKKPSLHRLREALLAHFHTSTSMFIEWSYGMLICGNGRIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ53</accession>
    <name>F9WJ53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002684">
        <property type="protein sequence ID" value="CCD17356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21820"/>
    <dbReference type="OrthoDB" id="1707207at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="21157" checksum="50E95EAF3AC23FC6" modified="2011-10-19" version="1">MSWYTVTSTRTIPWSMERDVVEVLLEGVTSPDHVNLYWFLRPVLAGLTVDLVCFTLRDFVRNPRHCIPEANVCDAIWQYLPYLLWKFRLSATPLVKHFGPTETWTKWHWDSWKIYYDNDDMPLEAIHEEIWRRCRRPPPPYQPFQGVVVVEAAPAFIQVPYSTVGYLVPIPLSPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK24</accession>
    <name>F9WK24_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 977</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_24710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002800">
        <property type="protein sequence ID" value="CCD17685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24710"/>
    <dbReference type="OMA" id="KSANSAW"/>
    <dbReference type="OrthoDB" id="922453at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="888" mass="98603" checksum="0F2CCC70AF0AAFF0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK25</accession>
    <name>F9WK25_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 977</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002800">
        <property type="protein sequence ID" value="CCD17686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15190" checksum="D2DBE7AA787D6559" modified="2011-10-19" version="1" fragment="single">MSTKGALTVATGWSTGGICRKHLGSEPFRTSPSHYARSLIPHPLFMMPSLALKGFTFTSRLSRHSPLLGRPKPCAIGSSCGVRMPTLYGGRRGFSTIAGGSCDSRSDVNACGASESQEGGSVVPCGATSFAIPHEQKLLVDKPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W362</accession>
    <name>F9W362_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1005</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000357">
        <property type="protein sequence ID" value="CCD11570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25430"/>
    <dbReference type="OMA" id="TYVRQWR"/>
    <dbReference type="OrthoDB" id="1288312at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="612" mass="66195" checksum="95DEF3E71A0F154D" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G7</accession>
    <name>F9W3G7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_00180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000408">
        <property type="protein sequence ID" value="CCD11684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00180"/>
    <dbReference type="OMA" id="IRCTRPV"/>
    <dbReference type="OrthoDB" id="289549at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="4">
        <location>
            <begin position="139"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD11684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="618" mass="69564" checksum="76E8348B819F3D8F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L0</accession>
    <name>F9W3L0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_26830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000430">
        <property type="protein sequence ID" value="CCD11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26830"/>
    <dbReference type="OrthoDB" id="1662324at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389845" evidence="5">
        <location>
            <begin position="24"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="97"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="439" mass="47548" checksum="D0E2E85A3CED4B17" modified="2011-10-19" version="1">MSCPLNVLALSIAVCSLMKGVGGNTGAEVQQVDNAEQFALLCRIYNVAKNPPINHVDLQDPNKIVEEINALNASFAEEKTPNETDESYNSSYTTLKPSTAREAAVAVAILSLITKKAHTILEDIRKVSATTDIENAKLEFAQVIFGEGGNESHLCEGALKDVGDRATACGLTGLTSKGASAGKNLVVDFFCLCAMRTDGKGTENVCSVKVGGKGKSDYHGWGDNKGPSGSSSMWASVKKACVNLLHTHPKSIKEGHEVIEDFLTHLKDGGLYRWGTTNNNGVEGSSRKAGMLGTSVGPKEGDHGSGLVCDGKRGEKDVISPRRSGGGNTVKSGGVCVYYGPEKWEDNIDWLRKYKTALETTDAINSKTTTIQRKIEKLQMLLHYAEKIYETTKVITEIQKPQAVAAFHNATAKRLTAYNAARRYHHLNNFIIPWVLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3S9</accession>
    <name>F9W3S9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1100</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_27460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000463">
        <property type="protein sequence ID" value="CCD11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27460"/>
    <dbReference type="OMA" id="KVECMES"/>
    <dbReference type="OrthoDB" id="1419156at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23300" checksum="4021D16E6240114F" modified="2011-10-19" version="1">MREKHPDHDESLRPQPRAKPKRKAVRSEAQAQDEGSRSTELAGGGDGEGERPRKRPRMGRHKESEEGRNHVCHWSSSAYKQRYSLVWHTRTHHDHATTGKRKIRDGKVAVTPLLQQSLQCPYCPMKCALKMHLTIHLQAKHGQPKKRGRNNLLKAKCEESAAHLLKFPSLRELRKTHGLETLLEGEIFFSAQLVSFLKELFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3U8</accession>
    <name>F9W3U8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000477">
        <property type="protein sequence ID" value="CCD11824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27670"/>
    <dbReference type="OrthoDB" id="1702490at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="251" mass="28914" checksum="F94D35BEDFCA7EB0" modified="2011-10-19" version="1">MPKKKPRRFLSWQSLAHTHPRRCFSSQIFSQAESRMVRVTQRSSRQKFPCTHSHWSSVWTQTWCRYWQSCITMFSRAFALDGVARRMYSRVFSWGSYRAGSLRNAAGLAVGRVVEPNWKLHSSAKKSASGTSSQNQHPTSSTSLIREDDFNASGCLGGTLQSKRRALRLCGFWCWRCCFRCCWCPGPPRHFRRRHPSRGGRWRGGTNGVVGTSTAVSRAFRRRNRGSFSIWVCSCRFAESRNVVILRQAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W412</accession>
    <name>F9W412_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_28330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000502">
        <property type="protein sequence ID" value="CCD11895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28330"/>
    <dbReference type="OrthoDB" id="1718677at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21425" checksum="3284289E8760273D" modified="2011-10-19" version="1">MSPVRQSYFRPIHTSPSISLCPTLTAASQVVAADGGLCDVPRQMVHGSHISLARLKLTHIIEHSARLPKAFPFTTSGTFSGSHTHTHIRSHQDATCAPMDAATRSHAFASRRHHRLPTHHMPQPPERLIGAHQTHERHDVEPYAQFGATLLISNGAHRAQIPHFHFPLPDKANSPRTNTARHDHEEKQWKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W422</accession>
    <name>F9W422_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 113</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000505">
        <property type="protein sequence ID" value="CCD11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03010"/>
    <dbReference type="OMA" id="IYCGHGG"/>
    <dbReference type="OrthoDB" id="1220616at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="699" mass="76224" checksum="7BFB34970A121FCF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W433</accession>
    <name>F9W433_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28520</name>
        <name evidence="2" type="ORF">TCIL3000_0_56900</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000509">
        <property type="protein sequence ID" value="CCD11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001785">
        <property type="protein sequence ID" value="CCD15130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14024" checksum="49192E95CC32A128" modified="2011-10-19" version="1">MSSAPSRDASMPLENPWLRAVSTSIRAGGGSIIVDINPPISFPSSYLSMPFITLPTLVCSETCPSLSLSSSDTPASSPSSALFPLKLFRRYLPKSGAGHIAIADFNTLVNEEIDILNHRDAMVKNSEEEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W436</accession>
    <name>F9W436_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000509">
        <property type="protein sequence ID" value="CCD11919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28550"/>
    <dbReference type="OrthoDB" id="1719919at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17644" checksum="A172FFF643C12A7E" modified="2011-10-19" version="1">MLLQVILFAGQILARTLSIYSQKLLISRHPHVFHISMPYSRMHGWPLKILASAAHLRPLRQCPLPDLNPLEASNFGRSLYQGIEPLGGRHGVQGRHRTAGGRNPKNGIHLENKKIVCISPFPKLRNEETQCHCQDPLKSFLIGKMNITENEESLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W492</accession>
    <name>F9W492_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000532">
        <property type="protein sequence ID" value="CCD11980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15794" checksum="CFAE8DA84DFDA075" modified="2011-10-19" version="1">MFQRCQGNLTHTFPLIGEEVMWPKRPMHRGKLPFRGLPVLSTQHCPNFPHFLFFVAFDASQSCRVRGRTPSPQLPSICSRQTPNPTRSPRRNPPRELSREGRLNPVEVLYFFSAHNAPISLLSFSYFWCHSLLLNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4E5</accession>
    <name>F9W4E5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1174</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_29560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000546">
        <property type="protein sequence ID" value="CCD12036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29560"/>
    <dbReference type="OrthoDB" id="427950at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="288" mass="31731" checksum="51D80818F3CFEAE9" modified="2011-10-19" version="1">MHCDTELTHTVSKGVFNISEAAKGSYCSSHDERGYHTANLLKRDALPTDNSADSGFLDRPCSHPSAVTSYNRENRSPQKGDLAVKNRLRTGAATAPLLRRYRLCEPLQKEGTPKNHGSGALGTGQGTWASPHDALPNVSTIFSPIQIPRLIEGRNLEKSCNSAHRPTRTRKGMNPRLAKQTVVPSGHVLNTHEPRGCDLNVEGNCGSGIAPSCPTCSDANCIHGREGILDYVKMQYELRACRGALHEKDVELERLQQRLASAEAEMLSTVSRFERKIMEMEEHHKQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4R8</accession>
    <name>F9W4R8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Meiosis-specific nuclear structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_03160</name>
        <name evidence="9" type="ORF">TCIL3000_6_3960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575319">
        <property type="protein sequence ID" value="CCC91141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01000594">
        <property type="protein sequence ID" value="CCD12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03160"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_6_3960"/>
    <dbReference type="OMA" id="EHKRFLR"/>
    <dbReference type="OrthoDB" id="976940at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026504">
        <property type="entry name" value="MNS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043597">
        <property type="entry name" value="TPH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19265">
        <property type="entry name" value="PTHR19265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13868">
        <property type="entry name" value="TPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPH" evidence="8">
        <location>
            <begin position="72"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="77"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="255"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCC91141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="436" mass="52603" checksum="0EDDB570577DC958" modified="2011-10-19" version="1">MDAGNARVERLRRVNRYKAVQAELAREREEAEFTAMREKKAQAAARDEALAKELAEQQRLELKDAKMLQFVRDLPELRNLEAQLKHARMKVDRSDQVDECRKRRQNQLEEEREFCAFLAAKEAREKAEDEEKRRKAIQAFKEHQDAQLKLIEERRAQAERDAEKNRLERCAVDAVVSRLREKEFVEALERREKQRQFQAEQDEFYRLRKEIKESERLRQQREDEAIEAYLAEKGRRKEATEKLSREKEAIKARIYEEQSKKIMEERSKREELEGLLNDYYEAERMAKERQAIQDSKERSEKLADAVRQENWVLIQERIKERDREREEEAAMRQRIVEEFALKAKEKRLAAEREAELRKQKMLETEQRIERFRELKREEARLAAQVEEQERKRAEELQEYIRRARAQLLDQYLPSLGQHAPVRWLTSEEKDKYGFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4T6</accession>
    <name>F9W4T6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1227</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_30900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000604">
        <property type="protein sequence ID" value="CCD12181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30900"/>
    <dbReference type="OMA" id="LHGHMLM"/>
    <dbReference type="OrthoDB" id="1068645at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="5">
        <location>
            <begin position="323"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="556"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="578" mass="65271" checksum="7CA7CB0383853BFB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5E1</accession>
    <name>F9W5E1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 1317</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_32750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000704">
        <property type="protein sequence ID" value="CCD12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32750"/>
    <dbReference type="OrthoDB" id="1671364at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389813" evidence="8">
        <location>
            <begin position="25"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="394" mass="43155" checksum="783E6514D2150DF7" modified="2011-10-19" version="1">MIMKTSSVGWVMACGLMFCSEVSCVSSYYPKAIPTEAGVSVCTLSRKLKDVPSWTAEKLTELKKTRDEYASKFLDWKLHFHGNSDCGVNESILENIRTDLEKVNEEINKLSAKAIRAGALAAKSAGRLDEFIVVFANARKTGSVFDETDSKTSNYCLGGGGNPARRRNLFDCFPKGEKIEMGENNLARIPESTPHKEEPNLTGAIKNVNHSAMVGYVKRYDGDDHANCNLINGGSGFLGGALHDRLWWGGGILTIGKSFEGELKKDSFVAGGIQDSKDNKALWTASPHTIPHLKKTLAAFEAFKDAAALIAQKITEIEKIEKKIEPCLSNETMEDRPTQSCFKNAVKLNAELQAANALLARYHKEKGPLPSGSPSPHAQGVMHFLYLIAFLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5H8</accession>
    <name>F9W5H8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_33100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000715">
        <property type="protein sequence ID" value="CCD12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33100"/>
    <dbReference type="OrthoDB" id="1660870at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="149"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="480" mass="53534" checksum="F0C4FB309FECAF95" modified="2011-10-19" version="1" fragment="single">ARDTALSARLHFTVEKIIFFYPKFCLLKKGIKVPKGYRVDMMRIMFWMVVCSVVMGSFVKEGRVKATTEVSVSESDNTEPFSLICRIYNVAKNPPTNHIDLEEPLRIVQEVDALNTSLVEPKLHNETEQMVNSLEAVKPTVTWEAALSQLSLNQITQKAHKSLEEIEKIKSSESLEKAKADFSQVIFGEDGNESDLCHATVKDVGNRATACGSLGQETKGKSAGKNLVVDFFCLCAMRTTSSEGAKQACGFYVGRIDKHYGWSEKGPWGSSTMWASIKGGCGKHMQQHPKSTAEARHILDQFLKHLKTEGVYRQIECEPWCNKGNNAKVKGSHRKAGMLGTGITVSAGSDFKCDGKEVGREGKKSKNVNPGGVCVYYGPDKWEENIEWVRHFQTALNTLESVNNKTATIQRAIEKLQMLLNRAEEIYETTQVITEIQKPEGLAAFQNASGDLTVHNATRTRSYSHRPNPYFIPAWALFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5L7</accession>
    <name>F9W5L7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1340</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000730">
        <property type="protein sequence ID" value="CCD12469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33460"/>
    <dbReference type="OrthoDB" id="86440at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="602" mass="67775" checksum="9A2383E83C6F8BEF" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R8</accession>
    <name>F9W5R8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1363</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000755">
        <property type="protein sequence ID" value="CCD12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33930"/>
    <dbReference type="OrthoDB" id="1739563at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16030" checksum="661087B6370FD337" modified="2011-10-19" version="1" fragment="single">MRSPLWLLWGCAGPRCVREAHWQRSGCVAMWTVLRRMCSTKPLLALERVEVAHSNAYARRGVTVGFTSCATTHAGGSRGSSLSSSSADANSGEALANYVNFVADDTSGPPATKKNVAHPMRVYPLHPAVENLLFYRSSQKLRSPLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5V9</accession>
    <name>F9W5V9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1388</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_34300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000783">
        <property type="protein sequence ID" value="CCD12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34300"/>
    <dbReference type="OrthoDB" id="1662309at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="653"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="230"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="677" mass="79606" checksum="45ABC75D2EE27C9F" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W611</accession>
    <name>F9W611_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1410</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000808">
        <property type="protein sequence ID" value="CCD12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34760"/>
    <dbReference type="OMA" id="MSPVELY"/>
    <dbReference type="OrthoDB" id="652922at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="46421" checksum="D658A0889BF2AE20" modified="2011-10-19" version="1">MMGDVSEYVMQFCLDETGNSTGCGNRRRKTLIPLSHLAFIPPIYLLIVNSFLCTAINAMFNYFSFGRSAIETTVKGWTRAKMLIKHSVILKEPDDTQNLLKERENSCETDHLCDSGSLGIDYNDSAAFFRGMLNPDSLAFESPRVPASVAEEVLCSSLDAVRSSVQQVVLPFHPTYMIVSITKSLIMLLVIQYHFNFRGGWKRLVVCSAANLMSGLLSPLLEYGAGLLLPVDSNTEMKPAPDWEEQGDTVLIARILALVGQLQLESIETVFIQGCTFILFGAVFLPPVLVFCVLGVVLLFWLYWPLWLIFGYLRRLYYQPTSSNLQHWLCFHKLSLTPLREFVSIFCLKVLALFLLQWTTQSSFLLGFEILQGVGYGEAIVELIIYQVGTLVNPLKMDWFHRLCFLGQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>F9W631</accession>
    <name>F9W631_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_03550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000817">
        <property type="protein sequence ID" value="CCD12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_03550"/>
    <dbReference type="OMA" id="KQGDLYD"/>
    <dbReference type="OrthoDB" id="157058at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="PTHR24115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="10"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="354" mass="39051" checksum="F0DF2D0E990B5CF4" modified="2011-10-19" version="1" fragment="single">MGKKSNAAENIKVLVRCRPLNEKEKAQGYKPSVELDLTENTVTVQSPVGEPDRWTFDAVINNTFTQKDIFQQFILPLVDSVLDGFNATVFAYGQSGSGKTHTMTGKLNDEELKGLTPRSFQHVFDRIAAMKGTEPNKQFSLYVSFIELYNGKVHDLLARQQVPLALKENKDKSFFVQGAHIPQVKCIDDIFQQMEEGTERRRVAATELNADSSRSHSVFTLIVECTEISEDGDSRSVTSKLNLVDLAGSERQSKTGALGDTLKEGCNINLSLSALGTVIDTIVKGKGHVPFRSSPLTMILKDSLGGSSKTVMFANINPSEHNVSETISTLRFADRAKQIKNKPVGTGHQRSEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W656</accession>
    <name>F9W656_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1425</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000824">
        <property type="protein sequence ID" value="CCD12660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35200"/>
    <dbReference type="OrthoDB" id="1723726at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19089" checksum="579CD05AFF99F9E0" modified="2011-10-19" version="1" fragment="single">MSDFNYDRMFLCRPDDLDDISYIKEDIKRQMNIFDDEDDGAVVSTGKVEDLTDNYGVSPEEINWIPEQRVAMQTDGILSESIPKVQTPKESGRSSAEARRVAEACDTKSLLTSASLFSQPLTSREPQLLESQCRQVPAAAAPLAFTHLTRAPWDPPPRLCANPFRIRAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W659</accession>
    <name>F9W659_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000825">
        <property type="protein sequence ID" value="CCD12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="111" mass="12832" checksum="C100C74A00167D2B" modified="2011-10-19" version="1">MNMAAVMRLMKKRRTTHTLSFTQPPPALQGLGRKIRERAGKESKPDVRIRAAMRQYKTNVNQTLTFNTIISLLSKKSKERKREGVVPFPLLVTLFTLPFDLRSPFPTFQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6A8</accession>
    <name>F9W6A8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1442</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000843">
        <property type="protein sequence ID" value="CCD12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35700"/>
    <dbReference type="OrthoDB" id="1662240at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="466" mass="49148" checksum="3AA1EE0AF8F9B224" modified="2011-10-19" version="1">MRTKTTLTSGAPYKCNVLHSDGYSFLYSARGRRRRQQKCPWCGGFGCPANLHFGCPSPADKFHFSPEVDAVQLTGNDSGVRKRHDGDPLHVSDEGCLVRDGACSQSTRNRVPLFYCLLCGKTLLSAVEFSRHTCCRGGDEISSLNNGVPSVSGGDVVSSPPDGDTSPMGVCRDVKLPSAEVSGVALSDNGPKQRRLLTDSGLPSGGLQKYANNTTAAQDPPIASGEKATRLLKETVGINDGEQHTLLRHSSPKGSKGAPPRVQHSSDGINNHVGSSQHGAPSGGTAVIAIPTASSCTTERKPVSCSEQEHPFLDDVDVSLSSQHSVVVARRFSDRGTGQSSFCPGGPDTSSCCSGSPRARRVQIEDPNGESPRGRSAGFRYAPRMTSHVTFALGVDGQRRSSDARSDTSAGPGRGGGVSPLPFLSHTRGKKASVSRSAPPVKNLQGSLLSSKPRKKYRRMSGPGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W758</accession>
    <name>F9W758_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1573</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000989">
        <property type="protein sequence ID" value="CCD13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38390"/>
    <dbReference type="OMA" id="PRNITKP"/>
    <dbReference type="OrthoDB" id="29964at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027912">
        <property type="entry name" value="CFAP54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14858">
        <property type="entry name" value="CFAP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="883" mass="97157" checksum="CE0344E2AE9B97C0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W771</accession>
    <name>F9W771_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1577</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000993">
        <property type="protein sequence ID" value="CCD13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38520"/>
    <dbReference type="OrthoDB" id="224373at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="485" mass="57684" checksum="A8513C198869898C" modified="2011-10-19" version="1">MKKMCQDFILAKHRISRKHSFKVLRELYLLRRFVKGNLARKCLHKWRCAYTLAVFLRRKTLPPTSDYTLLEDCFSWWRRSYRDRIADRAYARQCVVLVLQQMRRRIVWKAQEKAAARHEELNLKRQSFAAWSSAWQLRKLCSRFELRAGRRLLQRIMTVWRIRWLRRESAKERLRTFYAVQSRGRVIRSFYHWRQRLYLKRGRRRVSKTLERSLAMAVWVRWKGRLASRQQLAGKDESRASNTRCTMLARAVWRIWRQRYAQRQELRHAAHQEELIERIKTARKQRMMAMVYFTWKRKVHMLRRRITSKRSGNVATGNALAGLNQSFQNSDTSQSASHPVNAVTNVETGQWDMCQQQRHNVFSTVHGASITRLKRWYDPNEPLGELRTERLLLHCVDSPRWKRMIHSRLFTSNKRKKPSRNAKEVEVDDPYLSAYPLPRHLKGVGGPAWLSLGDGSVDVTESLPSEIEIDPYLSLDGSELGIQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7D9</accession>
    <name>F9W7D9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001012">
        <property type="protein sequence ID" value="CCD13105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38900"/>
    <dbReference type="OMA" id="CKAHEVE"/>
    <dbReference type="OrthoDB" id="164010at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394738" evidence="1">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="388" mass="43887" checksum="5F941F8D81810871" modified="2011-10-19" version="1" fragment="single">MYICIYMVGLSFFCLALEHFSCVNNYNAAWQTGTHSSIKTVEEGGNYRLEVRTTNEISMLSNTRGYSRHSAALKSMKDAATLQCALCPALRMKGRCKAHEVEQRFRTKIAAAKEKELHRSATELYLLQKEMLDDQQGTADAPKITPQIAIGNIVEELKKDNSYLQWNLEAEVMEMMTLSGIRPCRYSHQSQLLVALRPVRTSMKSIWSSELGAKGKLEVIHRTPSEQRLMAERKRVFASMTPLQRCVVCLLWQRGFVVPQKIICDVRRQMESVEDDSYGSDGECTAESKFQSEENRRVSVMSCQLSIGAVDLSSLPLVTAYIARNPDDLVIHKETLLHFTDGDAGEGKNQSHRPRRTAFFPSNWTEKHVNLSTPQHAHEVVGAIVWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7F2</accession>
    <name>F9W7F2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_00330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001017">
        <property type="protein sequence ID" value="CCD13118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00330"/>
    <dbReference type="OrthoDB" id="358185at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="535" mass="58908" checksum="FC8755B96F347DC1" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9W877</accession>
    <name>F9W877_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_41560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001146">
        <property type="protein sequence ID" value="CCD13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41560"/>
    <dbReference type="OMA" id="AMANDFK"/>
    <dbReference type="OrthoDB" id="1668615at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389985" evidence="4">
        <location>
            <begin position="25"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="88"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="45525" checksum="F22B1A4507B0B73F" modified="2011-10-19" version="1">MMENGMKYVAVFILFLLRCPSGMADKENAGEAELFCQIRLLAENDPHKLVFRNEEREKQILRRIERIGPEIRRFVGEAHRRDASLIARFNVIVKGVKKLMGNVRDLRRKAAEKRLSAKRHLHQVIFGDYGGEGKGELDTTPETVKKIFNGNTFKDSCGGNGDKMAGKSLINDFICLCAKWIQLDAVFNSHQDHSICKYGVTTAMANDFKNWTDVWYFNKHRICINTAPFTPTPKIINSIVAHFTRALEREQHNFQVEGVFGYVKTESNSQGECNTTNVGSTCVNYKYALKNGGIQWVNRLKNASKDLEDMERLNKKSESSLPQLELLEHNAILLYEEAKYSTQLPHANETAFKSTNESYEDILTNDTNTLEKLEEEDDSDSTWKGGPSLCGFFFFLFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8N7</accession>
    <name>F9W8N7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TCIL3000_0_43130</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">IL3000</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001191">
        <property type="protein sequence ID" value="CCD13571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43130"/>
    <dbReference type="OrthoDB" id="1672513at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="10">
        <location>
            <begin position="47"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CCD13571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="403" mass="43747" checksum="9EBFD265A3827B4F" modified="2011-10-19" version="1">MRKVTNKVEQGLTVMVMELSSKWWWLVASSVFMAWSSAFGEGDTPKAIPTKAGAAICTLSKTLKDVTPWATQQVEEGAAKVTHLEMKLLEWQTKWVQSKAQDKGSETCKMTGFLFRQVRKEIDKVREEVERLEREASKAAAFAANSAGRLDEFITVFANAQGSSKYCLGSDKAATTGELRDCFSGTDFSEESLIDIGERASAQEPNLFSRIESIKYSKMISHFTAGSGGGCNLVKGASGGILGKANLEKYLWWGGGILTIGAGFGGELSSTNLIAGEISNATNSKAFWTADPAQQIVHLKNASDAFKAFKAVQEAIQDKVKSIEDKIQSCMGGQEPGENNTEQNATEQTQTSPTCFDNVAKIAADLKEKRALLARYQKVKGWIPPSSASHPTTQFLGLLLTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8P4</accession>
    <name>F9W8P4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1757</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001194">
        <property type="protein sequence ID" value="CCD13579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43210"/>
    <dbReference type="OMA" id="DYNMSIE"/>
    <dbReference type="OrthoDB" id="1257705at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="267" mass="31186" checksum="6FABB32F3311A771" modified="2011-10-19" version="1">MSGDSRAIHNANAVGRAYSQLLSSTLNLEKKIEKYYLKEEAVIRERVMLLDRIQSNIAEERRCLEIDHQECRSRISAARSSQHVLRGDESKVSQIASNTEAQLDKEEASLDERLSIVNKRMEEETRELERITEQISKYESTMNHLLKREEGQKEAERELEKAQGELKSVEKEINERKASLEKKQESISVRNKSLEARQKELALYQEEFREHLRRIEEDERRFGIYNTSCKVAPSVSLREIMDDYNMSIEKESQCEEIDVDDDDDVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8S1</accession>
    <name>F9W8S1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1770</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_43460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001208">
        <property type="protein sequence ID" value="CCD13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43460"/>
    <dbReference type="OMA" id="GRMCEEV"/>
    <dbReference type="OrthoDB" id="1490276at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="40603" checksum="58989F5CE8541F23" modified="2011-10-19" version="1">MRQRLRYTREELLAARDTLNMDAFPDPVSPDCPMLTDCDVQLHDTIVTRRQKNDRALRLPRTEGVRSDDNYEGGSRCSAGIEFSAERWEGFGEYVAPRSGSGRMCEEVVNRHQKRLIVPLRLHVPVVTIDRPKKGPPWEHDGRIIEPHLNVDTERGMIARLRELQVLRDLHQHSPSTLLKGKLLLKSAPEVKPCVSTAPCGVGCNNKVTPPPRSSKVNVAAPLSAGSKGAPDNFSLLPLAETAVPPVNISLFKSDVGSRYFQFTRTLGLWEYLTVHSGLSSAAGTTAVDRKEITVKDNNGSSDIRSSVGPDDAATSHMDRGIQANTQGVPFPVRRKPHRRRTNRTHAEKRARRSEIPQEPAQRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8X5</accession>
    <name>F9W8X5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1794</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_43970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001235">
        <property type="protein sequence ID" value="CCD13661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_43970"/>
    <dbReference type="OMA" id="LRHNTRY"/>
    <dbReference type="OrthoDB" id="717268at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="517" mass="58007" checksum="5527F31AD14FE223" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9W940</accession>
    <name>F9W940_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_44380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001257">
        <property type="protein sequence ID" value="CCD13730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44380"/>
    <dbReference type="OrthoDB" id="1665610at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394786" evidence="6">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="7">
        <location>
            <begin position="110"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="107"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD13730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="45909" checksum="ED3EE9DA35B4EF31" modified="2011-10-19" version="1">MSFVLRLVITVLVAMPSRGTASRMYNVAEYRALCSIYRVVLKHCGGREENYVSTKFNWDGVAGMLNDVTELTAETSGANESSDEAQTESGVRGLVKSVYAIRLNATAAFTASRLKRLKDRIAQLKKEAEAKAKQAIGELKKAAGSESALCKSRSTQVKVSMNYNRSNICNSTSKGGEAGVSLVTDLLCLCASGEKNNQTCGFVIESGIGIWTDSDTKVNDEMWQKISRNCLAQKVSDELSMRNLNILIDRFHKLLGAQVVKTVHENEQRRWFLGHAGSLGGNCSGKEEDDICVNYARSDNTLDTIAWLDHVTTARDALVALESKVSLAEQLERQAMQIKDMFEHEISVLNISDDGRGAQWALGPLRTSSERGGGDGDTADVTSAEAFESSAEGRSVRGPALILFAEIFYQLFVLRCTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W988</accession>
    <name>F9W988_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 1834</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_44800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001280">
        <property type="protein sequence ID" value="CCD13779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_44800"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394620" evidence="4">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="80"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="355" mass="38585" checksum="3E86FBA7C4B1A061" modified="2011-10-19" version="1" fragment="single">MMKLFMVCLVVMGSWVGEWGVMANGEVSVVQGDNVKPFELLCKIYNVAQNPPIKPVDIKEYQKIVDDINALRAAANGKEGVNTQTEASRSAQTQLIGISQEAHKLLDEIKKANPEGEAEKARNTFNKVIFGKNGEYGGLCHGALKGVEEKRITACGEPSESKKGTSAGKNLILDFFCLCAQHNLPDEGIDNVCGVSVGSGDGAGWGTKLQLADIMCGEVKKGCERFAKQGVTSTQDGYSLYHKFLAKVKAGGKVKVNNSESFQKPGMLGTAVSATVNSNFHCNGKKTVSTSRTNFGSGSGVCIFYGNQNWKENIDWLEKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9B1</accession>
    <name>F9W9B1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_45030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001290">
        <property type="protein sequence ID" value="CCD13805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45030"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="23099" checksum="E9FEE458CB279440" modified="2011-10-19" version="1">MFFYVEFSFPHQFPLTHLPQPQGITMSESPSSPSPEGMAQEEIQWSMEKDVVEVLLKGIGKPEGINLYRFLEPAYPWMHSYVSRFSIRDFTRNPWRCVGEADGREKVWQHFPRLLWKFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETEPDLMEGMVWVVCRMPPQVRGVLEAPYPIGCTGPIPMPSPEEPGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9D5</accession>
    <name>F9W9D5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1850</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_45310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001297">
        <property type="protein sequence ID" value="CCD13835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_45310"/>
    <dbReference type="OMA" id="ICANDCN"/>
    <dbReference type="OrthoDB" id="876878at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="PTHR11743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29387" checksum="5D58B4E72E590288" modified="2011-10-19" version="1">MFVPTKTLVLYKDFHKDAKDLLTKNYSSSGKWKLESKFEGPKDRLIVNPTVTSDGVLTTDLEYSVSKCGAAFKASYLPTTSDITGTVTYQRRDHKVEGVASKGGKYEVSHEGNIHGLVSVHEKLTNNLLEVGLSTAVAPHCSVGCGAAYRLDGKSGCDWTAACRYARPGYTAAVRTNKLLTYTTSVTARVPECPHRVVLGAEVVCGRGQAWTGVLGVEVDCLVVKGNVLKARLNKELDWAFSYIAKLVDNWSVAVTVDKRLKPGFLITHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9E2</accession>
    <name>F9W9E2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_45330</name>
        <name evidence="2" type="ORF">TCIL3000_8_8240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001301">
        <property type="protein sequence ID" value="CCD13842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC92594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD13842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15847" checksum="060249A78540F4DB" modified="2011-10-19" version="1">MKRCRLLRHPITVGLNKTATTNFPAQTLFNFCFFVCFLSLFPFTFLYYLHLNCSATRSRRAIWDGDCASLIFFVLSHIEAIAANVTCWLSSPFFLFFSFLFFLSSYWKASHVGAMPRDGAFVFYLFAITFFHILLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9T1</accession>
    <name>F9W9T1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1891</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_46700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001342">
        <property type="protein sequence ID" value="CCD13986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46700"/>
    <dbReference type="OMA" id="RIMEACC"/>
    <dbReference type="OrthoDB" id="1245460at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="581" mass="63557" checksum="EEFB405249AAEA35" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9U1</accession>
    <name>F9W9U1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_46800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001349">
        <property type="protein sequence ID" value="CCD13996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_46800"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="32"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="355" mass="39418" checksum="20E2CC1521B918D8" modified="2011-10-19" version="1">MGKGDEVYHNVNERILLCEVLRTASRVLNNTRVSHKKELEEAIYGSNSRARFKKDCTVTLKGACASGPLNGRSVFCKYFTRGHVGQGGHGCFAESLFGTFLCVCAPGEKEAGVRNLCGVSVTEYDGKTWSGSWVKDNSDQEEVLFKRVLDKVREKCIEESQMESDETEELGNLKKAMEAFKRKIEAEKDRGRGYFYLGGNGKTDCSGKSGKDICAAYQMDKMDNKAEIPWVGKIERALSYLEKEIAKAGTGSSVTTTAQFSPEEFIPPREPVESAGPPAQNGPILYKTKDQPEKREPETEIMVSTESLKGREKPSTKRSTTTSPITDIPHLVTTPEEESLPIIMPQWLFLIGLYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA01</accession>
    <name>F9WA01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_00540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001367">
        <property type="protein sequence ID" value="CCD14056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00540"/>
    <dbReference type="OMA" id="RCRAHAS"/>
    <dbReference type="OrthoDB" id="1328081at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="PTHR22811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="SSF101576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388885" evidence="8">
        <location>
            <begin position="35"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD14056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28027" checksum="13EE88E3424B6F3D" modified="2011-10-19" version="1">MPTARVTSDQPPPSRLAVLVLLFMTLTPPQLTPAAAFGTKVEPGSRDCFVESVPAGATIAFLFRVTNGGSFDVDAVMTATTVPALDFHGRVSLMHTNEEFFSMRENTTTTVVNEWRRATEGSQTYTAPSVGVTHHGLPAEVTVCLDNGFSRRSPKWVEFQFLRHDAADAGKDPREGSKRAEEEVEAELHKHGSVLFELATVTERLRLVGEADQVKLASLIRIIQAGLVGNLVLLAVMAVYQHRALTRFLLRCAPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA37</accession>
    <name>F9WA37_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1926</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001382">
        <property type="protein sequence ID" value="CCD14093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47600"/>
    <dbReference type="OrthoDB" id="490757at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="197" mass="21871" checksum="92E8DC727B3C6447" modified="2011-10-19" version="1">MPGYADAWRLSGAPAHHERTINTFARHKIDSQTNFFYFVPNDEQEDLNETAPGTDSVTCGTATIRPSEGTDALVGTRVSLFDPSPFPDANHSNNNDSGRAIPLTSAASAGGTSKPSSFSVPQVAGRFQRCFFRSLSSRHHKKEYPLMRRYARKQLLVLRPFTEVTLSEREARMYNRGGDYRAHCSASDTYPILVLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA58</accession>
    <name>F9WA58_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1940</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_47780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001397">
        <property type="protein sequence ID" value="CCD14114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47780"/>
    <dbReference type="OMA" id="SACIRTE"/>
    <dbReference type="OrthoDB" id="974127at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1285" mass="141640" checksum="6091C34A69B85C86" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAA2</accession>
    <name>F9WAA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1951</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_48180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001409">
        <property type="protein sequence ID" value="CCD14158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48180"/>
    <dbReference type="OMA" id="WITRNET"/>
    <dbReference type="OrthoDB" id="1660565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="495" mass="56427" checksum="B4091B32761897D7" modified="2011-10-19" version="1">MTRKRGRRVRDEMEGEAVAPVVRTPTRGEVTTATVAAVSYGYAVRPSSTWTLDSVVEDVLMERYSRLNGMRLHDFLMEHFSETFGSPSVSTSVFMDDPSLCVSDDSVLRWITNSSPYREFVEEYKMEYEICKAMREGVDRLSARGIFSLRQWARADAANEVKGITLRVKGMLNAALYRVRRNEEAMRHVYAHSVKELDGVYDSVFNARWSYVVRSDEYSKKWLGMSVLRVGEGEQPHLWSKAQADIKPDPDPEEPWEGDVVPGVEGKLVMAVLSSQKGWPYGFFQRDDVPEEKVDMLTGYDAVGDAYVRKENLRVWHIVQENIDAWSSGVGDVHPFIVIGTPGIGNSFATGSLLLYQLLHYPSEDLNVVAYFVRGKAYLFHREERRVVHYAEEEISRCEVEGMARRGVKGYMIYDNSDNGIDISVGSCRSSWGIVLISPPNVKVFHEFTKQLQHTLPIYINCYEDVELKAVLVWERQSQLQNNQIKLENVNLGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAA9</accession>
    <name>F9WAA9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001410">
        <property type="protein sequence ID" value="CCD14169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05120"/>
    <dbReference type="OrthoDB" id="1714258at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="17966" checksum="9E2EFDD0BAD7F5EA" modified="2011-10-19" version="1">MLKTFASEVVFPVPLGLVFRLLWRHTWRQPFRPSRGLGEPPPVMGVPPTCRCQNMSSHLLPHHGKWYDGSLPGSVRIRCSGQRCGERGKGHGDGFPDVGALLRVMSTSAEFPPAMAVVQGSRRASIRGKALVVKRVWATACSRPISSLLWVVLRKAFLTSRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAL7</accession>
    <name>F9WAL7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1988</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_49270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001450">
        <property type="protein sequence ID" value="CCD14287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1726478at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388912" evidence="1">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16698" checksum="F501B743480F50A4" modified="2011-10-19" version="1" fragment="single">MNSKLPAWILLNLSIIWTGEGNNVAKNVREFNALCRLFRIANDNRAKKTDEMIAGGVDWGEGAALYAKISEAENKTSPSADTPVELTMGDSVVLRFPSREPLGRAHNLLVVSRKRIEPLKDQIGKLKEQTRQAANGVLVNLKKALSGDKMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB01</accession>
    <name>F9WB01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001509">
        <property type="protein sequence ID" value="CCD14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50430"/>
    <dbReference type="OMA" id="ERIPMEY"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="816" mass="92795" checksum="1E798A90E52672A0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB45</accession>
    <name>F9WB45_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2059</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_50860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001529">
        <property type="protein sequence ID" value="CCD14476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50860"/>
    <dbReference type="OMA" id="NASRECA"/>
    <dbReference type="OrthoDB" id="1636835at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390085" evidence="1">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="309" mass="32623" checksum="4ECE4DE6CEEBCF49" modified="2011-10-19" version="1">MMALLAYIVVAAIATLGTDCAQVPRSLSAETPEAPTPQIITPTCSLLQQLIGVPLVDIAMRARAMNLAAETLNASRECASDVWTAEGNIKFANKVLCEGMMRAGANSVHIIAAESALVAARIELKLLLRAAKHVEHAGLVVSGQVRALLDKGTEAVGKANEAVAMLTAVATQQDTGNENTTVEPVCERRAARNVTSSSLRGALLLVESTMVLQHALQKSEEVAALINQMEVANAEAVQAMHGVHKARLVAKGAEAVVAARTKTVYVEVGRTIQRITLNDTVIPQLESLEHAAGVPVFFVLPLLVTVALH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBA2</accession>
    <name>F9WBA2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative clathrin coat assembly protein ap19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_51410</name>
        <name evidence="7" type="ORF">TCIL3000_3_2650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="HE575316">
        <property type="protein sequence ID" value="CCC89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01001552">
        <property type="protein sequence ID" value="CCD14533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_51410"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_3_2650"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="1307450at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="PTHR11753"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SSF64356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007659411" evidence="5">
        <location>
            <begin position="22"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Clat_adaptor_s" evidence="6">
        <location>
            <begin position="52"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCC89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23596" checksum="AA63426ABCD19D66" modified="2011-10-19" version="1">MLFLSFLLLVFLSLSLPGVFGRGKYNKEVVGIKGQAGVEGKKGSTPAHRGPMIKYLLLISRQGKLRLAKWYVSMPKKEKARVVRELCQTALGRSAKFSNMLENRGSKFVCKRYASLYFIACIEKNDNELAALEIIHHFVEILDRYFGNVCELDLIFNFHRAYFVLDEVLLGGELEDTSKRSILKNIEVHEAAAEDPEISRASGAAAGRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBM1</accession>
    <name>F9WBM1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_52530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001598">
        <property type="protein sequence ID" value="CCD14654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52530"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="35"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD14654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="41835" checksum="13AFEC9BB2B2598E" modified="2011-10-19" version="1" fragment="single">FLWRKFSILWVETKHSDKGGFLLCNVFKAATGVLRNEKNKPQLKDAIYGAKGGTKFRDDGSIETRGNCVGTLSGRSVLCDYHKNSGRVGLGLGKNGCFAESLVGTFFCVCTPGDESTQGLCGLKEFGSVGTWSGRFSGIKLNETLFKDVWKKLNKTCNDDSEGEQDYKKQLENLKTATEAVRKRIERSHVSGFFLLGQGTSFPCSGETNKNICAAYQAKGGKPYVPWLDKIELVLRDLIDATAYINSAPALEAPRPGTTEQNRENEEAALVMQIGENEEAQGPTVRFPHIQMETDNQTGDKTEKGGLTGNKGGYSRESTQRKERKPQNFQKKKQYSASCNRHQRRRLFPNTSYSATLISLAQLTNMQSTHNIPTDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW6</accession>
    <name>F9WBW6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2154</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_53410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001635">
        <property type="protein sequence ID" value="CCD14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53410"/>
    <dbReference type="OMA" id="KENARVW"/>
    <dbReference type="OrthoDB" id="1654555at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="809" mass="91272" checksum="13AEDDC378FC62B9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC98</accession>
    <name>F9WC98_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2202</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_54610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001688">
        <property type="protein sequence ID" value="CCD14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_54610"/>
    <dbReference type="OrthoDB" id="611294at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="662" mass="70618" checksum="9C8DC1493055BF13" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCE9</accession>
    <name>F9WCE9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2221</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_55100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001709">
        <property type="protein sequence ID" value="CCD14942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55100"/>
    <dbReference type="OMA" id="KNMAFIH"/>
    <dbReference type="OrthoDB" id="561986at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="194"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="319"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="415"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="764" mass="84577" checksum="4E6AB890542D7F67" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCL2</accession>
    <name>F9WCL2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_55720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001736">
        <property type="protein sequence ID" value="CCD15006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55720"/>
    <dbReference type="OrthoDB" id="1709699at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="181" mass="21408" checksum="F840871A7F084BCA" modified="2011-10-19" version="1">MSFNTITSPRQRPWSMEKDVVDVLLDGVTYADHVNLYWFLRPVLACLPVDLVIFTLRDFVRNPRHCIPESNVCDSLWQYLPYILWKFRLSATPLVKHFGPTQTWTKWHWDSWKIYYDMDDMPLEAIDEEIWSRCRRPPPPPYQPCQELVLVEATPAFIQVPYSTIGYLVHMPVTPRAWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCV7</accession>
    <name>F9WCV7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 228</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_05770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001777">
        <property type="protein sequence ID" value="CCD15105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05770"/>
    <dbReference type="OrthoDB" id="1696298at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="260" mass="30326" checksum="90319DEF246BA17E" modified="2011-10-19" version="1" fragment="single">MRNGRYYPLLLEKRSTIGTVYQSAQRPFKMQKARSTGLLRNGEPALRQHPRVGQAQLLVQAEQDVHVLHRLARSALDQVVDHRQHHHQVAILRTMHRNTAHIGTTHAARFRMATGRHHIDERLIGITLFKQRLQVYRAIGDGRIQRGVNPADHRCQVRHEGQPHILAGSATQTLADFRQVPMTFYRIGFHAFRRFGVKRTYRRTTARTTDARLAVRDQARRIRQASLQQWQKAQLRRRRIATRHGNQARLLDLLAIDFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD11</accession>
    <name>F9WD11_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001799">
        <property type="protein sequence ID" value="CCD15159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05840"/>
    <dbReference type="OrthoDB" id="1672061at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394684" evidence="5">
        <location>
            <begin position="20"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="55"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38358" checksum="7F129FB125B41406" modified="2011-10-19" version="1">MMKLKCLILVVMCLVVSNADENKKKDHNHDAHNALCDLMKAAVGKWGEGGAGLSDPLKKALGKTLFGKESGWETVETLKTVPKDYSTAGGLREYMCGQPSHEKAFFDNPHQVRWSGHSSPHDMVCLCTAGSHGWPVNESSQKDTLCGKYGSILKATKGKGWDSENEEKGAEHGGEQIEATWKEIVKQCLDEDGKKGENLKEALNKFINALVEKPGDPAHPTRTQLGEGTPNNYTGCTGSSTRGVCVMYYPKDKHATPWWLVLDEALKEDEQIQKQRAEEEKRKQQQEAAKKDTNKTEDLKSTTPITNQTEQNKKENITDKLRRLNPTSGTPISRPSSWLLSAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDA3</accession>
    <name>F9WDA3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_05960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001844">
        <property type="protein sequence ID" value="CCD15255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_05960"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390177" evidence="5">
        <location>
            <begin position="26"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="54"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="299"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="368" mass="40151" checksum="4F5183BC5A1BA1C2" modified="2011-10-19" version="1">MTMKTFKYVVVLWSIVFVEFGKVTGESGYNIEESKILCDLLGAVEDVRKNIILREALKDSLKDAIYGSAHHNALIEGGGRVVKSRSCGKSFFGRGVFCNHKRGDGCFAQSLIGTFLCVCTPGQINRDRSLCGVGVQRYGRTTWSGGFVVSQNTQALFEKVFDKVIKNCNGGSQNNQGNAEKLKQLRSALETFNEKLKPGTISGKIFLYFGGKNKTSGCSGLSETDLCAAYEGYGDGSANVNIPWLTKIRKALEDLEAVERARTNVIHTQTQKGAGESNEGVASHDAPNAFLVQNESVFEEAGDQPAKNEPKSENTTTAGSPEEQPPKRKKRNIATSPFTDIPHVASDPNEDHSFIIQPFWLLLAALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDI1</accession>
    <name>F9WDI1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2367</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_58640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001872">
        <property type="protein sequence ID" value="CCD15335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_58640"/>
    <dbReference type="OrthoDB" id="1704729at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="193" mass="22019" checksum="1B252EA9810E5336" modified="2011-10-19" version="1">MCSSRRHHRDRLTRGVEKLRLVGISEEQLQLGRQLCNQLRITQTVKGRHGVGIEAMRKAIEYPHKKRRHVFIQAALKAKRQQIDVPLNRARCFTCGRVWHYSTSPAVHSRRNQTATEKQRLQAPEAMASVAFNILFHTPQVNQKGGSHMVEHSWRPSELHGMDGESMAITSGQVRSSSTAWGLSRELGEIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDQ1</accession>
    <name>F9WDQ1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2387</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001894">
        <property type="protein sequence ID" value="CCD15405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59320"/>
    <dbReference type="OMA" id="FTICIAP"/>
    <dbReference type="OrthoDB" id="725565at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007498">
        <property type="entry name" value="PqiA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04403">
        <property type="entry name" value="PqiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390220" evidence="2">
        <location>
            <begin position="29"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="599" mass="64972" checksum="16A125E84C3DF6B6" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDS0</accession>
    <name>F9WDS0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_59460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001903">
        <property type="protein sequence ID" value="CCD15424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59460"/>
    <dbReference type="OrthoDB" id="1672819at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394696" evidence="2">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="338" mass="37711" checksum="8B61A33C8FFE7EDF" modified="2011-10-19" version="1">MMMKCWVLVMMVMSVGVCADPSGTKNHNGEEHKALCDVLKAAVGKWVRERESLSEPLKNAIKQTIFGYGGPEVTVDKLKEKAPKDYDDISGSRGLSCAQPFSDDIHKAWPLRWSGHSAPHGLVCLCTLGENGWPISDAKSEKLCGQTKDALGGDKAKRGWSDKESKHGKGGEEQIQATWTTVIKECLSNGREEDLRGALKAFIGKLNHTWTTVYENMYLLGEGNISSDQACNGETQVCARYLPNATETKTWWQDLKNALDEEEVQKKREEEERRKQQDEKQNLEIPKTEDFKSGSTTTNQTEAPKNDNLTEKLRKYNLTSGTPISMPTSWLLSATILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDS1</accession>
    <name>F9WDS1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_59470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001903">
        <property type="protein sequence ID" value="CCD15425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59470"/>
    <dbReference type="OrthoDB" id="1666016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394905" evidence="5">
        <location>
            <begin position="24"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="27"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="83"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43635" checksum="F58EA9F22A142519" modified="2011-10-19" version="1">MMKLFMVCLVVMGGWVREGRVMANGDVSVDGNDNSQYFALLCKIYNVAQYPPIKPVDTKEYQKIVDDINALNAAVNGKERVNTQSEETKSAQTQLVGITRDAKKLLEEIKRVNPEGEAEKARNAFNKVIFGKNGKEGDLSQGALEVVPSRMAACGGKTQGKGTSAGKNLVVDFFCLCAQYNEDDVGVDKVCGVSVGSGRDSGWGTQLVTSDTMWGEIKQGCEKFDTQGTTSTQTGHFLYREFLEKVTAGGKIKVGSSENDRKPGMLGTAVSKTEKNNFNCNGQKTLTARHSSPSGSCVFYGEQKWEEHIAWLKKFKEGLQLIDKLNTETASWQHQLTTLLNRARELYEKVKADSQQEEENTDDSPLAQHPNPDENENADSSTQSQRHSLLAGALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDW8</accession>
    <name>F9WDW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2413</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_59910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001923">
        <property type="protein sequence ID" value="CCD15473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59910"/>
    <dbReference type="OrthoDB" id="1716673at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17665" checksum="60725FBB53F26C9E" modified="2011-10-19" version="1">MWARTTWKQKGCIMRRFYAFAGRHELLAGQTTVRLFYHKFAACKEQCNSAHEDTAFHIGCRALASADVLSGVVLIGRWRPHKTGSSRAALGARFRLQHASTRAGWSGVTAGMWREMAQPRNDNFVPHPKDKDAIVIDWEGIERRSKATHTELWGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE95</accession>
    <name>F9WE95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2448</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001962">
        <property type="protein sequence ID" value="CCD15601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60870"/>
    <dbReference type="OrthoDB" id="1657483at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="591" mass="66765" checksum="1D7571DC061413A3" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEA4</accession>
    <name>F9WEA4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_60970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001964">
        <property type="protein sequence ID" value="CCD15611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60970"/>
    <dbReference type="OrthoDB" id="1672016at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="80"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="355" mass="39330" checksum="6782C5DE2A18E5F4" modified="2011-10-19" version="1">MEIWVLKTAMMVMVVMVVMGIHAVGEEIVLNTSHFGALCNITKAATKLWSAANGQAHLFDKMEKITQIIDGIFFGLNCEASSGGIWNFPQNFIGTNPKRSAICGSKDTSAHVPSASDALASTILCLCTPTTEDKKELCGYPVDGHGKWSDSESEDVEELFKKVWGDWEDGMFVKNCIHYDTYGDFEGAKKNLTAEVESLKITLEDEKGVILGQKRTTCGVSDVCANVNRNPAWLEKLEILIENTKITIPLMVIQEAPREKMPKSESMDTLLPIHEPTNINTHTSPTAREDHKKQESPKYPENQPEAKAQPEPDPARKATEIPRKREDINPVSEANETSGCLLTSKKWLLLCLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEF5</accession>
    <name>F9WEF5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 259</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_06800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002003">
        <property type="protein sequence ID" value="CCD15662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1664052at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394940" evidence="5">
        <location>
            <begin position="24"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="93"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="434" mass="47213" checksum="D63153D7F8D50B34" modified="2011-10-19" version="1">MVCLMNVLLAVVVICSIVKDAAAQGAQVQGVDNIEPFSLLCRIYNVAKNPPINHVDLKDPSEIVKDIDSLNASLAEEKQFNETEHVGNSSGAQPKSTITREAAAAQALMRRITRRAHTILEEIKKRNVTSEIEKIKAEFNKVIFGENGNESDLFHGALSGVTERGAACGTPGTWMKGNSAGSNLVVDTFCLCAMRTDDGIENVCGVKVGGKSSKPDNHGWGNTVVPLGSSSMWASIKKECGTLLHQHPKSTGEGEEILEDFFLKHLKSGGLYRWGSTKTVHGSGRKEGMLGTGVGKNDDDPESGLFCDGRRGKNGGRTVGRNGENTVNPGGVCVYYGPESEWRNIPWLMKFKSALSSLESVNNQTDTIQRDIEKLQMLLHRAEEIYETAKVILEIKQSVLPTNLQTAVKKLTAHNAALSHHIHHFLAPWVLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEH7</accession>
    <name>F9WEH7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 269</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_07010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002014">
        <property type="protein sequence ID" value="CCD15687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07010"/>
    <dbReference type="OMA" id="PEVCGAS"/>
    <dbReference type="OrthoDB" id="27356at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1309"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1915"/>
            <end position="1942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2073"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2131"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2694"/>
            <end position="2721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="2818" mass="306432" checksum="8A948B17E8856E4D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEI2</accession>
    <name>F9WEI2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 270</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002015">
        <property type="protein sequence ID" value="CCD15692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07060"/>
    <dbReference type="OrthoDB" id="1683794at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="358" mass="43285" checksum="2981B3E9D5F28113" modified="2011-10-19" version="1">MQKNSSNSEITTKNTLFRTKNKKTKKIFFLHFFIKILQKVLFHTGNAKKQFKQRNNHQKHTFPHKKQKNEKNIFLHFFIKILQKVLFHTGNAKKNSSNSEITTKNTLFRTKNKKTKKIFFLHFFTKILQKVLFHTGNAKKQFKQRNNHQKHTFPHKKNKKTKKIFFLHFFIKILQKVLFHTGNAKKNSSNSEITTKNTLFRTKNKKTKKIFFLHFFTKILQKVLFHTGNAKKQFKQRNNHQKHTFPHKKKTKKRKKYFFCIFLLKFCKKCYFTPGMQKNSSNSEITTKNTLFRTKKQKNEKNIFFAFFYENFVKXCYFTPGMQKNSSNSEITTKNTLFRTKNKKTKKIFFLHFFTKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEM8</accession>
    <name>F9WEM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 290</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_07510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002037">
        <property type="protein sequence ID" value="CCD15739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07510"/>
    <dbReference type="OMA" id="TYTLFAH"/>
    <dbReference type="OrthoDB" id="572061at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="411" mass="44814" checksum="DC86EC8D1E6E1F5A" modified="2011-10-19" version="1">MSNKQHLYSDIEEGSGSWPAGEQGFDTLLVHGGVKPDPVTGAVLTPVYQSTTFVQESIDLYQSKGFSYTRSANPTVKALEEKLCSIENGEYATVYSTGMAATTTAISSFMSVSDHAIVTECSYGGTNRACRVFFTRFGMEFSFVDMRDLSNVEKAIKPNTKLVISETPANPTLVLTDVAALSELCRSRGLIHMCDNTFATAFIMRPLDLGADVTLISTTKFVDGHNMTVGGALVTNQKELDAKVRLTQNILGNAMSPFVAFLQLQTLKTMSLRVVKQSQNARKVAEFLETHPIVDRVVYPGLTNFPQRELAERQHAGGYHGGMLWFELKGGTPAGRRLMDTVQRPWSLCENLGATESIITCPSVMTHANMSVEDRLKVGITDGFIRVSCGIEEANDLIAALKKALDSLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEU1</accession>
    <name>F9WEU1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002062">
        <property type="protein sequence ID" value="CCD15807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00890"/>
    <dbReference type="OrthoDB" id="1716674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17353" checksum="A15CD54A7DC8E608" modified="2011-10-19" version="1">MQSLSRGCQGGAALLDVSDSKQHCEMREEWDNERRGAEGGVKVFDVTTRVPWLQAGKVAVSQAYFFSLFTMCACSRQCLAWAGHPTMGCLFDIRKGDDRLLGGTCWAFGEAESDGGYFVTRSLEDKSCFSRWYVPAQRVVRSVEPLCFFGGRHESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF95</accession>
    <name>F9WF95_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cell surface-expressed gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_09490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002117">
        <property type="protein sequence ID" value="CCD15963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_09490"/>
    <dbReference type="OrthoDB" id="1683977at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="306" mass="33669" checksum="CEAD65CCB903A444" modified="2011-10-19" version="1">MHHHSVCQCGKLLPHTRARTCLSSCNCLIPLILPHAVAENTTQETMRFFSGAALSFFVLMLHAADVGNAFPAWGRSPICIEGLKLLKGVEDRFSEKLKTYALAINSTESLRAHCERLMEVVGPTADANDVRSRVKALKRFYVEFVKDQSVAAELREEVKRLVQDIKRECGSWIRFILGSWGIKNDVRQKLADGDRMKKELEKHVSKINNMWAAVNSTGCSVEYYDRLLEQYKRKHGPSNGTGGQPAVQEPANANVSSESTESAGSGGSTTGGSNGTAGVDGVTREGSGVPSDSNNDTSRYWSRYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFC7</accession>
    <name>F9WFC7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002126">
        <property type="protein sequence ID" value="CCD15995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="111" mass="12731" checksum="03BCF856F4C9F490" modified="2011-10-19" version="1">MRAYYTGEEKCTNPWYPQRRRPAVVLEVQTHNIPISCDHHHPPLRVHRGKWVAMAWTTPGIQEDTGSLHAFTQESESLTYAVRHTLPTLRISCSTEGTGCALRPRNPLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFD1</accession>
    <name>F9WFD1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_09710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002128">
        <property type="protein sequence ID" value="CCD15999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="ELNEHKI"/>
    <dbReference type="OrthoDB" id="1564069at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PTHR13303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="116"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD15999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15800" checksum="A002917549754F92" modified="2011-10-19" version="1">MATNKPAANSPTEEEVALRYQQLRQESLSLVSRVSELENELHEHRLVAEALKPLDGQRRCHRLVGGALIERTVAEILPELMENIKGIEEALAQLTKMLTEKQAAMEEYARKHGVAVAQRHGQNPVGGSEEAGKSANADSRGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFH6</accession>
    <name>F9WFH6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 386</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_10160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002144">
        <property type="protein sequence ID" value="CCD16048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10160"/>
    <dbReference type="OrthoDB" id="1698696at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="24836" checksum="FA839AA664DD4B09" modified="2011-10-19" version="1">MLHNGQIVGSLCLVAIPKSGTFALSTADFAKVWPSTASPPMSFALYHLHSSLSVLRVSTLCSQPKCFEVPVRNCANSDSPRRSSLVCFGAGRTWSSSTLRCVHGIGPSSKALYISFRTCLSTPVTMSVIHAGYICGLAFPCSAALSAASFRGTPPCENTNWKFTDTQSRTSRKVRPQIRLSIASSTTTGPVLNAMSSDNESVNATTRVLCVWFNSITSTSLFNPASIATLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFJ4</accession>
    <name>F9WFJ4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_10320</name>
        <name evidence="2" type="ORF">TCIL3000_8_6890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575321">
        <property type="protein sequence ID" value="CCC92462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002153">
        <property type="protein sequence ID" value="CCD16068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC92462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16776" checksum="D0CFADCAC2530B1B" modified="2011-10-19" version="1">MWHAQKGHMARIVVRNSLSYSILLRSSKVSGHSVPILLSYQLRERGIRFTGVRETFFWIAIVVQPCPILYWPLFGTQVFIGSVKGASLAIFSFRRVSFVLYLDHPRRGTSGRVTLHPLPTSTKLDCCDSCPILERVKCGNGDGNAHINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM0</accession>
    <name>F9WFM0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_01260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002163">
        <property type="protein sequence ID" value="CCD16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01260"/>
    <dbReference type="OrthoDB" id="255547at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="723"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="867"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="961"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114072" checksum="E26E1B68492B3241" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFM6</accession>
    <name>F9WFM6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002164">
        <property type="protein sequence ID" value="CCD16102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10590"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031929">
        <property type="entry name" value="CLP_mid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15984">
        <property type="entry name" value="Collagen_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Collagen_mid" evidence="1">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="15077" checksum="6CA4951CB4D85462" modified="2011-10-19" version="1" fragment="single">MLGDTLSTASTTGPLGSLTNTLGSKVVVPVVSLVENTTGNLGNATGLGTPLNGVLDKVGSTVTSLGTQVASTGGTGNPVTGVVGTVLTGVGGTLDKSGGYVAPTGGTSAPGIPELVGGLVANVGTGLNVGNTNGTVSATGVTGGAVGGTVASLGTALGGTGVANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFN3</accession>
    <name>F9WFN3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 408</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002168">
        <property type="protein sequence ID" value="CCD16110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10670"/>
    <dbReference type="OMA" id="MITYEWS"/>
    <dbReference type="OrthoDB" id="1581848at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19352" checksum="C7FCB3D5FB051B71" modified="2011-10-19" version="1">MSTSCRVRAAVPGDIEVMIEMQKALAMETEGLQLDEAAVRRGITAPFERENIARFYVAEEVPDSSDGAGGAAGSRPPKIVGAMTVTYEWSDWRGCHILWIQSVYIIPSWRRRGVFRKFFDHVHRLVMEDPAFAGMRLCVARNNENAINTYKRMGMTVENYHMMKLMKGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFS8</accession>
    <name>F9WFS8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 423</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_11070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11070"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394742" evidence="3">
        <location>
            <begin position="23"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="579"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="707"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="717"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="732" mass="83856" checksum="D3E7092A9A8F56F8" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG61</accession>
    <name>F9WG61_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 469</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002236">
        <property type="protein sequence ID" value="CCD16295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12350"/>
    <dbReference type="OrthoDB" id="1668723at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20421" checksum="FD93C1B6FCA7B2FE" modified="2011-10-19" version="1">MEMRGGCGMMMSMDECSVWWIIEGLFFSWTAEPCVSSNYPRAIPTEAGESICSLSRKLKDVSPWTVWQLAELRKTRNVYASKLLDWQLHFHGSPACELNESILEDIQAALKKVNEEIFKLPAKAIRAGALAAKSAGRLDEFITVFANAKMRKVFDTSNYCLGSGGDPAKRRDLIDCFPFGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG94</accession>
    <name>F9WG94_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002248">
        <property type="protein sequence ID" value="CCD16328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12670"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="20083" checksum="A6D34BA59B42EF62" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQERPWSMEKDVVEVLLEGLGDPEKINLYRFLQPAYPHIHSYVSRFSVRDFARNPWQCVGEADGREKVWESFPRLLWQFRVLALQLVYYAGPPESWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQTRGFLEAPYPIGYTEPIPMPHPPEPGPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB9</accession>
    <name>F9WGB9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">WGS project CAEQ00000000 data, annotated contig 487</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_12910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002256">
        <property type="protein sequence ID" value="CCD16353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12910"/>
    <dbReference type="OMA" id="VNSMANF"/>
    <dbReference type="OrthoDB" id="35986at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0407">Ion channel</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="7">
        <location>
            <begin position="547"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="780"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1379"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1730"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="1408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD16353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1766" mass="194505" checksum="B8326B4EDC0C7203" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGG0</accession>
    <name>F9WGG0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 498</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002268">
        <property type="protein sequence ID" value="CCD16396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13200"/>
    <dbReference type="OrthoDB" id="1695112at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="233" mass="26503" checksum="A57F1BFEFA1DB6DF" modified="2011-10-19" version="1">MLFRVIFSFPSPGALQNCFSNNYFMSFLVFRHPARCKTVLATVISVSFLVFRHPARCKTVFATIISCRVIFSFPSPGALQNCFSNNYLMFFRVIFSYPSPGALQNCFCNNFSFVSFLVFRHPARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFHHLARCKTVFATIISCFSVSFLVFRHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGL8</accession>
    <name>F9WGL8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 515</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_13760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002287">
        <property type="protein sequence ID" value="CCD16455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="132490at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394765" evidence="1">
        <location>
            <begin position="30"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="32219" checksum="2DCB4BE3D5BB23C1" modified="2011-10-19" version="1" fragment="single">MAFSYCISFLSNWFAILFFLLEKGDNCRCGNGCFQGLEGREMLQSTCRAGFALQTRSAWRVTNFLRASRGTDVNGPSDGVYIETIQFPCFVGARTPLRISLPRSFVDIPPPRQWCSSLHASLAAAFEKLRREWLSTASISVNTIHTSRSRGNATFVGVSGRCRSTCSYLFSTVSPIRSLLLRETTPRLTVCPAMPLHMVRRHLSEEPTLQVETSETLTGSAAQMCGIRWYASHSRRSLIDLECLRNLCDEPSMLRCQRRVLLVVGFLISAAHGPKDAGSATEVLNLLPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGP7</accession>
    <name>F9WGP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 524</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_14030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002298">
        <property type="protein sequence ID" value="CCD16484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14030"/>
    <dbReference type="OrthoDB" id="1717165at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25054" checksum="AFB5F26AC81AFC70" modified="2011-10-19" version="1">MSISAVHILLVVLLFLNLSSLVLLVFALVRYVMARLHRNDEQEDTREVDTAVNRQNSVGNIAEHAGYYGEAAYSTRSAAEWPFDYAANVPQWVMQEMHPARLAALERGGMPHRDVRYCVPLPALLQGDGAAGRLNNANAYRSDINAVHTDVFYAAGPHRARPRYASCLGAMVGEATDISSSDGSSGDDDSVATQPARCYIAAVALHTPPTPLSDAASFPSSPDSDVLLSARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH36</accession>
    <name>F9WH36_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_15340</name>
        <name evidence="2" type="ORF">TCIL3000_11_4690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="HE575324">
        <property type="protein sequence ID" value="CCC95063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002368">
        <property type="protein sequence ID" value="CCD16625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000.11.4690"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15340"/>
    <dbReference type="OMA" id="NNHRTVA"/>
    <dbReference type="OrthoDB" id="445162at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="242"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="362"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCC95063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="496" mass="56190" checksum="B45ED776E307FAE9" modified="2011-10-19" version="1">MSSGETTLNLFLAACKKEGVKQPNTHLIDFFSKFPDPYEIEEIDLSNNYIGNRGILAVLDVIRQLPSFRFFNCSNQKLYNTDLSEDSVKGNETVDRIVELYKVHPTANALDISNNPISNYAGRRLLVLVQTNKKICRVELKDTRVDFELRSRITQQCEKNTIALWEAQAEPDEECAFGEGAVWIPSHTPADLTAIGGGKNRRQTVRNEGIDPEKAKSFVPASFPKTDEELALITKLLTHNVLFSFLNSKDLLTVAKAMYRVTFKQGDCIMVAGETTCDKLYIIQDGKADIIKEGQKVYLKVEGTAVGELELMYETPTVATVKVCTPELIAWALDRDTYRYLVMGTAIRRRETYIQFLNNVPFLSGLDQYEKLQLADALSTSEFAPGDYVIRYGEEGEWLYIIMEGVVEVIGRDSEGKPERVWEFRHGDHIGELEFINNHTNVADVVAKTHVLAAKLNRRHFEMCLGPIIDVMKRATLEPKYTYYQNVLKEVMKAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH49</accession>
    <name>F9WH49_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 594</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_15470</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002374">
        <property type="protein sequence ID" value="CCD16638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15470"/>
    <dbReference type="OMA" id="SEKGHEC"/>
    <dbReference type="OrthoDB" id="1527547at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018342">
        <property type="term" value="P:protein prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="417" mass="46071" checksum="90D4C2E5C7A8AE37" modified="2011-10-19" version="1">MTSSWVAEEISKQLQSVLEEAARHFVGGGSISCSLALLPDAFLHGMPHSWGTAEIINQPQGGVCELVVGIDTDLLKKSLKDFLCGFQHMEGELEGSLPPVATVAKRLSRAALSLLLLLMPAHGSLWNELRSRIKRTRTIGNGGDYPIIVQEFLFTSLLLTFHHKTQEVWVYRLWVVQQLLSADEADVQVLNRHDQAVLLEAADKHHMNYNAWNYRRQAFDLLIATVESRGENQTGTLVAPLLQREVDIVLRFFESHNGDCSAVSYLIFLLHKSEAVGNGTSRGSRISSGCKGSRNGVGCTDSLANAVWANLLAATARELRRHYDKGHEVVWILRLALVQWALRTLPACGWTLQDEIDFATTYMELPVSHEDLDGLAVAWSAGSGCASWTQLHAARYGIELFKLIAAAQTRCLVCSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH89</accession>
    <name>F9WH89_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 614</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_15850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002396">
        <property type="protein sequence ID" value="CCD16678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15850"/>
    <dbReference type="OMA" id="ADSEWRL"/>
    <dbReference type="OrthoDB" id="1029814at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36093" checksum="DE51CC2F8A48764A" modified="2011-10-19" version="1">MNAIFDAIDRNDYEALRRMFSSTSINEVNSDGYTPLYYACMKKHVNVETIDEILKLGAQVDLKGADGETPLYVACFNGRRDVVMLLLENGAHVDTINGRCGESVLHLVSRTGDSTLLDFFLSRGADLNARNMRKETPLFVAAKLGFHEIVYRLLRAEASPDVCDMDGKSPLYIASERNLKHITILLKSGDKDLALSKAAADEFLQSRPARLKTTEEICDEAVLRGGEHKNSIREVPKETKPLDIIDIVIPRPKGNLSNLLGAKPKGPCLSLEDVGFDAPPVIPPSLRNLPPVIPQRIGGTMMRIGTGINAIGVEPIRIDTVPSDTMNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHD0</accession>
    <name>F9WHD0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_16280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002414">
        <property type="protein sequence ID" value="CCD16722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="132" mass="15022" checksum="8A3D5136EE229477" modified="2011-10-19" version="1">MFFCVIFSFPSPSALQNCFCNNYFVSFLVFRHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSVSFLVFHHPARCKTVFATIISCFSTSFLVFRHPARCKTVFATIISCVSESFLVFRHPGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHL4</accession>
    <name>F9WHL4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 665</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002454">
        <property type="protein sequence ID" value="CCD16807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17060"/>
    <dbReference type="OMA" id="TRHEADY"/>
    <dbReference type="OrthoDB" id="161359at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1077" mass="120636" checksum="A669A7C3B444D180" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHN8</accession>
    <name>F9WHN8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002465">
        <property type="protein sequence ID" value="CCD16832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15081" checksum="CC4739476D9A1C03" modified="2011-10-19" version="1">MKKHGLETPKEREGEIFFSAQLASFLKELFKPESPWSPPLDSSELKQTRAVRRHRSPTVCDTLLLPPSAATKLIGVSDARNLRKRPRAVDSLSKEVFFESSLDEGRTGLLWSSAIYRGFKNHRGSRQCRAARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHV9</accession>
    <name>F9WHV9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 698</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_17870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002490">
        <property type="protein sequence ID" value="CCD16904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17870"/>
    <dbReference type="OrthoDB" id="1721249at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17921" checksum="C7CA078E78FC55CE" modified="2011-10-19" version="1">MHQRATRNRQGMGGGSNSRNMEESDAAVGEQQQMIKRCNLPGMLFGHDAQTVSLSEKMILRSRESPPLEKETVEQVECVVSRMIYAVGVRVESPSSYCFPLKIVRWRLSRPSRGLACPSDPGVLPENALILAKMRMKSRLKAYQWPRHKSCRQRPHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHW7</accession>
    <name>F9WHW7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 699</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_17950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002491">
        <property type="protein sequence ID" value="CCD16912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_17950"/>
    <dbReference type="OMA" id="PDYPYRV"/>
    <dbReference type="OrthoDB" id="448120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PTHR11362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="503" mass="57174" checksum="DB435CD4D8E7D1C9" modified="2011-10-19" version="1">MHRCISNAPSRLLPAWTLRFYHMPGWKTKVSTKDVRTREQREADRKARQIEKLPRPQALHDFQYPYEKTVLSDTMFQYPVYENELDTPHLFNIVEPPNFFVYWNVFDFERTSYPPVPDEDHRLLLPLPESDAWRNHRTRSLKYLRKHEILPNYLPNVRQDVNLSVVFPGVYATRARRCDETGQTLPPPPPVLEMTRRNFWMTAHCGNYIELTDLQHPPSIFFIDVSKVASDEEEANSPDGSRESGSWYTLIIASPDYPYRVPSTVDGHTERGFFLNYMVVNLEGGNATLASHEAVAEPSQPMGGGPTQVGGGSAAPARKAGVVVASYVPPLPTEDAGTTRHICMLFKQSAYISDVTRALSDSAADFGARANFRLHATRREDISASAAVLARVEQTLPPEPSAITFFQTKWDIQVQEFYESRGLPEPALPVDSEIENILAFHSRKPSDLRVRARHRPDGSTVVGDDPNFWAQKEPTRMMDGFMQGLWSRRTMLGKNGIPVTYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHY6</accession>
    <name>F9WHY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 707</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002500">
        <property type="protein sequence ID" value="CCD16931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18130"/>
    <dbReference type="OrthoDB" id="1727910at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17661" checksum="FA9F8CA4786AE6FD" modified="2011-10-19" version="1">MSVQRRNEASGKPTHQVASTPSTQHQPGGTKDNELEEILQKAFKFWEDVCLVDFLTQECEKTHGACGPNVALAAFLEVPSHYIEEDAEREEVVEKFPQKLHHLKGFIFRDVPFLRAVGITTRGQWAYRRLTRDAYSSDQLHSFICVWLSSRRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIA0</accession>
    <name>F9WIA0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 753</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_19040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002551">
        <property type="protein sequence ID" value="CCD17045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19040"/>
    <dbReference type="OrthoDB" id="1735452at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17300" checksum="09B958C73BC2EF74" modified="2011-10-19" version="1">MRLRAYILATIPYLHAHNVRTLQYWPVKQAYELFDDVPRRILEKAAQDTRQWPVSPFPTLINSTSDPDDLESSSDSPTPEGSVSPDDPCSTRTGLCSAGSKTFSRMDVRSWSTCRSPITSKNVASASMKRACPQPIFPSSFKAQLSTSSVREGGSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIH4</accession>
    <name>F9WIH4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_19700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002592">
        <property type="protein sequence ID" value="CCD17121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_19700"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389172" evidence="5">
        <location>
            <begin position="24"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="95"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="347"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="422" mass="46602" checksum="A689232461E87D31" modified="2011-10-19" version="1">MEFFMNAIAVAIFTCSIVKDTAAQGAQVQNNDNSEQFALLCRIYNVAKNPPIHHVDLQDPNKIVEDIDALNSSLYEEKHINETEQVENSSDVQLKLTTTREAAVAQALLSRITQKAHTILEEIRKVNATRNIEKVKGEFAKVVLGEMMNESHLCDGALKDVKDRATACGNTGHSSKGASAGKNLVVDFFCLCAMRTDNSRQDKDGIENVCGVYVGSSKKNGNHGWGDACPVTSSTMWASIKKECGKRLQHYPKSTKDGHEVLEDFLKHLELGGVYRWETTGKESSRKAGILGTGVASEKEGKNILCDGKKGEKNGQPPGGVCVYYGPSDWGNNIPWMVKFKTALASADALNNKTATIQRDIDKLQKLLRRAEEIYHTTQVITEIQHPAVPKDFQTAAKRLTAYNAAWRQHPYAHSILLFVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIY5</accession>
    <name>F9WIY5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 848</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_21150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002657">
        <property type="protein sequence ID" value="CCD17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_21150"/>
    <dbReference type="OrthoDB" id="1661590at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="485" mass="52412" checksum="E4AF4E70E8E8BD80" modified="2011-10-19" version="1">MLRQASFVDNEISFCSIGFVAGNNCHPFLLGNNIHHNNFLGILLRRGSKAACCRCKVVNNSWAGLYAAPHSYGAFAFGEIRSNNGLCRPENDASSIRCFAGFAFTEKADELPTCFRESSELEEEAYGSISSTLSSYGDIVASGIGLICKVISCPSSCFSLADTAFPSGFLEPGPSFSGEAPEHYDWGWAADGGIGVWITLGSMTDVSDTLIEGNRNIGVFFSFGVESHHKNMCKFILEDCEIPEIPGGETVNGHSVKTYEQNVQRLLFTTNDVCIHQSYLLTEAAPNGNASGDHKEESPKAASTPRDVEDEFLFSPLLLSRPPTIRSNTIVRNGCGAYIQLTQPLEAEPVAQVVEPVQPETPPPPPKVRKRGSVAGKSAGNATQSGLPAIRKNKVAAPRKQKNTEEEPVSACTPEPKSIWADILPPHMLSEVVIPAYAVSVQENAIYDNLNFGILCHHILELHCGDFIARRSEIGVAAKLTMLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ79</accession>
    <name>F9WJ79_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 882</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_22060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002694">
        <property type="protein sequence ID" value="CCD17383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22060"/>
    <dbReference type="OMA" id="CEGLEAN"/>
    <dbReference type="OrthoDB" id="1666893at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="420"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD17383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="477" mass="50453" checksum="CEB597DED3B2F328" modified="2011-10-19" version="1">MGETNVFKFLISSLFLFSLTPLLTVVGDRKVAVRMLRVLCVTTTCFLFALAAAAPITASGGAGYNGDACKLQNEGINALCYLARLVSRSYEVSEELLKQTGDAVRSDINLYGEQIQHRLSGVRASLEAPNEKHTLTDGDVRKIKDMCEGLEANNKKQRDRLRGALETYHETARQAKRESDFLLGKQVENKQCDQTDELLVVINCGKTGGEAGISRLSLETLCADSAVPEGVKEVAHHDTRNCPMVGRYRHCHGSMGAEIEGAMTKWKSIKSSACQHSDKWEARAKNLTSIMKSLDDLTNTITNATLMSGVYAGAAQRLQTALQYGHSLDDIIERVKEAGKKGAVIELPSGGTSSGDSATGAGGDKIGGGDGGAAAGTEGGSSSSSGSGGRAGTTTLEEDVDLGLRLDDDAMPSSVRVGTLGVWLLATLVPLFVIFIGVVVFCLVRRRGQAADVNGKNSAVTGTTMGKGSPSDARGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJF4</accession>
    <name>F9WJF4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 903</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_22780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22780"/>
    <dbReference type="OrthoDB" id="1663029at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="501" mass="55947" checksum="7E68150C1F9ECBBB" modified="2011-10-19" version="1">MDMKMRMMVGMMGLAKSLGAALGKDENATTCQLDLKEAGALCALETALEMTQTQAEKYEKLYLKESCENMTRVKSHFDRHKSSLERLLSQLEKKKKYKAVEQAMFGAVIHEAAKENDRWHRAFEESRTKSLWRMEKIRQTFKKALGKKGEDSGLNCNENHSTLSHFIRCHVTGGSNGTTPDTTSTLGTVCEGQDYRQHLKEGAGDKNIETPLEAAWRRWSGLRGEKESSKRPACPSTTVWENSILFVTQHMKELAEMAQRAEAATNQSVAYLSTVQTLHHGLQGNECIQKIAQDAMEAATPGALVTLDEVHGRTVEHPHPYSTTSLRVQMQGTMERLQSLQDYAERENQRCSALRKKLFVVLAGLAGVFTVTTFSAIGCGFKCKERLKTKYKKKKDVFLSFFTGLFVTAFCTTAILAAIWLPESRASGPFYYALLVVPIVFFLGSVLVVLMRRRQWCGMEVKLLPYFALVGGLVASALSATAVAVFLLSKIYRPSPCPCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJM7</accession>
    <name>F9WJM7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 930</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002747">
        <property type="protein sequence ID" value="CCD17533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23470"/>
    <dbReference type="OrthoDB" id="1705838at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="180" mass="20462" checksum="CFB0A4FD1539E927" modified="2011-10-19" version="1">MPKALDPYHAPLPCLIILVGGENVLRHRPRAPASLAGVPEDMHTHSVRSVQPSFVVYGHRSLRQIAQAVRVASPVVRGVLTLFHDILPKVVEQRVVASTPLKFPDHVPCFCPWCTLYNFLFQTVMVWRAHTQRLQIDFPQKHHQPGSSREDSCRNIRQACGVRMAFGKEADHRHLTFHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJX1</accession>
    <name>F9WJX1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 962</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002783">
        <property type="protein sequence ID" value="CCD17631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_24370"/>
    <dbReference type="OrthoDB" id="1702071at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="253" mass="28712" checksum="13655EF100CA2035" modified="2011-10-19" version="1">MAEEKLKEVNEKADEAELKVQECGKEVLQKARECWKKVQERGVSLLETPDFQSLEQALTNKPWEPRPEEAEALATVCKEFRNWKNARQKVVACEEAVNKRFQELGEALHESEETCPKFPLSDRGLEEVSEGSEEAEIRFNKAKKKLGTAKKKVEAANRKAEKAEGELKGAQDRLGEKKKAFQRANREVTPREKAFGVARQRRVTTARAYLQASHRRPALEQLRHLLNRVPNLETLRNENPAVDTAPSSPSDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WK71</accession>
    <name>F9WK71_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 994</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002818">
        <property type="protein sequence ID" value="CCD17732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25160"/>
    <dbReference type="OrthoDB" id="1683838at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="254" mass="28154" checksum="9C8DEB04F2A953C8" modified="2011-10-19" version="1">MHHRAHNKTPARWKTCLNLLPFTSPSHSAHFPSSRPPEWGWSVKENQWREMRGRRAEKCRGPHRHREEIAPARPFPHCERYAQALRPPVAKEGLKPQQRREPSARNCLLVAPWPAAVQGVLLRPLSCPVEGVGEPNSAPLSGGHPREQLPLWPSGVAARLEAGLSTRGHAKATAHRIKHFSAVAPQWHKAFVLALLNTLVGCACRPLRKREKIGSSGGPFSKLVPVRIEKLREPPGLSPTRGAAPSQRSLTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W368</accession>
    <name>F9W368_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1010</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_25470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000363">
        <property type="protein sequence ID" value="CCD11576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25470"/>
    <dbReference type="OMA" id="VVERINM"/>
    <dbReference type="OrthoDB" id="1101862at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="SSF47473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="772" mass="83780" checksum="4251A0EE07CD0EF9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3B9</accession>
    <name>F9W3B9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_25970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000390">
        <property type="protein sequence ID" value="CCD11629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_25970"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389749" evidence="5">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="39"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39126" checksum="8BE1B8771F3BC94F" modified="2011-10-19" version="1">MWRNVLVLVVLIEVYLESGMANDQAGYYQNEMEVLCNLYRALNRVLKKYGENEPLRNGLVSAIYGSDEGNTLFESDGNIKKLAWRCRDGRTNARALLCSYKSGKGCFAENLLGAFLCICTPGNNDANQVCGVSHLGRDNTWFGWQDARRKEALFKEVWGKFKEKCTDQAGNSLTGAGDLETLKSALKNTTGKLRDGANGFFYFGGTGDGGCSGSSGSDVCVAYKREGTGVSVVWADRISQALVKLEEAESSAKAATIASAQQAVGSTQDLGAVVENEKSSEATTQTAPAPRKESKAVKEEEEPGAQVTQIPRNHKNASKKIEKRNSPLSTLTNIPHLASDPNEDGSLLTVPRWLLLVVLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3F0</accession>
    <name>F9W3F0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1045</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_26260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000401">
        <property type="protein sequence ID" value="CCD11662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26260"/>
    <dbReference type="OMA" id="HRPSTWI"/>
    <dbReference type="OrthoDB" id="704215at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015232">
        <property type="entry name" value="DUF1935"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036310">
        <property type="entry name" value="Smp-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09149">
        <property type="entry name" value="DUF1935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101601">
        <property type="entry name" value="SSF101601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="255"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="786" mass="89071" checksum="378D03724B313B6D" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G4</accession>
    <name>F9W3G4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1050</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_26400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000407">
        <property type="protein sequence ID" value="CCD11681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26400"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="SSF57667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD11681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="287" mass="33591" checksum="4936E0F4B3F9FB61" modified="2011-10-19" version="1">MSVEAKSEERGEVELPQSEDGAAEWEEKMERAEEMERLHREGALDLSWVWEAYDAFVKLAEKITELLDDSKRKPEEEGQQKLDDKMLEGLENKMREGLTKWPEYYEKKKAYWRRRLEEPKNGTGEEVVEKELKGQEEQANKLEEELETIEENLAEILEERTTPETGAKTGQARSNSKCPYCDRRYASAGWLKRHVQKEHKGEPDPDMDVGRVTFKCPHGCGKTYKTQGWLNRHLREKHDEQSGSGEVACDSDEDCVKLRCPYEGCNKTYKKMGWLRRHIREKHPDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3G5</accession>
    <name>F9W3G5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_00160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000408">
        <property type="protein sequence ID" value="CCD11682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00160"/>
    <dbReference type="OrthoDB" id="631276at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071076">
        <property type="term" value="P:RNA 3' uridylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="371" mass="41493" checksum="171326C0CB33E0B3" modified="2011-10-19" version="1">MRRLLTFHFTKVGEKRGITLPWSSCLPDVGDKRWVGLGKSIVKLALASDTGRLAFDECNIVRQQLETLVQSVGYDANVFAFGGLVVMGLLEVGGDADFVGVADVEPGALEAGEIVSRLSREMRRLGLKSASLPRARVPVIKVDRVSKSLPGTSLHHLSTCGLFQFTRQLNDAECSSFKSRMKENHGAINVEWNSNQQFSTVEFKSTSELVAALTEVKRHEGIDIPLRLPVDPRNGPEIYRLPFDFCFSSVGLRNSYLLSEALSKYVFSRHLLLLVKKWGRSSGVINSIDGLLASYAFTVMCTHFLIKVGVIPKISALRSTDEPQLLPFFPEYRSLHKERGVHGRTWFLTAAFFEYTGASLTMRKAWYVRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3I7</accession>
    <name>F9W3I7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_26590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000416">
        <property type="protein sequence ID" value="CCD11705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26590"/>
    <dbReference type="OrthoDB" id="170905at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394537" evidence="5">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="43"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="344" mass="37785" checksum="EE12C5D0A11B6AE4" modified="2011-10-19" version="1">MWRWLLLVLVFVGGTSLAKENNEDIFEKLCYIAGNVSVLMKKDGEAKSTLDKALYGDEEGTRFKEDGTFTADGCGLGHIMRNQLCSHMPGGYPPLGGSDRHGCFADSLFGTFLCLCTKGSNREQDLCGLSNLGGVGSWTSWRGDDHEQNLFKAVWGGVKQKCFKNNTVDMETLKSAVEGIKGKGQQQNGKYYATLGVTNTNGICTGTNPGDACVTYPADSGEPKIPWADKILKAIEKLNKTHNQAKSIYSATTDFQHQDDHDDHSDDPEDSNNDDHGEEEEVEESGENPGSHNASNPSRPKKKRSKKPSNKSTKKTREALKDILHKNDGSFLPQPFWLLSAFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L3</accession>
    <name>F9W3L3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_26870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000433">
        <property type="protein sequence ID" value="CCD11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26870"/>
    <dbReference type="OrthoDB" id="1664868at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="476" mass="53433" checksum="605085D98458C0FC" modified="2011-10-19" version="1">MTIKRIEQERLRKKSQEEQEEMQKTKIMNTMQLLILQKENQDKTDDIMDEEIYGLIRAIRKYRTNKEAGEKIEQTIQSTSEKDNKGNTVKKSTYPTEKIRKQQEEQKQAIRINETSTTKKDEQKQQVQQAKSAAHTKTNETNVSKNKEQYATIQNKTQEKEKTPPETTPTLRSSDEELAAHWTVFSEGVGVTAAAECADDESRGRAALHSEWCEGWMSLCSCAVTDTESVWRQCILRSSDEELAAHWAVFSEGVGVTAAAECADDESRGRAALHSEWCEGWMSLCSCAVTDTESVWRQCILRSSDEELAAHWTVFSEGVGVTAAAECADDESRGRAALHSEWCEGWMSLCSCAVTDTESVWRQCILRSSDEELAAHWTVFSEGVGATAAAECADDESRGRAALHSEWCEGWMSLCSCAVTDTESVWRQCILRSSDEELAAHWTVFQKAWVSRLPLSALMMRVAVVLRYTLSGARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3N1</accession>
    <name>F9W3N1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_27010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000439">
        <property type="protein sequence ID" value="CCD11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="103" mass="12214" checksum="179A7B6922BDE3CE" modified="2011-10-19" version="1" fragment="single">SCFYSPTIFNYLFLFHLLTILFPYFLLSVFFSYLFTCRSFSGVVRQYFYCDYLSVCLGYSAVKSSQWALLFTYFLSFYTLILFFSHSLLSSLMCCRSPKREKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3X8</accession>
    <name>F9W3X8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1125</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_27960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000491">
        <property type="protein sequence ID" value="CCD11856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27960"/>
    <dbReference type="OrthoDB" id="1715944at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17269" checksum="E41F3DC8E29DC395" modified="2011-10-19" version="1">MTWLPISLKNAAKCDKWYQLQNHHIAQSLNANGAWEKLFRVIPVHATFSVSTNKKTTAALFFSLPLMMSRVCGVCAVCSRDVLESGVRRVYVPSSPTNISCRQEGESPVCVLWCCYVRVKGCMCGMCVEVWSLWHEGCVWVSFVGRRALAFCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W405</accession>
    <name>F9W405_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1133</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_28260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000500">
        <property type="protein sequence ID" value="CCD11888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_28260"/>
    <dbReference type="OrthoDB" id="1739571at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD11888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16921" checksum="67F7046FA50D3C4C" modified="2011-10-19" version="1">MSHRRHCYPFRGVIYLAFRSFPRVLHRSKQRTRARSLLSKAKRLLSRRLRADKLCPHRYSPRPFAFSPHRDFGKPPKYVTLACGTFLRELLTCNAGPTACQSNVSPLLSPTPNTAVVSGEVELLQLLVSCTHSALQHATVQNYQGGHSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4G9</accession>
    <name>F9W4G9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1180</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_29800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000553">
        <property type="protein sequence ID" value="CCD12061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_29800"/>
    <dbReference type="OrthoDB" id="1707208at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389792" evidence="1">
        <location>
            <begin position="24"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19935" checksum="10486BBE6F4946B2" modified="2011-10-19" version="1">MPQPRRSLVLITSSVLWVEEGNALCVGERAGLGIIVKLHINSNRGVYYWKRGLLRITTTAEVGEASEKHPSRTSRHLAEAYGICSLVCADSPGDGGYLDMVPEYCSRPLGGSQAPALLPVQQDWRRYEARGYQRSRQHKWHCGSDGVVRLPLCTLDVLYFKCSDFSCFLARMSSKDLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4I7</accession>
    <name>F9W4I7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1187</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_30000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000560">
        <property type="protein sequence ID" value="CCD12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30000"/>
    <dbReference type="OMA" id="RSFREMA"/>
    <dbReference type="OrthoDB" id="1524649at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="1">
        <location>
            <begin position="115"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="290" mass="31723" checksum="1B6E25AB5C6D9ED6" modified="2011-10-19" version="1">MTLLSLRSCGSLLVMHMGKAPTGAHRRQNARLSINFSSILVRFPLAIEVRLEGAAEGKQSEMRALLAGFVLGIGAHACVCGGHSYGSSLYVSPLPENPNNSLVFVDIVRCRAGVLTAHRSAAGRVTIELFDHTSPVSTTNFRELCRGRHGKSGTGHDLCYRGTRLFPDKHCITGGDVTFGLVPGGWSIYGKQYRETPRKNNAKGAGLLYAIGEHSHLGSEFVIGMEGFTPDREHVLLGQVLEGYGALQKVQQQCSRPCATHFISYHISDAGVLREAKTPNYRRGWRFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D1</accession>
    <name>F9W5D1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1313</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_32650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000700">
        <property type="protein sequence ID" value="CCD12382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32650"/>
    <dbReference type="OrthoDB" id="1728738at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18402" checksum="1D7A6BAED95B2297" modified="2011-10-19" version="1">MLTCNARTLAQCHNSVKGQSGRCKREVLVLHWPRTASSARRREPLPPLTNNSRRGRSENRWCVFPPTSFLALPRNSRSLIRSIIYLYIYSATISSYFSFPPPLCLFHLSQTPLLHLRARCHLLMQGALNIIMSMMAAVITTETIMYMRGKEPAHRCNAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5D2</accession>
    <name>F9W5D2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1314</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_32660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000701">
        <property type="protein sequence ID" value="CCD12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_32660"/>
    <dbReference type="OMA" id="KCRQAQQ"/>
    <dbReference type="OrthoDB" id="987514at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39807" checksum="0DB63FDAC55503ED" modified="2011-10-19" version="1">MSEFTRNTVDESSVCDTTPKEPESEGPLESFHSIRDREQLEVDARAAVLELLSTKGNTFVQGLLQAEIQRVKKLESNVASIKKKITAISKAVDELNASILREAVNKEKKEKKCLFFREEIERRGATAVRAAKAMEAYRNSIMEKYTKKFDEIRAESDEHKQHAVELMEENRRLTEEVAQRKKEFDESSSSYESDCARRQEYVESIIRSYRQAANDVETLEARLTTARQERQALEERKASLEEKVMRCSEAVPNLEGLNFVETSEQEAKKNYEETETRISQLEEEKRDITYTRIALDKETVSWRAALASHKRELHRLEKSKFAAENKCRQAQQKAGQKGAESKAGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5I7</accession>
    <name>F9W5I7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000718">
        <property type="protein sequence ID" value="CCD12439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="119" mass="12878" checksum="4852EF09EE9579F5" modified="2011-10-19" version="1">MKSACNKWVALARSHRTHAWPSLLSSLPHYTIGGSICCRGVQPKSAGITHPSLLPTLHMPFSAASSIQLLTGISHGAVAQPAVQHSNKSHSELLIFDDHFSQSHSTAHLQALMQSHFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5K4</accession>
    <name>F9W5K4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1336</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000725">
        <property type="protein sequence ID" value="CCD12456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33350"/>
    <dbReference type="OMA" id="HRWFKHA"/>
    <dbReference type="OrthoDB" id="1298641at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389901" evidence="1">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="274" mass="31879" checksum="03C4B05B4BD73D35" modified="2011-10-19" version="1">MWRFGSCCRRSGLFYVLAAPIHVATPSRWCSQKNSTPVAECAEQAGRADGIVAAVSQQEPFGEDMFPAGFDELEAASQEIHDLCYAMINYLRKVDPDETKSLFEKRCARHFRDPVPESKRRLLHGHNSRSLYRRNCYRTKKEYQEATGLFLQFGEKLLLLLTKPVMQRIIDSAGKGCRDHRNDGVHKYRNVLERGTWRGFPHRWFKHAPFEVQQLRADIPEATVANTRAMRDRSTINSLFTLMEPQHPFRSRLEDHLFEITKEYDPVHKTERNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5M7</accession>
    <name>F9W5M7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000738">
        <property type="protein sequence ID" value="CCD12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33560"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20205" checksum="1AEACB21F048970C" modified="2011-10-19" version="1">MSESPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCRMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5R5</accession>
    <name>F9W5R5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1362</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_33900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000754">
        <property type="protein sequence ID" value="CCD12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33900"/>
    <dbReference type="OrthoDB" id="1148913at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="342" mass="36851" checksum="3EEE2DD95790D830" modified="2011-10-19" version="1">MPGECVGSTSATGVSDLSTLQSFLNACELMPLVDKVRLPGTPPASQLGKFHLCCRYGNCVARFTVSSILRIRNGGKGHSPLFTLEGNFFRDGCLLVDVTTVSLLAAGKTFDELFPHATISSVSISSLVQLVDVECIAGDSDDVVASGGASTGDAHKGSAYNLLLSRGEVSVIFHHSPLGVHFPVDTQSGAVYDSLITTDLCVMYYPLGSTAAPLSSSGAENSLPSVTIRRFTHLPSTWEQSLERDDTLKHNALYHFTDWVRGRVPCAVCELSGFRCAQLHQEDVGMSCRTYVVPLTGAILVVRWETPTQEWERYLPLLQNFVDTLHLEDPSGSATALNKGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5Y1</accession>
    <name>F9W5Y1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_34500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000796">
        <property type="protein sequence ID" value="CCD12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34500"/>
    <dbReference type="OrthoDB" id="1663705at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389913" evidence="5">
        <location>
            <begin position="23"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="45577" checksum="6654537E6884C95A" modified="2011-10-19" version="1">MMIMKIQLWMIVCFMVMGVVRAMVSRGPRGRPYRDGSDFNGFHYDYLCDVFQATAELWEASMKSQKVPNDELQGALDKALFGNYGKRDIQEITETLPDDYKQLRNRKEWCGSCKNSERYYPGRSITHDLMCLCAPGYYGEPFYIYYWSFGWYYEETGYKLCHKGRTEMVNNQYEGWYAYKGYGQNKGLEKSWKTVVWGCLNNRKDKGVLGGQNIEEKLKKLNTTIWNFTGILRHANGRHKLGGYDDHYTASDGSDEKRIHVHYDTCDQLKKPWWKKLKEALEGKTETQLLVDNSTVKKTQEPLAPPPEEKGETMLTAGDDVPIIPPDNEVPTGDPTTPEEEGNGTQVMTPSDGLSNTSTNSTGPTIRAMEGNHSAHFQYLRSSTTITRPLCLLSTSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W613</accession>
    <name>F9W613_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1411</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_34780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_34780"/>
    <dbReference type="OrthoDB" id="1685777at2759"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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            <end position="54"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="108"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="142"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="251" mass="28770" checksum="CD8560C190FECB1C" modified="2011-10-19" version="1">MVVRHCSRSHFIGQCGHWSVWCIVRVIATNSSFIFLVACARVPLKWVLLCLYALPHLARTKSLPFSASMCRPILRRFLCLHPSTFTSASCTPFSFPVFTHFALFLYVGKLGPRRWPLRPAVVWMFLLHVMNQHFVVILFAAYEALVSGWLLQFSRVILTPIGLLHALVSGAPCYALHMLTPWAFYCFLILVNILTRIRSLVNDVVFFWLSLLSVCFASTCLFSLPYDECFLQHQRYFSLTLSAFSPSPYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
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    <name>F9W666_TRYCI</name>
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            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1428</fullName>
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    <organism evidence="1 2">
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            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000827">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1705836at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="20252" checksum="9B266A416C35AE33" modified="2011-10-19" version="1">MNFPFLLWCFSLEYSWRCGVKIYFLRPLQYGRLVWLDGHFDCVARMLYFLQFGIYGMLWGKHFISSLCVLSLPHLHSSVTLNGSAVCRLNYWFQPSFQWSICGISSFFGCLPQYALHVCFLLQLLSFRWRCATAPPRNAVEHFRLQCSQVGRPSYLRSRTPFWRGDRPQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
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    <name>F9W6A4_TRYCI</name>
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            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1440</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
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            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000841">
        <property type="protein sequence ID" value="CCD12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35660"/>
    <dbReference type="OMA" id="FHKARCD"/>
    <dbReference type="OrthoDB" id="581880at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
            <begin position="688"/>
            <end position="750"/>
        </location>
    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="241"/>
            <end position="274"/>
        </location>
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            <end position="314"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="888" mass="96815" checksum="02E0E10DD0C2D76A" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6C4</accession>
    <name>F9W6C4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1447</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_35860</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
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            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000848">
        <property type="protein sequence ID" value="CCD12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_35860"/>
    <dbReference type="OrthoDB" id="1363966at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="621" mass="66551" checksum="66117936EC97B5C0" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6N2</accession>
    <name>F9W6N2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_36800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000897">
        <property type="protein sequence ID" value="CCD12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1580233at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16323" checksum="A383D06D70227BD7" modified="2011-10-19" version="1">MCAMLYGNTFPICCGNLDYLPLRLSNILGPHKLGRSGTGIRGKFTSIWTTCHWKPSTRRSGVGAGGHHLYLNTSPTRKSFWSKQRRLSSKCRIPPWGISFIFHFLPEHGLGYRICQFYSHDEVVLKKTVIARNASLFLDFFGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6S3</accession>
    <name>F9W6S3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1516</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000925">
        <property type="protein sequence ID" value="CCD12880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37190"/>
    <dbReference type="OMA" id="ERIIMNC"/>
    <dbReference type="OrthoDB" id="1531237at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="803" mass="91787" checksum="FCBBE4B96657B887" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6S9</accession>
    <name>F9W6S9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1519</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_37240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000929">
        <property type="protein sequence ID" value="CCD12886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37240"/>
    <dbReference type="OMA" id="CNETESC"/>
    <dbReference type="OrthoDB" id="649145at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor_I29" evidence="3">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Pept_C1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD12886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39866" checksum="57DEB6F0CA9E1153" modified="2011-10-19" version="1">MPRSEMTRTLRFSVGLLAVAACFVPVALGVLHAEQSLQQQFAAFKQKYSRSYKDATEEAFRFRVFKQNMERAKEEAAANPYATFGVTRFSDMSPEEFRATYHNGAEYYAAALKRPRKVVNVSTGRPPMTVDWRKKGAVTPVKDQGKCDSSWAFSAIGNIEGQWKIAGHELTSLSEQMLVSCDTNDLGCELGLKDPAFQWILWSNKGNVFTEQSYPYASGGGNVPTCDMSGKVVGAKISNMRYLPLDEDTIAEWLARKGPVAIAVDATSFQRYTGGVLTSCISRRLNYGALLVGYDDTSKPPYWIIKNSWGKGWGEEGYIRIEKGTNQCLVKNLPSSAVVSVPPPPPPTPTFTQELCEGAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6X2</accession>
    <name>F9W6X2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1532</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000944">
        <property type="protein sequence ID" value="CCD12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37500"/>
    <dbReference type="OMA" id="LTRGMIS"/>
    <dbReference type="OrthoDB" id="937372at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="40644" checksum="22689C47F9184013" modified="2011-10-19" version="1">MSLAGDNSSYAVLFRGARVASWVVVCGYGAALAYRFGFLQRALPGKAAAVLESTVEKVKARTEPLGDPVRLEAVRRHLMKVYGISSVGMLAAALGGAVFFSYPKIPITIPIAFTVVPAALLFLMPRELMFPECRTACFLTSSVAVGCSFGPVEWVAWDSLYIFGVLTASTLSGLCVPLLLTRGMVSYVLSSQLLSSALSVVTLTSVPSLLSGNGTALLQSVGPESVNVLLMIQLMANMGINVLHTLPTITRFVKWRGTDDELLLSVDPLKEAFCICGGTAYVFWRCSRWVYRTLMYAALGKSPCDGGGQQECAPSLFDRWRSAMWSHRACDVGASVLLVLCYVRAVSALQRGDTADVLEKLRACFARASPVSLITAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7G3</accession>
    <name>F9W7G3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1608</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001028">
        <property type="protein sequence ID" value="CCD13129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39110"/>
    <dbReference type="OrthoDB" id="1776817at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13427" checksum="9FC2AD3B89519524" modified="2011-10-19" version="1" fragment="single">MPLQARNLKRFPMFLTISRVLACYPIRVCEPFRAPRTHPPSLSLTGALVALLETFCFSLIISKRKHTPEGKKHKSYIQYFLLFLLKKYCFPSFSHHQASLISFFFCFSFIFSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7I0</accession>
    <name>F9W7I0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1615</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001037">
        <property type="protein sequence ID" value="CCD13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39250"/>
    <dbReference type="OrthoDB" id="1756847at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19575" checksum="5E9497F6BF1E9F91" modified="2011-10-19" version="1">MVVLMNALMRCFAGLFGRSFFPSFLFFLKISIHTIFRVYCSSIFVRDVAFTACLSNPNSFSFVFFVLLFPRRVFLPFTQRAKGGKRGGGSWWCDPGGTPTVLYRVIFHASLRDRTRAVAPAACLCACVCVGVFVWVTKTHFPRHASRVHEPFTFIQIYICTYIFLHLRGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K6</accession>
    <name>F9W7K6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1624</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_39480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001047">
        <property type="protein sequence ID" value="CCD13174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39480"/>
    <dbReference type="OMA" id="EMQHWDD"/>
    <dbReference type="OrthoDB" id="1186934at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22893" checksum="747B133ABB3575BC" modified="2011-10-19" version="1">MDVTDQVVLGDTDNNGRMLVTCHVLMSLSQRGGLKGSDVQTFSTEMLHWDDYREECGINDGTPSMKSTFQNSAEAPFDGILFSSTDGNVKALSLVVDPALSGSDVQNFCTEMQHWDDYRLDNNIRDGVQPMKDMFDVFSGHEMYILNAKDKLSKLRHMCVTSCRQSYGCDAQHRTSELVHWEEYQAMQSLDRTPKLDSACAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7N7</accession>
    <name>F9W7N7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_39780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001059">
        <property type="protein sequence ID" value="CCD13208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39780"/>
    <dbReference type="OrthoDB" id="1665574at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394597" evidence="4">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="101"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD13208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="420" mass="45898" checksum="8D83561CC54878F1" modified="2011-10-19" version="1">MACFVDVIAFVIFNLFGVASGQLEVAKDDNIEPFALLCRIYNVAENPPINYVDLEEPFEIVGEIDTLNRSLLEEKRHDEEWNSGNNSEASVKPIVTREAAISQLSLNQITQKAHKILEDIRKINVEEKIEKVKHEFNKVIFGDGGNESELEQSVLNGVGDRAVACGKSGLTEKGNNAGKNLVVDFFCLCARNPEEQGVNQVCGFYVGVKDSKIGWNESDLMGSSTMWASIKGGCGKHMQRHPKSTAEARHILGQFLKHLKTGGVYRWGNGKVDGSDRKEGMLGTGVGKENGNVGTGPVCSGKNGKGGNHPGGVCVYYGKESELDNIPWLNTFQKAIASVDTVNNQTATVQRNIKKIQMLLDRAEELYETTKVISEPQNPIGLPAAFLNASGNMTVHNATRTRSYSHSSHACFIPALVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7Q4</accession>
    <name>F9W7Q4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_39960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001065">
        <property type="protein sequence ID" value="CCD13226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39960"/>
    <dbReference type="OrthoDB" id="1675711at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394746" evidence="10">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="24"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD13226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="396" mass="42584" checksum="F5F6D031480FD7D5" modified="2011-10-19" version="1">MLTEPRVAWWLFLASVILLFSDVALGTGPKAIPTKAGAAICTLSKTLKDVTPWATQQVEDGAAKITHLEMKLLEWQSKFIQSKSKGSGSEECKVTGLLFRQVRKEINKARAEVEKLEKEASKAAAFAANSAGRLEEFITVFANAKGNDKYCLGNEKAATPGELKDCFSKDDFSEESLVDIGDRASEQEPNLATAIEGIKHQSLRDSFNGGSSAGCNLIKGASGGILGNTHLEKSLWWGGGILTIGKEFAGDLASGGNLIAGEITAATKDKATWTADPAKQVVHLKNASDAFKAFKAVQEKIKSKVESIEQKIQACIGGQESGENSTEQNTTEQTATTEQKTTSPTCFDNVAKIAADLKEKRALLARYQKLKGWIPPSNALNPRKATRHFGILLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7S7</accession>
    <name>F9W7S7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1649</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_40180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001074">
        <property type="protein sequence ID" value="CCD13249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_40180"/>
    <dbReference type="OrthoDB" id="377025at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="301" mass="33125" checksum="76A7352710B1FFA4" modified="2011-10-19" version="1" fragment="single">MSDHPDNIISTFDRIELLIADINAKFSSLHDQIKPNEQPIVMHDETLAQGQSSAAEFVKSVKLFDLSGQESTTSTLLDGSSGRRCHRHQCTSSLFSPSTTGKRCAERDLFIAANNLCTYLNGGIDYRHLCLKYQRMFEMLIDLIKEDVNMLRSVDPFSAGSIEEVIKTLRGIYLETRSLLEQHGIVTNPQSPALQENKPCGVSCGVEVNSGELTAPKTAEAPNDALSRHTSDGAGPINAVPSEVTTEEAARQRSPFERVLNGDVCSKPQVALKCADKERYSPLHFCNSRSRVVTNKGVQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W860</accession>
    <name>F9W860_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1708</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001139">
        <property type="protein sequence ID" value="CCD13387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41440"/>
    <dbReference type="OrthoDB" id="1736377at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16973" checksum="803A60D154DBA849" modified="2011-10-19" version="1">MFGVVTKNTYAYVQKFVFIPLEGNERRNVSVHTTRDQPDCIKYRSSMLGSLPISRSKRLCLSATLLSRLQISPPVQCYMDPTVLKYAVMAITLSRQANIVSESFSILLPIVFLILPCFPCATGACLGISVFNFNNSHVSSNDHLLRLIVVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W878</accession>
    <name>F9W878_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1713</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001146">
        <property type="protein sequence ID" value="CCD13406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41570"/>
    <dbReference type="OMA" id="TRYRIML"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25454" checksum="B262D37C703E5F3B" modified="2011-10-19" version="1">MPFYNTIALYHTMALYHTIALYHIIALYHTIALYHTIALYHTMALYHIIALYHIIALYHIIALYHTIALYHTIALYHTIALYHIIALYHTIALYHTIALYHTIALYHTIALYHTIALYHIISLYHIIALYHIIALYHTILLHHIIALYHTIALYHIIALYHTIALYHTIALYHTIALYHTMALYHIIALYHIIALYHIIALYHTMALYHTTSLFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-06-02" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B7</accession>
    <name>F9W8B7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_41980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001159">
        <property type="protein sequence ID" value="CCD13449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11484" checksum="3ED8D2DDD791EA0D" modified="2011-10-19" version="1">MREKRPGHDESLRPQPRAKPKRKTTRSEAQAQDEGKWVDGVGRCVGMRKGHGSVREWVATRKVRRDEIMCVEDAIARISSGTRLYGTQPRLTTTLRQGNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8E8</accession>
    <name>F9W8E8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1731</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_42290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001165">
        <property type="protein sequence ID" value="CCD13480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_42290"/>
    <dbReference type="OMA" id="FHIFFVP"/>
    <dbReference type="OrthoDB" id="406738at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027121">
        <property type="entry name" value="VPS33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="PTHR11679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679:SF1">
        <property type="entry name" value="PTHR11679:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="SSF56815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="595" mass="66297" checksum="F43B9FE0480E2D86" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8R4</accession>
    <name>F9W8R4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 1768</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TCIL3000_0_43390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001206">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
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            <end position="230"/>
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            <end position="745"/>
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    </feature>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD13600.1"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
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                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
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    </reference>
    <comment type="caution">
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            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19786" checksum="B92B161240464390" modified="2011-10-19" version="1">MQREADRLKRKKDEHRDEEEFGIFHFSDRSMYEGRFCRRDAPSDVLMKHHTASTHSTTLRNVQQQELSPPVPLQHGKGVFRDAGGSVYDGNWVEGEMTGEGSITFPSGATYEGGMYANRFWGAGTYTWSDGSRYEGQWENNKMHGTGIYIDAAGKRWAGKFYHGQGVGLLAEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W946</accession>
    <name>F9W946_TRYCI</name>
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            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
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                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
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    </comment>
    <dbReference type="EMBL" id="CAEQ01001259">
        <property type="protein sequence ID" value="CCD13736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="899" mass="100797" checksum="6AA950C163E83CF6" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W9W7</accession>
    <name>F9W9W7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1907</fullName>
        </submittedName>
    </protein>
    <gene>
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            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001360">
        <property type="protein sequence ID" value="CCD14022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47020"/>
    <dbReference type="OrthoDB" id="1708219at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="18780" checksum="0D277CA8D6249F9A" modified="2011-10-19" version="1">MTVRLPCVSHLGATAHSCGDMCKARSVVSILHTALEPPFYRYSILAAPFFHLVREGRGIGQQVAQEMVSRADCPVIPAQLELTKKGRTHPGLNRGPFGLQPNALPLSYESSANRSWSACGFFYGTLTEAPKPACCFTSGHHYTKTDSAKGPPVVCDATSTNVRAHLDHYCFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>F9WA03</accession>
    <name>F9WA03_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 1913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_47260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001368">
        <property type="protein sequence ID" value="CCD14058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_47260"/>
    <dbReference type="OMA" id="AGKDNTH"/>
    <dbReference type="OrthoDB" id="1267508at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031797">
        <property type="entry name" value="DUF5075"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16825">
        <property type="entry name" value="DUF5075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394796" evidence="3">
        <location>
            <begin position="29"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="783"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD14058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="857" mass="89352" checksum="96850A023A6E0E17" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAC3</accession>
    <name>F9WAC3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_48320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001413">
        <property type="protein sequence ID" value="CCD14184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_48320"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394804" evidence="5">
        <location>
            <begin position="21"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="85"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="399" mass="43774" checksum="8DB63A07D32C7CDE" modified="2011-10-19" version="1">MRMKVLLVVYFVVILNMVREYGSQADSQVLLSQNDNQEPFQLLCRIYNFAKNPPIKPVDTKEYKKMVDDIDALSAAANGREGVNTQTEEARSAQTQLIGITNEAHKLLDEIKKVNPEGEAERARNTFHQAISGEHGKEGDLSHVALRGVTGSRPVVCGSNNQGKGTSAGKNLIVDFFCICVNHEESYNRVDKVCGVSVGRGNVSGWGGTNLHSAATMWEEIKKGCGTFAQQGVTSTQDGHSLHHDFLAKIKEGGKVKVKNSETVHKTGMLGTAVSETGKNDFNCNGQGSTNRHSGSGSCVFYGDGKWEEDIEWLKKFKTGLETIVKLNNQTASWKSKLTTLQRQAQVLHGKVKANTQLEEEDTDDSPLAQHPNPDENENADSATQSQRHSHLAWALLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAM8</accession>
    <name>F9WAM8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1992</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_49320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001455">
        <property type="protein sequence ID" value="CCD14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_49320"/>
    <dbReference type="OrthoDB" id="1720615at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="19982" checksum="72ECA5D120B63F1F" modified="2011-10-19" version="1">MSWITLIRVHFLCRGGHHEEHFLPGLESNAGLQVFGIGGAADEGGKGEAGRCCVPLVSFPRTLCGTSSNNSNGCLTTQPCGARMLNTPRYGMVVRIYALNVIQAPFMILEKFTHGEKGKVLLDLPVERVNKIKKVNVIVVLYTPKKSLTELILHRQHGGSFQGNPLFSMRCMGPPKPKLVSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAX2</accession>
    <name>F9WAX2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2026</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001493">
        <property type="protein sequence ID" value="CCD14396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50130"/>
    <dbReference type="OrthoDB" id="841912at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="251" mass="26770" checksum="0FBB35D2E9F2BEB4" modified="2011-10-19" version="1">MPKVIKSSVKPMTSGLQELSGLNNEQTPANTKTTASTTAASAINEEEMQHWKNRCSLIEQQHRVSVQRLSELQAYIEQLRRDAQQAAVKVANSSSAPTPAAPAVSATVPLQTNFSSVHMSSIRDAWSNGNIATPTCQSDTLSFTQPPSSSCCADPSPIGVTSLPAQQAVGKQYGDTGPAPQHVIVPDALPNLGVAVTPTSGVDRATALQKLREDLDEECARFVSESERWKKFLQTQRCAIGSEAVGVSGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAY6</accession>
    <name>F9WAY6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2033</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001501">
        <property type="protein sequence ID" value="CCD14412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50280"/>
    <dbReference type="OMA" id="FRDCAVE"/>
    <dbReference type="OrthoDB" id="1346813at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20907" checksum="B77CB50F553203EB" modified="2011-10-19" version="1">MTEYADALTDAERYTIWCEKVRTLFSQTPINTNVEEENEDEHFFPYCFYVRMLGSVGKGAEAVGAWSQQSGGSEDSQFSSISQRYAHADEDAVASRLTTKLQAHARSLVKQQEKQRHVENLIHSAKLKLPFRDCAVEAKVAAINEDLHDMLLYVRRQNMLASELRRRLRQTQQLLAMRAPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WAZ6</accession>
    <name>F9WAZ6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2041</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001509">
        <property type="protein sequence ID" value="CCD14422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50380"/>
    <dbReference type="OrthoDB" id="1733610at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17138" checksum="9863B5DE411CA187" modified="2011-10-19" version="1">MRLQAGRGQPKKEAEYNALRAMRQESSAHLLVCPSLLPSRPKHDLECLKEGQVYHSEPLARSLAGLFKLKGFHDPTSYSPVEKSTRAVKGERSPDKLAVPSASALPLAALVFLRCVGENDLAEMHSHCKQAVLQLNWRKRGQDRRYDQNPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB11</accession>
    <name>F9WB11_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2047</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001516">
        <property type="protein sequence ID" value="CCD14438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50530"/>
    <dbReference type="OrthoDB" id="1688864at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="235" mass="28575" checksum="924AB109AFF468CB" modified="2011-10-19" version="1">MKIRDKQIPHNHFWNRKNFRRKSQKKIFFYKIFFENLQKLEKVFDTIFCKILKNHYARQIGPKTTNTCQIRVFRIFAFLTFLTIFKKTGFWPFWPKKGNLGKIAKCPFSLGIGSFLKRISGFSGKIRDKQIPHNHFWNRKNFRRKSQKKIFFYKFFFENLQKLEKVFDTIFCKILKNHYARQIGPKTTNTCQIRVFRIFAFLTFLTIFKKTGFWPFWPKKVNFGKIAKCPFSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB47</accession>
    <name>F9WB47_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2060</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_50880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001530">
        <property type="protein sequence ID" value="CCD14478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_50880"/>
    <dbReference type="OMA" id="ISDRERH"/>
    <dbReference type="OrthoDB" id="658419at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="386" mass="42413" checksum="451F5F36C3D973C6" modified="2011-10-19" version="1">MIQFNEVFMRTTLLLRVKRENVVDEQLRSHYDAVRHIVLSAFPSADVVFINPAFGNAMLDAGDDNGFMTQLRQMAYGSNRASALPVRRGPFSGCCSPREVAAWRSLYTKSPPQRPLREDAADPCWTPHAVVYVGGFESPDLHRVAAPKLFAEIPLLISDRERHITAGGRTFEGAPYKIPKFATKTLHKETLLQGKGCAVHEPDLLELAVPHAVGQTERRTRTLLSFAGLEATVEALHRIEEPAKRGALRPAFGYSAAALRCALPAAVVKAARLLRQWNSLWAPVPLSAAFWLSAVGHYVGSDAASRSVNSGTTGEENIDLLTKELALSTASLVNEKPESCCVNYFLPVEELNQERGVKELLSIGPRLPVGRMHEVFVNSFMESGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WB52</accession>
    <name>F9WB52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_05430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001532">
        <property type="protein sequence ID" value="CCD14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="113" mass="13199" checksum="A73DEEC88A0F01D8" modified="2011-10-19" version="1">MCRVTLMGQFKLFTCWAIFGPTRICNFHIDFLFSRVQNVLQMKVAPFCFSHFLWIISLIVIIILFRSPSPPYEHKHIPGTSPYCGQWDCVVTVLRIKYGPIDTKTRATQEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBH2</accession>
    <name>F9WBH2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2108</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_52090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001583">
        <property type="protein sequence ID" value="CCD14605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52090"/>
    <dbReference type="OMA" id="REFRRYM"/>
    <dbReference type="OrthoDB" id="1676180at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD14605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="313" mass="36172" checksum="93BF74D59290F4B8" modified="2011-10-19" version="1">MVGPLPRYVLWSEAMYAHRLRGVKNALELLPSDDFEYYMGMLDNPHKWYEDGTTHKLVKLVRCEANDEFECRNRVTSIYVREEIYRKMLVASIKASKLREILSGALEKCADLFEIAGLRAFLDKTTVDTLVRHLKYLPRKKERKRQSVLSQRHANGRVPTTLFEFASDGPKRELETGRLYKPLIPNFPLVDGFFVVEGKGPKTIVLLQITKAKEHHTKKTTVREFRRYMGKVFKSWKRIEGSCSWEIIYIQHANSTAIKKRQQCASSRDAANDTDLALWDRIHQYQVTLNTNIAAEPIKRGTGLLKVQAASDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBP7</accession>
    <name>F9WBP7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2129</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_52760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001607">
        <property type="protein sequence ID" value="CCD14680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_52760"/>
    <dbReference type="OrthoDB" id="1762239at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18153" checksum="B9211F4EE845F79C" modified="2011-10-19" version="1">MLPLLARSHLRKKWGPSAERYAEWLVMPNGEVAPSFRPELEAIRERRERSAESHGRQPPHHYAIPPQLPPPQQQPQSPTHAIDVRPILRKHHTKQGHGQASQPRREASPKAVAGEVSLRGCTGENEMQKVSSDKKIPDSPSSPQTPQLLSPLRGGGAGRHREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>F9WBW8</accession>
    <name>F9WBW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 2155</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_53430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001636">
        <property type="protein sequence ID" value="CCD14755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53430"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="853728at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD14755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="368" mass="41001" checksum="5F61996F8EDEBDAB" modified="2011-10-19" version="1">MSFLAKNLIIQRALNPPPLPSLEGVPFGTIFTPHMLVVDTETNESWGKPRIVPFENLSLPPQTACLHYAIQCFEGMKAYRDKEDNVRLFRPELNCQRLLNSTRRLCLPDFDPDELLHLIQRFVDLERDYVPRGRGYSLYLRPTVIGTSTTLSASASTAAKLFVIASPVGPYYGPVMKPVRLYVEERRHRAWPGGIGNVKLGANYAGPMLVQMEAGAKGFHQVLWLGAAEDVQEVGAMNFLCLWRPSADSKEIELITAPLDGTILPGVTRNSILSLVSEWGGIRVSERSFTIHELVAALRERRVLECFGCGTAAIVSPVEALSYEGELLEVPCPEPENSLTHRVLKTLTDIQYGDVKHEWSRVVEVSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC14</accession>
    <name>F9WC14_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2171</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_53870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001653">
        <property type="protein sequence ID" value="CCD14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_53870"/>
    <dbReference type="OMA" id="PETHDAM"/>
    <dbReference type="OrthoDB" id="1668132at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="448" mass="48460" checksum="3C092B19AC366EF6" modified="2011-10-19" version="1">MNVLEDKMTDNLAAEPEILQDGYNGAVPCDEPQLTPRPTTDDTREKSLSVLEQNDIPTDSPGKVLEDMQLADECNPAITTECEREDEPDNSLGVSDQLEEEEEEGSTVDDGDAVPDSAVNEDQPQARKVPVKPSQKDGVRRRHRRVREADYKAVTSSVINCAWGYTFSDTTGHVERSLLPPELLESREARRSHLNTPQALRLRVAQAARQYALAATGPESVEETSAAPRLTVSLLFQGPPPESGSSQASVKTHASPSCNRDRIPAEDEIRSDEENGEGSDRGVSMGDHGGHGTTLFHEPAADDDIKEGSVPHDDEPACMPSQGLPDGGEAGNDVVGCSSGPEACASDTPSVKPCDPSTMALLCRRNQKQAYDDFVRPYRTSLGGAQVSPEATGAPEAPDATGERRDLEMLTPRVYPVASRVLEKESDVWEKVADILGELHDKMVSPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WC81</accession>
    <name>F9WC81_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2195</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_54470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001680">
        <property type="protein sequence ID" value="CCD14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OMA" id="RIRMWAN"/>
    <dbReference type="OrthoDB" id="1115202at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="897" mass="100694" checksum="6CD71FCADB0CE5E0" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCD8</accession>
    <name>F9WCD8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 2217</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_55000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001704">
        <property type="protein sequence ID" value="CCD14931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55000"/>
    <dbReference type="OrthoDB" id="1705862at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10676">
        <property type="entry name" value="PTHR10676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD14931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="207" mass="22933" checksum="87E2BF5B761D42B5" modified="2011-10-19" version="1" fragment="single">MCAIPQTPWACHQKKKVSVSGDGHAKFFFRFTPLAMLQHFLRPDPLAPTGKEASKIRRGQHTTESAHLSGANADGSQASMETDAGSEKPDANLSLDLVSISATYKETAVLFPDAHQAAFEPKVQVPFEHKRGRIPREIEIERCRRLYESKNVSHLVDVAGLSLKLLAHKSSQELPLQVFDDTSYDSRIPAEWMEIAGRNENPAGRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCJ0</accession>
    <name>F9WCJ0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TCIL3000_0_55510</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">IL3000</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001729">
        <property type="protein sequence ID" value="CCD14984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_55510"/>
    <dbReference type="OrthoDB" id="1673327at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394674" evidence="10">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="11">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CCD14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="395" mass="42878" checksum="C3E1C9FCBC3C812A" modified="2011-10-19" version="1">MELRSKWWWIIALLMLLAEEALGTGPKAIPTKAGAAICTLSKTLKDVTPWATQQVKDGVAKITHLEMKLLEWQTKFMQSNSKGIGSQACKITGLLFRQVRKEIEKARREVEKLEKEASRAAAFAANSAGRLDEFITVFANAKGDSNHYCLGSDKAATAGELKDCFSGTDFREQSLVDIGELAGGKEPDLAADIEGVKHQSVKDSFDGGSSSGCNFTKGTPDGILKSTDLENSLWWGGGILTIGKAFDGVFNRENFSAGEIANNTKEGKHALWTADPASQIVHLKNASDAFKAFKAVQEKIKEKVESIEKKIQECMGSPEPGANNTDQNATEPTTTAEQTPTSTTCFSNVAKIAADLKEKRALLARYQKVKGWIPPSSAFNAKNPFNHFGILLALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WCZ3</accession>
    <name>F9WCZ3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2297</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_57010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001794">
        <property type="protein sequence ID" value="CCD15141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57010"/>
    <dbReference type="OrthoDB" id="1729071at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18191" checksum="D67FB12A8D2930F9" modified="2011-10-19" version="1">MSTFIVGRVTSGLVHGNGMIRALVGDSAKDVTKTANTTPTRATGIANNWCTISAAGADYVTGGSTCVGPCFTRPHGCICVCKKKEWFHSPPQEPPSCQCSYSLLPTLQEVFHSPVENATEEERGADSGKWKGAFKPVARSWQTVLVEWNAFRHASAGHELPADDNVLSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WD85</accession>
    <name>F9WD85_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_57780</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001836">
        <property type="protein sequence ID" value="CCD15236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_57780"/>
    <dbReference type="OrthoDB" id="1676861at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389002" evidence="5">
        <location>
            <begin position="17"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="49"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD15236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37780" checksum="B3EC6DBFC7E7ABC5" modified="2011-10-19" version="1">MKIWMVMMVFFGVVASADEKDHNGAQHQALCDLMKAAVGKWGSSGEGLSEPLKKALHQTIFGNESGGSLETLRNGLPKDYEEVLKQSDSRNFACGQHYNDPTELGRVHQVLRSGQSAPHDLVCLCTVGDGGWPLNISDSEKLCGLDKSSLGGGSEGWGDESHETKVGKKQITATWNKVTTPCLKEGQGGDLKKALHNLINKLVNTSVVWYPSRFQLGEGEPSDDFACTGSPKRGVCVEYYNSTTTLYPLPWWSELEKAIQKDKEIQEQKKRDEEEKRKQQDEAEQQNSQKPETLKSGPQTNNQTEQPKKDNLTDKLRRYNLTSGTPTSLPSSWLLSAILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDS7</accession>
    <name>F9WDS7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2400</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_59530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001908">
        <property type="protein sequence ID" value="CCD15431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59530"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_6" evidence="1">
        <location>
            <begin position="124"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="346" mass="38174" checksum="229ADC378DC58090" modified="2011-10-19" version="1" fragment="single">MRMHLWSSRSQVPSNIRVTESVGKVRSTAYGSQRRHNFLVTSLLLLLLLTISPGVEGELDINVLSLIHNPEFPVGGARAFDNGFNASLSARNSQADIKVRVAFLSSTSSDMPVDELLEEIIEKSEDKLLLVLGPLGDDNIQGIKAVLKEHHIIAFSPIATSNFAFGWNPYLYYISVAPDAELMALVRYAFGGLGLRRLGAMYVNDTAFGQNSYNFITKLTTEMGHDIAGVFVVATGASDAEKDTEWEAEWNKFVESRPQAVVLLGPRTDDTRKFIVNVAKDNRTSRSYILAPSGIQSFVLELSQEVMSVAGSEFAPGQVFFSGTTPLASDNEFKMIRRFITEMGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9WDX0</accession>
    <name>F9WDX0_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA polymerase kappa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_59930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001924">
        <property type="protein sequence ID" value="CCD15475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_59930"/>
    <dbReference type="OMA" id="RTQFKGR"/>
    <dbReference type="OrthoDB" id="878533at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="158"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD15475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="610" mass="68849" checksum="7659199E428A9B41" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE39</accession>
    <name>F9WE39_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 2433</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_60370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001946">
        <property type="protein sequence ID" value="CCD15545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60370"/>
    <dbReference type="OrthoDB" id="1666696at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="439" mass="48295" checksum="C2DE136807BF95CA" modified="2011-10-19" version="1" fragment="single">MSLLQFLSVSDHSVILPLQFLSVSDHSVILPLQFLSISDHSVMSLLQFLSVSNHSVMSLLQFLSVSDHSVILPLQFLSVSDHSVILPLQFLSVSDHSVMSLLQFLSVSDHSVILPLQFLSVSDHSVMSLLQFLSVSDHSVISLLQFLSVSDHSVILLLQFLSVSDHSVILPLQFLSVSDHSVMSLLQFLSVSDHSVMSLLQFLSVSDHSVMSLLQFLSVSDHSVILPLQFLSVSDHSVISLLQFLSVSDHSVMSLLQFLSVSDHSVMSLLQFLSVSDHSVMSLLQFLSVSDHSVMSLLQFLSVSDHSVMSLLQFLSVSDHSVISPLQFLSVSDHSVISPLQFLSVSDHSVISPLQFLSVSDHSVMSLLQFLSVSDHSVMSLLQFLSVSNHSVILPLQFLSVSDHSVILPLQFLSVSDHSVILPLQFLSISDHSVMSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WE69</accession>
    <name>F9WE69_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 2443</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_60610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001957">
        <property type="protein sequence ID" value="CCD15575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_60610"/>
    <dbReference type="OrthoDB" id="1654626at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="825"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1003" mass="116929" checksum="BE464873FA367C70" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEC8</accession>
    <name>F9WEC8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 248</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_06540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001991">
        <property type="protein sequence ID" value="CCD15635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1654475at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18587" checksum="BDEBDA998B7341FE" modified="2011-10-19" version="1" fragment="single">MAERKVKQAGRKAATDAAGRSLASSKAAVARVNGTWTLDSLVKNVLMERCSGPGDMSLHDFLMKHFKKTFGVENVSLAVFMGDPSYYVADESVLGKITSSSPYMELMEYKTMRKEVNRLHNMGIYSLRQWADAADNVRNISVQVREKLNAALGSAGHTGEPMRDVDALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEE9</accession>
    <name>F9WEE9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 257</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_06740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002001">
        <property type="protein sequence ID" value="CCD15656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_06740"/>
    <dbReference type="OMA" id="FASRTWS"/>
    <dbReference type="OrthoDB" id="1363674at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="447" mass="51118" checksum="A2B4CAED0F19A0F9" modified="2011-10-19" version="1">MAAEENKPSQRIRVHDTALYTQLMNAADWSHIIESEGREQRNSLAKREAEIALLRQQEREKANEVKHRLELLMLTRSRRKREEKQERKHVKEFRERMRTLRQHHNELASKCAAVCRSDVVRAQRALQRLGWQREELVLRPIQEAINEAISDDASSRFRAALRLKMIESYVEECNRANVSASRGVFRDVFDPVLYNPFLQREMCTIRYPRPPQPRTVVDIHRSEAEEIEKKYEQLALDYRKLQAESLTGALSKPSLAAGPLHTLTQRATPSDEVVDFPVGQLSYFPRRRATSSSNPPELRSLKDPRGSTESGDTEMEPNRMRILPPLTRGPERSAAGACAVLGSEPSGGEVMPFLGARETENDRLVQWMRQRRRSVQTRFGDLPVTAWEHFPQTSLGWNTAPDGSTKAFSKRRVDFANYRQYSQVELAYYSGPGPCPAASCEGCCADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEK1</accession>
    <name>F9WEK1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 280</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_07240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002026">
        <property type="protein sequence ID" value="CCD15711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_07240"/>
    <dbReference type="OrthoDB" id="1684086at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="291" mass="31997" checksum="19C52FFF4354C2A2" modified="2011-10-19" version="1">MYVGLFRAVSCLNDGSFFELLAFGVQEARQRNVQRVTPMRATCLLTITGNIPLSTYTTIATVACADVPGFMPHTVSPQVRCKPSVFLLVSSDHSIPPARHTSTTYSSHPAICAHTQRASKSFGNAVLFTTVPPTVSWSLCHIPRGENDGTSKHKRLLTMTGGCLNCTSCAAWDKERLRPSEPLPLKSKTAAPFPLDVQPFSRLSTHCDMLLHLIHTNTTLLPSAVVRRSLPHSPFSVQRKQLPCYMGLAEHRNHLAFAVPGNPPVPVRRVTVHAVSHQNKRAIRHNSLNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEW0</accession>
    <name>F9WEW0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_08270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002068">
        <property type="protein sequence ID" value="CCD15826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="13733" checksum="BC91D841364A95B4" modified="2011-10-19" version="1">MRYANAHSVKVIDGVYDSVFKAGWCYVVRSDTDDKKWLGMGVLRVGEGEQPHLWSEAQADVPYDPEEPWEGDVVPGAEGKLVMAVLSSQKGWPYGFFQGGDVRKEKAKSRTGYNAACDAYIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEW8</accession>
    <name>F9WEW8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 322</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_08350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002072">
        <property type="protein sequence ID" value="CCD15834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_08350"/>
    <dbReference type="OrthoDB" id="1763063at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390237" evidence="1">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17326" checksum="FCC1941410F8ED29" modified="2011-10-19" version="1">MAIVSNLLLFLSSSSSAPFVHSTSLIADLKKKKISFTLFLLFTFPPCNYYSCSCCSRVMLLLIDQCTISSTFSGHHISFSLLIYPPHTPCHVRKRKKKRKNKKTKLTQKEMFVTIQNHFTKPSRVCHYNDMYCYDLCYSIPPPHPLLQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WEX4</accession>
    <name>F9WEX4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_00940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002073">
        <property type="protein sequence ID" value="CCD15840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_00940"/>
    <dbReference type="OrthoDB" id="1657124at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="455"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD15840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="813" mass="94799" checksum="8E662BC4177D8F89" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF54</accession>
    <name>F9WF54_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_09140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002105">
        <property type="protein sequence ID" value="CCD15922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD15922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15259" checksum="8201E73FCEAFB96D" modified="2011-10-19" version="1">MFLLLRSFFNLMQALTIINSLHPQNHTCSLNALLSSHALHRNAAVLPHRIRGGSGVLGINIHYPSHPSNKNKTKKRYALTSPLTSRGKKRKAKTFIRFHISPKCVIFTFCYCRCCFLFFSLSAWGDRVVRPDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WF97</accession>
    <name>F9WF97_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002118">
        <property type="protein sequence ID" value="CCD15965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01080"/>
    <dbReference type="OMA" id="TMSITQG"/>
    <dbReference type="OrthoDB" id="1007172at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032942">
        <property type="entry name" value="BPI/LBP/Plunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10504">
        <property type="entry name" value="PTHR10504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="SSF55394"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPI2" evidence="1">
        <location>
            <begin position="169"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD15965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37401" checksum="AEC01AD9F3E8387E" modified="2011-10-19" version="1">MVRNSNASVLLNLSIGTDHLLNVTVGRMAIMLKDLDVKPSIKNCPVIDVVVDAIIRIFKDIITRQLQEIIPTVLGPMVENKTREVLRGLPVNFTHAPNITNGKMELPVTILPEVPTGVGLPPEDASLYNRPHPHWDISILSSRSATNNVLRFLINRSLLWISKPVQPEYTTALIQPVFPKLYELCPNCTFSVTWNVTDAAWLEPLKDGGFVFNLRNSVVDVEMLASNGTRVDALRALLSTTSSVAQLLIRNGTLNIKIPSARLTLANATSPVGPINSTKLSADLQWILDDFLLPVVNHNQQGFSFSAIPKGLLFNATADAVAIGLDAASLYSLLSARLKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL0</accession>
    <name>F9WFL0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 397</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_10490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>IL3000</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="3">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002156">
        <property type="protein sequence ID" value="CCD16086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10490"/>
    <dbReference type="OMA" id="VGSCAYL"/>
    <dbReference type="OrthoDB" id="720211at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="81"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="955" mass="105944" checksum="3B3032086D4A8FEB" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFL9</accession>
    <name>F9WFL9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 402</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_10580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002161">
        <property type="protein sequence ID" value="CCD16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_10580"/>
    <dbReference type="OMA" id="RSEYACE"/>
    <dbReference type="OrthoDB" id="1725894at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="332" mass="33472" checksum="D910CD91259229EB" modified="2011-10-19" version="1">MEVADNADPEVTAADAMEVADNADPEVTAANAVEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAMEVADNADPEVTAADAVEVADNADPEETAADAVEVADNADPEETAADAMEVADNADPEVTAANAVDAEGNMPVKSVMSVLQSVGDYAFVGSFFDKKECLGHAETAADAMEVADNADPEVTAADAVEVADNADPEETAADAMEVADNADPEVTAADAVEVADNADPEVTAADAVEVADNADPEVTAADADEVADNADADDNCRRCGGCRSEYACEVCHECSAHCGSVGICSLCNGCSRQCGSCGNCSRCSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFS7</accession>
    <name>F9WFS7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_11060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002184">
        <property type="protein sequence ID" value="CCD16155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14428" checksum="774302B02E3BE848" modified="2011-10-19" version="1">MVWLASSYSRSLYCCAWMAVLIKFSALPRSYRLFVLFSSKSCRISSTERSTCFLFISTSWYPPFVIFQISVTPLPSTFSSRFCMSHSFPRVSGLSLHKRSPVCSPFACLPNNTNATTTTTAKTQPRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFU7</accession>
    <name>F9WFU7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 424</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_11260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002186">
        <property type="protein sequence ID" value="CCD16177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11260"/>
    <dbReference type="OMA" id="RWKRPKY"/>
    <dbReference type="OrthoDB" id="252727at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="SSF49758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="3">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="593" mass="65591" checksum="F6D967104F88B6FA" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>F9WFY2</accession>
    <name>F9WFY2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 437</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_11600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002200">
        <property type="protein sequence ID" value="CCD16212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11600"/>
    <dbReference type="OrthoDB" id="903175at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="712" mass="79031" checksum="A4D582E43E1F807E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG01</accession>
    <name>F9WG01_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 446</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_11790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002210">
        <property type="protein sequence ID" value="CCD16231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_11790"/>
    <dbReference type="OMA" id="NTAHVIN"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394745" evidence="1">
        <location>
            <begin position="25"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="122"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD16231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46562" checksum="101AECEAE7B3522F" modified="2011-10-19" version="1" fragment="single">MCVAHRPPVMQMLLVLSLLTPGRGLTNNSSTTGNACGNMTVHVCVNTTGNVCGNTTVNVCSNITVKVYNLIHNPNMKQEYARALVAGFNASVNSTMTAERLPGGVKLEVVYVSPGSNGAMTPDVVLEHLEKKVNSSHNYSTLPVMLGPVGDVTAEHLLPVLRQRNIVAFAPFTGSSKIRVWHKNLYFITASPTAELLALLRYAVTQLRLERLGFMYLQGVSFGDEEYRLTVNALSNIGRGLCGLFTVKSSLTARADKGEFEAAWKKFAETRPQGVIVFGSPLHDTKEFLKRMQTEEGMKKVHLLLPSVLQLITEDTYKETVGVTTRRGKSPIYVSGTNPLAKDTNYKAIKRFREDMQNYLKKEPAGKHHSIQQHHYDHNDIDGEFMVYGWLAGEVLKEALGNPVWLKDRKTFMDSLYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WG96</accession>
    <name>F9WG96_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 481</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002249">
        <property type="protein sequence ID" value="CCD16330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12690"/>
    <dbReference type="OrthoDB" id="1713184at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19773" checksum="D6D3DD8D55D42E10" modified="2011-10-19" version="1">MVMHVSYLPWEREAERSRASVLSRYRLPASIYSFEAADQQCRLEEKWLYKHGWENFPIACGFFLVDAVSEGVSLSEGAEASTRAMVLLKVTKTRYHHTKTSKVKRFLNRMAETFTNWDEMESRLRCEIIYVLHADSATIKTRQRCDSGGMACDAGIEEFCDGIGQLLVKLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGB8</accession>
    <name>F9WGB8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 486</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_12900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002255">
        <property type="protein sequence ID" value="CCD16352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_12900"/>
    <dbReference type="OMA" id="YIFSASR"/>
    <dbReference type="OrthoDB" id="1709467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="21897" checksum="D345A1397033E616" modified="2011-10-19" version="1" fragment="single">MAVYIFSASRTSVTGNSVRRSLCFRAVELLATSLLLFLSTGRVDANTTVRVYSLMYHENVPDNFVEAVNAGFNASLASRQWAVAHNMRVKVTAPRTTSTPPIVALENAIKENEGSFFLLLGPIGDFTTNLSFVPTLKSQYLVAFAPLTASTASRGWNPNLYFLRVSATAELLALIRYAIGQLRTLRLGFMYLQDVSFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGF3</accession>
    <name>F9WGF3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transferrin receptor-like, ESAG6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_13130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002266">
        <property type="protein sequence ID" value="CCD16389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_13130"/>
    <dbReference type="OrthoDB" id="1669755at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394758" evidence="8">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="98"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD16389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="380" mass="41722" checksum="D120C493BB938E07" modified="2011-10-19" version="1">MLQAMKALGIIFMMSILCSSAAWEYPYPRKAVPTEAGESICGINKKLKDVSSWTQQKISALRKTRDEYESKILDWKLHFHESPGCGGNESVLEEIHTALEAVNGEIKKLPAKAILAAALAAKSAGRLDEFITVFANAKGGHNYCMGTGGKPAERRDLSECFSAGVDFEVGEPNMATIPQHPSERGEPNLEAVIHRVNHSIMSAYFRRRYGEDAHADCNLIKGKDSGILIGQISEKLWWGGGILTIGSGFDGNISKLKGAKDKDSGEKTFWTASPHTIPHLKKTLAAFQAFKDAAALISQKFSEIENIEKQIEPCLSNETMEERPTQSCFQNAIKLNAELQAVNAMLARYHKEKGPLPSGSALILQAQSVMHFLYLIAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGI0</accession>
    <name>F9WGI0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_01600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002274">
        <property type="protein sequence ID" value="CCD16416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01600"/>
    <dbReference type="OMA" id="METPYPK"/>
    <dbReference type="OrthoDB" id="812358at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="169"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="291" mass="30837" checksum="C820ED702A905ECA" modified="2011-10-19" version="1">MTAVKVALLGLGVMGYPMAGHLKTKGGHDVTVYNRTAAKAAKWAEQFGGKHAATPAEAARDADFIFCCVGNDDDLREVTTGTNGAFSTMKKDAIFIDNTTASAEVARELDAEARKRGFHFVDAPVSGGQAGAENGILTVMVGAPEAVFDKAKPIIDAYARSVGLMGPVGSGQLAKMVNQICIAGLVQGLAEGIHFGKKAGLDIEKLIGVISKGAAGSWQMENRHGTMNDGKYEFGFAVDWMRKDLGICLEEANRNGALLPVTALVDQFYKEVQKIGGGRWDTSSLLARLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGS5</accession>
    <name>F9WGS5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 539</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_14300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002314">
        <property type="protein sequence ID" value="CCD16512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_14300"/>
    <dbReference type="OMA" id="GECWFNV"/>
    <dbReference type="OrthoDB" id="699167at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD16512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="365" mass="40776" checksum="77953104BA1D2EB0" modified="2011-10-19" version="1">MKNGPPIFTSHFSGCGGVHAVEYFCADQFEAAGVFPTGREISLAAGGVLIDKEKASGFPVLSSLFEEPSTIARHQRMSEEVARVSAPILFNLSNQTVFPCPDGTALDIIRRFTLLKGYTKPYFVRHTRDFAEVCPLKPKEQGLVLNSSRAYGMGLDSRLGECVFNVEQFEEPQCVEELIVKTPTNFPNQSPFRGVRCALACARAQRAKSGFSHLWIPATFLSYLDGKWPLLPGATRVEWGMYLSTLMPALYNVSDVEVPPNALEWWPTYVPHDALHRPLTGAARGVVSLRAWERGYKSPMWMTHVMMTRFGAKLKPVGRKRSYLRGDPFGESRGVVIGNRKYFNIEEVENVDQFLTNLRNTGTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9WGT3</accession>
    <name>F9WGT3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_01650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002319">
        <property type="protein sequence ID" value="CCD16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_01650"/>
    <dbReference type="OrthoDB" id="1666320at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23602" checksum="F1808D41BC3C7ED3" modified="2011-10-19" version="1" fragment="single">MDQRSTNTRPASAQMYKTPPEIRAGARPRPVSSQSHCHPASRINAAINWNLGYKPPEPLRLPGGCVYPQWTRGIVLGRNAANQTTQQLPQKSSSTPWRFGRYRGGWTIEPATASPTRSSAAILTISTYSSLLSDAIGPKSKMQPQKKSGPLQQYHVVDLIRSLRRGKAVKDNNESERKEEKMTETIPTRTTEEKESIHEDKQKTRPNRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH05</accession>
    <name>F9WH05_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_15040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002357">
        <property type="protein sequence ID" value="CCD16594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15040"/>
    <dbReference type="OrthoDB" id="1675549at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003395043" evidence="5">
        <location>
            <begin position="19"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD16594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36764" checksum="E0367039522658AB" modified="2011-10-19" version="1">MMMMKIWMVMMVFFGVAASAVDKNHNGAQHQALCDLMRIAVGKWGDRGKGLSDTLSKALNRTIFGKEGGGDITELRKQLPNFYEEVLGGNAARSAPCVGRQSGQSAPYDMVCLCTKGHNGWPLSEPGIETLCGQPRTALETGDEGWSDEERNKGQKELNATWRNVVSPCLEGDIGNDLKEALETFKGKLVNKSDEFYPGMYQLGEGKPVRYSACTGYSPLGVCVMYYNGTEKMDHTPWWVDLENALPEEEKFQEEKKKREEEERRKKQDEQQNLELPQTAALRSAPPATNQTDQQHNGLNLTTHFHRLNMTSGTLITPPCIGFLTVAILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>F9WH52</accession>
    <name>F9WH52_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 596</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_15490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002377">
        <property type="protein sequence ID" value="CCD16641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_15490"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021057">
        <property type="entry name" value="Trypano_invariant_glycop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11727">
        <property type="entry name" value="ISG65-75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394773" evidence="3">
        <location>
            <begin position="22"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="575"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="71"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="400"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD16641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="640" mass="73623" checksum="181B2036DD9DECB9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHH7</accession>
    <name>F9WHH7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_16710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002438">
        <property type="protein sequence ID" value="CCD16770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16554" checksum="A8337431DE1FC551" modified="2011-10-19" version="1">MFFRVIFSFPSPGALQNCFCNNYFVFFRVIFSFPSPGALQNCFCNNYFMSFLVFHHPARCKTVFATIISCFSVSFLVFHHLARCKTVFATIISCFSVSFLVFHHLARCKTVFATIISCFSVSFLVFHHLARCKTVFATIISCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHI9</accession>
    <name>F9WHI9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WGS project CAEQ00000000 data, annotated contig 65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_01790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002442">
        <property type="protein sequence ID" value="CCD16782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1357557at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="456"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD16782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="648" mass="73078" checksum="7F4DC52BD27AB167" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WHY4</accession>
    <name>F9WHY4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WGS project CAEQ00000000 data, annotated contig 705</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TCIL3000_0_18110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">IL3000</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002498">
        <property type="protein sequence ID" value="CCD16929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18110"/>
    <dbReference type="OrthoDB" id="1318335at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CCD16929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="315" mass="37236" checksum="B4495FF13AC9C449" modified="2011-10-19" version="1">MRAPEMARREDEQRMQTDKQKEQTKAVGPVPPGFPCPHPLCKKTHAFHEEMNDHIRDDHEDKQKPGVDFMMFVCPFCLSHCETYKRMIEHMQHDHEDEEDNHPDSAGMKCRYCEERFRSYGDVVKHIEKDHSGEPALDDDMVVQSMQFKCYHCEKTCASYRGLGEHIGEVHWNKRPPQPYANDEGMWAPCLHPLCEQEFPSYEEVERHIQDDHLNWGKPGVDFMMFVCPFCLSHCETYKRMIEHMQHDHEDEEDNHPDSAGMKCRYCEERFRSYGDVVKHIEKDHSGEPALDDDMVVQSMQFKCYHCEKTCASYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI53</accession>
    <name>F9WI53_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 733</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_18670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002529">
        <property type="protein sequence ID" value="CCD16998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18670"/>
    <dbReference type="OMA" id="RNPLCVY"/>
    <dbReference type="OrthoDB" id="710473at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD16998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="432" mass="47335" checksum="A938CA03EBF55A62" modified="2011-10-19" version="1">MGKRKEKIPPPGTSKDPTTNFYSRKKWRTVLLANVLELQGKELVPRGMQIIGNALTKNRHVVRLELAHNHIGDVGAIALADLLRRNETIQHVNLAQNDITDVGGIALASAFIPNVSPNGQAGQWNRTLFTLVLSANELGDATLLALSKAAACHRDLMRVDLSFNKIGPLGTKCLMRAMQRNPNCGYDLMGNQIGDEGTEYLCEAMKRFAGKSTTGLNLFRNDVRYRGCKAVGHLIENNEFIHNLSLHSNTLGLRGVQELRHHLTRAPNCLRSLNLSNCMLGDSGAAEIAAIIESDMPTLERLSVADNDMTDAGGVTIVKALMNNTSLITVDCSNNTFGAKTVEATMLLVEKAKVLKQLDFTNSIESGDMRRTLAFASSDADSLTVDVGEMQEDTYESIVQRIGEHMQLILDAEMEKAKSRKGKRKQKNVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9WI91</accession>
    <name>F9WI91_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WGS project CAEQ00000000 data, annotated contig 750</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_18940</name>
        <name evidence="8" type="ORF">TCIL3000_0_18950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">IL3000</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">IL3000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002548">
        <property type="protein sequence ID" value="CCD17035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CAEQ01002548">
        <property type="protein sequence ID" value="CCD17036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_18950"/>
    <dbReference type="OMA" id="QTETIKW"/>
    <dbReference type="OrthoDB" id="1340833at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="5">
        <location>
            <begin position="14"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="6">
        <location>
            <begin position="71"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CCD17036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="194" mass="22356" checksum="DE3B01AB1DBFC494" modified="2011-10-19" version="1">MTEAKVSAEKKAANPMREIVVKKLCLNICVGESGDRLTRASKVLEQLCEQTPVLSRARLTVRTFGIRRNEKIAVHCTVRGKKAEELLEKGLKVKEFELKSYNFSDTGSFGFGISEHIDLGIKYDPSTGIYGMDFYVVLGRRGERVAHRKRRASRVGFSHRVRKEEAMKWFEKVHDGIIFQAKKKKRAMVRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WIU9</accession>
    <name>F9WIU9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 837</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_20810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002644">
        <property type="protein sequence ID" value="CCD17247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_20810"/>
    <dbReference type="OrthoDB" id="1233632at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18709" checksum="6432C8DF4E83F489" modified="2011-10-19" version="1">MKVCEAQYAEAADKVFPPQHAIYSKLEKVRHTCDTIEVSVRQHEATVLQLAERACLNTAAPGVLKAETPEEEGKVHTIRRVQRFNGYDYQAWTDGPVALDVSSGSGALMYPPNGKKEKITLDGRNLNSVFMKECVVMEEVLHRLLRSIEVNELRKMREWLPPRTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJ41</accession>
    <name>F9WJ41_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_21690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002680">
        <property type="protein sequence ID" value="CCD17343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="143" mass="15295" checksum="AF99BEBE79B606F9" modified="2011-10-19" version="1">MVGPEIAGLDSRLSTISVACVWAWRVTTYCDATSRGLGGGRVMVLIGMLKSSTIVRSARTGTILVVRVLYAVIVGSAKVININVTARSNVIPTSGSSFKNAVITVRIAISRDIPTPLFVKNLTFIHAERPVLEKTATQVQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJD0</accession>
    <name>F9WJD0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 898</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_22530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002712">
        <property type="protein sequence ID" value="CCD17434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22530"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20162" checksum="32AB005DF31B14E0" modified="2011-10-19" version="1">MSNSPSSPSPEGMAQDNTPWSMEKDVVEVLLKNIGDPEKINLYRFLQPAYPFIHSYVSRFSIRDFARNPWRCVGEADGREKVWQQFPRLLWQFRVLALKLVYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPPQPRGFLEAPYPIGYTGPIPMPHPPEPGTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJE8</accession>
    <name>F9WJE8_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_22710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002717">
        <property type="protein sequence ID" value="CCD17452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22710"/>
    <dbReference type="OrthoDB" id="1426427at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003394824" evidence="5">
        <location>
            <begin position="24"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="57"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD17452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="349" mass="38226" checksum="D79D3D98C2CCCCA1" modified="2011-10-19" version="1">MKGREMKILMVLVVMGIMSRCVAYSNVHNHNGKEHDALCSVLGAVVTLYRSARGGPTLQKALRRALFGNENGDGDLNTLLADLPSTHHNPGHRERSCGDCRYGGGEDYPGWSIPHDLLCLCTVGKNGYPFTNDGQNSKMFCGQSAQNLGCGNGNGCHNGNEQHGWSESSRNGQAKEYLSATWKTVVTTCLRLGFNLDVEKALQILKEKLKVEEHKSAAWEGSHYSCGGDFSGGGICVNYGGSCRYRDQRFPQWWDALQDALPTANFDLISTHQTASTSPLLNSTYDDEGEDGDELGPNGDSHNGTRHGPSSTRRRNKRSNHAVSHLFKEDGTLLSPPFLWSLGAFVSWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH1</accession>
    <name>F9WJH1_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 911</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_22940</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002726">
        <property type="protein sequence ID" value="CCD17476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22940"/>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_BAC1H7_006"/>
    <dbReference type="OrthoDB" id="1726192at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="17"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD17476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18684" checksum="0EBA5B3C18AC4DCB" modified="2011-10-19" version="1">MKLLEWQSKFIQSKSKASGSEACKITGLLFRQVRKEIDKARKEVEKLEREASRAAVFAANSAGRLDEFITVFANARNENSRGFYLGNDKLATSEESKDCFGGKDISIECLVDTFERASEQKPNLDTKIEGIKHQSLKDSFRGGSSAGCNLIKENAGGILVNTELGKSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH5</accession>
    <name>F9WJH5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 913</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_22980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002728">
        <property type="protein sequence ID" value="CCD17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22980"/>
    <dbReference type="OMA" id="QCASETN"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390433" evidence="1">
        <location>
            <begin position="25"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="2">
        <location>
            <begin position="129"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="779" mass="85723" checksum="F233FE7C6A172AF8" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJH6</accession>
    <name>F9WJH6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_22990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002728">
        <property type="protein sequence ID" value="CCD17481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_22990"/>
    <dbReference type="OMA" id="GIHTELC"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003390491" description="ATP pyrophosphate-lyase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="911"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD17481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1147" mass="126096" checksum="9647CC1A90261631" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJQ5</accession>
    <name>F9WJQ5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 936</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_23740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002754">
        <property type="protein sequence ID" value="CCD17563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_23740"/>
    <dbReference type="OMA" id="SEDIPYF"/>
    <dbReference type="OrthoDB" id="908664at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="323" mass="36909" checksum="B27521B5C1679296" modified="2011-10-19" version="1">MACHALYSRGKSVLASVCGFACGWYVYRFAEEQQLIGDTYLRTIRVGFLKTQLLLQEHILPTKFTEKYGHEAETLKAMIKYWNSKNDSEERWSFEQLFRECQVPEQIAWLEEHVSEDIPYFYIADLVGGWCRVHKKYYASNGGWKAVDADEPQLLVGNDERFVSSVLCKGIVEKAKTDVLPYDIAVRALCILASSHEANAQVLSNTINPQFIVEKYRNYVENLQTHSQTNKEAVAIAEVSAATLELLNAINKVLQKQRRIKIWLNSTERQHPVAAQLNATQWCTVFNDTFLDLAKETSKEAHQFLEVTSHFFKCPHSTAGSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJW0</accession>
    <name>F9WJW0_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 958</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_24240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002779">
        <property type="protein sequence ID" value="CCD17618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="257306at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD17618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="424" mass="46043" checksum="0747CD2283EBE34A" modified="2011-10-19" version="1" fragment="single">MVLVVEERDLEIAFGVSLATLVLVCLVQHIAVLVSRLPARLVNFQWYYVSLSCAPVCFVVSSTLSSITWFLVAAGAGLAVASGVRTRRRMVTAFLIGFLLTGQCLEQLSHVVNVVVPPKGETWVSQYRGQTALWPEEAGSGPRSLLVLYENVVLTRMPCENTGTAGASTQSGLLAGLGDRHLLVSFGDNTRVGAMEGCRSGGCDQRVPWHVVTLLGENNLLEDVTVRCRVASGKESSAGRGGEHWRCLTVNPSTMFRNVSLEFYSDDGLDFVAKIHLAENCADASLQLQRLRKAGVEGEKNVLTCIENAGSHRFSQYVQDPALVPSVLRVLVPYFFRCVWYMPMTLRNIPSVVTSVADYVIFPLGGMIASASFAVIKAIVLMCWDLLPDFNRILNDAGMFVLGSYCRAVGATHLSLCSAPGDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9WJW2</accession>
    <name>F9WJW2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_24260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01002780">
        <property type="protein sequence ID" value="CCD17620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD17620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15815" checksum="7502B8B21F10CDE7" modified="2011-10-19" version="1">MALSCIEALATRRKGRASGAVKLPADGVTKNNQTAASFGHAAVGRVSVCSVGHPKGRNPINTAFVFLRHQKPKLGRALEKRQVHVEHQKARRLKQMGEKGCQTVAPLSEAALRDIKRKAVGYLLQYFTRTQSFIGIRRSNIKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3L6</accession>
    <name>F9W3L6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1073</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_26900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000433">
        <property type="protein sequence ID" value="CCD11737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_26900"/>
    <dbReference type="OMA" id="AMYFIKE"/>
    <dbReference type="OrthoDB" id="1067605at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043533">
        <property type="entry name" value="CNBD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23011">
        <property type="entry name" value="PTHR23011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD11737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="539" mass="61019" checksum="7E562FE3357A39A9" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Q8</accession>
    <name>F9W3Q8_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_27260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000455">
        <property type="protein sequence ID" value="CCD11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_27260"/>
    <dbReference type="OMA" id="RYQGEND"/>
    <dbReference type="OrthoDB" id="962471at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="PTHR11588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="47"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36761" checksum="D31F4889EC9A610D" modified="2011-10-19" version="1" fragment="single">MREIVCIQAGQCGNQIGSKFWEVISDEHGVDPTGTYQGDSDLQLERINVYFDEATGGRYVPRSVLIDLEPGTMDSVRAGPYGQIFRPDNFIFGQSGAGNNWAKGHYTEGAELIDSVLDVCCKEAESCDCLQGFQICHSLGGGTGSGMGTLLISKLREQYPDRIMMTFSIIPSPKVSDTVVEPYNTTLSVHQLVENSDESMCIDNEALYDICFPLAQPATSTWCQGPVLFIGEEAKCQLRSRCYRVRSWFLAKGPEGCILKPSCRPPVRVVLSTTVSNVMSAHLRHPNRQCALQEALRQKLLLCGDVEANPGPLTVLQLNVQSLTKTKLSSLLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>F9W3Y6</accession>
    <name>F9W3Y6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 112</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_02990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
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                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
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        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <end position="114"/>
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            <end position="112"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CCD11864.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="636" mass="70473" checksum="7B4C3E04E4E79476" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
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            <taxon>Trypanosomatidae</taxon>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
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            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
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    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="CCD11912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="245" mass="27529" checksum="AC1A83EF0E6A2C5C" modified="2011-10-19" version="1">MKRSAKGADALNEAVTRGIRMAAKRTVQRGKGVAPPFWTPELTKLDKMVQECRNERKRDALIRWRTEVLVDTAMGRWKEHLSKLSTMDSASWNLVKSIYAPRPLTSPVLVVDGHSLTKRPQAQALAKMYMARSTKAPHAPEMRIPSTRRSTFRPITEAELDVALRELSSGTAPGDDEIYCEELKELRRVAKKCVLRLFDCSLFTGLLPSRWKLGIIVPLLKPNKPAGSMASFRPITLTSILCTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="20" xmlns="http://uniprot.org/uniprot">
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    <name>F9W4K3_TRYCI</name>
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        </submittedName>
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        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
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                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000567">
        <property type="protein sequence ID" value="CCD12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30120"/>
    <dbReference type="OMA" id="HWREIRF"/>
    <dbReference type="OrthoDB" id="358185at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1245"/>
            <end position="1278"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="16"/>
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            <begin position="332"/>
            <end position="372"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <begin position="523"/>
            <end position="537"/>
        </location>
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        <location>
            <begin position="1382"/>
            <end position="1403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1565" mass="173452" checksum="33DC1C404E7503E7" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4P2</accession>
    <name>F9W4P2_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WGS project CAEQ00000000 data, annotated contig 1208</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_30490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000584">
        <property type="protein sequence ID" value="CCD12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30490"/>
    <dbReference type="OMA" id="CAFSKRM"/>
    <dbReference type="OrthoDB" id="1449534at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="PTHR10293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="96"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20749" checksum="55939B62CB016FD1" modified="2011-10-19" version="1">MQRLCNSVVCRVTGVTYVPRHLSMAALCFPARSASITAALRDSAVITGTSNAGGDVRDTEETHPDFQPRLINADVAEDEVAMVKKDIDDTIKSEDVVTFIKGLPEAPMCAFSKRMIDVLDALGLEYTSFDVLAHPVVRTHVKEVSEWPTIPQLFIKGEFVGGLDIVTKMLESGDLKHLLQSKGITYRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>F9W4U7</accession>
    <name>F9W4U7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TCIL3000_0_30990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">IL3000</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000607">
        <property type="protein sequence ID" value="CCD12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_30990"/>
    <dbReference type="OrthoDB" id="1348670at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VSG_B" evidence="5">
        <location>
            <begin position="144"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CCD12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="276" mass="31710" checksum="B9A6AAB21CD691A6" modified="2011-10-19" version="1" fragment="single">MASSTESTDTETPPKAWTRPGTSVFFLLLFKNKIGKPYPFLCVEKVKSLWKMIITVFFLNTKEIKAMLIMKFSLVALVFCVDFGFTQPSAAEFNLFCRIWTEANDMMLEPDYVYDENVDKEIVKQMWVLFNATTDNMDDFRKTTWETKDFFQEHPPPTHSENRKRAHREIGHLIKEGEKQIEENRQLAKQVNDKIEAAKLSAAQGFYGEHVRRIPKNDRNLTEILNDTESIFNHHERSRESCGGKNKSTGKTLLNDFFCVCVGAGVDDSDGPCSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W531</accession>
    <name>F9W531_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000650">
        <property type="protein sequence ID" value="CCD12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="123" mass="14475" checksum="EF191C846A32543B" modified="2011-10-19" version="1">MYPNFFRAFTARYFIRFALLMSLADRLENSIPFTHRPLCCSSENPSGSVIQRPSSIQIKSKRLIMLHNPQGLFRHTPPFAFCGESCRNHDVSLSRHRDRGSITYHFQAHSNVRDFYFFMTRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W558</accession>
    <name>F9W558_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_31990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000662">
        <property type="protein sequence ID" value="CCD12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14973" checksum="C61384C001804006" modified="2011-10-19" version="1">MTRRRLLGTSTVVHKSWTLIRECFVAPRRRQSSWYNSSINSACSVVSTQAGMKQAQSVNESHGLKYWLLGFESVGKISLKAAQEHSKHCKTNWLFCYHRCCHKHNSNSSHKRFQNILIDTVMSERFKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5N5</accession>
    <name>F9W5N5_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1351</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_33630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000742">
        <property type="protein sequence ID" value="CCD12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33630"/>
    <dbReference type="OrthoDB" id="1731618at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="184" mass="18555" checksum="1BF29495BBAC76B7" modified="2011-10-19" version="1">MFHMENLAVGAFSTSTSGTCVSWRGSSLCVGAGSGGGDLVGMVSLTTTTSGWTSCPRGGAGGTARFLRLGMVPPKNSRSGGCCLLLSVVWVRTKTRRTGTSVLALGRAPHLGCLAGQGSAAFVQYHPLQLAIPSSPGPLASLYGARINPTSFGAVVSVAASTSGSHTSKYRPAGLPPECTARGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>F9W5P9</accession>
    <name>F9W5P9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WGS project CAEQ00000000 data, annotated contig 1356</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TCIL3000_0_33770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">IL3000</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000747">
        <property type="protein sequence ID" value="CCD12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_33770"/>
    <dbReference type="OMA" id="IVESRCD"/>
    <dbReference type="OrthoDB" id="1238370at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="517"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CCD12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="726" mass="79144" checksum="A1A1895C6142BF31" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2020-06-17" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W662</accession>
    <name>F9W662_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_35260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000826">
        <property type="protein sequence ID" value="CCD12666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14911" checksum="5123B8EFF457BE92" modified="2011-10-19" version="1">MNFPFLLWCFNLEYSWRCGVKIYFLRPLQYGRLVWLDGNFDCVTHVPYFLQFGIYGMLWGKHFISSLCILSLAHLHSSVTLNGSAVCRLNYWFQRSFQWSICGISSFFGCLPQYALHVCFLLQLLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6H6</accession>
    <name>F9W6H6_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP pyrophosphate-lyase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TCIL3000_0_36330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">IL3000</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could act as a receptor for an unknown ligand.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000873">
        <property type="protein sequence ID" value="CCD12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_36330"/>
    <dbReference type="OMA" id="NTIETMI"/>
    <dbReference type="OrthoDB" id="172467at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="8">
        <location>
            <begin position="699"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="923"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CCD12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114974" checksum="6EAD3CA994D1802E" modified="2011-10-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Q7</accession>
    <name>F9W6Q7_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1507</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_37050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000915">
        <property type="protein sequence ID" value="CCD12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37050"/>
    <dbReference type="OrthoDB" id="1708263at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="204" mass="21681" checksum="E3E386ED4D4337C1" modified="2011-10-19" version="1">MSGVEQASPIALRKSAVSSAPCESFVSDCGSERDTLRSAGNNSAVRDRSLPTFSVASQAIVFCQSPTIRHAREKSRRGRVAGEGRQFAGGSLRGSDDPFMDWLVSLSPKSSCSSINGSPRIVCVPESAVAGSPLHPSSEQSSVFMDAPLLESGSFCSQSSDGMSAMKQRHHLSAPPPLGDTRRQLREYPMLTLSPILRGEAKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6T2</accession>
    <name>F9W6T2_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="4">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_37270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="4"/>
    <dbReference type="EMBL" id="CAEQ01000933">
        <property type="protein sequence ID" value="CCD12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37270"/>
    <dbReference type="OMA" id="PCSRLPR"/>
    <dbReference type="OrthoDB" id="973532at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:NAD-dependent histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="348" mass="38112" checksum="31197FF8FE409F36" modified="2011-10-19" version="1">MGDSTQEIRHVVGEPTFEGLAQYIRKNNISKIVVMAGAGISVSAGIPDFRSPNVGLYAKLGKYNLHSPTDAFTLELLRQQPEVFYNILADMDLWPGRYCPTTVHHFISLLAKEGCLLCCFTQNIDGLERACGVPEDLLVEAHGSFSSASCVECRSKYDVSVAKAESRAGKVPRCSDCGGVVKPDVVFFGESLPKSFFHAVERIVEADLLLIMGTSLQVHPFAQLAISVRPGIPRVLFNYERVGGRMFRFPTDVLKVPHSQQANAGNNGHNRGDSGDEYDSSDSSDGYSQYVFENSGEQAVLRDIFFPGDCQVSVRSFAEALGLGEKLDEAVREGRKKFERGLGDMKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W6Z3</accession>
    <name>F9W6Z3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_37720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000952">
        <property type="protein sequence ID" value="CCD12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_37720"/>
    <dbReference type="OrthoDB" id="428855at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20144" checksum="6925AC754D7F8D7E" modified="2011-10-19" version="1">MSNSPSSPSPEGMVQDNTPWSMEKDVVEVLLKNLGDPEKINLYRFLQPAYPFMHSYVSRFSIRDFARNPWRCVGEADGREQVWQQFPRLLWQFRVLALKLTYYAGPPEGWGPREWEVWREFLKLDETDHDIMEGMVWAVCKMPSQPRGFLEAPYPIGHTGPIPMPHPPEPGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>F9W750</accession>
    <name>F9W750_TRYCI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TCIL3000_0_38310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">IL3000</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">IL3000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CAEQ01000985">
        <property type="protein sequence ID" value="CCD13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38310"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="662484at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="4">
        <location>
            <begin position="4"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CCD13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="376" mass="41303" checksum="C0632715E90450D1" modified="2011-10-19" version="1">MKVLVCGGAGYIGSHFVRALLRDTNHSVVIVDLLVGTHRHTGHVETLENALQKQRSSGGSQAGGERYAALEIGDVRDEKFLNDVFTRHTPIGAVVHMCAYLAVGESVRDPLKYYDNNVIGIVKILQTMKAHKCDKIIFSSSAAIFGNPAAGSSTCAMVPIDVDAKKMPESPYGESKLIAEWVIRDCAQAYGIKGVCLRYFNACGAHEDGDIGEHYRGSTHLIPIILGVALEGLKRGSGGAETGRHVPIFGTDYPTPDGTCIRDYVHVCDLASAHIHALDYVERLAPEERDKFFSVFNLGTSRGYSVREVIDVARKITGYNIPVVECPRREGDPAYLVAASDRAREVLGWRPRYDTLEAIIKTAWEFQRRHPDGHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W760</accession>
    <name>F9W760_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WGS project CAEQ00000000 data, annotated contig 1575</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_38410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000991">
        <property type="protein sequence ID" value="CCD13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38410"/>
    <dbReference type="OMA" id="YCWMASA"/>
    <dbReference type="OrthoDB" id="1109791at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389885" evidence="5">
        <location>
            <begin position="23"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Aa_trans" evidence="6">
        <location>
            <begin position="9"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="378" mass="40620" checksum="7E5252DAA6505D90" modified="2011-10-19" version="1">MAFIYPLIIVLVFVQSLYCIAAQVEKHSLKSYEGMARVLLGPRAAYAAGMLRVLNSFGACVAFVISVADILVAILQNSDAPDFLKSVTGNRLLTLGVWLCCMLPLVIPRQVDSLRYISTVGIIFCFYLMGVIVVHSCTNGLPENIKKIHLSGGPSDDGIHLFGTGNKAIEAPAVFTFAFLCQAASIEVYSSMAQPSVTRFTLYSAYAMAMCFVLNVTTAFFGYLDFGSKVTGSVLPMYDPVSQPAIMIGYIGLVVKLCTSYALSMFACRNGIYNVIGRDPDTTAFWEHCAVMVVLSTITLVCGLFIPNINTVFGFVGAVCGGFLAFIFPALFMMYGGGFTLQKVGPLCYTATYALLIFGVVLSVFGTVATIYGVATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>F9W781</accession>
    <name>F9W781_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1578</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_38620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01000994">
        <property type="protein sequence ID" value="CCD13046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38620"/>
    <dbReference type="OMA" id="WRDACED"/>
    <dbReference type="OrthoDB" id="1658129at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006518">
        <property type="entry name" value="Trypano_RHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07999">
        <property type="entry name" value="RHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01631">
        <property type="entry name" value="Trypano_RHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="533" mass="60292" checksum="FEE7E0DE0E9AD4C2" modified="2011-10-19" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-08-03" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7B9</accession>
    <name>F9W7B9_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 159</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_04110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">IL3000</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">IL3000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001008">
        <property type="protein sequence ID" value="CCD13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_04110"/>
    <dbReference type="OrthoDB" id="1668718at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031225">
        <property type="term" value="C:anchored component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042783">
        <property type="term" value="P:evasion of host immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001812">
        <property type="entry name" value="Trypano_VSG_A_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00913">
        <property type="entry name" value="Trypan_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003388758" evidence="8">
        <location>
            <begin position="25"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Trypan_glycop" evidence="9">
        <location>
            <begin position="30"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CCD13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="387" mass="42446" checksum="6824ADFFBA119FD2" modified="2011-10-19" version="1">MIMKTVSVWWIIAWGLMFRSEVSSASSRRKQAIPIEAGESICSLSKTLKDVPPWTQEKIADLRKTRDAYASKLLDWQLYFHGSSECGVNESIFGEIWVTLEAVDEEIKTLPTKAIRAGAFAAKSAGRLDEFITVFANAKKESFIDGVNYCLGGGGNPAKRRDLLDCFPEGEKLEIGEANIGKIPESMTNIKELNLTAALRNVNHSAVGSYFNRIHWIDLHAGCNLVKGASGGILGNVNLESPLWWGGGILTIGKNFDGNLSKVKDTKDIESDDNGATWTASPTTIPHLQKSLDAFQDFKDTAARITKKISEIEKIEKQIEPCLSNETTEEGPTQSCFKNAVRLNAELQAANALLARYHKEKGPLPSGSTLILNQSVVSAWCLIAFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7D4</accession>
    <name>F9W7D4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1591</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_38850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001009">
        <property type="protein sequence ID" value="CCD13100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_38850"/>
    <dbReference type="OrthoDB" id="1721296at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389899" evidence="1">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="173" mass="18970" checksum="F31052D7D957FF1B" modified="2011-10-19" version="1">MRSFVWVTLALWVAFSLSAELCGTVWKRGGGRGERLFTRWCALSASLCCACARRLLWHLGMNDTHLQQGVEGSGFAFAEVVLFYEGKTHAAGVAASAERGTCEVRAGELGWDVCVVVVAEHALALFGSRLAASCRSPRCGKCAHRASSSRAPTESLLILAFFQWLWRQHAYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7I4</accession>
    <name>F9W7I4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Variant surface glycoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TCIL3000_0_39290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">IL3000</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">IL3000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001039">
        <property type="protein sequence ID" value="CCD13150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39290"/>
    <dbReference type="OrthoDB" id="1676374at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025932">
        <property type="entry name" value="Trypano_VSG_B_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13206">
        <property type="entry name" value="VSG_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003389966" evidence="5">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="VSG_B" evidence="6">
        <location>
            <begin position="52"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CCD13150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="345" mass="38347" checksum="67358092ACA9611E" modified="2011-10-19" version="1">MMRMRVWMVMMVFFGVAASADEKNHNGEEHKALCKVLRAAVGKWGDGGKHLSGPLQKALAKTIFGEHSGGDTLDSLKRKLPDDYNGVVKELGSRFFVCGKPFLDDMRKKQPRVSGHSAPHDLLCLCTPGDRGWPLNNGEGKKLCGEDKSVWGGGKSGWASSRQGEGQMKETWTQVVAKCLNDGGKGENLKYALEIFIGSLGERKPGEHPYKSLGKGDFSSKYACSGKEQTGICVKYYPEDQKAIPWWNQLQDALNKEEQKEQNEREEAEKRKHEAQKQRQPQKQDHSQYPQGPRTAALRSATPSTEENEQSNTENISDSIATIEDTSRTLIVPSCPWLLSALLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>F9W7K3</accession>
    <name>F9W7K3_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WGS project CAEQ00000000 data, annotated contig 1622</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TCIL3000_0_39440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">IL3000</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001045">
        <property type="protein sequence ID" value="CCD13170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_39440"/>
    <dbReference type="OrthoDB" id="1729234at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CCD13170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19807" checksum="702D825B1425E1A8" modified="2011-10-19" version="1">MPFGCASLFKLIGRSLSGNEVSFPTFSSLFISFFTFFFVSWVLVSSSAVPSHPQLVCVGLSTVQHTAIIALVPIYIILCSILYFSLPLADLFYWLSLLPAFFSFGKEREAVYIHTLLYCKGIIGFDHILDVWLSCCILSGHAWTTLQQIIVDIKPFRTQRHCKILVSQHHCMCSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>F9W896</accession>
    <name>F9W896_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VSG-associated, congolense-specific ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001151">
        <property type="protein sequence ID" value="CCD13427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41770"/>
    <dbReference type="OrthoDB" id="1701528at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="199" mass="23251" checksum="3418E62851F1523B" modified="2011-10-19" version="1">MITHFPSPILAFSIRIPMSLYTITSPRTIPWSMERDVVEVLLEGVTSPDHVNLYWFLRPVLAGLPVDLVCFTLGDFVRNPRHCIPEVNVCDAIWQYLPYLLWKFRLSATPLVKHFGPTETWKKWHWDSWKIYYDMDDMPLEAIDEEIWRRCRRPPPVPQYQPYQGVVWVDPAPAFIQVPYSTVGYLVPIPLSPGDWPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2021-09-29" version="13" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8B4</accession>
    <name>F9W8B4_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WGS project CAEQ00000000 data, annotated contig 1724</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TCIL3000_0_41950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Donelson J.E."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Berriman M."/>
                <person name="Hertz-Fowler C."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">IL3000</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2012" name="Proc. Natl. Acad. Sci. U.S.A." volume="109" first="3416" last="3421">
            <title>Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Aslett M."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Vavrova-Anderson J."/>
                <person name="Brown R."/>
                <person name="Browne H."/>
                <person name="Corton N."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="Marcello L."/>
                <person name="McQuillan J."/>
                <person name="Otto T.D."/>
                <person name="Quail M.A."/>
                <person name="Sanders M.J."/>
                <person name="van Tonder A."/>
                <person name="Ginger M.L."/>
                <person name="Field M.C."/>
                <person name="Barry J.D."/>
                <person name="Hertz-Fowler C."/>
                <person name="Berriman M."/>
            </authorList>
            <dbReference type="PubMed" id="22331916"/>
            <dbReference type="DOI" id="10.1073/pnas.1117313109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">IL3000</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="CAEQ01001158">
        <property type="protein sequence ID" value="CCD13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="TriTrypDB:TcIL3000_0_41950"/>
    <dbReference type="OrthoDB" id="996120at2759"/>
    <dbReference type="Proteomes" id="UP000000702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CCD13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19429" checksum="BC5A9DBBED44F52D" modified="2011-10-19" version="1">MLPRETLNCMPVNLTRFYRKYGHLFRVLDGDNEPVIQRSDLPIPEQRSLSDIGSEEILVLLYNNFPRRRHPKFGTCMERCINGLPRCARLRLRELDLVNDVLRQHPDKVELCGEQDVDLTKVGVVESHPGWLQVFRFVGGYQEELIRRYEALCLKHGQDPNTTTKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-10-19" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>F9W8S6</accession>
    <name>F9W8S6_TRYCI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WGS project CAEQ00000000 data, annotated contig 177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TCIL3000_0_04540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Trypanosoma congolense (strain IL3000)</name>
        <dbReference type="NCBI Taxonomy" id="1068625"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Discoba</taxon>
            <taxon>Euglenozoa</taxon>
            <taxon>Kinetoplastea</taxon>
            <taxon>Metakinetoplastina</taxon>
            <taxon>Trypanosomatida</taxon>
            <taxon>Trypanosomatidae</taxon>
            <taxon>Trypanosoma</taxon>
            <taxon>Nannomonas</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2011-07" db="EMBL/GenBank/DDBJ databases">
            <title>Divergent evolution of antigenic variation in African trypanosomes.</title>
            <authorList>
                <person name="Jackson A.P."/>
                <person name="Berry A."/>
                <person name="Allison H.C."/>
                <person name="Burton P."/>
                <person name="Anderson J."/>
                <person name="Aslett M."/>
                <person name="Brown R."/>
                <person name="Corton N."/>
                <person name="Harris D."/>
                <person name="Hauser H."/>
                <person name="Gamble J."/>
                <person name="Gilderthorp R."/>
                <person name="McQuillan J."/>
                <person name="Quail M.A."/>
                <person name="Sanders M."/>
                <person name="Van Tonder A."/>
                <person name="Ginger M.L."/>
                <pers